MCID: INF034
MIFTS: 44

Infective Endocarditis malady

Summaries for Infective Endocarditis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Infective endocarditis (ie) is an infection of the inner lining of the heart chambers (endocardium) and valves. this condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. ie is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. ie can damage the heart and cause serious and sometimes fatal complications. it can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. common symptoms of ie are fever and other flu-like symptoms, but signs and symptoms can vary. it can also cause problems in many other parts of the body besides the heart. ie is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue. last updated: 3/2/2011

MalaCards: Infective Endocarditis, also known as endocarditis, infective, is related to rheumatic disease and bacterial meningitis. An important gene associated with Infective Endocarditis is TNNI3 (troponin I type 3 (cardiac)), and among its related pathways are Phagocytosis of Microbes and Phagosome. The compounds valine and endotoxin have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A heart disease involving inflammation of the endocardium (inner layer of the heart) caused by bacterial infection.

Wikipedia:64 Infective endocarditis is a form of endocarditis, or inflammation, of the inner tissue of the heart... more...

Aliases & Classifications for Infective Endocarditis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

infective endocarditis 8 43 10
endocarditis, infective 43
endocarditis infective 45
bacterial endocarditis 61


External Ids:

Disease Ontology8 DOID:0060000

Related Diseases for Infective Endocarditis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatic disease30.6APOH, CRP, FCGR2A
2bacterial meningitis30.5TLR2, LBP, CRP, LACTB
3bacteremia30.4MBL2, LBP, CRP, LACTB
4rheumatic fever30.4MBL2, CRP
5kawasaki disease30.4CRP, MBL2
6stroke, ischemic30.3SERPINC1, APOH
7coronary heart disease30.2TNNI3, CRP, ITGB3, SERPINC1
8tuberculosis30.2TLR2, MBL2, CRP, LACTB
9vasculitis30.2CRP, APOH, MBL2
10arthritis30.1TLR2, LBP, CRP, FCGR2A, LACTB
11sepsis30.1TLR2, MBL2, LBP, CRP, FCGR2A, LACTB
12hepatitis b30.0MBL2
13amyloidosis30.0CRP
14ankylosing spondylitis30.0CRP
15nephritis30.0APOH, FCGR2A
16coronary thrombosis30.0SERPINC1, ITGB3
17thyroiditis29.9MBL2
18systemic lupus erythematosus29.9FCGR2A, CRP
19septic arthritis29.9CRP, LACTB
20acute myocardial infarction29.9SERPINC1, CRP, TNNI3
21thrombocytopenia29.9SERPINC1, FCGR2A, ITGB3, APOH
22septic shock29.9TLR2, MBL2, LBP, CRP, LACTB, SERPINC1
23ventricular septal defect10.4
24splenic abscess10.4
25mitral valve prolapse10.4
26pancytopenia10.3
27aortic aneurysm10.3
28marfan syndrome10.3
29hypertrophic cardiomyopathy10.3
30gerbode defect10.3
31discitis10.2
32q fever10.2
33discrete subaortic stenosis10.2
34tricuspid valve stenosis10.2
35aortitis10.2
36marantic endocarditis10.2
37mitral valve stenosis10.2
38pyomyositis10.2
39atrioventricular block10.1
40crescentic glomerulonephritis10.1
41cardiac tamponade10.1
42acalculous cholecystitis10.1
43coronary aneurysm10.1
44splenic infarction10.1
45cortical blindness10.1
46n syndrome10.1
47coronary artery aneurysm10.1
48blindness10.1
49cryoglobulinemia10.0
50membranoproliferative glomerulonephritis10.0

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to infective endocarditis

Clinical Features for Infective Endocarditis

Drugs & Therapeutics for Infective Endocarditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Infective Endocarditis

Drug clinical trials:

Search ClinicalTrials for Infective Endocarditis

Search NIH Clinical Center for Infective Endocarditis

Search CenterWatch for Infective Endocarditis

Genetic Tests for Infective Endocarditis

Anatomical Context for Infective Endocarditis

Animal Models for Infective Endocarditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Infective Endocarditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.3MBL2, APOH, LBP, CRP, ITGB3, DLL1
2MP:00053878.0AQP9, TLR2, MBL2, LBP, CRP, ITGB3

Publications for Infective Endocarditis

Sources:
51PubMed
See all sources

Articles related to Infective Endocarditis:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
Impact of antimicrobial therapy on prognosis of patients requiring valve surgery during active infective endocarditis. (23141030)
2014
2
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
3
Evaluation of Vegetation Size and its Relationship with Embolism in Infective Endocarditis: A Real-time Three-dimensional Transesophageal Echocardiography Study. (24214886)
2013
4
One-and-a-half syndrome: a less appreciated emergency in native valve infective endocarditis. (23083887)
2013
5
Effectiveness of ampicillin plus ceftriaxone compared to ampicillin plus gentamicin for treating Enterococcus faecalis infective endocarditis: a noninferiority question not yet properly investigated. (23704125)
2013
6
Pasteurella multocida infective endocarditis in an immunocompetent patient complicated by rhabdomyolysis and permanent hearing loss. (24023475)
2013
7
Mortality and neurological complications after early or late surgery for infective endocarditis and stroke. (23985344)
2013
8
Early surgery reduces mortality in patients with infective endocarditis: insight from a meta-analysis. (23642830)
2013
9
A patient with infective endocarditis caused by community-acquired Pseudomonas aeruginosa infection. (23728567)
2013
10
What is the effect of penicillin dosing interval on outcomes in streptococcal infective endocarditis? (23766487)
2013
11
Pacemaker pocket displacement as a symptom of lead dependent infective endocarditis. (24297754)
2013
12
Intracardiac damage of silicone insulation of a single lead and infective endocarditis. (24197598)
2013
13
Neurologic complications of infective endocarditis. (23588927)
2013
14
Factors influencing the sensitivity of 18F-FDG PET/CT in the detection of infective endocarditis. (23640469)
2013
15
Three-dimensional echocardiographic evaluation of an anterior mitral leaflet perforation and aortic vegetation due to infective endocarditis. (23128553)
2013
16
Superior mesenteric artery aneurysm in a patient with infective endocarditis. (23870496)
2013
17
Awareness and knowledge of prophylaxis for infective endocarditis in patients with severe rheumatic heart disease. (23951767)
2013
18
NICE guidance on antibiotic prophylaxis to prevent infective endocarditis: a survey of clinicians' attitudes. (23286921)
2013
19
Mild renal dysfunction on admission is an important prognostic predictor in patients with infective endocarditis: a retrospective single-center study. (23676584)
2013
20
Aortic valve replacement and concomitant coronary artery bypass grafting in a patient with infective endocarditis and anomalous origin of the right coronary artery from the opposite sinus of valsalva. (23196657)
2013
21
Late Streptococcus bovis infection of total knee replacement complicated by infective endocarditis and associated with colonic ulcers. (23744853)
2013
22
Infective endocarditis in congenital heart disease: a frequent community-acquired complication. (22956474)
2013
23
Contemporary drug treatment of infective endocarditis. (23640269)
2013
24
Clinical characteristics and thrombolytic outcomes of infective endocarditis-associated stroke. (23983869)
2012
25
Diagnosis of infective endocarditis: comparison of the LightCycler SeptiFast real-time PCR with blood culture. (22403141)
2012
26
Vancomycin AUC24/MIC ratio in patients with complicated bacteremia and infective endocarditis due to methicillin-resistant Staphylococcus aureus and its association with attributable mortality during hospitalization. (22123681)
2012
27
Early surgery for infective endocarditis. (23034032)
2012
28
The changing epidemiology of infective endocarditis: the paradox of prophylaxis in the current and future eras. (22624838)
2012
29
High-dose daptomycin for cardiac implantable electronic device-related infective endocarditis. (22100575)
2012
30
Infective endocarditis in infancy after complete atrioventricular septal defect repair. (23804699)
2012
31
Acute infective endocarditis caused by Delftia acidovorans, a rare pathogen complicating intravenous drug use. (22933597)
2012
32
Aorto-atrial fistula in the absence of infective endocarditis: diagnosis by 2- and 3-dimensional transesophageal echocardiography. (22412254)
2012
33
Usefulness of 16S rDNA sequencing for the diagnosis of infective endocarditis caused by Corynebacterium diphtheriae. (22538997)
2012
34
Lead-dependent infective endocarditis complicated by septic emboli. (21769790)
2011
35
Management of neurological complications of infective endocarditis in ICU patients. (21906336)
2011
36
Cerebral microbleeds predict impending intracranial hemorrhage in infective endocarditis. (22057098)
2011
37
Long-term survival of salvage cardiac transplantation for infective endocarditis. (22051318)
2011
38
Infective endocarditis in a child caused by Cardiobacterium hominis after right ventricular outflow tract reconstruction using an expanded tetrafluoroethylene conduit. (21674312)
2011
39
Takayasu arteritis initially mimicking infective endocarditis. (22084654)
2011
40
Lesson of the month (2). An unique presentation of infective endocarditis. (22268325)
2011
41
Infective endocarditis caused by Erysipelothrix rhusiopathiae involving three native valves. (21850630)
2011
42
Reversible Cortical Blindness as a Prominent Manifestation of Cerebral Embolism due to Infective Endocarditis. (20811562)
2010
43
A case of intra-cardiac right-sided mural infective endocarditis associated with ventricular septal defect despite prophylactic antibiotics: a case report. (20541971)
2010
44
Successful repair for a giant coronary artery aneurysm with coronary arteriovenous fistula complicated by both right- and left-sided infective endocarditis. (19830518)
2009
45
Patients with infective endocarditis and increased cardiac troponin I levels have a higher incidence of in-hospital mortality and valve replacement than those with normal cardiac troponin I levels. (18682663)
2009
46
Splenic abscess complicating infective endocarditis: three case reports. (18274196)
2007
47
Streptococcus sinensis sp. nov., a novel species isolated from a patient with infective endocarditis. (11880397)
2002
48
Thirty-year incidence of infective endocarditis after surgery for congenital heart defect. (9486754)
1998
49
Fatal hemopericardium due to ruptured solitary myocardial abscess unassociated with infective endocarditis. (3219208)
1988
50
Acquired cor triatriatum (left ventricular false aneurysm): complication of active infective endocarditis of the aortic valve with ring abscess treated by valve replacement. (7102518)
1982

Genetic Variations for Infective Endocarditis

Expression for genes affiliated with Infective Endocarditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for genes affiliated with Infective Endocarditis

Sources:
52QIAGEN, 30KEGG
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Pathways related to Infective Endocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FCGR2A, ITGB3, TLR2
29.7FCGR2A, ITGB3, MBL2, TLR2

Compounds for genes affiliated with Infective Endocarditis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Infective Endocarditis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1valine4510.6ODC1
2endotoxin4510.5LBP, APOH
3meropenem4510.3LACTB, MBL2
4polymyxin b4510.3MBL2, TLR2, LBP
5aopp4510.3APOH, CRP
6estrogen4510.3APOH, MBL2
7tirofiban45 1111.3SERPINC1, ITGB3, CRP
8aspartate4510.2ODC1, LBP, MBL2
9peptidoglycan45 2911.2TLR2, MBL2, LBP
10etanercept45 50 1112.2FCGR2A, APOH, CRP
11ceftazidime45 1111.2LACTB, MBL2
12clopidogrel50 45 11 2413.2SERPINC1, CRP, ITGB3
13Alpha-D-Mannose1110.2APOH, SERPINC1, MBL2
14heparin45 29 11 2413.2FCGR2A, APOH, LBP
15gabexate mesilate4510.2CRP, SERPINC1
16imipenem4510.2MBL2, LACTB, SERPINC1
17p0034510.2APOH
18hydroxychloroquine45 1111.2APOH, CRP
19lipoteichoic acid4510.2MBL2, TLR2, LBP, APOH
20abciximab45 1111.1FCGR2A, ITGB3, CRP, SERPINC1
21cefotaxime45 1111.1TLR2, LACTB
22prednisolone45 29 1112.1CRP, APOH, MBL2, FCGR2A
23rituximab45 50 1112.1FCGR2A, APOH, CRP
24betacarotene4510.1ODC1, APOH, CRP
25alpha tocopherol4510.1APOH, ODC1
26homocysteine45 2411.1LBP, APOH, CRP, SERPINC1
27mannose4510.1APOH, TLR2, MBL2, FCGR2A
28latex4510.1TLR2, CRP, APOH, MBL2
29ivig4510.0GTF3A, APOH, CRP, FCGR2A
30prostacyclin4510.0SERPINC1, APOH, CRP, FCGR2A
31folate4510.0APOH, CRP, ODC1, SERPINC1
32ceftriaxone45 1111.0LACTB, CRP
33polysaccharide4510.0SERPINC1, FCGR2A, LBP, MBL2, TLR2
34aspirin45 50 29 2412.9SERPINC1, ITGB3, CRP, APOH, ODC1
35chloramphenicol45 2 1111.8ODC1, SERPINC1, LACTB, CRP
36creatinine459.8SERPINC1, MBL2, CRP, LBP, APOH, TNNI3
37serine459.7GTF3A, FCGR2A, LBP, LACTB, TLR2
38lactate459.7TNNI3, CRP, AQP9, ODC1, APOH
39cholesterol45 29 11 2412.7LBP, FCGR2A, APOH, MBL2, CRP, TLR2
40azithromycin45 1110.6CRP, LACTB
41alanine459.5TLR2, CRP, ITGB3, SERPINC1, LBP, GTF3A
42steroid459.5ITGB3, APOH, SRA1, GTF3A, MBL2
43atp45 2910.4APOH, ITGB3, FCGR2A, MBL2, S100A11, TLR2
44glucose459.3ITGB3, MBL2, TLR2, GTF3A, APOH, AQP9
45fibrinogen459.3LBP, CRP, ITGB3, SERPINC1, GTF3A, APOH
46lipid459.2FCGR2A, LECT1, ITGB3, CRP, TLR2, APOH
47vegf459.1TLR2, MBL2, APOH, CRP, ITGB3, LECT1

GO Terms for genes affiliated with Infective Endocarditis

Sources:
16Gene Ontology
See all sources

Cellular components related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.3CEACAM8, SERPINC1, CRP, LBP, APOH, MBL2

Biological processes related to Infective Endocarditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.1ITGB3, CRP
2cellular response to lipoteichoic acidGO:07122310.1LBP, TLR2
3positive regulation of chemokine productionGO:03272210.1LBP, TLR2
4opsonizationGO:00822810.1MBL2, LBP, CRP
5negative regulation of growth of symbiont in hostGO:04413010.1LBP, MBL2, TLR2
6acute-phase responseGO:00695310.0MBL2, LBP, CRP
7positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR2, LBP
8defense response to Gram-positive bacteriumGO:0508309.9CRP, LBP, MBL2, TLR2
9negative regulation of macrophage derived foam cell differentiationGO:0107459.8ITGB3, CRP

Molecular functions related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:07089110.0LBP, TLR2
2calcium-dependent protein bindingGO:0483069.6TNNI3, MBL2, S100A11
3protein bindingGO:0055158.0APOH, TNNI3, MBL2, S100A11, LBP, CRP

Products for genes affiliated with Infective Endocarditis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Infective Endocarditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet