MCID: IMP005
MIFTS: 55

Impotence malady

Mental diseases, Reproductive diseases categories

Summaries for Impotence

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Erectile dysfunction (ed) is a common type of male sexual dysfunction. it is when a man has trouble getting or keeping an erection. ed becomes more common as you get older. but it's not a natural part of aging. some people have trouble speaking with their doctors about sex. but if you have ed, you should tell your doctor. ed can be a sign of health problems. it may mean your blood vessels are clogged. it may mean you have nerve damage from diabetes. if you don't see your doctor, these problems will go untreated. your doctor can offer several new treatments for ed. for many men, the answer is as simple as taking a pill. getting more exercise, losing weight, or stopping smoking may also help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Impotence, also known as erectile dysfunction, is related to prostatitis and prostate cancer. An important gene associated with Impotence is VIP (vasoactive intestinal peptide), and among its related pathways are NO dependent CFTR activation normal and CF and Salivary secretion. The drugs methyltestosterone and papaverine and the compounds ment and androstenediol have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and prostate, and related mouse phenotype reproductive system.

Wikipedia:66 Erectile dysfunction (ED) or impotence is sexual dysfunction characterized by the inability to develop... more...

Aliases & Classifications for Impotence

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Reproductive diseases


Aliases & Descriptions:

impotence 9 11 46
erectile dysfunction 9 46 35 63
sexual impotence 9


External Ids:

Disease Ontology9 DOID:1875

Related Diseases for Impotence

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Impotence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.8KLK3, PDE5A, SRD5A1
2prostate cancer30.6SRD5A1, KLK3
3obesity30.5SHBG, SRD5A1, PDE5A, KNG1, NOS1
4atherosclerosis30.5SHBG, ELN, PDE5A, KNG1, NOS1
5coronary artery disease30.5PDE5A, KNG1, NOS1
6hyperhomocysteinemia30.3ELN, KNG1
7premature ejaculation30.2PDE5A
8varicocele30.2SHBG, PRL
9oligospermia30.2PRL, SRD5A1
10hyperthyroidism30.2SHBG, PRL, SRD5A1
11male infertility30.1PRL, SHBG
12aneurysm30.1ELN, KNG1
13rhinitis30.1VIP, PDE5A, KNG1
14adenoma30.1SHBG, PRL, SRD5A1, NOS1
15gynecomastia30.1KLK3, SRD5A1, PRL, SHBG
16hypogonadism30.1SHBG, PRL, PDE5A, KLK3
17essential hypertension30.1SHBG, ADRA1D, KNG1
18myocardial infarction30.1SHBG, PDE5A, KNG1, NOS1
19hypertension30.1ADRA1D, PDE5A, KNG1
20asthma30.1NOS1, KNG1, VIP, KCNMA1
21penile disease30.0PRL, KLK3
22acromegaly30.0PRL, VIP, SHBG
23cryptorchidism29.9SHBG, SRD5A1
24azoospermia29.9SHBG, PRL, SRD5A1
25hyperprolactinemia29.9SHBG, VIP, PRL, SRD5A1
26vascular disease29.8KNG1, PDE5A, ELN
27vasculogenic impotence10.9
28anterior ischemic optic neuropathy10.5
29type 2 diabetes mellitus10.4
30paine syndrome10.4
31urethritis10.3
32peyronie's disease10.3
33peripheral vascular disease10.3
34generalized atherosclerosis10.3
35artery disease10.3
36periodontitis10.3
37infertility10.2
38diabetes mellitus10.2
39blindness10.2
40klippel-trenaunay syndrome10.2
41non-arteritic anterior ischemic optic neuropathy10.2
42arteritic anterior ischemic optic neuropathy10.2
43sensorineural hearing loss10.2
44tabes dorsalis10.2
45restless legs syndrome10.2
46autonomic neuropathy10.2
47glaucoma10.2
48hepatitis10.2
49myotonic dystrophy10.2
50neurofibroma10.2

Graphical network of the top 20 diseases related to Impotence:



Diseases related to impotence

Symptoms for Impotence

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Drugs & Therapeutics for Impotence

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Impotence

Drug clinical trials:

Search ClinicalTrials for Impotence

Search NIH Clinical Center for Impotence

Search CenterWatch for Impotence

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Impotence

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Anatomical Context for Impotence

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Sources:
34MalaCards
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MalaCards organs/tissues related to Impotence:

34
Kidney, Brain, Prostate, Testes, Endothelial, Spinal cord, Heart, Smooth muscle, Skin, Eye, Temporal lobe

Animal Models for Impotence or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Impotence:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.7NOS1, SRD5A1, PRL, VIP, KCNMA1

Publications for Impotence

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Sources:
53PubMed
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Articles related to Impotence:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
The impotence of price controls: failed attempts to constrain pharmaceutical expenditures in Greece. (20884073)
2011
2
Impotence and libido in Arabic medical literature. (18792558)
2008
3
On call. Whenever I ride my bike for more than an hour or so, I notice numbness in my penis. I know that can lead to impotence, so I've stopped taking long rides. But now I see some policemen in my town patrolling on bikes all day long. Will they end up with problems? (17288024)
2006
4
Abstracts of the VIII Congress of the Latin American Society for Sexual and Impotence Research (SLAIS) December 1-3, 2005. (16497241)
2006
5
The impotence of cumulative effects assessment in Canada: ailments and ideas for redeployment. (16362488)
2006
6
Natural remedies for impotence in medieval Persia. (14963476)
2004
7
The role of free radical in the pathogenesis of impotence in streptozotocin-induced diabetic rats. (12728463)
2003
8
Recent data upon impotence, incontinence and quality of life issues concerning radical prostatectomy. (12768997)
2003
9
Hoaxes: supreme fakers. The doctor's got your goat. In the 1920s, a testicle transplant was a 'cure' for impotence. (12219559)
2002
10
Urethral wands for impotence. (11251540)
2001
11
The link between smoking and impotence: two decades of evidence. (11394947)
2001
12
Embolization of the deep dorsal vein for the treatment of erectile impotence due to veno-occlusive dysfunction. (10647658)
2000
13
African Society for Impotence Research--second continental meeting. (10982315)
2000
14
Comparative tolerability and efficacy of treatments for impotence. (10082071)
1999
15
Maximisation of the erectile response in the investigation of impotence. (10098951)
1999
16
Biking and sex: can riding cause impotence? (10368542)
1999
17
More caution advised in using impotence drug Viagra. (10067142)
1999
18
How psychiatrists can build new therapies for impotence. (9501884)
1998
19
Help-seeking decisions among men with impotence. (9801109)
1998
20
Impotence after sclerotherapy of haemorrhoids: case reports. (9040388)
1997
21
Is diabetic neuropathy responsible for diabetic impotence? (9188140)
1997
22
Biochemical alterations of the tunica albuginea in impotence. (9334600)
1997
23
Anxiety-induced failure in erectile response to intracorporeal prostaglandin-E1 in non-organic male impotence: a new diagnostic approach. (9292324)
1997
24
The use of the vacuum erection device in the management of erectile impotence. (8981174)
1996
25
Anxiety-induced failure in erectile response to intracorporeal prostaglandin-E1 in non-organic male impotence: a new diagnostic approach. (8985780)
1996
26
Impotence. (8632552)
1996
27
Blunt cavernous nerve injury: A new animal model mimicking postradical prostatectomy neurogenic impotence. (21224162)
1996
28
Trial of pentoxifylline for diabetic impotence. (7555478)
1995
29
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
30
Impotence as a cardinal sign in the thromboangiitis obliterans diagnosis. (8608695)
1995
31
Management of impotence in a developing country. (7498020)
1995
32
The place of acupuncture in the management of psychogenic impotence. (7925530)
1994
33
Routine prolactin measurement is not necessary in the initial evaluation of male impotence. (8077999)
1994
34
Impotence: diagnosis and management of male erectile dysfunction. (8173405)
1994
35
Impotence. (8189564)
1994
36
Experience with buccal phentolamine mesylate for impotence. (7517275)
1994
37
Some mythologic, religious, and cultural aspects of impotence before the present modern era. (7735361)
1994
38
Nitric oxide synthase: a new diagnostic tool for neurogenic impotence. (7692661)
1993
39
Smoking and erectile impotence. (8207302)
1993
40
Consensus development conference statement. National Institutes of Health. Impotence. December 7-9, 1992. (8173631)
1993
41
Treatment of organic impotence with penile prosthesis in renal transplant patients. (8420073)
1993
42
Impotence. (8379880)
1993
43
Endocrine causes of impotence. (7507006)
1993
44
A study on the mechanical reliability of the Dacomed snap gauge: implications for the differentiation between organic and psychogenic impotence. (1482278)
1992
45
The role of colour duplex ultrasonography in the diagnosis of vasculogenic impotence. (1747732)
1991
46
Evaluation of vasculogenic impotence. (3278477)
1988
47
Percutaneous transluminal angioplasty for vasculogenic impotence. (2939130)
1986
48
Internal iliac artery revascularization in the treatment of vasculogenic impotence. (3970665)
1985
49
Transluminal angioplasty for treatment of vasculogenic impotence. (6211967)
1982
50
Proceedings: impotence and urethral stricture. (1148630)
1975

Variations for Impotence

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Expression for genes affiliated with Impotence

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impotence

Search GEO for disease gene expression data for Impotence.

Pathways for genes affiliated with Impotence

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 56Reactome
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Compounds for genes affiliated with Impotence

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Impotence according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1ment469.7KLK3, SRD5A1, SHBG
2androstenediol469.6SRD5A1, SHBG, KLK3
3leuprolide acetate469.6KLK3, SHBG, PRL
4apamin46 62 3011.6KNG1, KCNMA1, VIP
5goserelin46 30 1211.6SRD5A1, KLK3, SHBG
6leuprolide46 62 30 1212.6PRL, SRD5A1, KLK3
7methoxamine46 30 1211.6KNG1, ADRA1D, VIP
8bromocriptine46 30 1211.5PRL, ADRA1D, VIP, SHBG
9alfuzosin46 1210.5KLK3, SRD5A1, ADRA1D
10hydroxyflutamide46 3010.4KLK3, SHBG, SRD5A1
11cyproteroneacetate469.4SHBG, PRL, KLK3, SRD5A1
12flutamide46 62 1211.4SHBG, KLK3, SRD5A1, PRL
13tetraethylammonium46 30 1211.4VIP, KCNMA1, NOS1, KNG1
14methacholine46 52 1211.4NOS1, KNG1, VIP, KCNMA1
15terazosin46 1210.4KLK3, ADRA1D, SRD5A1
16l-nmma469.4VIP, KNG1, NOS1, KCNMA1
17dehydroepiandrosterone sulfate469.4SHBG, PRL, KLK3, SRD5A1
18finasteride46 62 25 1212.3SRD5A1, SHBG, KLK3
19papaverine46 3 1211.3PDE5A, VIP, KNG1
20phentolamine46 30 1211.2PDE5A, ADRA1D, VIP
21dihydrotestosterone46 30 25 1212.1PRL, SHBG, VIP, SRD5A1, KLK3
228-bromo cgmp469.1PDE5A, VIP, KCNMA1
23dhea469.1PRL, SRD5A1, KLK3, SHBG, KCNMA1
24epinephrine46 25 1211.0KLK3, PRL, ADRA1D, VIP, SHBG
25ng-nitro-l-arginine469.0BLVRB, NOS1, VIP, KNG1
26citrulline46 2510.0KNG1, BLVRB, NOS1, VIP
27phenylephrine46 30 25 1212.0KNG1, KCNMA1, VIP, ADRA1D, NOS1
28sildenafil30 46 52 25 1212.9SRD5A1, PDE5A, VIP, SHBG, NOS1
29tamsulosin46 30 1210.9KLK3, PDE5A, ADRA1D, SRD5A1
30guanylate468.8KNG1, VIP, PDE5A, NOS1, KCNMA1
31isoproterenol46 129.8KCNMA1, NOS1, KNG1, PDE5A, VIP
32gaba468.5VIP, NOS1, KCNMA1, SRD5A1, BLVRB
33histamine46 30 2510.4ELN, NOS1, VIP, KCNMA1, KNG1, PDE5A
34nitroglycerin46 129.4NOS1, KNG1, PDE5A, VIP, BLVRB
35dexamethasone46 52 30 1211.4PRL, VIP, SHBG, ELN, SRD5A1, KLK3
36gnrh468.4KLK3, SRD5A1, PRL, SHBG, BLVRB, VIP
37adenylate468.2VIP, NOS1, BLVRB, KNG1, SHBG, KCNMA1
38estradiol46 25 1210.2SHBG, BLVRB, PRL, KLK3, SRD5A1, KCNMA1
39steroid468.1KCNMA1, BLVRB, SRD5A1, PRL, SHBG, KLK3
40acetylcholine46 52 30 25 1212.0BLVRB, KCNMA1, PDE5A, NOS1, VIP, KNG1
41norepinephrine46 25 129.8NOS1, KNG1, PDE5A, PRL, ADRA1D, VIP
42dopamine46 30 25 1210.8SHBG, PRL, VIP, SRD5A1, PDE5A, NOS1
43vegf467.7PDE5A, KLK3, NOS1, ELN, SRD5A1, VIP
44sodium nitroprusside467.7VIP, KCNMA1, BLVRB, ELN, PDE5A, KNG1
45cgmp46 308.6NOS1, KNG1, ELN, PDE5A, VIP, KCNMA1
46nitric oxide46 25 129.6BLVRB, VIP, KCNMA1, PDE5A, KNG1, NOS1
47indomethacin46 30 62 1210.5BLVRB, NOS1, KNG1, PDE5A, SRD5A1, ELN
48estrogen467.5KLK3, NOS1, PRL, ELN, SRD5A1, PDE5A
49arginine467.1SHBG, BLVRB, KCNMA1, VIP, PRL, ELN
50testosterone46 62 25 1210.0BLVRB, SHBG, VIP, PRL, ELN, PDE5A

GO Terms for genes affiliated with Impotence

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Sources:
17Gene Ontology
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Cellular components related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4KLK3, KNG1, ELN, PRL, VIP, SHBG

Biological processes related to Impotence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of potassium ion transportGO:0432679.9NOS1, VIP
2positive regulation of vasodilationGO:0459099.6NOS1, VIP
3cell proliferationGO:0082839.2ELN, PRL, ADRA1D
4blood coagulationGO:0075968.6KCNMA1, PDE5A, KNG1, NOS1

Products for genes affiliated with Impotence

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  • Antibodies
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Sources for Impotence

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet