ISM
MCID: IND002
MIFTS: 41

Indolent Systemic Mastocytosis (ISM) malady

Categories: Blood diseases, Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Indolent Systemic Mastocytosis

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 45NCIt, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Indolent Systemic Mastocytosis:

Name: Indolent Systemic Mastocytosis 11 54 13 68
 
Ism 11

Characteristics:

Orphanet epidemiological data:

54
indolent systemic mastocytosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:4660
ICD1030 D47.0
MeSH39 D034721
NCIt45 C9286
SNOMED-CT62 397356009, 70910003
Orphanet54 ORPHA98848
ICD10 via Orphanet31 D47.0
UMLS via Orphanet69 C0272203

Summaries for Indolent Systemic Mastocytosis

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MalaCards based summary: Indolent Systemic Mastocytosis, also known as ISM, is related to systemic mastocytosis and mastocytosis, and has symptoms including Array, Array and Array. An important gene associated with Indolent Systemic Mastocytosis is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways are Melanocyte Development and Pigmentation and Regulation of KIT signaling. Affiliated tissues include bone, skin and bone marrow.

Related Diseases for Indolent Systemic Mastocytosis

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Diseases related to Indolent Systemic Mastocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1systemic mastocytosis11.5
2mastocytosis10.6
3intracranial sinus thrombosis10.2KIT, KITLG
4hemangioma of peripheral nerve10.2KIT, KITLG
5high grade b-cell lymphoma with rearrangements of myc and bcl2 and/or bcl610.2KIT, KITLG
6cough variant asthma10.2KIT, KITLG
7invasive mole10.2KIT, PDGFRA
8dfnb110.2KIT, PDGFRA
9kahrizi syndrome10.2KIT, PDGFRA
10amaurosis congenita, cone-rod type, with congenital hypertrichosis10.2KIT, PDGFRA
11malignant epithelial mesothelioma10.2KIT, PDGFRA
12larynx leiomyosarcoma10.2KIT, PDGFRA
13priapism10.1KIT, KITLG
14extranodal nasal nk/t cell lymphoma10.1KIT, KITLG
15rectum leiomyoma10.1KIT, PDGFRA
16pustulosis palmaris et plantaris10.1KIT, PDGFRA
17epidermolysis bullosa simplex, recessive 110.1KIT, KITLG
18cerebral arterial disease10.1KIT, PDGFRA
19fragile x-associated tremor/ataxia syndrome10.1KIT, PDGFRA
20freemartinism10.1CD2, KIT
21kidney clear cell sarcoma10.1KIT, PDGFRA
22syndromic x-linked intellectual disability10.1KIT, KITLG
23hyperandrogenism due to cortisone reductase deficiency10.1KIT, PDGFRA
24fibrosarcoma10.1KIT, PDGFRA
25small intestinal sarcoma10.1KIT, PDGFRA
26osteoporosis10.1
27multifocal osteogenic sarcoma10.1KIT, PDGFRA
28prostate cancer, hereditary, x-linked 110.1KIT, KITLG
29c-p angle neurinoma10.1KIT, PDGFRA
30oral leukoedema10.0KIT, PDGFRA
31pericoronitis10.0HDC, KIT, KITLG
32acute dacryoadenitis10.0KIT, KITLG, PDGFRA
33brown-vialetto-van laere syndrome10.0KIT, PDGFRA
34erythrocytosis, somatic10.0KIT, KITLG, PDGFRA
35actinobacillosis10.0KIT, KITLG, PDGFRA
36gastrointestinal stromal tumor10.0KIT, KITLG, PDGFRA
37peroxisome biogenesis disorder 7a10.0KIT, KITLG, PDGFRA
38kala-azar 110.0KIT, KITLG, PDGFRA
39kidney rhabdoid cancer10.0CD2, KIT, KITLG
40meige syndrome10.0KIT, PDGFRA
41ganglioneuroma9.9CD2, KIT, PDGFRA
42urticaria pigmentosa9.9
43urticaria9.9
44isolated bone marrow mastocytosis9.9
45dentinogenesis imperfecta, shields type ii9.8CLEC11A, KIT, KITLG, PDGFRA
46olfactory nerve disease9.8CD2, KIT, KITLG, PDGFRA
47lymphoma9.8
48ileocolitis9.8
49diarrhea9.8
50cranioectodermal dysplasia 19.7CD2, KIT, KITLG

Graphical network of the top 20 diseases related to Indolent Systemic Mastocytosis:



Diseases related to indolent systemic mastocytosis

Symptoms & Phenotypes for Indolent Systemic Mastocytosis

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Human phenotypes related to Indolent Systemic Mastocytosis:

 54 64 (show all 13)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 behavioral abnormality64 54 Frequent (79-30%) HP:0000708
2 pruritus64 54 Very frequent (99-80%) HP:0000989
3 abnormality of skin pigmentation64 54 Very frequent (99-80%) HP:0001000
4 urticaria64 54 Very frequent (99-80%) HP:0001025
5 sudden cardiac death64 54 Very frequent (99-80%) HP:0001645
6 diarrhea64 54 Very frequent (99-80%) HP:0002014
7 nausea and vomiting64 54 Very frequent (99-80%) HP:0002017
8 abdominal pain64 54 Very frequent (99-80%) HP:0002027
9 headache64 54 Very frequent (99-80%) HP:0002315
10 abnormality of the gastric mucosa64 54 Occasional (29-5%) HP:0004295
11 reduced bone mineral density64 54 Occasional (29-5%) HP:0004349
12 impaired temperature sensation64 54 Very frequent (99-80%) HP:0010829
13 mastocytosis64 54 Very frequent (99-80%) HP:0100495

Drugs & Therapeutics for Indolent Systemic Mastocytosis

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Drugs for Indolent Systemic Mastocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1StaurosporineexperimentalPhase 24762996-74-1
24'-N-benzoylstaurosporinePhase 225
3Specific substance maruyamaPhase 215
4Protein Kinase InhibitorsPhase 23689
5Cromolyn SodiumPhase 217
6
Miconazoleapproved, investigational, vet_approved370622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
7
Mycophenolate mofetilapproved, investigational952128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
8
Fludarabineapproved115421679-14-1, 75607-67-930751
Synonyms:
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-F-ARAA
2-F-ara-A
2-Fluoro Ara-A
2-Fluoro-9-beta-D-arabinofuranosyladenine
2-fluoro ARA-A
21679-14-1
9-beta-D-Arabinofuranosyl-2-fluoroadenine
9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
AC1LCW8I
AC1Q51CF
C10H12FN5O4
CCRIS 3382
CHEMBL1568
CID657237
CPD000058874
D07966
EINECS 244-525-5
F-Ara-A
FAMP
FT-0082766
FaraA
Fludara
Fludara, Fludarabine
 
Fludarabina
Fludarabina [Spanish]
Fludarabine
Fludarabine (INN)
Fludarabine 5'-monophosphate
Fludarabine [INN]
Fludarabine monophosphate
Fludarabine phosphate
Fludarabinum
Fludarabinum [Latin]
Fludura
Fluradosa
Fluradosa (TN)
HSDB 6964
I14-4978
LS-15061
MLS000028687
NSC 118218
NSC 118218H
NSC-118218
S1491_Selleck
SAM002548956
SMR000058874
SQ Fludarabine
UNII-1X9VK9O1SC
UNII-P2K93U8740
ZINC04216238
9
Vidarabineapproved52124356-66-932326, 21704
Synonyms:
(+)-Cyclaradine
.beta.-Adenosine
.beta.-D-Adenosine
1odi
2-(6-AMINO-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
2946-52-3
2fqy
2gl0
30143-02-3
3080-29-3
3228-71-5
4005-33-8
46946-45-6
46969-16-8
524-69-6
5536-17-4
58-61-7
9-Arabinosyladenine
9-beta-D-Arabinofuranosyl-9H-purin-6-amine
9-beta-D-Arabinofuranosyl-adenine
9-beta-D-Arabinofuranosyladenine
9-beta-D-arabinofuranosyl-adenine
9-β-D-arabinofuranosyl-9H-purin-6-amine
9-β-D-arabinofuranosyladenine
A 9251
A0152
A4036_SIGMA
A4676_SIGMA
A5762_SIGMA
A9251_SIGMA
AC1L18OL
AC1L1U8O
AC1L2IWM
AC1L2SCM
AC1O4WIN
AC1O8PY7
AC1Q1ID3
AC1Q4Y1Z
AC1Q52XU
ADENOSINE, U.S.P.
ADN
AI3-52413
AI3-52821
AR-1H6029
ARA-A NSC 247519
Ade-Rib
Adenine Arabinoside
Adenine arabinoside
Adenine nucleoside
Adenine riboside
Adenine xyloside
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine arabinose
Adenosine-8-14C
Adensoine
Ambap5536-17-4
Ara A
Ara-A
Ara-ATP
Araadenosine
Arabinoside Adenine
Arabinoside adenine
Arabinosyl Adenine
Arabinosyl adenine
Arabinosyl-adenine
Arabinosyladenine
Arasena-A
Armes
Armes (TN)
BB_NC-0565
BPBio1_000898
BRN 0624881
BSPBio_000816
BSPBio_001796
BSPBio_002000
Bio1_000437
Bio1_000926
Bio1_001415
Boniton
C00212
CAS-5536-17-4
CCRIS 2557
CCRIS 3383
CHEBI:136932
CHEBI:16335
CHEBI:45327
CHEMBL1090
CHEMBL20247
CHEMBL477
CI 673
CI-673
CID102198
CID191
CID21704
CID60961
CID6420052
CID6713976
CPD000471872
Caswell No. 010B
D000241
D00045
D06298
DB00640
DivK1c_000191
EINECS 200-389-9
EINECS 217-911-6
EINECS 226-893-9
EU-0100123
FT-0082881
HMS1570I18
HMS1920A13
HMS1921K05
HMS2090F06
HMS2091G13
HMS2092C16
HMS500J13
HSDB 6514
 
I01-1121
IDI1_000191
KBio1_000191
KBio2_002418
KBio2_004986
KBio2_007554
KBio3_001296
KBio3_001500
KBioGR_001224
KBioSS_002424
L000094
LS-15059
LS-15085
Lopac0_000123
MEDR-640
MLS000069638
MLS000699527
MLS001066352
MLS001333133
MLS001333134
MLS002153227
MLS002153992
MolPort-001-785-903
MolPort-001-838-229
MolPort-003-666-308
Myocol
NCGC00016656-01
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NCGC00094579-01
NCGC00094579-02
NCGC00094579-03
NCGC00094579-04
NCGC00178869-01
NCGC00179417-01
NCI60_003823
NCI60_037192
NCIOpen2_003303
NCIOpen2_005376
NINDS_000191
NSC 247519
NSC 404241
NSC 627048
NSC 7359
NSC 7652
NSC-404241
NSC247519
NSC404241
NSC627048
NSC70422
NSC7359
NSC7652
NSC80832
NSC87676
NSC91041
Nucleocardyl
PDSP1_001036
PDSP2_001020
Pallacor
Polyadenosine
Polyriboadenosine
Prestwick0_000768
Prestwick1_000768
Prestwick2_000768
Prestwick3_000768
Prestwick_983
RAB
S1647_Selleck
S1784_Selleck
SAM002564191
SMP1_000312
SMR000058216
SMR000225041
SMR000471872
SMR001233326
SPBio_001194
SPBio_001491
SPBio_002755
SPECTRUM1500107
SPECTRUM1500609
SR 96225
SR-96225
STK361815
SUN-Y4001
Sandesin
Spectrum2_001257
Spectrum2_001336
Spectrum3_000288
Spectrum3_000580
Spectrum4_000782
Spectrum5_001429
Spectrum_001894
Spongoadenosine
TL8003749
UNII-3XQD2MEW34
UNII-K72T3FS567
USAF CB-10
V0098
VIRDARABINE
Vidarabin
Vidarabina
Vidarabina [DCIT]
Vidarabine
Vidarabine (JAN)
Vidarabine anhydrous
Vidarabinum
Vira ATM
Vira-A
Vira-A, Vidarabine
XA
Xylosyl A
Xylosyladenine
ZINC00970363
ZINC02169830
adenine-D-ribose
adenosine
alpha-Ara A
beta-Adenosine
beta-Ara A
beta-D-Adenosine
bmse000061
nchembio.143-comp9
nchembio.186-comp109
nchembio.64-comp4
nchembio706-5
10
Mycophenolic acidapproved95224280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
11
Cyclosporineapproved, investigational, vet_approved92279217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
12Dermatologic Agents5806
13Vidarabine Phosphate127
14Immunosuppressive Agents13086
15Antirheumatic Agents10956
16Antifungal Agents3696
17Antibiotics, Antitubercular7180
18Anti-Bacterial Agents11226
19Anti-Infective Agents22062
20Antimetabolites12054
21Antiviral Agents9967
22Antimetabolites, Antineoplastic7361
23Calcineurin Inhibitors1622

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase 3 Study to Compare Efficacy and Safety of Masitinib to Placebo in the Treatment of Patients With Smouldering Systemic, Indolent Systemic or Cutaneous Mastocytosis With HandicapUnknown statusNCT00814073Phase 3
2Study on Mastocytosis for Rupatadine TreatmentCompletedNCT01481909Phase 2, Phase 3
3Midostaurin in Indolent Systemic MastocytosisUnknown statusNCT01920204Phase 2
4Treatment of Indolent Systemic Mastocytosis With PA101CompletedNCT02478957Phase 2
5Efficacy of AB1010 in Patients With Systemic Indolent MastocytosisCompletedNCT00831974Phase 2
6A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK002RecruitingNCT02808793Phase 1
7Patient-Reported Outcome Questionnaire for Systemic MastocytosisCompletedNCT02380222
8Mast Cell Connect: A Registry for Patients With MastocytosisRecruitingNCT02620254
9Diagnostic Value of Bone Marrow Tryptase in Systemic MastocytosisRecruitingNCT02441166
10Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic MalignanciesActive, not recruitingNCT00014235

Search NIH Clinical Center for Indolent Systemic Mastocytosis

Genetic Tests for Indolent Systemic Mastocytosis

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Anatomical Context for Indolent Systemic Mastocytosis

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MalaCards organs/tissues related to Indolent Systemic Mastocytosis:

36
Bone, Skin, Bone marrow, Colon

Publications for Indolent Systemic Mastocytosis

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Articles related to Indolent Systemic Mastocytosis:

(show all 44)
idTitleAuthorsYear
1
Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study. (28069279)
2017
2
Longitudinal Evaluation of Bone Mineral Density and Bone Metabolism Markers in Patients with Indolent Systemic Mastocytosis Without Osteoporosis. (27743017)
2017
3
Response of patients with indolent systemic mastocytosis to tamoxifen citrate. (26612479)
2016
4
KIT D816V-mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progression. (26622064)
2016
5
Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression. (26153655)
2015
6
Response to celecoxib in a patient with indolent systemic mastocytosis presenting with intractable diarrhea. (26505934)
2015
7
Therapeutic challenge during the long-term follow-up of a patient with indolent systemic mastocytosis with extensive cutaneous involvement. (26004600)
2015
8
The impact of sensitive KIT D816V detection on recognition of indolent Systemic Mastocytosis. (25582384)
2015
9
Sustained improvement in urticaria pigmentosa and pruritus in a case of indolent systemic mastocytosis treated with cladribine. (25515765)
2015
10
MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis. (25542754)
2014
11
Delayed diagnosis of adult indolent systemic mastocytosis. (25386326)
2014
12
Predictors of new fragility fractures after diagnosis of indolent systemic mastocytosis. (24985401)
2014
13
Endoscopic findings of indolent systemic mastocytosis involving the colon. (25526423)
2014
14
Indolent systemic mastocytosis in a patient with ileocolitis. (24975749)
2014
15
Serum levels of bone cytokines in indolent systemic mastocytosis associated with osteopenia or osteoporosis. (24439083)
2014
16
KIT D816V mutation burden does not correlate to clinical manifestations of indolent systemic mastocytosis. (23587333)
2013
17
Prevalence of indolent systemic mastocytosis in a Dutch region. (23219169)
2013
18
Serum tryptase correlates with the KIT D816V mutation burden in adults with indolent systemic mastocytosis. (23621866)
2013
19
Indolent systemic mastocytosis: a case and review of the current available treatment options. (24011312)
2013
20
Serum levels of bone cytokines are increased in indolent systemic mastocytosis associated with osteopenia or osteoporosis. (23910691)
2013
21
Omalizumab Induced Remission of Idiopathic Anaphylaxis in a Patient Suffering from Indolent Systemic Mastocytosis. (24162824)
2013
22
Role of imatinib in the treatment of pediatric onset indolent systemic mastocytosis: a case report. (23659595)
2013
23
Indolent systemic mastocytosis limited to the bone: a case report and review of the literature. (23903270)
2013
24
Serum tryptase monitoring in indolent systemic mastocytosis: association with disease features and patient outcome. (24155887)
2013
25
Indolent systemic mastocytosis: is there a reliable radiographic pattern? (22281758)
2012
26
High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis. (22229787)
2012
27
Circulating KIT D816V mutation-positive non-mast cells in peripheral blood are characteristic of indolent systemic mastocytosis. (22469616)
2012
28
Indolent systemic mastocytosis treated with narrow-band UVB phototherapy: study of five cases. (21564325)
2012
29
Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions. (22435702)
2012
30
Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis. (21193416)
2011
31
Indolent systemic mastocytosis without skin involvement vs. isolated bone marrow mastocytosis. (21454873)
2011
32
Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis. (21143240)
2011
33
Gene expression profile, pathways, and transcriptional system regulation in indolent systemic mastocytosis. (21208217)
2011
34
Bone mineral density, bone turnover markers and fractures in patients with indolent systemic mastocytosis. (21782049)
2011
35
Indolent systemic mastocytosis. (20684189)
2010
36
Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. (19541349)
2009
37
High omalizumab dose controls recurrent reactions to venom immunotherapy in indolent systemic mastocytosis. (18269681)
2008
38
Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis. (18177694)
2008
39
Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease. (18448146)
2008
40
Use of a doula for labor coaching in a patient with indolent systemic mastocytosis in pregnancy. (16449169)
2006
41
Indolent systemic mastocytosis as the cause of a long history of unexplained hypotensive episodes. (16929885)
2006
42
Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes. (15722637)
2005
43
Evolution of urticaria pigmentosa into indolent systemic mastocytosis: abnormal immunophenotype of mast cells without evidence of c-kit mutation ASP-816-VAL. (12688351)
2003
44
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. (9440541)
1997

Variations for Indolent Systemic Mastocytosis

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Expression for genes affiliated with Indolent Systemic Mastocytosis

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Search GEO for disease gene expression data for Indolent Systemic Mastocytosis.

Pathways for genes affiliated with Indolent Systemic Mastocytosis

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Pathways related to Indolent Systemic Mastocytosis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.7KIT, KITLG
29.7KIT, KITLG
39.7KIT, KITLG
49.7KIT, KITLG
59.6KIT, PDGFRA
69.6KIT, PDGFRA
7
Show member pathways
9.6KIT, PDGFRA
89.2KIT, KITLG, PDGFRA
9
Show member pathways
9.2KIT, KITLG, PDGFRA
10
Show member pathways
9.2KIT, KITLG, PDGFRA
11
Show member pathways
9.2KIT, KITLG, PDGFRA
129.2KIT, KITLG, PDGFRA
139.2KIT, KITLG, PDGFRA
149.1CLEC11A, KITLG, PDGFRA
159.1CD2, KIT, KITLG
169.1CD2, KIT, KITLG
179.1CD2, KIT, KITLG
18
Show member pathways
8.7CLEC11A, KIT, KITLG, PDGFRA
19
Show member pathways
8.7CLEC11A, KIT, KITLG, PDGFRA
20
Show member pathways
8.7CLEC11A, KIT, KITLG, PDGFRA
21
Show member pathways
8.7CLEC11A, KIT, KITLG, PDGFRA
22
Show member pathways
8.1CD2, CLEC11A, KIT, KITLG, PDGFRA
23
Show member pathways
8.1CD2, CLEC11A, KIT, KITLG, PDGFRA
24
Show member pathways
8.1CD2, CLEC11A, KIT, KITLG, PDGFRA

GO Terms for genes affiliated with Indolent Systemic Mastocytosis

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Cellular components related to Indolent Systemic Mastocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:000989810.1CD2, KIT
2external side of plasma membraneGO:00098979.0CD2, KIT, PDGFRA

Biological processes related to Indolent Systemic Mastocytosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:003523410.4KIT, KITLG
2embryonic hemopoiesisGO:003516210.4KIT, KITLG
3ovarian follicle developmentGO:000154110.4KIT, KITLG
4cell chemotaxisGO:006032610.3KIT, PDGFRA
5positive regulation of MAP kinase activityGO:004340610.3KIT, KITLG
6positive regulation of DNA replicationGO:004574010.1KITLG, PDGFRA
7positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.1KIT, PDGFRA
8positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.1KIT, PDGFRA
9positive regulation of phospholipase C activityGO:001086310.1KIT, PDGFRA
10MAPK cascadeGO:00001659.9KIT, KITLG, PDGFRA
11phosphatidylinositol phosphorylationGO:00468549.9KIT, KITLG, PDGFRA
12phosphatidylinositol-mediated signalingGO:00480159.9KIT, KITLG, PDGFRA
13regulation of phosphatidylinositol 3-kinase signalingGO:00140669.2KIT, KITLG, PDGFRA
14positive regulation of cell proliferationGO:00082848.5CLEC11A, KIT, KITLG, MVD, PDGFRA

Molecular functions related to Indolent Systemic Mastocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.9KIT, KITLG, PDGFRA
2carboxy-lyase activityGO:00168319.8HDC, MVD
3Ras guanyl-nucleotide exchange factor activityGO:00050889.6KIT, KITLG, PDGFRA
4transmembrane receptor protein tyrosine kinase activityGO:00047149.6KIT, PDGFRA
5protein homodimerization activityGO:00428038.7CD2, KIT, MVD, PDGFRA

Sources for Indolent Systemic Mastocytosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet