MCID: IND003
MIFTS: 24

Indolent Myeloma

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Indolent Myeloma

MalaCards integrated aliases for Indolent Myeloma:

Name: Indolent Myeloma 12 14 69
Indolent Multiple Myeloma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9550

Summaries for Indolent Myeloma

MalaCards based summary : Indolent Myeloma, also known as indolent multiple myeloma, is related to solitary osseous plasmacytoma and non-secretory myeloma, and has symptoms including bone pain An important gene associated with Indolent Myeloma is MYOM2 (Myomesin 2). The drugs Dexamethasone and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and bone marrow.

Related Diseases for Indolent Myeloma

Diseases related to Indolent Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 solitary osseous plasmacytoma 9.9 B2M MYOM2
2 non-secretory myeloma 9.9 B2M MYOM2
3 amyloid tumor 9.8 B2M MYOM2
4 monoclonal gammopathy of uncertain significance 9.8 B2M MYOM2
5 plasma cell neoplasm 9.8 B2M MYOM2
6 mature b-cell neoplasm 9.7 B2M MYOM2
7 lymphoma, non-hodgkin, familial 9.4 ANXA5 B2M
8 leukemia, chronic lymphocytic 9.3 ANXA5 B2M
9 myeloma, multiple 9.3 ANXA5 B2M MYOM2

Graphical network of the top 20 diseases related to Indolent Myeloma:



Diseases related to Indolent Myeloma

Symptoms & Phenotypes for Indolent Myeloma

UMLS symptoms related to Indolent Myeloma:


bone pain

Drugs & Therapeutics for Indolent Myeloma

Drugs for Indolent Myeloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
2
Zoledronic acid Approved Phase 2 118072-93-8 68740
3
Pamidronate Approved Phase 2 40391-99-9 4674
4
Lactulose Approved Phase 2 4618-18-2 11333
5
Bismuth Subsalicylate Approved, Vet_approved Phase 2 14882-18-9 53629521
6
Magnesium oxide Approved Phase 2 1309-48-4 14792
7
Bisacodyl Approved Phase 2 603-50-9
8
Magnesium Hydroxide Approved, Investigational Phase 2 1309-42-8
9
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
10 Dexamethasone acetate Phase 2,Phase 1 1177-87-3
11 glucocorticoids Phase 2,Phase 1
12
protease inhibitors Phase 2,Phase 1
13 Gastrointestinal Agents Phase 2,Phase 1
14 HIV Protease Inhibitors Phase 2,Phase 1
15 Hormone Antagonists Phase 2,Phase 1
16 Angiogenesis Inhibitors Phase 2,Phase 1
17 Hormones Phase 2,Phase 1
18 Diphosphonates Phase 2
19 Angiogenesis Modulating Agents Phase 2,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
21 Peripheral Nervous System Agents Phase 2,Phase 1
22 Anti-Bacterial Agents Phase 2,Phase 1
23 Antiemetics Phase 2,Phase 1
24 Anti-Infective Agents Phase 2,Phase 1
25 Immunosuppressive Agents Phase 2,Phase 1
26 Anti-Inflammatory Agents Phase 2,Phase 1
27 Interleukin 1 Receptor Antagonist Protein Phase 2,Phase 1
28 Antineoplastic Agents, Hormonal Phase 2,Phase 1
29 BB 1101 Phase 2,Phase 1
30 Autonomic Agents Phase 2,Phase 1
31 Bone Density Conservation Agents Phase 2
32 Antirheumatic Agents Phase 2,Phase 1
33 Siltuximab Approved, Investigational Phase 1 541502-14-1
34 Antibodies, Monoclonal Phase 1
35 Immunoglobulins Phase 1
36 Antibodies Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anakinra With or Without Dexamethasone in Treating Patients With Smoldering or Indolent Multiple Myeloma Completed NCT00635154 Phase 2 Dexamethasone acetate
2 Combination Bisphosphonate and Anti-Angiogenesis Therapy With Pamidronate and Thalidomide Completed NCT00083382 Phase 2 Pamidronate;Thalidomide;Zometa
3 Lenalidomide and Dexamethasone With or Without Anakinra in Treating Patients With Early Stage Multiple Myeloma Recruiting NCT02492750 Phase 1, Phase 2 Dexamethasone;Lenalidomide
4 A Study Evaluating the Effects of Siltuximab on the Heart in Patients With Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Indolent Multiple Myeloma Completed NCT01219010 Phase 1
5 Whole Body MRI Imaging in Multiple Myeloma at 3 Tesla MRI : Added Value of Diffusion Weighted Imaging Unknown status NCT01780766
6 Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM. Active, not recruiting NCT01079429

Search NIH Clinical Center for Indolent Myeloma

Genetic Tests for Indolent Myeloma

Anatomical Context for Indolent Myeloma

MalaCards organs/tissues related to Indolent Myeloma:

38
Bone, Heart, Bone Marrow

Publications for Indolent Myeloma

Articles related to Indolent Myeloma:

# Title Authors Year
1
Long-term results of single-agent thalidomide as initial therapy for asymptomatic (smoldering or indolent) myeloma. ( 20730790 )
2010
2
Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease. ( 19181642 )
2009
3
A smoldering/indolent myeloma with extensive abdominal presentation--case report. ( 16986300 )
2006
4
Pamidronate induces bone formation in patients with smouldering or indolent myeloma, with no significant anti-tumour effect. ( 12100153 )
2002
5
Smoldering, asymptomatic stage 1, and indolent myeloma. ( 12057049 )
2000
6
Coexistence of Polycythaemia Vera with Indolent Myeloma in the same Patient. ( 27406804 )
1997
7
Localized and indolent myeloma. ( 7407416 )
1980

Variations for Indolent Myeloma

Expression for Indolent Myeloma

Search GEO for disease gene expression data for Indolent Myeloma.

Pathways for Indolent Myeloma

GO Terms for Indolent Myeloma

Cellular components related to Indolent Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 ANXA5 B2M

Sources for Indolent Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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