MCID: IMP005
MIFTS: 52

Impotence malady

Summaries for Impotence

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Erectile dysfunction (ed) is a common type of male sexual dysfunction. it is when a man has trouble getting or keeping an erection. ed becomes more common as you get older. but it's not a natural part of aging. some people have trouble speaking with their doctors about sex. but if you have ed, you should tell your doctor. ed can be a sign of health problems. it may mean your blood vessels are clogged. it may mean you have nerve damage from diabetes. if you don't see your doctor, these problems will go untreated. your doctor can offer several new treatments for ed. for many men, the answer is as simple as taking a pill. getting more exercise, losing weight, or stopping smoking may also help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Impotence, also known as erectile dysfunction, is related to prostatitis and ischemic heart disease. An important gene associated with Impotence is VIP (vasoactive intestinal peptide), and among its related pathways is NO-dependent CFTR activation (normal and CF). The drugs methyltestosterone and papaverine and the compounds tamsulosin and ment have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and prostate.

Wikipedia:63 Erectile dysfunction (ED) or impotence is sexual dysfunction characterized by the inability to develop... more...

Aliases & Classifications for Impotence

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

impotence 8 10 44
erectile dysfunction 8 44 33 60
sexual impotence 8


External Ids:

Disease Ontology8 DOID:1875

Related Diseases for Impotence

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impotence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.6SRD5A1, PDE5A, KLK3
2ischemic heart disease30.5ENTPD1, KNG1, PDE5A
3atherosclerosis30.5PDE5A, KNG1, SHBG, NOS1, ELN
4obesity30.4SRD5A1, NOS1, SHBG, KNG1, PDE5A
5prostate cancer30.4KLK3, SRD5A1
6infertility30.3SHBG, PRL, GNRH1
7diabetes mellitus30.3SHBG, KNG1, PDE5A
8acute myocardial infarction30.0NOS1
9arteriosclerosis30.0ELN
10hypothyroidism30.0SHBG, PRL, GNRH1
11essential hypertension30.0KNG1, SHBG, ADRA1D
12myocardial infarction30.0PDE5A, KNG1, SHBG, NOS1
13rhinitis30.0VIP, PDE5A, KNG1
14adenoma30.0GNRH1, PRL, SHBG, NOS1, SRD5A1
15premature ejaculation30.0PDE5A
16vascular disease30.0ELN, NOS1
17varicocele30.0SHBG, PRL, GNRH1
18penile disease30.0PRL, GNRH1, KLK3
19oligospermia30.0GNRH1, PRL, SRD5A1
20hypertension30.0PDE5A, KNG1, ADRA1D
21gynecomastia30.0KLK3, GNRH1, PRL, SHBG, SRD5A1
22hypogonadism30.0KLK3, GNRH1, PDE5A, PRL, SHBG
23asthma30.0VIP, KCNMA1, KNG1, NOS1
24alopecia29.8SHBG
25arthritis29.8KNG1, VIP
26prolactinoma29.8PRL, GNRH1
27multiple sclerosis29.8BLVRB
28leydig cell tumor29.8GNRH1, SRD5A1
29cryptorchidism29.8GNRH1, SHBG, SRD5A1
30azoospermia29.7GNRH1, PRL, SHBG, SRD5A1
31hyperprolactinemia29.7VIP, GNRH1, PRL, SHBG, SRD5A1
32vasculogenic impotence10.8
33ischemic neuropathy10.5
34ischemic optic neuropathy10.5
35coronary artery disease10.3
36type 2 diabetes mellitus10.3
37urethritis10.3
38peyronie's disease10.3
39peripheral vascular disease10.3
40generalized atherosclerosis10.3
41periodontitis10.3
42klippel-trenaunay syndrome10.2
43sensorineural hearing loss10.2
44tabes dorsalis10.2
45restless legs syndrome10.2
46hyperhomocysteinemia10.2
47hepatitis a10.2
48autonomic neuropathy10.2
49glaucoma10.2
50hepatitis10.2

Graphical network of the top 20 diseases related to Impotence:



Diseases related to impotence

Clinical Features for Impotence

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Drugs & Therapeutics for Impotence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Impotence

Drug clinical trials:

Search ClinicalTrials for Impotence

Search NIH Clinical Center for Impotence

Search CenterWatch for Impotence

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Impotence

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Anatomical Context for Impotence

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Sources:
32MalaCards
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MalaCards organs/tissues related to Impotence:

32
Kidney, Brain, Prostate, Testes, Endothelial, Spinal cord, Heart, Smooth muscle, Skin, Eye, Temporal lobe

Animal Models for Impotence or affiliated genes

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Publications for Impotence

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Sources:
50PubMed
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Articles related to Impotence:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Endovascular embolisation therapy in men with erectile impotence due to veno-occlusive dysfunction. (23219214)
2013
2
The impotence of price controls: failed attempts to constrain pharmaceutical expenditures in Greece. (20884073)
2011
3
Nocturnal erections, differential diagnosis of impotence, and diabetes. I Karacan, FB Scott, PJ Salis, SL Attia, JC Ware, A Altinel, and RL Williams. (19215613)
2009
4
Abstracts of the VIII Congress of the Latin American Society for Sexual and Impotence Research (SLAIS) December 1-3, 2005. (16497241)
2006
5
HMG CoA reductase inhibitors and impotence: two case series from the Spanish and French drug monitoring systems. (16454541)
2006
6
Recent data upon impotence, incontinence and quality of life issues concerning radical prostatectomy. (12768997)
2003
7
Abstracts of the VII Latin American Congress for the Study of Impotence and Sexuality. Cortagena de Indias, Colombia, 20-23 August 2003. (12923558)
2003
8
The place of surgery for vascular impotence in the third millennium. (14501742)
2003
9
Urethral wands for impotence. (11251540)
2001
10
Penile implants in the treatment of organic impotence. (11255607)
2001
11
Penile implants in the treatment of organic impotence. (24185226)
2001
12
Focus on sexual dysfunction, tissue engineering, gene therapy: highlights from the first fall meeting of the society for the study of impotence october 1-3, 1999, Boston. (16985764)
2000
13
Low plasma testosterone in varicocele patients with impotence and male infertility. (11111867)
2000
14
European Society for Impotence Research--third meeting. 30 January-2 February 2000, Barcelona, Spain. (16100696)
2000
15
The role of adrenomedullin in varicocele and impotence. (11069379)
2000
16
Is it okay for men with macular degeneration to take the anti-impotence drug Viagra? Can it accelerate blindness by rupturing blood vessels in the eye? (11070789)
2000
17
Sildenafil: an oral drug for impotence. (9599594)
1998
18
Gadolinium-enhanced magnetic resonance angiography of the pelvis in patients with erectile impotence. (9351029)
1997
19
Angiography/interventional case of the day. Arteriogenic impotence from posttraumatic bilateral proximal cavernosal artery occlusions. (9207540)
1997
20
Impotence and nerve entrapment in long distance amateur cyclists. (9150814)
1997
21
Impotence. (8558657)
1996
22
Vacuum erection associated impotence and Peyronie's disease. (8558654)
1996
23
Patient satisfaction with current impotence therapy. (8560907)
1995
24
The rationale for prostaglandin E1 (alpha-alprostadil) in the management of male impotence. (7732903)
1995
25
Double-blind randomized crossover study comparing intracorporeal prostaglandin E1 with combination of prostaglandin E1 and lidocaine in the treatment of organic impotence. (7771004)
1995
26
The effect of age, ethnicity and geographical location on impotence and quality of life. (7613802)
1995
27
Impotence. (7714972)
1995
28
Overview of current operations for impotence. (8579328)
1995
29
Impotence: diagnosis and management of male erectile dysfunction. (8173405)
1994
30
Comparison of duplex ultrasonography and nocturnal penile tumescence in evaluation of impotence. (8189562)
1994
31
Construction of a surrogate variable for impotence in the Massachusetts Male Aging Study. (7730871)
1994
32
Psychogenic impotence. (7704746)
1994
33
Vacuum tumescence constriction therapy for neuropathic impotence. (22912201)
1994
34
Nitric oxide synthase: a new diagnostic tool for neurogenic impotence. (7692661)
1993
35
Endocrine causes of impotence. (7507006)
1993
36
Venous impotence: pathophysiology, diagnosis and treatment. (8479008)
1993
37
Analysis of microsurgical penile revascularization results by etiology of impotence. (8479022)
1993
38
Managing impotence in diabetes. Wait to be asked before offering advice. (8401116)
1993
39
Impotence: the internist's approach to diagnosis and treatment. (8438635)
1993
40
Intracavernous sodium nitroprusside: inappropriate impotence treatment. (8345601)
1993
41
Intracavernous papaverine for impotence in spinal cord injured patients. (8259331)
1993
42
The importance of hyperprolactinemia in impotence. (8052792)
1993
43
A new vacuum device as alternative treatment for impotence. (1486393)
1992
44
Aorto-iliac/femoral reconstructions in patients with vasculogenic impotence. (1915908)
1991
45
Diagnosis of vasculogenic impotence. Comparing investigations by Doppler sonography and angiography. (3041769)
1988
46
Yohimbine plus intracavernous vasodilators in mild vasculogenic impotence. (3400531)
1988
47
Early experience with balloon angioplasty of internal iliac arteries for vasculogenic impotence. (2953430)
1987
48
The noninvasive diagnosis of vasculogenic impotence. (3951033)
1986
49
Vasculogenic impotence. (7268634)
1981
50
Idiopathic chronic orthostatic hypotension associated with anhidrosis, impotence and changing pulse (cardiac arrhythmia). A case report and review of subject. (4655519)
1972

Genetic Variations for Impotence

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Expression for genes affiliated with Impotence

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impotence

Search GEO for disease gene expression data for Impotence.

Pathways for genes affiliated with Impotence

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Pathways related to Impotence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NO-dependent CFTR activation (normal and CF)
9.9NOS1, PDE5A

Compounds for genes affiliated with Impotence

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Impotence according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1tamsulosin28 44 1112.3KLK3, ADRA1D
2ment4410.1SHBG, SRD5A1, KLK3
3leuprolide acetate4410.0KLK3, GNRH1, PRL, SHBG
4androstenediol4410.0KLK3, SHBG, SRD5A1
5leuprolide44 59 28 1112.9KLK3, GNRH1, PRL, SRD5A1
6goserelin44 28 1111.9SRD5A1, SHBG, GNRH1, KLK3
7methoxamine28 44 1111.8VIP, ADRA1D, KNG1
817-hydroxyprogesterone44 2410.8SRD5A1, SHBG, PRL, GNRH1
9alfuzosin44 1110.8ADRA1D, SRD5A1, KLK3
10ng-nitro-l-arginine449.8VIP, KNG1, BLVRB, NOS1
11spironolactone49 44 59 28 1113.8KLK3, GNRH1, SHBG, SRD5A1
12tetraethylammonium44 28 1111.8NOS1, KCNMA1, VIP, KNG1
13acetylcholine44 49 28 11 2413.8KCNMA1, KNG1, BLVRB, NOS1
14citrulline44 2410.7KNG1, VIP, BLVRB, NOS1
15dhea449.7KLK3, KCNMA1, PRL, SRD5A1, SHBG
16estrogen449.7KLK3, PDE5A, SRD5A1, ELN
17cyproteroneacetate449.7KLK3, GNRH1, PRL, SRD5A1, SHBG
18flutamide44 59 1111.7GNRH1, SHBG, KLK3, SRD5A1, PRL
19terazosin44 1110.7KLK3, SRD5A1, ADRA1D
20dehydroepiandrosterone sulfate449.7KLK3, GNRH1, PRL, SHBG, SRD5A1
21sildenafil44 49 28 11 2413.6SRD5A1, SHBG, PDE5A, VIP, NOS1
22bromocriptine28 44 1111.6VIP, GNRH1, ADRA1D, PRL, SHBG
23phentolamine28 44 1111.6ADRA1D, PDE5A, GNRH1, VIP
24thyroxine44 2410.5GNRH1, KLK3, PRL, SHBG, VIP
255-hydroxytryptamine449.5GNRH1, VIP, KNG1, PRL, NOS1
26phenylephrine44 28 11 2412.5ADRA1D, KNG1, NOS1, KCNMA1, VIP
27guanylate449.5KCNMA1, NOS1, KNG1, PDE5A, VIP
28l-nmma449.5KNG1, NOS1, KCNMA1, VIP
29dihydrotestosterone44 28 11 2412.5KLK3, VIP, GNRH1, SHBG, PRL, SRD5A1
30nifedipine44 49 28 1112.5ELN, VIP, KCNMA1, GNRH1, KNG1
31nitroglycerin44 1110.5BLVRB, NOS1, VIP, KNG1, PDE5A
32progestins449.4SHBG, GNRH1, SRD5A1, KLK3
33isoproterenol44 1110.3GNRH1, PDE5A, NOS1, KNG1, VIP, KCNMA1
34methacholine44 1110.3VIP, KNG1, NOS1, KCNMA1
35gnrh449.3SRD5A1, GNRH1, VIP, KLK3, SHBG, BLVRB
36epinephrine44 11 2411.3PRL, GNRH1, ADRA1D, SHBG, KLK3, VIP
37norepinephrine44 11 2411.2ADRA1D, ENTPD1, PRL, VIP, GNRH1, PDE5A
38prostacyclin449.2VIP, KCNMA1, KNG1, ENTPD1, PDE5A
39gaba449.2NOS1, VIP, KCNMA1, GNRH1, BLVRB, SRD5A1
40formaldehyde44 2410.2ELN, NOS1, BLVRB, KLK3, GNRH1
41histamine44 28 2411.1PDE5A, ELN, VIP, KCNMA1, NOS1, KNG1
42cgmp44 2810.0VIP, NOS1, KCNMA1, PDE5A, BLVRB, KNG1
43estradiol44 11 2411.0KCNMA1, KLK3, GNRH1, PRL, SHBG, BLVRB
44dexamethasone44 49 28 1111.9VIP, GNRH1, PRL, SRD5A1, SHBG, NOS1
45dopamine44 28 11 2411.9SHBG, BLVRB, NOS1, SRD5A1, PDE5A, GNRH1
46adenylate448.9VIP, KCNMA1, GNRH1, KNG1, SHBG, BLVRB
47indomethacin44 59 28 1111.8PDE5A, KNG1, BLVRB, NOS1, SRD5A1, ELN
48sodium nitroprusside448.7KCNMA1, GNRH1, PDE5A, KNG1, ELN, BLVRB
49arginine448.3ELN, SHBG, KCNMA1, PRL, KNG1, VIP
50testosterone44 59 11 2411.3ELN, GNRH1, SRD5A1, NOS1, KLK3, VIP

GO Terms for genes affiliated with Impotence

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Sources:
16Gene Ontology
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Cellular components related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.9ELN, SHBG, PRL, KNG1, GNRH1, VIP

Biological processes related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of potassium ion transportGO:04326710.1NOS1, VIP
2multicellular organismal response to stressGO:03355510.1NOS1, PRL
3N-terminal protein myristoylationGO:0064999.7NMT2, NMT1
4ovulation cycleGO:0426989.7PRL, GNRH1
5protein lipoylationGO:0092499.7NMT2, NMT1
6blood coagulationGO:0075969.1KCNMA1, PDE5A, KNG1, NOS1, ENTPD1

Molecular functions related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8PRL, GNRH1, VIP
2glycylpeptide N-tetradecanoyltransferase activityGO:0043799.3NMT2, NMT1

Products for genes affiliated with Impotence

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Impotence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet