MCID: IMP006
MIFTS: 37

Impulse Control Disorder malady

Summaries for Impulse Control Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.

MalaCards: Impulse Control Disorder, also known as impulse control disorders, is related to pathological gambling and parkinson's disease. An important gene associated with Impulse Control Disorder is GRN (granulin), and among its related pathways are Amphetamine addiction and Circadian entrainment. The compounds carbidopa and nmda have been mentioned in the context of this disorder. Related mouse phenotypes are taste/olfaction and reproductive system.

Wikipedia:64 Impulse control disorder (ICD) is a class of psychiatric disorders characterized by impulsivity –... more...

Aliases & Classifications for Impulse Control Disorder

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

impulse control disorder 8
impulse control disorders 61


External Ids:

Disease Ontology8 DOID:10937
NCIt40 C34723
ICD9CM27 312.30
MeSH35 D007174

Related Diseases for Impulse Control Disorder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Impulse Control Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1pathological gambling30.7SLC6A3, DRD2
2parkinson's disease30.6SLC6A3, DRD2, COMT
3restless legs syndrome30.5DRD2
4bipolar disorder30.5COMT, DRD2, SLC6A3
5obsessive-compulsive disorder30.4COMT, DRD2, SLC6A3
6fibromyalgia30.2COMT
7drug addiction30.1DRD2, SLC6A3
8social phobia30.1COMT, DRD2
9trichotillomania10.4
10kleptomania10.4
11pyromania10.4
12bipolar i disorder10.4
13prolactinoma10.1
14neurotic excoriation10.1
15alexithymia10.1
16kluver-bucy syndrome10.1
17intermittent explosive disorder10.1
18premature ejaculation10.1
19bulimia nervosa10.0COMT
20lewy body dementia10.0SLC6A3
21essential tremor10.0SLC6A3
22anorexia nervosa10.0COMT
23apraxia10.0GRN
24heroin dependence10.0DRD2
25nicotine dependence10.0DRD2
26alcohol dependence10.0DRD2
27panic disorder10.0COMT
28amyotrophic lateral sclerosis10.0SLC6A3, GRN
29hepatitis10.0COMT
30memory impairment10.0GRN, SLC6A3
31eating disorder10.0COMT, SLC6A3
32kidney rhabdoid cancer10.0GRN, COMT
33antisocial personality disorder10.0SLC6A3, DRD2
34gilles de la tourette syndrome10.0SLC6A3, DRD2
35cocaine dependence10.0DRD2, SLC6A3
36substance abuse10.0SLC6A3, DRD2
37striatonigral degeneration10.0SLC6A3, DRD2
38personality disorder10.0SLC6A3, DRD2
39progressive supranuclear palsy10.0SLC6A3, DRD2
40movement disease10.0SLC6A3, DRD2
41cocaine abuse10.0SLC6A3, DRD2
42drug dependence10.0SLC6A3, DRD2
43wilson disease10.0DRD2, SLC6A3
44huntington's disease10.0SLC6A3, DRD2
45dementia10.0SLC6A3, GRN, COMT
46multiple system atrophy10.0DRD2, SLC6A3
47schizoaffective disorder10.0DRD2, COMT
48multiple sclerosis10.0COMT, DRD2
49anxiety disorder10.0SLC6A3, DRD2, COMT
50substance dependence10.0SLC6A3, DRD2, COMT

Graphical network of the top 20 diseases related to Impulse Control Disorder:



Diseases related to impulse control disorder

Clinical Features for Impulse Control Disorder

Drugs & Therapeutics for Impulse Control Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Impulse Control Disorder

Drug clinical trials:

Search ClinicalTrials for Impulse Control Disorder

Search NIH Clinical Center for Impulse Control Disorder

Search CenterWatch for Impulse Control Disorder

Genetic Tests for Impulse Control Disorder

Anatomical Context for Impulse Control Disorder

Animal Models for Impulse Control Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Impulse Control Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.8SLC6A3, DRD2
2MP:00053898.1SLC6A3, GRN, DRD2, COMT
3MP:00053868.0COMT, DRD2, GRN, SLC6A3
4MP:00053768.0SLC6A3, GRN, DRD2, COMT
5MP:00036317.9COMT, DRD2, GRN, SLC6A3

Publications for Impulse Control Disorder

Sources:
51PubMed
See all sources

Articles related to Impulse Control Disorder:

(show all 37)
idTitleAuthorsYear
1
Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study. (24434037)
2014
2
Depression and impulse control disorders in Parkinson's disease: Two sides of the same coin? (24239733)
2014
3
Major depression after withdrawing dopamine agonists in two patients with restless legs syndrome and impulse control disorders. (23714418)
2013
4
Three cases of impulse control disorder in Parkinson's disease patients receiving dopamine replacement therapy. (23472375)
2013
5
Impulse control disorder in a patient on long-term treatment with bromocriptine for a macroprolactinoma. (24045609)
2013
6
The role of self-awareness and cognitive dysfunction in Parkinson's disease with and without impulse-control disorder. (23686032)
2013
7
Impulsivity in borderline personality disorder: a matter of disturbed impulse control or a facet of emotional dysregulation? (23424747)
2013
8
Dopamine agonist-induced impulse control disorders in a patient with prolactinoma. (23261076)
2013
9
Impulse control disorder in a patient with X-linked dystonia-parkinsonism after bilateral pallidal deep brain stimulation. (23920134)
2013
10
Pathological generosity: An atypical impulse control disorder after a left subcortical stroke. (23962063)
2013
11
Transdermal rotigotine causes impulse control disorders in patients with restless legs syndrome. (22030321)
2012
12
Is premature ejaculation an impulse control disorder? (22543077)
2012
13
Comorbid impulse control disorder in bipolar disorder: the role of antidepressants. (22423377)
2012
14
Alexithymia is associated with impulsivity in newly-diagnosed, drug-naA^ve patients with Parkinson's disease: an affective risk factor for the development of impulse-control disorders? (23224478)
2012
15
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders. (22113132)
2012
16
Impulse-control disorders in gilles de la tourette syndrome. (22450610)
2012
17
Prevalence and pharmacological factors associated with impulse-control disorder symptoms in patients with Parkinson disease. (23123689)
2012
18
Zoophilia and impulse control disorder in a patient with Parkinson disease. (22057400)
2012
19
Impulse control disorder comorbidity among patients with bipolar I disorder. (21683175)
2011
20
The emergence of devastating impulse control disorders during dopamine agonist therapy of the restless legs syndrome. (21412200)
2011
21
Obsessive-compulsive disorder, impulse control disorders and drug addiction: common features and potential treatments. (21568361)
2011
22
Dermatitis artefacta in a patient affected by impulse control disorder: case report. (21489363)
2011
23
Tourette's disease with impulse control disorder. (21431012)
2011
24
Pathological gambling: an impulse control disorder? Measurement of impulsivity using neurocognitive tests. (20803888)
2010
25
Swallowing foreign bodies as an example of impulse control disorder in a patient with intellectual disabilities: a case report. (20941350)
2010
26
Impulse control disorder and piribedil: report of 5 cases. (19959959)
2010
27
Parkinsonism and impulse control disorder: presentation of a new progranulin gene mutation. (19133655)
2009
28
Impulse control disorder behaviors associated with pramipexole used to treat fibromyalgia. (19241148)
2009
29
Impulse control disorders and pathological gambling in patients with Parkinson disease. (18332838)
2008
30
Attention and impulse control in children with borderline intelligence with or without conduct disorder. (19235399)
2008
31
Comorbidity on disorders with loss of impulse-control: pathological gambling, addictions and personality disorders. (16552635)
2006
32
Kleptomania in impulse control disorders, obsessive-compulsive disorder, and bipolar spectrum disorder: clinical and therapeutic implications. (12686000)
2003
33
Tiagabine in the Management of Postencephalitic Epilepsy and Impulse Control Disorder. (12609422)
2002
34
Social phobia as a comorbid condition in sex offenders with paraphilia or impulse control disorder. (11504324)
2001
35
Internet addiction associated with features of impulse control disorder: is it a real psychiatric disorder? (11686127)
2001
36
Conceptual issues in trichotillomania, a prototypical impulse control disorder. (11122936)
2000
37
Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. (10823300)
2000

Genetic Variations for Impulse Control Disorder

Expression for genes affiliated with Impulse Control Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Impulse Control Disorder

Search GEO for disease gene expression data for Impulse Control Disorder.

Pathways for genes affiliated with Impulse Control Disorder

Sources:
30KEGG
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Pathways related to Impulse Control Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1SLC6A3, DRD2
2
Hide members
8.5SLC6A3, DRD2, COMT

Compounds for genes affiliated with Impulse Control Disorder

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1carbidopa45 2910.7SLC6A3, COMT
2nmda45 2910.7SLC6A3, COMT
3tyramine45 29 2411.6SLC6A3, COMT
4selegiline45 1110.6SLC6A3, COMT
5paroxetine45 50 29 1112.6COMT, SLC6A3
6ibzm459.6SLC6A3, DRD2
7alpha-methyl-p-tyrosine459.5SLC6A3, DRD2
8tetrabenazine45 29 60 50 1113.5SLC6A3, DRD2
9d amphetamine459.5SLC6A3, DRD2
10raclopride45 2910.5SLC6A3, DRD2
11piperazine45 1110.5SLC6A3, DRD2
12sulpiride45 29 1111.5SLC6A3, DRD2
13trimipramine50 45 1111.5SLC6A3, DRD2
14reserpine45 29 1111.5DRD2, SLC6A3
15phencyclidine45 29 1111.4DRD2, SLC6A3
16quinpirole45 2910.4DRD2, SLC6A3
17antipsychotics509.4DRD2, COMT
18amantadine45 1110.4COMT, DRD2
19ketamine45 29 1111.4SLC6A3, DRD2
20ropinirole45 1110.4DRD2, COMT
21pergolide29 45 1111.4DRD2, COMT
22spec-t459.3SLC6A3, DRD2
23cabergoline29 45 1111.3DRD2, COMT
24quetiapine45 50 29 11 2413.3DRD2, SLC6A3
25fluoxetine50 45 29 1112.2SLC6A3, DRD2
26amphetamine45 1110.2SLC6A3, DRD2
27opiate459.1SLC6A3, DRD2
28haloperidol45 29 2 50 1113.0DRD2, SLC6A3
29methylphenidate45 50 1111.0SLC6A3, DRD2, COMT
30maoa459.0SLC6A3, DRD2, COMT
31pramipexole45 50 29 1112.0COMT, DRD2, SLC6A3
32heroin45 50 1111.0SLC6A3, DRD2, COMT
33bupropion45 50 11 2412.0SLC6A3, DRD2, COMT
34apomorphine45 29 1110.9COMT, DRD2, SLC6A3
35risperidone29 45 50 60 11 2413.9SLC6A3, DRD2, COMT
36bromocriptine29 45 1110.9SLC6A3, DRD2, COMT
37methamphetamine45 50 1110.9COMT, DRD2, SLC6A3
386-hydroxydopamine458.9SLC6A3, DRD2, COMT
39mptp458.9COMT, DRD2, SLC6A3
40olanzapine50 45 29 11 2412.9SLC6A3, DRD2, COMT
41levodopa45 119.9COMT, DRD2, SLC6A3
42clozapine45 29 50 1111.9SLC6A3, DRD2, COMT
43morphine45 50 29 1111.9COMT, DRD2, SLC6A3
44cocaine45 119.9SLC6A3, DRD2, COMT
455-hydroxytryptamine458.9COMT, DRD2, SLC6A3
46nicotine45 50 29 1111.9COMT, DRD2, SLC6A3
47cysteine458.8SLC6A3, GRN, COMT
48norepinephrine45 11 2410.8COMT, DRD2, SLC6A3
49dopamine45 29 11 2411.7SLC6A3, DRD2, COMT
50glutamate458.2SLC6A3, DRD2, COMT

GO Terms for genes affiliated with Impulse Control Disorder

Sources:
16Gene Ontology
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Cellular components related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1SLC6A3, DRD2

Biological processes related to Impulse Control Disorder according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:0424209.6SLC6A3, COMT
2neurotransmitter biosynthetic processGO:0421369.5SLC6A3, COMT
3cell deathGO:0082199.4SLC6A3, GRN
4adenohypophysis developmentGO:0219849.4SLC6A3, DRD2
5response to iron ionGO:0100399.4DRD2, SLC6A3
6prepulse inhibitionGO:0601349.3SLC6A3, DRD2
7response to cocaineGO:0422209.2SLC6A3, DRD2
8response to nicotineGO:0350949.2SLC6A3, DRD2
9positive regulation of multicellular organism growthGO:0400189.1DRD2, SLC6A3
10sensory perception of smellGO:0076089.0SLC6A3, DRD2
11locomotory behaviorGO:0076268.8SLC6A3, DRD2
12response to drugGO:0424938.7COMT, DRD2, SLC6A3

Molecular functions related to Impulse Control Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD2
2dopamine bindingGO:0352408.8SLC6A3, DRD2

Products for genes affiliated with Impulse Control Disorder

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Sources for Impulse Control Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet