MCID: IMP005
MIFTS: 55

Impotence malady

Mental diseases, Reproductive diseases categories
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Summaries for Impotence

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Erectile dysfunction (ed) is a common type of male sexual dysfunction. it is when a man has trouble getting or keeping an erection. ed becomes more common as you get older. but it's not a natural part of aging. some people have trouble speaking with their doctors about sex. but if you have ed, you should tell your doctor. ed can be a sign of health problems. it may mean your blood vessels are clogged. it may mean you have nerve damage from diabetes. if you don't see your doctor, these problems will go untreated. your doctor can offer several new treatments for ed. for many men, the answer is as simple as taking a pill. getting more exercise, losing weight, or stopping smoking may also help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Impotence, also known as erectile dysfunction, is related to prostatitis and prostate cancer. An important gene associated with Impotence is VIP (vasoactive intestinal peptide), and among its related pathways are NO dependent CFTR activation normal and CF and Salivary secretion. The drugs methyltestosterone and papaverine and the compounds ment and androstenediol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and prostate, and related mouse phenotype reproductive system.

Wikipedia:65 Erectile dysfunction (ED) or impotence is sexual dysfunction characterized by the inability to develop... more...

Aliases & Classifications for Impotence

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Reproductive diseases


Aliases & Descriptions:

impotence 8 10 45
erectile dysfunction 8 45 34 62
sexual impotence 8


External Ids:

Disease Ontology8 DOID:1875

Related Diseases for Impotence

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impotence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.8KLK3, PDE5A, SRD5A1
2prostate cancer30.6SRD5A1, KLK3
3obesity30.5SHBG, SRD5A1, PDE5A, KNG1, NOS1
4atherosclerosis30.5SHBG, ELN, PDE5A, KNG1, NOS1
5coronary artery disease30.5PDE5A, KNG1, NOS1
6hyperhomocysteinemia30.3ELN, KNG1
7premature ejaculation30.2PDE5A
8varicocele30.2SHBG, PRL
9oligospermia30.2PRL, SRD5A1
10hyperthyroidism30.2SHBG, PRL, SRD5A1
11male infertility30.1PRL, SHBG
12aneurysm30.1ELN, KNG1
13rhinitis30.1VIP, PDE5A, KNG1
14adenoma30.1SHBG, PRL, SRD5A1, NOS1
15gynecomastia30.1KLK3, SRD5A1, PRL, SHBG
16hypogonadism30.1SHBG, PRL, PDE5A, KLK3
17essential hypertension30.1SHBG, ADRA1D, KNG1
18myocardial infarction30.1SHBG, PDE5A, KNG1, NOS1
19hypertension30.1ADRA1D, PDE5A, KNG1
20asthma30.1NOS1, KNG1, VIP, KCNMA1
21penile disease30.0PRL, KLK3
22acromegaly30.0PRL, VIP, SHBG
23cryptorchidism29.9SHBG, SRD5A1
24azoospermia29.9SHBG, PRL, SRD5A1
25hyperprolactinemia29.9SHBG, VIP, PRL, SRD5A1
26vascular disease29.8KNG1, PDE5A, ELN
27vasculogenic impotence10.9
28anterior ischemic optic neuropathy10.5
29type 2 diabetes mellitus10.4
30paine syndrome10.4
31urethritis10.3
32peyronie's disease10.3
33peripheral vascular disease10.3
34generalized atherosclerosis10.3
35artery disease10.3
36periodontitis10.3
37infertility10.2
38diabetes mellitus10.2
39blindness10.2
40klippel-trenaunay syndrome10.2
41non-arteritic anterior ischemic optic neuropathy10.2
42arteritic anterior ischemic optic neuropathy10.2
43sensorineural hearing loss10.2
44tabes dorsalis10.2
45restless legs syndrome10.2
46autonomic neuropathy10.2
47glaucoma10.2
48hepatitis10.2
49myotonic dystrophy10.2
50neurofibroma10.2

Graphical network of the top 20 diseases related to Impotence:



Diseases related to impotence

Symptoms for Impotence

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Drugs & Therapeutics for Impotence

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Impotence

Search NIH Clinical Center for Impotence

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Impotence

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Anatomical Context for Impotence

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Sources:
33MalaCards
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MalaCards organs/tissues related to Impotence:

33
Kidney, Brain, Prostate, Testes, Endothelial, Spinal cord, Heart, Smooth muscle, Skin, Eye, Temporal lobe

Animal Models for Impotence or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Impotence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.7NOS1, SRD5A1, PRL, VIP, KCNMA1

Publications for Impotence

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Sources:
52PubMed
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Articles related to Impotence:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
The impotence of price controls: failed attempts to constrain pharmaceutical expenditures in Greece. (20884073)
2011
2
Impotence and libido in Arabic medical literature. (18792558)
2008
3
On call. Whenever I ride my bike for more than an hour or so, I notice numbness in my penis. I know that can lead to impotence, so I've stopped taking long rides. But now I see some policemen in my town patrolling on bikes all day long. Will they end up with problems? (17288024)
2006
4
Abstracts of the VIII Congress of the Latin American Society for Sexual and Impotence Research (SLAIS) December 1-3, 2005. (16497241)
2006
5
The impotence of cumulative effects assessment in Canada: ailments and ideas for redeployment. (16362488)
2006
6
Natural remedies for impotence in medieval Persia. (14963476)
2004
7
The role of free radical in the pathogenesis of impotence in streptozotocin-induced diabetic rats. (12728463)
2003
8
Recent data upon impotence, incontinence and quality of life issues concerning radical prostatectomy. (12768997)
2003
9
Hoaxes: supreme fakers. The doctor's got your goat. In the 1920s, a testicle transplant was a 'cure' for impotence. (12219559)
2002
10
Urethral wands for impotence. (11251540)
2001
11
The link between smoking and impotence: two decades of evidence. (11394947)
2001
12
Embolization of the deep dorsal vein for the treatment of erectile impotence due to veno-occlusive dysfunction. (10647658)
2000
13
African Society for Impotence Research--second continental meeting. (10982315)
2000
14
Comparative tolerability and efficacy of treatments for impotence. (10082071)
1999
15
Maximisation of the erectile response in the investigation of impotence. (10098951)
1999
16
Biking and sex: can riding cause impotence? (10368542)
1999
17
More caution advised in using impotence drug Viagra. (10067142)
1999
18
How psychiatrists can build new therapies for impotence. (9501884)
1998
19
Help-seeking decisions among men with impotence. (9801109)
1998
20
Impotence after sclerotherapy of haemorrhoids: case reports. (9040388)
1997
21
Is diabetic neuropathy responsible for diabetic impotence? (9188140)
1997
22
Biochemical alterations of the tunica albuginea in impotence. (9334600)
1997
23
Anxiety-induced failure in erectile response to intracorporeal prostaglandin-E1 in non-organic male impotence: a new diagnostic approach. (9292324)
1997
24
The use of the vacuum erection device in the management of erectile impotence. (8981174)
1996
25
Anxiety-induced failure in erectile response to intracorporeal prostaglandin-E1 in non-organic male impotence: a new diagnostic approach. (8985780)
1996
26
Impotence. (8632552)
1996
27
Blunt cavernous nerve injury: A new animal model mimicking postradical prostatectomy neurogenic impotence. (21224162)
1996
28
Trial of pentoxifylline for diabetic impotence. (7555478)
1995
29
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
30
Impotence as a cardinal sign in the thromboangiitis obliterans diagnosis. (8608695)
1995
31
Management of impotence in a developing country. (7498020)
1995
32
The place of acupuncture in the management of psychogenic impotence. (7925530)
1994
33
Routine prolactin measurement is not necessary in the initial evaluation of male impotence. (8077999)
1994
34
Impotence: diagnosis and management of male erectile dysfunction. (8173405)
1994
35
Impotence. (8189564)
1994
36
Experience with buccal phentolamine mesylate for impotence. (7517275)
1994
37
Some mythologic, religious, and cultural aspects of impotence before the present modern era. (7735361)
1994
38
Nitric oxide synthase: a new diagnostic tool for neurogenic impotence. (7692661)
1993
39
Smoking and erectile impotence. (8207302)
1993
40
Consensus development conference statement. National Institutes of Health. Impotence. December 7-9, 1992. (8173631)
1993
41
Treatment of organic impotence with penile prosthesis in renal transplant patients. (8420073)
1993
42
Impotence. (8379880)
1993
43
Endocrine causes of impotence. (7507006)
1993
44
A study on the mechanical reliability of the Dacomed snap gauge: implications for the differentiation between organic and psychogenic impotence. (1482278)
1992
45
The role of colour duplex ultrasonography in the diagnosis of vasculogenic impotence. (1747732)
1991
46
Evaluation of vasculogenic impotence. (3278477)
1988
47
Percutaneous transluminal angioplasty for vasculogenic impotence. (2939130)
1986
48
Internal iliac artery revascularization in the treatment of vasculogenic impotence. (3970665)
1985
49
Transluminal angioplasty for treatment of vasculogenic impotence. (6211967)
1982
50
Proceedings: impotence and urethral stricture. (1148630)
1975

Variations for Impotence

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Expression for genes affiliated with Impotence

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impotence

Search GEO for disease gene expression data for Impotence.

Pathways for genes affiliated with Impotence

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Sources:
50PathCards, 60Thomson Reuters, 30KEGG, 55Reactome
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Compounds for genes affiliated with Impotence

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Impotence according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1ment459.7KLK3, SRD5A1, SHBG
2androstenediol459.6SRD5A1, SHBG, KLK3
3leuprolide acetate459.6KLK3, SHBG, PRL
4apamin45 61 2911.6KNG1, KCNMA1, VIP
5goserelin45 29 1111.6SRD5A1, KLK3, SHBG
6leuprolide45 61 29 1112.6PRL, SRD5A1, KLK3
7methoxamine45 29 1111.6KNG1, ADRA1D, VIP
8bromocriptine45 29 1111.5PRL, ADRA1D, VIP, SHBG
9alfuzosin45 1110.5KLK3, SRD5A1, ADRA1D
10hydroxyflutamide45 2910.4KLK3, SHBG, SRD5A1
11cyproteroneacetate459.4SHBG, PRL, KLK3, SRD5A1
12flutamide45 61 1111.4SHBG, KLK3, SRD5A1, PRL
13tetraethylammonium45 29 1111.4VIP, KCNMA1, NOS1, KNG1
14methacholine45 51 1111.4NOS1, KNG1, VIP, KCNMA1
15terazosin45 1110.4KLK3, ADRA1D, SRD5A1
16l-nmma459.4VIP, KNG1, NOS1, KCNMA1
17dehydroepiandrosterone sulfate459.4SHBG, PRL, KLK3, SRD5A1
18finasteride45 61 24 1112.3SRD5A1, SHBG, KLK3
19papaverine45 3 1111.3PDE5A, VIP, KNG1
20phentolamine45 29 1111.2PDE5A, ADRA1D, VIP
21dihydrotestosterone45 29 24 1112.1PRL, SHBG, VIP, SRD5A1, KLK3
228-bromo cgmp459.1PDE5A, VIP, KCNMA1
23dhea459.1PRL, SRD5A1, KLK3, SHBG, KCNMA1
24epinephrine45 24 1111.0KLK3, PRL, ADRA1D, VIP, SHBG
25ng-nitro-l-arginine459.0BLVRB, NOS1, VIP, KNG1
26citrulline45 2410.0KNG1, BLVRB, NOS1, VIP
27phenylephrine45 29 24 1112.0KNG1, KCNMA1, VIP, ADRA1D, NOS1
28sildenafil29 45 51 24 1112.9SRD5A1, PDE5A, VIP, SHBG, NOS1
29tamsulosin45 29 1110.9KLK3, PDE5A, ADRA1D, SRD5A1
30guanylate458.8KNG1, VIP, PDE5A, NOS1, KCNMA1
31isoproterenol45 119.8KCNMA1, NOS1, KNG1, PDE5A, VIP
32gaba458.5VIP, NOS1, KCNMA1, SRD5A1, BLVRB
33histamine45 29 2410.4ELN, NOS1, VIP, KCNMA1, KNG1, PDE5A
34nitroglycerin45 119.4NOS1, KNG1, PDE5A, VIP, BLVRB
35dexamethasone45 51 29 1111.4PRL, VIP, SHBG, ELN, SRD5A1, KLK3
36gnrh458.4KLK3, SRD5A1, PRL, SHBG, BLVRB, VIP
37adenylate458.2VIP, NOS1, BLVRB, KNG1, SHBG, KCNMA1
38estradiol45 24 1110.2SHBG, BLVRB, PRL, KLK3, SRD5A1, KCNMA1
39steroid458.1KCNMA1, BLVRB, SRD5A1, PRL, SHBG, KLK3
40acetylcholine45 51 29 24 1112.0BLVRB, KCNMA1, PDE5A, NOS1, VIP, KNG1
41norepinephrine45 24 119.8NOS1, KNG1, PDE5A, PRL, ADRA1D, VIP
42dopamine45 29 24 1110.8SHBG, PRL, VIP, SRD5A1, PDE5A, NOS1
43vegf457.7PDE5A, KLK3, NOS1, ELN, SRD5A1, VIP
44sodium nitroprusside457.7VIP, KCNMA1, BLVRB, ELN, PDE5A, KNG1
45cgmp45 298.6NOS1, KNG1, ELN, PDE5A, VIP, KCNMA1
46nitric oxide45 24 119.6BLVRB, VIP, KCNMA1, PDE5A, KNG1, NOS1
47indomethacin45 29 61 1110.5BLVRB, NOS1, KNG1, PDE5A, SRD5A1, ELN
48estrogen457.5KLK3, NOS1, PRL, ELN, SRD5A1, PDE5A
49arginine457.1SHBG, BLVRB, KCNMA1, VIP, PRL, ELN
50testosterone45 61 24 1110.0BLVRB, SHBG, VIP, PRL, ELN, PDE5A

GO Terms for genes affiliated with Impotence

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Sources:
16Gene Ontology
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Cellular components related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4KLK3, KNG1, ELN, PRL, VIP, SHBG

Biological processes related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of potassium ion transportGO:0432679.9NOS1, VIP
2positive regulation of vasodilationGO:0459099.6NOS1, VIP
3cell proliferationGO:0082839.2ELN, PRL, ADRA1D
4blood coagulationGO:0075968.6KCNMA1, PDE5A, KNG1, NOS1

Products for genes affiliated with Impotence

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Sources for Impotence

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet