IDF
MCID: INF046
MIFTS: 30

Infantile Digital Fibromatosis (IDF) malady

Skin, Cancer categories

Summaries for Infantile Digital Fibromatosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Infantile digital fibromatosis (also known as an \"Inclusion body fibromatosis,\" \"Infantile digital... more...

MalaCards: Infantile Digital Fibromatosis, also known as asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes, is related to fibromatosis and phyllode tumor. An important gene associated with Infantile Digital Fibromatosis is DES (desmin), and among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Infantile Digital Fibromatosis

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
infantile digital fibromatosis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

infantile digital fibromatosis 43 49 61
asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes 43
recurring digital fibrous tumor of childhood 49
inclusion body fibromatosis 49
reye tumor 49
idf 43


External Ids:

ICD10 via Orphanet26 M72.8
SNOMED-CT via Orphanet58 399903008
UMLS via Orphanet62 C1318562

Related Diseases for Infantile Digital Fibromatosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Infantile Digital Fibromatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1fibromatosis31.6DES, VIM
2phyllode tumor10.4
3benign breast phyllodes tumor10.2
4syndactyly10.2
5n syndrome10.2
6bod syndrome10.2
7terminal osseous dysplasia10.2
8intermittent claudication10.0
9adenomatoid tumor10.0VIM
10myoepithelioma10.0VIM
11perineurioma10.0VIM
12angiosarcoma10.0VIM
13infantile myofibromatosis10.0DES
14epidermolysis bullosa simplex10.0DES
15lymphangioleiomyomatosis10.0DES
16lipoma10.0DES
17medulloblastoma10.0DES
18epithelioid leiomyosarcoma10.0DES, VIM
19mesenchymal chondrosarcoma10.0VIM, DES
20pseudosarcomatous fibromatosis10.0DES, VIM
21spindle cell carcinoma10.0VIM, DES
22alveolar soft part sarcoma10.0DES, VIM
23spindle cell sarcoma10.0DES, VIM
24fibrous histiocytoma10.0DES, VIM
25endometrial stromal sarcoma10.0DES, VIM
26sex cord-gonadal stromal tumor10.0VIM, DES
27malignant mixed mullerian tumor10.0VIM, DES
28glomus tumor10.0DES, VIM
29abrikosov's tumor10.0VIM, DES
30giant cell tumor10.0VIM, DES
31sertoli cell tumor10.0DES, VIM
32malignant fibroxanthoma10.0VIM, DES
33pleomorphic adenoma10.0VIM, DES
34dermatofibrosarcoma protuberans10.0DES, VIM
35granular cell tumor10.0DES, VIM
36synovial sarcoma10.0DES, VIM
37hemangiopericytoma10.0VIM, DES
38smooth muscle tumor10.0DES, VIM
39neurilemmoma10.0DES, VIM
40angiomyolipoma10.0VIM, DES
41benign mesothelioma10.0DES, VIM
42rhabdoid tumor10.0DES, VIM
43peripheral primitive neuroectodermal tumor10.0DES, VIM
44chordoma10.0DES, VIM
45leiomyosarcoma10.0DES, VIM
46liposarcoma10.0DES, VIM
47gastrointestinal stromal tumor10.0DES, VIM
48malignant mesothelioma10.0VIM, DES
49chondrosarcoma10.0DES, VIM
50fibrosarcoma10.0DES, VIM

Graphical network of the top 20 diseases related to Infantile Digital Fibromatosis:



Diseases related to infantile digital fibromatosis

Clinical Features for Infantile Digital Fibromatosis

Drugs & Therapeutics for Infantile Digital Fibromatosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Infantile Digital Fibromatosis

Drug clinical trials:

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Genetic Tests for Infantile Digital Fibromatosis

Anatomical Context for Infantile Digital Fibromatosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Infantile Digital Fibromatosis:

33
Breast

Animal Models for Infantile Digital Fibromatosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Infantile Digital Fibromatosis

Sources:
51PubMed
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Articles related to Infantile Digital Fibromatosis:

(show all 50)
idTitleAuthorsYear
1
A case of infantile digital fibromatosis: differential diagnosis and treatment. (23330824)
2014
2
Infantile digital fibromatosis. (23241193)
2013
3
Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis. (24117680)
2013
4
Diagnosis and treatment of digitocutaneous dysplasia, a rare infantile digital fibromatosis: a case report. (24426970)
2013
5
Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement. (23716832)
2013
6
Case report of an ulcerated infantile digital fibromatosis in an older child. The lump to spot in the child's hand (a spot not to lump in with the others). (23578982)
2013
7
Infantile digital fibromatosis: a rare tumour of infancy. Report of five cases. (23157779)
2012
8
Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. (20937573)
2011
9
Key cytological findings in FNA from infantile digital fibromatosis. (21986179)
2011
10
Infantile digital fibromatosis: our experience and long-term results. (21276743)
2011
11
Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up. (18830128)
2009
12
Congenital infantile digital fibromatosis: a case report and review of the literature. (21139926)
2009
13
Infantile digital fibromatosis. (18812724)
2008
14
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. (18266786)
2008
15
Infantile digital fibromatosis. (18571599)
2008
16
A range of histologic findings in infantile digital fibromatosis. (18304159)
2008
17
Further documentation of spontaneous regression of infantile digital fibromatosis. (17542881)
2007
18
Infantile digital fibromatosis. (17273037)
2007
19
An unusual congenital presentation of infantile digital fibromatosis. (17535189)
2007
20
Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome. (15864382)
2005
21
Intralesional fluorouracil injection in infantile digital fibromatosis. (15897374)
2005
22
Congenital infantile digital fibromatosis. (12220294)
2002
23
Recurrent infantile digital fibromatosis--a rare entity. (11883128)
2001
24
Infantile digital fibromatosis - a case report. (11164672)
2001
25
Infantile digital fibromatosis: an unusual localization. (11584416)
2001
26
A case of infantile digital fibromatosis with spontaneous regression. (9769598)
1998
27
Infantile digital fibromatosis: a study of the development and regression of cytoplasmic inclusion bodies. (7675776)
1995
28
Recurring infantile digital fibromatosis: report of two cases. (7722838)
1995
29
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. (8172324)
1994
30
Immunohistochemical identification of aggregated actin filaments in formalin-fixed, paraffin-embedded sections. I. A study of infantile digital fibromatosis by a new pretreatment. (1310240)
1992
31
Infantile digital fibromatosis: ultrastructural human papillomavirus and herpes simplex virus DNA observation. (1656415)
1991
32
SH abundant body in infantile digital fibromatosis--a histochemical study on distribution of sulfhydryl groups. (2177484)
1990
33
Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. (1697612)
1990
34
A case of infantile digital fibromatosis showing spontaneous regression. (2667619)
1989
35
Infantile digital fibromatosis-like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings. (2836293)
1988
36
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions. (2827878)
1988
37
Posttraumatic occurrence of infantile digital fibromatosis. A histologic and electron microscopic study. (3740876)
1986
38
Infantile digital fibromatosis. An electron microscopic and immunohistochemical study. (3811906)
1986
39
Infantile digital fibromatosis after web construction in syndactyly. (3020117)
1986
40
Identification of actin microfilaments in the intracytoplasmic inclusions present in recurring infantile digital fibromatosis (Reye tumor). (3029741)
1986
41
Infantile digital fibromatosis occurring outside the digit. (6496846)
1984
42
Infantile digital fibromatosis. (6545884)
1984
43
Infantile digital fibromatosis--a case report: an electron microscope study. (6582225)
1983
44
Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding. (6311399)
1983
45
Ultrastructural histochemistry of infantile digital fibromatosis. (6270858)
1981
46
Infantile digital fibromatosis. Ultrastructural, histochemical, and tissue culture observations. (6253042)
1980
47
Cell culture of infantile digital fibromatosis. (6249721)
1980
48
Infantile digital fibromatosis. (4431801)
1974
49
Infantile digital fibromatosis. Histopathological and electron microscopic study with a review of the literature. (4376326)
1974
50
Infantile digital fibromatosis and aponeurotic fibroma. Case reports of tow rare pseudosarcomas and review of the literature. (5761804)
1969

Genetic Variations for Infantile Digital Fibromatosis

Expression for genes affiliated with Infantile Digital Fibromatosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infantile Digital Fibromatosis

Search GEO for disease gene expression data for Infantile Digital Fibromatosis.

Pathways for genes affiliated with Infantile Digital Fibromatosis

Sources:
4Cell Signaling Technology, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome
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Pathways related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1DES, VIM
2
Hide members
9.1DES, VIM
3
Hide members
9.1DES, VIM
49.1DES, VIM

Compounds for genes affiliated with Infantile Digital Fibromatosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1orcein459.5VIM, DES
2s 100459.5VIM, DES
3toluidine459.5VIM, DES
4reticulin459.5VIM, DES
5mucicarmine459.5DES, VIM
6phalloidin459.5DES, VIM
7b 723459.5DES, VIM
8gemfibrozil45 29 1111.5VIM, DES
9bezafibrate45 29 1111.5VIM, DES
10acetaldehyde45 29 2411.5DES, VIM
11fenofibrate45 50 1111.5DES, VIM
12hematoxylin459.5DES, VIM
13ganglioside459.5DES, VIM
14procollagen459.5VIM, DES
15progestin459.5VIM, DES
16azathioprine45 50 2 1112.5VIM, DES
17biotin45 11 2411.4VIM, DES
18adriamycin459.4VIM, DES
19bromodeoxyuridine459.4DES, VIM
20dihydrotestosterone45 29 11 2412.4DES, VIM
21hyaluronic acid45 2410.4VIM, DES
22formaldehyde45 2410.4DES, VIM
23heparan sulfate45 2410.4VIM, DES
2412-o-tetradecanoylphorbol 13-acetate459.4DES, VIM
25methionine459.3VIM, DES
26doxorubicin45 50 1111.3DES, VIM
27glycogen45 2410.3DES, VIM
28actinomycin d459.2VIM, DES
29estradiol45 11 2411.2DES, VIM
30paraffin459.1DES, VIM
31lysine459.1DES, VIM
32proline459.0VIM, DES
33iron45 249.8VIM, DES

GO Terms for genes affiliated with Infantile Digital Fibromatosis

Sources:
16Gene Ontology
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Cellular components related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1DES, VIM

Biological processes related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.1DES, VIM

Molecular functions related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.1DES, VIM

Products for genes affiliated with Infantile Digital Fibromatosis

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Sources for Infantile Digital Fibromatosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet