MCID: IMP006
MIFTS: 44

Impulse Control Disorder malady

Mental diseases category
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Summaries for Impulse Control Disorder

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Disease Ontology:8 A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.

MalaCards based summary: Impulse Control Disorder, also known as impulse control disorders, is related to pathological gambling and parkinson's disease. An important gene associated with Impulse Control Disorder is GRN (granulin), and among its related pathways are Amphetamine addiction and Circadian entrainment. The compounds carbidopa and tyramine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are taste/olfaction and reproductive system.

Wikipedia:65 Impulse control disorder (ICD) is a class of psychiatric disorders characterized by impulsivity ?... more...

Aliases & Classifications for Impulse Control Disorder

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Impulse Control Disorder, Aliases & Descriptions:

Name: Impulse Control Disorder 8
 
Impulse Control Disorders 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:10937
ICD9CM27 312.30
MeSH34 D007174
NCIt39 C34723

Related Diseases for Impulse Control Disorder

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Diseases related to Impulse Control Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1pathological gambling30.7DRD2, SLC6A3
2parkinson's disease30.6COMT, DRD2, SLC6A3
3drug addiction30.3SLC6A3, DRD2
4social phobia30.2DRD2, COMT
5gilles de la tourette syndrome30.2SLC6A3, DRD2
6obsessive-compulsive disorder30.1COMT, DRD2, SLC6A3
7bipolar disorder29.9COMT, DRD2, SLC6A3
8restless legs syndrome10.4
9kleptomania10.4
10oppositional defiant disorder10.4SLC6A3
11trichotillomania10.4
12pyromania10.4
13nicotine dependence10.2DRD2
14kluver-bucy syndrome10.1
15bipolar i disorder10.1
16premature ejaculation10.1
17prolactinoma10.1
18neurotic excoriation10.1
19rem sleep behavior disorder10.1
20intermittent explosive disorder10.1
21alexithymia10.1
22dermatitis10.1
23dystonia10.1
24x-linked dystonia-parkinsonism10.1
25fibromyalgia10.1
26eating disorder10.1COMT, SLC6A3
27memory impairment10.1GRN, SLC6A3
28antisocial personality disorder10.1SLC6A3, DRD2
29striatonigral degeneration10.1SLC6A3, DRD2
30personality disorder10.0DRD2, SLC6A3
31cocaine abuse10.0DRD2, SLC6A3
32drug dependence10.0SLC6A3, DRD2
33cocaine dependence10.0DRD2, SLC6A3
34progressive supranuclear palsy10.0SLC6A3, DRD2
35wilson disease10.0SLC6A3, DRD2
36substance abuse10.0SLC6A3, DRD2
37kidney rhabdoid cancer10.0GRN, COMT
38movement disease10.0SLC6A3, DRD2
39schizoaffective disorder10.0COMT, DRD2
40narcolepsy9.9DRD2, COMT
41multiple system atrophy9.9SLC6A3, DRD2
42dementia9.9COMT, GRN, SLC6A3
43amyotrophic lateral sclerosis type 149.9SLC6A3, GRN
44huntington's disease9.8DRD2, SLC6A3
45mental retardation9.8DRD2, COMT
46substance dependence9.8SLC6A3, DRD2, COMT
47conduct disorder9.8COMT, DRD2, SLC6A3
48alcohol abuse9.8SLC6A3, DRD2, COMT
49anxiety disorder9.8SLC6A3, DRD2, COMT
50attention deficit hyperactivity disorder9.8SLC6A3, DRD2, COMT

Graphical network of the top 20 diseases related to Impulse Control Disorder:



Diseases related to impulse control disorder

Symptoms for Impulse Control Disorder

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Drugs & Therapeutics for Impulse Control Disorder

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Drug clinical trials:

Search ClinicalTrials for Impulse Control Disorder

Search NIH Clinical Center for Impulse Control Disorder

Genetic Tests for Impulse Control Disorder

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Anatomical Context for Impulse Control Disorder

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MalaCards organs/tissues related to Impulse Control Disorder:

32
Eye, Brain, Testes

Animal Models for Impulse Control Disorder or affiliated genes

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MGI Mouse Phenotypes related to Impulse Control Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1SLC6A3, DRD2
2MP:00053898.1SLC6A3, GRN, DRD2, COMT
3MP:00053868.0COMT, DRD2, GRN, SLC6A3
4MP:00036317.9COMT, DRD2, GRN, SLC6A3
5MP:00053767.7SLC6A3, GRN, DRD2, COMT

Publications for Impulse Control Disorder

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Articles related to Impulse Control Disorder:

(show all 39)
idTitleAuthorsYear
1
Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson's disease. (25283069)
2014
2
Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study. (24434037)
2014
3
Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome without impulse control disorder or drug abuse. (25362251)
2014
4
Depression and impulse control disorders in Parkinson's disease: Two sides of the same coin? (24239733)
2014
5
Amantadine and cognitive flexibility: decision making in Parkinson's patients with severe pathological gambling and other impulse control disorders. (24971012)
2014
6
REM sleep behavior disorder: association with motor complications and impulse control disorders in Parkinson's disease. (25085747)
2014
7
Major depression after withdrawing dopamine agonists in two patients with restless legs syndrome and impulse control disorders. (23714418)
2013
8
Three cases of impulse control disorder in Parkinson's disease patients receiving dopamine replacement therapy. (23472375)
2013
9
Impulse control disorder in a patient on long-term treatment with bromocriptine for a macroprolactinoma. (24045609)
2013
10
The role of self-awareness and cognitive dysfunction in Parkinson's disease with and without impulse-control disorder. (23686032)
2013
11
Dopamine agonist-induced impulse control disorders in a patient with prolactinoma. (23261076)
2013
12
Impulse control disorder in a patient with X-linked dystonia-parkinsonism after bilateral pallidal deep brain stimulation. (23920134)
2013
13
Pathological generosity: An atypical impulse control disorder after a left subcortical stroke. (23962063)
2013
14
Transdermal rotigotine causes impulse control disorders in patients with restless legs syndrome. (22030321)
2012
15
Is premature ejaculation an impulse control disorder? (22543077)
2012
16
Comorbid impulse control disorder in bipolar disorder: the role of antidepressants. (22423377)
2012
17
Alexithymia is associated with impulsivity in newly-diagnosed, drug-naA^ve patients with Parkinson's disease: an affective risk factor for the development of impulse-control disorders? (23224478)
2012
18
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders. (22113132)
2012
19
Impulse-control disorders in gilles de la tourette syndrome. (22450610)
2012
20
Prevalence and pharmacological factors associated with impulse-control disorder symptoms in patients with Parkinson disease. (23123689)
2012
21
Zoophilia and impulse control disorder in a patient with Parkinson disease. (22057400)
2012
22
Impulse control disorder comorbidity among patients with bipolar I disorder. (21683175)
2011
23
The emergence of devastating impulse control disorders during dopamine agonist therapy of the restless legs syndrome. (21412200)
2011
24
Obsessive-compulsive disorder, impulse control disorders and drug addiction: common features and potential treatments. (21568361)
2011
25
Dermatitis artefacta in a patient affected by impulse control disorder: case report. (21489363)
2011
26
Tourette's disease with impulse control disorder. (21431012)
2011
27
Pathological gambling: an impulse control disorder? Measurement of impulsivity using neurocognitive tests. (20803888)
2010
28
Swallowing foreign bodies as an example of impulse control disorder in a patient with intellectual disabilities: a case report. (20941350)
2010
29
Kleptomania, an unusual impulsive control disorder in Parkinson's disease? (20202886)
2010
30
Impulse control disorder and piribedil: report of 5 cases. (19959959)
2010
31
Parkinsonism and impulse control disorder: presentation of a new progranulin gene mutation. (19133655)
2009
32
Impulse control disorder behaviors associated with pramipexole used to treat fibromyalgia. (19241148)
2009
33
Impulse control disorders and pathological gambling in patients with Parkinson disease. (18332838)
2008
34
Kleptomania in impulse control disorders, obsessive-compulsive disorder, and bipolar spectrum disorder: clinical and therapeutic implications. (12686000)
2003
35
Tiagabine in the Management of Postencephalitic Epilepsy and Impulse Control Disorder. (12609422)
2002
36
Social phobia as a comorbid condition in sex offenders with paraphilia or impulse control disorder. (11504324)
2001
37
Internet addiction associated with features of impulse control disorder: is it a real psychiatric disorder? (11686127)
2001
38
Conceptual issues in trichotillomania, a prototypical impulse control disorder. (11122936)
2000
39
Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. (10823300)
2000

Variations for Impulse Control Disorder

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Expression for genes affiliated with Impulse Control Disorder

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Expression patterns in normal tissues for genes affiliated with Impulse Control Disorder

Search GEO for disease gene expression data for Impulse Control Disorder.

Pathways for genes affiliated with Impulse Control Disorder

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Pathways related to Impulse Control Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1SLC6A3, DRD2
2
Show member pathways
8.5SLC6A3, DRD2, COMT

Compounds for genes affiliated with Impulse Control Disorder

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Compounds related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1carbidopa44 2810.7SLC6A3, COMT
2tyramine44 28 2411.6SLC6A3, COMT
3fluvoxamine44 50 1111.6SLC6A3, COMT
4venlafaxine44 50 24 1112.6COMT, SLC6A3
5selegiline44 1110.6SLC6A3, COMT
6ibzm449.6SLC6A3, DRD2
7alpha-methyl-p-tyrosine449.5SLC6A3, DRD2
8tetrabenazine44 28 61 50 1113.5SLC6A3, DRD2
9d amphetamine449.5SLC6A3, DRD2
10raclopride44 2810.5SLC6A3, DRD2
11piperazine44 1110.5DRD2, SLC6A3
12trimipramine44 50 1111.5DRD2, SLC6A3
13sulpiride44 28 1111.5DRD2, SLC6A3
14paroxetine44 50 28 1112.5SLC6A3, COMT
15reserpine44 28 1111.5SLC6A3, DRD2
16phencyclidine44 28 1111.4DRD2, SLC6A3
17quinpirole44 2810.4DRD2, SLC6A3
18amantadine44 1110.4DRD2, COMT
19antipsychotics509.4COMT, DRD2
20ropinirole44 1110.4DRD2, COMT
21pergolide44 28 1111.4DRD2, COMT
22ketamine44 28 1111.3SLC6A3, DRD2
23cabergoline44 28 1111.3DRD2, COMT
24spec-t449.2SLC6A3, DRD2
25quetiapine44 50 28 24 1113.2SLC6A3, DRD2
26fluoxetine44 50 28 1112.1DRD2, SLC6A3
27amphetamine44 50 1111.0DRD2, SLC6A3
28methylphenidate44 50 1111.0SLC6A3, DRD2, COMT
29maoa449.0SLC6A3, DRD2, COMT
30pramipexole44 28 50 1112.0COMT, DRD2, SLC6A3
31heroin44 50 1111.0SLC6A3, DRD2, COMT
32bupropion50 44 24 1112.0SLC6A3, DRD2, COMT
33apomorphine28 44 1110.9COMT, DRD2, SLC6A3
34bromocriptine44 28 1110.9SLC6A3, DRD2, COMT
35methamphetamine44 50 1110.9SLC6A3, DRD2, COMT
36risperidone44 50 28 61 24 1113.9COMT, DRD2, SLC6A3
376-hydroxydopamine448.9SLC6A3, DRD2, COMT
38mptp448.9COMT, DRD2, SLC6A3
39olanzapine44 50 28 24 1112.9SLC6A3, DRD2, COMT
40levodopa44 119.9COMT, DRD2, SLC6A3
41clozapine44 28 50 1111.9SLC6A3, DRD2, COMT
42morphine44 50 28 1111.9COMT, DRD2, SLC6A3
43cocaine44 119.9COMT, DRD2, SLC6A3
445-hydroxytryptamine448.9SLC6A3, DRD2, COMT
45nicotine44 28 50 1111.9COMT, DRD2, SLC6A3
46nmda44 289.8COMT, DRD2, SLC6A3
47opiate448.8SLC6A3, DRD2
48norepinephrine44 24 1110.8SLC6A3, DRD2, COMT
49dopamine44 28 24 1111.7COMT, DRD2, SLC6A3
50glutamate448.5SLC6A3, DRD2, COMT

GO Terms for genes affiliated with Impulse Control Disorder

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Cellular components related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1SLC6A3, DRD2

Biological processes related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.6SLC6A3, COMT
2neurotransmitter biosynthetic processGO:0421369.5SLC6A3, COMT
3cell deathGO:0082199.4SLC6A3, GRN
4adenohypophysis developmentGO:0219849.4SLC6A3, DRD2
5response to iron ionGO:0100399.4DRD2, SLC6A3
6prepulse inhibitionGO:0601349.3SLC6A3, DRD2
7response to cocaineGO:0422209.2SLC6A3, DRD2
8response to nicotineGO:0350949.2SLC6A3, DRD2
9positive regulation of multicellular organism growthGO:0400189.1DRD2, SLC6A3
10sensory perception of smellGO:0076089.0SLC6A3, DRD2
11locomotory behaviorGO:0076268.8SLC6A3, DRD2
12response to drugGO:0424938.7COMT, DRD2, SLC6A3

Molecular functions related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD2
2dopamine bindingGO:0352408.8SLC6A3, DRD2

Products for genes affiliated with Impulse Control Disorder

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Sources for Impulse Control Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet