IBM
MCID: INC002
MIFTS: 77

Inclusion Body Myositis (IBM) malady

Genetic diseases, Rare diseases, Neuronal diseases, Muscle diseases categories

Summaries for Inclusion Body Myositis

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NIH Rare Diseases:44 Inclusion body myopathy 2, also known as hereditary inclusion body myopathy (hibm), gne-related myopathy,  distal myopathy with rimmed vacuoles, and nonaka myopathy, is an inherited condition that primarily affects the skeletal muscles (the muscles that the body uses to move). this disorder is characterized by muscle weakness that appears in late adolescence or early adulthood and worsens over time. early symptoms typically develop in the 20s and 30s and may include difficulty running or walking, tripping, weakness in the index finger, and frequent loss of balance. inclusion body myopathy 2 is caused by mutations in the gne gene. the condition is inherited in an autosomal recessive manner. treatment is focused on managing individual symptoms. last updated: 1/13/2014

MalaCards: Inclusion Body Myositis, also known as nonaka myopathy, is related to myositis and polymyositis, and has symptoms including areflexia/hyporeflexia, autoimmunity/autoimmune reaction/autoantibodies and myalgia/muscular pain. An important gene associated with Inclusion Body Myositis is GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase), and among its related pathways are A-beta Uptake and Degradation and Alzheimers Disease Pathway. The compounds metrifonate and 24s-hydroxy-cholesterol have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, t cells and brain, and related mouse phenotypes are renal/urinary system and growth/size/body.

Disease Ontology:9 A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.

NINDS:45 Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.

Wikipedia:66 Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive... more...

Description from OMIM:48 147421,605820,600737

Aliases & Classifications for Inclusion Body Myositis

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 11DISEASES, 50Orphanet, 48OMIM, 63UMLS, 22Genetics Home Reference, 10diseasecard, 23GTR, 46Novoseek, 36MeSH, 28ICD9CM, 41NCIt, 59SNOMED-CT, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Muscle diseases


Characteristics (Orphanet epidemiological data):

50
inclusion body myositis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood; Age of death: Normal
nonaka myopathy:
Inheritance: Autosomal recessive; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

inclusion body myositis 9 44 45 11 50 48 63
nonaka myopathy 9 10 44 23 22 48 46 50 63
distal myopathy with rimmed vacuoles 9 44 22 50
inclusion body myopathy 2 9 44 23 22
ibm2 9 44 22 50
inclusion body myopathy, autosomal recessive 44 22 48
hereditary inclusion body myopathy 9 44 22
hibm 9 44 22
dmrv 44 22 50
inclusion body myopathy, quadriceps-sparing 44 22
distal myopathy, nonaka type 9 50
rimmed vacuole myopathy 44 22
gne myopathy 44 50
ibm 44 50
qsm 44 22
inclusion body myopathy autosomal recessive 63
hereditary inclusion body myopathy type 2 50
inclusion body myopathy, sporadic 63
sporadic inclusion body myositis 50
inclusion body myopathy type 2 50
quadriceps sparing myopathy 44
quadriceps-sparing myopathy 50
myositis inclusion body 46
inflammatory myopathies 45
inflammatory myopathy 44
hibm2 50
sibm 50


External Ids:

Disease Ontology9 DOID:3429
MeSH36 D018979
ICD9CM28 359.71
NCIt41 C84786
SNOMED-CT59 72315009
SNOMED-CT via Orphanet60 72315009
ICD10 via Orphanet27 M60.8, G71.8
UMLS via Orphanet64 C0238190
MESH via Orphanet37 C536816

Related Diseases for Inclusion Body Myositis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Inclusion Body Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1myositis32.3RPS27A, CHKB, APP, MSTN
2polymyositis31.5RPS27A, CHKB
3myopathy31.3GNE, APP, RPS27A, CHKB, MSTN
4muscular dystrophy30.9MSTN, CHKB, GNE
5dementia30.8APOE, APP, RPS27A
6alzheimer's disease30.8APOE, APP, CXCR3, RPS27A, CHKB
7frontotemporal dementia30.7APOE, RPS27A, APP
8tauopathy30.4RPS27A, APP
9autoimmune thyroiditis30.4CHKB, CXCR3
10amyotrophic lateral sclerosis30.4APP, RPS27A, CHKB
11creutzfeldt-jakob disease30.4RPS27A, APP, APOE
12amyloidosis30.4APOE, RPS27A, APP
13parkinson's disease30.3APP, APOE, RPS27A, CHKB
14systemic lupus erythematosus30.3CXCR3, RPS27A, C4A
15neuromuscular disease30.3GNE, CHKB, MSTN
16sialuria30.1GNE
17duchenne muscular dystrophy30.0CHKB, MSTN
18dermatomyositis10.8
19dysphagia10.8
20inclusion body myopathy 310.6
21hepatitis c10.5
22oculopharyngeal muscular dystrophy10.5
23hepatitis10.5
24idiopathic myopathy10.5
25arthritis10.4
26neuropathy10.4
27respiratory failure10.4
28rheumatoid arthritis10.4
29myofibrillar myopathy10.4
30hepatitis c virus10.4
31atrioventricular block10.4
32distal muscular dystrophy10.4
33restrictive cardiomyopathy10.4
34oculopharyngodistal myopathy10.4
35hereditary inclusion body myopathy type 410.4
36interstitial lung disease10.4
37inflammatory myopathy with abundant macrophages10.4
38neuronitis10.3
39common variable immunodeficiency10.3
40leukemia10.3
41lupus erythematosus10.3
42peripheral neuropathy10.3
43t-cell leukemia10.3
44blindness10.3
45gne-related myopathy10.3
46hereditary myopathy with early respiratory failure10.3
47scleroderma10.2
48axonal neuropathy10.2
49lateral sclerosis10.2
50limb-girdle muscular dystrophy10.2

Graphical network of the top 20 diseases related to Inclusion Body Myositis:



Diseases related to inclusion body myositis

Symptoms for Inclusion Body Myositis

About this section
Sources:
48OMIM, 50Orphanet
See all sources

Symptoms by clinical synopsis from OMIM:

147421

Clinical features from OMIM:

147421,605820,600737

Symptoms:

50 (show all 8)
  • areflexia/hyporeflexia
  • autoimmunity/autoimmune reaction/autoantibodies
  • myalgia/muscular pain
  • abnormal emg/electromyogram/electropmyography
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • muscle weakness/flaccidity
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia

Drugs & Therapeutics for Inclusion Body Myositis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Inclusion Body Myositis

Drug clinical trials:

Search ClinicalTrials for Inclusion Body Myositis

Search NIH Clinical Center for Inclusion Body Myositis

Search CenterWatch for Inclusion Body Myositis

Genetic Tests for Inclusion Body Myositis

About this section
Sources:
23GTR
See all sources

Genetic tests related to Inclusion Body Myositis:

id Genetic test Affiliating Genes
1 Inclusion Body Myopathy 223
2 Nonaka Myopathy23

Anatomical Context for Inclusion Body Myositis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Inclusion Body Myositis:

34
Skeletal muscle, T cells, Brain, Testes, Myeloid, Endothelial, Thyroid, Heart, Skin

Animal Models for Inclusion Body Myositis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Inclusion Body Myositis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7GNE, APOE, CXCR3, MSTN, TREX1
2MP:00053788.1APOE, GNE, DUSP6, TREX1, MSTN, APP
3MP:00053858.1TREX1, MSTN, CXCR3, DUSP6, APOE, GNE
4MP:00053698.0CHKB, TREX1, DUSP6, APP, APOE, GNE
5MP:00053877.9TREX1, MSTN, CXCR3, DUSP6, APOE, APP
6MP:00053847.8TREX1, MSTN, CXCR3, DUSP6, APP, APOE
7MP:00107687.7APP, DUSP6, CXCR3, MSTN, GNE, TREX1
8MP:00053767.6APP, DUSP6, CHKB, CXCR3, GNE, APOE

Publications for Inclusion Body Myositis

About this section
Sources:
53PubMed
See all sources

Articles related to Inclusion Body Myositis:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
2
188th ENMC International Workshop: Inclusion Body Myositis, 2-4 December 2011, Naarden, The Netherlands. (24268584)
2013
3
Inclusion-body myositis associated with Alzheimer's disease. (23606855)
2013
4
The effect of anakinra, an IL1 receptor antagonist, in patients with sporadic inclusion body myositis (sIBM): a small pilot study. (23998706)
2013
5
Inclusion body myositis. (23250766)
2013
6
Inclusion body myositis associated with SjAPgren's syndrome. (23233115)
2013
7
TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]. (23023438)
2012
8
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study. (22554526)
2012
9
TWEAK in inclusion-body myositis muscle: possible pathogenic role of a cytokine inhibiting myogenesis. (22314077)
2012
10
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1I^-induced accumulation of I^-amyloid and cell death. (22436237)
2012
11
Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution? (20044785)
2012
12
Inclusion body myositis: diagnosis, pathogenesis, and treatment options. (21444018)
2011
13
TDP-43 plasma levels do not differentiate sporadic inclusion body myositis from other inflammatory myopathies. (21046407)
2010
14
Inclusion body myositis masquerading as amyotrophic lateral sclerosis. (21059520)
2010
15
Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)
2009
16
Detecting dysphagia in inclusion body myositis. (19603245)
2009
17
TDP-43: a reliable immunohistochemistry marker for inclusion body myositis? (19533631)
2009
18
Inclusion body myositis and HIV infection. (18641890)
2008
19
Interplay between inflammation and degeneration: using inclusion body myositis to study "neuroinflammation". (18626972)
2008
20
Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. (18258695)
2008
21
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)
2006
22
Inclusion body myositis: an underdiagnosed myopathy of older people. (16364943)
2006
23
Messenger RNA degradation may be inhibited in sporadic inclusion body myositis. (16087907)
2005
24
Steroid-responsive inclusion body myositis associated with endometrial cancer. (15789894)
2005
25
Sporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres. (15146016)
2004
26
119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. (15099594)
2004
27
Insulin-like growth factor I in inclusion-body myositis and human muscle cultures. (15217093)
2004
28
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
29
Inclusion body myositis: clonal expansions of muscle-infiltrating T cells persist over time. (12869141)
2003
30
Anti-PM-Scl antibodies in a patient with inclusion body myositis. (12869677)
2003
31
Primary SjAPgren's syndrome associated with inclusion body myositis. (11961175)
2002
32
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)
2001
33
Bcl-2, Bcl-x, and Bax expression by immunohistochemistry in inclusion body myositis: a study of 27 cases. (11570908)
2001
34
Prion codon 129 homozygosity and sporadic inclusion body myositis. (11468340)
2001
35
Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex. (10380695)
1999
36
Dermatomyositis. Diagnosis and evaluation of dermatomyositis, polymyositis, and inclusion-body myositis. (10599341)
1999
37
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis. (9596410)
1998
38
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
39
Intracellular phosphates in inclusion body myositis--a 31P magnetic resonance spectroscopy study. (9771678)
1998
40
T-cell heterogeneity in muscle lesions of inclusion body myositis. (9600712)
1998
41
Inflammatory myopathies [polymyositis, dermatomyositis, inclusion body myositis]. (9801848)
1998
42
Hepatitis C and inclusion body myositis. (8792712)
1996
43
Sporadic inclusion body myositis: counts of different types of abnormal fibers. (8572661)
1996
44
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
45
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
46
Inclusion body myositis: analysis of 32 cases. (1331441)
1992
47
Inclusion body myositis with abundant ring fibers. (1337419)
1992
48
Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis. (1321564)
1992
49
Familial inclusion body myositis among Kurdish-Iranian Jews. (1850594)
1991
50
Clinically unsuspected inclusion body myositis. (1850803)
1991

Variations for Inclusion Body Myositis

About this section
Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
See all sources

UniProtKB/Swiss-Prot genetic disease variations for Inclusion Body Myositis:

65 (show all 37)
id Symbol AA change Variation ID SNP ID
1GNEp.Pro36LeuVAR_017945
2GNEp.Ile200PheVAR_017946
3GNEp.Asp225AsnVAR_017947
4GNEp.Arg246GlnVAR_017948
5GNEp.Arg246TrpVAR_017949
6GNEp.Cys303ValVAR_017953
7GNEp.Asp378TyrVAR_017954
8GNEp.Asp378TyrVAR_017954
9GNEp.Ala460ValVAR_017955
10GNEp.Ala460ValVAR_017955
11GNEp.Ala524ValVAR_017956
12GNEp.Phe528CysVAR_017957
13GNEp.Ile557ThrVAR_017958
14GNEp.Val572LeuVAR_017959rs121908632
15GNEp.Val572LeuVAR_017959rs121908632
16GNEp.Gly576GluVAR_017960
17GNEp.Ile587ThrVAR_017961
18GNEp.Ala631ThrVAR_017962
19GNEp.Ala631ValVAR_017963
20GNEp.Ala631ValVAR_017963
21GNEp.Tyr675HisVAR_017964
22GNEp.Val696MetVAR_017965rs121908627
23GNEp.Met712ThrVAR_017966rs28937594
24GNEp.Pro27SerVAR_021771
25GNEp.His132GlnVAR_021772
26GNEp.Arg162CysVAR_021773
27GNEp.Met171ValVAR_021774
28GNEp.Asp176ValVAR_021775rs139425890
29GNEp.Arg177CysVAR_021776
30GNEp.Gly206SerVAR_021777
31GNEp.Val216AlaVAR_021778
32GNEp.Arg306GlnVAR_021779
33GNEp.Val331AlaVAR_021780
34GNEp.Ile472ThrVAR_021781
35GNEp.Asn519SerVAR_021782
36GNEp.Ala600ThrVAR_021783
37GNEp.Ala630ThrVAR_021784

Clinvar genetic disease variations for Inclusion Body Myositis:

1 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1GNENM_001128227.2(GNE): c.620A> T (p.Asp207Val)single nucleotide variantPathogenicrs139425890GRCh37Chr 9, 36246117: 36246117
2GNENM_001128227.2(GNE): c.2228T> C (p.Met743Thr)single nucleotide variantPathogenicrs28937594GRCh37Chr 9, 36217396: 36217396
3GNENM_001128227.2(GNE): c.1820G> A (p.Gly607Glu)single nucleotide variantPathogenicrs121908625GRCh37Chr 9, 36219924: 36219924
4GNENM_001190383.1(GNE): c.1669G> A (p.Ala557Thr)single nucleotide variantPathogenicrs121908626GRCh37Chr 9, 36218222: 36218222
5GNENM_001190383.1(GNE): c.1864G> A (p.Val622Met)single nucleotide variantPathogenicrs121908627GRCh37Chr 9, 36217445: 36217445
6GNENM_001128227.2(GNE): c.1002T> A (p.Cys334Ter)single nucleotide variantPathogenicrs121908628GRCh37Chr 9, 36233990: 36233990
7GNENM_001128227.2(GNE): c.830G> A (p.Arg277Gln)single nucleotide variantPathogenicrs121908629GRCh37Chr 9, 36236861: 36236861
8GNENM_001128227.2(GNE): c.766G> A (p.Asp256Asn)single nucleotide variantPathogenicrs121908630GRCh37Chr 9, 36236925: 36236925
9GNENM_001128227.2(GNE): c.1472C> T (p.Ala491Val)single nucleotide variantPathogenicrs121908631GRCh37Chr 9, 36223402: 36223402
10GNENM_001128227.2(GNE): c.1807G> C (p.Val603Leu)single nucleotide variantPathogenicrs121908632GRCh37Chr 9, 36219937: 36219937
11GNENM_001128227.2(GNE): c.1000_1001delTGinsGT (p.Cys334Val)indelPathogenicrs121908633GRCh37Chr 9, 36233991: 36233992
12GNENM_001128227.2(GNE): c.1985C> T (p.Ala662Val)single nucleotide variantPathogenicrs62541771GRCh37Chr 9, 36218221: 36218221
13GNENM_001128227.2(GNE): c.604A> G (p.Met202Val)single nucleotide variantPathogenicrs121908634GRCh37Chr 9, 36246133: 36246133

Expression for genes affiliated with Inclusion Body Myositis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Inclusion Body Myositis

Search GEO for disease gene expression data for Inclusion Body Myositis.

Pathways for genes affiliated with Inclusion Body Myositis

About this section
Sources:
51PathCards, 55R&D Systems, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 31KEGG
See all sources

Pathways related to Inclusion Body Myositis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8APP, APOE
29.8APP, APOE
39.5CXCL11, CXCR3
4
Show member pathways
9.2APP, RPS27A, TREX1
5
Show member pathways
9.1RPS27A, DUSP6, APP
6
Show member pathways
7.8APP, APOE, DUSP6, CXCL11, CXCR3, RPS27A

Compounds for genes affiliated with Inclusion Body Myositis

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Inclusion Body Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1metrifonate4610.2APOE, APP
224s-hydroxy-cholesterol4610.2APOE, APP
3thioflavin t4610.2APOE, APP
4edss4610.2APOE, CXCR3
5tacrine46 1211.2APP, APOE
6donepezil46 52 25 1213.2APP, APOE
7galantamine46 52 1212.1APOE, APP
8gemfibrozil30 46 1212.1CHKB, APOE
9rosuvastatin46 52 30 1213.0APOE, CHKB
10spec-t4610.0CHKB, APOE
11guanidine46 25 1211.9APOE, CHKB
12cysteamine46 25 1211.9APOE, RPS27A
13lovastatin46 52 62 30 1213.9APP, CHKB, APOE
14risperidone46 52 30 62 25 1214.9CHKB, APP
15simvastatin46 52 62 30 25 1214.8CHKB, APP, APOE
16bezafibrate46 30 1211.8CHKB, APOE
17thioflavine s469.7APP, RPS27A, APOE
18formate469.7RPS27A, APP, APOE
194-hydroxynonenal46 2510.7APOE, RPS27A, APP
20chloroquine46 3 52 30 1213.7APOE, APP, RPS27A
21guanidine hydrochloride469.7CHKB, RPS27A, APOE
22lactacystin469.7APP, APOE, RPS27A
23sodium dodecylsulfate469.7APOE, APP, RPS27A
24epinephrine46 25 1211.6APP, CHKB, RPS27A
25valine469.6APOE, RPS27A, APP
26n acetylcysteine469.5CHKB, RPS27A, APOE
27heparin46 30 25 1212.5CXCR3, CHKB, APOE, APP
28tamoxifen46 52 30 1212.5RPS27A, APOE, CHKB
29cholesterol46 30 25 1212.4APOE, APP, CXCR3, CHKB
30tacrolimus46 52 1211.4RPS27A, CXCR3, CHKB, APP
31aspirin46 52 30 2512.4RPS27A, APOE, APP, CHKB
32nmda46 3010.3APOE, APP, RPS27A
33glutamine469.3CHKB, RPS27A, APP, APOE
34dopamine46 30 25 1212.3APOE, APP, CHKB, RPS27A
35endotoxin469.3CHKB, CXCR3, C4A
36aspartate469.3RPS27A, CHKB, APP, APOE
37acetylcholine46 52 30 25 1213.2APOE, APP, RPS27A
38glutamate469.2CHKB, APP, APOE, RPS27A
39alanine469.1APOE, APP, CHKB, RPS27A
40creatinine469.1APOE, APP, CHKB, CXCR3, RPS27A
41vegf469.0CXCR3, APP, APOE, CHKB, RPS27A
42testosterone46 62 25 1212.0MSTN, RPS27A, APOE, APP, CHKB
43rapamycin468.9APOE, MSTN, RPS27A
44h2o2468.9APP, RPS27A, APOE, CHKB, DUSP6
45cysteine468.8CHKB, RPS27A, DUSP6, APP, APOE
46cyclosporin a46 30 6210.8RPS27A, CXCL11, CHKB, APP, APOE
47oxygen46 259.5DUSP6, MSTN, C4A, CXCR3, CHKB
48dexamethasone46 52 30 1211.4RPS27A, APP, CHKB, CXCL11, CXCR3, MSTN
49serine468.4CXCR3, C4A, APOE, RPS27A, APP
50arginine467.6RPS27A, CXCR3, CXCL11, CHKB, APP, APOE

GO Terms for genes affiliated with Inclusion Body Myositis

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Inclusion Body Myositis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of endothelial cell proliferationGO:0019379.8APOE, CXCR3
2positive regulation of cAMP metabolic processGO:0308169.7CXCL11, CXCR3
3T cell chemotaxisGO:0108189.7CXCL11, CXCR3
4regulation of type I interferon productionGO:0324799.6TREX1, RPS27A
5positive regulation of cAMP-mediated signalingGO:0439509.6CXCL11, CXCR3
6positive regulation of release of sequestered calcium ion into cytosolGO:0512819.6CXCL11, CXCR3
7nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358729.6APP, RPS27A
8stress-activated MAPK cascadeGO:0514039.4RPS27A, DUSP6
9inflammatory responseGO:0069548.4CXCL11, CXCR3, C4A
10innate immune responseGO:0450878.1C4A, TREX1, RPS27A, DUSP6, APP

Molecular functions related to Inclusion Body Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082018.8MSTN, CXCL11, APP, APOE

Products for genes affiliated with Inclusion Body Myositis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inclusion Body Myositis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet