MCID: IMP005
MIFTS: 47

Impotence malady

Summaries for Impotence

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

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MedlinePlus:34 Erectile dysfunction (ed) is a common type of male sexual dysfunction. it is when a man has trouble getting or keeping an erection. ed becomes more common as you get older. but it's not a natural part of aging. some people have trouble speaking with their doctors about sex. but if you have ed, you should tell your doctor. ed can be a sign of health problems. it may mean your blood vessels are clogged. it may mean you have nerve damage from diabetes. if you don't see your doctor, these problems will go untreated. your doctor can offer several new treatments for ed. for many men, the answer is as simple as taking a pill. getting more exercise, losing weight, or stopping smoking may also help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Impotence, also known as erectile dysfunction, is related to atherosclerosis and infertility. An important gene associated with Impotence is VIP (vasoactive intestinal peptide), and among its related pathways is NO-dependent CFTR activation (normal and CF). The drugs papaverine and papaverine hydrochloride and the compounds tamsulosin and ment have been mentioned in the context of this disorder.

Wikipedia:64 Erectile dysfunction (ED) or impotence is sexual dysfunction characterized by the inability to develop... more...

Aliases & Classifications for Impotence

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS
See all sources

Aliases & Descriptions:

impotence 8 10 45
erectile dysfunction 8 45 34 61
sexual impotence 8


External Ids:

Disease Ontology8 DOID:1875

Related Diseases for Impotence

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Impotence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.5PDE5A, SHBG, KNG1, NOS1, ELN
2infertility30.3PRL, SHBG, GNRH1
3varicocele30.2GNRH1, PRL, SHBG
4insulin resistance30.1SHBG
5acute myocardial infarction30.1NOS1
6coronary heart disease30.0PDE5A, SHBG
7premature ejaculation30.0PDE5A
8arteriosclerosis30.0ELN
9vascular disease30.0NOS1, ELN
10oligospermia30.0GNRH1, SRD5A1, PRL
11adenoma30.0SRD5A1, SHBG, PRL, GNRH1, NOS1
12gynecomastia30.0KLK3, GNRH1, PRL, SHBG, SRD5A1
13asthma30.0NOS1, KCNMA1, VIP, KNG1
14alopecia29.8SHBG
15arthritis29.8KNG1, VIP
16prolactinoma29.8GNRH1, PRL
17azoospermia29.8PRL, GNRH1, SRD5A1, SHBG
18hyperprolactinemia29.8PRL, SHBG, VIP, GNRH1, SRD5A1
19pulmonary disease, chronic obstructive29.8PDE5A, SHBG, ELN
20vasculogenic impotence10.9
21ischemic neuropathy10.5
22ischemic optic neuropathy10.5
23optic neuropathy, anterior ischemic10.5
24chronic pain10.4
25coronary artery disease,10.4
26nonarteritic anterior ischemic optic neuropathy10.4
27peripheral vascular disease10.3
28generalized atherosclerosis10.3
29klippel-trenaunay syndrome10.2
30hepatitis c10.2
31sensorineural hearing loss10.2
32tabes dorsalis10.2
33hepatitis e10.2
34restless legs syndrome10.2
35hyperhomocysteinemia10.2
36hepatitis d10.2
37n syndrome10.2
38autonomic neuropathy10.2
39testicular cancer10.2
40viral hepatitis10.2
41central serous chorioretinopathy10.2
42cardiovascular disease risk factor10.2
43peyronie's disease10.1
44stroke, ischemic10.1
45axonal neuropathy10.1
46antiphospholipid syndrome10.1
47avoidant personality disorder10.1
48major depressive disorder10.1
49conversion disorder10.1
50polycythemia vera10.1

Graphical network of the top 20 diseases related to Impotence:



Diseases related to impotence

Clinical Features for Impotence

Drugs & Therapeutics for Impotence

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Impotence

Drug clinical trials:

Search ClinicalTrials for Impotence

Search NIH Clinical Center for Impotence

Search CenterWatch for Impotence

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Impotence

Anatomical Context for Impotence

Animal Models for Impotence or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Impotence

Sources:
51PubMed
See all sources

Articles related to Impotence:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Impotence in the 18th and 19th century: concepts of etiology and approaches to therapy. (20013735)
2009
2
Impotence and libido in Arabic medical literature. (18792558)
2008
3
Transient impotence after transrectal ultrasound-guided prostate biopsy. (17924579)
2008
4
Vasculogenic impotence as a symptom in late-onset Buerger's disease. (17486572)
2007
5
Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A(2B) receptor dysfunction. (16837560)
2006
6
Clinical observation on the therapeutic effects of heavy moxibustion plus point-injection in treatment of impotence. (15270266)
2004
7
The association of ED (erectile dysfunction) with ED (endothelial dysfunction) in the International Journal of Impotence Research: The Journal of Sexual Medicine. (12934048)
2003
8
Experience with 'capsule sparing' cystoprostadenectomy for orthotopic bladder replacement: overcoming the problems of impotence, incontinence and difficult urethral anastomosis. (12230627)
2002
9
Impotence and genital numbness in cyclists. (11531032)
2001
10
Looking beyond Viagra. The 30 million American men with impotence problems may soon have two oral treatments to choose from. How do they compare? (10848380)
2000
11
Advances in the diagnosis and management of impotence. (9987493)
1999
12
Current treatment of impotence: Viagra and other options. (10347410)
1999
13
The role of Viagra in the treatment of male impotence in ESRD. (10418355)
1999
14
The causes of patient dropout from penile self-injection therapy for impotence. (10492182)
1999
15
The 8th World Meeting on Impotence Research. Amsterdam, The Netherlands, 25-28 August 1998. Abstracts. (9827178)
1998
16
Advances in the management of impotence. (9503755)
1998
17
Alprostadil for impotence. (9504550)
1998
18
Take care when prescribing new drug to treat impotence, MDs warned. (9676555)
1998
19
Sildenafil (Viagra): the new pill for impotence. (9644499)
1998
20
Is diabetic neuropathy responsible for diabetic impotence? (9188140)
1997
21
Anxiety-induced failure in erectile response to intracorporeal prostaglandin-E1 in non-organic male impotence: a new diagnostic approach. (9292324)
1997
22
Drugs for the treatment of impotence. (9259177)
1997
23
Radiologic evaluation of penile arterial anatomy in arteriogenic impotence. (9205876)
1997
24
Can NPTR data predict the cause of organic impotence? (9287436)
1997
25
Practice trends of American urologists in the treatment of impotence, incontinence and infertility. (8863607)
1996
26
Vasoactive intestinal peptide and impotence in experimental diabetes mellitus. (8800898)
1996
27
Ultrasound evaluation of the penis for assessment of impotence. (8884525)
1996
28
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
29
ACE inhibitors and impotence: a case series from the Spanish drug monitoring system. (7576264)
1995
30
Impotence: expanding the horizons. (7869482)
1995
31
Alprostadil for erectile impotence. (8529540)
1995
32
Experience with buccal phentolamine mesylate for impotence. (7517275)
1994
33
Stearyl-norleucine-vasoactive intestinal peptide (VIP): a novel VIP analog for noninvasive impotence treatment. (8156912)
1994
34
Psychogenic versus primary organic impotence. (7951703)
1994
35
Multidisciplinary evaluation of diabetic impotence. (7713129)
1994
36
Diagnosis and treatment of vasculogenic impotence. (7618374)
1994
37
Consensus development conference statement. National Institutes of Health. Impotence. December 7-9, 1992. (8173631)
1993
38
Special issue: impotence and infertility. (8479007)
1993
39
Intracavernous pharmacotherapy for impotence: selection of appropriate agent and dose. (8479018)
1993
40
Impotence associated with cinnarizine. (8453180)
1993
41
Posttraumatic impotence: magnetic resonance imaging and duplex ultrasound in diagnosis and management. (8479013)
1993
42
Re: Diagnostic value of the radioisotope erection penogram for vasculogenic impotence. (1729525)
1992
43
A fatty neuropeptide. Potential drug for noninvasive impotence treatment in a rat model. (1522236)
1992
44
Re: Venogenic impotence following dermal graft repair for Peyronie's disease. (1404653)
1992
45
Algorithm for the delineation and treatment of vasculogenic impotence. A review. (2651349)
1989
46
The noninvasive diagnosis of vasculogenic impotence. (3373624)
1988
47
Transluminal angioplasty for treatment of vasculogenic impotence. (6211967)
1982
48
Radioisotope penogram in diagnosis of vasculogenic impotence. (6293142)
1982
49
Plasma testosterone and testosterone binding affinities in men with impotence, oligospermia, azoospermia, and hypogonadism. (4819173)
1974
50
Orthostatic hypotension, anhidrosis, and impotence. (14936198)
1952

Genetic Variations for Impotence

Expression for genes affiliated with Impotence

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Impotence

Search GEO for disease gene expression data for Impotence.

Pathways for genes affiliated with Impotence

Pathways related to Impotence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NO-dependent CFTR activation (normal and CF)
9.9NOS1, PDE5A

Compounds for genes affiliated with Impotence

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB
See all sources

Compounds related to Impotence according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1tamsulosin29 45 1112.3KLK3, ADRA1D
2ment4510.1SHBG, SRD5A1, KLK3
3leuprolide acetate4510.0KLK3, GNRH1, PRL, SHBG
4androstenediol4510.0KLK3, SHBG, SRD5A1
5leuprolide45 60 29 1112.9KLK3, GNRH1, PRL, SRD5A1
6goserelin45 29 1111.9SRD5A1, SHBG, GNRH1, KLK3
7methoxamine29 45 1111.8VIP, ADRA1D, KNG1
817-hydroxyprogesterone45 2410.8SRD5A1, SHBG, PRL, GNRH1
9alfuzosin45 1110.8ADRA1D, SRD5A1, KLK3
10ng-nitro-l-arginine459.8VIP, KNG1, BLVRB, NOS1
11spironolactone50 45 60 29 1113.8KLK3, GNRH1, SHBG, SRD5A1
12tetraethylammonium45 29 1111.8NOS1, KCNMA1, VIP, KNG1
13acetylcholine45 50 29 11 2413.8KCNMA1, KNG1, BLVRB, NOS1
14citrulline45 2410.7KNG1, VIP, BLVRB, NOS1
15dhea459.7KLK3, KCNMA1, PRL, SRD5A1, SHBG
16estrogen459.7KLK3, PDE5A, SRD5A1, ELN
17cyproteroneacetate459.7KLK3, GNRH1, PRL, SRD5A1, SHBG
18flutamide45 60 1111.7GNRH1, SHBG, KLK3, SRD5A1, PRL
19terazosin45 1110.7KLK3, SRD5A1, ADRA1D
20dehydroepiandrosterone sulfate459.7KLK3, GNRH1, PRL, SHBG, SRD5A1
21sildenafil45 50 29 11 2413.6SRD5A1, SHBG, PDE5A, VIP, NOS1
22bromocriptine29 45 1111.6VIP, GNRH1, ADRA1D, PRL, SHBG
23phentolamine29 45 1111.6ADRA1D, PDE5A, GNRH1, VIP
24thyroxine45 2410.5GNRH1, KLK3, PRL, SHBG, VIP
255-hydroxytryptamine459.5GNRH1, VIP, KNG1, PRL, NOS1
26phenylephrine45 29 11 2412.5ADRA1D, KNG1, NOS1, KCNMA1, VIP
27guanylate459.5KCNMA1, NOS1, KNG1, PDE5A, VIP
28l-nmma459.5KNG1, NOS1, KCNMA1, VIP
29dihydrotestosterone45 29 11 2412.5KLK3, VIP, GNRH1, SHBG, PRL, SRD5A1
30nifedipine45 50 29 1112.5ELN, VIP, KCNMA1, GNRH1, KNG1
31nitroglycerin45 1110.5BLVRB, NOS1, VIP, KNG1, PDE5A
32progestins459.4SHBG, GNRH1, SRD5A1, KLK3
33isoproterenol45 1110.3GNRH1, PDE5A, NOS1, KNG1, VIP, KCNMA1
34methacholine45 1110.3VIP, KNG1, NOS1, KCNMA1
35gnrh459.3SRD5A1, GNRH1, VIP, KLK3, SHBG, BLVRB
36epinephrine45 11 2411.3PRL, GNRH1, ADRA1D, SHBG, KLK3, VIP
37norepinephrine45 11 2411.2ADRA1D, ENTPD1, PRL, VIP, GNRH1, PDE5A
38prostacyclin459.2VIP, KCNMA1, KNG1, ENTPD1, PDE5A
39gaba459.2NOS1, VIP, KCNMA1, GNRH1, BLVRB, SRD5A1
40formaldehyde45 2410.2ELN, NOS1, BLVRB, KLK3, GNRH1
41histamine45 29 2411.1PDE5A, ELN, VIP, KCNMA1, NOS1, KNG1
42cgmp45 2910.0VIP, NOS1, KCNMA1, PDE5A, BLVRB, KNG1
43estradiol45 11 2411.0KCNMA1, KLK3, GNRH1, PRL, SHBG, BLVRB
44dexamethasone45 50 29 1111.9VIP, GNRH1, PRL, SRD5A1, SHBG, NOS1
45dopamine45 29 11 2411.9SHBG, BLVRB, NOS1, SRD5A1, PDE5A, GNRH1
46adenylate458.9VIP, KCNMA1, GNRH1, KNG1, SHBG, BLVRB
47indomethacin45 60 29 1111.8PDE5A, KNG1, BLVRB, NOS1, SRD5A1, ELN
48sodium nitroprusside458.7KCNMA1, GNRH1, PDE5A, KNG1, ELN, BLVRB
49arginine458.3ELN, SHBG, KCNMA1, PRL, KNG1, VIP
50testosterone45 60 11 2411.3ELN, GNRH1, SRD5A1, NOS1, KLK3, VIP

GO Terms for genes affiliated with Impotence

Sources:
16Gene Ontology
See all sources

Cellular components related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.9ELN, SHBG, PRL, KNG1, GNRH1, VIP

Biological processes related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of potassium ion transportGO:04326710.1NOS1, VIP
2multicellular organismal response to stressGO:03355510.1NOS1, PRL
3N-terminal protein myristoylationGO:0064999.7NMT2, NMT1
4ovulation cycleGO:0426989.7PRL, GNRH1
5protein lipoylationGO:0092499.7NMT2, NMT1
6blood coagulationGO:0075969.1KCNMA1, PDE5A, KNG1, NOS1, ENTPD1

Molecular functions related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8PRL, GNRH1, VIP
2glycylpeptide N-tetradecanoyltransferase activityGO:0043799.3NMT2, NMT1

Products for genes affiliated with Impotence

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Impotence

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet