Inclusion Body Myositis malady

NIH Rare Diseases: Inclusion body myositis (IBM) is an inflammatory myopathy that is characterized by chronic, progressive muscle inflammation and muscle weakness. Symptoms usually begin after the age of 50, although the condition can occur earlier. The onset of muscle weakness usually occurs over months or years. This condition affects both the proximal (close to the trunk of the body) and distal (further away from the trunk) muscles. There is currently no effective treatment for IBM. The cause is unclear in most cases, but it can sometimes be inherited.³⁰

MalaCards: Inclusion Body Myositis, also known as inclusion body myositis (disorder), is related to myofibrillar myopathy and oculopharyngeal muscular dystrophy. An important gene associated with Inclusion Body Myositis is APP (amyloid beta (A4) precursor protein), and among its related pathways are Cell adhesion molecules (CAMs) and Regulation of autophagy. The compounds thioflavin t and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, skeletal muscle and myeloid, and related mouse phenotypes are respiratory system and liver/biliary system.

NINDS: Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.³¹

Wikipedia: Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive...⁴⁴ more...

Aliases & Descriptions:

inclusion body myositis 6 30 31 8 inclusion body myositis (disorder) 6 43 myositis inclusion body 32

inflammatory myopathies 31 inflammatory myopathy 30 ibm 30

Diseases related to inclusion body myositis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 550)

id	Related Disease	Score	Top Affiliating Genes
1	myofibrillar myopathy	32.8	CRYAB, RPS27A, DES
2	oculopharyngeal muscular dystrophy	32.2	MYOD1, BCL2, APP, RPS27A
3	muscular dystrophy	31.8	LMNA, MYOD1, CHKB, LAMA2, MSTN, CAV1
4	alzheimer's disease	30.9	CLU, APOE, APP, MAPT, TTR, PSEN1
5	adult dermatomyositis	30.6	VCAM1, CHKB, ICAM1
6	inclusion body myopathy	30.0	VCP, MME, APP, SNCA, RPS27A, DNAH8
7	tauopathy	29.8	PARK7, PARK2, CDK5, APP, MAPT, SNCA
8	idiopathic myopathy	29.5	VCAM1, CHKB, IFNG, ICAM1, HLA-A, HLA-B
9	myopathy congenital	28.6	CHKB, RPS27A, DNAH8, DES, GAA
10	emery-dreifuss muscular dystrophy	28.4	LMNA, LAMA2, EMD
11	muscular atrophy	28.0	LMNA, BCL2, BCL2L1, CHKB, MSTN, APOE
12	polymyositis	28.0	SERPINA3, VCAM1, CLU, CHKB, LAMA2, CCL21
13	dermatomyositis	27.9	SERPINA3, VCAM1, CHKB, CCL21, CCL19, IFNA1
14	limb-girdle muscular dystrophy	27.9	VCP, LMNA, PARK2, CHKB, LAMA2, EMD
15	homocysteine	25.9	SERPINA3, VCAM1, CLU, LDLR, CD36, APOA1
16	myopathy	24.2	VCAM1, VCP, LMNA, MYOD1, CLU, PARK2
17	cholesterol	23.4	LRP1, SERPINA3, VLDLR, VCAM1, VCP, LMNA
18	myositis	23.1	LRP1, SERPINA3, VLDLR, VCAM1, VCP, LMNA
19	semantic dementia	13.9	APOE, MAPT, RPS27A
20	binswanger's disease	13.8	APOE, APP, MAPT
21	proximal spinal muscular atrophy	13.8	LMNA, CHKB, APOE
22	lattice corneal dystrophy type ii	13.8	GSN, APOE, TTR
23	familial idiopathic basal ganglia calcification	13.7	APP, MAPT, PSEN1
24	primary progressive aphasia	13.7	APP, MAPT, PRNP
25	cognitive disease	13.7	APOE, APP, MAPT
26	basal ganglia calcification	13.7	APP, MAPT, PSEN1
27	hereditary cerebral hemorrhage with amyloidosis	13.7	APP, RPS27A, PSEN1, CST3
28	alzheimer disease type 1	13.7	APOE, APP, MAPT, PSEN1, CST3
29	alzheimer disease type 2	13.7	LRP1, APOE, PSEN1
30	central nervous system disease	13.6	APP, MAPT, CRYAB, TTR, CXCR3
31	allergic contact dermatitis of eyelid	13.6	ICAM1, CXCL11, CXCL9, CXCR3
32	cerebral hemorrhage	13.6	SERPINA3, APOE, APP, RPS27A, PSEN1, CST3
33	scrapie	13.6	CLU, APOE, APP, MAPT, PRNP, CST3
34	amyloid neuropathy	13.6	GSN, APOA1, TTR
35	familial transthyretin amyloidosis	13.6	GSN, APOA1, TTR
36	distal muscular dystrophy	13.5	MAPT, DES, GAA
37	hereditary amyloidosis	13.5	GSN, APOA1, TTR
38	fibrillary astrocytoma	13.5	CHKB, APP, SNCA
39	embryonal sarcoma	13.5	SERPINA3, MYOD1, DES
40	lymphadenitis	13.5	BAX, ICAM1, CXCL9, CXCR3
41	pleomorphic rhabdomyosarcoma	13.4	MYOD1, MME, DES
42	prion disease	13.4	CLU, APP, MAPT, PSEN1, PRNP, CST3
43	early-onset familial alzheimer disease	13.4	APP, MAPT, SNCA, PSEN1
44	parkinson's disease	13.4	PARK7, MAPT, SNCA
45	niemann-pick disease type c1	13.4	APP, MAPT, SNCA
46	cervical dystonia	13.4	APOE, HLA-DQB1, HLA-DRB1
47	alcoholic hepatitis	13.3	APOA1, ICAM1, RPS27A, SQSTM1
48	aphasia	13.3	APOE, APP, MAPT, SNCA, RPS27A, PRNP
49	hyperlipidemia type 3	13.3	LDLR, APOA1, APOE
50	olivopontocerebellar atrophy	13.3	MAPT, SNCA, RPS27A, PRNP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to inclusion body myositis:

²²

MGI Mouse Phenotypes related to inclusion body myositis:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.6	PSEN1, APOE, GSN, CDK5, PARK2, MYOD1
2	liver/biliary system phenotype	MP:0005370	9.0	SQSTM1, DUSP1, IFNG, APOA1, APEX1, CD36
3	other phenotype	MP:0005395	8.9	CXCR3, PRNP, PSEN1, CAV1, MAPT, APP
4	endocrine/exocrine gland phenotype	MP:0005379	8.6	PSEN1, CAV1, IFNG, GSN, LAMA2, LDLR
5	hematopoietic system phenotype	MP:0005397	8.3	DUSP1, DUSP4, DUSP6, HELLS, SQSTM1, GAPDH
6	reproductive system phenotype	MP:0005389	8.2	PRNP, THBS1, SNCA, CAV1, IFNG, APP
7	adipose tissue phenotype	MP:0005375	8.2	APOE, CAV1, DUSP1, CRYAB, HELLS, SQSTM1
8	renal/urinary system phenotype	MP:0005367	8.1	MAPT, CAV1, SNCA, HELLS, THBS1, PSEN1
9	digestive/alimentary phenotype	MP:0005381	7.8	IFNG, CAV1, SNCA, CRYAB, THBS1, APOE
10	skeleton phenotype	MP:0005390	7.5	CAV1, DUSP1, DUSP6, SNCA, CRYAB, HELLS
11	normal phenotype	MP:0002873	7.4	APEX1, APP, MAPT, IFNG, HLA-DQB1, PSEN1
12	integument phenotype	MP:0010771	7.3	IFNG, CAV1, SNCA, HELLS, TGM1, PSEN1
13	vision/eye phenotype	MP:0005391	7.1	MAPT, IFNG, ICAM1, CRYAB, TTR, THBS1
14	immune system phenotype	MP:0005387	6.6	APOA1, APEX1, GSN, MME, CD47, ATG5
15	nervous system phenotype	MP:0003631	6.5	CD47, GSN, APBB1, CAV1, HLA-DQB1, DUSP1
16	behavior/neurological phenotype	MP:0005386	6.2	LMNA, VCP, VLDLR, LRP1, MYLK, MAPT
17	cardiovascular system phenotype	MP:0005385	5.4	DUSP6, DUSP1, HLA-DQB1, CAV1, ICAM1, IFNG
18	growth/size phenotype	MP:0005378	5.3	APEX1, APBB1, ATG5, MSTN, LAMA2, BAX
19	mortality/aging	MP:0010768	4.8	GSN, LRP1, VLDLR, VCAM1, CD47, CD36
20	muscle phenotype	MP:0005369	4.7	GAA, APEX1, CD47, CD36, ATG5, MSTN
21	cellular phenotype	MP:0005384	3.6	GAA, EMD, RTN4, MAPT, APP, APOE
22	homeostasis/metabolism phenotype	MP:0005376	3.2	GAA, GAPDH, CST3, SQSTM1, CXCR3, PRNP

Articles related to inclusion body myositis:

(show top 50)    (show all 85)

id	Title	Authors	Year	Affiliating Genes
1	The association of sporadic inclusion body myositis a nd SjAPgren's syndrome in carriers of HLA-DR3 and the 8.1 MHC ancestral haplotyp e. (21507567)	Rojana-udomsart A.... Mastaglia F.L.	2011	HLA-DRB3
2	Increased BACE1 mRNA and noncoding BACE1-antisense tr anscript in sporadic inclusion-body myositis muscle fibers--possibly caused by endoplasmic reticulum stress. (20236612)	Nogalska A.... Askanas V.	2010	BACE1
3	Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)	Parker K.C.... Greenberg S.A.	2009	DNAH8
4	CCR7+ myeloid dendritic cells together with CCR7+ T cells and CCR7+ macrophages invade CCL19+ nonnecrotic muscle fibers in inclusion body myositis. (19171354)	Tateyama M.... Itoyama Y.	2009	CCL21, CCL19
5	p62/SQSTM1 is overexpressed and prominently accumulat ed in inclusions of sporadic inclusion-body myositis muscle fibers, and can hel p differentiating it from polymyositis and dermatomyositis. (19557423)	Nogalska A.... Askanas V.	2009	SQSTM1
6	Amyloid-beta42 is preferentially accumulated in muscl e fibers of patients with sporadic inclusion-body myositis. (19280202)	Vattemi G.... Askanas V.	2009	APP
7	Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis. (18216139)	Chen X.... Geiger J.D.	2008	APP
8	Sporadic inclusion body myositis: Phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. (18258695)	Needham M.... Mastaglia F.L.	2008	HLA-DRB1, HLA-DRB3
9	Apolipoprotein epsilon alleles in sporadic inclusion body myositis: a reappraisal. (18060780)	Needham M.... Mastaglia F.L.	2008	APOE
10	Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis. (17469125)	LA1nemann J.D.... MA1nz C.	2007	APP
11	Myostatin precursor protein is increased and associates with amyloid-beta precursor protein in inclusion-body myositis culture model. (17359364)	Wojcik S.... Askanas V.	2007	APP
12	Endoplasmic reticulum stress induces myostatin precursor protein and NF-kappaB in cultured human muscle fibers: relevance to inclusion body myositis. (17261282)	Nogalska A.... Askanas V.	2007	MSTN
13	Raised troponin T in inclusion body myositis is common and serum levels are persistent over time. (16920359)	Lindberg C.... Oldfors A.	2006	CHKB
14	MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle. (17077152)	Morosetti R.... Cossu G.	2006	MYOD1
15	AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)	Wojcik S.... Askanas V.	2006	APP, CRYAB
16	Neprilysin participates in skeletal muscle regeneration and is accumulated in abnormal muscle fibres of inclusion body myositis. (16405511)	Broccolini A.... Mirabella M.	2006	MME
17	Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis. (15912881)	Ferrer I.... OlivAc M.	2005	CLU, TUBG1
18	Messenger RNA degradation may be inhibited in sporadic inclusion body myositis. (16087907)	Nakano S.... Kusaka H.	2005	PABPC1P1
19	Myostatin is increased and complexes with amyloid-beta within sporadic inclusion-body myositis muscle fibers. (15983828)	Wojcik S.... Askanas V.	2005	MSTN
20	Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8+ T cell cytotoxicity. (15047591)	Schmidt J.... Dalakas M.C.	2004	GAPDH, ICOSLG
21	Inclusion body myositis after interferon-alpha treat ment in a patient with HCV and HTLV-1 infection (15515704)	Warabi Y.... Hayashi H.	2004	IFNA1
22	Two major histocompatibility complex haplotypes influence susceptibility to sporadic inclusion body myositis: critical evaluation of an association with HLA-DR3. (15496200)	Price P.... Laing N.	2004	HLA-A, HLA-DQB1, HLA-DRB1
23	Proteasomal expression, induction of immunoproteasome subunits, and local MHC class I presentation in myofibrillar myopathy and inclusion body myositis. (15198127)	Ferrer I.... OlivAc M.	2004	DES, GSN, RPS27A
24	Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)	Maurage C.A.... Delacourte A.	2004	MAPT
25	Expression of lysosome-related proteins and genes in the skeletal muscles of inclusion body myositis. (14513262)	Kumamoto T.... Tsuda T.	2004	ATG12, ATG5
26	Analysis of HLA class I and II alleles in sporadic inclusion-body myositis. (14648147)	Lampe J.B.... Lochmuller H.	2003	HLA-A, HLA-DQB1, HLA-DRB1
27	Expression of Bcl-2 in inclusion body myositis. (11982494)	Fyhr I.M.... Oldfors A.	2002	BCL2
28	Inclusion body myositis: morphological clues to correct diagnosis. (12398837)	Dahlbom K.... Oldfors A.	2002	HLA-B
29	Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle. (11839845)	Jaworska-Wilczynska M.... Askanas V.	2002	APP, MAPT, LRP1
30	Presence of BACE1 and BACE2 in muscle fibres of patients with sporadic inclusion-body myositis. (11747923)	Vattemi G.... Askanas V.	2001	BACE1, BACE2
31	Novel cytoplasmic immunolocalization of RNA polymeras e II in inclusion-body myositis muscle. (11435903)	Wilczynski G.M.... Askanas V.	2001	POLR2L
32	Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)	Zanusso G.... Monaco S.	2001	PRNP
33	Bcl-2, Bcl-x, and Bax expression by immunohistochemistry in inclusion body myositis: a study of 27 cases. (11570908)	Prayson R.A.... Yu A.C.	2001	BCL2L1, BAX
34	Novel immunolocalization of alpha-synuclein in human muscle of inclusion-body myositis, regenerating and necrotic muscle fibers, and at neuromuscular junctions. (10901230)	Askanas V.... Broccolini A.	2000	SNCA
35	Sporadic inclusion body myositis correlates with increased expression and cross-linking by transglutaminases 1 and 2. (10722712)	Choi Y.C.... Kim S.Y.	2000	TGM1
36	Redox factor-1 in muscle biopsies of patients with inclusion-body myositis. (10841976)	Broccolini A.... Askanas V.	2000	APEX1
37	AlphaB-crystallin immunolocalization yields new insig hts into inclusion body myositis. (10720271)	Banwell B.L.... Engel A.G.	2000	RPS27A
38	Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy. (9546349)	Askanas V.... Wisniewski T.	1998	APP, PSEN1
39	Diagnostic muscle MRI abnormality in a patient with inclusion body myositis (9805998)	Ono K.... Takamori M.	1998	CHKB
40	Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain. Recent approaches to diagnosis and pathogenesis, and relation to aging. (9855208)	Askanas V.... Engel W.K.	1998	APP, MAPT, PSEN1
41	Ubiquitin immunostaining and inclusion body myositis: study of 30 patients with inclusion body myositis. (9269823)	Prayson R.A.... Cohen M.L.	1997	RPS27A
42	Apolipoprotein E allele frequencies in sporadic inclusion body myositis. (8941276)	Love S.... Sherriff F.	1996	APOE
43	Apolipoprotein E and apolipoprotein E messenger RNA in muscle of inclusion body myositis and myopathies. (9007091)	Mirabella M.... Askanas V.	1996	APOE
44	Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau. (8291607)	Askanas V.... Selkoe D.J.	1994	MAPT
45	Ubiquitin expression in inclusion body myositis. An i mmunohistochemical study. (8393651)	Albrecht S.... Bilbao J.M.	1993	RPS27A
46	Strong immunoreactivity of alpha 1-antichymotrypsin co-localizes with beta-amyloid protein and ubiquitin in vacuolated muscle fibers of inclusion-body myositis. (8386897)	Bilak M.... Engel W.K.	1993	RPS27A, SERPINA3
47	Mitochondrial DNA deletions in inclusion body myositis. (8384916)	Oldfors A.... Holme E.	1993	COX5A, DNAH8
48	Ubiquitin and beta-amyloid-protein in inclusion body myositis (IBM), familial IBM-like disorder and oculopharyngeal muscular dystrop hy: an immunocytochemical study. (8268725)	Leclerc A.... Fardeau M.	1993	RPS27A
49	beta-Amyloid precursor protein mRNA is increased in inclusion-body myositis muscle. (8394158)	Sarkozi E.... Alvarez R.B.	1993	APP
50	Amyloid filaments in inclusion body myositis. Novel findings provide insight into nature of filaments. (1668977)	Mendell J.R.... Paul L.	1991	GAA

Genes related to inclusion body myositis according to GeneCards:

(show top 50)    (show all 81)

id	Symbol	Description	Score	GeneCards Section Context
1	APP	amyloid beta (A4) precursor protein	11.1	Summaries, Publications
2	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
3	CHKB	choline kinase beta	11.0	Publications
4	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
5	APOE	apolipoprotein E	11.0	Publications
6	PABPC1P1	poly(A) binding protein, cytoplasmic 1 pseudogene 1	11.0	Publications
7	RNF5	ring finger protein 5, E3 ubiquitin protein ligase	11.0	Publications
8	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	11.0	Publications
9	HSPB3	heat shock 27kDa protein 3	11.0
10	GNLY	granulysin	11.0	Publications
11	DUSP4	dual specificity phosphatase 4	11.0	Publications
12	NUS1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	11.0	Publications
13	ATG12	autophagy related 12	11.0	Publications
14	EMD	emerin	11.0	Publications
15	DUSP6	dual specificity phosphatase 6	11.0	Publications
16	MSTN	myostatin	11.0	Publications
17	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
18	ICOSLG	inducible T-cell co-stimulator ligand	11.0	Publications
19	MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	11.0	Publications
20	C4A	complement component 4A (Rodgers blood group)	11.0	Publications
21	CCL19	chemokine (C-C motif) ligand 19	11.0	Publications
22	CXCL11	chemokine (C-X-C motif) ligand 11	11.0	Publications
23	RPS27A	ribosomal protein S27a	11.0	Publications
24	TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
25	CFB	complement factor B	11.0	Publications
26	CCL21	chemokine (C-C motif) ligand 21	11.0	Publications
27	CD47	CD47 molecule	11.0	Publications
28	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	11.0	Publications
29	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
30	BACE1	beta-site APP-cleaving enzyme 1	11.0	Publications
31	VLDLR	very low density lipoprotein receptor	11.0	Publications
32	POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	11.0	Publications
33	PARK7	parkinson protein 7	11.0	Publications
34	BACE2	beta-site APP-cleaving enzyme 2	11.0	Publications
35	MYOD1	myogenic differentiation 1	11.0	Publications
36	MAPT	microtubule-associated protein tau	11.0	Publications
37	ATG5	autophagy related 5	11.0	Publications
38	VCP	valosin containing protein	11.0	Publications
39	UBB	ubiquitin B	11.0	Publications
40	TUBG1	tubulin, gamma 1	11.0	Publications
41	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
42	SQSTM1	sequestosome 1	11.0	Publications
43	RTN4	reticulon 4	11.0	Publications
44	CDK5	cyclin-dependent kinase 5	11.0	Publications
45	GAA	glucosidase, alpha; acid	11.0	Publications
46	CLU	clusterin	11.0	Publications
47	GSN	gelsolin	11.0	Publications
48	CRYAB	crystallin, alpha B	11.0	Publications
49	DUSP1	dual specificity phosphatase 1	11.0	Publications
50	PRNP	prion protein	11.0	Publications

Pathways related to inclusion body myositis according to GeneDecks:

(show all 38)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.8	ICOSLG
2	Regulation of autophagy20	10.6	ATG12, ATG5
3	RAR-Gamma-RXR-Alpha Degradation36	10.5	CXCL9, CXCL11, CCL19, CCL21, UBB
4	Reelin Pathway (Cajal-Retzius cells)36	10.5	MAPT, APP, APOE, APBB1, CDK5, VLDLR
5	Antigen processing and presentation20	10.3	HLA-DQB1, HLA-DRB1, HLA-DRB3
6	Alzheimers Disease Pathway36	10.3	PSEN1, MAPT, APP, APOE, CDK5, BACE2
7	Graft-versus-host disease20	10.2	HLA-DRB3, HLA-B, HLA-A
8	Staphylococcus aureus infection20	10.0	C4A, HLA-DRB3, HLA-DRB1, HLA-DQB1, ICAM1, CFB
9	Statin Pathway, Pharmacodynamics34	9.9	APOE, APOA1, LDLR, LRP1
10	Parkinsons Disease Pathway36	9.8	SNCA, TUBG1, UBB, PARK2, PARK7
11	CTL Mediated Apoptosis36	9.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A
12	Apoptosis and survival_Lymphotoxin-beta receptor signaling41	9.7	CCL19, CCL21, BAX, VCAM1
13	MIF Mediated Glucocorticoid Regulation36	9.7	CXCL9, CXCL11, CCL19, CCL21, BAX, BCL2
14	MIF Regulation of Innate Immune Cells36	9.7	CXCL9, CXCL11, CCL19, CCL21, BAX, BCL2
15	Cytoskeletal Signaling3	9.6	EMD, DES, TUBG1, CAV1, GSN, LMNA
16	STAT3 Pathway36	9.6	CXCR3, CXCL9, CXCL11, CCL19, CCL21, BAX
17	all-trans-Retinoic Acid Signaling in Brain36	9.5	CXCL9, CXCL11, CCL19, CCL21, BAX, BCL2
18	Neuroscience3	9.5	PSEN1, SNCA, MAPT, APP, APEX1, APBB1
19	Apoptosis and survival Lymphotoxin-beta receptor signaling10	9.5	CCL19, CCL21, BAX, VCAM1
20	Alzheimers disease20	9.4	LRP1, GAPDH, PSEN1, COX5A, SNCA, MAPT
21	Transendothelial Migration of Leukocytes36	9.4	ICAM1, CXCL11, CXCL9, CXCR3, CCL19, CCL21
22	Immune System38	9.4	SQSTM1, ICOSLG, ICAM1, IFNG, ATG5, ATG12
23	THC Differentiation Pathway36	9.4	HLA-DRB3, HLA-DRB1, HLA-DQB1, IFNG
24	PEDF Induced Signaling36	9.4	CXCL9, CXCL11, CCL19, CCL21, BAX, BCL2L1
25	Immune response IL-22 signaling pathway10	9.4	HLA-DRB3, HLA-DRB1, HLA-DQB1, BCL2L1, BCL2
26	Phagosome20	9.3	THBS1, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A
27	Immune response_IL-22 signaling pathway41	9.3	HLA-DRB3, HLA-DRB1, HLA-DQB1, BCL2L1, BCL2
28	African trypanosomiasis20	9.3	ICAM1, IFNG, APOA1, VCAM1
29	Malaria20	9.2	THBS1, ICAM1, IFNG, CD36, VCAM1, LRP1
30	Apoptosis and Autophagy3	9.2	SQSTM1, MAP1LC3A, ATG5, ATG12, BAX, BCL2L1
31	Allograft rejection20	9.1	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, IFNG
32	Protein processing in endoplasmic reticulum20	9.1	HERPUD1, RNF5, CRYAB, BAX, BCL2, PARK2
33	Rheumatoid arthritis20	9.1	IFNG, ICAM1, HLA-DQB1, HLA-DRB1, HLA-DRB3
34	Type I diabetes mellitus20	9.1	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, IFNG
35	Viral myocarditis20	8.9	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, CAV1
36	Autoimmune thyroid disease20	8.9	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, IFNA1
37	Toxoplasmosis20	8.0	HLA-DRB3, HLA-DRB1, HLA-DQB1, IFNG, LAMA2, LDLR
38	Tuberculosis20	7.9	HLA-DRB3, HLA-DRB1, HLA-DQB1, IFNG, IFNA1, BAX

Compounds related to inclusion body myositis according to GeneDecks:

(show top 50)    (show all 232)

id	Compound	Score	Top Affiliating Genes
1	thioflavin t32	9.8	GSN, APOE, APP, SNCA, TTR, THBS1
2	n acetylcysteine32	9.7	APEX1, APOE, MAPT, DUSP1, SNCA, RPS27A
3	sodium dodecylsulfate32	9.5	GAPDH, PRNP, DES, TGM1, TTR, RPS27A
4	4-hydroxynonenal32 18	10.2	SNCA, BAX, MME, BACE1, APOE, APP
5	threonine32	9.1	MYLK, MYOD1, PARK2, DUSP1, CDK5, MAPT
6	pge232	9.0	PRNP, VCAM1, MME, CCL21, CCL19, SNCA
7	methionine32	9.0	GSN, PARK7, SERPINA3, HELLS, CST3, MAPT
8	phosphatidylserine32 9 9	11.0	BCL2, CD47, GSN, MAPT, CAV1, SNCA
9	doxorubicin32 34 9 9	11.9	COX5A, HELLS, RPS27A, BCL2L1, MAPT, CAV1
10	lysine32	8.9	GNLY, MME, BACE1, LDLR, CHKB, PARK2
11	aspartate32	8.8	MYLK, CST3, DNAH8, RPS27A, CRYAB, CHKB
12	glucose32	8.8	MYLK, MYOD1, PARK2, GAA, GAPDH, DES
13	glutamate32	8.8	GAPDH, HELLS, COX5A, RPS27A, SNCA, CAV1
14	folate32	8.8	LDLR, APOE, APP, DNAH8, CST3, MAPT
15	chloroquine32 34 9 9	11.8	BACE1, IFNA1, GAA, THBS1, RPS27A, CAV1
16	dopamine32 9 18 9	11.7	CLU, PARK2, PARK7, SERPINA3, CHKB, CDK5
17	heparin32 9 18 9	11.5	GAPDH, CXCR3, PRNP, DES, SNCA, DUSP1
18	polysaccharide32	8.5	PRNP, DNAH8, THBS1, RPS27A, SNCA, HLA-B
19	agarose32	8.4	PRNP, SNCA, CFB, BAX, CHKB, BCL2L1
20	acetylcholine32 9 18 9	11.4	MME, APOA1, APOE, APP, MAPT, CAV1
21	creatinine32	8.4	VLDLR, DES, CXCL9, CXCR3, GAPDH, DNAH8
22	estrogen32	8.3	SERPINA3, MYLK, MYOD1, CLU, PARK2, CHKB
23	superoxide32 18	9.2	GAPDH, CST3, CXCR3, PRNP, PSEN1, COX5A
24	lactacystin32	8.1	SNCA, RPS27A, PSEN1, IFNG, MYOD1, PARK2
25	glutamine32	7.8	SNCA, HLA-DQB1, MAPT, APP, VCP, PARK2
26	adenylate32	7.7	DES, HLA-A, HLA-B, SNCA, RPS27A, TTR
27	h2o232	7.7	PRNP, PSEN1, DES, HELLS, RPS27A, CRYAB
28	nitric oxide32 9 18 9	10.6	COX5A, DUSP6, THBS1, TGM1, DES, CXCL9
29	cholesterol32 9 18 9	10.5	VCAM1, CST3, CXCR3, PRNP, LMNA, CLU
30	calcium32 9 18 9	10.5	PSEN1, DNAH8, TGM1, SNCA, DUSP1, CAV1
31	tacrolimus32 34 9 9	10.5	CHKB, CD36, APOA1, HLA-B, GAPDH, CXCR3
32	cysteine32	7.2	LRP1, SERPINA3, CLU, PARK7, BCL2L1, CHKB
33	arginine32	7.1	APOE, MME, CDK5, LDLR, CHKB, MYOD1
34	paraffin32	7.1	APEX1, MME, CD36, BAX, CHKB, BCL2L1
35	atp32	7.1	CDK5, APEX1, CAV1, POLR2L, CXCL9, DNAH8
36	vegf32	7.0	CHKB, BCL2L1, BCL2, PARK2, CLU, MYOD1
37	tamoxifen32 34 9 9	10.0	LDLR, CHKB, BCL2, CLU, BAX, APOA1
38	testosterone32 9 18 9	9.9	MME, GSN, APOA1, APOE, APP, MAPT
39	oxygen32 18	7.8	SERPINA3, MYLK, GAPDH, SQSTM1, BAX, BACE1
40	cyclosporin a32 42	7.7	ICAM1, IFNG, IFNA1, MAPT, APP, APOE
41	lipid32	6.4	MME, VCAM1, VLDLR, SERPINA3, BACE1, LRP1
42	actinomycin d32	6.4	GAPDH, POLR2L, DES, RPS27A, CRYAB, DUSP1
43	alanine32	6.3	HELLS, HLA-DRB1, HLA-A, CAV1, IFNA1, APOA1
44	genistein32 9 18 9	9.1	IFNG, CAV1, DUSP1, COX5A, TTR, THBS1
45	oligonucleotide32	6.1	LRP1, THBS1, PSEN1, CXCL11, POLR2L, GAPDH
46	cycloheximide32	5.9	DUSP1, CAV1, ICAM1, GAPDH, IFNA1, RPS27A
47	dexamethasone32 42 34 9 9	9.1	POLR2L, CST3, CXCR3, CXCL9, CXCL11, THBS1
48	retinoic acid32 42 18	6.6	MAPT, IFNA1, IFNG, ICAM1, HLA-B, DUSP1
49	tyrosine32	4.6	LRP1, VLDLR, APBB1, VCAM1, ICAM1, CAV1
50	serine32	3.2	CD47, MME, GSN, APEX1, APOA1, APOE

Cellular components related to inclusion body myositis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle membrane	GO:030666	9.9	RPS27A, HLA-DRB3, HLA-DRB1, HLA-DQB1, CAV1, UBB
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.6	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A
3	ER to Golgi transport vesicle membrane	GO:012507	9.6	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A
4	clathrin-coated endocytic vesicle membrane	GO:030669	9.6	HLA-DRB3, HLA-DRB1, HLA-DQB1, LDLR
5	axon	GO:030424	9.5	SNCA, MAPT, APP, MME, CDK5, PARK7
6	cell surface	GO:009986	9.2	CRYAB, CAV1, APP, CD36, BACE2, BACE1
7	perinuclear region of cytoplasm	GO:048471	8.7	GAPDH, SNCA, CAV1, APEX1, APBB1, GSN
8	external side of plasma membrane	GO:009897	8.5	VCAM1, CXCR3, CXCL9, THBS1, HLA-DRB3, HLA-DRB1
9	extracellular space	GO:005615	8.4	GNLY, C4A, TTR, THBS1, CXCL11, CXCL9
10	endoplasmic reticulum	GO:005783	8.2	CAV1, PSEN1, PRNP, SQSTM1, RTN4, EMD
11	integral to plasma membrane	GO:005887	8.0	CAV1, HLA-A, HLA-B, HLA-DRB1, HLA-DRB3, PSEN1
12	extracellular region	GO:005576	7.9	IFNG, SNCA, C4A, TTR, THBS1, CXCL11
13	cytosol	GO:005829	6.9	MAPT, MAP1LC3A, CAV1, TUBG1, SNCA, CRYAB
14	plasma membrane	GO:005886	6.4	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, CAV1
15	cytoplasm	GO:005737	6.2	APEX1, APOE, APP, HSPB3, TUBG1, DUSP6

Biological processes related to inclusion body myositis according to GeneDecks:

(show all 35)

id	Name	GO ID	Score	Top Affiliating Genes
1	autophagic vacuole assembly	GO:000045	10.6	MAP1LC3A, ATG5, ATG12
2	negative regulation of type I interferon production	GO:032480	10.5	UBB, ATG12, ATG5, RPS27A
3	positive regulation of chemotaxis	GO:050921	10.5	THBS1, CCL19, CCL21
4	stress-activated MAPK cascade	GO:051403	10.5	RPS27A, CRYAB, DUSP6, DUSP4, UBB
5	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.3	HLA-DQB1, HLA-DRB1, HLA-DRB3
6	humoral immune response mediated by circulating immunoglobulin	GO:002455	10.3	HLA-DQB1, HLA-DRB1, HLA-DRB3
7	cellular response to hypoxia	GO:071456	10.2	RPS27A, ICAM1, UBB, LMNA, VLDLR
8	nerve growth factor receptor signaling pathway	GO:048011	10.1	RTN4, SQSTM1, PSEN1, RPS27A, DUSP6, DUSP4
9	positive regulation of protein kinase activity	GO:045860	10.1	CCL19, CCL21, CDK5, VLDLR
10	T cell receptor signaling pathway	GO:050852	10.0	PSEN1, RPS27A, HLA-DRB3, HLA-DRB1, HLA-DQB1, UBB
11	positive regulation of endocytosis	GO:045807	10.0	SNCA, CAV1, CCL19
12	T cell costimulation	GO:031295	10.0	HLA-DRB3, HLA-DRB1, HLA-DQB1, CAV1, ICOSLG, CCL19
13	detection of bacterium	GO:016045	9.9	HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
14	induction of apoptosis by extracellular signals	GO:008624	9.9	SQSTM1, PSEN1, RPS27A, CAV1, BAX, UBB
15	platelet degranulation	GO:002576	9.9	THBS1, APP, APOA1, CD36, CLU
16	muscle organ development	GO:007517	9.8	GAA, EMD, CRYAB, MSTN, LAMA2, MYOD1
17	positive regulation of anti-apoptosis	GO:045768	9.8	DUSP1, CAV1, APEX1, BCL2L1
18	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	9.8	BCL2, BCL2L1, UBB, APP, RPS27A
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	9.8	UBB, CD36, HLA-A, HLA-B, RPS27A
20	neuron migration	GO:001764	9.8	BAX, CDK5, APBB1, MAPT, PSEN1
21	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	9.7	RPS27A, HLA-B, HLA-A, CD36, UBB
22	cholesterol transport	GO:030301	9.7	CAV1, APOA1, CD36, LDLR
23	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.6	RPS27A, CCL19, CCL21, CD36, UBB, PARK2
24	neuron apoptotic process	GO:051402	9.6	GAPDH, PSEN1, APP, CDK5, BAX, BCL2
25	release of cytochrome c from mitochondria	GO:001836	9.4	BAX, BCL2L1, BCL2, CLU
26	innate immune response	GO:045087	9.4	C4A, RPS27A, DUSP6, DUSP4, APP, ATG5
27	immune response	GO:006955	9.4	CXCL9, CXCL11, THBS1, HLA-DRB3, HLA-DRB1, HLA-DQB1
28	regulation of mitochondrial membrane potential	GO:051881	9.3	BAX, BCL2L1, BCL2
29	anti-apoptosis	GO:006916	9.0	BCL2, SQSTM1, PRNP, PSEN1, THBS1, RPS27A
30	ovarian follicle development	GO:001541	8.7	ICAM1, BAX, BCL2L1, BCL2
31	interferon-gamma-mediated signaling pathway	GO:060333	8.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, ICAM1
32	response to drug	GO:042493	8.7	THBS1, SNCA, DUSP6, CAV1, ICAM1, IFNG
33	negative regulation of neuron apoptotic process	GO:043524	8.7	PSEN1, SNCA, BAX, BCL2L1, BCL2, PARK2
34	cytokine-mediated signaling pathway	GO:019221	8.5	RPS27A, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A
35	apoptotic process	GO:006915	8.0	IFNG, RPS27A, PSEN1, CXCR3, SQSTM1, RTN4

Molecular functions related to inclusion body myositis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	beta-amyloid binding	GO:001540	10.0	CST3, APOE, APOA1, APBB1
2	MHC class II receptor activity	GO:032395	10.0	HLA-DQB1, HLA-DRB1, HLA-DRB3
3	apolipoprotein binding	GO:034185	9.9	LRP1, VLDLR, MAPT
4	low-density lipoprotein receptor activity	GO:005041	9.7	CD36, LDLR, VLDLR
5	BH3 domain binding	GO:051434	9.3	BAX, BCL2L1, BCL2
6	receptor binding	GO:005102	9.0	HLA-B, HLA-A, CAV1, ICOSLG, APP, MSTN
7	identical protein binding	GO:042802	8.4	SNCA, THBS1, PRNP, SQSTM1, APP, APOE
8	protein binding	GO:005515	3.6	GAPDH, SNCA, DUSP1, TUBG1, HLA-DRB3, HLA-A