IDF
MCID: INF046
MIFTS: 38

Infantile Digital Fibromatosis (IDF) malady

Rare diseases, Skin diseases, Cancer diseases categories

Summaries for Infantile Digital Fibromatosis

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Wikipedia:64 Infantile digital fibromatosis (also known as an \"Inclusion body fibromatosis,\" \"Infantile digital... more...

MalaCards based summary: Infantile Digital Fibromatosis, also known as asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes, is related to fibromatosis and fibroma. An important gene associated with Infantile Digital Fibromatosis is DES (desmin), and among its related pathways are Cytoskeletal Signaling and Cytoplasmic microtubules. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Aliases & Classifications for Infantile Digital Fibromatosis

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Sources:
42NIH Rare Diseases, 48Orphanet, 61UMLS, 62UMLS via Orphanet, 27ICD10 via Orphanet
See all sources

Infantile Digital Fibromatosis, Aliases & Descriptions:

Name: Infantile Digital Fibromatosis 42 48 61
Asymptomatic Nodular Proliferation of Fibrous Tissue on the Dorsal and Lateral Aspects of the Fingers or Toes 42
Recurring Digital Fibrous Tumor of Childhood 48
 
Inclusion Body Fibromatosis 48
Reye Tumor 48
Idf 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
infantile digital fibromatosis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


External Ids:

UMLS via Orphanet62 C1318562
ICD10 via Orphanet27 M72.8

Related Diseases for Infantile Digital Fibromatosis

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Diseases related to Infantile Digital Fibromatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1fibromatosis31.7VIM, DES
2fibroma30.4DES, VIM
3phyllode tumor10.4
4adenomatoid tumor10.4VIM
5infantile myofibromatosis10.3DES
6syndactyly10.3
7herpes simplex10.3
8terminal osseous dysplasia10.3
9epithelioid leiomyosarcoma10.1VIM, DES
10mesenchymal chondrosarcoma10.1VIM, DES
11diabetes mellitus10.1
12intermittent claudication10.1
13type 2 diabetes mellitus10.1
14pseudosarcomatous fibromatosis10.1DES, VIM
15spindle cell carcinoma10.1DES, VIM
16alveolar soft part sarcoma10.1VIM, DES
17spindle cell sarcoma10.1VIM, DES
18sertoli cell tumor10.1VIM, DES
19granular cell tumor10.1DES, VIM
20dermatofibrosarcoma protuberans10.1DES, VIM
21fibrous histiocytoma10.1DES, VIM
22endometrial stromal sarcoma10.1VIM, DES
23rhabdoid tumor10.0DES, VIM
24sex cord-gonadal stromal tumor10.0VIM, DES
25hemangiopericytoma10.0VIM, DES
26angiomyolipoma10.0VIM, DES
27paraganglioma10.0DES, VIM
28malignant mixed mullerian tumor10.0DES, VIM
29chordoma10.0DES, VIM
30smooth muscle tumor10.0VIM, DES
31abrikosov's tumor10.0DES, VIM
32giant cell tumor10.0DES, VIM
33pleomorphic adenoma10.0VIM, DES
34malignant fibroxanthoma10.0VIM, DES
35liposarcoma10.0DES, VIM
36synovial sarcoma10.0VIM, DES
37gastrointestinal stromal tumor10.0DES, VIM
38leiomyosarcoma10.0VIM, DES
39neurilemmoma10.0VIM, DES
40malignant mesothelioma10.0VIM, DES
41leiomyoma9.9VIM, DES
42peripheral primitive neuroectodermal tumor9.9VIM, DES
43chondrosarcoma9.9VIM, DES
44rhabdomyosarcoma9.9DES, VIM
45sarcoma9.9VIM, DES
46wilms tumor9.8VIM, DES
47fibrosarcoma9.8DES, VIM

Graphical network of the top 20 diseases related to Infantile Digital Fibromatosis:



Diseases related to infantile digital fibromatosis

Symptoms for Infantile Digital Fibromatosis

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Drugs & Therapeutics for Infantile Digital Fibromatosis

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Drug clinical trials:

Search ClinicalTrials for Infantile Digital Fibromatosis

Search NIH Clinical Center for Infantile Digital Fibromatosis

Genetic Tests for Infantile Digital Fibromatosis

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Anatomical Context for Infantile Digital Fibromatosis

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MalaCards organs/tissues related to Infantile Digital Fibromatosis:

32
Skin, Breast

Animal Models for Infantile Digital Fibromatosis or affiliated genes

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Publications for Infantile Digital Fibromatosis

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Articles related to Infantile Digital Fibromatosis:

(show all 49)
idTitleAuthorsYear
1
A case of infantile digital fibromatosis: differential diagnosis and treatment. (23330824)
2014
2
Infantile digital fibromatosis. (23241193)
2013
3
Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis. (24117680)
2013
4
Diagnosis and treatment of digitocutaneous dysplasia, a rare infantile digital fibromatosis: a case report. (24426970)
2013
5
Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement. (23716832)
2013
6
Case report of an ulcerated infantile digital fibromatosis in an older child. The lump to spot in the child's hand (a spot not to lump in with the others). (23578982)
2013
7
Infantile digital fibromatosis: a rare tumour of infancy. Report of five cases. (23157779)
2012
8
Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. (20937573)
2011
9
Key cytological findings in FNA from infantile digital fibromatosis. (21986179)
2011
10
Infantile digital fibromatosis: our experience and long-term results. (21276743)
2011
11
Congenital infantile digital fibromatosis: a case report and review of the literature. (21139926)
2009
12
Infantile digital fibromatosis. (18812724)
2008
13
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. (18266786)
2008
14
Infantile digital fibromatosis. (18571599)
2008
15
A range of histologic findings in infantile digital fibromatosis. (18304159)
2008
16
Further documentation of spontaneous regression of infantile digital fibromatosis. (17542881)
2007
17
Infantile digital fibromatosis. (17273037)
2007
18
An unusual congenital presentation of infantile digital fibromatosis. (17535189)
2007
19
Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome. (15864382)
2005
20
Intralesional fluorouracil injection in infantile digital fibromatosis. (15897374)
2005
21
Congenital infantile digital fibromatosis. (12220294)
2002
22
Recurrent infantile digital fibromatosis--a rare entity. (11883128)
2001
23
Infantile digital fibromatosis - a case report. (11164672)
2001
24
Infantile digital fibromatosis: an unusual localization. (11584416)
2001
25
A case of infantile digital fibromatosis with spontaneous regression. (9769598)
1998
26
Infantile digital fibromatosis: a study of the development and regression of cytoplasmic inclusion bodies. (7675776)
1995
27
Recurring infantile digital fibromatosis: report of two cases. (7722838)
1995
28
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. (8172324)
1994
29
Immunohistochemical identification of aggregated actin filaments in formalin-fixed, paraffin-embedded sections. I. A study of infantile digital fibromatosis by a new pretreatment. (1310240)
1992
30
Infantile digital fibromatosis: ultrastructural human papillomavirus and herpes simplex virus DNA observation. (1656415)
1991
31
SH abundant body in infantile digital fibromatosis--a histochemical study on distribution of sulfhydryl groups. (2177484)
1990
32
Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. (1697612)
1990
33
A case of infantile digital fibromatosis showing spontaneous regression. (2667619)
1989
34
Infantile digital fibromatosis-like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings. (2836293)
1988
35
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions. (2827878)
1988
36
Posttraumatic occurrence of infantile digital fibromatosis. A histologic and electron microscopic study. (3740876)
1986
37
Infantile digital fibromatosis. An electron microscopic and immunohistochemical study. (3811906)
1986
38
Infantile digital fibromatosis after web construction in syndactyly. (3020117)
1986
39
Identification of actin microfilaments in the intracytoplasmic inclusions present in recurring infantile digital fibromatosis (Reye tumor). (3029741)
1986
40
Infantile digital fibromatosis occurring outside the digit. (6496846)
1984
41
Infantile digital fibromatosis. (6545884)
1984
42
Infantile digital fibromatosis--a case report: an electron microscope study. (6582225)
1983
43
Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding. (6311399)
1983
44
Ultrastructural histochemistry of infantile digital fibromatosis. (6270858)
1981
45
Infantile digital fibromatosis. Ultrastructural, histochemical, and tissue culture observations. (6253042)
1980
46
Cell culture of infantile digital fibromatosis. (6249721)
1980
47
Infantile digital fibromatosis. (4431801)
1974
48
Infantile digital fibromatosis. Histopathological and electron microscopic study with a review of the literature. (4376326)
1974
49
Infantile digital fibromatosis and aponeurotic fibroma. Case reports of tow rare pseudosarcomas and review of the literature. (5761804)
1969

Variations for Infantile Digital Fibromatosis

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Expression for genes affiliated with Infantile Digital Fibromatosis

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Expression patterns in normal tissues for genes affiliated with Infantile Digital Fibromatosis

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Pathways for genes affiliated with Infantile Digital Fibromatosis

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Pathways related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1VIM, DES
2
Show member pathways
Cytoskeleton remodeling Neurofilaments59
9.1VIM, DES
3
Show member pathways
9.1VIM, DES
4
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.1VIM, DES

Compounds for genes affiliated with Infantile Digital Fibromatosis

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Compounds related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1orcein449.6VIM, DES
2s 100449.6VIM, DES
3toluidine449.6DES, VIM
4reticulin449.6VIM, DES
5mucicarmine449.6VIM, DES
6phalloidin449.6DES, VIM
7b 723449.5VIM, DES
8gemfibrozil29 44 1211.5VIM, DES
9bezafibrate44 29 1211.5DES, VIM
10acetaldehyde29 44 2511.5VIM, DES
11dermatan sulfate449.5DES, VIM
12fenofibrate44 50 1211.5VIM, DES
13hematoxylin449.5VIM, DES
14ganglioside449.5DES, VIM
15procollagen449.5VIM, DES
16progestin449.5VIM, DES
17azathioprine44 3 50 1212.5DES, VIM
18biotin44 25 1211.5VIM, DES
19adriamycin449.5VIM, DES
20bromodeoxyuridine449.5DES, VIM
21dihydrotestosterone44 29 25 1212.5VIM, DES
22hyaluronic acid44 2510.5DES, VIM
23formaldehyde44 2510.5VIM, DES
24heparan sulfate44 2510.5VIM, DES
2512-o-tetradecanoylphorbol 13-acetate449.5DES, VIM
26methionine449.5VIM, DES
27acetylcholine44 50 29 25 1213.4VIM, DES
28doxorubicin44 50 1211.4DES, VIM
29glycogen44 2510.4VIM, DES
30actinomycin d449.4VIM, DES
31estradiol44 25 1211.4DES, VIM
32paraffin449.4VIM, DES
33proline449.4DES, VIM
34iron44 2510.4VIM, DES
35lysine449.3VIM, DES
36lactate449.3DES, VIM
37creatinine449.3VIM, DES
38heparin44 29 25 1212.2DES, VIM
39adenylate449.2VIM, DES
40cyclic amp44 2510.1VIM, DES
41testosterone44 60 25 1212.1VIM, DES
42progesterone44 29 60 25 1213.0DES, VIM
43h2o2448.8VIM, DES

GO Terms for genes affiliated with Infantile Digital Fibromatosis

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Cellular components related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1VIM, DES

Biological processes related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.1VIM, DES

Molecular functions related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1VIM, DES
2structural constituent of cytoskeletonGO:0052008.8VIM, DES

Products for genes affiliated with Infantile Digital Fibromatosis

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Sources for Infantile Digital Fibromatosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet