MCID: IMP006
MIFTS: 41

Impulse Control Disorder malady

Summaries for Impulse Control Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.

MalaCards: Impulse Control Disorder, also known as impulse control disorders, is related to parkinson's disease and pathological gambling. An important gene associated with Impulse Control Disorder is GRN (granulin), and among its related pathways are Amphetamine addiction and Circadian entrainment. The compounds carbidopa and nmda have been mentioned in the context of this disorder. Affiliated tissues include testes and brain, and related mouse phenotypes are taste/olfaction and reproductive system.

Wikipedia:63 Impulse control disorder (ICD) is a class of psychiatric disorders characterized by impulsivity –... more...

Aliases & Classifications for Impulse Control Disorder

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

impulse control disorder 8
impulse control disorders 60


External Ids:

Disease Ontology8 DOID:10937
NCIt39 C34723
ICD9CM27 312.30
MeSH34 D007174

Related Diseases for Impulse Control Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Impulse Control Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.7SLC6A3, COMT, DRD2
2pathological gambling30.7SLC6A3, DRD2
3restless legs syndrome30.5DRD2
4bipolar disorder30.4SLC6A3, DRD2, COMT
5obsessive-compulsive disorder30.3DRD2, SLC6A3, COMT
6gilles de la tourette syndrome30.1DRD2, SLC6A3
7social phobia30.1COMT, DRD2
8trichotillomania10.4
9kleptomania10.4
10pyromania10.3
11prolactinoma10.1
12major depressive disorder10.1
13alexithymia10.1
14kluver-bucy syndrome10.1
15intermittent explosive disorder10.1
16bipolar i disorder10.1
17premature ejaculation10.1
18dermatitis10.1
19intellectual disability10.1
20paraphilia disorder10.1
21withdrawal disorder10.1
22bulimia nervosa10.0COMT
23lewy body dementia10.0SLC6A3
24essential tremor10.0SLC6A3
25anorexia nervosa10.0COMT
26apraxia10.0GRN
27heroin dependence10.0DRD2
28nicotine dependence10.0DRD2
29fibromyalgia10.0COMT
30alcohol dependence10.0DRD2
31panic disorder10.0COMT
32amyotrophic lateral sclerosis10.0GRN, SLC6A3
33hepatitis10.0COMT
34memory impairment10.0SLC6A3, GRN
35eating disorder10.0COMT, SLC6A3
36kidney rhabdoid cancer10.0GRN, COMT
37antisocial personality disorder10.0SLC6A3, DRD2
38cocaine dependence10.0DRD2, SLC6A3
39substance abuse10.0DRD2, SLC6A3
40striatonigral degeneration10.0SLC6A3, DRD2
41personality disorder10.0SLC6A3, DRD2
42drug addiction10.0SLC6A3, DRD2
43progressive supranuclear palsy10.0SLC6A3, DRD2
44movement disease10.0SLC6A3, DRD2
45cocaine abuse10.0DRD2, SLC6A3
46drug dependence10.0SLC6A3, DRD2
47wilson disease10.0SLC6A3, DRD2
48huntington's disease10.0DRD2, SLC6A3
49dementia10.0GRN, SLC6A3, COMT
50multiple system atrophy10.0DRD2, SLC6A3

Graphical network of the top 20 diseases related to Impulse Control Disorder:



Diseases related to impulse control disorder

Clinical Features for Impulse Control Disorder

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Drugs & Therapeutics for Impulse Control Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Impulse Control Disorder

Drug clinical trials:

Search ClinicalTrials for Impulse Control Disorder

Search NIH Clinical Center for Impulse Control Disorder

Search CenterWatch for Impulse Control Disorder

Genetic Tests for Impulse Control Disorder

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Anatomical Context for Impulse Control Disorder

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32MalaCards
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MalaCards organs/tissues related to Impulse Control Disorder:

32
Testes, Brain

Animal Models for Impulse Control Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Impulse Control Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.8SLC6A3, DRD2
2MP:00053898.1SLC6A3, GRN, DRD2, COMT
3MP:00053868.0SLC6A3, COMT, DRD2, GRN
4MP:00053768.0COMT, DRD2, SLC6A3, GRN
5MP:00036317.9GRN, SLC6A3, COMT, DRD2

Publications for Impulse Control Disorder

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50PubMed
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Articles related to Impulse Control Disorder:

(show all 44)
idTitleAuthorsYear
1
Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study. (24434037)
2014
2
Depression and impulse control disorders in Parkinson's disease: Two sides of the same coin? (24239733)
2014
3
Major depression after withdrawing dopamine agonists in two patients with restless legs syndrome and impulse control disorders. (23714418)
2013
4
Three cases of impulse control disorder in Parkinson's disease patients receiving dopamine replacement therapy. (23472375)
2013
5
Impulse control disorder in a patient on long-term treatment with bromocriptine for a macroprolactinoma. (24045609)
2013
6
The role of self-awareness and cognitive dysfunction in Parkinson's disease with and without impulse-control disorder. (23686032)
2013
7
Impulsivity in borderline personality disorder: a matter of disturbed impulse control or a facet of emotional dysregulation? (23424747)
2013
8
Dopamine agonist-induced impulse control disorders in a patient with prolactinoma. (23261076)
2013
9
Impulse control disorder in a patient with X-linked dystonia-parkinsonism after bilateral pallidal deep brain stimulation. (23920134)
2013
10
Pathological generosity: An atypical impulse control disorder after a left subcortical stroke. (23962063)
2013
11
Transdermal rotigotine causes impulse control disorders in patients with restless legs syndrome. (22030321)
2012
12
Is premature ejaculation an impulse control disorder? (22543077)
2012
13
Comorbid impulse control disorder in bipolar disorder: the role of antidepressants. (22423377)
2012
14
Alexithymia is associated with impulsivity in newly-diagnosed, drug-naA^ve patients with Parkinson's disease: an affective risk factor for the development of impulse-control disorders? (23224478)
2012
15
Differential relationships of impulsivity or antisocial symptoms on P50, N100, orA P200 auditory sensory gating in controls and antisocial personality disorder. (22464943)
2012
16
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders. (22113132)
2012
17
Impulse-control disorders in gilles de la tourette syndrome. (22450610)
2012
18
Prevalence and pharmacological factors associated with impulse-control disorder symptoms in patients with Parkinson disease. (23123689)
2012
19
Zoophilia and impulse control disorder in a patient with Parkinson disease. (22057400)
2012
20
Self-report and laboratory measures of impulsivity in patients with schizophrenia or schizoaffective disorder and healthy controls. (21106252)
2011
21
Impulse control disorder comorbidity among patients with bipolar I disorder. (21683175)
2011
22
The emergence of devastating impulse control disorders during dopamine agonist therapy of the restless legs syndrome. (21412200)
2011
23
Obsessive-compulsive disorder, impulse control disorders and drug addiction: common features and potential treatments. (21568361)
2011
24
Association analyses of MAOA in Chinese Han subjects with attention-deficit/hyperactivity disorder: family-based association test, case-control study, and quantitative traits of impulsivity. (21761555)
2011
25
Dermatitis artefacta in a patient affected by impulse control disorder: case report. (21489363)
2011
26
Tourette's disease with impulse control disorder. (21431012)
2011
27
DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. (20736997)
2010
28
Pathological gambling: an impulse control disorder? Measurement of impulsivity using neurocognitive tests. (20803888)
2010
29
Swallowing foreign bodies as an example of impulse control disorder in a patient with intellectual disabilities: a case report. (20941350)
2010
30
Kleptomania, an unusual impulsive control disorder in Parkinson's disease? (20202886)
2010
31
Impulse control disorder and piribedil: report of 5 cases. (19959959)
2010
32
Parkinsonism and impulse control disorder: presentation of a new progranulin gene mutation. (19133655)
2009
33
Impulse control disorder behaviors associated with pramipexole used to treat fibromyalgia. (19241148)
2009
34
Impulse control disorders and pathological gambling in patients with Parkinson disease. (18332838)
2008
35
Attention and impulse control in children with borderline intelligence with or without conduct disorder. (19235399)
2008
36
The dopamine transporter gene and the impulsivity phenotype in attention deficit hyperactivity disorder: a case-control association study in a Korean sample. (16368111)
2006
37
Comorbidity on disorders with loss of impulse-control: pathological gambling, addictions and personality disorders. (16552635)
2006
38
Kleptomania in impulse control disorders, obsessive-compulsive disorder, and bipolar spectrum disorder: clinical and therapeutic implications. (12686000)
2003
39
Tiagabine in the Management of Postencephalitic Epilepsy and Impulse Control Disorder. (12609422)
2002
40
Impulsive personality traits in male pedophiles versus healthy controls: is pedophilia an impulsive-aggressive disorder? (11893991)
2002
41
Social phobia as a comorbid condition in sex offenders with paraphilia or impulse control disorder. (11504324)
2001
42
Internet addiction associated with features of impulse control disorder: is it a real psychiatric disorder? (11686127)
2001
43
Conceptual issues in trichotillomania, a prototypical impulse control disorder. (11122936)
2000
44
Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. (10823300)
2000

Genetic Variations for Impulse Control Disorder

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Expression for genes affiliated with Impulse Control Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impulse Control Disorder

Search GEO for disease gene expression data for Impulse Control Disorder.

Pathways for genes affiliated with Impulse Control Disorder

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29KEGG
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Pathways related to Impulse Control Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1SLC6A3, DRD2
2
Hide members
8.5SLC6A3, DRD2, COMT

Compounds for genes affiliated with Impulse Control Disorder

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1carbidopa44 2810.7SLC6A3, COMT
2nmda44 2810.7SLC6A3, COMT
3tyramine44 28 2411.6SLC6A3, COMT
4selegiline44 1110.6SLC6A3, COMT
5paroxetine44 49 28 1112.6COMT, SLC6A3
6ibzm449.6SLC6A3, DRD2
7alpha-methyl-p-tyrosine449.5SLC6A3, DRD2
8tetrabenazine44 28 59 49 1113.5SLC6A3, DRD2
9d amphetamine449.5SLC6A3, DRD2
10raclopride44 2810.5SLC6A3, DRD2
11piperazine44 1110.5SLC6A3, DRD2
12sulpiride44 28 1111.5SLC6A3, DRD2
13trimipramine49 44 1111.5SLC6A3, DRD2
14reserpine44 28 1111.5DRD2, SLC6A3
15phencyclidine44 28 1111.4DRD2, SLC6A3
16quinpirole44 2810.4DRD2, SLC6A3
17antipsychotics499.4DRD2, COMT
18amantadine44 1110.4COMT, DRD2
19ketamine44 28 1111.4SLC6A3, DRD2
20ropinirole44 1110.4DRD2, COMT
21pergolide28 44 1111.4DRD2, COMT
22spec-t449.3SLC6A3, DRD2
23cabergoline28 44 1111.3DRD2, COMT
24quetiapine44 49 28 11 2413.3DRD2, SLC6A3
25fluoxetine49 44 28 1112.2SLC6A3, DRD2
26amphetamine44 1110.2SLC6A3, DRD2
27opiate449.1SLC6A3, DRD2
28haloperidol44 28 2 49 1113.0DRD2, SLC6A3
29methylphenidate44 49 1111.0SLC6A3, DRD2, COMT
30maoa449.0SLC6A3, DRD2, COMT
31pramipexole44 49 28 1112.0COMT, DRD2, SLC6A3
32heroin44 49 1111.0SLC6A3, DRD2, COMT
33bupropion44 49 11 2412.0SLC6A3, DRD2, COMT
34apomorphine44 28 1110.9COMT, DRD2, SLC6A3
35risperidone28 44 49 59 11 2413.9SLC6A3, DRD2, COMT
36bromocriptine28 44 1110.9SLC6A3, DRD2, COMT
37methamphetamine44 49 1110.9COMT, DRD2, SLC6A3
386-hydroxydopamine448.9SLC6A3, DRD2, COMT
39mptp448.9COMT, DRD2, SLC6A3
40olanzapine49 44 28 11 2412.9SLC6A3, DRD2, COMT
41levodopa44 119.9COMT, DRD2, SLC6A3
42clozapine44 28 49 1111.9SLC6A3, DRD2, COMT
43morphine44 49 28 1111.9COMT, DRD2, SLC6A3
44cocaine44 119.9SLC6A3, DRD2, COMT
455-hydroxytryptamine448.9COMT, DRD2, SLC6A3
46nicotine44 49 28 1111.9COMT, DRD2, SLC6A3
47cysteine448.8SLC6A3, GRN, COMT
48norepinephrine44 11 2410.8COMT, DRD2, SLC6A3
49dopamine44 28 11 2411.7SLC6A3, DRD2, COMT
50glutamate448.2SLC6A3, DRD2, COMT

GO Terms for genes affiliated with Impulse Control Disorder

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16Gene Ontology
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Cellular components related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1SLC6A3, DRD2

Biological processes related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.6SLC6A3, COMT
2neurotransmitter biosynthetic processGO:0421369.5COMT, SLC6A3
3cell deathGO:0082199.4GRN, SLC6A3
4adenohypophysis developmentGO:0219849.4SLC6A3, DRD2
5response to iron ionGO:0100399.4DRD2, SLC6A3
6prepulse inhibitionGO:0601349.3DRD2, SLC6A3
7response to cocaineGO:0422209.2DRD2, SLC6A3
8response to nicotineGO:0350949.2DRD2, SLC6A3
9positive regulation of multicellular organism growthGO:0400189.1DRD2, SLC6A3
10sensory perception of smellGO:0076089.0DRD2, SLC6A3
11locomotory behaviorGO:0076268.8DRD2, SLC6A3
12response to drugGO:0424938.7SLC6A3, COMT, DRD2

Molecular functions related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD2
2dopamine bindingGO:0352408.8SLC6A3, DRD2

Products for genes affiliated with Impulse Control Disorder

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  • Antibodies
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Sources for Impulse Control Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet