Inclusion Body Myositis malady
Categories: Genetic diseases, Rare diseases, Neuronal diseases, Metabolic diseases, Muscle diseases
11Disease Ontology, 13DISEASES, 24GeneTests, 25Genetics Home Reference, 26GTR, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 48NINDS, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources
Aliases & Descriptions for Inclusion Body Myositis:
Orphanet epidemiological data:53
inclusion body myositis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: normal life expectancy
Inheritance: Autosomal recessive; Prevalence: 6-9/10000; Age of onset: Adolescent,Adult,Elderly
Global: Genetic diseases, Rare diseases, Metabolic diseases
Anatomical: Neuronal diseases, Muscle diseases
ICD10: 30 29
NIH Rare Diseases:47 Inclusion body myositis (IBM) is an inflammatory myopathy that is characterized by chronic, progressive muscle inflammation and muscle weakness. Symptoms usually begin after the age of 50, although the condition can occur earlier. The onset of muscle weakness usually occurs over months or years. This condition affects both the proximal (close to the trunk of the body) and distal (further away from the trunk) muscles. There is currently no effective treatment for IBM. The cause is unclear in most cases, but it can sometimes be inherited. Last updated: 9/26/2014
MalaCards based summary: Inclusion Body Myositis, also known as nonaka myopathy, is related to inclusion body myopathy, autosomal recessive and hereditary inclusion body myopathy type 4, and has symptoms including autoimmunity, skeletal muscle atrophy and emg abnormality. An important gene associated with Inclusion Body Myositis is GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase), and among its related pathways are Alzheimers Disease Pathway and Neuroscience. The drugs chlorzoxazone and tizanidine hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, t cells and brain, and related mouse phenotypes are immune system and behavior/neurological.
Disease Ontology:11 A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.
Genetics Home Reference:25 Inclusion body myopathy 2 is a condition that primarily affects skeletal muscles, which are muscles that the body uses for movement. This disorder causes muscle weakness that appears in late adolescence or early adulthood and worsens over time.
OMIM:51 Sporadic inclusion body myositis (IBM) is the most common age-related muscle disease in the elderly that results in... (147421) more...
NINDS:48 Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.
Wikipedia:70 Inclusion body myositis (IBM) is an inflammatory muscle disease characterized by slowly progressive... more...
Human phenotypes related to Inclusion Body Myositis:63 53 (show all 15)
UMLS symptoms related to Inclusion Body Myositis:back pain, muscle cramp, muscle rigidity, muscle spasticity, myoclonus, sciatica, torticollis, muscle weakness, myalgia, ophthalmoplegia
Drugs for Inclusion Body Myositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 108)
Interventional clinical trials:(show top 50) (show all 90)
Search NIH Clinical Center for Inclusion Body Myositis
Inferred drug relations via UMLS67/NDF-RT45:
MalaCards organs/tissues related to Inclusion Body Myositis:35
Skeletal muscle, T cells, Brain, Heart, Testes, Eye, Myeloid
Articles related to Inclusion Body Myositis:(show top 50) (show all 594)
Clinvar genetic disease variations for Inclusion Body Myositis:5 (show all 27)
Search GEO for disease gene expression data for Inclusion Body Myositis.
Cellular components related to Inclusion Body Myositis according to GeneCards Suite gene sharing:
Biological processes related to Inclusion Body Myositis according to GeneCards Suite gene sharing:
Molecular functions related to Inclusion Body Myositis according to GeneCards Suite gene sharing:
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet