IDF
MCID: INF046
MIFTS: 38

Infantile Digital Fibromatosis (IDF) malady

Rare diseases, Skin diseases, Cancer diseases categories

Summaries for Infantile Digital Fibromatosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Infantile digital fibromatosis (also known as an \"Inclusion body fibromatosis,\" \"Infantile digital... more...

MalaCards: Infantile Digital Fibromatosis, also known as asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes, is related to fibromatosis and fibroma. An important gene associated with Infantile Digital Fibromatosis is DES (desmin), and among its related pathways are Cytoskeletal Signaling and Cytoplasmic microtubules. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Aliases & Classifications for Infantile Digital Fibromatosis

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Sources:
44NIH Rare Diseases, 50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

50
infantile digital fibromatosis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

infantile digital fibromatosis 44 50 63
asymptomatic nodular proliferation of fibrous tissue on the dorsal and lateral aspects of the fingers or toes 44
recurring digital fibrous tumor of childhood 50
inclusion body fibromatosis 50
reye tumor 50
idf 44


External Ids:

ICD10 via Orphanet27 M72.8
SNOMED-CT via Orphanet60 399903008
UMLS via Orphanet64 C1318562

Related Diseases for Infantile Digital Fibromatosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Infantile Digital Fibromatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1fibromatosis31.6VIM, DES
2fibroma30.4DES, VIM
3phyllode tumor10.4
4syndactyly10.2
5herpes simplex10.2
6terminal osseous dysplasia10.2
7adenomatoid tumor10.1VIM
8infantile myofibromatosis10.1DES
9intermittent claudication10.0
10diabetes mellitus10.0
11type 2 diabetes mellitus10.0
12epithelioid leiomyosarcoma10.0VIM, DES
13mesenchymal chondrosarcoma10.0VIM, DES
14pseudosarcomatous fibromatosis10.0DES, VIM
15spindle cell carcinoma10.0DES, VIM
16alveolar soft part sarcoma10.0VIM, DES
17spindle cell sarcoma10.0VIM, DES
18sertoli cell tumor10.0VIM, DES
19granular cell tumor10.0DES, VIM
20dermatofibrosarcoma protuberans10.0DES, VIM
21fibrous histiocytoma10.0DES, VIM
22endometrial stromal sarcoma10.0VIM, DES
23rhabdoid tumor10.0DES, VIM
24sex cord-gonadal stromal tumor10.0VIM, DES
25hemangiopericytoma10.0VIM, DES
26angiomyolipoma10.0VIM, DES
27glomus tumor10.0DES, VIM
28malignant mixed mullerian tumor10.0DES, VIM
29chordoma10.0DES, VIM
30smooth muscle tumor10.0VIM, DES
31abrikosov's tumor10.0DES, VIM
32giant cell tumor10.0DES, VIM
33pleomorphic adenoma10.0VIM, DES
34malignant fibroxanthoma10.0VIM, DES
35liposarcoma10.0DES, VIM
36synovial sarcoma10.0VIM, DES
37gastrointestinal stromal tumor10.0DES, VIM
38leiomyosarcoma10.0VIM, DES
39neurilemmoma10.0VIM, DES
40malignant mesothelioma10.0DES, VIM
41benign mesothelioma10.0VIM, DES
42leiomyoma10.0VIM, DES
43peripheral primitive neuroectodermal tumor10.0VIM, DES
44chondrosarcoma10.0VIM, DES
45rhabdomyosarcoma10.0DES, VIM
46sarcoma10.0VIM, DES
47wilms tumor10.0VIM, DES
48fibrosarcoma9.9DES, VIM

Graphical network of the top 20 diseases related to Infantile Digital Fibromatosis:



Diseases related to infantile digital fibromatosis

Symptoms for Infantile Digital Fibromatosis

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Drugs & Therapeutics for Infantile Digital Fibromatosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Infantile Digital Fibromatosis

Drug clinical trials:

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Search CenterWatch for Infantile Digital Fibromatosis

Genetic Tests for Infantile Digital Fibromatosis

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Anatomical Context for Infantile Digital Fibromatosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Infantile Digital Fibromatosis:

34
Skin, Breast

Animal Models for Infantile Digital Fibromatosis or affiliated genes

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Publications for Infantile Digital Fibromatosis

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53PubMed
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Articles related to Infantile Digital Fibromatosis:

(show all 48)
idTitleAuthorsYear
1
A case of infantile digital fibromatosis: differential diagnosis and treatment. (23330824)
2014
2
Infantile digital fibromatosis. (23241193)
2013
3
Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis. (24117680)
2013
4
Diagnosis and treatment of digitocutaneous dysplasia, a rare infantile digital fibromatosis: a case report. (24426970)
2013
5
Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement. (23716832)
2013
6
Case report of an ulcerated infantile digital fibromatosis in an older child. The lump to spot in the child's hand (a spot not to lump in with the others). (23578982)
2013
7
Infantile digital fibromatosis: a rare tumour of infancy. Report of five cases. (23157779)
2012
8
Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. (20937573)
2011
9
Key cytological findings in FNA from infantile digital fibromatosis. (21986179)
2011
10
Infantile digital fibromatosis: our experience and long-term results. (21276743)
2011
11
Congenital infantile digital fibromatosis: a case report and review of the literature. (21139926)
2009
12
Infantile digital fibromatosis. (18812724)
2008
13
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. (18266786)
2008
14
Infantile digital fibromatosis. (18571599)
2008
15
A range of histologic findings in infantile digital fibromatosis. (18304159)
2008
16
Further documentation of spontaneous regression of infantile digital fibromatosis. (17542881)
2007
17
Infantile digital fibromatosis. (17273037)
2007
18
An unusual congenital presentation of infantile digital fibromatosis. (17535189)
2007
19
Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome. (15864382)
2005
20
Intralesional fluorouracil injection in infantile digital fibromatosis. (15897374)
2005
21
Congenital infantile digital fibromatosis. (12220294)
2002
22
Recurrent infantile digital fibromatosis--a rare entity. (11883128)
2001
23
Infantile digital fibromatosis - a case report. (11164672)
2001
24
Infantile digital fibromatosis: an unusual localization. (11584416)
2001
25
A case of infantile digital fibromatosis with spontaneous regression. (9769598)
1998
26
Infantile digital fibromatosis: a study of the development and regression of cytoplasmic inclusion bodies. (7675776)
1995
27
Recurring infantile digital fibromatosis: report of two cases. (7722838)
1995
28
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. (8172324)
1994
29
Immunohistochemical identification of aggregated actin filaments in formalin-fixed, paraffin-embedded sections. I. A study of infantile digital fibromatosis by a new pretreatment. (1310240)
1992
30
Infantile digital fibromatosis: ultrastructural human papillomavirus and herpes simplex virus DNA observation. (1656415)
1991
31
SH abundant body in infantile digital fibromatosis--a histochemical study on distribution of sulfhydryl groups. (2177484)
1990
32
Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. (1697612)
1990
33
A case of infantile digital fibromatosis showing spontaneous regression. (2667619)
1989
34
Infantile digital fibromatosis-like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings. (2836293)
1988
35
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions. (2827878)
1988
36
Posttraumatic occurrence of infantile digital fibromatosis. A histologic and electron microscopic study. (3740876)
1986
37
Infantile digital fibromatosis. An electron microscopic and immunohistochemical study. (3811906)
1986
38
Infantile digital fibromatosis after web construction in syndactyly. (3020117)
1986
39
Identification of actin microfilaments in the intracytoplasmic inclusions present in recurring infantile digital fibromatosis (Reye tumor). (3029741)
1986
40
Infantile digital fibromatosis occurring outside the digit. (6496846)
1984
41
Infantile digital fibromatosis. (6545884)
1984
42
Infantile digital fibromatosis--a case report: an electron microscope study. (6582225)
1983
43
Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding. (6311399)
1983
44
Infantile digital fibromatosis. Ultrastructural, histochemical, and tissue culture observations. (6253042)
1980
45
Cell culture of infantile digital fibromatosis. (6249721)
1980
46
Infantile digital fibromatosis. (4431801)
1974
47
Infantile digital fibromatosis. Histopathological and electron microscopic study with a review of the literature. (4376326)
1974
48
Infantile digital fibromatosis and aponeurotic fibroma. Case reports of tow rare pseudosarcomas and review of the literature. (5761804)
1969

Variations for Infantile Digital Fibromatosis

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Expression for genes affiliated with Infantile Digital Fibromatosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infantile Digital Fibromatosis

Search GEO for disease gene expression data for Infantile Digital Fibromatosis.

Pathways for genes affiliated with Infantile Digital Fibromatosis

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Sources:
51PathCards, 5Cell Signaling Technology, 13EMD Millipore, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1VIM, DES
2
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.1VIM, DES
3
Show member pathways
9.1VIM, DES
4
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.1VIM, DES

Compounds for genes affiliated with Infantile Digital Fibromatosis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1orcein469.6VIM, DES
2s 100469.6VIM, DES
3toluidine469.6DES, VIM
4reticulin469.6VIM, DES
5mucicarmine469.6VIM, DES
6phalloidin469.6DES, VIM
7b 723469.5VIM, DES
8gemfibrozil30 46 1211.5VIM, DES
9bezafibrate46 30 1211.5DES, VIM
10acetaldehyde30 46 2511.5VIM, DES
11dermatan sulfate469.5DES, VIM
12fenofibrate46 52 1211.5VIM, DES
13hematoxylin469.5VIM, DES
14ganglioside469.5DES, VIM
15procollagen469.5VIM, DES
16progestin469.5VIM, DES
17azathioprine46 3 52 1212.5DES, VIM
18biotin46 25 1211.5VIM, DES
19adriamycin469.5VIM, DES
20bromodeoxyuridine469.5DES, VIM
21dihydrotestosterone46 30 25 1212.5VIM, DES
22hyaluronic acid46 2510.5DES, VIM
23formaldehyde46 2510.5VIM, DES
24heparan sulfate46 2510.5VIM, DES
2512-o-tetradecanoylphorbol 13-acetate469.5DES, VIM
26methionine469.5VIM, DES
27acetylcholine46 52 30 25 1213.4VIM, DES
28doxorubicin46 52 1211.4DES, VIM
29glycogen46 2510.4VIM, DES
30actinomycin d469.4VIM, DES
31estradiol46 25 1211.4DES, VIM
32paraffin469.4VIM, DES
33proline469.4DES, VIM
34iron46 2510.4VIM, DES
35lysine469.3VIM, DES
36lactate469.3DES, VIM
37creatinine469.3VIM, DES
38heparin46 30 25 1212.2DES, VIM
39adenylate469.2VIM, DES
40cyclic amp46 2510.1VIM, DES
41testosterone46 62 25 1212.1VIM, DES
42progesterone46 30 62 25 1213.0DES, VIM
43h2o2468.8VIM, DES

GO Terms for genes affiliated with Infantile Digital Fibromatosis

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17Gene Ontology
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Cellular components related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1VIM, DES

Biological processes related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.1VIM, DES

Molecular functions related to Infantile Digital Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1VIM, DES
2structural constituent of cytoskeletonGO:0052008.8VIM, DES

Products for genes affiliated with Infantile Digital Fibromatosis

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  • Antibodies
  • Proteins
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Sources for Infantile Digital Fibromatosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet