IBM
MCID: INC002
MIFTS: 86

Inclusion Body Myositis (IBM) malady

Genetic diseases, Rare diseases, Neuronal diseases, Metabolic diseases, Muscle diseases categories
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Summaries for Inclusion Body Myositis

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NIH Rare Diseases:42 Inclusion body myopathy 2, also known as hereditary inclusion body myopathy (hibm), gne-related myopathy,  distal myopathy with rimmed vacuoles, and nonaka myopathy, is an inherited condition that primarily affects the skeletal muscles (the muscles that the body uses to move). this disorder is characterized by muscle weakness that appears in late adolescence or early adulthood and worsens over time. early symptoms typically develop in the 20s and 30s and may include difficulty running or walking, tripping, weakness in the index finger, and frequent loss of balance. inclusion body myopathy 2 is caused by mutations in the gne gene. the condition is inherited in an autosomal recessive manner. treatment is focused on managing individual symptoms. last updated: 1/13/2014

MalaCards based summary: Inclusion Body Myositis, also known as nonaka myopathy, is related to myositis and dementia, and has symptoms including muscle weakness/flaccidity, muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy and abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase. An important gene associated with Inclusion Body Myositis is MYH2 (myosin, heavy chain 2, skeletal muscle, adult), and among its related pathways are A-beta Uptake and Degradation and Alzheimers Disease Pathway. The drugs carisoprodol and chlorphenesin and the compounds metrifonate and 24s-hydroxy-cholesterol have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, t cells and brain, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Disease Ontology:8 A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.

Genetics Home Reference:21 Inclusion body myopathy 2 is a condition that primarily affects skeletal muscles, which are muscles that the body uses for movement. This disorder causes muscle weakness that appears in late adolescence or early adulthood and worsens over time.

NINDS:43 Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.

Wikipedia:65 Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive... more...

Descriptions from OMIM:46 605820,147421,600737,605637

Aliases & Classifications for Inclusion Body Myositis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 48Orphanet, 46OMIM, 62UMLS, 21Genetics Home Reference, 9diseasecard, 22GTR, 44Novoseek, 20GeneTests, 34MeSH, 57SNOMED-CT, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Inclusion Body Myositis, Aliases & Descriptions:

Name: Inclusion Body Myositis 8 42 43 10 48 46 62
Nonaka Myopathy 8 9 42 22 21 46 44 48 62
Distal Myopathy with Rimmed Vacuoles 8 42 21 48 62
Inclusion Body Myopathy 2 8 42 22 21 62
Hereditary Inclusion Body Myopathy 8 42 21 62
Inclusion Body Myopathy-3 9 20 22 46
Ibm2 8 42 21 48
Dmrv 42 21 48 62
Inclusion Body Myopathy, Autosomal Recessive 42 21 46
Inclusion Body Myopathy 3 8 42 62
Rimmed Vacuole Myopathy 42 21 62
Hibm 8 42 21
Hereditary Inclusion Body Myopathy - Joint Contractures - Ophthalmoplegia 42 48
Inclusion Body Myopathy, Quadriceps-Sparing 42 21
Hereditary Inclusion Body Myopathy Type 3 42 48
Distal Myopathy, Nonaka Type 8 48
Inflammatory Myopathy 42 62
Gne Myopathy 42 48
Hibm3 42 48
Ibm3 42 48
 
Ibm 42 48
Qsm 42 21
Myopathy with Congenital Joint Contractures, Ophthalmoplegia, and Rimmed Vacuoles 42
Inclusion Body Myopathy 3, Autosomal Dominant 62
Inclusion Body Myopathy Autosomal Recessive 62
Inclusion Body Myopathy, Autosomal Dominant 62
Inclusion Body Myopathy Autosomal Dominant 42
Hereditary Inclusion Body Myopathy Type 2 48
Inclusion Body Myopathy, Sporadic 62
Sporadic Inclusion Body Myositis 48
Inclusion Body Myopathy Type 3 48
Inclusion Body Myopathy Type 2 48
Quadriceps Sparing Myopathy 42
Quadriceps-Sparing Myopathy 48
Myopathies, Inflammatory 62
Inflammatory Myopathies 43
Myositis Inclusion Body 44
Ibm-3 8
Hibm2 48
Sibm 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
inclusion body myositis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood; Age of death: Normal
nonaka myopathy:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000; Age of onset: Adulthood
hereditary inclusion body myopathy - joint contractures - ophthalmoplegia:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy


External Ids:

Disease Ontology8 DOID:3429
MeSH34 D018979
ICD9CM27 359.71
NCIt39 C84786
SNOMED-CT57 72315009
ICD10 via Orphanet26 M60.8, G71.8
UMLS via Orphanet63 C0238190
MESH via Orphanet35 C536816
ICD1025 G72.4

Related Diseases for Inclusion Body Myositis

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Diseases related to Inclusion Body Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1myositis32.6MSTN, RPS27A, APP, CHKB
2dementia31.1RPS27A, APOE, APP
3frontotemporal dementia31.0APOE, APP, RPS27A
4muscular dystrophy30.9MSTN, CHKB, GNE
5alzheimer's disease30.8APP, CHKB, APOE, CXCR3, RPS27A
6myopathy30.7MSTN, CHKB, MYH2, APP, GNE, RPS27A
7tauopathy30.7RPS27A, APP
8creutzfeldt-jakob disease30.7APP, APOE, RPS27A
9rheumatoid arthritis30.7CXCR3, CXCL11, CHKB, CXCL9
10amyloidosis30.7APOE, RPS27A, APP
11parkinson's disease30.5APOE, APP, CHKB, RPS27A
12sialuria30.5GNE
13neuromuscular disease30.4GNE, CHKB, MSTN
14systemic lupus erythematosus30.3CXCR3, RPS27A, C4A
15polymyositis10.9
16dermatomyositis10.9
17dysphagia10.8
18ophthalmoplegia10.7
19idiopathic myopathy10.5
20interstitial lung disease10.5
21hepatitis10.5
22hepatitis c10.5
23oculopharyngeal muscular dystrophy10.5
24meningoencephalitis10.5APP
25inflammatory myopathy with abundant macrophages10.5
26progressive supranuclear palsy10.5APOE
27semantic dementia10.4RPS27A
28lewy body dementia10.4APOE
29arthritis10.4
30leukemia10.4
31neuropathy10.4
32respiratory failure10.4
33myofibrillar myopathy10.4
34hepatitis c virus10.4
35distal muscular dystrophy10.4
36atrioventricular block10.4
37restrictive cardiomyopathy10.4
38oculopharyngodistal myopathy10.4
39hereditary inclusion body myopathy type 410.4
40encephalitis10.4APP, CXCL9
41binswanger's disease10.4APP, APOE
42stroke, hemorrhagic10.4APOE, APP
43gne-related myopathy10.4
44proliferative glomerulonephritis10.4CXCL9, CXCR3
45malaria10.4CXCL9
46neuroaxonal dystrophy, infantile10.4RPS27A, APP
47contact dermatitis10.4CXCR3, CXCL9
48alzheimer disease type 210.4APOE, APP
49cerebral amyloid angiopathy10.4APOE, APP
50common variable immunodeficiency10.4

Graphical network of the top 20 diseases related to Inclusion Body Myositis:



Diseases related to inclusion body myositis

Symptoms for Inclusion Body Myositis

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Symptoms by clinical synopsis from OMIM:

147421

Clinical features from OMIM:

605820,147421,600737,605637

Symptoms:

48 (show all 8)
  • muscle weakness/flaccidity
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • autoimmunity/autoimmune reaction/autoantibodies
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • areflexia/hyporeflexia
  • myalgia/muscular pain

HPO human phenotypes related to Inclusion Body Myositis:

(show all 41)
id Description Frequency HPO Source Accession
1 muscle weakness hallmark (90%) HP:0001324
2 autoimmunity hallmark (90%) HP:0002960
3 amyotrophy hallmark (90%) HP:0003202
4 emg abnormality hallmark (90%) HP:0003457
5 reduced tendon reflexes typical (50%) HP:0001315
6 feeding difficulties in infancy typical (50%) HP:0008872
7 myalgia occasional (7.5%) HP:0003326
8 autosomal dominant inheritance HP:0000006
9 hyporeflexia HP:0001265
10 abnormality of metabolism/homeostasis HP:0001939
11 dysphagia HP:0002015
12 distal muscle weakness HP:0002460
13 slow progression HP:0003677
14 proximal muscle weakness HP:0003701
15 sporadic HP:0003745
16 rimmed vacuoles HP:0003805
17 phenotypic variability HP:0003812
18 inflammatory myopathy HP:0009071
19 autosomal recessive inheritance HP:0000007
20 gait disturbance HP:0001288
21 elevated serum creatine phosphokinase HP:0003236
22 limb-girdle muscle weakness HP:0003325
23 emg HP:0003458
24 adult onset HP:0003581
25 distal amyotrophy HP:0003693
26 proximal muscle weakness HP:0003701
27 deposits immunoreactive to beta-amyloid protein HP:0003791
28 limb-girdle muscle atrophy HP:0003797
29 rimmed vacuoles HP:0003805
30 autosomal recessive inheritance HP:0000007
31 myopathy HP:0003198
32 muscle fiber inclusion bodies HP:0100299
33 autosomal recessive inheritance HP:0000007
34 gait disturbance HP:0001288
35 distal muscle weakness HP:0002460
36 elevated serum creatine phosphokinase HP:0003236
37 emg HP:0003458
38 adult onset HP:0003581
39 distal amyotrophy HP:0003693
40 deposits immunoreactive to beta-amyloid protein HP:0003791
41 rimmed vacuoles HP:0003805

Drugs & Therapeutics for Inclusion Body Myositis

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Genetic Tests for Inclusion Body Myositis

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Genetic tests related to Inclusion Body Myositis:

id Genetic test Affiliating Genes
1 Inclusion Body Myopathy 320 22 MYH2
2 Inclusion Body Myopathy 222
3 Nonaka Myopathy22

Anatomical Context for Inclusion Body Myositis

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MalaCards organs/tissues related to Inclusion Body Myositis:

32
Skeletal muscle, T cells, Brain, Testes, Myeloid, Heart, Thyroid, Skin, Endothelial

Animal Models for Inclusion Body Myositis or affiliated genes

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MGI Mouse Phenotypes related to Inclusion Body Myositis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5GNE, APOE, CXCR3, MSTN, TREX1
2MP:00053857.9TREX1, MSTN, CXCR3, DUSP6, APOE, GNE
3MP:00053697.8TREX1, GNE, APOE, APP, DUSP6, CHKB
4MP:00053767.4GNE, APOE, APP, DUSP6, CHKB, CXCR3
5MP:00053877.2GNE, APOE, APP, DUSP6, CXCL9, CXCR3
6MP:00107687.0GNE, APOE, APP, DUSP6, CXCL9, CXCR3

Publications for Inclusion Body Myositis

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Articles related to Inclusion Body Myositis:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Mechanical ventilation weaning in inclusion body myositis: feasibility of isokinetic inspiratory muscle training as an adjunct therapy. (25147743)
2014
2
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
3
188th ENMC International Workshop: Inclusion Body Myositis, 2-4 December 2011, Naarden, The Netherlands. (24268584)
2013
4
Inclusion-body myositis associated with Alzheimer's disease. (23606855)
2013
5
The effect of anakinra, an IL1 receptor antagonist, in patients with sporadic inclusion body myositis (sIBM): a small pilot study. (23998706)
2013
6
Inclusion body myositis. (23250766)
2013
7
Inclusion body myositis associated with SjAPgren's syndrome. (23233115)
2013
8
TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]. (23023438)
2012
9
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study. (22554526)
2012
10
TWEAK in inclusion-body myositis muscle: possible pathogenic role of a cytokine inhibiting myogenesis. (22314077)
2012
11
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1I^-induced accumulation of I^-amyloid and cell death. (22436237)
2012
12
Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution? (20044785)
2012
13
Inclusion body myositis: diagnosis, pathogenesis, and treatment options. (21444018)
2011
14
TDP-43 plasma levels do not differentiate sporadic inclusion body myositis from other inflammatory myopathies. (21046407)
2010
15
Inclusion body myositis masquerading as amyotrophic lateral sclerosis. (21059520)
2010
16
Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)
2009
17
Detecting dysphagia in inclusion body myositis. (19603245)
2009
18
TDP-43: a reliable immunohistochemistry marker for inclusion body myositis? (19533631)
2009
19
Inclusion body myositis and HIV infection. (18641890)
2008
20
Interplay between inflammation and degeneration: using inclusion body myositis to study &quot;neuroinflammation&quot;. (18626972)
2008
21
Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. (18258695)
2008
22
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)
2006
23
Inclusion body myositis: an underdiagnosed myopathy of older people. (16364943)
2006
24
Messenger RNA degradation may be inhibited in sporadic inclusion body myositis. (16087907)
2005
25
Steroid-responsive inclusion body myositis associated with endometrial cancer. (15789894)
2005
26
Sporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres. (15146016)
2004
27
119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. (15099594)
2004
28
Insulin-like growth factor I in inclusion-body myositis and human muscle cultures. (15217093)
2004
29
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
30
Inclusion body myositis: clonal expansions of muscle-infiltrating T cells persist over time. (12869141)
2003
31
Anti-PM-Scl antibodies in a patient with inclusion body myositis. (12869677)
2003
32
Primary SjAPgren's syndrome associated with inclusion body myositis. (11961175)
2002
33
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)
2001
34
Bcl-2, Bcl-x, and Bax expression by immunohistochemistry in inclusion body myositis: a study of 27 cases. (11570908)
2001
35
Prion codon 129 homozygosity and sporadic inclusion body myositis. (11468340)
2001
36
Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex. (10380695)
1999
37
Dermatomyositis. Diagnosis and evaluation of dermatomyositis, polymyositis, and inclusion-body myositis. (10599341)
1999
38
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis. (9596410)
1998
39
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
40
Intracellular phosphates in inclusion body myositis--a 31P magnetic resonance spectroscopy study. (9771678)
1998
41
Inflammatory myopathies [polymyositis, dermatomyositis, inclusion body myositis]. (9801848)
1998
42
Hepatitis C and inclusion body myositis. (8792712)
1996
43
Sporadic inclusion body myositis: counts of different types of abnormal fibers. (8572661)
1996
44
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
45
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
46
Inclusion body myositis: analysis of 32 cases. (1331441)
1992
47
Inclusion body myositis with abundant ring fibers. (1337419)
1992
48
Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis. (1321564)
1992
49
Familial inclusion body myositis among Kurdish-Iranian Jews. (1850594)
1991
50
Clinically unsuspected inclusion body myositis. (1850803)
1991

Variations for Inclusion Body Myositis

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UniProtKB/Swiss-Prot genetic disease variations for Inclusion Body Myositis:

64 (show all 38)
id Symbol AA change Variation ID SNP ID
1GNEp.Pro36LeuVAR_017945
2GNEp.Ile200PheVAR_017946
3GNEp.Asp225AsnVAR_017947
4GNEp.Arg246GlnVAR_017948
5GNEp.Arg246TrpVAR_017949
6GNEp.Cys303ValVAR_017953
7GNEp.Asp378TyrVAR_017954
8GNEp.Asp378TyrVAR_017954
9GNEp.Ala460ValVAR_017955
10GNEp.Ala460ValVAR_017955
11GNEp.Ala524ValVAR_017956
12GNEp.Phe528CysVAR_017957
13GNEp.Ile557ThrVAR_017958
14GNEp.Val572LeuVAR_017959rs121908632
15GNEp.Val572LeuVAR_017959rs121908632
16GNEp.Gly576GluVAR_017960
17GNEp.Ile587ThrVAR_017961
18GNEp.Ala631ThrVAR_017962
19GNEp.Ala631ValVAR_017963
20GNEp.Ala631ValVAR_017963
21GNEp.Tyr675HisVAR_017964
22GNEp.Val696MetVAR_017965rs121908627
23GNEp.Met712ThrVAR_017966rs28937594
24GNEp.Pro27SerVAR_021771
25GNEp.His132GlnVAR_021772
26GNEp.Arg162CysVAR_021773
27GNEp.Met171ValVAR_021774
28GNEp.Asp176ValVAR_021775rs139425890
29GNEp.Arg177CysVAR_021776
30GNEp.Gly206SerVAR_021777
31GNEp.Val216AlaVAR_021778
32GNEp.Arg306GlnVAR_021779
33GNEp.Val331AlaVAR_021780
34GNEp.Ile472ThrVAR_021781
35GNEp.Asn519SerVAR_021782
36GNEp.Ala600ThrVAR_021783
37GNEp.Ala630ThrVAR_021784
38MYH2p.Glu706LysVAR_032630

Clinvar genetic disease variations for Inclusion Body Myositis:

6 (show all 14)
id Gene Name Type Significance SNP ID Assembly Location
1MYH2NM_017534.5(MYH2): c.2116G> A (p.Glu706Lys)single nucleotide variantPathogenicrs121434589GRCh37Chr 17, 10438454: 10438454
2GNENM_001128227.2(GNE): c.620A> T (p.Asp207Val)single nucleotide variantPathogenicrs139425890GRCh37Chr 9, 36246117: 36246117
3GNENM_001128227.2(GNE): c.2228T> C (p.Met743Thr)single nucleotide variantPathogenicrs28937594GRCh37Chr 9, 36217396: 36217396
4GNENM_001128227.2(GNE): c.1820G> A (p.Gly607Glu)single nucleotide variantPathogenicrs121908625GRCh37Chr 9, 36219924: 36219924
5GNENM_001190383.1(GNE): c.1669G> A (p.Ala557Thr)single nucleotide variantPathogenicrs121908626GRCh37Chr 9, 36218222: 36218222
6GNENM_001190383.1(GNE): c.1864G> A (p.Val622Met)single nucleotide variantPathogenicrs121908627GRCh37Chr 9, 36217445: 36217445
7GNENM_001128227.2(GNE): c.1002T> A (p.Cys334Ter)single nucleotide variantPathogenicrs121908628GRCh37Chr 9, 36233990: 36233990
8GNENM_001128227.2(GNE): c.830G> A (p.Arg277Gln)single nucleotide variantPathogenicrs121908629GRCh37Chr 9, 36236861: 36236861
9GNENM_001128227.2(GNE): c.766G> A (p.Asp256Asn)single nucleotide variantPathogenicrs121908630GRCh37Chr 9, 36236925: 36236925
10GNENM_001128227.2(GNE): c.1472C> T (p.Ala491Val)single nucleotide variantPathogenicrs121908631GRCh37Chr 9, 36223402: 36223402
11GNENM_001128227.2(GNE): c.1807G> C (p.Val603Leu)single nucleotide variantPathogenicrs121908632GRCh37Chr 9, 36219937: 36219937
12GNENM_001128227.2(GNE): c.1000_1001delTGinsGT (p.Cys334Val)indelPathogenicrs121908633GRCh37Chr 9, 36233991: 36233992
13GNENM_001128227.2(GNE): c.1985C> T (p.Ala662Val)single nucleotide variantPathogenicrs62541771GRCh37Chr 9, 36218221: 36218221
14GNENM_001128227.2(GNE): c.604A> G (p.Met202Val)single nucleotide variantPathogenicrs121908634GRCh37Chr 9, 36246133: 36246133

Expression for genes affiliated with Inclusion Body Myositis

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Expression patterns in normal tissues for genes affiliated with Inclusion Body Myositis

Search GEO for disease gene expression data for Inclusion Body Myositis.

Pathways for genes affiliated with Inclusion Body Myositis

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Pathways related to Inclusion Body Myositis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8APP, APOE
29.8APP, APOE
3
Show member pathways
9.3APP, RPS27A, TREX1
49.1CXCL9, CXCR3, CXCL11
5
Show member pathways
9.1CXCL9, CXCL11, CXCR3
6
Show member pathways
9.1CXCL9, CXCL11, CXCR3
7
Show member pathways
8.9RPS27A, DUSP6, APP
8
Show member pathways
8.9MYH2, CXCL9, CXCL11, CXCR3
9
Show member pathways
8.9CXCR3, MYH2, CXCL9, CXCL11
10
Show member pathways
8.8CXCR3, CXCL11, APP, CXCL9
11
Show member pathways
7.2DUSP6, CXCL9, CXCL11, CXCR3, RPS27A, APOE

Compounds for genes affiliated with Inclusion Body Myositis

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Compounds related to Inclusion Body Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1metrifonate4410.3APOE, APP
224s-hydroxy-cholesterol4410.2APP, APOE
3thioflavin t4410.2APP, APOE
4edss4410.2APOE, CXCR3
5tacrine44 1111.2APP, APOE
6donepezil44 50 24 1113.2APP, APOE
7galantamine44 50 1112.1APP, APOE
8gemfibrozil28 44 1112.0CHKB, APOE
9cysteamine44 24 1112.0RPS27A, APOE
10rosuvastatin44 50 28 1112.9CHKB, APOE
11lovastatin44 50 61 28 1113.9CHKB, APP, APOE
12simvastatin44 50 61 28 24 1114.9CHKB, APP, APOE
13thioflavine s449.8APOE, APP, RPS27A
14groalpha449.8CXCR3, CXCL9
15guanidine44 24 1111.8CHKB, APOE
16formate449.8RPS27A, APP, APOE
174-hydroxynonenal44 2410.8APOE, APP, RPS27A
18guanidine hydrochloride449.8RPS27A, CHKB, APOE
19chloroquine44 2 50 28 1113.8RPS27A, APP, APOE
20lactacystin449.8APOE, APP, RPS27A
21sodium dodecylsulfate449.8APOE, APP, RPS27A
22spec-t449.7CHKB, APOE
23sodium nitroprusside449.7APP, CXCL9, CXCR3
24valine449.7APOE, APP, RPS27A
25epinephrine44 24 1111.6APP, CHKB, RPS27A
26tacrolimus44 50 1111.5APP, CHKB, CXCR3, RPS27A
27tarc449.5CXCR3, CXCL11, CXCL9
28ccl344 2810.5CXCL9, CXCL11, CXCR3
29heparin44 28 24 1112.5APOE, APP, CHKB, CXCR3
30ccl444 2810.5CXCR3, CXCL11, CXCL9
31aspirin44 50 28 2412.5RPS27A, CHKB, APP, APOE
32cholesterol44 28 24 1112.5APOE, APP, CHKB, CXCR3
33glutamine449.4RPS27A, CHKB, APP, APOE
34n acetylcysteine449.4APOE, CHKB, RPS27A
35dopamine44 28 24 1112.4APOE, APP, CHKB, RPS27A
36aspartate449.4APOE, APP, CHKB, RPS27A
37tamoxifen44 50 28 1112.4RPS27A, CHKB, APOE
38rantes449.4CXCR3, CXCL11, CXCL9
39endotoxin449.1CHKB, CXCL9, CXCR3, C4A
40testosterone44 61 24 1112.1APOE, APP, CHKB, MSTN, RPS27A
41lysophosphatidylcholine28 4410.1CXCL9, CXCL11
42cyclosporin a44 28 6111.0APOE, APP, CHKB, CXCL11, RPS27A
43h2o2448.7APOE, APP, DUSP6, CHKB, RPS27A
44creatinine448.7APOE, APP, CHKB, CXCL9, CXCR3, RPS27A
45vegf448.7APOE, APP, CHKB, CXCL9, CXCR3, RPS27A
46cysteine448.6APOE, APP, DUSP6, CHKB, RPS27A
47oxygen44 249.4DUSP6, CHKB, CXCR3, MSTN, C4A
48dexamethasone44 50 28 1111.1APP, CHKB, CXCL9, CXCL11, CXCR3, MSTN
49calcium44 50 24 1111.0DUSP6, MYH2, CHKB, CXCL9, CXCL11, CXCR3
50arginine447.6C4A, RPS27A, CXCR3, CXCL11, CXCL9, CHKB

GO Terms for genes affiliated with Inclusion Body Myositis

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Cellular components related to Inclusion Body Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.1APP, DUSP6, MYH2, CHKB, RPS27A, GNE
2extracellular regionGO:0055767.9C4A, CXCL11, CXCL9, APP, APOE

Biological processes related to Inclusion Body Myositis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1T cell chemotaxisGO:0108189.7CXCL11, CXCR3
2nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358729.7RPS27A, APP
3regulation of type I interferon productionGO:0324799.5TREX1, RPS27A
4negative regulation of endothelial cell proliferationGO:0019379.5CXCR3, APOE
5positive regulation of cAMP metabolic processGO:0308169.3CXCR3, CXCL11, CXCL9
6positive regulation of cAMP-mediated signalingGO:0439509.3CXCR3, CXCL11, CXCL9
7positive regulation of release of sequestered calcium ion into cytosolGO:0512819.3CXCR3, CXCL11, CXCL9
8chemotaxisGO:0069359.1CXCL9, CXCL11, CXCR3
9inflammatory responseGO:0069548.6C4A, CXCR3, CXCL11, CXCL9
10innate immune responseGO:0450877.8APP, DUSP6, MYH2, RPS27A, C4A, TREX1

Molecular functions related to Inclusion Body Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CXCR3 chemokine receptor bindingGO:0482489.4CXCL11, CXCL9
2heparin bindingGO:0082018.7MSTN, CXCL11, APP, APOE

Products for genes affiliated with Inclusion Body Myositis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Inclusion Body Myositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet