MCID: INF019
MIFTS: 31

Infectious Anterior Uveitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Infectious Anterior Uveitis

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Sources:
11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 53Orphanet, 61SNOMED-CT, 67UMLS
See all MalaCards sources

Aliases & Descriptions for Infectious Anterior Uveitis:

Name: Infectious Anterior Uveitis 11 53 13
Secondary Infected Iridocyclitis 11 67
 
Secondary Iridocyclitis, Infectious 11
Infectious Secondary Iridocyclitis 11

Classifications:

Orphanet: 53 
Rare eye diseases


External Ids:

Disease Ontology11 DOID:9389
ICD1029 H20.03
ICD9CM31 364.03
SNOMED-CT61 193487008, 89114005
Orphanet53 ORPHA279922
ICD10 via Orphanet30 H20.0, H20.1, H20.2 H20.8, H20.9, more

Summaries for Infectious Anterior Uveitis

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MalaCards based summary: Infectious Anterior Uveitis, also known as secondary infected iridocyclitis, is related to uveitis and anterior uveitis. An important gene associated with Infectious Anterior Uveitis is SOCS1 (Suppressor Of Cytokine Signaling 1), and among its related pathways are Insulin Signaling and Immune response IL-2 activation and signaling pathway. Affiliated tissues include eye, endothelial and t cells, and related mouse phenotype liver/biliary system.

Related Diseases for Infectious Anterior Uveitis

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Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
infectious anterior uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Infectious Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1uveitis9.7
2anterior uveitis9.7

Symptoms for Infectious Anterior Uveitis

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Drugs & Therapeutics for Infectious Anterior Uveitis

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Drugs for Infectious Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ganciclovirapproved, investigationalPhase 415182410-32-03454
Synonyms:
106931-35-5
107910-75-8 (mono-hydrochloride salt)
2'-NDG
2'-Nor-2'-deoxyguanosine
2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol
2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-3H-purin-6(9H)-one
2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-ol
2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
2-amino-9-(2-Hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-(2-hydroxy-1-hydroxymethylethoxymethyl)-6,9-dihydro-1H-6-purinone
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one
82410-32-0
86357-12-2
9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
96551-29-0
AC-12604
AC1L1FZ2
AC1Q52OB
AKOS004119898
BB_NC-1042
BIDD:GT0783
BIOLF-62
BPBio1_000877
BSPBio_000797
BW 759
BW 759U
BW-759U
BW-795
BW-B 759U
Biolf 62
CAS-82410-32-0
CCRIS 9212
CHEBI:465284
CHEMBL182
CID3454
CPD000058324
Citovirax
Cymevan
Cymeven
Cymevene
Cytovene
Cytovene (TN)
Cytovene-IV
D00333
DB01004
DRG-0018
EU-0100539
 
G 2536
G2536_SIGMA
GA2
GANCICLOVIR SODIUM
GCV & 1110U81
GCV & MSL
Ganciclovir
Ganciclovir & C34-dgA immunotoxin
Ganciclovir & D5-dgA immunotoxin
Ganciclovir (JAN/USP/INN)
Ganciclovir [USAN:INN:BAN:JAN]
Ganciclovirum
Ganciclovirum [Latin]
Gancyclovir
Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- and MSL, neutralizing monoclonal antibody
HHEMG
HMS1570H19
HMS2090K08
HSDB 6512
Hydroxyacyclovir
I07-0010
IN1478
LS-73939
Lopac-G-2536
Lopac0_000539
MB3795
MLS000028481
MLS001077349
MolPort-000-758-398
MolPort-002-507-301
NCGC00015471-01
NCGC00015471-02
NCGC00015471-03
NCGC00015471-06
NCGC00093928-01
NCGC00093928-02
NCGC00168567-01
PDSP1_000816
PDSP2_000803
Prestwick0_000839
Prestwick1_000839
Prestwick2_000839
Prestwick3_000839
Prestwick_1068
RS-21592
SAM002548936
SMP2_000038
SMR000058324
SPBio_002718
ST-605
STK801910
UNII-P9G3CKZ4P5
Virgan
Vitrasert
Vitrasert (TN)
ZINC00001505
Zirgan
ganciclovir
nchembio.87-comp3
2Antiviral AgentsPhase 4, Phase 39732
3Anti-Infective AgentsPhase 4, Phase 321402
4Nucleic Acid Synthesis InhibitorsPhase 44855
5Ganciclovir triphosphatePhase 4151
6Pharmaceutical SolutionsPhase 47793
7TetrahydrozolinePhase 4593
8Ophthalmic SolutionsPhase 41092
9
Prednisoloneapproved, vet_approvedPhase 3115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
10
Methylprednisoloneapproved, vet_approvedPhase 3115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
11Peripheral Nervous System AgentsPhase 3, Phase 2, Phase 122776
12Prednisolone acetatePhase 31153
13Protective AgentsPhase 37190
14Prednisolone phosphatePhase 31153
15Prednisolone hemisuccinatePhase 31153
16Neuroprotective AgentsPhase 31672
17Methylprednisolone HemisuccinatePhase 31153
18AntiemeticsPhase 3, Phase 1, Phase 23888
19AcyclovirPhase 3178
20Autonomic AgentsPhase 3, Phase 1, Phase 29774
21Gastrointestinal AgentsPhase 3, Phase 1, Phase 28109
22HormonesPhase 3, Phase 1, Phase 213979
23Methylprednisolone acetatePhase 31153
24
AldesleukinapprovedPhase 239785898-30-2, 110942-02-4
Synonyms:
125-L-serine-2-133-interleukin 2 (human reduced)
 
Interleukin-2 aldesleukin
Interleukin-2(2-133),125-ser
Recombinant interleukin-2 human
25Anti-Inflammatory AgentsPhase 1, Phase 210355
26Analgesics, Non-NarcoticPhase 26260
27AnalgesicsPhase 211287
28Interleukin-2Phase 2553
29ImmunoglobulinsPhase 16045
30AntibodiesPhase 16045
31Antibodies, MonoclonalPhase 13795

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / EndotheliitisRecruitingNCT02943057Phase 4
2Methotrexate in the Treatment of Axial SpondyloarthritisWithdrawnNCT00298012Phase 4
3Herpetic Eye Disease Study (HEDS) IUnknown statusNCT00000138Phase 3
4Herpetic Eye Disease Study (HEDS) IICompletedNCT00000139Phase 3
5Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory DiseasesRecruitingNCT01988506Phase 2
6A Phase I/IIa Study for the Treatment of Uveitis With IontophoresisWithdrawnNCT00499551Phase 1, Phase 2
7A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's DiseaseWithdrawnNCT01211977Phase 1, Phase 2
8Efalizumab to Treat UveitisCompletedNCT00280826Phase 1
9Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory ConditionsWithdrawnNCT02042027Phase 1
10Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal NecrosisUnknown statusNCT02222857
11Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / EndotheliitisCompletedNCT01647529
12Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis UveitisCompletedNCT02843438
13Infectious Causes of UveitisCompletedNCT00676624

Search NIH Clinical Center for Infectious Anterior Uveitis

Genetic Tests for Infectious Anterior Uveitis

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Anatomical Context for Infectious Anterior Uveitis

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MalaCards organs/tissues related to Infectious Anterior Uveitis:

35
Eye, Endothelial, T cells

Animal Models for Infectious Anterior Uveitis or affiliated genes

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MGI Mouse Phenotypes related to Infectious Anterior Uveitis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5SOCS1, SOCS3, STAT1

Publications for Infectious Anterior Uveitis

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Articles related to Infectious Anterior Uveitis:

idTitleAuthorsYear
1
Current diagnostic approaches to infectious anterior uveitis. (21897147)
2011

Variations for Infectious Anterior Uveitis

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Expression for genes affiliated with Infectious Anterior Uveitis

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Search GEO for disease gene expression data for Infectious Anterior Uveitis.

Pathways for genes affiliated with Infectious Anterior Uveitis

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Pathways related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.3SOCS1, SOCS3
2
Show member pathways
9.3SOCS1, SOCS3
3
Show member pathways
9.3SOCS1, SOCS3
49.3SOCS1, SOCS3
5
Show member pathways
9.1SOCS1, STAT1
6
Show member pathways
9.1SOCS1, STAT1
7
Show member pathways
9.1SOCS1, STAT1
8
Show member pathways
9.0SOCS3, STAT1
99.0SOCS3, STAT1
10
Show member pathways
9.0SOCS3, STAT1
119.0SOCS3, STAT1
129.0SOCS3, STAT1
13
Show member pathways
9.0SOCS3, STAT1
14
Show member pathways
9.0SOCS3, STAT1
15
Show member pathways
8.5SOCS1, SOCS3, STAT1
16
Show member pathways
8.5SOCS1, SOCS3, STAT1
178.5SOCS1, SOCS3, STAT1
18
Show member pathways
8.5SOCS1, SOCS3, STAT1
198.5SOCS1, SOCS3, STAT1
208.5SOCS1, SOCS3, STAT1
218.5SOCS1, SOCS3, STAT1
228.5SOCS1, SOCS3, STAT1
23
Show member pathways
8.5SOCS1, SOCS3, STAT1
248.5SOCS1, SOCS3, STAT1
25
Show member pathways
8.5SOCS1, SOCS3, STAT1
26
Show member pathways
8.5SOCS1, SOCS3, STAT1
278.5SOCS1, SOCS3, STAT1
288.5SOCS1, SOCS3, STAT1
29
Show member pathways
8.5SOCS1, SOCS3, STAT1

GO Terms for genes affiliated with Infectious Anterior Uveitis

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Biological processes related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of tyrosine phosphorylation of Stat3 proteinGO:004251810.0SOCS1, SOCS3
2negative regulation of tyrosine phosphorylation of Stat1 proteinGO:004251210.0SOCS1, SOCS3
3negative regulation of insulin receptor signaling pathwayGO:00466279.8SOCS1, SOCS3
4response to progesteroneGO:00325709.8SOCS1, SOCS3
5animal organ regenerationGO:00311009.7SOCS1, SOCS3
6negative regulation of JAK-STAT cascadeGO:00464269.7SOCS1, SOCS3
7cytokine-mediated signaling pathwayGO:00192219.7SOCS1, SOCS3
8response to lipopolysaccharideGO:00324969.6SOCS1, SOCS3
9negative regulation of protein kinase activityGO:00064699.6SOCS1, SOCS3
10regulation of growthGO:00400089.5SOCS1, SOCS3
11response to peptide hormoneGO:00434349.5SOCS1, STAT1
12response to estradiolGO:00323559.4SOCS1, SOCS3
13regulation of interferon-gamma-mediated signaling pathwayGO:00603349.1SOCS1, SOCS3, STAT1
14JAK-STAT cascadeGO:00072599.0SOCS1, SOCS3, STAT1
15response to drugGO:00424938.5SOCS1, SOCS3, STAT1

Molecular functions related to Infectious Anterior Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein kinase inhibitor activityGO:00048609.3SOCS1, SOCS3

Sources for Infectious Anterior Uveitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet