MCID: IMP005
MIFTS: 55

Impotence malady

Mental diseases, Reproductive diseases categories
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Summaries for Impotence

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MedlinePlus:33 Erectile dysfunction (ed) is a common type of male sexual dysfunction. it is when a man has trouble getting or keeping an erection. ed becomes more common as you get older. but it's not a natural part of aging. some people have trouble speaking with their doctors about sex. but if you have ed, you should tell your doctor. ed can be a sign of health problems. it may mean your blood vessels are clogged. it may mean you have nerve damage from diabetes. if you don't see your doctor, these problems will go untreated. your doctor can offer several new treatments for ed. for many men, the answer is as simple as taking a pill. getting more exercise, losing weight, or stopping smoking may also help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Impotence, also known as erectile dysfunction, is related to prostate cancer and prostatitis. An important gene associated with Impotence is VIP (vasoactive intestinal peptide), and among its related pathways are NO dependent CFTR activation normal and CF and Salivary secretion. The drugs methyltestosterone and papaverine and the compounds ment and androstenediol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and prostate, and related mouse phenotype reproductive system.

Wikipedia:65 Erectile dysfunction (ED) or impotence is sexual dysfunction characterized by the inability to develop... more...

Aliases & Classifications for Impotence

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Impotence, Aliases & Descriptions:

Name: Impotence 8 10 44
Erectile Dysfunction 8 44 33 62
 
Sexual Impotence 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Reproductive diseases


External Ids:

Disease Ontology8 DOID:1875

Related Diseases for Impotence

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Diseases related to Impotence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer31.0SRD5A1, KLK3
2prostatitis31.0SRD5A1, PDE5A, KLK3
3premature ejaculation30.8PDE5A
4varicocele30.7PRL, SHBG
5oligospermia30.6PRL, SRD5A1
6hyperthyroidism30.5SHBG, SRD5A1, PRL
7male infertility30.4SHBG, PRL
8penile disease30.4KLK3, PRL
9obesity30.4NOS1, KNG1, SHBG, PDE5A, SRD5A1
10rhinitis30.3PDE5A, VIP, KNG1
11acromegaly30.3VIP, PRL, SHBG
12cryptorchidism30.3SRD5A1, SHBG
13azoospermia30.3SRD5A1, PRL, SHBG
14gynecomastia30.2PRL, KLK3, SRD5A1, SHBG
15adenoma30.2SHBG, NOS1, PRL, SRD5A1
16hypogonadism30.2KLK3, PDE5A, SHBG, PRL
17hyperhomocysteinemia30.2ELN, KNG1
18essential hypertension30.1SHBG, ADRA1D, KNG1
19atherosclerosis30.1ELN, NOS1, KNG1, PDE5A, SHBG
20myocardial infarction30.1PDE5A, NOS1, SHBG, KNG1
21hyperprolactinemia30.1VIP, SHBG, PRL, SRD5A1
22hypertension30.0PDE5A, KNG1, ADRA1D
23asthma30.0KNG1, NOS1, KCNMA1, VIP
24aneurysm30.0ELN, KNG1
25chronic obstructive pulmonary disease29.9SHBG, ELN, PDE5A
26vascular disease29.7KNG1, ELN, PDE5A
27vasculogenic impotence10.9
28ischemic optic neuropathy10.5
29anterior ischemic optic neuropathy10.5
30ischemic heart disease10.4
31hypogonadism, hypergonadotropic10.4PRL, SHBG
32partial androgen insensitivity syndrome10.4SHBG, SRD5A1
33type 2 diabetes mellitus10.4
34artery disease10.4
35ovarian disease10.4PRL, SHBG
36androgenetic alopecia10.4SHBG, SRD5A1
37androgen insensitivity syndrome10.4SRD5A1, SHBG
38amenorrhea10.4PRL, SHBG
39premature ovarian failure10.3PRL, SHBG
40neuroendocrine tumor10.3VIP, PRL
41peyronie's disease10.3
42urethritis10.3
43emphysema due to aat deficiency10.3ADRA1D
44precocious puberty10.3SHBG, PRL
45prostatic adenoma10.3SRD5A1, KLK3
46urinary tract obstruction10.3KLK3, SRD5A1
47peripheral vascular disease10.3
48generalized atherosclerosis10.3
49periodontitis10.3
50prostate disease10.3SRD5A1, KLK3

Graphical network of the top 20 diseases related to Impotence:



Diseases related to impotence

Symptoms for Impotence

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Drugs & Therapeutics for Impotence

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Drug clinical trials:

Search ClinicalTrials for Impotence

Search NIH Clinical Center for Impotence

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Impotence

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Anatomical Context for Impotence

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MalaCards organs/tissues related to Impotence:

32
Kidney, Brain, Prostate, Testes, Endothelial, Spinal cord, Heart, Smooth muscle, Eye, Skin, Temporal lobe

Animal Models for Impotence or affiliated genes

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MGI Mouse Phenotypes related to Impotence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.7NOS1, SRD5A1, PRL, VIP, KCNMA1

Publications for Impotence

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Articles related to Impotence:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
The impotence of price controls: failed attempts to constrain pharmaceutical expenditures in Greece. (20884073)
2011
2
Impotence and libido in Arabic medical literature. (18792558)
2008
3
On call. Whenever I ride my bike for more than an hour or so, I notice numbness in my penis. I know that can lead to impotence, so I've stopped taking long rides. But now I see some policemen in my town patrolling on bikes all day long. Will they end up with problems? (17288024)
2006
4
Abstracts of the VIII Congress of the Latin American Society for Sexual and Impotence Research (SLAIS) December 1-3, 2005. (16497241)
2006
5
The impotence of cumulative effects assessment in Canada: ailments and ideas for redeployment. (16362488)
2006
6
Natural remedies for impotence in medieval Persia. (14963476)
2004
7
The role of free radical in the pathogenesis of impotence in streptozotocin-induced diabetic rats. (12728463)
2003
8
Recent data upon impotence, incontinence and quality of life issues concerning radical prostatectomy. (12768997)
2003
9
Hoaxes: supreme fakers. The doctor's got your goat. In the 1920s, a testicle transplant was a 'cure' for impotence. (12219559)
2002
10
Urethral wands for impotence. (11251540)
2001
11
The link between smoking and impotence: two decades of evidence. (11394947)
2001
12
Embolization of the deep dorsal vein for the treatment of erectile impotence due to veno-occlusive dysfunction. (10647658)
2000
13
African Society for Impotence Research--second continental meeting. (10982315)
2000
14
Comparative tolerability and efficacy of treatments for impotence. (10082071)
1999
15
Maximisation of the erectile response in the investigation of impotence. (10098951)
1999
16
Biking and sex: can riding cause impotence? (10368542)
1999
17
More caution advised in using impotence drug Viagra. (10067142)
1999
18
How psychiatrists can build new therapies for impotence. (9501884)
1998
19
Help-seeking decisions among men with impotence. (9801109)
1998
20
Impotence after sclerotherapy of haemorrhoids: case reports. (9040388)
1997
21
Is diabetic neuropathy responsible for diabetic impotence? (9188140)
1997
22
Biochemical alterations of the tunica albuginea in impotence. (9334600)
1997
23
The use of the vacuum erection device in the management of erectile impotence. (8981174)
1996
24
Anxiety-induced failure in erectile response to intracorporeal prostaglandin-E1 in non-organic male impotence: a new diagnostic approach. (8985780)
1996
25
Impotence. (8632552)
1996
26
Blunt cavernous nerve injury: A new animal model mimicking postradical prostatectomy neurogenic impotence. (21224162)
1996
27
Trial of pentoxifylline for diabetic impotence. (7555478)
1995
28
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
29
Impotence as a cardinal sign in the thromboangiitis obliterans diagnosis. (8608695)
1995
30
Management of impotence in a developing country. (7498020)
1995
31
The place of acupuncture in the management of psychogenic impotence. (7925530)
1994
32
Routine prolactin measurement is not necessary in the initial evaluation of male impotence. (8077999)
1994
33
Impotence: diagnosis and management of male erectile dysfunction. (8173405)
1994
34
Impotence. (8189564)
1994
35
Experience with buccal phentolamine mesylate for impotence. (7517275)
1994
36
Some mythologic, religious, and cultural aspects of impotence before the present modern era. (7735361)
1994
37
Nitric oxide synthase: a new diagnostic tool for neurogenic impotence. (7692661)
1993
38
Smoking and erectile impotence. (8207302)
1993
39
Management of impotence. Diagnostic considerations and therapeutic options. (8446527)
1993
40
Consensus development conference statement. National Institutes of Health. Impotence. December 7-9, 1992. (8173631)
1993
41
Treatment of organic impotence with penile prosthesis in renal transplant patients. (8420073)
1993
42
Impotence. (8379880)
1993
43
Endocrine causes of impotence. (7507006)
1993
44
A study on the mechanical reliability of the Dacomed snap gauge: implications for the differentiation between organic and psychogenic impotence. (1482278)
1992
45
The role of colour duplex ultrasonography in the diagnosis of vasculogenic impotence. (1747732)
1991
46
Evaluation of vasculogenic impotence. (3278477)
1988
47
Percutaneous transluminal angioplasty for vasculogenic impotence. (2939130)
1986
48
Internal iliac artery revascularization in the treatment of vasculogenic impotence. (3970665)
1985
49
Transluminal angioplasty for treatment of vasculogenic impotence. (6211967)
1982
50
Proceedings: impotence and urethral stricture. (1148630)
1975

Variations for Impotence

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Expression for genes affiliated with Impotence

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Expression patterns in normal tissues for genes affiliated with Impotence

Search GEO for disease gene expression data for Impotence.

Pathways for genes affiliated with Impotence

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Compounds for genes affiliated with Impotence

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Compounds related to Impotence according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1ment449.7KLK3, SRD5A1, SHBG
2androstenediol449.6SRD5A1, SHBG, KLK3
3leuprolide acetate449.6KLK3, SHBG, PRL
4apamin44 61 2811.6KNG1, KCNMA1, VIP
5goserelin44 28 1111.6SRD5A1, KLK3, SHBG
6leuprolide44 61 28 1112.6PRL, SRD5A1, KLK3
7methoxamine44 28 1111.6KNG1, ADRA1D, VIP
8bromocriptine44 28 1111.5PRL, ADRA1D, VIP, SHBG
9alfuzosin44 1110.5KLK3, SRD5A1, ADRA1D
10hydroxyflutamide44 2810.4KLK3, SHBG, SRD5A1
11cyproteroneacetate449.4SHBG, PRL, KLK3, SRD5A1
12flutamide44 61 1111.4SHBG, KLK3, SRD5A1, PRL
13tetraethylammonium44 28 1111.4VIP, KCNMA1, NOS1, KNG1
14methacholine44 50 1111.4NOS1, KNG1, VIP, KCNMA1
15terazosin44 1110.4KLK3, ADRA1D, SRD5A1
16l-nmma449.4VIP, KNG1, NOS1, KCNMA1
17dehydroepiandrosterone sulfate449.4SHBG, PRL, KLK3, SRD5A1
18finasteride44 61 24 1112.3SRD5A1, SHBG, KLK3
19papaverine44 2 1111.3PDE5A, VIP, KNG1
20phentolamine44 28 1111.2PDE5A, ADRA1D, VIP
21dihydrotestosterone44 28 24 1112.1PRL, SHBG, VIP, SRD5A1, KLK3
228-bromo cgmp449.1PDE5A, VIP, KCNMA1
23dhea449.1PRL, SRD5A1, KLK3, SHBG, KCNMA1
24epinephrine44 24 1111.0KLK3, PRL, ADRA1D, VIP, SHBG
25ng-nitro-l-arginine449.0BLVRB, NOS1, VIP, KNG1
26citrulline44 2410.0KNG1, BLVRB, NOS1, VIP
27phenylephrine44 28 24 1112.0KNG1, KCNMA1, VIP, ADRA1D, NOS1
28sildenafil28 44 50 24 1112.9SRD5A1, PDE5A, VIP, SHBG, NOS1
29tamsulosin44 28 1110.9KLK3, PDE5A, ADRA1D, SRD5A1
30guanylate448.8KNG1, VIP, PDE5A, NOS1, KCNMA1
31isoproterenol44 119.8KCNMA1, NOS1, KNG1, PDE5A, VIP
32gaba448.5VIP, NOS1, KCNMA1, SRD5A1, BLVRB
33histamine44 28 2410.4ELN, NOS1, VIP, KCNMA1, KNG1, PDE5A
34nitroglycerin44 119.4NOS1, KNG1, PDE5A, VIP, BLVRB
35dexamethasone44 50 28 1111.4PRL, VIP, SHBG, ELN, SRD5A1, KLK3
36gnrh448.4KLK3, SRD5A1, PRL, SHBG, BLVRB, VIP
37adenylate448.2VIP, NOS1, BLVRB, KNG1, SHBG, KCNMA1
38estradiol44 24 1110.2SHBG, BLVRB, PRL, KLK3, SRD5A1, KCNMA1
39steroid448.1KCNMA1, BLVRB, SRD5A1, PRL, SHBG, KLK3
40acetylcholine44 50 28 24 1112.0BLVRB, KCNMA1, PDE5A, NOS1, VIP, KNG1
41norepinephrine44 24 119.8NOS1, KNG1, PDE5A, PRL, ADRA1D, VIP
42dopamine44 28 24 1110.8SHBG, PRL, VIP, SRD5A1, PDE5A, NOS1
43vegf447.7PDE5A, KLK3, NOS1, ELN, SRD5A1, VIP
44sodium nitroprusside447.7VIP, KCNMA1, BLVRB, ELN, PDE5A, KNG1
45cgmp44 288.6NOS1, KNG1, ELN, PDE5A, VIP, KCNMA1
46nitric oxide44 24 119.6BLVRB, VIP, KCNMA1, PDE5A, KNG1, NOS1
47indomethacin44 28 61 1110.5BLVRB, NOS1, KNG1, PDE5A, SRD5A1, ELN
48estrogen447.5KLK3, NOS1, PRL, ELN, SRD5A1, PDE5A
49arginine447.1SHBG, BLVRB, KCNMA1, VIP, PRL, ELN
50testosterone44 61 24 1110.0BLVRB, SHBG, VIP, PRL, ELN, PDE5A

GO Terms for genes affiliated with Impotence

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Cellular components related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4KLK3, KNG1, ELN, PRL, VIP, SHBG

Biological processes related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of potassium ion transportGO:0432679.9NOS1, VIP
2positive regulation of vasodilationGO:0459099.6NOS1, VIP
3cell proliferationGO:0082839.2ELN, PRL, ADRA1D
4blood coagulationGO:0075968.6KCNMA1, PDE5A, KNG1, NOS1

Products for genes affiliated with Impotence

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Sources for Impotence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet