MCID: INF019
MIFTS: 30

Infectious Anterior Uveitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Infectious Anterior Uveitis

Aliases & Descriptions for Infectious Anterior Uveitis:

Name: Infectious Anterior Uveitis 12 56 14
Secondary Infected Iridocyclitis 12 69
Secondary Iridocyclitis, Infectious 12
Infectious Secondary Iridocyclitis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9389
ICD10 33 H20.03
ICD9CM 35 364.03
SNOMED-CT 64 193487008 89114005
Orphanet 56 ORPHA279922
ICD10 via Orphanet 34 H20.0 H20.1 H20.2 more
UMLS 69 C0154911

Summaries for Infectious Anterior Uveitis

MalaCards based summary : Infectious Anterior Uveitis, also known as secondary infected iridocyclitis, is related to basilar artery insufficiency and uveitis. An important gene associated with Infectious Anterior Uveitis is SOCS1 (Suppressor Of Cytokine Signaling 1), and among its related pathways/superpathways are IL-2 Pathway and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Ganciclovir and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is liver/biliary system.

Related Diseases for Infectious Anterior Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Infectious Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 basilar artery insufficiency 9.9 SOCS1 SOCS3
2 uveitis 9.7
3 anterior uveitis 9.7
4 allergic asthma 9.3 MRAP SOCS1 SOCS3 STAT1

Symptoms & Phenotypes for Infectious Anterior Uveitis

MGI Mouse Phenotypes related to Infectious Anterior Uveitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.8 SOCS1 SOCS3 STAT1

Drugs & Therapeutics for Infectious Anterior Uveitis

Drugs for Infectious Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
2
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
3 Anti-Infective Agents Phase 4,Phase 3
4 Antiviral Agents Phase 4,Phase 3
5 Ganciclovir triphosphate Phase 4
6 Nucleic Acid Synthesis Inhibitors Phase 4
7 Ophthalmic Solutions Phase 4
8 Pharmaceutical Solutions Phase 4
9 Tetrahydrozoline Phase 4
10 Antirheumatic Agents Phase 4,Phase 2
11 Dermatologic Agents Phase 4,Phase 2
12 Immunosuppressive Agents Phase 4,Phase 2
13
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
15 Acyclovir Phase 3
16 Antiemetics Phase 3,Phase 1,Phase 2
17 Autonomic Agents Phase 3,Phase 1,Phase 2
18 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
19 Hormones Phase 3,Phase 2,Phase 1
20 Methylprednisolone acetate Phase 3
21 Methylprednisolone Hemisuccinate Phase 3
22 Neuroprotective Agents Phase 3
23 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
24 Prednisolone acetate Phase 3
25 Prednisolone hemisuccinate Phase 3
26 Prednisolone phosphate Phase 3
27 Protective Agents Phase 3
28
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
29
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
30
Infliximab Approved Phase 2 170277-31-3
31
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
32 Anti-Inflammatory Agents Phase 2,Phase 1
33 Analgesics Phase 2
34 Analgesics, Non-Narcotic Phase 2
35 Interleukin-2 Phase 2
36 Alkylating Agents Phase 2
37 Antineoplastic Agents, Alkylating Phase 2
38 Antineoplastic Agents, Hormonal Phase 2,Phase 1
39 glucocorticoids Phase 2,Phase 1
40 Hormone Antagonists Phase 2,Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
42 Antibodies Phase 1
43 Antibodies, Monoclonal Phase 1
44 Immunoglobulins Phase 1

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4
2 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4
3 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3
4 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3
5 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2
6 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2
7 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
8 A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease Withdrawn NCT01211977 Phase 1, Phase 2
9 Efalizumab to Treat Uveitis Completed NCT00280826 Phase 1
10 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1
11 Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis Unknown status NCT02222857
12 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529
13 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438
14 Infectious Causes of Uveitis Completed NCT00676624

Search NIH Clinical Center for Infectious Anterior Uveitis

Genetic Tests for Infectious Anterior Uveitis

Anatomical Context for Infectious Anterior Uveitis

MalaCards organs/tissues related to Infectious Anterior Uveitis:

39
Eye

Publications for Infectious Anterior Uveitis

Articles related to Infectious Anterior Uveitis:

id Title Authors Year
1
Current diagnostic approaches to infectious anterior uveitis. ( 21897147 )
2011

Variations for Infectious Anterior Uveitis

Expression for Infectious Anterior Uveitis

Search GEO for disease gene expression data for Infectious Anterior Uveitis.

Pathways for Infectious Anterior Uveitis

Pathways related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 SOCS1 SOCS3 STAT1
2
Show member pathways
12.58 SOCS1 SOCS3 STAT1
3
Show member pathways
12.47 SOCS1 SOCS3 STAT1
4 12.26 SOCS1 SOCS3 STAT1
5
Show member pathways
12.24 SOCS1 SOCS3 STAT1
6
Show member pathways
12.2 SOCS1 SOCS3 STAT1
7
Show member pathways
12.11 SOCS1 SOCS3 STAT1
8
Show member pathways
11.94 SOCS1 SOCS3 STAT1
9
Show member pathways
11.93 SOCS1 STAT1
10
Show member pathways
11.86 SOCS1 STAT1
11
Show member pathways
11.86 SOCS1 SOCS3 STAT1
12
Show member pathways
11.81 SOCS1 SOCS3 STAT1
13 11.79 SOCS1 SOCS3
14 11.79 SOCS1 SOCS3 STAT1
15 11.76 SOCS3 STAT1
16 11.74 SOCS1 SOCS3 STAT1
17
Show member pathways
11.7 SOCS1 STAT1
18 11.64 SOCS1 SOCS3 STAT1
19
Show member pathways
11.62 SOCS1 SOCS3
20
Show member pathways
11.62 SOCS1 SOCS3
21
Show member pathways
11.6 SOCS1 STAT1
22
Show member pathways
11.57 SOCS3 STAT1
23
Show member pathways
11.53 SOCS1 SOCS3 STAT1
24 11.44 SOCS1 SOCS3 STAT1
25 11.42 SOCS1 SOCS3
26
Show member pathways
11.38 SOCS3 STAT1
27 11.25 SOCS3 STAT1
28 11.17 SOCS1 SOCS3 STAT1
29 10.97 SOCS1 SOCS3 STAT1
30
Show member pathways
10.94 SOCS1 SOCS3 STAT1
31
Show member pathways
10.92 SOCS3 STAT1
32 10.82 SOCS3 STAT1
33 10.74 SOCS1 SOCS3 STAT1
34 10.37 SOCS1 SOCS3 STAT1

GO Terms for Infectious Anterior Uveitis

Biological processes related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.49 SOCS1 SOCS3
2 negative regulation of protein kinase activity GO:0006469 9.48 SOCS1 SOCS3
3 regulation of growth GO:0040008 9.46 SOCS1 SOCS3
4 negative regulation of signal transduction GO:0009968 9.43 SOCS1 SOCS3
5 negative regulation of JAK-STAT cascade GO:0046426 9.4 SOCS1 SOCS3
6 negative regulation of insulin receptor signaling pathway GO:0046627 9.37 SOCS1 SOCS3
7 negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 9.32 SOCS1 SOCS3
8 negative regulation of tyrosine phosphorylation of Stat3 protein GO:0042518 9.26 SOCS1 SOCS3
9 negative regulation of tyrosine phosphorylation of Stat1 protein GO:0042512 9.16 SOCS1 SOCS3
10 JAK-STAT cascade GO:0007259 9.13 SOCS1 SOCS3 STAT1
11 regulation of interferon-gamma-mediated signaling pathway GO:0060334 8.8 SOCS1 SOCS3 STAT1

Molecular functions related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase inhibitor activity GO:0004860 8.62 SOCS1 SOCS3

Sources for Infectious Anterior Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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