MCID: INC002
MIFTS: 80

Inclusion Body Myositis malady

Genetic diseases, Rare diseases, Neuronal diseases, Metabolic diseases categories

Summaries for Inclusion Body Myositis

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NIH Rare Diseases:43 Inclusion body myopathy 2, also known as hereditary inclusion body myopathy (hibm), gne-related myopathy,  distal myopathy with rimmed vacuoles, and nonaka myopathy, is an inherited condition that primarily affects the skeletal muscles (the muscles that the body uses to move). this disorder is characterized by muscle weakness that appears in late adolescence or early adulthood and worsens over time. early symptoms typically develop in the 20s and 30s and may include difficulty running or walking, tripping, weakness in the index finger, and frequent loss of balance. inclusion body myopathy 2 is caused by mutations in the gne gene. the condition is inherited in an autosomal recessive manner. treatment is focused on managing individual symptoms. last updated: 1/13/2014

MalaCards based summary: Inclusion Body Myositis, also known as distal myopathy with rimmed vacuoles, is related to myositis and polymyositis, and has symptoms including muscle weakness, autoimmunity and amyotrophy. An important gene associated with Inclusion Body Myositis is MYH2 (myosin, heavy chain 2, skeletal muscle, adult), and among its related pathways are A-beta Uptake and Degradation and Alzheimers Disease Pathway. The drugs carisoprodol and chlorphenesin and the compounds metrifonate and 24s-hydroxy-cholesterol have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, t cells and brain, and related mouse phenotypes are renal/urinary system and growth/size/body.

Disease Ontology:10 A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.

NINDS:44 Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic, progressive muscle inflammation accompanied by muscle weakness.

Genetics Home Reference:23 Inclusion body myopathy 2 is a condition that primarily affects skeletal muscles, which are muscles that the body uses for movement. This disorder causes muscle weakness that appears in late adolescence or early adulthood and worsens over time.

Wikipedia:65 Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive... more...

Aliases & Classifications for Inclusion Body Myositis

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 23Genetics Home Reference, 49Orphanet, 62UMLS, 44NINDS, 12DISEASES, 24GTR, 22GeneTests, 45Novoseek, 40NCIt, 35MeSH, 29ICD9CM, 57SNOMED-CT, 28ICD10 via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 27ICD10
See all sources

Inclusion Body Myositis, Aliases & Descriptions:

Name: Inclusion Body Myositis 10 43 44 12 49 62
Distal Myopathy with Rimmed Vacuoles 10 43 23 49 62
Nonaka Myopathy 10 43 23 49 62
Hereditary Inclusion Body Myopathy 10 43 23 62
Inclusion Body Myopathy Type 3 43 22 49 24
Inclusion Body Myopathy 2 10 43 23 62
Dmrv 43 23 49 62
Ibm2 10 43 23 49
Sporadic Inclusion Body Myositis 43 45 49
Inclusion Body Myopathy Type 2 43 49 24
Distal Myopathy, Nonaka Type 10 43 49
Inclusion Body Myopathy 3 10 43 62
Rimmed Vacuole Myopathy 43 23 62
Hibm 10 43 23
Hereditary Inclusion Body Myopathy - Joint Contractures - Ophthalmoplegia 43 49
Inclusion Body Myopathy, Autosomal Recessive 43 23
Inclusion Body Myopathy, Quadriceps-Sparing 43 23
Hereditary Inclusion Body Myopathy Type 2 43 49
Hereditary Inclusion Body Myopathy Type 3 43 49
Quadriceps-Sparing Myopathy 43 49
 
Inflammatory Myopathy 43 62
Gne Myopathy 43 49
Hibm3 43 49
Hibm2 43 49
Ibm3 43 49
Sibm 43 49
Ibm 43 49
Qsm 43 23
Myopathy with Congenital Joint Contractures, Ophthalmoplegia, and Rimmed Vacuoles 43
Inclusion Body Myopathy 3, Autosomal Dominant 62
Inclusion Body Myopathy, Autosomal Dominant 62
Inclusion Body Myopathy Autosomal Recessive 62
Inclusion Body Myopathy Autosomal Dominant 43
Inclusion Body Myopathy, Sporadic 62
Quadriceps Sparing Myopathy 43
Myopathies, Inflammatory 62
Myositis Inclusion Body 45
Inflammatory Myopathies 44
Ibm-3 10


Classifications:



Characteristics (Orphanet epidemiological data):

49
inclusion body myositis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: normal life expectancy
distal myopathy with rimmed vacuoles:
Inheritance: Autosomal recessive; Age of onset: Adult
inclusion body myopathy type 3:
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal


External Ids:

Disease Ontology10 DOID:3429
NCIt40 C84786
MeSH35 D018979
ICD9CM29 359.71
Orphanet49 611, 602, 79091
SNOMED-CT57 72315009
ICD10 via Orphanet28 M60.8, G71.8
UMLS via Orphanet63 C0238190
MESH via Orphanet36 C536816
ICD1027 G72.4

Related Diseases for Inclusion Body Myositis

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Diseases related to Inclusion Body Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1myositis32.4RPS27A, MSTN, CHKB, APP
2polymyositis31.4RPS27A, CHKB
3myopathy31.4GNE, APP, MYH2, MSTN, RPS27A, CHKB
4muscular dystrophy30.9GNE, MSTN, CHKB
5dementia30.8APP, APOE, RPS27A
6alzheimer disease30.6CXCR3, RPS27A, APP, APOE, CHKB
7tauopathy30.4APP, RPS27A
8creutzfeldt-jakob disease30.3APP, RPS27A, APOE
9amyloidosis30.3RPS27A, APP, APOE
10neuromuscular disease30.3GNE, CHKB, MSTN
11systemic lupus erythematosus30.3RPS27A, C4A, CXCR3
12duchenne muscular dystrophy30.0MSTN, CHKB
13dermatomyositis10.9
14dysphagia10.8
15ophthalmoplegia10.6
16nonaka myopathy10.6
17inclusion body myopathy, autosomal recessive10.6
18idiopathic myopathy10.5
19oculopharyngeal muscular dystrophy10.5
20hepatitis10.5
21hepatitis c10.5
22interstitial lung disease10.5
23inflammatory myopathy with abundant macrophages10.5
24rheumatoid arthritis10.4
25hepatitis c virus10.4
26arthritis10.4
27leukemia10.4
28neuropathy10.4
29respiratory failure10.4
30myofibrillar myopathy10.4
31distal muscular dystrophy10.4
32atrioventricular block10.4
33restrictive cardiomyopathy10.4
34oculopharyngodistal myopathy10.4
35paget disease of bone10.4
36hereditary inclusion body myopathy type 410.4
37common variable immunodeficiency10.4
38neuronitis10.4
39lupus erythematosus10.4
40peripheral neuropathy10.4
41sleep disorder10.4
42t-cell leukemia10.4
43blindness10.4
44scleroderma10.3
45antisynthetase syndrome10.3
46inclusion body myopathy-310.3
47gne-related myopathy10.2
48focal myositis10.2
49welander distal myopathy10.2
50endometrial cancer10.2

Graphical network of the top 20 diseases related to Inclusion Body Myositis:



Diseases related to inclusion body myositis

Symptoms for Inclusion Body Myositis

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Symptoms:

 49 (show all 8)
  • muscle weakness/flaccidity
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • abnormal emg/electromyogram/electropmyography
  • autoimmunity/autoimmune reaction/autoantibodies
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • areflexia/hyporeflexia
  • myalgia/muscular pain

HPO human phenotypes related to Inclusion Body Myositis:

(show all 18)
id Description Frequency HPO Source Accession
1 muscle weakness hallmark (90%) HP:0001324
2 autoimmunity hallmark (90%) HP:0002960
3 amyotrophy hallmark (90%) HP:0003202
4 emg abnormality hallmark (90%) HP:0003457
5 reduced tendon reflexes typical (50%) HP:0001315
6 feeding difficulties in infancy typical (50%) HP:0008872
7 myalgia occasional (7.5%) HP:0003326
8 autosomal dominant inheritance HP:0000006
9 hyporeflexia HP:0001265
10 abnormality of metabolism/homeostasis HP:0001939
11 dysphagia HP:0002015
12 distal muscle weakness HP:0002460
13 slow progression HP:0003677
14 proximal muscle weakness HP:0003701
15 sporadic HP:0003745
16 rimmed vacuoles HP:0003805
17 phenotypic variability HP:0003812
18 inflammatory myopathy HP:0009071

Drugs & Therapeutics for Inclusion Body Myositis

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Genetic Tests for Inclusion Body Myositis

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Genetic tests related to Inclusion Body Myositis:

id Genetic test Affiliating Genes
1 Inclusion Body Myopathy 322 24 MYH2
2 Inclusion Body Myopathy 224

Anatomical Context for Inclusion Body Myositis

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MalaCards organs/tissues related to Inclusion Body Myositis:

33
Skeletal muscle, T cells, Brain, Testes, Myeloid, Heart, Thyroid, Skin, Endothelial

Animal Models for Inclusion Body Myositis or affiliated genes

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MGI Mouse Phenotypes related to Inclusion Body Myositis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7GNE, APOE, CXCR3, MSTN, TREX1
2MP:00053788.1TREX1, MSTN, DUSP6, APP, APOE, GNE
3MP:00053858.1GNE, APOE, DUSP6, CXCR3, MSTN, TREX1
4MP:00053698.0TREX1, GNE, APOE, APP, DUSP6, CHKB
5MP:00053877.9GNE, APOE, APP, DUSP6, CXCR3, MSTN
6MP:00053847.8APOE, APP, DUSP6, CXCR3, MSTN, TREX1
7MP:00107687.7GNE, APOE, APP, DUSP6, CXCR3, MSTN
8MP:00053767.6GNE, APOE, APP, DUSP6, CHKB, CXCR3

Publications for Inclusion Body Myositis

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Articles related to Inclusion Body Myositis:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Mechanical ventilation weaning in inclusion body myositis: feasibility of isokinetic inspiratory muscle training as an adjunct therapy. (25147743)
2014
2
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
3
188th ENMC International Workshop: Inclusion Body Myositis, 2-4 December 2011, Naarden, The Netherlands. (24268584)
2013
4
Inclusion-body myositis associated with Alzheimer's disease. (23606855)
2013
5
The effect of anakinra, an IL1 receptor antagonist, in patients with sporadic inclusion body myositis (sIBM): a small pilot study. (23998706)
2013
6
Inclusion body myositis. (23250766)
2013
7
Inclusion body myositis associated with SjAPgren's syndrome. (23233115)
2013
8
TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]. (23023438)
2012
9
Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study. (22554526)
2012
10
TWEAK in inclusion-body myositis muscle: possible pathogenic role of a cytokine inhibiting myogenesis. (22314077)
2012
11
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1I^-induced accumulation of I^-amyloid and cell death. (22436237)
2012
12
Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution? (20044785)
2012
13
Inclusion body myositis: diagnosis, pathogenesis, and treatment options. (21444018)
2011
14
TDP-43 plasma levels do not differentiate sporadic inclusion body myositis from other inflammatory myopathies. (21046407)
2010
15
Inclusion body myositis masquerading as amyotrophic lateral sclerosis. (21059520)
2010
16
Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. (19291799)
2009
17
Detecting dysphagia in inclusion body myositis. (19603245)
2009
18
TDP-43: a reliable immunohistochemistry marker for inclusion body myositis? (19533631)
2009
19
Inclusion body myositis and HIV infection. (18641890)
2008
20
Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. (18258695)
2008
21
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis. (17056255)
2006
22
Inclusion body myositis: an underdiagnosed myopathy of older people. (16364943)
2006
23
Messenger RNA degradation may be inhibited in sporadic inclusion body myositis. (16087907)
2005
24
Steroid-responsive inclusion body myositis associated with endometrial cancer. (15789894)
2005
25
Sporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres. (15146016)
2004
26
119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. (15099594)
2004
27
Insulin-like growth factor I in inclusion-body myositis and human muscle cultures. (15217093)
2004
28
Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. (15541003)
2004
29
Inclusion body myositis: clonal expansions of muscle-infiltrating T cells persist over time. (12869141)
2003
30
Anti-PM-Scl antibodies in a patient with inclusion body myositis. (12869677)
2003
31
Primary SjAPgren's syndrome associated with inclusion body myositis. (11961175)
2002
32
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy. (11303793)
2001
33
Bcl-2, Bcl-x, and Bax expression by immunohistochemistry in inclusion body myositis: a study of 27 cases. (11570908)
2001
34
Prion codon 129 homozygosity and sporadic inclusion body myositis. (11468340)
2001
35
Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex. (10380695)
1999
36
Dermatomyositis. Diagnosis and evaluation of dermatomyositis, polymyositis, and inclusion-body myositis. (10599341)
1999
37
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis. (9596410)
1998
38
Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy. (9827771)
1998
39
Intracellular phosphates in inclusion body myositis--a 31P magnetic resonance spectroscopy study. (9771678)
1998
40
T-cell heterogeneity in muscle lesions of inclusion body myositis. (9600712)
1998
41
Inflammatory myopathies [polymyositis, dermatomyositis, inclusion body myositis]. (9801848)
1998
42
Hepatitis C and inclusion body myositis. (8792712)
1996
43
Sporadic inclusion body myositis: counts of different types of abnormal fibers. (8572661)
1996
44
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (7478207)
1995
45
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
46
Inclusion body myositis: analysis of 32 cases. (1331441)
1992
47
Inclusion body myositis with abundant ring fibers. (1337419)
1992
48
Light and electron microscopic localization of beta-amyloid protein in muscle biopsies of patients with inclusion-body myositis. (1321564)
1992
49
Familial inclusion body myositis among Kurdish-Iranian Jews. (1850594)
1991
50
Clinically unsuspected inclusion body myositis. (1850803)
1991

Variations for Inclusion Body Myositis

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Clinvar genetic disease variations for Inclusion Body Myositis:

7 (show all 14)
id Gene Variation Type Significance SNP ID Assembly Location
1MYH2NM_017534.5(MYH2): c.2116G> A (p.Glu706Lys)single nucleotide variantPathogenicrs121434589GRCh37Chr 17, 10438454: 10438454
2GNENM_001128227.2(GNE): c.620A> T (p.Asp207Val)single nucleotide variantPathogenicrs139425890GRCh37Chr 9, 36246117: 36246117
3GNENM_001128227.2(GNE): c.2228T> C (p.Met743Thr)single nucleotide variantPathogenicrs28937594GRCh37Chr 9, 36217396: 36217396
4GNENM_001128227.2(GNE): c.1820G> A (p.Gly607Glu)single nucleotide variantPathogenicrs121908625GRCh37Chr 9, 36219924: 36219924
5GNENM_001190383.1(GNE): c.1669G> A (p.Ala557Thr)single nucleotide variantPathogenicrs121908626GRCh37Chr 9, 36218222: 36218222
6GNENM_001190383.1(GNE): c.1864G> A (p.Val622Met)single nucleotide variantPathogenicrs121908627GRCh37Chr 9, 36217445: 36217445
7GNENM_001128227.2(GNE): c.1002T> A (p.Cys334Ter)single nucleotide variantPathogenicrs121908628GRCh37Chr 9, 36233990: 36233990
8GNENM_001128227.2(GNE): c.830G> A (p.Arg277Gln)single nucleotide variantPathogenicrs121908629GRCh37Chr 9, 36236861: 36236861
9GNENM_001128227.2(GNE): c.766G> A (p.Asp256Asn)single nucleotide variantPathogenicrs121908630GRCh37Chr 9, 36236925: 36236925
10GNENM_001128227.2(GNE): c.1472C> T (p.Ala491Val)single nucleotide variantPathogenicrs121908631GRCh37Chr 9, 36223402: 36223402
11GNENM_001128227.2(GNE): c.1807G> C (p.Val603Leu)single nucleotide variantPathogenicrs121908632GRCh37Chr 9, 36219937: 36219937
12GNENM_001128227.2(GNE): c.1000_1001delTGinsGT (p.Cys334Val)indelPathogenicrs121908633GRCh37Chr 9, 36233991: 36233992
13GNENM_001128227.2(GNE): c.1985C> T (p.Ala662Val)single nucleotide variantPathogenicrs62541771GRCh37Chr 9, 36218221: 36218221
14GNENM_001128227.2(GNE): c.604A> G (p.Met202Val)single nucleotide variantPathogenicrs121908634GRCh37Chr 9, 36246133: 36246133

Expression for genes affiliated with Inclusion Body Myositis

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Search GEO for disease gene expression data for Inclusion Body Myositis.

Pathways for genes affiliated with Inclusion Body Myositis

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Pathways related to Inclusion Body Myositis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8APP, APOE
29.8APP, APOE
39.5CXCL11, CXCR3
4
Show member pathways
9.2APP, RPS27A, TREX1
5
Show member pathways
9.1RPS27A, DUSP6, APP
6
Show member pathways
7.8APP, APOE, DUSP6, CXCL11, CXCR3, RPS27A

Compounds for genes affiliated with Inclusion Body Myositis

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Compounds related to Inclusion Body Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1metrifonate4510.2APP, APOE
224s-hydroxy-cholesterol4510.2APP, APOE
3thioflavin t4510.2APP, APOE
4edss4510.2CXCR3, APOE
5tacrine45 1311.2APP, APOE
6donepezil45 51 26 1313.2APP, APOE
7galantamine45 51 1312.1APP, APOE
8gemfibrozil30 45 1312.1CHKB, APOE
9rosuvastatin45 51 30 1313.0APOE, CHKB
10spec-t4510.0APOE, CHKB
11guanidine45 26 1311.9APOE, CHKB
12cysteamine45 26 1311.9RPS27A, APOE
13lovastatin45 51 61 30 1313.9CHKB, APP, APOE
14risperidone45 51 30 61 26 1314.9CHKB, APP
15simvastatin45 51 61 30 26 1314.8CHKB, APP, APOE
16bezafibrate45 30 1311.8APOE, CHKB
17thioflavine s459.7RPS27A, APP, APOE
18formate459.7RPS27A, APP, APOE
194-hydroxynonenal45 2610.7APOE, APP, RPS27A
20chloroquine45 3 51 30 1313.7RPS27A, APP, APOE
21guanidine hydrochloride459.7RPS27A, CHKB, APOE
22lactacystin459.7APOE, APP, RPS27A
23sodium dodecylsulfate459.7RPS27A, APP, APOE
24epinephrine45 26 1311.6APP, CHKB, RPS27A
25valine459.6APOE, APP, RPS27A
26n acetylcysteine459.5RPS27A, CHKB, APOE
27heparin45 30 26 1312.5APOE, APP, CHKB, CXCR3
28tamoxifen45 51 30 1312.5RPS27A, CHKB, APOE
29cholesterol45 30 26 1312.4CXCR3, CHKB, APP, APOE
30tacrolimus45 51 1311.4APP, CHKB, CXCR3, RPS27A
31aspirin45 51 30 2612.4APOE, APP, CHKB, RPS27A
32nmda45 3010.3RPS27A, APP, APOE
33glutamine459.3APOE, APP, CHKB, RPS27A
34dopamine45 30 26 1312.3APOE, APP, CHKB, RPS27A
35endotoxin459.3CHKB, CXCR3, C4A
36aspartate459.3APOE, APP, CHKB, RPS27A
37acetylcholine45 51 30 26 1313.2RPS27A, APP, APOE
38glutamate459.2APOE, APP, CHKB, RPS27A
39alanine459.1APOE, APP, CHKB, RPS27A
40creatinine459.1RPS27A, CXCR3, CHKB, APP, APOE
41vegf459.0APOE, APP, CHKB, CXCR3, RPS27A
42testosterone45 61 26 1312.0APOE, APP, CHKB, MSTN, RPS27A
43rapamycin458.9RPS27A, MSTN, APOE
44h2o2458.9APOE, APP, DUSP6, CHKB, RPS27A
45cysteine458.8APOE, APP, DUSP6, CHKB, RPS27A
46cyclosporin a45 30 6110.8APOE, APP, CHKB, CXCL11, RPS27A
47oxygen45 269.5DUSP6, CHKB, CXCR3, MSTN, C4A
48dexamethasone45 51 30 1311.4APP, CHKB, CXCL11, CXCR3, MSTN, RPS27A
49serine458.4APOE, APP, CXCR3, RPS27A, C4A
50arginine457.6APOE, APP, CHKB, CXCL11, CXCR3, RPS27A

GO Terms for genes affiliated with Inclusion Body Myositis

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Cellular components related to Inclusion Body Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.3RPS27A, CHKB, MYH2, DUSP6, APP, GNE

Biological processes related to Inclusion Body Myositis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of endothelial cell proliferationGO:00019379.8CXCR3, APOE
2positive regulation of cAMP metabolic processGO:00308169.7CXCL11, CXCR3
3T cell chemotaxisGO:00108189.7CXCR3, CXCL11
4positive regulation of cAMP-mediated signalingGO:00439509.7CXCL11, CXCR3
5regulation of type I interferon productionGO:00324799.6RPS27A, TREX1
6positive regulation of release of sequestered calcium ion into cytosolGO:00512819.6CXCR3, CXCL11
7nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:00358729.6APP, RPS27A
8stress-activated MAPK cascadeGO:00514039.4RPS27A, DUSP6
9inflammatory responseGO:00069548.4C4A, CXCR3, CXCL11
10innate immune responseGO:00450877.8TREX1, C4A, RPS27A, MYH2, DUSP6, APP

Molecular functions related to Inclusion Body Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082018.8MSTN, CXCL11, APP, APOE

Products for genes affiliated with Inclusion Body Myositis

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Sources for Inclusion Body Myositis

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet