MCID: IND002
MIFTS: 39

Indolent Systemic Mastocytosis malady

Blood diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Indolent Systemic Mastocytosis

About this section
Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Indolent Systemic Mastocytosis:

Name: Indolent Systemic Mastocytosis 10 12 51 65
Mastocytosis, Systemic 36
 
Ism 10


Classifications:



Characteristics (Orphanet epidemiological data):

51
indolent systemic mastocytosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages


External Ids:

Disease Ontology10 DOID:4660
MeSH36 D034721
NCIt42 C9286
SNOMED-CT59 70910003, 397356009
Orphanet51 98848
ICD10 via Orphanet28 D47.0
UMLS via Orphanet66 C0272203

Summaries for Indolent Systemic Mastocytosis

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MalaCards based summary: Indolent Systemic Mastocytosis, also known as mastocytosis, systemic, is related to connective tissue disease and systemic mastocytosis, and has symptoms including pruritus, abnormality of skin pigmentation and urticaria. An important gene associated with Indolent Systemic Mastocytosis is KIT (V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog), and among its related pathways are Regulation of KIT signaling and Melanocyte Development and Pigmentation. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are pigmentation and hematopoietic system.

Related Diseases for Indolent Systemic Mastocytosis

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Diseases related to Indolent Systemic Mastocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1connective tissue disease30.5KIT, PDGFRA
2systemic mastocytosis11.0
3mastocytosis11.0
4osteoporosis10.4
5mast cell disease10.4
6urticaria pigmentosa10.4
7connective tissue benign neoplasm10.4
8connective tissue cancer10.4
9urticaria10.4
10isolated bone marrow mastocytosis10.4
11thrombocytopenic purpura, autoimmune10.2
12leukemia10.2
13thrombocytopenia due to platelet alloimmunization10.2
14mast-cell leukemia10.2
15ileocolitis10.2
16aggressive systemic mastocytosis10.2
17diarrhea10.2
18mast cell neoplasm10.2
19space motion sickness10.2KIT, KITLG
20neurohypophysis granular cell tumor10.2KIT, KITLG
21wheat allergic reaction10.2KIT, KITLG
22anterior corneal pigmentation10.2KIT, KITLG
23exencephaly10.2KIT, KITLG
24cortical blindness10.2KIT, KITLG
25renal tubular acidosis10.1KIT, KITLG
26tracheomalacia10.1KIT, KITLG
27extraneural perineurioma10.1KIT, PDGFRA
28medulloepithelioma10.1KIT, PDGFRA
29hypereosinophilic syndrome, idiopathic, resistant to imatinib10.1KIT, PDGFRA
30urinary bladder small cell neuroendocrine carcinoma10.1KIT, PDGFRA
31prostate leiomyosarcoma10.1KIT, PDGFRA
32pulmonary venous return anomaly10.1KIT, PDGFRA
33cryptococcosis10.1KIT, PDGFRA
34heart septal defect10.1KIT, PDGFRA
35carnitine palmitoyltransferase i deficiency , muscle10.1KIT, PDGFRA
36desmoplastic infantile astrocytoma10.1KIT, PDGFRA
37periosteal osteogenic sarcoma10.1KIT, PDGFRA
38mesenchymal chondrosarcoma10.1KIT, PDGFRA
39osteogenesis imperfecta - retinopathy - seizures - intellectual disability10.1KIT, PDGFRA
40hypergonadotropic ovarian failure, familial or sporadic10.1KIT, PDGFRA
41cecal benign neoplasm10.1KIT, PDGFRA
42oral hairy leukoplakia10.1KIT, PDGFRA
43microphthalmia, syndromic 410.1KIT, KITLG
44lacrimal gland mucoepidermoid carcinoma10.1KIT, PDGFRA
45neuritis10.0KIT, PDGFRA
46benign hypertensive renal disease10.0KIT, PDGFRA
47gestational choriocarcinoma10.0KIT, KITLG
48silent myocardial infarction10.0KIT, PDGFRA
49leukodystrophy10.0KIT, PDGFRA
50brachyolmia10.0KIT, PDGFRA

Graphical network of the top 20 diseases related to Indolent Systemic Mastocytosis:



Diseases related to indolent systemic mastocytosis

Symptoms for Indolent Systemic Mastocytosis

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Symptoms:

 51 (show all 13)
  • urticaria
  • pruritus/itching
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • facial pain/cephalalgia/migraine
  • mastocytosis
  • hot flushes/sensation of cold
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets

HPO human phenotypes related to Indolent Systemic Mastocytosis:

(show all 13)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 abnormality of skin pigmentation hallmark (90%) HP:0001000
3 urticaria hallmark (90%) HP:0001025
4 sudden cardiac death hallmark (90%) HP:0001645
5 diarrhea hallmark (90%) HP:0002014
6 nausea and vomiting hallmark (90%) HP:0002017
7 abdominal pain hallmark (90%) HP:0002027
8 migraine hallmark (90%) HP:0002076
9 impaired temperature sensation hallmark (90%) HP:0010829
10 mastocytosis hallmark (90%) HP:0100495
11 behavioral abnormality typical (50%) HP:0000708
12 abnormality of the gastric mucosa occasional (7.5%) HP:0004295
13 reduced bone mineral density occasional (7.5%) HP:0004349

Drugs & Therapeutics for Indolent Systemic Mastocytosis

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Drugs for Indolent Systemic Mastocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1StaurosporineexperimentalPhase 21862996-74-144120114
2Cromolyn SodiumPhase 215
34'-N-benzoylstaurosporinePhase 220
4
Mycophenolate mofetilapproved, investigational864128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate Mofetil
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
5
Mycophenolic acidapproved86424280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
Melbex
 
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolic Acid
Mycophenolsaeure
Myfortic
6
Miconazoleapproved, investigational291222916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
7
Fludarabineapproved100821679-14-1, 75607-67-930751
Synonyms:
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-F-ara-A
2-Fluoro Ara-A
2-Fluoro-9-beta-D-arabinofuranosyladenine
2-Fluoro-ara AMP
2-Fluoroadenine arabinoside 5'-monophosphate
21679-14-1
2F-Ara-AMP
9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate
9-beta-D-Arabinofuranosyl-2-fluoroadenine
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate
9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
AC1LCW8I
AC1Q51CF
C10H12FN5O4
CCRIS 3382
CHEMBL1568
CID657237
CPD000058874
D07966
EINECS 244-525-5
F-Ara-A
FAMP
FT-0082766
FaraA
Fludara
 
Fludara, Fludarabine
Fludarabina
Fludarabina [Spanish]
Fludarabine
Fludarabine (INN)
Fludarabine 5'-monophosphate
Fludarabine Phosphate
Fludarabine [INN]
Fludarabine monophosphate
Fludarabine phosphate
Fludarabinum
Fludarabinum [Latin]
Fludura
Fluradosa
Fluradosa (TN)
HSDB 6964
I14-4978
LS-15061
MLS000028687
NSC 118218
NSC 118218H
NSC-118218
Oforta
S1491_Selleck
SAM002548956
SMR000058874
SQ Fludarabine
UNII-1X9VK9O1SC
UNII-P2K93U8740
ZINC04216238
8
Vidarabineapproved22024356-66-932326, 21704
Synonyms:
(+)-Cyclaradine
.beta.-Adenosine
.beta.-D-Adenosine
1odi
2-(6-AMINO-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
2946-52-3
2fqy
2gl0
30143-02-3
3080-29-3
3228-71-5
4005-33-8
46946-45-6
46969-16-8
524-69-6
5536-17-4
58-61-7
9-Arabinosyladenine
9-beta-D-Arabinofuranosyl-9H-purin-6-amine
9-beta-D-Arabinofuranosyl-adenine
9-beta-D-Arabinofuranosyladenine
9-beta-D-arabinofuranosyl-adenine
9-╬▓-D-arabinofuranosyl-9H-purin-6-amine
9-╬▓-D-arabinofuranosyladenine
A 9251
A0152
A4036_SIGMA
A4676_SIGMA
A5762_SIGMA
A9251_SIGMA
AC1L18OL
AC1L1U8O
AC1L2IWM
AC1L2SCM
AC1O4WIN
AC1O8PY7
AC1Q1ID3
AC1Q4Y1Z
AC1Q52XU
ADENOSINE, U.S.P.
ADN
AI3-52413
AI3-52821
AR-1H6029
ARA-A NSC 247519
Ade-Rib
Adenine Arabinoside
Adenine arabinoside
Adenine nucleoside
Adenine riboside
Adenine xyloside
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine arabinose
Adenosine-8-14C
Adensoine
Ambap5536-17-4
Ara A
Ara-A
Ara-ATP
Araadenosine
Arabinoside Adenine
Arabinoside adenine
Arabinosyl Adenine
Arabinosyl adenine
Arabinosyl-adenine
Arabinosyladenine
Arasena-A
Armes
Armes (TN)
BB_NC-0565
BPBio1_000898
BRN 0624881
BSPBio_000816
BSPBio_001796
BSPBio_002000
Bio1_000437
Bio1_000926
Bio1_001415
Boniton
C00212
CAS-5536-17-4
CCRIS 2557
CCRIS 3383
CHEBI:136932
CHEBI:16335
CHEBI:45327
CHEMBL1090
CHEMBL20247
CHEMBL477
CI 673
CI-673
CID102198
CID191
CID21704
CID60961
CID6420052
CID6713976
CPD000471872
Caswell No. 010B
D000241
D00045
D06298
DB00640
DivK1c_000191
EINECS 200-389-9
EINECS 217-911-6
EINECS 226-893-9
EU-0100123
FT-0082881
HMS1570I18
HMS1920A13
HMS1921K05
HMS2090F06
HMS2091G13
HMS2092C16
HMS500J13
HSDB 6514
 
I01-1121
IDI1_000191
KBio1_000191
KBio2_002418
KBio2_004986
KBio2_007554
KBio3_001296
KBio3_001500
KBioGR_001224
KBioSS_002424
L000094
LS-15059
LS-15085
Lopac0_000123
MEDR-640
MLS000069638
MLS000699527
MLS001066352
MLS001333133
MLS001333134
MLS002153227
MLS002153992
MolPort-001-785-903
MolPort-001-838-229
MolPort-003-666-308
Myocol
NCGC00016656-01
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NCGC00094579-01
NCGC00094579-02
NCGC00094579-03
NCGC00094579-04
NCGC00178869-01
NCGC00179417-01
NCI60_003823
NCI60_037192
NCIOpen2_003303
NCIOpen2_005376
NINDS_000191
NSC 247519
NSC 404241
NSC 627048
NSC 7359
NSC 7652
NSC-404241
NSC247519
NSC404241
NSC627048
NSC70422
NSC7359
NSC7652
NSC80832
NSC87676
NSC91041
Nucleocardyl
PDSP1_001036
PDSP2_001020
Pallacor
Polyadenosine
Polyriboadenosine
Prestwick0_000768
Prestwick1_000768
Prestwick2_000768
Prestwick3_000768
Prestwick_983
RAB
S1647_Selleck
S1784_Selleck
SAM002564191
SMP1_000312
SMR000058216
SMR000225041
SMR000471872
SMR001233326
SPBio_001194
SPBio_001491
SPBio_002755
SPECTRUM1500107
SPECTRUM1500609
SR 96225
SR-96225
STK361815
SUN-Y4001
Sandesin
Spectrum2_001257
Spectrum2_001336
Spectrum3_000288
Spectrum3_000580
Spectrum4_000782
Spectrum5_001429
Spectrum_001894
Spongoadenosine
TL8003749
UNII-3XQD2MEW34
UNII-K72T3FS567
USAF CB-10
V0098
VIRDARABINE
Vidarabin
Vidarabina
Vidarabina [DCIT]
Vidarabine
Vidarabine (JAN)
Vidarabine anhydrous
Vidarabinum
Vira ATM
Vira-A
Vira-A, Vidarabine
XA
Xylosyl A
Xylosyladenine
ZINC00970363
ZINC02169830
adenine-D-ribose
adenosine
alpha-Ara A
beta-Adenosine
beta-Ara A
beta-D-Adenosine
bmse000061
nchembio.143-comp9
nchembio.186-comp109
nchembio.64-comp4
nchembio706-5
9Vidarabine Phosphate110
10Fludarabine phosphate100830751
11Cyclosporins849

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study on Mastocytosis for Rupatadine TreatmentCompletedNCT01481909Phase 2, Phase 3
2A Phase 3 Study to Compare Efficacy and Safety of Masitinib to Placebo in the Treatment of Patients With Smouldering Systemic, Indolent Systemic or Cutaneous Mastocytosis With HandicapRecruitingNCT00814073Phase 3
3Efficacy of AB1010 in Patients With Systemic Indolent MastocytosisCompletedNCT00831974Phase 2
4Treatment of Indolent Systemic Mastocytosis With PA101RecruitingNCT02478957Phase 2
5Midostaurin in Indolent Systemic MastocytosisActive, not recruitingNCT01920204Phase 2
6Patient-Reported Outcome Questionnaire for Systemic MastocytosisRecruitingNCT02380222
7Mast Cell Connect: A Registry for Patients With MastocytosisRecruitingNCT02620254
8Diagnostic Value of Bone Marrow Tryptase in Systemic MastocytosisRecruitingNCT02441166
9Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic MalignanciesActive, not recruitingNCT00014235

Search NIH Clinical Center for Indolent Systemic Mastocytosis


Cochrane evidence based reviews: Mastocytosis, Systemic

Genetic Tests for Indolent Systemic Mastocytosis

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Anatomical Context for Indolent Systemic Mastocytosis

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MalaCards organs/tissues related to Indolent Systemic Mastocytosis:

33
Skin, Bone, Bone marrow, Colon

Animal Models for Indolent Systemic Mastocytosis or affiliated genes

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MGI Mouse Phenotypes related to Indolent Systemic Mastocytosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2KIT, KITLG, PDGFRA
2MP:00053977.2HDC, KIT, KITLG, MRAS, PDGFRA, TPMT

Publications for Indolent Systemic Mastocytosis

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Articles related to Indolent Systemic Mastocytosis:

(show all 40)
idTitleAuthorsYear
1
Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression. (26153655)
2015
2
The impact of sensitive KIT D816V detection on recognition of indolent Systemic Mastocytosis. (25582384)
2015
3
Response to celecoxib in a patient with indolent systemic mastocytosis presenting with intractable diarrhea. (26505934)
2015
4
Therapeutic challenge during the long-term follow-up of a patient with indolent systemic mastocytosis with extensive cutaneous involvement. (26004600)
2015
5
Sustained improvement in urticaria pigmentosa and pruritus in a case of indolent systemic mastocytosis treated with cladribine. (25515765)
2015
6
Endoscopic findings of indolent systemic mastocytosis involving the colon. (25526423)
2014
7
Serum levels of bone cytokines in indolent systemic mastocytosis associated with osteopenia or osteoporosis. (24439083)
2014
8
Delayed diagnosis of adult indolent systemic mastocytosis. (25386326)
2014
9
Predictors of new fragility fractures after diagnosis of indolent systemic mastocytosis. (24985401)
2014
10
MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis. (25542754)
2014
11
Indolent systemic mastocytosis in a patient with ileocolitis. (24975749)
2014
12
Omalizumab Induced Remission of Idiopathic Anaphylaxis in a Patient Suffering from Indolent Systemic Mastocytosis. (24162824)
2013
13
KIT D816V mutation burden does not correlate to clinical manifestations of indolent systemic mastocytosis. (23587333)
2013
14
Role of imatinib in the treatment of pediatric onset indolent systemic mastocytosis: a case report. (23659595)
2013
15
Serum tryptase monitoring in indolent systemic mastocytosis: association with disease features and patient outcome. (24155887)
2013
16
Prevalence of indolent systemic mastocytosis in a Dutch region. (23219169)
2013
17
Indolent systemic mastocytosis limited to the bone: a case report and review of the literature. (23903270)
2013
18
Serum tryptase correlates with the KIT D816V mutation burden in adults with indolent systemic mastocytosis. (23621866)
2013
19
Indolent systemic mastocytosis: a case and review of the current available treatment options. (24011312)
2013
20
Serum levels of bone cytokines are increased in indolent systemic mastocytosis associated with osteopenia or osteoporosis. (23910691)
2013
21
Circulating KIT D816V mutation-positive non-mast cells in peripheral blood are characteristic of indolent systemic mastocytosis. (22469616)
2012
22
Indolent systemic mastocytosis: is there a reliable radiographic pattern? (22281758)
2012
23
Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions. (22435702)
2012
24
High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis. (22229787)
2012
25
Indolent systemic mastocytosis treated with narrow-band UVB phototherapy: study of five cases. (21564325)
2012
26
Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis. (21193416)
2011
27
Bone mineral density, bone turnover markers and fractures in patients with indolent systemic mastocytosis. (21782049)
2011
28
Indolent systemic mastocytosis without skin involvement vs. isolated bone marrow mastocytosis. (21454873)
2011
29
Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis. (21143240)
2011
30
Gene expression profile, pathways, and transcriptional system regulation in indolent systemic mastocytosis. (21208217)
2011
31
Indolent systemic mastocytosis. (20684189)
2010
32
Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. (19541349)
2009
33
Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease. (18448146)
2008
34
High omalizumab dose controls recurrent reactions to venom immunotherapy in indolent systemic mastocytosis. (18269681)
2008
35
Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis. (18177694)
2008
36
Use of a doula for labor coaching in a patient with indolent systemic mastocytosis in pregnancy. (16449169)
2006
37
Indolent systemic mastocytosis as the cause of a long history of unexplained hypotensive episodes. (16929885)
2006
38
Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes. (15722637)
2005
39
Evolution of urticaria pigmentosa into indolent systemic mastocytosis: abnormal immunophenotype of mast cells without evidence of c-kit mutation ASP-816-VAL. (12688351)
2003
40
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. (9440541)
1997

Variations for Indolent Systemic Mastocytosis

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Expression for genes affiliated with Indolent Systemic Mastocytosis

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Search GEO for disease gene expression data for Indolent Systemic Mastocytosis.

Pathways for genes affiliated with Indolent Systemic Mastocytosis

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Pathways related to Indolent Systemic Mastocytosis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KIT, KITLG
29.7KIT, KITLG
39.5KIT, PDGFRA
49.5KIT, PDGFRA
59.3MRAS, PDGFRA
69.1KIT, KITLG, PDGFRA
79.1KIT, KITLG, PDGFRA
89.1KIT, KITLG, PDGFRA
9
Show member pathways
8.5KIT, KITLG, MRAS, PDGFRA
10
Show member pathways
8.5KIT, KITLG, MRAS, PDGFRA
11
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
12
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
13
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
14
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
15
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
16
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
17
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
18
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA
19
Show member pathways
8.1CLEC11A, KIT, KITLG, MRAS, PDGFRA

GO Terms for genes affiliated with Indolent Systemic Mastocytosis

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Biological processes related to Indolent Systemic Mastocytosis according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:003516210.3KIT, KITLG
2ectopic germ cell programmed cell deathGO:003523410.3KIT, KITLG
3positive regulation of MAP kinase activityGO:004340610.1KIT, KITLG
4positive regulation of phospholipase C activityGO:001086310.1KIT, PDGFRA
5ovarian follicle developmentGO:000154110.1KIT, KITLG
6positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.0KIT, PDGFRA
7positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.0KIT, PDGFRA
8positive regulation of DNA replicationGO:00457409.9KITLG, PDGFRA
9cell chemotaxisGO:00603269.6KIT, PDGFRA
10phosphatidylinositol-mediated signalingGO:00480159.6KIT, KITLG, PDGFRA
11MAPK cascadeGO:00001659.4KIT, KITLG, PDGFRA
12activation of MAPKK activityGO:00001869.4KIT, KITLG, PDGFRA
13insulin receptor signaling pathwayGO:00082869.3KIT, KITLG, PDGFRA
14fibroblast growth factor receptor signaling pathwayGO:00085439.3KIT, KITLG, PDGFRA
15Fc-epsilon receptor signaling pathwayGO:00380959.3KIT, KITLG, PDGFRA
16neurotrophin TRK receptor signaling pathwayGO:00480119.2KIT, KITLG, PDGFRA
17epidermal growth factor receptor signaling pathwayGO:00071739.1KIT, KITLG, PDGFRA
18positive regulation of cell proliferationGO:00082849.0CLEC11A, KIT, KITLG, PDGFRA
19Ras protein signal transductionGO:00072658.8KIT, KITLG, MRAS, PDGFRA
20vascular endothelial growth factor receptor signaling pathwayGO:00480108.8KIT, KITLG, PDGFRA
21small GTPase mediated signal transductionGO:00072648.5KIT, KITLG, MRAS, PDGFRA

Molecular functions related to Indolent Systemic Mastocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.5KIT, PDGFRA

Sources for Indolent Systemic Mastocytosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet