IDF
MCID: INF046
MIFTS: 30

Infantile Digital Fibromatosis (IDF) malady

Skin diseases, Cancer diseases categories

Summaries for Infantile Digital Fibromatosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Infantile digital fibromatosis (also known as an \"Inclusion body fibromatosis,\" \"Infantile digital... more...

MalaCards: Infantile Digital Fibromatosis, also known as asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes, is related to benign breast phyllodes tumor and syndactyly. An important gene associated with Infantile Digital Fibromatosis is DES (desmin), and among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Classifications for Infantile Digital Fibromatosis

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
infantile digital fibromatosis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

infantile digital fibromatosis 42 48 60
asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes 42
recurring digital fibrous tumor of childhood 48
inclusion body fibromatosis 48
reye tumor 48
idf 42


External Ids:

ICD10 via Orphanet26 M72.8
SNOMED-CT via Orphanet57 399903008
UMLS via Orphanet61 C1318562

Related Diseases for Infantile Digital Fibromatosis

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17GeneCards, 18GeneDecks
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Diseases related to Infantile Digital Fibromatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1benign breast phyllodes tumor10.2
2syndactyly10.2
3herpes simplex10.2
4intermittent claudication10.0
5diabetes mellitus10.0
6type 2 diabetes mellitus10.0
7adenomatoid tumor10.0VIM
8myoepithelioma10.0VIM
9perineurioma10.0VIM
10angiosarcoma10.0VIM
11infantile myofibromatosis10.0DES
12epidermolysis bullosa simplex10.0DES
13lymphangioleiomyomatosis10.0DES
14lipoma10.0DES
15medulloblastoma10.0DES
16epithelioid leiomyosarcoma10.0DES, VIM
17mesenchymal chondrosarcoma10.0VIM, DES
18pseudosarcomatous fibromatosis10.0VIM, DES
19spindle cell carcinoma10.0DES, VIM
20spindle cell sarcoma10.0VIM, DES
21alveolar soft part sarcoma10.0DES, VIM
22fibrous histiocytoma10.0VIM, DES
23endometrial stromal sarcoma10.0DES, VIM
24sex cord-gonadal stromal tumor10.0DES, VIM
25malignant mixed mullerian tumor10.0VIM, DES
26glomus tumor10.0VIM, DES
27giant cell tumor10.0VIM, DES
28abrikosov's tumor10.0VIM, DES
29sertoli cell tumor10.0VIM, DES
30pleomorphic adenoma10.0VIM, DES
31malignant fibroxanthoma10.0VIM, DES
32dermatofibrosarcoma protuberans10.0VIM, DES
33synovial sarcoma10.0VIM, DES
34granular cell tumor10.0DES, VIM
35hemangiopericytoma10.0VIM, DES
36smooth muscle tumor10.0DES, VIM
37neurilemmoma10.0DES, VIM
38angiomyolipoma10.0VIM, DES
39benign mesothelioma10.0DES, VIM
40fibromatosis10.0VIM, DES
41rhabdoid tumor10.0VIM, DES
42peripheral primitive neuroectodermal tumor10.0DES, VIM
43chordoma10.0DES, VIM
44leiomyosarcoma10.0VIM, DES
45liposarcoma10.0VIM, DES
46gastrointestinal stromal tumor10.0VIM, DES
47malignant mesothelioma10.0VIM, DES
48chondrosarcoma10.0VIM, DES
49fibrosarcoma10.0DES, VIM
50wilms tumor10.0DES, VIM

Graphical network of the top 20 diseases related to Infantile Digital Fibromatosis:



Diseases related to infantile digital fibromatosis

Clinical Features for Infantile Digital Fibromatosis

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Drugs & Therapeutics for Infantile Digital Fibromatosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Infantile Digital Fibromatosis

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Anatomical Context for Infantile Digital Fibromatosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Infantile Digital Fibromatosis:

32
Skin

Animal Models for Infantile Digital Fibromatosis or affiliated genes

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Publications for Infantile Digital Fibromatosis

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Genetic Variations for Infantile Digital Fibromatosis

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Expression for genes affiliated with Infantile Digital Fibromatosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infantile Digital Fibromatosis

Search GEO for disease gene expression data for Infantile Digital Fibromatosis.

Pathways for genes affiliated with Infantile Digital Fibromatosis

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Sources:
4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1DES, VIM
2
Hide members
9.1DES, VIM
3
Hide members
9.1DES, VIM
49.1DES, VIM

Compounds for genes affiliated with Infantile Digital Fibromatosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1orcein449.5DES, VIM
2s 100449.5DES, VIM
3toluidine449.5DES, VIM
4reticulin449.5DES, VIM
5mucicarmine449.5VIM, DES
6phalloidin449.5DES, VIM
7b 723449.5DES, VIM
8gemfibrozil44 28 1111.5DES, VIM
9bezafibrate44 28 1111.5VIM, DES
10acetaldehyde44 28 2411.5DES, VIM
11fenofibrate44 49 1111.5DES, VIM
12hematoxylin449.5DES, VIM
13ganglioside449.5VIM, DES
14procollagen449.5DES, VIM
15progestin449.5DES, VIM
16azathioprine44 49 2 1112.5DES, VIM
17biotin44 11 2411.4VIM, DES
18adriamycin449.4DES, VIM
19bromodeoxyuridine449.4DES, VIM
20dihydrotestosterone44 28 11 2412.4DES, VIM
21hyaluronic acid44 2410.4VIM, DES
22formaldehyde44 2410.4DES, VIM
23heparan sulfate44 2410.4DES, VIM
2412-o-tetradecanoylphorbol 13-acetate449.4DES, VIM
25methionine449.3VIM, DES
26doxorubicin44 49 1111.3DES, VIM
27glycogen44 2410.3DES, VIM
28actinomycin d449.2DES, VIM
29estradiol44 11 2411.2VIM, DES
30paraffin449.1DES, VIM
31lysine449.1DES, VIM
32proline449.0DES, VIM
33iron44 249.8DES, VIM

GO Terms for genes affiliated with Infantile Digital Fibromatosis

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Sources:
16Gene Ontology
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Cellular components related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1DES, VIM

Biological processes related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.1DES, VIM

Molecular functions related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.1DES, VIM

Products for genes affiliated with Infantile Digital Fibromatosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Infantile Digital Fibromatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet