ACS5
MCID: INF030
MIFTS: 84

Infectious Mononucleosis (ACS5) malady

Genetic diseases, Rare diseases, Infectious diseases, Eye diseases, Bone diseases, Fetal diseases, Skin diseases, Endocrine diseases, Oral diseases categories
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Summaries for Infectious Mononucleosis

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NIH Rare Diseases:42 Pfeiffer syndrome is a disorder that affects the bones in the skull, hands and feet. signs and symptoms can include craniosynostosis, which prevents normal skull growth and affects the shape of the head and face; distinctive facial features including bulging and wide-set eyes, a high forehead, an underdeveloped upper jaw, and a beaked nose; hearing loss; and dental problems. other features may include broad and deviated thumbs and great toes; brachydactyly; and syndactyly. it is caused by mutations in the fgfr1 or fgfr2 genes and is inherited in an autosomal dominant manner. the syndrome is divided into 3 subtypes (types 1, 2 and 3) based on the presence and severity of signs and symptoms. management typically includes various surgical interventions. last updated: 7/25/2014

MalaCards based summary: Infectious Mononucleosis, also known as pfeiffer syndrome, is related to agammaglobulinemia and lupus erythematosus, and has symptoms including flat cheek bones/malar hypoplasia, ptosis and broad/bifid thumb. An important gene associated with Infectious Mononucleosis is FGFR1 (fibroblast growth factor receptor 1), and among its related pathways are Alzheimers Disease Pathway and Signaling by FGFR1 mutants. The compounds pd 161570 and fiin 1 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include pharynx, bone and spleen, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

Disease Ontology:8 A viral infectious disease that results in inflammation, located in pharynx, has material basis in human herpesvirus 4 and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly.

Genetics Home Reference:21 Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face. Pfeiffer syndrome also affects bones in the hands and feet.

MedlinePlus:33 Infectious mononucleosis, or "mono", is an infection usually caused by the epstein-barr virus. the virus spreads through saliva, which is why it's sometimes called "kissing disease." mono occurs most often in teens and young adults. however, you can get it at any age. symptoms of mono include fever sore throat swollen lymph glands sometimes you may also have a swollen spleen. serious problems are rare. a blood test can show if you have mono. most people get better in two to four weeks. however, you may feel tired for a few months afterward. treatment focuses on helping symptoms and includes medicines for pain and fever, warm salt water gargles and plenty of rest and fluids.

Wikipedia:65 Infectious mononucleosis (IM; also known as mono, glandular fever, Pfeiffer\'s disease, Filatov\'s... more...

Description from OMIM:46 101600

Aliases & Classifications for Infectious Mononucleosis

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Sources:
8Disease Ontology, 9diseasecard, 65Wikipedia, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Infectious Mononucleosis, Aliases & Descriptions:

Name: Infectious Mononucleosis 8 10 44 33 62
Pfeiffer Syndrome 9 65 42 21 46 44 48 62
Acs5 42 21 48 62
Craniofacial-Skeletal-Dermatologic Dysplasia 21 46 62
Noack Syndrome 65 21 62
Pfeiffer Type Acrocephalosyndactyly 42 62
Gammaherpesviral Mononucleosis 8 62
Acrocephalosyndactyly, Type V 65 21
 
Pfeiffer's Disease 8 22
Acrocephalosyndactyly, Type 5 42
Acrocephalosyndactyly Type 5 48
Filatov's Disease 8
Monocytic Angina 8
Glandular Fever 8
Mononucleosis 8
Acs V 21


Classifications:



Characteristics (Orphanet epidemiological data):

48
pfeiffer syndrome:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


External Ids:

Disease Ontology8 DOID:8568
ICD9CM27 075
NCIt39 C34726
MeSH34 D007244
OMIM46 101600
MESH via Orphanet35 C538582
ICD10 via Orphanet26 Q87.0
UMLS via Orphanet63 C2931888
ICD1025 B27, B27.0

Related Diseases for Infectious Mononucleosis

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Diseases related to Infectious Mononucleosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1agammaglobulinemia30.9SH2D1A, CD79A, CD40LG
2lupus erythematosus30.9CD40LG, CD79A
3q fever30.8CD79A
4hodgkin's lymphoma30.7RAG2, IL2RB, SH2D1A
5hepatitis30.7GUSB, TPI1, IL2RB, CD4, CD40LG
6measles30.7CD4, CD79A, CD40LG
7pneumonia30.7IL2RB, CD4, CD79A
8achondroplasia30.7FGFR2
9autoimmune hemolytic anemia30.6CD79A, CD40LG
10craniosynostosis30.6FGFR2, FGFR1
11syphilis30.5CD79A, CD4
12meningoencephalitis30.5CD4, CD79A
13thrombocytopenia30.5CD40LG, CD79A, CD4, GUSB
14aspergillosis30.4CD4, CD79A
15peripheral t-cell lymphoma30.4IL2RB, CD4
16crouzon syndrome30.4FGFR2, FGFR1
17thyroiditis30.4CD4, CD79A
18saethre-chotzen syndrome30.4FGFR2, FGFR1
19cryoglobulinemia30.3CD40LG, CD79A
20leukopenia30.2GUSB, CD4, CD79A
21influenza30.2IL2RB, CD4, CD79A
22arthritis30.2CD4, RAG2, IL2RB, GUSB
23rheumatoid arthritis30.0GUSB, IL2RB, CD4, CD79A, CD40LG
24diphtheria30.0IL2RB, CD4, CD79A, FGFR2
25non-hodgkin lymphoma30.0SH2D1A, IL2RB, CR2, FGFR1
26t-cell leukemia29.9CD4, RAG2, CR2, IL2RB
27eosinophilia29.8IL2RB, CD4, CD79A, FGFR1
28systemic lupus erythematosus29.6GUSB, TPI1, IL2RB, CR2, CD4, CD79A
29leukemia28.7GUSB, SH2D1A, IL2RB, CR2, RAG2, CD4
30pfeiffer syndrome11.1
31multiple sclerosis10.7
32tonsillitis10.6
33macroglobulinemia10.5CD79A
34histoplasmosis10.5CD4
35epidermolysis bullosa acquisita10.5CD79A
36winkelman bethge pfeiffer syndrome10.4
37splenic infarction10.4
38chronic fatigue syndrome10.4
39antley-bixler syndrome10.4FGFR2
40cd40 ligand deficiency10.4SH2D1A, CD40LG
41pfeiffer syndrome type 110.4
42cryptococcosis10.4CD4
43hemolytic anemia10.4
44nasopharyngitis10.4
45myocarditis10.4
46virus associated hemophagocytic syndrome10.4
47blindness10.4
48dysgammaglobulinemia10.4SH2D1A, CD79A
49congenital toxoplasmosis10.4CD40LG, CD79A
50immunoglobulin g deficiency10.4CD40LG, CD79A

Graphical network of the top 20 diseases related to Infectious Mononucleosis:



Diseases related to infectious mononucleosis

Symptoms for Infectious Mononucleosis

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Symptoms by clinical synopsis from OMIM:

101600

Clinical features from OMIM:

101600

Symptoms:

48 (show all 23)
  • flat cheek bones/malar hypoplasia
  • ptosis
  • broad/bifid thumb
  • autosomal dominant inheritance
  • turricephaly/oxycephaly/acrocephaly
  • high forehead
  • hypertelorism
  • broad nasal root
  • short hand/brachydactyly
  • syndactyly of fingers/interdigital palm
  • symphalangy of fingers
  • clinodactyly of fifth finger
  • flat face
  • facial structural asymmetry/facial hemiatrophy/facial hemihypertrophy
  • prognathism/prognathia
  • mouth held open
  • short philtrum
  • high vaulted/narrow palate
  • short neck
  • lordosis
  • carpal bones fusion/synostosis
  • hip dislocation/dysplasia/coxa valga/coxa vara/coxa plana
  • short stature/dwarfism/nanism

HPO human phenotypes related to Infectious Mononucleosis:

(show all 51)
id Description Frequency HPO Source Accession
1 ptosis hallmark (90%) HP:0000508
2 abnormality of thumb phalanx hallmark (90%) HP:0009602
3 cheekbone underdevelopment hallmark (90%) HP:0010669
4 hypertelorism typical (50%) HP:0000316
5 high forehead typical (50%) HP:0000348
6 wide nasal bridge typical (50%) HP:0000431
7 brachydactyly syndrome typical (50%) HP:0001156
8 abnormality of calvarial morphology typical (50%) HP:0002648
9 clinodactyly of the 5th finger typical (50%) HP:0004209
10 finger syndactyly typical (50%) HP:0006101
11 symphalangism affecting the phalanges of the hand typical (50%) HP:0009773
12 abnormality of the palate occasional (7.5%) HP:0000174
13 open mouth occasional (7.5%) HP:0000194
14 malar flattening occasional (7.5%) HP:0000272
15 mandibular prognathia occasional (7.5%) HP:0000303
16 short philtrum occasional (7.5%) HP:0000322
17 facial asymmetry occasional (7.5%) HP:0000324
18 short neck occasional (7.5%) HP:0000470
19 abnormality of the hip bone occasional (7.5%) HP:0003272
20 hyperlordosis occasional (7.5%) HP:0003307
21 short stature occasional (7.5%) HP:0004322
22 synostosis of carpal bones occasional (7.5%) HP:0005048
23 autosomal dominant inheritance HP:0000006
24 high palate HP:0000218
25 hydrocephalus HP:0000238
26 brachyturricephaly HP:0000244
27 mandibular prognathia HP:0000303
28 hypertelorism HP:0000316
29 hypoplasia of the maxilla HP:0000327
30 choanal stenosis HP:0000452
31 choanal atresia HP:0000453
32 strabismus HP:0000486
33 downslanted palpebral fissures HP:0000494
34 shallow orbits HP:0000586
35 dental crowding HP:0000678
36 syndactyly HP:0001159
37 intellectual disability HP:0001249
38 arnold-chiari malformation HP:0002308
39 cloverleaf skull HP:0002676
40 bronchomalacia HP:0002780
41 humeroradial synostosis HP:0003041
42 elbow ankylosis HP:0003070
43 short nose HP:0003196
44 short middle phalanx of toe HP:0003795
45 coronal craniosynostosis HP:0004440
46 depressed nasal bridge HP:0005280
47 cartilaginous trachea HP:0005347
48 finger syndactyly HP:0006101
49 shortening of all middle phalanges of the fingers HP:0006110
50 broad hallux HP:0010055
51 broad thumb HP:0011304

Drugs & Therapeutics for Infectious Mononucleosis

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Drug clinical trials:

Search ClinicalTrials for Infectious Mononucleosis

Search NIH Clinical Center for Infectious Mononucleosis

Genetic Tests for Infectious Mononucleosis

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Genetic tests related to Infectious Mononucleosis:

id Genetic test Affiliating Genes
1 Pfeiffer Syndrome22

Anatomical Context for Infectious Mononucleosis

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MalaCards organs/tissues related to Infectious Mononucleosis:

32
Bone, Spleen, Testes, T cells, Eye, Monocytes, B cells, Tonsil, Liver, Lymph node, Lung, Colon, Thyroid, Breast, Skin, Tongue

FMA organs/tissues related to Infectious Mononucleosis:

14
Pharynx

Animal Models for Infectious Mononucleosis or affiliated genes

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Publications for Infectious Mononucleosis

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Articles related to Infectious Mononucleosis:

(show top 50)    (show all 587)
idTitleAuthorsYear
1
In reference to Use of the lymphocyte count as a diagnostic screen in adults with suspected Epstein-Barr virus infectious mononucleosis. (24610140)
2014
2
A genetic basis for infectious mononucleosis: evidence from a family study of hospitalized cases in Denmark. (24696238)
2014
3
Editorial commentary: Genetics and infectious mononucleosis. (24696239)
2014
4
Splenic rupture: a rare complication of infectious mononucleosis. (25332037)
2014
5
Infectious mononucleosis hepatitis; an unwelcome present for Father Christmas. (23732134)
2013
6
Idiopathic pure sudomotor failure and cholinergic urticaria in a patient after acute infectious mononucleosis infection. (22924754)
2013
7
Spontaneous splenic rupture resulted from infectious mononucleosis. (22288057)
2012
8
B-cell polyclonal activation and Epstein-Barr viral abortive lytic cycle are two key features in acute infectious mononucleosis. (21684200)
2011
9
Lymph node lesion of acute infectious mononucleosis in the elderly : a case report. (22104316)
2011
10
Alice in Wonderland syndrome and upper airway obstruction in infectious mononucleosis. (21563558)
2011
11
Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis. (20051521)
2010
12
Peripheral blood alterations in a patient with infectious mononucleosis. (20507303)
2010
13
Case of the month. Streptococcal pharyngitis and infectious mononucleosis. (18795552)
2008
14
Methylprednisolone pulse therapy for severe immune thrombocytopenia associated with infectious mononucleosis. (17160996)
2007
15
Causes of infectious mononucleosis-like syndrome in adult patients. (16880711)
2006
16
The coexistence of hepatitis A and infectious mononucleosis. (16252202)
2005
17
Cefprozil-induced rash in infectious mononucleosis. (15827073)
2005
18
Role of screening for infectious mononucleosis in patients admitted with isolated, unilateral peritonsillar abscess. (15165311)
2004
19
Massive retropharyngeal lymphadenopathy in an infant: an unusual presentation of infectious mononucleosis. (15667689)
2004
20
Electron microscopic characteristics of peripheral blood lymphocytes in children with infectious mononucleosis. (15455094)
2004
21
A randomised controlled trial of a psycho-educational intervention to aid recovery in infectious mononucleosis. (15256300)
2004
22
Infectious mononucleosis progressing to fatal malignant lymphoma: a case report and review of the literature. (12916875)
2003
23
Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity. (12452866)
2002
24
Recovery from infectious mononucleosis: a case for more than symptomatic therapy? A systematic review. (12392128)
2002
25
Infectious mononucleosis in active patients: definitive answers to common questions. (20086504)
2002
26
Infectious mononucleosis, peripheral blood. Hematology morphology forum. (12243986)
2002
27
Unexpected death due to infectious mononucleosis. (12064653)
2002
28
The management of severe infectious mononucleosis tonsillitis and upper airway obstruction. (11779326)
2001
29
Spontaneous splenic rupture in infectious mononucleosis. (11554870)
2001
30
Infectious mononucleosis. A clinical review. (12420480)
2001
31
Acute complications of Epstein-Barr virus infectious mononucleosis. (10836164)
2000
32
Evaluation of two slide agglutination tests and a novel immunochromatographic assay for rapid diagnosis of infectious mononucleosis. (10973466)
2000
33
Infectious mononucleosis in middle age. (9952206)
1999
34
Infectious mononucleosis: psychological symptoms during acute and subacute phases of illness. (10068917)
1999
35
Evaluation of a novel dry latex preparation for demonstration of infectious mononucleosis heterophile antibody in comparison with three established tests. (9854070)
1999
36
Spontaneous splenic rupture in infectious mononucleosis: conservative management with gradual percutaneous drainage of a subcapsular hematoma. (10079351)
1999
37
Acyclovir for treatment of infectious mononucleosis: a meta-analysis. (10680982)
1999
38
Pseudoappendicitis preceding infectious mononucleosis. (9814402)
1998
39
Spontaneous splenic rupture and infectious mononucleosis in a forensic setting. (9825550)
1998
40
Nephrotic syndrome and concurrent infectious mononucleosis. (9090679)
1997
41
Clinical pathology case conference. Infectious mononucleosis. (9569871)
1996
42
Human and viral interleukin-10 in acute Epstein-Barr virus-induced infectious mononucleosis. (7751715)
1995
43
BLT-esterase in infectious mononucleosis. (7743659)
1995
44
Patterns of cytokine gene expression in infectious mononucleosis. (8298133)
1994
45
Infectious mononucleosis: hemolysis by autoantibodies against triosephosphate isomerase]. (2170094)
1990
46
Infectious mononucleosis presenting as bilateral acute dacryocystitis. (2275940)
1990
47
Acute periarthritis in a patient with infectious mononucleosis. (3395388)
1988
48
Profound granulocytopenia associated with infectious mononucleosis. (4706394)
1973
49
A possible relationship between acute necrotizing ulcerative gingivitis and infectious mononucleosis. (5288705)
1971
50
Acquired Pelger-HuA5183182)
1967

Variations for Infectious Mononucleosis

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UniProtKB/Swiss-Prot genetic disease variations for Infectious Mononucleosis:

64 (show all 38)
id Symbol AA change Variation ID SNP ID
1FGFR1p.Pro252ArgVAR_004111
2FGFR1p.Pro252ArgVAR_004111
3FGFR2p.Ser252TrpVAR_004115
4FGFR2p.Ser252TrpVAR_004115
5FGFR2p.Cys278PheVAR_004121
6FGFR2p.Cys278PheVAR_004121
7FGFR2p.Trp290CysVAR_004124
8FGFR2p.Trp290CysVAR_004124
9FGFR2p.Asp321AlaVAR_004129
10FGFR2p.Asp321AlaVAR_004129
11FGFR2p.Thr341ProVAR_004135
12FGFR2p.Thr341ProVAR_004135
13FGFR2p.Cys342ArgVAR_004137
14FGFR2p.Cys342ArgVAR_004137
15FGFR2p.Cys342SerVAR_004138
16FGFR2p.Cys342SerVAR_004138
17FGFR2p.Cys342TyrVAR_004139
18FGFR2p.Cys342TyrVAR_004139
19FGFR2p.Ala344ProVAR_004141
20FGFR2p.Ala344ProVAR_004141
21FGFR2p.Ser351CysVAR_004143
22FGFR2p.Ser351CysVAR_004143
23FGFR2p.Val359PheVAR_004146
24FGFR2p.Val359PheVAR_004146
25FGFR2p.Ala172PheVAR_017259
26FGFR2p.Ala172PheVAR_017259
27FGFR2p.Tyr340CysVAR_017269
28FGFR2p.Tyr340CysVAR_017269
29FGFR2p.Cys342GlyVAR_017270
30FGFR2p.Cys342GlyVAR_017270
31FGFR2p.Tyr375CysVAR_017275
32FGFR2p.Tyr375CysVAR_017275
33FGFR2p.Glu565GlyVAR_017277
34FGFR2p.Glu565GlyVAR_017277
35FGFR2p.Lys641ArgVAR_017278
36FGFR2p.Lys641ArgVAR_017278
37FGFR2p.Gly663GluVAR_017280
38FGFR2p.Gly663GluVAR_017280

Clinvar genetic disease variations for Infectious Mononucleosis:

6 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1FGFR2NM_000141.4(FGFR2): c.1025G> A (p.Cys342Tyr)single nucleotide variantPathogenicrs121918487GRCh37Chr 10, 123276892: 123276892
2FGFR2NM_000141.4(FGFR2): c.1024T> C (p.Cys342Arg)single nucleotide variantPathogenicrs121918488GRCh37Chr 10, 123276893: 123276893
3FGFR2NM_000141.4(FGFR2): c.1021A> C (p.Thr341Pro)single nucleotide variantPathogenicrs121918495GRCh37Chr 10, 123276896: 123276896
4FGFR2NM_000141.4(FGFR2): c.870G> C (p.Trp290Cys)single nucleotide variantPathogenicrs121918499GRCh37Chr 10, 123279562: 123279562
5FGFR2NM_000141.4(FGFR2): c.817_819delGAC (p.Asp273del)deletionPathogenicrs121918503GRCh37Chr 10, 123279613: 123279615
6FGFR2NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro)single nucleotide variantPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
7FGFR2FGFR2, IVSAS, G-A, -1single nucleotide variantPathogenic
8FGFR2FGFR2, 10-BP DEL/3-BP INS, NT952indelPathogenic
9FGFR2NM_000141.4(FGFR2): c.870G> T (p.Trp290Cys)single nucleotide variantPathogenicrs121918499GRCh37Chr 10, 123279562: 123279562
10FGFR2NM_000141.4(FGFR2): c.1694A> C (p.Glu565Ala)single nucleotide variantPathogenicrs121918506GRCh37Chr 10, 123256215: 123256215
11FGFR2FGFR2, IVSDS, A-G, +3single nucleotide variantPathogenic
12FGFR2NM_000141.4(FGFR2): c.962A> C (p.Asp321Ala)single nucleotide variantPathogenicrs121918510GRCh37Chr 10, 123276955: 123276955
13FGFR1NM_023110.2(FGFR1): c.755C> G (p.Pro252Arg)single nucleotide variantPathogenicrs121909627GRCh37Chr 8, 38282208: 38282208

Expression for genes affiliated with Infectious Mononucleosis

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Expression patterns in normal tissues for genes affiliated with Infectious Mononucleosis

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Pathways for genes affiliated with Infectious Mononucleosis

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Pathways related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FGFR1, FGFR2
2
Show member pathways
9.9FGFR1, FGFR2
39.9FGFR1, FGFR2
49.7IL2RB, CD40LG
5
Show member pathways
9.4FGFR1, FGFR2, CD79A
69.2FGFR1, FGFR2, IL2RB, SH2D1A
7
Show member pathways
8.7IL2RB, CD4, FGFR2, FGFR1
8
Show member pathways
8.7IL2RB, CD4, FGFR2, FGFR1
9
Show member pathways
8.7IL2RB, CD4, FGFR2, FGFR1
10
Show member pathways
8.5CD4, CD79A, FGFR2, FGFR1
11
Show member pathways
8.5IL2RB, CR2, CD79A, FGFR2, FGFR1
128.4SH2D1A, IL2RB, CD4, CD79A
13
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.3CD40LG, CD79A, CD4, CR2
14
Show member pathways
8.3IL2RB, CD4, CD40LG, FGFR2, FGFR1
158.2CD40LG, CD79A, CD4, RAG2
16
Show member pathways
8.2CD4, CD79A, CD40LG, FGFR2, FGFR1

Compounds for genes affiliated with Infectious Mononucleosis

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Compounds related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1pd 1615706110.2FGFR2, FGFR1
2fiin 1 hydrochloride6110.2FGFR2, FGFR1
3su 54026110.2FGFR2, FGFR1
4su54024410.2FGFR1, FGFR2
5pd 17307444 6111.1FGFR1, FGFR2
6palifermin44 1111.1FGFR2, FGFR1
7sulfolipid i4410.0CD40LG, CD79A
8sandoglobulin4410.0CD79A, CD40LG
9streptavidin449.7FGFR2, CR2, IL2RB
10gamma globulin449.6CD40LG, CD79A
11mycophenolate mofetil44 50 1111.5CD40LG, CD79A, IL2RB
12ivig449.5IL2RB, CD79A, CD40LG
13cytidine44 24 1111.4RAG2, CD79A, CD40LG
14agar449.4FGFR1, FGFR2, CD40LG, CD79A
15suramin44 28 1111.4CD79A, FGFR2, FGFR1
16dextran sulfate449.4CD4, CD40LG, FGFR1
17azathioprine44 2 50 1112.3IL2RB, CD79A, FGFR2
18vitamin b12449.3CD40LG, CD79A, GUSB
19ganglioside449.2CD4, CD40LG, FGFR2
20n acetylcysteine449.2FGFR2, CD40LG, CD79A, IL2RB
21erythromycin44 2 50 1112.2GUSB, IL2RB, CD40LG, FGFR2
22hemocyanin449.2CD40LG, CD79A, CD4
23mannan449.2CD40LG, CD79A, CD4
24okt3449.2IL2RB, CR2, CD79A, CD40LG
25paraffin449.0FGFR2, CD40LG, CD79A, CR2
26lactulose449.0CD79A, GUSB
2712-o-tetradecanoylphorbol 13-acetate449.0FGFR1, FGFR2, CD4, IL2RB
28aspirin44 50 28 2411.9GUSB, IL2RB, CD79A, CD40LG
29vegf448.9IL2RB, CD79A, CD40LG, FGFR2, FGFR1
30cyclosporin a44 28 6110.9IL2RB, CR2, CD79A, CD40LG
31proline448.8TPI1, IL2RB, CD4, FGFR2
32neopterin448.8CD40LG, CD79A, CD4, IL2RB
33phosphotyrosine448.8SH2D1A, IL2RB, CD4, FGFR2, FGFR1
34estrogen448.7CR2, CD79A, CD40LG, FGFR2, FGFR1
35retinoic acid44 249.7IL2RB, CD79A, CD40LG, FGFR2, FGFR1
36histamine44 28 2410.7GUSB, IL2RB, CD79A, CD40LG, FGFR1
37creatinine448.6GUSB, TPI1, IL2RB, CD79A, CD40LG
38dopamine44 28 24 1111.6GUSB, CD79A, CD40LG, FGFR1
39phosphatidylinositol448.5IL2RB, CR2, CD4, FGFR2, FGFR1
40lactate448.4GUSB, TPI1, IL2RB, CD79A, CD40LG, FGFR1
41threonine448.3SH2D1A, IL2RB, CR2, CD4, FGFR2, FGFR1
42cysteine448.2TPI1, CD4, CD79A, CD40LG, FGFR2, FGFR1
43polysaccharide448.2FGFR1, FGFR2, CD40LG, CD79A, CD4, IL2RB
44pge2448.1GUSB, IL2RB, CD4, CD79A, CD40LG
45genistein44 28 61 2 24 1113.1GUSB, IL2RB, CD4, CD40LG, FGFR2, FGFR1
46heparin44 28 24 1111.0GUSB, CD4, CD79A, CD40LG, FGFR2, FGFR1
47tyrosine447.9SH2D1A, TPI1, IL2RB, CR2, CD4, FGFR2
48glutamate447.7GUSB, TPI1, CD4, CD79A, CD40LG, FGFR2
49calcium44 50 24 1110.6GUSB, SH2D1A, IL2RB, CR2, CD4, FGFR2
50serine447.4TPI1, IL2RB, CR2, RAG2, CD4, CD40LG

GO Terms for genes affiliated with Infectious Mononucleosis

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Cellular components related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098977.6CD40LG, CD79A, CD4, CR2, IL2RB
2plasma membraneGO:0058867.3CR2, CD4, CD79A, CD40LG, FGFR2, FGFR1

Biological processes related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:03560710.2FGFR1, FGFR2
2ventricular zone neuroblast divisionGO:02184710.1FGFR2, FGFR1
3positive regulation of phospholipase activityGO:01051810.1FGFR1, FGFR2
4mesenchymal cell differentiationGO:04876210.1FGFR1, FGFR2
5lung-associated mesenchyme developmentGO:06048410.1FGFR1, FGFR2
6branching involved in salivary gland morphogenesisGO:06044510.1FGFR2, FGFR1
7positive regulation of cardiac muscle cell proliferationGO:06004510.0FGFR1, FGFR2
8skeletal system morphogenesisGO:04870510.0FGFR2, FGFR1
9positive regulation of cell cycleGO:0457879.9FGFR1, FGFR2
10ureteric bud developmentGO:0016579.9FGFR1, FGFR2
11midbrain developmentGO:0309019.8FGFR1, FGFR2
12positive regulation of mesenchymal cell proliferationGO:0020539.6FGFR1, FGFR2
13B cell proliferationGO:0421009.4CR2, CD79A, CD40LG
14B cell differentiationGO:0301838.9CD40LG, CD79A, RAG2, CR2
15innate immune responseGO:0450878.7FGFR1, FGFR2, CD4, CR2

Molecular functions related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.9FGFR1, FGFR2
2fibroblast growth factor bindingGO:0171349.9FGFR2, FGFR1
3transmembrane signaling receptor activityGO:0048888.6CD79A, CD4, CR2
4protein homodimerization activityGO:0428038.3CD4, FGFR2, FGFR1, CR2

Products for genes affiliated with Infectious Mononucleosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Infectious Mononucleosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet