IDF
MCID: INF046
MIFTS: 38

Infantile Digital Fibromatosis (IDF) malady

Rare diseases, Skin diseases, Cancer diseases categories
Download this MalaCard

Summaries for Infantile Digital Fibromatosis

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Infantile digital fibromatosis (also known as an \"Inclusion body fibromatosis,\" \"Infantile digital... more...

MalaCards: Infantile Digital Fibromatosis, also known as asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes, is related to fibromatosis and fibroma. An important gene associated with Infantile Digital Fibromatosis is DES (desmin), and among its related pathways are Cytoskeletal Signaling and Cytoplasmic microtubules. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Aliases & Classifications for Infantile Digital Fibromatosis

About this section
Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

49
infantile digital fibromatosis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

infantile digital fibromatosis 43 49 62
asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes 43
recurring digital fibrous tumor of childhood 49
inclusion body fibromatosis 49
reye tumor 49
idf 43


External Ids:

ICD10 via Orphanet26 M72.8
SNOMED-CT via Orphanet59 399903008
UMLS via Orphanet63 C1318562

Related Diseases for Infantile Digital Fibromatosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Infantile Digital Fibromatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1fibromatosis31.6VIM, DES
2fibroma30.4DES, VIM
3phyllode tumor10.4
4syndactyly10.2
5herpes simplex10.2
6terminal osseous dysplasia10.2
7adenomatoid tumor10.1VIM
8infantile myofibromatosis10.1DES
9intermittent claudication10.0
10diabetes mellitus10.0
11type 2 diabetes mellitus10.0
12epithelioid leiomyosarcoma10.0VIM, DES
13mesenchymal chondrosarcoma10.0VIM, DES
14pseudosarcomatous fibromatosis10.0DES, VIM
15spindle cell carcinoma10.0DES, VIM
16alveolar soft part sarcoma10.0VIM, DES
17spindle cell sarcoma10.0VIM, DES
18sertoli cell tumor10.0VIM, DES
19granular cell tumor10.0DES, VIM
20dermatofibrosarcoma protuberans10.0DES, VIM
21fibrous histiocytoma10.0DES, VIM
22endometrial stromal sarcoma10.0VIM, DES
23rhabdoid tumor10.0DES, VIM
24sex cord-gonadal stromal tumor10.0VIM, DES
25hemangiopericytoma10.0VIM, DES
26angiomyolipoma10.0VIM, DES
27glomus tumor10.0DES, VIM
28malignant mixed mullerian tumor10.0DES, VIM
29chordoma10.0DES, VIM
30smooth muscle tumor10.0VIM, DES
31abrikosov's tumor10.0DES, VIM
32giant cell tumor10.0DES, VIM
33pleomorphic adenoma10.0VIM, DES
34malignant fibroxanthoma10.0VIM, DES
35liposarcoma10.0DES, VIM
36synovial sarcoma10.0VIM, DES
37gastrointestinal stromal tumor10.0DES, VIM
38leiomyosarcoma10.0VIM, DES
39neurilemmoma10.0VIM, DES
40malignant mesothelioma10.0DES, VIM
41benign mesothelioma10.0VIM, DES
42leiomyoma10.0VIM, DES
43peripheral primitive neuroectodermal tumor10.0VIM, DES
44chondrosarcoma10.0VIM, DES
45rhabdomyosarcoma10.0DES, VIM
46sarcoma10.0VIM, DES
47wilms tumor10.0VIM, DES
48fibrosarcoma9.9DES, VIM

Graphical network of the top 20 diseases related to Infantile Digital Fibromatosis:



Diseases related to infantile digital fibromatosis

Symptoms for Infantile Digital Fibromatosis

About this section

Drugs & Therapeutics for Infantile Digital Fibromatosis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Infantile Digital Fibromatosis

Search NIH Clinical Center for Infantile Digital Fibromatosis

Genetic Tests for Infantile Digital Fibromatosis

About this section

Anatomical Context for Infantile Digital Fibromatosis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Infantile Digital Fibromatosis:

33
Skin, Breast

Animal Models for Infantile Digital Fibromatosis or affiliated genes

About this section

Publications for Infantile Digital Fibromatosis

About this section
Sources:
52PubMed
See all sources

Articles related to Infantile Digital Fibromatosis:

(show all 48)
idTitleAuthorsYear
1
A case of infantile digital fibromatosis: differential diagnosis and treatment. (23330824)
2014
2
Infantile digital fibromatosis. (23241193)
2013
3
Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis. (24117680)
2013
4
Diagnosis and treatment of digitocutaneous dysplasia, a rare infantile digital fibromatosis: a case report. (24426970)
2013
5
Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement. (23716832)
2013
6
Case report of an ulcerated infantile digital fibromatosis in an older child. The lump to spot in the child's hand (a spot not to lump in with the others). (23578982)
2013
7
Infantile digital fibromatosis: a rare tumour of infancy. Report of five cases. (23157779)
2012
8
Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. (20937573)
2011
9
Key cytological findings in FNA from infantile digital fibromatosis. (21986179)
2011
10
Infantile digital fibromatosis: our experience and long-term results. (21276743)
2011
11
Congenital infantile digital fibromatosis: a case report and review of the literature. (21139926)
2009
12
Infantile digital fibromatosis. (18812724)
2008
13
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. (18266786)
2008
14
Infantile digital fibromatosis. (18571599)
2008
15
A range of histologic findings in infantile digital fibromatosis. (18304159)
2008
16
Further documentation of spontaneous regression of infantile digital fibromatosis. (17542881)
2007
17
Infantile digital fibromatosis. (17273037)
2007
18
An unusual congenital presentation of infantile digital fibromatosis. (17535189)
2007
19
Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome. (15864382)
2005
20
Intralesional fluorouracil injection in infantile digital fibromatosis. (15897374)
2005
21
Congenital infantile digital fibromatosis. (12220294)
2002
22
Recurrent infantile digital fibromatosis--a rare entity. (11883128)
2001
23
Infantile digital fibromatosis - a case report. (11164672)
2001
24
Infantile digital fibromatosis: an unusual localization. (11584416)
2001
25
A case of infantile digital fibromatosis with spontaneous regression. (9769598)
1998
26
Infantile digital fibromatosis: a study of the development and regression of cytoplasmic inclusion bodies. (7675776)
1995
27
Recurring infantile digital fibromatosis: report of two cases. (7722838)
1995
28
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. (8172324)
1994
29
Immunohistochemical identification of aggregated actin filaments in formalin-fixed, paraffin-embedded sections. I. A study of infantile digital fibromatosis by a new pretreatment. (1310240)
1992
30
Infantile digital fibromatosis: ultrastructural human papillomavirus and herpes simplex virus DNA observation. (1656415)
1991
31
SH abundant body in infantile digital fibromatosis--a histochemical study on distribution of sulfhydryl groups. (2177484)
1990
32
Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. (1697612)
1990
33
A case of infantile digital fibromatosis showing spontaneous regression. (2667619)
1989
34
Infantile digital fibromatosis-like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings. (2836293)
1988
35
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions. (2827878)
1988
36
Posttraumatic occurrence of infantile digital fibromatosis. A histologic and electron microscopic study. (3740876)
1986
37
Infantile digital fibromatosis. An electron microscopic and immunohistochemical study. (3811906)
1986
38
Infantile digital fibromatosis after web construction in syndactyly. (3020117)
1986
39
Identification of actin microfilaments in the intracytoplasmic inclusions present in recurring infantile digital fibromatosis (Reye tumor). (3029741)
1986
40
Infantile digital fibromatosis occurring outside the digit. (6496846)
1984
41
Infantile digital fibromatosis. (6545884)
1984
42
Infantile digital fibromatosis--a case report: an electron microscope study. (6582225)
1983
43
Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding. (6311399)
1983
44
Infantile digital fibromatosis. Ultrastructural, histochemical, and tissue culture observations. (6253042)
1980
45
Cell culture of infantile digital fibromatosis. (6249721)
1980
46
Infantile digital fibromatosis. (4431801)
1974
47
Infantile digital fibromatosis. Histopathological and electron microscopic study with a review of the literature. (4376326)
1974
48
Infantile digital fibromatosis and aponeurotic fibroma. Case reports of tow rare pseudosarcomas and review of the literature. (5761804)
1969

Variations for Infantile Digital Fibromatosis

About this section

Expression for genes affiliated with Infantile Digital Fibromatosis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Infantile Digital Fibromatosis

Search GEO for disease gene expression data for Infantile Digital Fibromatosis.

Pathways for genes affiliated with Infantile Digital Fibromatosis

About this section
Sources:
50PathCards, 5Cell Signaling Technology, 12EMD Millipore, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome
See all sources

Pathways related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1VIM, DES
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.1VIM, DES
3
Show member pathways
9.1VIM, DES
4
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.1VIM, DES

Compounds for genes affiliated with Infantile Digital Fibromatosis

About this section
Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB, 3BitterDB, 61Tocris Bioscience
See all sources

Compounds related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1orcein459.6VIM, DES
2s 100459.6VIM, DES
3toluidine459.6DES, VIM
4reticulin459.6VIM, DES
5mucicarmine459.6VIM, DES
6phalloidin459.6DES, VIM
7b 723459.5VIM, DES
8gemfibrozil29 45 1111.5VIM, DES
9bezafibrate45 29 1111.5DES, VIM
10acetaldehyde29 45 2411.5VIM, DES
11dermatan sulfate459.5DES, VIM
12fenofibrate45 51 1111.5VIM, DES
13hematoxylin459.5VIM, DES
14ganglioside459.5DES, VIM
15procollagen459.5VIM, DES
16progestin459.5VIM, DES
17azathioprine45 3 51 1112.5DES, VIM
18biotin45 24 1111.5VIM, DES
19adriamycin459.5VIM, DES
20bromodeoxyuridine459.5DES, VIM
21dihydrotestosterone45 29 24 1112.5VIM, DES
22hyaluronic acid45 2410.5DES, VIM
23formaldehyde45 2410.5VIM, DES
24heparan sulfate45 2410.5VIM, DES
2512-o-tetradecanoylphorbol 13-acetate459.5DES, VIM
26methionine459.5VIM, DES
27acetylcholine45 51 29 24 1113.4VIM, DES
28doxorubicin45 51 1111.4DES, VIM
29glycogen45 2410.4VIM, DES
30actinomycin d459.4VIM, DES
31estradiol45 24 1111.4DES, VIM
32paraffin459.4VIM, DES
33proline459.4DES, VIM
34iron45 2410.4VIM, DES
35lysine459.3VIM, DES
36lactate459.3DES, VIM
37creatinine459.3VIM, DES
38heparin45 29 24 1112.2DES, VIM
39adenylate459.2VIM, DES
40cyclic amp45 2410.1VIM, DES
41testosterone45 61 24 1112.1VIM, DES
42progesterone45 29 61 24 1113.0DES, VIM
43h2o2458.8VIM, DES

GO Terms for genes affiliated with Infantile Digital Fibromatosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1VIM, DES

Biological processes related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.1VIM, DES

Molecular functions related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1VIM, DES
2structural constituent of cytoskeletonGO:0052008.8VIM, DES

Products for genes affiliated with Infantile Digital Fibromatosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Infantile Digital Fibromatosis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet