MCID: IMP006
MIFTS: 43

Impulse Control Disorder malady

Mental diseases category
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Summaries for Impulse Control Disorder

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.

MalaCards: Impulse Control Disorder, also known as impulse control disorders, is related to pathological gambling and parkinson's disease. An important gene associated with Impulse Control Disorder is GRN (granulin), and among its related pathways are Amphetamine addiction and Circadian entrainment. The compounds carbidopa and tyramine have been mentioned in the context of this disorder. Affiliated tissues include brain and testes, and related mouse phenotypes are taste/olfaction and reproductive system.

Wikipedia:65 Impulse control disorder (ICD) is a class of psychiatric disorders characterized by impulsivity ?... more...

Aliases & Classifications for Impulse Control Disorder

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

impulse control disorder 8
impulse control disorders 62


External Ids:

Disease Ontology8 DOID:10937
NCIt40 C34723
ICD9CM27 312.30
MeSH35 D007174

Related Diseases for Impulse Control Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impulse Control Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1pathological gambling30.8DRD2, SLC6A3
2parkinson's disease30.8COMT, DRD2, SLC6A3
3obsessive-compulsive disorder30.4COMT, DRD2, SLC6A3
4drug addiction30.2SLC6A3, DRD2
5social phobia30.2DRD2, COMT
6gilles de la tourette syndrome30.2SLC6A3, DRD2
7bipolar disorder30.1COMT, DRD2, SLC6A3
8kleptomania10.4
9restless legs syndrome10.4
10trichotillomania10.4
11pyromania10.4
12alexithymia10.1
13kluver-bucy syndrome10.1
14prolactinoma10.1
15premature ejaculation10.1
16neurotic excoriation10.1
17intermittent explosive disorder10.1
18bipolar i disorder10.1
19dermatitis10.1
20dystonia10.1
21intellectual disability10.1
22x-linked dystonia-parkinsonism10.1
23oppositional defiant disorder10.1SLC6A3
24nicotine dependence10.0DRD2
25eating disorder10.0COMT, SLC6A3
26memory impairment10.0GRN, SLC6A3
27antisocial personality disorder10.0SLC6A3, DRD2
28striatonigral degeneration10.0SLC6A3, DRD2
29personality disorder10.0DRD2, SLC6A3
30cocaine abuse10.0DRD2, SLC6A3
31drug dependence10.0SLC6A3, DRD2
32cocaine dependence10.0DRD2, SLC6A3
33progressive supranuclear palsy10.0SLC6A3, DRD2
34wilson disease10.0SLC6A3, DRD2
35substance abuse10.0SLC6A3, DRD2
36kidney rhabdoid cancer10.0GRN, COMT
37movement disease10.0SLC6A3, DRD2
38schizoaffective disorder10.0COMT, DRD2
39narcolepsy10.0DRD2, COMT
40multiple system atrophy10.0SLC6A3, DRD2
41dementia10.0COMT, GRN, SLC6A3
42amyotrophic lateral sclerosis10.0SLC6A3, GRN
43huntington's disease10.0DRD2, SLC6A3
44mental retardation10.0DRD2, COMT
45substance dependence10.0SLC6A3, DRD2, COMT
46conduct disorder10.0COMT, DRD2, SLC6A3
47alcohol abuse9.9SLC6A3, DRD2, COMT
48anxiety disorder9.9SLC6A3, DRD2, COMT
49attention deficit hyperactivity disorder9.9SLC6A3, DRD2, COMT
50psychotic disorder9.9SLC6A3, DRD2, COMT

Graphical network of the top 20 diseases related to Impulse Control Disorder:



Diseases related to impulse control disorder

Symptoms for Impulse Control Disorder

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Drugs & Therapeutics for Impulse Control Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Impulse Control Disorder

Search NIH Clinical Center for Impulse Control Disorder

Genetic Tests for Impulse Control Disorder

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Anatomical Context for Impulse Control Disorder

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33MalaCards
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MalaCards organs/tissues related to Impulse Control Disorder:

33
Brain, Testes

Animal Models for Impulse Control Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Impulse Control Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1SLC6A3, DRD2
2MP:00053898.1SLC6A3, GRN, DRD2, COMT
3MP:00053868.0COMT, DRD2, GRN, SLC6A3
4MP:00036317.9GRN, COMT, DRD2, SLC6A3
5MP:00053767.7COMT, SLC6A3, GRN, DRD2

Publications for Impulse Control Disorder

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52PubMed
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Articles related to Impulse Control Disorder:

(show all 34)
idTitleAuthorsYear
1
Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study. (24434037)
2014
2
Depression and impulse control disorders in Parkinson's disease: Two sides of the same coin? (24239733)
2014
3
Major depression after withdrawing dopamine agonists in two patients with restless legs syndrome and impulse control disorders. (23714418)
2013
4
Three cases of impulse control disorder in Parkinson's disease patients receiving dopamine replacement therapy. (23472375)
2013
5
Impulse control disorder in a patient on long-term treatment with bromocriptine for a macroprolactinoma. (24045609)
2013
6
The role of self-awareness and cognitive dysfunction in Parkinson's disease with and without impulse-control disorder. (23686032)
2013
7
Dopamine agonist-induced impulse control disorders in a patient with prolactinoma. (23261076)
2013
8
Impulse control disorder in a patient with X-linked dystonia-parkinsonism after bilateral pallidal deep brain stimulation. (23920134)
2013
9
Pathological generosity: An atypical impulse control disorder after a left subcortical stroke. (23962063)
2013
10
Transdermal rotigotine causes impulse control disorders in patients with restless legs syndrome. (22030321)
2012
11
Is premature ejaculation an impulse control disorder? (22543077)
2012
12
Comorbid impulse control disorder in bipolar disorder: the role of antidepressants. (22423377)
2012
13
Alexithymia is associated with impulsivity in newly-diagnosed, drug-naA^ve patients with Parkinson's disease: an affective risk factor for the development of impulse-control disorders? (23224478)
2012
14
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders. (22113132)
2012
15
Impulse-control disorders in gilles de la tourette syndrome. (22450610)
2012
16
Prevalence and pharmacological factors associated with impulse-control disorder symptoms in patients with Parkinson disease. (23123689)
2012
17
Zoophilia and impulse control disorder in a patient with Parkinson disease. (22057400)
2012
18
Impulse control disorder comorbidity among patients with bipolar I disorder. (21683175)
2011
19
The emergence of devastating impulse control disorders during dopamine agonist therapy of the restless legs syndrome. (21412200)
2011
20
Obsessive-compulsive disorder, impulse control disorders and drug addiction: common features and potential treatments. (21568361)
2011
21
Dermatitis artefacta in a patient affected by impulse control disorder: case report. (21489363)
2011
22
Tourette's disease with impulse control disorder. (21431012)
2011
23
Pathological gambling: an impulse control disorder? Measurement of impulsivity using neurocognitive tests. (20803888)
2010
24
Swallowing foreign bodies as an example of impulse control disorder in a patient with intellectual disabilities: a case report. (20941350)
2010
25
Kleptomania, an unusual impulsive control disorder in Parkinson's disease? (20202886)
2010
26
Impulse control disorder and piribedil: report of 5 cases. (19959959)
2010
27
Parkinsonism and impulse control disorder: presentation of a new progranulin gene mutation. (19133655)
2009
28
Impulse control disorders and pathological gambling in patients with Parkinson disease. (18332838)
2008
29
Kleptomania in impulse control disorders, obsessive-compulsive disorder, and bipolar spectrum disorder: clinical and therapeutic implications. (12686000)
2003
30
Tiagabine in the Management of Postencephalitic Epilepsy and Impulse Control Disorder. (12609422)
2002
31
Social phobia as a comorbid condition in sex offenders with paraphilia or impulse control disorder. (11504324)
2001
32
Internet addiction associated with features of impulse control disorder: is it a real psychiatric disorder? (11686127)
2001
33
Conceptual issues in trichotillomania, a prototypical impulse control disorder. (11122936)
2000
34
Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. (10823300)
2000

Variations for Impulse Control Disorder

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Expression for genes affiliated with Impulse Control Disorder

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impulse Control Disorder

Search GEO for disease gene expression data for Impulse Control Disorder.

Pathways for genes affiliated with Impulse Control Disorder

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50PathCards, 30KEGG
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Pathways related to Impulse Control Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1SLC6A3, DRD2
2
Show member pathways
8.5SLC6A3, DRD2, COMT

Compounds for genes affiliated with Impulse Control Disorder

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1carbidopa45 2910.7SLC6A3, COMT
2tyramine45 29 2411.6SLC6A3, COMT
3fluvoxamine45 51 1111.6SLC6A3, COMT
4venlafaxine45 51 24 1112.6COMT, SLC6A3
5selegiline45 1110.6SLC6A3, COMT
6ibzm459.6SLC6A3, DRD2
7alpha-methyl-p-tyrosine459.5SLC6A3, DRD2
8tetrabenazine45 29 61 51 1113.5SLC6A3, DRD2
9d amphetamine459.5SLC6A3, DRD2
10raclopride45 2910.5SLC6A3, DRD2
11piperazine45 1110.5DRD2, SLC6A3
12trimipramine45 51 1111.5DRD2, SLC6A3
13sulpiride45 29 1111.5DRD2, SLC6A3
14paroxetine45 51 29 1112.5SLC6A3, COMT
15reserpine45 29 1111.5SLC6A3, DRD2
16phencyclidine45 29 1111.4DRD2, SLC6A3
17quinpirole45 2910.4DRD2, SLC6A3
18amantadine45 1110.4DRD2, COMT
19antipsychotics519.4COMT, DRD2
20ropinirole45 1110.4DRD2, COMT
21pergolide45 29 1111.4DRD2, COMT
22ketamine45 29 1111.3SLC6A3, DRD2
23cabergoline45 29 1111.3DRD2, COMT
24spec-t459.2SLC6A3, DRD2
25quetiapine45 51 29 24 1113.2SLC6A3, DRD2
26fluoxetine45 51 29 1112.1DRD2, SLC6A3
27amphetamine45 51 1111.0DRD2, SLC6A3
28methylphenidate45 51 1111.0SLC6A3, DRD2, COMT
29maoa459.0SLC6A3, DRD2, COMT
30pramipexole45 29 51 1112.0COMT, DRD2, SLC6A3
31heroin45 51 1111.0SLC6A3, DRD2, COMT
32bupropion51 45 24 1112.0SLC6A3, DRD2, COMT
33apomorphine29 45 1110.9COMT, DRD2, SLC6A3
34bromocriptine45 29 1110.9SLC6A3, DRD2, COMT
35methamphetamine45 51 1110.9SLC6A3, DRD2, COMT
36risperidone45 51 29 61 24 1113.9COMT, DRD2, SLC6A3
376-hydroxydopamine458.9SLC6A3, DRD2, COMT
38mptp458.9COMT, DRD2, SLC6A3
39olanzapine45 51 29 24 1112.9SLC6A3, DRD2, COMT
40levodopa45 119.9COMT, DRD2, SLC6A3
41clozapine45 29 51 1111.9SLC6A3, DRD2, COMT
42morphine45 51 29 1111.9COMT, DRD2, SLC6A3
43cocaine45 119.9COMT, DRD2, SLC6A3
445-hydroxytryptamine458.9SLC6A3, DRD2, COMT
45nicotine45 29 51 1111.9COMT, DRD2, SLC6A3
46nmda45 299.8COMT, DRD2, SLC6A3
47opiate458.8SLC6A3, DRD2
48norepinephrine45 24 1110.8SLC6A3, DRD2, COMT
49dopamine45 29 24 1111.7COMT, DRD2, SLC6A3
50glutamate458.5SLC6A3, DRD2, COMT

GO Terms for genes affiliated with Impulse Control Disorder

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16Gene Ontology
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Cellular components related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1SLC6A3, DRD2

Biological processes related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.6SLC6A3, COMT
2neurotransmitter biosynthetic processGO:0421369.5SLC6A3, COMT
3cell deathGO:0082199.4SLC6A3, GRN
4adenohypophysis developmentGO:0219849.4SLC6A3, DRD2
5response to iron ionGO:0100399.4DRD2, SLC6A3
6prepulse inhibitionGO:0601349.3SLC6A3, DRD2
7response to cocaineGO:0422209.2SLC6A3, DRD2
8response to nicotineGO:0350949.2SLC6A3, DRD2
9positive regulation of multicellular organism growthGO:0400189.1DRD2, SLC6A3
10sensory perception of smellGO:0076089.0SLC6A3, DRD2
11locomotory behaviorGO:0076268.8SLC6A3, DRD2
12response to drugGO:0424938.7COMT, DRD2, SLC6A3

Molecular functions related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD2
2dopamine bindingGO:0352408.8SLC6A3, DRD2

Products for genes affiliated with Impulse Control Disorder

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Impulse Control Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet