MCID: IND004
MIFTS: 33

Indeterminate Leprosy

Categories: Infectious diseases

Aliases & Classifications for Indeterminate Leprosy

MalaCards integrated aliases for Indeterminate Leprosy:

Name: Indeterminate Leprosy 12 14 69
Indeterminate Leprosy [group I] 12
Uncharacteristic Leprosy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11851
ICD10 33 A30.0
ICD9CM 35 030.2
SNOMED-CT 64 14386001
UMLS 69 C0021192

Summaries for Indeterminate Leprosy

Disease Ontology : 12 A leprosy that is an early form of the disease which causes one to a few hypopigmented or erythematous macules.

MalaCards based summary : Indeterminate Leprosy, also known as indeterminate leprosy [group i], is related to leprosy and brown's tendon sheath syndrome. An important gene associated with Indeterminate Leprosy is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Complement and coagulation cascades. The drugs Minocycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and renal/urinary system

Related Diseases for Indeterminate Leprosy

Diseases related to Indeterminate Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 leprosy 11.0
2 brown's tendon sheath syndrome 10.9 CD40LG MLLT1
3 erysipeloid 10.8 CD40LG SLC17A5
4 congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome 10.8 C4A C4B
5 hemochromatosis 10.8 C4A C4B
6 gout susceptibility 4 10.8 C4A C4B
7 fragile x syndrome type 2 10.7 CD40LG F8
8 plasmodium falciparum malaria 10.7 CD40LG HLA-B
9 alcoholic neuropathy 10.7 CD40LG CD79A
10 calloso-genital dysplasia 10.7 CD40LG CD79A
11 variola major 10.7 CD40LG CD79A
12 mu chain disease 10.7 CD40LG CD79A
13 rabies 10.7 CD40LG CD79A
14 familial retinoblastoma 10.7 CD40LG CD79A
15 anti-basement membrane glomerulonephritis 10.7 CD40LG CD79A
16 microinvasive cervical squamous cell carcinoma 10.7 CD40LG CD79A
17 fetal erythroblastosis 10.7 CD40LG CD79A
18 spinal canal and spinal cord meningioma 10.7 CD40LG CD79A
19 trichostrongyloidiasis 10.7 CD40LG CD79A
20 leukodystrophy 10.7 CD40LG CD79A
21 retinal microaneurysm 10.7 CD40LG CD79A
22 heart septal defect 10.7 CD40LG CD79A
23 cryptorchidism arachnodactyly mental retardation 10.7 CD40LG CD79A
24 acute kidney tubular necrosis 10.7 CD40LG CD79A
25 secretory meningioma 10.7 CD40LG CD79A
26 hodgkin's lymphoma, nodular sclerosis 10.7 CD40LG CD79A
27 imperforate oropharynx-costo vetebral anomalies 10.7 CD40LG CD79A
28 malignant otitis externa 10.6 CD40LG CD79A
29 transient hypogammaglobulinemia 10.6 CD40LG CD79A
30 benign epilepsy with centrotemporal spikes 10.6 CD40LG CD79A
31 tongue cancer 10.6 CD40LG CD79A
32 hydrops of gallbladder 10.6 CD40LG CD79A
33 gamma heavy chain disease 10.6 CD40LG CD79A
34 diabetic angiopathy 10.6 CD40LG CD79A
35 rosacea conjunctivitis 10.6 CD40LG CD79A
36 viral meningitis 10.6 CD40LG CD79A
37 heart fibrosarcoma 10.6 CD40LG CD79A
38 alopecia areata 10.6 CD40LG CD79A
39 kidney carcinoma in situ 10.6 CD40LG CD79A
40 acanthoma 10.6 HLA-B MICA SLC17A5
41 dumping syndrome 10.6 CD40LG CD79A
42 leiomyosarcoma 10.6 CD40LG CD79A
43 periarthritis 10.6 CD40LG CD79A
44 emphysema, congenital lobar 10.6 CD40LG HLA-B MICA
45 muscle tissue disease 10.6 CD40LG HLA-B MICA
46 generalized atherosclerosis 10.5 CD40LG CD79A
47 colonic benign neoplasm 10.5 CD40LG CD79A
48 cerebral neuroblastoma 10.5 CD40LG CD79A
49 muscle cancer 10.5 CD40LG CD68
50 gigantism 10.5 CD68 HLA-B

Graphical network of the top 20 diseases related to Indeterminate Leprosy:



Diseases related to Indeterminate Leprosy

Symptoms & Phenotypes for Indeterminate Leprosy

GenomeRNAi Phenotypes related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.15 HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.15 HBA1 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.15 C4B C4A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.15 MICA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.15 HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.15 C4A SLC17A5 C4B HBA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.15 HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.15 MICA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.15 SLC17A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.15 SLC17A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.15 SLC17A5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.15 C4B C4A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.15 HBA1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.15 HLA-B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.15 C4B C4A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.15 HLA-B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.15 C4B C4A HLA-B MICA SLC17A5
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.15 HBA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.15 HLA-B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.15 C4B C4A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.15 MICA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.15 SLC17A5
23 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.15 MICA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.15 C4B C4A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.15 HLA-B
26 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.15 HLA-B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.15 SLC17A5
28 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.15 C4A C4B
29 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.15 MICA

MGI Mouse Phenotypes related to Indeterminate Leprosy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.17 UCHL1 C4B CD40LG CD79A MLLT1 NPY

Drugs & Therapeutics for Indeterminate Leprosy

Drugs for Indeterminate Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
2 Anti-Bacterial Agents Phase 3
3 Anti-Infective Agents Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline

Search NIH Clinical Center for Indeterminate Leprosy

Genetic Tests for Indeterminate Leprosy

Anatomical Context for Indeterminate Leprosy

MalaCards organs/tissues related to Indeterminate Leprosy:

39
Skin, Lung

Publications for Indeterminate Leprosy

Articles related to Indeterminate Leprosy:

(show all 40)
id Title Authors Year
1
Dermal Dendrocytes FXIIIa+ Are Essential Antigen-Presenting Cells in Indeterminate Leprosy. ( 25365500 )
2014
2
Indeterminate leprosy and lepromatous index case: four cases in the same family. ( 24346893 )
2013
3
Inoculation indeterminate leprosy localised to a smallpox vaccination scar. ( 18309715 )
2007
4
Indeterminate leprosy in an infant. ( 17343225 )
2006
5
Ulnar nerve abscess and relapse in a patient with indeterminate leprosy 1 year after completion of multidrug therapy. ( 15995337 )
2005
6
Indeterminate leprosy, molluscum contagiosum and nevus depigmentosus. ( 11898470 )
2001
7
Delay in diagnosis: indeterminate leprosy presenting with rheumatic manifestations. ( 10689224 )
2000
8
Concomitant kala-azar, malaria, and progressive unstable indeterminate leprosy in an 8-year-old child. ( 9718914 )
1998
9
A case of lymphocytic vasculitis with infiltration of dermal nerves resembling indeterminate leprosy. ( 9614840 )
1998
10
Histopathologic evidence to show that indeterminate leprosy may be a primary lesion of the disease. ( 9465152 )
1997
11
A case of morphoea with dermal neuritis as in indeterminate leprosy. ( 9474518 )
1997
12
Enhancement in the histological diagnosis of indeterminate leprosy by demonstration of mycobacterial antigens. ( 8711981 )
1995
13
A case of secondary syphilis with a remarkable resemblance in histopathologic appearance to indeterminate leprosy. ( 7963917 )
1994
14
Indeterminate leprosy: a seroimmunological and histochemical evaluation. ( 8942147 )
1994
15
Agreement between histopathological results in clinically diagnosed cases of indeterminate leprosy in SALo Paulo, Brazil. ( 7863756 )
1994
16
Primary involvement of scrotal skin in indeterminate leprosy. ( 8463713 )
1993
17
Indeterminate leprosy: a therapeutic evaluation. ( 1607714 )
1992
18
Treated-cured indeterminate leprosy: a search for predictive histopathological and immunohistochemical parameters in skin biopsies taken from patients at admission and at clinical discharge. ( 1293916 )
1992
19
Indeterminate leprosy: histopathologic and histochemical predictive parameters involved in its possible change to paucibacillary or multibacillary leprosy. ( 2030308 )
1991
20
Camptodactyly simulating claw hand in a patient with indeterminate leprosy. ( 1783793 )
1991
21
Epidemiological significance of indeterminate leprosy--a hospital based study. ( 1919090 )
1991
22
Clinico-histopathological study of multidrug therapy in indeterminate leprosy. ( 2358708 )
1990
23
Demonstration of PGL I antigens in skin biopsies in indeterminate leprosy patients: comparison with serological anti PGL I levels. ( 2503967 )
1989
24
Demonstration of acid-fast bacilli in skin biopsies from indeterminate leprosy cases. ( 3068861 )
1988
25
CD1 positive epidermal Langerhans cells in indeterminate leprosy. ( 3051852 )
1988
26
Indeterminate leprosy: a clinical and histopathological evaluation. ( 3451924 )
1987
27
Indeterminate leprosy. A passing phase in the evolution of leprosy. ( 3312898 )
1987
28
Indeterminate leprosy. ( 3905636 )
1985
29
Histopathological evidence of indeterminate leprosy in apparently uninvolved skin of entire spectrum of leprosy. ( 6361381 )
1983
30
Indeterminate leprosy--a valid clinical concept. ( 6889581 )
1982
31
Histology of indeterminate leprosy. ( 6749705 )
1982
32
Should indeterminate leprosy ever be diagnosed? ( 7195888 )
1981
33
Indeterminate leprosy. ( 4424552 )
1974
34
Late lepromin reaction in untreated patients with indeterminate leprosy under 21 years old in Burma. ( 4267842 )
1973
35
Immune response to Mycobacterium leprae in indeterminate leprosy patients. ( 4209177 )
1973
36
Contribution to the study of borderline and indeterminate leprosy. ( 5324502 )
1965
37
8TH INTERNATIONAL CONGRESS OF LEPROLOGY, RIO DE JANEIRO, 1963. REPORT OF THE ROUND TABLE ON BORDERLINE AND INDETERMINATE LEPROSY. ( 14116688 )
1964
38
Indeterminate leprosy. ( 13658160 )
1959
39
Indeterminate leprosy acquired during military service; report of a case and review. ( 13393863 )
1957
40
Indeterminate leprosy: a new clinical variety. ( 14821242 )
1951

Variations for Indeterminate Leprosy

Expression for Indeterminate Leprosy

Search GEO for disease gene expression data for Indeterminate Leprosy.

Pathways for Indeterminate Leprosy

Pathways related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.2 CD68 CD79A IL3RA
2 11.07 C4A C4B F13A1 F8

GO Terms for Indeterminate Leprosy

Cellular components related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 C4A C4B CD40LG DEFB1 F13A1 F8
2 axon GO:0030424 9.62 C4A C4B TAC1 UCHL1
3 blood microparticle GO:0072562 9.46 C4A C4B F13A1 HBA1
4 extracellular space GO:0005615 9.28 C4A C4B CD40LG DEFB1 F8 HBA1
5 plasma membrane GO:0005886 10.03 C4A C4B CD40LG CD68 CD79A F8

Biological processes related to Indeterminate Leprosy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.43 NPS NPY TAC1
2 positive regulation of synaptic transmission, GABAergic GO:0032230 9.16 NPS TAC1
3 positive regulation of apoptotic cell clearance GO:2000427 8.96 C4A C4B
4 positive regulation of action potential GO:0045760 8.62 NPS TAC1

Sources for Indeterminate Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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