ACS5
MCID: INF030
MIFTS: 65

Infectious Mononucleosis (ACS5) malady

Infectious, Eye, Bone, Fetal, Endocrine categories

Summaries for Infectious Mononucleosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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CDC:3 Epstein-Barr virus, frequently referred to as EBV, is a member of the herpesvirus family and one of the most common human viruses. The virus occurs worldwide, and most people become infected with EBV sometime during their lives. In the United States, as many as 95% of adults between 35 and 40 years of age have been infected. Infants become susceptible to EBV as soon as maternal antibody protection (present at birth) disappears. Many children become infected with EBV, and these infections usually cause no symptoms or are indistinguishable from the other mild, brief illnesses of childhood. In the United States and in other developed countries, many persons are not infected with EBV in their childhood years. When infection with EBV occurs during adolescence or young adulthood, it causes infectious mononucleosis 35% to 50% of the time.

MalaCards: Infectious Mononucleosis, also known as pfeiffer syndrome, is related to crouzon syndrome and saethre-chotzen syndrome, and has symptoms including hypertelorism, flat cheek bones/malar hypoplasia and short neck. An important gene associated with Infectious Mononucleosis is FGFR1 (fibroblast growth factor receptor 1), and among its related pathways are NF-KappaB Family Pathway and Regulation of Actin Cytoskeleton. The compounds SU4984 and pd 161570 have been mentioned in the context of this disorder. Affiliated tissues include pharynx, skin and liver.

Disease Ontology:8 A viral infectious disease that results in inflammation, located in pharynx, has material basis in human herpesvirus 4 and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly.

NIH Rare Diseases:43 Pfeiffer syndrome is a disorder that affects the bones in the skull, hands and feet. signs and symptoms can include craniosynostosis, which prevents normal skull growth and affects the shape of the head and face; distinctive facial features including bulging and wide-set eyes, a high forehead, an underdeveloped upper jaw, and a beaked nose; hearing loss; and dental problems. other features may include broad and deviated thumbs and great toes; brachydactyly; and syndactyly. it is caused by mutations in the fgfr1 or fgfr2 genes and is inherited in an autosomal dominant manner. the syndrome is divided into 3 subtypes (types 1, 2 and 3) based on the presence and severity of signs and symptoms. management typically includes various surgical interventions. last updated: 5/2/2011

MedlinePlus:34 Infectious mononucleosis, or "mono", is an infection usually caused by the epstein-barr virus. the virus spreads through saliva, which is why it's sometimes called "kissing disease." mono occurs most often in teens and young adults. however, you can get it at any age. symptoms of mono include fever sore throat swollen lymph glands sometimes you may also have a swollen spleen. serious problems are rare. a blood test can show if you have mono. most people get better in two to four weeks. however, you may feel tired for a few months afterward. treatment focuses on helping symptoms and includes medicines for pain and fever, warm salt water gargles and plenty of rest and fluids.

Genetics Home Reference:21 Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face. Pfeiffer syndrome also affects bones in the hands and feet.

Wikipedia:64 Infectious mononucleosis (IM; also known as mono, glandular fever, Pfeiffer\'s disease, Filatov\'s... more...

Description from OMIM:47 101600

Aliases & Classifications for Infectious Mononucleosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 9diseasecard, 64Wikipedia, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 47OMIM, 49Orphanet, 35MeSH, 40NCIt, 57SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious, Fetal
Anatomical: Eye, Bone, Endocrine


Characteristics (Orphanet epidemiological data):

49
pfeiffer syndrome:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

infectious mononucleosis 8 10 45 34 61
pfeiffer syndrome 8 9 64 43 22 21 47 45 49
craniofacial-skeletal-dermatologic dysplasia 21 47 61
acs5 43 21 49
pfeiffer type acrocephalosyndactyly 43 61
acrocephalosyndactyly, type v 64 21
noack syndrome 64 21
acrocephalopolysyndactyly type iv 61
gammaherpesviral mononucleosis 8
acrocephalosyndactylia type v 8
acrocephalosyndactyly, type 5 43
acrocephalosyndactyly type 5 49
pfeiffer's disease 8
filatov's disease 8
monocytic angina 8
glandular fever 8
mononucleosis 8
acs v 21


External Ids:

Disease Ontology8 DOID:8568, DOID:14705
NCIt40 C34726
ICD9CM27 075
OMIM47 101600
MESH via Orphanet36 C538582
ICD10 via Orphanet26 Q87.0
SNOMED-CT via Orphanet58 70410008
UMLS via Orphanet62 C2931888
ICD1025 B27, B27.0

Related Diseases for Infectious Mononucleosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Infectious Mononucleosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1crouzon syndrome30.4FGFR1, FGFR2
2saethre-chotzen syndrome30.2FGFR1, FGFR2
3achondroplasia30.0FGFR2
4jackson-weiss syndrome30.0FGFR2, FGFR1
5cleft palate30.0FGFR1, FGFR2
6fg syndrome10.8
7hepatitis c10.5
8tonsillitis10.5
9hepatitis a10.5
10chronic fatigue syndrome10.4
11n syndrome10.4
12winkelman bethge pfeiffer syndrome10.4
13lemierre's syndrome10.4
14acute leukemia10.4
15agammaglobulinemia10.4
16thrombocytopenia10.4
17infectious myocarditis10.4
18cytomegalovirus infection10.4
19pfeiffer syndrome type 110.3
20acalculous cholecystitis10.3
21splenic infarction10.3
22neuronitis10.3
23measles10.3
24arthritis10.3
25splenomegaly10.3
26goodman syndrome10.2
27camptodactyly, fibrous tissue hyperplasia, and skeletal dysplasia10.2
28faces syndrome10.2
29myelitis10.2
30acute monocytic leukemia10.2
31hemophagocytic lymphohistiocytosis10.2
32systemic lupus erythematosus10.2
33pericoronitis10.2
34pharyngitis10.2
35epiglottitis10.2
36acute dacryocystitis10.2
37acute disseminated encephalomyelitis10.2
38parotitis10.2
39adult syndrome10.2
40adult lymphoma10.2
41acute myocarditis10.2
42aplastic anemia10.2
43urticaria10.2
44lymphoproliferative disease, x-linked10.2
45chronic active epstein-barr virus infection10.2
46cytomegalic inclusion disease10.2
47transverse myelitis10.2
48nephritis10.2
49cardiocranial syndrome10.2
50pituitary hormone deficiency, combined 310.2

Graphical network of the top 20 diseases related to Infectious Mononucleosis:



Diseases related to infectious mononucleosis

Clinical Features for Infectious Mononucleosis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

101600

Clinical synopsis from OMIM:

101600

Symptoms:

49 (show all 27)
  • hypertelorism
  • flat cheek bones/malar hypoplasia
  • short neck
  • syndactyly of fingers/interdigital palm
  • ptosis
  • autosomal dominant inheritance
  • high vaulted/narrow palate
  • lordosis
  • splenomegaly
  • hip dislocation/dysplasia/coxa valga/coxa vara/coxa plana
  • prognathism/prognathia
  • broad/bifid thumb
  • short stature/dwarfism/nanism
  • short hand/brachydactyly
  • broad nasal root
  • flat face
  • short philtrum
  • clinodactyly of fifth finger
  • facial structural asymmetry/facial hemiatrophy/facial hemihypertrophy
  • mouth held open
  • high forehead
  • carpal bones fusion/synostosis
  • symphalangy of fingers
  • turricephaly/oxycephaly/acrocephaly
  • fever
  • lymphadenopathy
  • fatigue

Drugs & Therapeutics for Infectious Mononucleosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Infectious Mononucleosis

Drug clinical trials:

Search ClinicalTrials for Infectious Mononucleosis

Search NIH Clinical Center for Infectious Mononucleosis

Search CenterWatch for Infectious Mononucleosis

Genetic Tests for Infectious Mononucleosis

Sources:
22GTR
See all sources

Genetic tests related to Infectious Mononucleosis:

id Genetic test Affiliating Genes
1 Pfeiffer Syndrome22

Anatomical Context for Infectious Mononucleosis

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Infectious Mononucleosis:

33
Skin, Liver, Tongue, Lymph node, Lung, Spleen, Colon, Thyroid, Breast, Tonsil, Monocytes, T cells, B cells

FMA organs/tissues related to Infectious Mononucleosis:

14
Pharynx

Animal Models for Infectious Mononucleosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Infectious Mononucleosis

Sources:
51PubMed
See all sources

Articles related to Infectious Mononucleosis:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Nonsurgical management of complicated splenic rupture in infectious mononucleosis. (23602745)
2013
2
Skin rash in a patient with infectious mononucleosis. (23887989)
2013
3
Pedunculated manifestations of infectious mononucleosis. (22890737)
2012
4
Infectious mononucleosis mimicking lymphoma: distinguishing morphological and immunophenotypic features. (22627742)
2012
5
Mathematical modelling the age dependence of Epstein-Barr virus associated infectious mononucleosis. (21700566)
2012
6
Spontaneous splenic rupture in infectious mononucleosis: case report and review of the literature. (23222107)
2012
7
Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants. (20113421)
2010
8
Epstein-Barr virus-associated infectious mononucleosis and risk of systemic lupus erythematosus. (20488925)
2010
9
Graves' disease associated with infectious mononucleosis due to primary Epstein-Barr virus infection: report of 3 cases. (21139299)
2010
10
Normative spleen size in tall healthy athletes: implications for safe return to contact sports after infectious mononucleosis. (21079435)
2010
11
Infectious mononucleosis hepatitis in young adults: two case reports. (19949739)
2009
12
Acute acalculous cholecystitis with pericholecystitis in a patient with Epstein-Barr Virus infectious mononucleosis. (19179974)
2009
13
Acute disseminated encephalomyelitis following infectious mononucleosis. (17621505)
2007
14
Neutropenic enterocolitis (typhlitis) associated with infectious mononucleosis. (16258744)
2006
15
A prospective follow-up of Epstein-Barr virus LMP1 genotypes in saliva and blood during infectious mononucleosis. (16288374)
2005
16
Role of screening for infectious mononucleosis in patients admitted with isolated, unilateral peritonsillar abscess. (15165311)
2004
17
Massive retropharyngeal lymphadenopathy in an infant: an unusual presentation of infectious mononucleosis. (15667689)
2004
18
Electron microscopic characteristics of peripheral blood lymphocytes in children with infectious mononucleosis. (15455094)
2004
19
Analysis of immune activation and clinical events in acute infectious mononucleosis. (15195244)
2004
20
The nosology of sub-acute and chronic fatigue syndromes that follow infectious mononucleosis. (15259835)
2004
21
High Th1-type cytokine serum levels in patients with infectious mononucleosis. (15745050)
2004
22
Gallbladder wall thickening associated with infectious mononucleosis. (15185034)
2004
23
Cold urticaria and infectious mononucleosis in children. (15617665)
2004
24
Significant liver injury with dual positive IgM antibody to Epstein-Barr virus and cytomegalovirus as a puzzling initial manifestation of infectious mononucleosis. (15168781)
2004
25
Coinfection by multiple strains of Epstein-Barr virus in infectious mononucleosis in immunocompetent patients. (12797591)
2003
26
Infectious mononucleosis presenting as acute hepatitis, with marked leukocytosis and renal involvement. (12696827)
2003
27
Hemolytic uremic syndrome linked to infectious mononucleosis. (13680327)
2003
28
Treatment of severe infectious mononucleosis with famciclovir. (12076068)
2002
29
Florid infectious mononucleosis: clinicopathological correlation in acute tonsillectomy. (12363428)
2002
30
A mouse model for infectious mononucleosis. (12018460)
2002
31
Abdominal pain in acute infectious mononucleosis. (11895827)
2002
32
The management of severe infectious mononucleosis tonsillitis and upper airway obstruction. (11779326)
2001
33
CT diagnosis of a clinically unsuspected acute appendicitis complicating infectious mononucleosis. (11566090)
2001
34
Evaluation of two slide agglutination tests and a novel immunochromatographic assay for rapid diagnosis of infectious mononucleosis. (10973466)
2000
35
Acute renal failure: unusual complication of Epstein-Barr virus-induced infectious mononucleosis. (11096030)
2000
36
Epstein-Barr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells. (10884920)
2000
37
Eruptive acne vulgaris with infectious mononucleosis. (10792257)
2000
38
Infectious mononucleosis: psychological symptoms during acute and subacute phases of illness. (10068917)
1999
39
Infectious mononucleosis and bilateral peritonsillar abscesses resulting in airway obstruction. (10209619)
1998
40
Comparison of lymphocyte subpopulations in the peripheral blood of patients with infectious mononucleosis and human immunodeficiency virus infection: a preliminary report. (10470624)
1998
41
MR findings in isolated oculomotor nerve palsy associated with infectious mononucleosis caused by Epstein-Barr virus infection. (9843247)
1998
42
Infectious mononucleosis hepatitis: report of two patients. (9248190)
1997
43
Orchitis: a rare complication of infectious mononucleosis. (9380458)
1997
44
Postanginal septicemia as a life-threatening complication of infectious mononucleosis. (7620047)
1995
45
T lymphocyte anergy during acute infectious mononucleosis is restricted to the clonotypic receptor activation pathway. (1628427)
1992
46
Detection of a soluble form of the CD30 antigen in sera of patients with lymphoma, adult T-cell leukemia and infectious mononucleosis. (2159438)
1990
47
Infectious mononucleosis presenting as acute intermittent porphyria. (6710211)
1984
48
Atopic dermatitis, eczema herpeticum, infectious mononucleosis, and depressed cell-mediated immunity. (204057)
1978
49
Cerebellar disease in infectious mononucleosis. (5912007)
1966
50
Infectious mononucleosis associated with neuronitis: report of case. (13336132)
1956

Genetic Variations for Infectious Mononucleosis

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Infectious Mononucleosis:

63 (show all 19)
id Symbol AA change Variation SNP ID
1FGFR1p.Pro252ArgVAR_004111
2FGFR2p.Ser252TrpVAR_004115
3FGFR2p.Cys278PheVAR_004121
4FGFR2p.Trp290CysVAR_004124
5FGFR2p.Asp321AlaVAR_004129
6FGFR2p.Thr341ProVAR_004135
7FGFR2p.Cys342ArgVAR_004137
8FGFR2p.Cys342SerVAR_004138
9FGFR2p.Cys342TyrVAR_004139
10FGFR2p.Ala344ProVAR_004141
11FGFR2p.Ser351CysVAR_004143
12FGFR2p.Val359PheVAR_004146
13FGFR2p.Ala172PheVAR_017259
14FGFR2p.Tyr340CysVAR_017269
15FGFR2p.Cys342GlyVAR_017270
16FGFR2p.Tyr375CysVAR_017275
17FGFR2p.Glu565GlyVAR_017277
18FGFR2p.Lys641ArgVAR_017278
19FGFR2p.Gly663GluVAR_017280

Expression for genes affiliated with Infectious Mononucleosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Infectious Mononucleosis

Search GEO for disease gene expression data for Infectious Mononucleosis.

Pathways for genes affiliated with Infectious Mononucleosis

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 54Reactome, 60Tocris Bioscience, 50PharmGKB, 53R&D Systems, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1FGFR1, FGFR2
2
Hide members
9.1FGFR1, FGFR2
3
Hide members
9.1FGFR1, FGFR2
4
Hide members
9.1FGFR1, FGFR2
5
Hide members
9.1FGFR1, FGFR2
6
Hide members
9.1FGFR2, FGFR1
7
Hide members
9.1FGFR1, FGFR2
8
Hide members
9.1FGFR2, FGFR1
9
Hide members
9.1FGFR1, FGFR2
10
Hide members
9.1FGFR1, FGFR2
119.1FGFR1, FGFR2
129.1FGFR2, FGFR1
13
Hide members
9.1FGFR2, FGFR1
14
Hide members
9.1FGFR1, FGFR2
15
Hide members
9.1FGFR2, FGFR1
16
Hide members
9.1FGFR1, FGFR2
179.1FGFR1, FGFR2
189.1FGFR2, FGFR1
19
Hide members
9.1FGFR1, FGFR2
209.1FGFR1, FGFR2
219.1FGFR2, FGFR1
229.1FGFR2, FGFR1
23
Development FGF-family signaling
Hide members
9.1FGFR2, FGFR1
24
Hide members
9.1FGFR1, FGFR2
259.1FGFR2, FGFR1
26
Hide members
9.1FGFR2, FGFR1
279.1FGFR2, FGFR1
28
Hide members
9.1FGFR2, FGFR1

Compounds for genes affiliated with Infectious Mononucleosis

Sources:
11DrugBank, 60Tocris Bioscience, 45Novoseek, 24HMDB, 29IUPHAR, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1SU4984119.5FGFR1, FGFR2
2pd 161570609.5FGFR2, FGFR1
3fiin 1 hydrochloride609.5FGFR2, FGFR1
4su 5402609.5FGFR2, FGFR1
5su5402459.5FGFR1, FGFR2
6pd 17307445 6010.5FGFR2, FGFR1
7palifermin45 1110.4FGFR1, FGFR2
8Ponatinib 119.4FGFR1, FGFR2
9Regorafenib119.4FGFR2, FGFR1
10chondroitin sulfate45 2410.4FGFR1, FGFR2
11suramin45 29 1111.4FGFR1, FGFR2
12bromodeoxyuridine459.4FGFR2, FGFR1
13heparan sulfate45 2410.4FGFR1, FGFR2
14glyceraldehyde 3-phosphate459.4FGFR1, FGFR2
15phenylalanine459.3FGFR2, FGFR1
16agar459.3FGFR2, FGFR1
17phosphotyrosine459.3FGFR2, FGFR1
18ribonucleic acid459.2FGFR2, FGFR1
1912-o-tetradecanoylphorbol 13-acetate459.2FGFR1, FGFR2
20polysaccharide459.1FGFR1, FGFR2
21genistein45 29 60 2 11 2414.1FGFR1, FGFR2
22paclitaxel45 50 1111.0FGFR2, FGFR1
23pd 98,059458.8FGFR1, FGFR2

GO Terms for genes affiliated with Infectious Mononucleosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.1FGFR1, FGFR2

Biological processes related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:0356079.5FGFR1, FGFR2
2ventricular zone neuroblast divisionGO:0218479.5FGFR1, FGFR2
3positive regulation of phospholipase activityGO:0105189.5FGFR1, FGFR2
4mesenchymal cell differentiationGO:0487629.5FGFR2, FGFR1
5lung-associated mesenchyme developmentGO:0604849.5FGFR1, FGFR2
6branching involved in salivary gland morphogenesisGO:0604459.5FGFR1, FGFR2
7positive regulation of cardiac muscle cell proliferationGO:0600459.5FGFR2, FGFR1
8positive regulation of cell cycleGO:0457879.5FGFR1, FGFR2
9skeletal system morphogenesisGO:0487059.4FGFR1, FGFR2
10midbrain developmentGO:0309019.4FGFR2, FGFR1
11positive regulation of mesenchymal cell proliferationGO:0020539.4FGFR1, FGFR2
12ureteric bud developmentGO:0016579.4FGFR1, FGFR2
13peptidyl-tyrosine phosphorylationGO:0181089.4FGFR2, FGFR1
14inner ear morphogenesisGO:0424729.4FGFR1, FGFR2
15positive regulation of MAPK cascadeGO:0434109.4FGFR1, FGFR2
16phosphatidylinositol-mediated signalingGO:0480159.4FGFR2, FGFR1
17insulin receptor signaling pathwayGO:0082869.3FGFR1, FGFR2
18protein autophosphorylationGO:0467779.3FGFR1, FGFR2
19fibroblast growth factor receptor signaling pathwayGO:0085439.3FGFR2, FGFR1
20Fc-epsilon receptor signaling pathwayGO:0380959.2FGFR1, FGFR2
21epidermal growth factor receptor signaling pathwayGO:0071739.2FGFR1, FGFR2
22angiogenesisGO:0015259.1FGFR2, FGFR1
23positive regulation of cell proliferationGO:0082849.1FGFR1, FGFR2
24in utero embryonic developmentGO:0017019.0FGFR1, FGFR2
25neurotrophin TRK receptor signaling pathwayGO:0480118.8FGFR1, FGFR2

Molecular functions related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.1FGFR1, FGFR2
2heparin bindingGO:0082019.1FGFR1, FGFR2
3fibroblast growth factor bindingGO:0171349.0FGFR1, FGFR2
4protein tyrosine kinase activityGO:0047138.8FGFR1, FGFR2

Products for genes affiliated with Infectious Mononucleosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Infectious Mononucleosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet