MCID: IMP005
MIFTS: 52

Impotence malady

Summaries for Impotence

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Erectile dysfunction (ed) is a common type of male sexual dysfunction. it is when a man has trouble getting or keeping an erection. ed becomes more common as you get older. but it's not a natural part of aging. some people have trouble speaking with their doctors about sex. but if you have ed, you should tell your doctor. ed can be a sign of health problems. it may mean your blood vessels are clogged. it may mean you have nerve damage from diabetes. if you don't see your doctor, these problems will go untreated. your doctor can offer several new treatments for ed. for many men, the answer is as simple as taking a pill. getting more exercise, losing weight, or stopping smoking may also help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Impotence, also known as erectile dysfunction, is related to prostatitis and ischemic heart disease. An important gene associated with Impotence is VIP (vasoactive intestinal peptide), and among its related pathways is NO-dependent CFTR activation (normal and CF). The drugs papaverine and papaverine hydrochloride and the compounds tamsulosin and ment have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and prostate.

Wikipedia:63 Erectile dysfunction (ED) or impotence is sexual dysfunction characterized by the inability to develop... more...

Aliases & Classifications for Impotence

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

impotence 8 10 44
erectile dysfunction 8 44 33 60
sexual impotence 8


External Ids:

Disease Ontology8 DOID:1875

Related Diseases for Impotence

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impotence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.6SRD5A1, PDE5A, KLK3
2ischemic heart disease30.5ENTPD1, KNG1, PDE5A
3atherosclerosis30.5PDE5A, KNG1, SHBG, NOS1, ELN
4obesity30.4SRD5A1, NOS1, SHBG, KNG1, PDE5A
5prostate cancer30.4KLK3, SRD5A1
6infertility30.3SHBG, PRL, GNRH1
7diabetes mellitus30.3SHBG, KNG1, PDE5A
8acute myocardial infarction30.0NOS1
9arteriosclerosis30.0ELN
10hypothyroidism30.0SHBG, PRL, GNRH1
11essential hypertension30.0KNG1, SHBG, ADRA1D
12myocardial infarction30.0PDE5A, KNG1, SHBG, NOS1
13rhinitis30.0VIP, PDE5A, KNG1
14adenoma30.0GNRH1, PRL, SHBG, NOS1, SRD5A1
15premature ejaculation30.0PDE5A
16vascular disease30.0ELN, NOS1
17varicocele30.0SHBG, PRL, GNRH1
18penile disease30.0PRL, GNRH1, KLK3
19oligospermia30.0GNRH1, PRL, SRD5A1
20hypertension30.0PDE5A, KNG1, ADRA1D
21gynecomastia30.0KLK3, GNRH1, PRL, SHBG, SRD5A1
22hypogonadism30.0KLK3, GNRH1, PDE5A, PRL, SHBG
23asthma30.0VIP, KCNMA1, KNG1, NOS1
24alopecia29.8SHBG
25arthritis29.8KNG1, VIP
26prolactinoma29.8PRL, GNRH1
27multiple sclerosis29.8BLVRB
28leydig cell tumor29.8GNRH1, SRD5A1
29cryptorchidism29.8GNRH1, SHBG, SRD5A1
30azoospermia29.7GNRH1, PRL, SHBG, SRD5A1
31hyperprolactinemia29.7VIP, GNRH1, PRL, SHBG, SRD5A1
32vasculogenic impotence10.8
33ischemic neuropathy10.5
34ischemic optic neuropathy10.5
35coronary artery disease10.3
36type 2 diabetes mellitus10.3
37urethritis10.3
38peyronie's disease10.3
39peripheral vascular disease10.3
40generalized atherosclerosis10.3
41periodontitis10.3
42klippel-trenaunay syndrome10.2
43sensorineural hearing loss10.2
44tabes dorsalis10.2
45restless legs syndrome10.2
46hyperhomocysteinemia10.2
47hepatitis a10.2
48autonomic neuropathy10.2
49glaucoma10.2
50hepatitis10.2

Graphical network of the top 20 diseases related to Impotence:



Diseases related to impotence

Clinical Features for Impotence

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Drugs & Therapeutics for Impotence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Impotence

Drug clinical trials:

Search ClinicalTrials for Impotence

Search NIH Clinical Center for Impotence

Search CenterWatch for Impotence

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Impotence

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Anatomical Context for Impotence

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Sources:
32MalaCards
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MalaCards organs/tissues related to Impotence:

32
Kidney, Brain, Prostate, Testes, Endothelial, Spinal cord, Smooth muscle, Heart, Eye, Skin, Temporal lobe

Animal Models for Impotence or affiliated genes

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Publications for Impotence

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Sources:
50PubMed
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Articles related to Impotence:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
The role of interventional radiology in the diagnosis and management of male impotence. (23188557)
2013
2
Lue TF, Zeineh SJ, Scmidt RA and Tanagho EA--Neuroanatomy of penile erection: its relevance to iatrogenic impotence. 1984. (21284826)
2011
3
Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A(2B) receptor dysfunction. (16837560)
2006
4
Third drug for impotence. (15032184)
2004
5
Clinical observation on the therapeutic effects of heavy moxibustion plus point-injection in treatment of impotence. (15270266)
2004
6
Recent findings in impotence research: 10th world congress of the international society for sexual and impotence research, montreal, Canada, september 22-26, 2002. (16985628)
2003
7
The link between smoking and impotence: two decades of evidence. (11394947)
2001
8
Impotence and genital numbness in cyclists. (11531032)
2001
9
African Society for Impotence Research--second continental meeting. (10982315)
2000
10
Male impotence. (10703830)
2000
11
Proceedings of the 7th Bienniel Asia-Pacific Meeting on Impotence. Tokyo, Japan, October 26-30, 1999. Abstracts. (10907056)
2000
12
Asthma and impotence. The story of an unexpected connection. (11503241)
2000
13
Embolotherapy for venous impotence: use of ethanol. (10997470)
2000
14
Recurrent fainting, dysesthesia, and impotence. (10418550)
1999
15
Current treatment of impotence: Viagra and other options. (10347410)
1999
16
The role of Viagra in the treatment of male impotence in ESRD. (10418355)
1999
17
Management of impotence in primary care. (9559248)
1998
18
When patients request the impotence pill. (9721579)
1998
19
Technetium-99m-labelled RBC erection penogram to differentiate psychogenic from vasculogenic impotence. (9792979)
1998
20
A pill for impotence. (9580654)
1998
21
Take care when prescribing new drug to treat impotence, MDs warned. (9676555)
1998
22
Sildenafil (Viagra): the new pill for impotence. (9644499)
1998
23
Pharmacologically induced penile erections in the assessment and treatment of erectile impotence: a preliminary study of 100 patients. (9257465)
1997
24
Can NPTR data predict the cause of organic impotence? (9287436)
1997
25
The use of the vacuum erection device in the management of erectile impotence. (8981174)
1996
26
Corpus cavernosum electromyography (CC-EMG): a new technique in the diagnostic work-up of impotence. (9089051)
1996
27
Ultrasound evaluation of the penis for assessment of impotence. (8884525)
1996
28
Impotence as a cardinal sign in the thromboangiitis obliterans diagnosis. (8608695)
1995
29
Management of impotence due to spinal cord injury using low dose papaverine. (7753572)
1995
30
Penile dorsal vein arterialization in managing venogenic impotence. (9118385)
1995
31
Alprostadil for erectile impotence. (8529540)
1995
32
Does compression of the base of the penis improve the efficacy of intracavernosal injection of prostaglandin E1 for impotence? A randomized controlled study. (7670590)
1995
33
Impotence. (8189564)
1994
34
Vacuum constriction devices in erectile dysfunction: acceptance and effectiveness in patients with impotence of organic or mixed aetiology. (8044504)
1994
35
Adenosine: a new agent in the diagnosis of impotence. (7795719)
1994
36
Effectiveness of platinum wire microcoils for venous occlusion: a study on patients treated for venogenic impotence. (8087837)
1994
37
Psychogenic versus primary organic impotence. (7951703)
1994
38
Multidisciplinary evaluation of diabetic impotence. (7713129)
1994
39
Diagnosis and treatment of vasculogenic impotence. (7618374)
1994
40
Long-term results of penile vein ligation for impotence from venous leakage. (8479020)
1993
41
How is impotence treated with acupuncture? (8246606)
1993
42
Managing impotence in diabetes. Psychological factors remain important. (8401114)
1993
43
Impotence associated with cinnarizine. (8453180)
1993
44
Posttraumatic impotence: magnetic resonance imaging and duplex ultrasound in diagnosis and management. (8479013)
1993
45
Re: Venogenic impotence following dermal graft repair for Peyronie's disease. (1404653)
1992
46
Algorithm for the delineation and treatment of vasculogenic impotence. A review. (2651349)
1989
47
Percutaneous transluminal angioplasty for vasculogenic impotence. (2939130)
1986
48
Automatic determination of penile blood pressure in evaluation of vasculogenic impotence. (7123718)
1982
49
Diagnosis and therapy of vasculogenic impotence. (7420554)
1980
50
Plasma testosterone and testosterone binding affinities in men with impotence, oligospermia, azoospermia, and hypogonadism. (4819173)
1974

Genetic Variations for Impotence

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Expression for genes affiliated with Impotence

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impotence

Search GEO for disease gene expression data for Impotence.

Pathways for genes affiliated with Impotence

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Pathways related to Impotence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NO-dependent CFTR activation (normal and CF)
9.9NOS1, PDE5A

Compounds for genes affiliated with Impotence

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Impotence according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1tamsulosin28 44 1112.3KLK3, ADRA1D
2ment4410.1SHBG, SRD5A1, KLK3
3leuprolide acetate4410.0KLK3, GNRH1, PRL, SHBG
4androstenediol4410.0KLK3, SHBG, SRD5A1
5leuprolide44 59 28 1112.9KLK3, GNRH1, PRL, SRD5A1
6goserelin44 28 1111.9SRD5A1, SHBG, GNRH1, KLK3
7methoxamine28 44 1111.8VIP, ADRA1D, KNG1
817-hydroxyprogesterone44 2410.8SRD5A1, SHBG, PRL, GNRH1
9alfuzosin44 1110.8ADRA1D, SRD5A1, KLK3
10ng-nitro-l-arginine449.8VIP, KNG1, BLVRB, NOS1
11spironolactone49 44 59 28 1113.8KLK3, GNRH1, SHBG, SRD5A1
12tetraethylammonium44 28 1111.8NOS1, KCNMA1, VIP, KNG1
13acetylcholine44 49 28 11 2413.8KCNMA1, KNG1, BLVRB, NOS1
14citrulline44 2410.7KNG1, VIP, BLVRB, NOS1
15dhea449.7KLK3, KCNMA1, PRL, SRD5A1, SHBG
16estrogen449.7KLK3, PDE5A, SRD5A1, ELN
17cyproteroneacetate449.7KLK3, GNRH1, PRL, SRD5A1, SHBG
18flutamide44 59 1111.7GNRH1, SHBG, KLK3, SRD5A1, PRL
19terazosin44 1110.7KLK3, SRD5A1, ADRA1D
20dehydroepiandrosterone sulfate449.7KLK3, GNRH1, PRL, SHBG, SRD5A1
21sildenafil44 49 28 11 2413.6SRD5A1, SHBG, PDE5A, VIP, NOS1
22bromocriptine28 44 1111.6VIP, GNRH1, ADRA1D, PRL, SHBG
23phentolamine28 44 1111.6ADRA1D, PDE5A, GNRH1, VIP
24thyroxine44 2410.5GNRH1, KLK3, PRL, SHBG, VIP
255-hydroxytryptamine449.5GNRH1, VIP, KNG1, PRL, NOS1
26phenylephrine44 28 11 2412.5ADRA1D, KNG1, NOS1, KCNMA1, VIP
27guanylate449.5KCNMA1, NOS1, KNG1, PDE5A, VIP
28l-nmma449.5KNG1, NOS1, KCNMA1, VIP
29dihydrotestosterone44 28 11 2412.5KLK3, VIP, GNRH1, SHBG, PRL, SRD5A1
30nifedipine44 49 28 1112.5ELN, VIP, KCNMA1, GNRH1, KNG1
31nitroglycerin44 1110.5BLVRB, NOS1, VIP, KNG1, PDE5A
32progestins449.4SHBG, GNRH1, SRD5A1, KLK3
33isoproterenol44 1110.3GNRH1, PDE5A, NOS1, KNG1, VIP, KCNMA1
34methacholine44 1110.3VIP, KNG1, NOS1, KCNMA1
35gnrh449.3SRD5A1, GNRH1, VIP, KLK3, SHBG, BLVRB
36epinephrine44 11 2411.3PRL, GNRH1, ADRA1D, SHBG, KLK3, VIP
37norepinephrine44 11 2411.2ADRA1D, ENTPD1, PRL, VIP, GNRH1, PDE5A
38prostacyclin449.2VIP, KCNMA1, KNG1, ENTPD1, PDE5A
39gaba449.2NOS1, VIP, KCNMA1, GNRH1, BLVRB, SRD5A1
40formaldehyde44 2410.2ELN, NOS1, BLVRB, KLK3, GNRH1
41histamine44 28 2411.1PDE5A, ELN, VIP, KCNMA1, NOS1, KNG1
42cgmp44 2810.0VIP, NOS1, KCNMA1, PDE5A, BLVRB, KNG1
43estradiol44 11 2411.0KCNMA1, KLK3, GNRH1, PRL, SHBG, BLVRB
44dexamethasone44 49 28 1111.9VIP, GNRH1, PRL, SRD5A1, SHBG, NOS1
45dopamine44 28 11 2411.9SHBG, BLVRB, NOS1, SRD5A1, PDE5A, GNRH1
46adenylate448.9VIP, KCNMA1, GNRH1, KNG1, SHBG, BLVRB
47indomethacin44 59 28 1111.8PDE5A, KNG1, BLVRB, NOS1, SRD5A1, ELN
48sodium nitroprusside448.7KCNMA1, GNRH1, PDE5A, KNG1, ELN, BLVRB
49arginine448.3ELN, SHBG, KCNMA1, PRL, KNG1, VIP
50testosterone44 59 11 2411.3ELN, GNRH1, SRD5A1, NOS1, KLK3, VIP

GO Terms for genes affiliated with Impotence

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Sources:
16Gene Ontology
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Cellular components related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.9ELN, SHBG, PRL, KNG1, GNRH1, VIP

Biological processes related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of potassium ion transportGO:04326710.1NOS1, VIP
2multicellular organismal response to stressGO:03355510.1NOS1, PRL
3N-terminal protein myristoylationGO:0064999.7NMT2, NMT1
4ovulation cycleGO:0426989.7PRL, GNRH1
5protein lipoylationGO:0092499.7NMT1, NMT2
6blood coagulationGO:0075969.1KNG1, ENTPD1, NOS1, KCNMA1, PDE5A

Molecular functions related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8PRL, GNRH1, VIP
2glycylpeptide N-tetradecanoyltransferase activityGO:0043799.3NMT2, NMT1

Products for genes affiliated with Impotence

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Impotence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet