MCID: INF046
MIFTS: 32

Infantile Digital Fibromatosis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Infantile Digital Fibromatosis

MalaCards integrated aliases for Infantile Digital Fibromatosis:

Name: Infantile Digital Fibromatosis 49 55 69
Asymptomatic Nodular Proliferation of Fibrous Tissue on the Dorsal and Lateral Aspects of the Fingers or Toes 49
Recurring Digital Fibrous Tumor of Childhood 55
Inclusion Body Fibromatosis 55
Reye Tumor 55
Idf 49

Characteristics:

Orphanet epidemiological data:

55
infantile digital fibromatosis
Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA199267
UMLS via Orphanet 70 C1318562
ICD10 via Orphanet 33 M72.8
SNOMED-CT via HPO 65 95319004
UMLS 69 C1318562

Summaries for Infantile Digital Fibromatosis

MalaCards based summary : Infantile Digital Fibromatosis, also known as asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes, is related to fibromatosis and benign breast phyllodes tumor, and has symptoms including skin nodule An important gene associated with Infantile Digital Fibromatosis is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeleton remodeling Neurofilaments and Cytoskeletal Signaling. Affiliated tissues include skin and breast.

Wikipedia : 72 Infantile digital fibromatosis (also known as an \"Inclusion body fibromatosis,\" \"Infantile digital... more...

Related Diseases for Infantile Digital Fibromatosis

Diseases related to Infantile Digital Fibromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 fibromatosis 30.8 DES VIM
2 benign breast phyllodes tumor 10.0
3 aging 9.9
4 diabetes mellitus 9.9
5 intermittent claudication 9.9
6 chromosome 2q35 duplication syndrome 9.9
7 terminal osseous dysplasia 9.9
8 herpes simplex 9.9
9 skin glomus tumor 9.9 DES VIM
10 lymphangiomatosis 9.9 DES VIM
11 angiolipoma 9.9 DES VIM
12 primitive neuroectodermal tumor of the cervix uteri 9.8 DES VIM
13 cutaneous leiomyosarcoma 9.8 DES VIM
14 spindle cell lipoma 9.8 DES VIM
15 parachordoma 9.8 DES VIM
16 epulis 9.8 DES VIM
17 ossifying fibromyxoid tumor 9.8 DES VIM
18 epithelioid leiomyosarcoma 9.8 DES VIM
19 biphasic synovial sarcoma 9.8 DES VIM
20 syringocystadenoma papilliferum 9.8 DES VIM
21 benign metastasizing leiomyoma 9.8 DES VIM
22 congenital fibrosarcoma 9.8 DES VIM
23 syringoma 9.8 DES VIM
24 juvenile xanthogranuloma 9.8 DES VIM
25 pleomorphic liposarcoma 9.8 DES VIM
26 perivascular epithelioid cell tumor 9.8 DES VIM
27 cutaneous fibrous histiocytoma 9.8 DES VIM
28 reticulum cell sarcoma 9.8 DES VIM
29 spindle cell sarcoma 9.8 DES VIM
30 mesenchymal chondrosarcoma 9.8 DES VIM
31 extraskeletal ewing sarcoma 9.8 DES VIM
32 pseudosarcomatous fibromatosis 9.8 DES VIM
33 glomus tumor 9.8 DES VIM
34 granular cell tumor 9.8 DES VIM
35 congenital epulis 9.8 DES VIM
36 embryonal sarcoma 9.8 DES VIM
37 infantile myofibromatosis 9.8 DES VIM
38 smooth muscle tumor 9.8 DES VIM
39 hemangiopericytoma, malignant 9.8 DES VIM
40 benign mesothelioma 9.8 DES VIM
41 malignant fibroxanthoma 9.8 DES VIM
42 chondromyxoid fibroma 9.8 DES VIM
43 fasciitis 9.8 DES VIM
44 glomangioma 9.7 DES VIM
45 spindle cell carcinoma 9.7 DES VIM
46 chordoma 9.7 DES VIM
47 rhabdoid cancer 9.7 DES VIM
48 desmoplastic small round cell tumor 9.7 DES VIM
49 neurilemmoma 9.7 DES VIM
50 fibrous histiocytoma 9.7 DES VIM

Graphical network of the top 20 diseases related to Infantile Digital Fibromatosis:



Diseases related to Infantile Digital Fibromatosis

Symptoms & Phenotypes for Infantile Digital Fibromatosis

Human phenotypes related to Infantile Digital Fibromatosis:

55 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 skin nodule 55 31 obligate (100%) Obligate (100%) HP:0200036

Drugs & Therapeutics for Infantile Digital Fibromatosis

Search Clinical Trials , NIH Clinical Center for Infantile Digital Fibromatosis

Genetic Tests for Infantile Digital Fibromatosis

Anatomical Context for Infantile Digital Fibromatosis

MalaCards organs/tissues related to Infantile Digital Fibromatosis:

38
Skin, Breast

Publications for Infantile Digital Fibromatosis

Articles related to Infantile Digital Fibromatosis:

(show top 50) (show all 54)
# Title Authors Year
1
Infantile digital fibromatosis-like tumor of adult. ( 29319280 )
2018
2
Case of infantile digital fibromatosis: Observation of its dermoscopic features. ( 27859517 )
2016
3
Benign Nerve Sheath Myxoma in an Infant Misdiagnosed as Infantile Digital Fibromatosis. ( 27196676 )
2016
4
Infantile Digital Fibromatosis: A Rare Case Report. ( 27057032 )
2016
5
A case of infantile digital fibromatosis: differential diagnosis and treatment. ( 23330824 )
2014
6
Infantile digital fibromatosis: a rare myofibrocytic tumor with characteristic histopathology. ( 25482706 )
2014
7
Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis. ( 24117680 )
2013
8
Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement. ( 23716832 )
2013
9
Case report of an ulcerated infantile digital fibromatosis in an older child. The lump to spot in the child's hand (a spot not to lump in with the others). ( 23578982 )
2013
10
Diagnosis and treatment of digitocutaneous dysplasia, a rare infantile digital fibromatosis: a case report. ( 24426970 )
2013
11
Infantile digital fibromatosis. ( 23241193 )
2013
12
Infantile digital fibromatosis: a rare tumour of infancy. Report of five cases. ( 23157779 )
2012
13
Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. ( 20937573 )
2011
14
Infantile digital fibromatosis: our experience and long-term results. ( 21276743 )
2011
15
Key cytological findings in FNA from infantile digital fibromatosis. ( 21986179 )
2011
16
Congenital infantile digital fibromatosis: a case report and review of the literature. ( 21139926 )
2009
17
Infantile digital fibromatosis. ( 18571599 )
2008
18
A range of histologic findings in infantile digital fibromatosis. ( 18304159 )
2008
19
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. ( 18266786 )
2008
20
Infantile digital fibromatosis. ( 18812724 )
2008
21
Infantile digital fibromatosis. ( 17273037 )
2007
22
Further documentation of spontaneous regression of infantile digital fibromatosis. ( 17542881 )
2007
23
An unusual congenital presentation of infantile digital fibromatosis. ( 17535189 )
2007
24
Intralesional fluorouracil injection in infantile digital fibromatosis. ( 15897374 )
2005
25
Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome. ( 15864382 )
2005
26
Congenital infantile digital fibromatosis. ( 12220294 )
2002
27
Infantile digital fibromatosis - a case report. ( 11164672 )
2001
28
Recurrent infantile digital fibromatosis--a rare entity. ( 11883128 )
2001
29
Infantile digital fibromatosis: an unusual localization. ( 11584416 )
2001
30
A case of infantile digital fibromatosis with spontaneous regression. ( 9769598 )
1998
31
Recurring infantile digital fibromatosis: report of two cases. ( 7722838 )
1995
32
Infantile digital fibromatosis: a study of the development and regression of cytoplasmic inclusion bodies. ( 7675776 )
1995
33
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. ( 8172324 )
1994
34
Immunohistochemical identification of aggregated actin filaments in formalin-fixed, paraffin-embedded sections. I. A study of infantile digital fibromatosis by a new pretreatment. ( 1310240 )
1992
35
Infantile digital fibromatosis: ultrastructural human papillomavirus and herpes simplex virus DNA observation. ( 1656415 )
1991
36
SH abundant body in infantile digital fibromatosis--a histochemical study on distribution of sulfhydryl groups. ( 2177484 )
1990
37
Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. ( 1697612 )
1990
38
A case of infantile digital fibromatosis showing spontaneous regression. ( 2667619 )
1989
39
Infantile digital fibromatosis-like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings. ( 2836293 )
1988
40
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions. ( 2827878 )
1988
41
Posttraumatic occurrence of infantile digital fibromatosis. A histologic and electron microscopic study. ( 3740876 )
1986
42
Infantile digital fibromatosis after web construction in syndactyly. ( 3020117 )
1986
43
Identification of actin microfilaments in the intracytoplasmic inclusions present in recurring infantile digital fibromatosis (Reye tumor). ( 3029741 )
1986
44
Infantile digital fibromatosis. An electron microscopic and immunohistochemical study. ( 3811906 )
1986
45
Infantile digital fibromatosis occurring outside the digit. ( 6496846 )
1984
46
Infantile digital fibromatosis. ( 6545884 )
1984
47
Infantile digital fibromatosis--a case report: an electron microscope study. ( 6582225 )
1983
48
Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding. ( 6311399 )
1983
49
Ultrastructural histochemistry of infantile digital fibromatosis. ( 6270858 )
1981
50
Cell culture of infantile digital fibromatosis. ( 6249721 )
1980

Variations for Infantile Digital Fibromatosis

Expression for Infantile Digital Fibromatosis

Search GEO for disease gene expression data for Infantile Digital Fibromatosis.

Pathways for Infantile Digital Fibromatosis

Pathways related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 DES VIM
2 11.29 CNN1 DES VIM
3 11.24 CNN1 DES
4 11.01 DES VIM
5
Show member pathways
10.61 DES VIM

GO Terms for Infantile Digital Fibromatosis

Cellular components related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.96 DES VIM
2 cytoskeleton GO:0005856 8.8 CNN1 DES VIM

Biological processes related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.96 DES VIM
2 intermediate filament organization GO:0045109 8.62 DES VIM

Molecular functions related to Infantile Digital Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 DES VIM

Sources for Infantile Digital Fibromatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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