ACS5
MCID: INF030
MIFTS: 78

Infectious Mononucleosis (ACS5) malady

Infectious diseases, Eye diseases, Bone diseases, Fetal diseases, Endocrine diseases categories

Summaries for Infectious Mononucleosis

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Pfeiffer syndrome is a disorder that affects the bones in the skull, hands and feet. signs and symptoms can include craniosynostosis, which prevents normal skull growth and affects the shape of the head and face; distinctive facial features including bulging and wide-set eyes, a high forehead, an underdeveloped upper jaw, and a beaked nose; hearing loss; and dental problems. other features may include broad and deviated thumbs and great toes; brachydactyly; and syndactyly. it is caused by mutations in the fgfr1 or fgfr2 genes and is inherited in an autosomal dominant manner. the syndrome is divided into 3 subtypes (types 1, 2 and 3) based on the presence and severity of signs and symptoms. management typically includes various surgical interventions. last updated: 5/2/2011

MalaCards: Infectious Mononucleosis, also known as pfeiffer syndrome, is related to craniosynostosis and crouzon syndrome, and has symptoms including fever, lymphadenopathy and fatigue. An important gene associated with Infectious Mononucleosis is FGFR1 (fibroblast growth factor receptor 1), and among its related pathways are NF-KappaB Family Pathway and Regulation of Actin Cytoskeleton. The compounds SU4984 and pd 161570 have been mentioned in the context of this disorder. Affiliated tissues include pharynx, bone and spleen.

Disease Ontology:8 A viral infectious disease that results in inflammation, located in pharynx, has material basis in human herpesvirus 4 and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly.

Genetics Home Reference:21 Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face. Pfeiffer syndrome also affects bones in the hands and feet.

MedlinePlus:33 Infectious mononucleosis, or "mono", is an infection usually caused by the epstein-barr virus. the virus spreads through saliva, which is why it's sometimes called "kissing disease." mono occurs most often in teens and young adults. however, you can get it at any age. symptoms of mono include fever sore throat swollen lymph glands sometimes you may also have a swollen spleen. serious problems are rare. a blood test can show if you have mono. most people get better in two to four weeks. however, you may feel tired for a few months afterward. treatment focuses on helping symptoms and includes medicines for pain and fever, warm salt water gargles and plenty of rest and fluids.

Wikipedia:63 Infectious mononucleosis (IM; also known as mono, glandular fever, Pfeiffer\'s disease, Filatov\'s... more...

Description from OMIM:46 101600

Aliases & Classifications for Infectious Mononucleosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 9diseasecard, 63Wikipedia, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 48Orphanet, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
pfeiffer syndrome:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

infectious mononucleosis 8 10 44 33 60
pfeiffer syndrome 8 9 63 42 22 21 46 44 48
craniofacial-skeletal-dermatologic dysplasia 21 46 60
acs5 42 21 48
pfeiffer type acrocephalosyndactyly 42 60
acrocephalosyndactyly, type v 63 21
noack syndrome 63 21
acrocephalopolysyndactyly type iv 60
gammaherpesviral mononucleosis 8
acrocephalosyndactylia type v 8
acrocephalosyndactyly, type 5 42
acrocephalosyndactyly type 5 48
pfeiffer's disease 8
filatov's disease 8
monocytic angina 8
glandular fever 8
mononucleosis 8
acs v 21


External Ids:

Disease Ontology8 DOID:8568, DOID:14705
NCIt39 C34726
ICD9CM27 075
OMIM46 101600
MESH via Orphanet35 C538582
ICD10 via Orphanet26 Q87.0
SNOMED-CT via Orphanet57 70410008
UMLS via Orphanet61 C2931888
ICD1025 B27, B27.0

Related Diseases for Infectious Mononucleosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Infectious Mononucleosis:



Diseases related to infectious mononucleosis

Clinical Features for Infectious Mononucleosis

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Sources:
46OMIM, 8Disease Ontology
See all sources

Clinical features from OMIM:

101600

Clinical synopsis from OMIM:

101600

Symptoms:

8 (show all 27)
  • fever
  • lymphadenopathy
  • fatigue
  • clinodactyly of fifth finger
  • autosomal dominant inheritance
  • turricephaly/oxycephaly/acrocephaly
  • symphalangy of fingers
  • hip dislocation/dysplasia/coxa valga/coxa vara/coxa plana
  • splenomegaly
  • lordosis
  • high vaulted/narrow palate
  • ptosis
  • syndactyly of fingers/interdigital palm
  • short neck
  • flat cheek bones/malar hypoplasia
  • prognathism/prognathia
  • broad/bifid thumb
  • short stature/dwarfism/nanism
  • carpal bones fusion/synostosis
  • high forehead
  • mouth held open
  • facial structural asymmetry/facial hemiatrophy/facial hemihypertrophy
  • short philtrum
  • flat face
  • broad nasal root
  • short hand/brachydactyly
  • hypertelorism

Drugs & Therapeutics for Infectious Mononucleosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Infectious Mononucleosis

Drug clinical trials:

Search ClinicalTrials for Infectious Mononucleosis

Search NIH Clinical Center for Infectious Mononucleosis

Search CenterWatch for Infectious Mononucleosis

Genetic Tests for Infectious Mononucleosis

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Sources:
22GTR
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Genetic tests related to Infectious Mononucleosis:

id Genetic test Affiliating Genes
1 Pfeiffer Syndrome22

Anatomical Context for Infectious Mononucleosis

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Infectious Mononucleosis:

32
Bone, Spleen, Testes, T cells, Eye, Monocytes, B cells, Tonsil, Liver, Lymph node, Lung, Tongue, Skin, Breast, Thyroid, Colon

FMA organs/tissues related to Infectious Mononucleosis:

14
Pharynx

Animal Models for Infectious Mononucleosis or affiliated genes

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Publications for Infectious Mononucleosis

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Sources:
50PubMed
See all sources

Articles related to Infectious Mononucleosis:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
A diagnostic blind spot: acute infectious mononucleosis or acute retroviral syndrome. (23968909)
2013
2
Mycoplasma pneumoniae preceding Lemierre's syndrome due to Fusobacterium nucleatum complicated by acute Epstein-Barr virus (EBV) infectious mononucleosis in an immunocompetent host. (22464641)
2013
3
Spontaneous splenic rupture in infectious mononucleosis. (24224308)
2013
4
Infectious mononucleosis mimicking malignant T-cell lymphoma in the nasopharynx: a case report and review of the literature. (23236550)
2013
5
Antibody titers against EBNA1 and EBNA2 in relation to Hodgkin lymphoma and history of infectious mononucleosis. (21805472)
2012
6
Babesiosis mimicking Epstein Barr Virus (EBV) infectious mononucleosis: another cause of false positive monospot tests. (22266386)
2012
7
Infectious mononucleosis or glandular fever revisited. (24432277)
2012
8
Characterization of Epstein-Barr virus (EBV) BZLF1 gene promoter variants and comparison of cellular gene expression profiles in Japanese patients with infectious mononucleosis, chronic active EBV infection, and EBV-associated hemophagocytic lymphohistiocytosis. (22511310)
2012
9
Genetic polymorphism of GST gene in children with infectious mononucleosis and acute lymphocytic leukemia]. (22537952)
2012
10
Alice in Wonderland syndrome and upper airway obstruction in infectious mononucleosis. (21563558)
2011
11
Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis. (20858235)
2010
12
Case of the month. Streptococcal pharyngitis and infectious mononucleosis. (18795552)
2008
13
Selective association of multiple sclerosis with infectious mononucleosis. (18208871)
2008
14
Onset of alopecia areata after Epstein-Barr virus infectious mononucleosis. (18329131)
2008
15
Epstein-Barr virus-positive blastoid variant of mantle cell lymphoma in an adult with recurrent infectious mononucleosis-like symptoms: a case report. (17483058)
2007
16
Nonoperative management of spontaneous splenic rupture in infectious mononucleosis: a case report and review of the literature. (17671047)
2007
17
Morphological and molecular diagnosis of a fatal form of EBV infectious mononucleosis in a child. (17019975)
2006
18
1. Fatal acute hepatitis in infectious mononucleosis in a forensic setting: a case report. (16117288)
2005
19
Nonoperative management of blunt splenic injury in infectious mononucleosis. (15986965)
2005
20
Trend of the CD23+ B cells in children with infectious mononucleosis caused by Epstein-Barr virus]. (15796797)
2005
21
Dexamethasone for the treatment of sore throat in children with suspected infectious mononucleosis: a randomized, double-blind, placebo-controlled, clinical trial. (14993084)
2004
22
Infectious mononucleosis hepatitis: a case-report. (15257252)
2004
23
Infectious mononucleosis (IM) associated rupture of the spleen. (14964512)
2004
24
Infectious mononucleosis and Epstein-Barr virus. (15541197)
2004
25
Association between late age at infectious mononucleosis, Epstein-Barr virus antibodies, and ovarian cancer risk. (14606612)
2003
26
Paul-Bunnell antigen and a possible mechanism of formation of heterophile antibodies in patients with infectious mononucleosis. (14740007)
2003
27
Fatal infectious mononucleosis with evidence suggestive of the development of B cell lymphoma. (14507324)
2003
28
Is agranulocytosis following infectious mononucleosis caused by autoimmunity? (14578031)
2003
29
Severe gastritis secondary to Epstein-Barr viral infection. Unusual presentation of infectious mononucleosis and associated diffuse lymphoid hyperplasia in gastric mucosa. (12683879)
2003
30
Lemmiere's syndrome following infectious mononucleosis. (14614981)
2003
31
Active infective endocarditis due to methicillin-resistant Staphylococcus aureus in the acute phase of infectious mononucleosis. (12073602)
2002
32
Neuralgic amyotrophy as a manifestation of infectious mononucleosis. (12532929)
2002
33
Transfusion-related infectious mononucleosis. (12477336)
2002
34
Non hypoxia-related splenic infarct in a patient with sickle cell trait and infectious mononucleosis. (11340255)
2001
35
Severe hypoglycaemia in a patient with glycogen storage disease type III induced by infectious mononucleosis. (11916322)
2001
36
Acute complications of Epstein-Barr virus infectious mononucleosis. (10836164)
2000
37
Evaluation of a novel dry latex preparation for demonstration of infectious mononucleosis heterophile antibody in comparison with three established tests. (9854070)
1999
38
Spontaneous splenic rupture in infectious mononucleosis: conservative management with gradual percutaneous drainage of a subcapsular hematoma. (10079351)
1999
39
Syngeneic blood stem cell transplantation for infectious mononucleosis-related aplastic anaemia. (10444179)
1999
40
Massive splenomegaly and Epstein-Barr virus-associated infectious mononucleosis in a patient with Gaucher disease. (10029812)
1999
41
Immune complex disease associated with Epstein-Barr virus infectious mononucleosis. (9811388)
1998
42
Spleen rupture in infectious mononucleosis: report of one case. (9684527)
1998
43
Clinical pathology case conference. Infectious mononucleosis. (9569871)
1996
44
Infectious mononucleosis with pulmonary consolidation. (8820027)
1996
45
Decreased levels of circulating IFN-alpha and increased sCD23 in patients with acute infectious mononucleosis. (8733919)
1996
46
Evaluations of enzyme-linked immunosorbent assay procedure for determining specific Epstein-Barr virus serology and of rapid test kits for diagnosis for infectious mononucleosis. (8940484)
1996
47
Drug eruption induced by acetaminophen in infectious mononucleosis. (7751106)
1995
48
Absence of bcl-2 expression by activated CD45RO+ T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death. (8329707)
1993
49
Letter: Brachial plexus neuropathy associated with infectious mononucleosis. (1268786)
1976
50
Diabetes mellitus, fibrocongestive splenomegaly (Banti's syndrome) and infectious mononucleosis. (20294357)
1947

Genetic Variations for Infectious Mononucleosis

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Infectious Mononucleosis:

62 (show all 38)
id Symbol AA change Variation ID SNP ID
1FGFR1p.Pro252ArgVAR_004111
2FGFR1p.Pro252ArgVAR_004111
3FGFR2p.Ser252TrpVAR_004115
4FGFR2p.Ser252TrpVAR_004115
5FGFR2p.Cys278PheVAR_004121
6FGFR2p.Cys278PheVAR_004121
7FGFR2p.Trp290CysVAR_004124
8FGFR2p.Trp290CysVAR_004124
9FGFR2p.Asp321AlaVAR_004129
10FGFR2p.Asp321AlaVAR_004129
11FGFR2p.Thr341ProVAR_004135
12FGFR2p.Thr341ProVAR_004135
13FGFR2p.Cys342ArgVAR_004137
14FGFR2p.Cys342ArgVAR_004137
15FGFR2p.Cys342SerVAR_004138
16FGFR2p.Cys342SerVAR_004138
17FGFR2p.Cys342TyrVAR_004139
18FGFR2p.Cys342TyrVAR_004139
19FGFR2p.Ala344ProVAR_004141
20FGFR2p.Ala344ProVAR_004141
21FGFR2p.Ser351CysVAR_004143
22FGFR2p.Ser351CysVAR_004143
23FGFR2p.Val359PheVAR_004146
24FGFR2p.Val359PheVAR_004146
25FGFR2p.Ala172PheVAR_017259
26FGFR2p.Ala172PheVAR_017259
27FGFR2p.Tyr340CysVAR_017269
28FGFR2p.Tyr340CysVAR_017269
29FGFR2p.Cys342GlyVAR_017270
30FGFR2p.Cys342GlyVAR_017270
31FGFR2p.Tyr375CysVAR_017275
32FGFR2p.Tyr375CysVAR_017275
33FGFR2p.Glu565GlyVAR_017277
34FGFR2p.Glu565GlyVAR_017277
35FGFR2p.Lys641ArgVAR_017278
36FGFR2p.Lys641ArgVAR_017278
37FGFR2p.Gly663GluVAR_017280
38FGFR2p.Gly663GluVAR_017280

Expression for genes affiliated with Infectious Mononucleosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Infectious Mononucleosis

Search GEO for disease gene expression data for Infectious Mononucleosis.

Pathways for genes affiliated with Infectious Mononucleosis

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 53Reactome, 59Tocris Bioscience, 49PharmGKB, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1FGFR1, FGFR2
2
Hide members
9.1FGFR1, FGFR2
3
Hide members
9.1FGFR2, FGFR1
4
Hide members
9.1FGFR1, FGFR2
5
Hide members
9.1FGFR1, FGFR2
6
Hide members
9.1FGFR1, FGFR2
7
Hide members
9.1FGFR2, FGFR1
8
Hide members
9.1FGFR1, FGFR2
9
Hide members
9.1FGFR1, FGFR2
10
Hide members
9.1FGFR1, FGFR2
119.1FGFR1, FGFR2
129.1FGFR2, FGFR1
13
Hide members
9.1FGFR1, FGFR2
14
Hide members
9.1FGFR2, FGFR1
15
Hide members
9.1FGFR1, FGFR2
16
Hide members
9.1FGFR1, FGFR2
179.1FGFR1, FGFR2
189.1FGFR2, FGFR1
19
Hide members
9.1FGFR1, FGFR2
20
Hide members
9.1FGFR1, FGFR2
219.1FGFR1, FGFR2
229.1FGFR2, FGFR1
23
Development FGF-family signaling
Hide members
9.1FGFR2, FGFR1
24
Hide members
9.1FGFR1, FGFR2
259.1FGFR1, FGFR2
26
Hide members
9.1FGFR1, FGFR2
279.1FGFR1, FGFR2
289.1FGFR1, FGFR2

Compounds for genes affiliated with Infectious Mononucleosis

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Sources:
11DrugBank, 59Tocris Bioscience, 44Novoseek, 24HMDB, 28IUPHAR, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1SU4984119.5FGFR1, FGFR2
2pd 161570599.5FGFR2, FGFR1
3fiin 1 hydrochloride599.5FGFR2, FGFR1
4su 5402599.5FGFR2, FGFR1
5su5402449.5FGFR1, FGFR2
6pd 17307444 5910.5FGFR2, FGFR1
7palifermin44 1110.4FGFR1, FGFR2
8Ponatinib 119.4FGFR1, FGFR2
9Regorafenib119.4FGFR2, FGFR1
10chondroitin sulfate44 2410.4FGFR1, FGFR2
11suramin44 28 1111.4FGFR1, FGFR2
12bromodeoxyuridine449.4FGFR2, FGFR1
13heparan sulfate44 2410.4FGFR1, FGFR2
14glyceraldehyde 3-phosphate449.4FGFR1, FGFR2
15phenylalanine449.3FGFR2, FGFR1
16agar449.3FGFR2, FGFR1
17phosphotyrosine449.3FGFR2, FGFR1
18ribonucleic acid449.2FGFR2, FGFR1
1912-o-tetradecanoylphorbol 13-acetate449.2FGFR1, FGFR2
20polysaccharide449.1FGFR1, FGFR2
21genistein44 28 59 2 11 2414.1FGFR1, FGFR2
22paclitaxel44 49 1111.0FGFR2, FGFR1
23pd 98,059448.8FGFR1, FGFR2

GO Terms for genes affiliated with Infectious Mononucleosis

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16Gene Ontology
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Cellular components related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.1FGFR1, FGFR2

Biological processes related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:0356079.5FGFR1, FGFR2
2ventricular zone neuroblast divisionGO:0218479.5FGFR1, FGFR2
3positive regulation of phospholipase activityGO:0105189.5FGFR1, FGFR2
4mesenchymal cell differentiationGO:0487629.5FGFR2, FGFR1
5lung-associated mesenchyme developmentGO:0604849.5FGFR1, FGFR2
6branching involved in salivary gland morphogenesisGO:0604459.5FGFR1, FGFR2
7positive regulation of cardiac muscle cell proliferationGO:0600459.5FGFR2, FGFR1
8positive regulation of cell cycleGO:0457879.5FGFR1, FGFR2
9skeletal system morphogenesisGO:0487059.4FGFR1, FGFR2
10midbrain developmentGO:0309019.4FGFR2, FGFR1
11positive regulation of mesenchymal cell proliferationGO:0020539.4FGFR1, FGFR2
12ureteric bud developmentGO:0016579.4FGFR1, FGFR2
13peptidyl-tyrosine phosphorylationGO:0181089.4FGFR2, FGFR1
14inner ear morphogenesisGO:0424729.4FGFR1, FGFR2
15positive regulation of MAPK cascadeGO:0434109.4FGFR1, FGFR2
16phosphatidylinositol-mediated signalingGO:0480159.4FGFR2, FGFR1
17insulin receptor signaling pathwayGO:0082869.3FGFR1, FGFR2
18protein autophosphorylationGO:0467779.3FGFR1, FGFR2
19fibroblast growth factor receptor signaling pathwayGO:0085439.3FGFR2, FGFR1
20Fc-epsilon receptor signaling pathwayGO:0380959.2FGFR1, FGFR2
21epidermal growth factor receptor signaling pathwayGO:0071739.2FGFR1, FGFR2
22angiogenesisGO:0015259.1FGFR2, FGFR1
23positive regulation of cell proliferationGO:0082849.1FGFR1, FGFR2
24in utero embryonic developmentGO:0017019.0FGFR1, FGFR2
25neurotrophin TRK receptor signaling pathwayGO:0480118.8FGFR1, FGFR2

Molecular functions related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.1FGFR1, FGFR2
2heparin bindingGO:0082019.1FGFR1, FGFR2
3fibroblast growth factor bindingGO:0171349.0FGFR1, FGFR2
4protein tyrosine kinase activityGO:0047138.8FGFR1, FGFR2

Products for genes affiliated with Infectious Mononucleosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Infectious Mononucleosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet