ACS5
MCID: INF030
MIFTS: 78

Infectious Mononucleosis (ACS5) malady

Infectious diseases, Eye diseases, Bone diseases, Fetal diseases, Endocrine diseases categories

Summaries for Infectious Mononucleosis

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Pfeiffer syndrome is a disorder that affects the bones in the skull, hands and feet. signs and symptoms can include craniosynostosis, which prevents normal skull growth and affects the shape of the head and face; distinctive facial features including bulging and wide-set eyes, a high forehead, an underdeveloped upper jaw, and a beaked nose; hearing loss; and dental problems. other features may include broad and deviated thumbs and great toes; brachydactyly; and syndactyly. it is caused by mutations in the fgfr1 or fgfr2 genes and is inherited in an autosomal dominant manner. the syndrome is divided into 3 subtypes (types 1, 2 and 3) based on the presence and severity of signs and symptoms. management typically includes various surgical interventions. last updated: 5/2/2011

MalaCards: Infectious Mononucleosis, also known as pfeiffer syndrome, is related to craniosynostosis and crouzon syndrome, and has symptoms including fatigue, lymphadenopathy and splenomegaly. An important gene associated with Infectious Mononucleosis is FGFR1 (fibroblast growth factor receptor 1), and among its related pathways are NF-KappaB Family Pathway and Regulation of Actin Cytoskeleton. The compounds SU4984 and pd 161570 have been mentioned in the context of this disorder. Affiliated tissues include pharynx, bone and spleen.

Disease Ontology:8 A viral infectious disease that results in inflammation, located in pharynx, has material basis in human herpesvirus 4 and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly.

Genetics Home Reference:21 Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face. Pfeiffer syndrome also affects bones in the hands and feet.

MedlinePlus:33 Infectious mononucleosis, or "mono", is an infection usually caused by the epstein-barr virus. the virus spreads through saliva, which is why it's sometimes called "kissing disease." mono occurs most often in teens and young adults. however, you can get it at any age. symptoms of mono include fever sore throat swollen lymph glands sometimes you may also have a swollen spleen. serious problems are rare. a blood test can show if you have mono. most people get better in two to four weeks. however, you may feel tired for a few months afterward. treatment focuses on helping symptoms and includes medicines for pain and fever, warm salt water gargles and plenty of rest and fluids.

Wikipedia:63 Infectious mononucleosis (IM; also known as mono, glandular fever, Pfeiffer\'s disease, Filatov\'s... more...

Description from OMIM:46 101600

Aliases & Classifications for Infectious Mononucleosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 9diseasecard, 63Wikipedia, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 48Orphanet, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
pfeiffer syndrome:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

infectious mononucleosis 8 10 44 33 60
pfeiffer syndrome 8 9 63 42 22 21 46 44 48
craniofacial-skeletal-dermatologic dysplasia 21 46 60
acs5 42 21 48
pfeiffer type acrocephalosyndactyly 42 60
acrocephalosyndactyly, type v 63 21
noack syndrome 63 21
acrocephalopolysyndactyly type iv 60
gammaherpesviral mononucleosis 8
acrocephalosyndactylia type v 8
acrocephalosyndactyly, type 5 42
acrocephalosyndactyly type 5 48
pfeiffer's disease 8
filatov's disease 8
monocytic angina 8
glandular fever 8
mononucleosis 8
acs v 21


External Ids:

Disease Ontology8 DOID:8568, DOID:14705
NCIt39 C34726
ICD9CM27 075
OMIM46 101600
MESH via Orphanet35 C538582
ICD10 via Orphanet26 Q87.0
SNOMED-CT via Orphanet57 70410008
UMLS via Orphanet61 C2931888
ICD1025 B27, B27.0

Related Diseases for Infectious Mononucleosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Infectious Mononucleosis:



Diseases related to infectious mononucleosis

Clinical Features for Infectious Mononucleosis

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Sources:
46OMIM, 8Disease Ontology
See all sources

Clinical features from OMIM:

101600

Clinical synopsis from OMIM:

101600

Symptoms:

8 (show all 27)
  • fatigue
  • lymphadenopathy
  • splenomegaly
  • high forehead
  • fever
  • short stature/dwarfism/nanism
  • hip dislocation/dysplasia/coxa valga/coxa vara/coxa plana
  • syndactyly of fingers/interdigital palm
  • short hand/brachydactyly
  • broad nasal root
  • hypertelorism
  • turricephaly/oxycephaly/acrocephaly
  • autosomal dominant inheritance
  • broad/bifid thumb
  • ptosis
  • symphalangy of fingers
  • clinodactyly of fifth finger
  • flat face
  • carpal bones fusion/synostosis
  • lordosis
  • short neck
  • high vaulted/narrow palate
  • short philtrum
  • mouth held open
  • prognathism/prognathia
  • facial structural asymmetry/facial hemiatrophy/facial hemihypertrophy
  • flat cheek bones/malar hypoplasia

Drugs & Therapeutics for Infectious Mononucleosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Infectious Mononucleosis

Drug clinical trials:

Search ClinicalTrials for Infectious Mononucleosis

Search NIH Clinical Center for Infectious Mononucleosis

Search CenterWatch for Infectious Mononucleosis

Genetic Tests for Infectious Mononucleosis

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Sources:
22GTR
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Genetic tests related to Infectious Mononucleosis:

id Genetic test Affiliating Genes
1 Pfeiffer Syndrome22

Anatomical Context for Infectious Mononucleosis

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Infectious Mononucleosis:

32
Bone, Spleen, Testes, T cells, Eye, Monocytes, B cells, Tonsil, Liver, Lymph node, Lung, Colon, Tongue, Thyroid, Breast, Skin

FMA organs/tissues related to Infectious Mononucleosis:

14
Pharynx

Animal Models for Infectious Mononucleosis or affiliated genes

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Publications for Infectious Mononucleosis

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Sources:
50PubMed
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Articles related to Infectious Mononucleosis:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Neurocognitive disturbances associated with acute infectious mononucleosis, Ross River fever and Q fever: A preliminary investigation of inflammatory and genetic correlates. (24211375)
2014
2
Incidence of rash after amoxicillin treatment in children with infectious mononucleosis. (23589810)
2013
3
Spontaneous splenic rupture resulted from infectious mononucleosis. (22288057)
2012
4
Orthostatic tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis. (22850676)
2012
5
Hemorrhagic shock as a sequela of splenic rupture in a patient with infectious mononucleosis: focus on the potential role of salicylates. (22431933)
2012
6
Hypoalbuminaemia is an independent predictor for hemophagocytic lymphohistiocytosis in childhood Epstein-Barr virus-associated infectious mononucleosis. (22897479)
2012
7
Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus. (21327688)
2011
8
Maternal and perinatal factors associated with hospitalised infectious mononucleosis in children, adolescents and young adults: record linkage study. (21356092)
2011
9
HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma. (20308568)
2010
10
Infectious mononucleosis in university students in the United kingdom: evaluation of the clinical features and consequences of the disease. (20121570)
2010
11
Evaluation of an immunofiltration assay that detects immunoglobulin M antibodies against the ZEBRA protein for the diagnosis of Epstein-Barr virus infectious mononucleosis in immunocompetent patients. (19403783)
2009
12
Erythema multiforme-like lesions in the course of infectious mononucleosis. (21886730)
2009
13
Infection of neonates with murine gammaherpesvirus 68 results in enhanced viral persistence in lungs and absence of infectious mononucleosis syndrome. (18420788)
2008
14
Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis. (18032491)
2008
15
Acute hemolytic anemia following infectious mononucleosis. (17449408)
2007
16
Sports medicine pearls and pitfalls--defending the spleen: return to play after infectious mononucleosis. (17376331)
2007
17
Increasing incidence of severe Epstein-Barr virus-related infectious mononucleosis: surveillance study. (16672427)
2006
18
Prevotella bivia necrobacillosis following infectious mononucleosis. (16316686)
2006
19
Infectious mononucleosis-like syndrome and gastrointestinal disorders in acute acquired cytomegalovirus infection. (16049613)
2005
20
Apoptosis in infectious mononucleosis: its detection with the Beckman Coulter GenS hematology analyzer. (15790546)
2005
21
Epstein-Barr virus infectious mononucleosis. (15508538)
2004
22
Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine. (12786839)
2003
23
Epstein-Barr virus-associated infectious mononucleosis in Chinese children. (14614370)
2003
24
Spontaneous splenic capsule rupture complicating infectious mononucleosis. (14527069)
2003
25
Unexpected death due to infectious mononucleosis. (12064653)
2002
26
Hematopoietic and lymphatic cancers in relatives of patients with infectious mononucleosis. (11983756)
2002
27
Subpopulation composition of peripheral blood lymphocytes in children with infectious mononucleosis. (12459870)
2002
28
The molecular characterization of fatal infectious mononucleosis. (11939733)
2002
29
Lymph node infarction associated with infectious mononucleosis: report of a case resembling lymph node infarction associated with malignant lymphoma. (12232580)
2002
30
Azithromycin-induced rash in infectious mononucleosis. (12587634)
2002
31
Chromosome aberrations, apoptosis, and DNA repair in peripheral blood lymphocytes in children with infectious mononucleosis. (12360352)
2002
32
Infectious mononucleosis. A clinical review. (12420480)
2001
33
Accumulation of p53 in infectious mononucleosis tissues. (11112215)
2000
34
Infectious mononucleosis in middle age. (9952206)
1999
35
Acute monoarthritis from infectious mononucleosis. (10460051)
1999
36
A boy with fatal infectious mononucleosis suspected as the first Japanese case of X-linked lymphoproliferative syndrome. (10225392)
1998
37
Infectious mononucleosis complicated by transverse myelitis: detection of the viral genome by polymerase chain reaction in the cerebrospinal fluid. (9352459)
1997
38
What every pediatrician should know about infectious mononucleosis in adolescents. (9400586)
1997
39
Spontaneous splenic rupture in infectious mononucleosis: a review. (9493849)
1997
40
Infectious mononucleosis: recognizing the condition, 'reactivating' the patient. (20086982)
1996
41
Atypical clonal T-cell proliferation in infectious mononucleosis. (9152971)
1996
42
BLT-esterase in infectious mononucleosis. (7743659)
1995
43
The membranous tonsillitis during infectious mononucleosis is nevertheless of bacterial origin. (8444556)
1993
44
Successful plasmapheresis in corticosteroid-resistant hemolysis in infectious mononucleosis: role of autoantibodies against triosephosphate isomerase. (1466197)
1992
45
Infectious mononucleosis complicated by necrotizing epiglottitis, dysphagia, and pneumonia. (2736980)
1989
46
Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome. (3579509)
1987
47
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency. (4686857)
1973
48
Generalized cytomegalic inclusion disease presenting an infectious mononucleosis syndrome (so-called cytomegalovirus mononucleosis) in a previously healthy adult--an autopsy study. (4350607)
1972
49
Acquired Pelger-HuA5183182)
1967
50
Suppurative lymphadenitis concomitant with infectious mononucleosis. (13002790)
1952

Genetic Variations for Infectious Mononucleosis

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Infectious Mononucleosis:

62 (show all 38)
id Symbol AA change Variation ID SNP ID
1FGFR1p.Pro252ArgVAR_004111
2FGFR1p.Pro252ArgVAR_004111
3FGFR2p.Ser252TrpVAR_004115
4FGFR2p.Ser252TrpVAR_004115
5FGFR2p.Cys278PheVAR_004121
6FGFR2p.Cys278PheVAR_004121
7FGFR2p.Trp290CysVAR_004124
8FGFR2p.Trp290CysVAR_004124
9FGFR2p.Asp321AlaVAR_004129
10FGFR2p.Asp321AlaVAR_004129
11FGFR2p.Thr341ProVAR_004135
12FGFR2p.Thr341ProVAR_004135
13FGFR2p.Cys342ArgVAR_004137
14FGFR2p.Cys342ArgVAR_004137
15FGFR2p.Cys342SerVAR_004138
16FGFR2p.Cys342SerVAR_004138
17FGFR2p.Cys342TyrVAR_004139
18FGFR2p.Cys342TyrVAR_004139
19FGFR2p.Ala344ProVAR_004141
20FGFR2p.Ala344ProVAR_004141
21FGFR2p.Ser351CysVAR_004143
22FGFR2p.Ser351CysVAR_004143
23FGFR2p.Val359PheVAR_004146
24FGFR2p.Val359PheVAR_004146
25FGFR2p.Ala172PheVAR_017259
26FGFR2p.Ala172PheVAR_017259
27FGFR2p.Tyr340CysVAR_017269
28FGFR2p.Tyr340CysVAR_017269
29FGFR2p.Cys342GlyVAR_017270
30FGFR2p.Cys342GlyVAR_017270
31FGFR2p.Tyr375CysVAR_017275
32FGFR2p.Tyr375CysVAR_017275
33FGFR2p.Glu565GlyVAR_017277
34FGFR2p.Glu565GlyVAR_017277
35FGFR2p.Lys641ArgVAR_017278
36FGFR2p.Lys641ArgVAR_017278
37FGFR2p.Gly663GluVAR_017280
38FGFR2p.Gly663GluVAR_017280

Expression for genes affiliated with Infectious Mononucleosis

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1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Infectious Mononucleosis

Search GEO for disease gene expression data for Infectious Mononucleosis.

Pathways for genes affiliated with Infectious Mononucleosis

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 53Reactome, 59Tocris Bioscience, 49PharmGKB, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1FGFR1, FGFR2
2
Hide members
9.1FGFR1, FGFR2
3
Hide members
9.1FGFR2, FGFR1
4
Hide members
9.1FGFR1, FGFR2
5
Hide members
9.1FGFR1, FGFR2
6
Hide members
9.1FGFR1, FGFR2
7
Hide members
9.1FGFR2, FGFR1
8
Hide members
9.1FGFR1, FGFR2
9
Hide members
9.1FGFR1, FGFR2
10
Hide members
9.1FGFR1, FGFR2
119.1FGFR1, FGFR2
129.1FGFR2, FGFR1
13
Hide members
9.1FGFR1, FGFR2
14
Hide members
9.1FGFR2, FGFR1
15
Hide members
9.1FGFR1, FGFR2
16
Hide members
9.1FGFR1, FGFR2
179.1FGFR1, FGFR2
189.1FGFR2, FGFR1
19
Hide members
9.1FGFR1, FGFR2
20
Hide members
9.1FGFR1, FGFR2
219.1FGFR1, FGFR2
229.1FGFR2, FGFR1
23
Development FGF-family signaling
Hide members
9.1FGFR2, FGFR1
24
Hide members
9.1FGFR1, FGFR2
259.1FGFR1, FGFR2
26
Hide members
9.1FGFR1, FGFR2
279.1FGFR1, FGFR2
289.1FGFR1, FGFR2

Compounds for genes affiliated with Infectious Mononucleosis

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Sources:
11DrugBank, 59Tocris Bioscience, 44Novoseek, 24HMDB, 28IUPHAR, 2BitterDB, 49PharmGKB
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Compounds related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1SU4984119.5FGFR1, FGFR2
2pd 161570599.5FGFR2, FGFR1
3fiin 1 hydrochloride599.5FGFR2, FGFR1
4su 5402599.5FGFR2, FGFR1
5su5402449.5FGFR1, FGFR2
6pd 17307444 5910.5FGFR2, FGFR1
7palifermin44 1110.4FGFR1, FGFR2
8Ponatinib 119.4FGFR1, FGFR2
9Regorafenib119.4FGFR2, FGFR1
10chondroitin sulfate44 2410.4FGFR1, FGFR2
11suramin44 28 1111.4FGFR1, FGFR2
12bromodeoxyuridine449.4FGFR2, FGFR1
13heparan sulfate44 2410.4FGFR1, FGFR2
14glyceraldehyde 3-phosphate449.4FGFR1, FGFR2
15phenylalanine449.3FGFR2, FGFR1
16agar449.3FGFR2, FGFR1
17phosphotyrosine449.3FGFR2, FGFR1
18ribonucleic acid449.2FGFR2, FGFR1
1912-o-tetradecanoylphorbol 13-acetate449.2FGFR1, FGFR2
20polysaccharide449.1FGFR1, FGFR2
21genistein44 28 59 2 11 2414.1FGFR1, FGFR2
22paclitaxel44 49 1111.0FGFR2, FGFR1
23pd 98,059448.8FGFR1, FGFR2

GO Terms for genes affiliated with Infectious Mononucleosis

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16Gene Ontology
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Cellular components related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.1FGFR1, FGFR2

Biological processes related to Infectious Mononucleosis according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:0356079.5FGFR1, FGFR2
2ventricular zone neuroblast divisionGO:0218479.5FGFR1, FGFR2
3positive regulation of phospholipase activityGO:0105189.5FGFR1, FGFR2
4mesenchymal cell differentiationGO:0487629.5FGFR2, FGFR1
5lung-associated mesenchyme developmentGO:0604849.5FGFR1, FGFR2
6branching involved in salivary gland morphogenesisGO:0604459.5FGFR1, FGFR2
7positive regulation of cardiac muscle cell proliferationGO:0600459.5FGFR2, FGFR1
8positive regulation of cell cycleGO:0457879.5FGFR1, FGFR2
9skeletal system morphogenesisGO:0487059.4FGFR1, FGFR2
10midbrain developmentGO:0309019.4FGFR2, FGFR1
11positive regulation of mesenchymal cell proliferationGO:0020539.4FGFR1, FGFR2
12ureteric bud developmentGO:0016579.4FGFR1, FGFR2
13peptidyl-tyrosine phosphorylationGO:0181089.4FGFR2, FGFR1
14inner ear morphogenesisGO:0424729.4FGFR1, FGFR2
15positive regulation of MAPK cascadeGO:0434109.4FGFR1, FGFR2
16phosphatidylinositol-mediated signalingGO:0480159.4FGFR2, FGFR1
17insulin receptor signaling pathwayGO:0082869.3FGFR1, FGFR2
18protein autophosphorylationGO:0467779.3FGFR1, FGFR2
19fibroblast growth factor receptor signaling pathwayGO:0085439.3FGFR2, FGFR1
20Fc-epsilon receptor signaling pathwayGO:0380959.2FGFR1, FGFR2
21epidermal growth factor receptor signaling pathwayGO:0071739.2FGFR1, FGFR2
22angiogenesisGO:0015259.1FGFR2, FGFR1
23positive regulation of cell proliferationGO:0082849.1FGFR1, FGFR2
24in utero embryonic developmentGO:0017019.0FGFR1, FGFR2
25neurotrophin TRK receptor signaling pathwayGO:0480118.8FGFR1, FGFR2

Molecular functions related to Infectious Mononucleosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.1FGFR1, FGFR2
2heparin bindingGO:0082019.1FGFR1, FGFR2
3fibroblast growth factor bindingGO:0171349.0FGFR1, FGFR2
4protein tyrosine kinase activityGO:0047138.8FGFR1, FGFR2

Products for genes affiliated with Infectious Mononucleosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Infectious Mononucleosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet