MCID: INC002
MIFTS: 71

Inclusion Body Myositis malady

Genetic diseases, Rare diseases, Neuronal diseases, Metabolic diseases categories

Summaries for Inclusion Body Myositis

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NIH Rare Diseases:41 Inclusion body myopathy 2, also known as hereditary inclusion body myopathy (hibm), gne-related myopathy,  distal myopathy with rimmed vacuoles, and nonaka myopathy, is an inherited condition that primarily affects the skeletal muscles (the muscles that the body uses to move). this disorder is characterized by muscle weakness that appears in late adolescence or early adulthood and worsens over time. early symptoms typically develop in the 20s and 30s and may include difficulty running or walking, tripping, weakness in the index finger, and frequent loss of balance. inclusion body myopathy 2 is caused by mutations in the gne gene. the condition is inherited in an autosomal recessive manner. treatment is focused on managing individual symptoms. last updated: 1/13/2014

MalaCards based summary: Inclusion Body Myositis, also known as nonaka myopathy, is related to myositis and polymyositis, and has symptoms including muscle weakness, autoimmunity and amyotrophy. An important gene associated with Inclusion Body Myositis is MYH2 (myosin, heavy chain 2, skeletal muscle, adult), and among its related pathways are A-beta Uptake and Degradation and Alzheimers Disease Pathway. The drugs carisoprodol and chlorphenesin and the compounds metrifonate and 24s-hydroxy-cholesterol have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, t cells and brain, and related mouse phenotypes are renal/urinary system and growth/size/body.

Disease Ontology:9 A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.

NINDS:42 Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.

Genetics Home Reference:21 Inclusion body myopathy 2 is a condition that primarily affects skeletal muscles, which are muscles that the body uses for movement. This disorder causes muscle weakness that appears in late adolescence or early adulthood and worsens over time.

Wikipedia:63 Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive... more...

Aliases & Classifications for Inclusion Body Myositis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 42NINDS, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 38NCIt, 33MeSH, 27ICD9CM, 55SNOMED-CT, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet
See all sources

Inclusion Body Myositis, Aliases & Descriptions:

Name: Inclusion Body Myositis 9 41 42 11 47 60
Nonaka Myopathy 9 41 21 47 60
Distal Myopathy with Rimmed Vacuoles 9 41 21 47
Inclusion Body Myopathy Type 3 41 20 47 22
Ibm2 9 41 21 47
Inclusion Body Myopathy, Autosomal Recessive 41 21 60
Hereditary Inclusion Body Myopathy 9 41 21
Sporadic Inclusion Body Myositis 41 43 47
Inclusion Body Myopathy Type 2 41 47 22
Distal Myopathy, Nonaka Type 9 41 47
Inclusion Body Myopathy 2 9 41 21
Dmrv 41 21 47
Hibm 9 41 21
Hereditary Inclusion Body Myopathy - Joint Contractures - Ophthalmoplegia 41 47
Inclusion Body Myopathy, Quadriceps-Sparing 41 21
Hereditary Inclusion Body Myopathy Type 3 41 47
Hereditary Inclusion Body Myopathy Type 2 41 47
Quadriceps-Sparing Myopathy 41 47
Inclusion Body Myopathy 3 9 41
 
Rimmed Vacuole Myopathy 41 21
Gne Myopathy 41 47
Hibm2 41 47
Hibm3 41 47
Sibm 41 47
Ibm3 41 47
Qsm 41 21
Ibm 41 47
Myopathy with Congenital Joint Contractures, Ophthalmoplegia, and Rimmed Vacuoles 41
Inclusion Body Myopathy 3, Autosomal Dominant 60
Inclusion Body Myopathy, Autosomal Dominant 60
Inclusion Body Myopathy Autosomal Dominant 41
Inclusion Body Myopathy, Sporadic 60
Quadriceps Sparing Myopathy 41
Myositis Inclusion Body 43
Inflammatory Myopathies 42
Inflammatory Myopathy 41
Myositis 60
Ibm-3 9


Classifications:



Characteristics (Orphanet epidemiological data):

47
inclusion body myositis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: normal life expectancy
nonaka myopathy:
Inheritance: Autosomal recessive; Age of onset: Adult
inclusion body myopathy type 3:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal


External Ids:

Disease Ontology9 DOID:3429
NCIt38 C84786
MeSH33 D018979
ICD9CM27 359.71
SNOMED-CT55 72315009
Orphanet47 611, 602, 79091
ICD10 via Orphanet26 M60.8, G71.8
UMLS via Orphanet61 C0238190
MESH via Orphanet34 C536816

Related Diseases for Inclusion Body Myositis

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Diseases related to Inclusion Body Myositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1myositis32.5RPS27A, MSTN, CHKB, APP
2polymyositis31.7RPS27A, CHKB
3muscular dystrophy31.1GNE, MSTN, CHKB
4dementia31.0APP, APOE, RPS27A
5tauopathy30.7APP, RPS27A
6myopathy30.7GNE, APP, MYH2, MSTN, RPS27A, CHKB
7creutzfeldt-jakob disease30.6APP, RPS27A, APOE
8amyloidosis30.6RPS27A, APP, APOE
9alzheimer disease30.6CXCR3, RPS27A, APP, APOE, CHKB
10neuromuscular disease30.5GNE, CHKB, MSTN
11duchenne muscular dystrophy30.3MSTN, CHKB
12systemic lupus erythematosus30.3RPS27A, C4A, CXCR3
13dermatomyositis10.9
14dysphagia10.8
15nonaka myopathy10.7
16ophthalmoplegia10.6
17idiopathic myopathy10.5
18hereditary inclusion body myopathy type 410.5
19hereditary cerebral amyloid angiopathy10.5APP
20inflammatory myopathy with abundant macrophages10.5
21oculopharyngeal muscular dystrophy10.5
22hepatitis10.5
23hepatitis c10.5
24meningoencephalitis10.5APP
25interstitial lung disease10.5
26supranuclear palsy, progressive10.5APOE
27dementia, lewy body10.5APOE
28rheumatoid arthritis10.4
29hepatitis c virus10.4
30arthritis10.4
31leukemia10.4
32neuropathy10.4
33respiratory failure10.4
34myofibrillar myopathy10.4
35semantic dementia10.4RPS27A
36distal muscular dystrophy10.4
37atrioventricular block10.4
38restrictive cardiomyopathy10.4
39oculopharyngodistal myopathy10.4
40paget disease of bone10.4
41binswanger's disease10.4APOE, APP
42hemorrhage, intracerebral10.4APP, APOE
43common variable immunodeficiency10.4
44neuronitis10.4
45lupus erythematosus10.4
46peripheral neuropathy10.4
47sleep disorder10.4
48t-cell leukemia10.4
49blindness10.4
50alzheimer disease-210.4APOE, APP

Graphical network of the top 20 diseases related to Inclusion Body Myositis:



Diseases related to inclusion body myositis

Symptoms for Inclusion Body Myositis

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Symptoms:

 47 (show all 8)
  • muscle weakness/flaccidity
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • autoimmunity/autoimmune reaction/autoantibodies
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • areflexia/hyporeflexia
  • myalgia/muscular pain

HPO human phenotypes related to Inclusion Body Myositis:

(show all 18)
id Description Frequency HPO Source Accession
1 muscle weakness hallmark (90%) HP:0001324
2 autoimmunity hallmark (90%) HP:0002960
3 amyotrophy hallmark (90%) HP:0003202
4 emg abnormality hallmark (90%) HP:0003457
5 reduced tendon reflexes typical (50%) HP:0001315
6 feeding difficulties in infancy typical (50%) HP:0008872
7 myalgia occasional (7.5%) HP:0003326
8 autosomal dominant inheritance HP:0000006
9 hyporeflexia HP:0001265
10 abnormality of metabolism/homeostasis HP:0001939
11 dysphagia HP:0002015
12 distal muscle weakness HP:0002460
13 slow progression HP:0003677
14 proximal muscle weakness HP:0003701
15 sporadic HP:0003745
16 rimmed vacuoles HP:0003805
17 phenotypic variability HP:0003812
18 inflammatory myopathy HP:0009071

Drugs & Therapeutics for Inclusion Body Myositis

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Genetic Tests for Inclusion Body Myositis

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Genetic tests related to Inclusion Body Myositis:

id Genetic test Affiliating Genes
1 Inclusion Body Myopathy 320 22 MYH2
2 Inclusion Body Myopathy 222

Anatomical Context for Inclusion Body Myositis

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MalaCards organs/tissues related to Inclusion Body Myositis:

31
Skeletal muscle, T cells, Brain, Testes, Myeloid, Heart, Thyroid, Skin, Endothelial

Animal Models for Inclusion Body Myositis or affiliated genes

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MGI Mouse Phenotypes related to Inclusion Body Myositis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7GNE, APOE, CXCR3, MSTN, TREX1
2MP:00053788.1APOE, GNE, DUSP6, TREX1, MSTN, APP
3MP:00053858.1TREX1, MSTN, CXCR3, DUSP6, APOE, GNE
4MP:00053698.0CHKB, TREX1, DUSP6, APP, APOE, GNE
5MP:00053877.9TREX1, MSTN, CXCR3, DUSP6, APOE, APP
6MP:00053847.8TREX1, MSTN, CXCR3, DUSP6, APP, APOE
7MP:00107687.7APP, DUSP6, CXCR3, MSTN, GNE, TREX1
8MP:00053767.6APP, DUSP6, CHKB, CXCR3, GNE, APOE

Publications for Inclusion Body Myositis

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Articles related to Inclusion Body Myositis:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Mechanical ventilation weaning in inclusion body myositis: feasibility of isokinetic inspiratory muscle training as an adjunct therapy. (25147743)
2014
2
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
3
188th ENMC International Workshop: Inclusion Body Myositis, 2-4 December 2011, Naarden, The Netherlands. (24268584)
2013
4
Inclusion-body myositis associated with Alzheimer's disease. (23606855)
2013
5
The effect of anakinra, an IL1 receptor antagonist, in patients with sporadic inclusion body myositis (sIBM): a small pilot study. (23998706)
2013
6
Inclusion body myositis. (23250766)
2013
7
Inclusion body myositis associated with SjAPgren's syndrome. (23233115)
2013
8
TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]. (23023438)
2012
9
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study. (22554526)
2012
10
TWEAK in inclusion-body myositis muscle: possible pathogenic role of a cytokine inhibiting myogenesis. (22314077)
2012
11
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1I^-induced accumulation of I^-amyloid and cell death. (22436237)
2012
12
Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution? (20044785)
2012
13
Inclusion body myositis: diagnosis, pathogenesis, and treatment options. (21444018)
2011
14
TDP-43 plasma levels do not differentiate sporadic inclusion body myositis from other inflammatory myopathies. (21046407)
2010
15
Inclusion body myositis masquerading as amyotrophic lateral sclerosis. (21059520)
2010
16
Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)
2009
17
Detecting dysphagia in inclusion body myositis. (19603245)
2009
18
TDP-43: a reliable immunohistochemistry marker for inclusion body myositis? (19533631)
2009
19
Inclusion body myositis and HIV infection. (18641890)
2008
20
Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. (18258695)
2008
21
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)
2006
22
Inclusion body myositis: an underdiagnosed myopathy of older people. (16364943)
2006
23
Messenger RNA degradation may be inhibited in sporadic inclusion body myositis. (16087907)
2005
24
Steroid-responsive inclusion body myositis associated with endometrial cancer. (15789894)
2005
25
Sporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres. (15146016)
2004
26
119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. (15099594)
2004
27
Insulin-like growth factor I in inclusion-body myositis and human muscle cultures. (15217093)
2004
28
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
29
Inclusion body myositis: clonal expansions of muscle-infiltrating T cells persist over time. (12869141)
2003
30
Anti-PM-Scl antibodies in a patient with inclusion body myositis. (12869677)
2003
31
Primary SjAPgren's syndrome associated with inclusion body myositis. (11961175)
2002
32
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)
2001
33
Bcl-2, Bcl-x, and Bax expression by immunohistochemistry in inclusion body myositis: a study of 27 cases. (11570908)
2001
34
Prion codon 129 homozygosity and sporadic inclusion body myositis. (11468340)
2001
35
Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex. (10380695)
1999
36
Dermatomyositis. Diagnosis and evaluation of dermatomyositis, polymyositis, and inclusion-body myositis. (10599341)
1999
37
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis. (9596410)
1998
38
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
39
Intracellular phosphates in inclusion body myositis--a 31P magnetic resonance spectroscopy study. (9771678)
1998
40
T-cell heterogeneity in muscle lesions of inclusion body myositis. (9600712)
1998
41
Inflammatory myopathies [polymyositis, dermatomyositis, inclusion body myositis]. (9801848)
1998
42
Hepatitis C and inclusion body myositis. (8792712)
1996
43
Sporadic inclusion body myositis: counts of different types of abnormal fibers. (8572661)
1996
44
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
45
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
46
Inclusion body myositis: analysis of 32 cases. (1331441)
1992
47
Inclusion body myositis with abundant ring fibers. (1337419)
1992
48
Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis. (1321564)
1992
49
Familial inclusion body myositis among Kurdish-Iranian Jews. (1850594)
1991
50
Clinically unsuspected inclusion body myositis. (1850803)
1991

Variations for Inclusion Body Myositis

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Clinvar genetic disease variations for Inclusion Body Myositis:

6 (show all 14)
id Gene Variation Type Significance SNP ID Assembly Location
1MYH2NM_017534.5(MYH2): c.2116G> A (p.Glu706Lys)single nucleotide variantPathogenicrs121434589GRCh37Chr 17, 10438454: 10438454
2GNENM_001128227.2(GNE): c.620A> T (p.Asp207Val)single nucleotide variantPathogenicrs139425890GRCh37Chr 9, 36246117: 36246117
3GNENM_001128227.2(GNE): c.2228T> C (p.Met743Thr)single nucleotide variantPathogenicrs28937594GRCh37Chr 9, 36217396: 36217396
4GNENM_001128227.2(GNE): c.1820G> A (p.Gly607Glu)single nucleotide variantPathogenicrs121908625GRCh37Chr 9, 36219924: 36219924
5GNENM_001190383.1(GNE): c.1669G> A (p.Ala557Thr)single nucleotide variantPathogenicrs121908626GRCh37Chr 9, 36218222: 36218222
6GNENM_001190383.1(GNE): c.1864G> A (p.Val622Met)single nucleotide variantPathogenicrs121908627GRCh37Chr 9, 36217445: 36217445
7GNENM_001128227.2(GNE): c.1002T> A (p.Cys334Ter)single nucleotide variantPathogenicrs121908628GRCh37Chr 9, 36233990: 36233990
8GNENM_001128227.2(GNE): c.830G> A (p.Arg277Gln)single nucleotide variantPathogenicrs121908629GRCh37Chr 9, 36236861: 36236861
9GNENM_001128227.2(GNE): c.766G> A (p.Asp256Asn)single nucleotide variantPathogenicrs121908630GRCh37Chr 9, 36236925: 36236925
10GNENM_001128227.2(GNE): c.1472C> T (p.Ala491Val)single nucleotide variantPathogenicrs121908631GRCh37Chr 9, 36223402: 36223402
11GNENM_001128227.2(GNE): c.1807G> C (p.Val603Leu)single nucleotide variantPathogenicrs121908632GRCh37Chr 9, 36219937: 36219937
12GNENM_001128227.2(GNE): c.1000_1001delTGinsGT (p.Cys334Val)indelPathogenicrs121908633GRCh37Chr 9, 36233991: 36233992
13GNENM_001128227.2(GNE): c.1985C> T (p.Ala662Val)single nucleotide variantPathogenicrs62541771GRCh37Chr 9, 36218221: 36218221
14GNENM_001128227.2(GNE): c.604A> G (p.Met202Val)single nucleotide variantPathogenicrs121908634GRCh37Chr 9, 36246133: 36246133

Expression for genes affiliated with Inclusion Body Myositis

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Search GEO for disease gene expression data for Inclusion Body Myositis.

Pathways for genes affiliated with Inclusion Body Myositis

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Pathways related to Inclusion Body Myositis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8APP, APOE
29.8APP, APOE
39.5CXCL11, CXCR3
4
Show member pathways
9.2APP, RPS27A, TREX1
5
Show member pathways
9.1RPS27A, DUSP6, APP
6
Show member pathways
7.8APP, APOE, DUSP6, CXCL11, CXCR3, RPS27A

Compounds for genes affiliated with Inclusion Body Myositis

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Compounds related to Inclusion Body Myositis according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1metrifonate4310.2APOE, APP
224s-hydroxy-cholesterol4310.2APOE, APP
3thioflavin t4310.2APOE, APP
4edss4310.2APOE, CXCR3
5tacrine43 1211.2APP, APOE
6donepezil43 49 24 1213.2APP, APOE
7galantamine43 49 1212.1APOE, APP
8gemfibrozil28 43 1212.1CHKB, APOE
9rosuvastatin43 49 28 1213.0APOE, CHKB
10spec-t4310.0CHKB, APOE
11guanidine43 24 1211.9APOE, CHKB
12cysteamine43 24 1211.9APOE, RPS27A
13lovastatin43 49 59 28 1213.9APP, CHKB, APOE
14risperidone43 49 28 59 24 1214.9CHKB, APP
15simvastatin43 49 59 28 24 1214.8CHKB, APP, APOE
16bezafibrate43 28 1211.8CHKB, APOE
17thioflavine s439.7APP, RPS27A, APOE
18formate439.7RPS27A, APP, APOE
194-hydroxynonenal43 2410.7APOE, RPS27A, APP
20chloroquine43 2 49 28 1213.7APOE, APP, RPS27A
21guanidine hydrochloride439.7CHKB, RPS27A, APOE
22lactacystin439.7APP, APOE, RPS27A
23sodium dodecylsulfate439.7APOE, APP, RPS27A
24epinephrine43 24 1211.6APP, CHKB, RPS27A
25valine439.6APOE, RPS27A, APP
26n acetylcysteine439.5CHKB, RPS27A, APOE
27heparin43 28 24 1212.5CXCR3, CHKB, APOE, APP
28tamoxifen43 49 28 1212.5RPS27A, APOE, CHKB
29cholesterol43 28 24 1212.4APOE, APP, CXCR3, CHKB
30tacrolimus43 49 1211.4RPS27A, CXCR3, CHKB, APP
31aspirin43 49 28 2412.4RPS27A, APOE, APP, CHKB
32nmda43 2810.3APOE, APP, RPS27A
33glutamine439.3CHKB, RPS27A, APP, APOE
34dopamine43 28 24 1212.3APOE, APP, CHKB, RPS27A
35endotoxin439.3CHKB, CXCR3, C4A
36aspartate439.3RPS27A, CHKB, APP, APOE
37acetylcholine43 49 28 24 1213.2APOE, APP, RPS27A
38glutamate439.2CHKB, APP, APOE, RPS27A
39alanine439.1APOE, APP, CHKB, RPS27A
40creatinine439.1APOE, APP, CHKB, CXCR3, RPS27A
41vegf439.0CXCR3, APP, APOE, CHKB, RPS27A
42testosterone43 59 24 1212.0MSTN, RPS27A, APOE, APP, CHKB
43rapamycin438.9APOE, MSTN, RPS27A
44h2o2438.9APP, RPS27A, APOE, CHKB, DUSP6
45cysteine438.8CHKB, RPS27A, DUSP6, APP, APOE
46cyclosporin a43 28 5910.8RPS27A, CXCL11, CHKB, APP, APOE
47oxygen43 249.5DUSP6, MSTN, C4A, CXCR3, CHKB
48dexamethasone43 49 28 1211.4RPS27A, APP, CHKB, CXCL11, CXCR3, MSTN
49serine438.4CXCR3, C4A, APOE, RPS27A, APP
50arginine437.6RPS27A, CXCR3, CXCL11, CHKB, APP, APOE

GO Terms for genes affiliated with Inclusion Body Myositis

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Cellular components related to Inclusion Body Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.3RPS27A, CHKB, MYH2, DUSP6, APP, GNE

Biological processes related to Inclusion Body Myositis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of endothelial cell proliferationGO:00019379.8APOE, CXCR3
2positive regulation of cAMP metabolic processGO:00308169.7CXCR3, CXCL11
3T cell chemotaxisGO:00108189.7CXCR3, CXCL11
4positive regulation of cAMP-mediated signalingGO:00439509.7CXCL11, CXCR3
5regulation of type I interferon productionGO:00324799.6RPS27A, TREX1
6positive regulation of release of sequestered calcium ion into cytosolGO:00512819.6CXCR3, CXCL11
7nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:00358729.6APP, RPS27A
8stress-activated MAPK cascadeGO:00514039.4RPS27A, DUSP6
9inflammatory responseGO:00069548.4CXCL11, CXCR3, C4A
10innate immune responseGO:00450877.8RPS27A, MYH2, DUSP6, APP, TREX1, C4A

Molecular functions related to Inclusion Body Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082018.8MSTN, CXCL11, APP, APOE

Products for genes affiliated with Inclusion Body Myositis

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  • Antibodies
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  • Kits and Assays

Sources for Inclusion Body Myositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet