MCID: INF034
MIFTS: 50

Infective Endocarditis malady

Summaries for Infective Endocarditis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Infective endocarditis (ie) is an infection of the inner lining of the heart chambers (endocardium) and valves. this condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. ie is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. ie can damage the heart and cause serious and sometimes fatal complications. it can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. common symptoms of ie are fever and other flu-like symptoms, but signs and symptoms can vary. it can also cause problems in many other parts of the body besides the heart. ie is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue. last updated: 3/2/2011

MalaCards: Infective Endocarditis, also known as endocarditis, infective, is related to endocarditis and bacterial meningitis. An important gene associated with Infective Endocarditis is TNNI3 (troponin I type 3 (cardiac)), and among its related pathways are Phagocytosis of Microbes and Phagosome. The compounds valine and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A heart disease involving inflammation of the endocardium (inner layer of the heart) caused by bacterial infection.

Wikipedia:63 Infective endocarditis is a form of endocarditis, or inflammation, of the inner tissue of the heart... more...

Aliases & Classifications for Infective Endocarditis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

infective endocarditis 8 42 10
endocarditis, infective 42
endocarditis infective 44
bacterial endocarditis 60


External Ids:

Disease Ontology8 DOID:0060000

Related Diseases for Infective Endocarditis

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17GeneCards, 18GeneDecks
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Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1endocarditis32.0GTF3A, LACTB
2bacterial meningitis30.6TLR2, LBP, CRP, LACTB
3glomerulonephritis30.5FCGR2A, MBL2
4rheumatic fever30.3MBL2, CRP
5kawasaki disease30.3CRP, MBL2
6osteomyelitis30.3LACTB, CRP
7stroke, ischemic30.3SERPINC1, APOH
8myocardial infarction30.2SERPINC1, ITGB3, CRP, LBP, TNNI3
9meningitis30.2TLR2, MBL2, LBP, CRP, FCGR2A, LACTB
10hepatitis30.2TLR2
11disseminated intravascular coagulation30.2SERPINC1, LBP
12tuberculosis30.2TLR2, MBL2, CRP, LACTB
13rheumatoid arthritis30.2TLR2, MBL2, APOH, LBP, CRP, ITGB3
14pulmonary embolism30.1SERPINC1, APOH
15prostatitis30.1LACTB
16vasculitis30.1CRP, APOH, MBL2
17arthritis30.1TLR2, LBP, CRP, FCGR2A, LACTB
18hepatitis b30.0MBL2
19amyloidosis30.0CRP
20ankylosing spondylitis30.0CRP
21coronary thrombosis30.0SERPINC1, ITGB3
22retinal artery occlusion29.9APOH
23myocarditis29.9TNNI3
24purpura29.9SERPINC1
25thyroiditis29.9MBL2
26systemic lupus erythematosus29.9FCGR2A, CRP
27influenza29.9LACTB, MBL2
28heart valve disease29.9APOH, LECT1
29lupus erythematosus29.9SERPINC1, APOH
30septic arthritis29.9CRP, LACTB
31pyelonephritis29.9CRP, LACTB
32acute myocardial infarction29.9SERPINC1, CRP, TNNI3
33thrombocytopenia29.9SERPINC1, FCGR2A, ITGB3, APOH
34peritonitis29.9TLR2, LBP, CRP, LACTB
35pneumonia29.9TLR2, MBL2, LBP, CRP, LACTB
36leukemia29.9ODC1, TLR2, MBL2, ITGB3, DLL1, LACTB
37cerebritis10.5
38ventricular septal defect10.4
39splenic abscess10.4
40mitral valve prolapse10.3
41pancytopenia10.3
42aortic aneurysm10.3
43hypertrophic cardiomyopathy10.3
44diffuse glomerulonephritis10.2
45hemolytic anemia10.2
46discitis10.2
47discrete subaortic stenosis10.2
48tricuspid valve stenosis10.2
49aortitis10.2
50marantic endocarditis10.2

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to infective endocarditis

Clinical Features for Infective Endocarditis

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Drugs & Therapeutics for Infective Endocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Infective Endocarditis

Drug clinical trials:

Search ClinicalTrials for Infective Endocarditis

Search NIH Clinical Center for Infective Endocarditis

Search CenterWatch for Infective Endocarditis

Genetic Tests for Infective Endocarditis

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Anatomical Context for Infective Endocarditis

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32MalaCards
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MalaCards organs/tissues related to Infective Endocarditis:

32
Heart, Brain, Kidney, Colon, Liver, Skin, Testes, Thyroid, Spleen, Prostate

Animal Models for Infective Endocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Infective Endocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.3MBL2, APOH, LBP, CRP, ITGB3, DLL1
2MP:00053878.0AQP9, TLR2, MBL2, LBP, CRP, ITGB3

Publications for Infective Endocarditis

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50PubMed
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Articles related to Infective Endocarditis:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
Potential involvement of collagen-binding proteins of Streptococcus mutans in infective endocarditis. (22998492)
2013
2
Infective endocarditis in previously healthy children with structurally normal hearts. (23483241)
2013
3
Early surgery for native valve infective endocarditis. (23425501)
2013
4
Infective endocarditis presenting as an isolated aneurysm of the posterior mitral leaflet. (23218466)
2013
5
An unusual case of infective endocarditis: annulus vegetation. (23322308)
2013
6
A multicentre evaluation of the effectiveness and safety of high-dose daptomycin for the treatment of infective endocarditis. (23928022)
2013
7
GPIb VNTR C/C genotype may predict embolic events in infective endocarditis. (23611001)
2013
8
Infective endocarditis in children with congenital heart disease: cumulative incidence and predictors. (24060942)
2013
9
Underlying heart disease and microbiological spectrum of adult infective endocarditis in one Chinese university hospital: a 10-year retrospective study. (23869480)
2013
10
Reconstruction of anterior mitral leaflet using autologous pericardial patch combined with posterior leaflet sliding for active infective endocarditis. (23612922)
2013
11
Current outcomes for tricuspid valve infective endocarditis surgery in North America. (23968767)
2013
12
Factors influencing the sensitivity of 18F-FDG PET/CT in the detection of infective endocarditis. (23640469)
2013
13
Changing Spectrum of Infective Endocarditis in Children: A 30 Years Experiences from a Tertiary Care Center in Taiwan. (24378945)
2013
14
Infectious endocarditis detected by PET/CT in a patient with a prosthetic knee infection: case report and review of the literature. (23427876)
2013
15
Assessment of knowledge of dental staff at a saudi arabian university regarding the prophylaxis for infective endocarditis. (23986793)
2013
16
Brain MRI findings in neurologically asymptomatic patients with infective endocarditis. (23639563)
2013
17
Clinical practice. Infective endocarditis. (23574121)
2013
18
Sudden death in patients with infective endocarditis: findings from a large cohort study. (22759277)
2013
19
Dentigenous infectious foci - a risk factor of infective endocarditis. (22293883)
2012
20
Infective endocarditis in intravenous drug abusers: an update. (22714640)
2012
21
Vancomycin AUC24/MIC ratio in patients with complicated bacteremia and infective endocarditis due to methicillin-resistant Staphylococcus aureus and its association with attributable mortality during hospitalization. (22123681)
2012
22
The need for a specific risk prediction system in native valve infective endocarditis surgery. (22536134)
2012
23
Cystatin C in a composite risk score for mortality in patients with infective endocarditis: a cohort study. (22798251)
2012
24
What is the optimal timing for surgery in infective endocarditis with cerebrovascular complications? (22108925)
2012
25
Impact of infectious diseases service consultation on diagnosis of infective endocarditis. (22176644)
2012
26
Infective endocarditis or myxoma? Description of a patient with new diagnosis of congestive heart failure. (23167154)
2012
27
Prevention of infective endocarditis: between progress in scientific knowledge and the lack of randomized trials. (23041166)
2012
28
Subaortic membrane with rupture of sinus of Valsalva presented with infective endocarditis and its thromboembolic complications. (22346146)
2012
29
A surgical case of mitral regurgitation due to active infective endocarditis with idiopathic thrombocytopenic purpura. (21881359)
2011
30
Management of neurological complications of infective endocarditis in ICU patients. (21906336)
2011
31
Cerebral microbleeds predict impending intracranial hemorrhage in infective endocarditis. (22057098)
2011
32
Parents' knowledge of infective endocarditis in children with congenital heart disease. (22086578)
2011
33
Rupture of an infectious intracranial aneurysm involving two parent arteries after surgical treatment of infective endocarditis. (21206450)
2011
34
Surgical treatment in active infective endocarditis: results of a four-year experience. (22347645)
2011
35
Intracranial hemorrhage in infective endocarditis: A case report. (22263076)
2011
36
Reversible Cortical Blindness as a Prominent Manifestation of Cerebral Embolism due to Infective Endocarditis. (20811562)
2010
37
Streptococcus mutans infective endocarditis complicated by vertebral discitis following dental treatment without antibiotic prophylaxis. (20616190)
2010
38
Streptococcus oralis endocarditis presenting as infective discitis in an edentulous patient. (18684532)
2009
39
Infective endocarditis associated with spondylodiscitis and frequent secondary epidural abscess. (17720227)
2008
40
Extremely late pacemaker-infective endocarditis due to Stenotrophomonas maltophilia. (18073476)
2008
41
Infected splenic artery aneurysm with associated splenic abscess formation secondary to bacterial endocarditis: case report and review of the literature. (17466802)
2007
42
Pro-inflammatory cytokines IL6, TNF-alpha, IL1beta, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis. (17586049)
2007
43
Coexistent congenital aortic defects, aneurysm of sinus of valsalva, atrial septal defect and infective endocarditis: a case report. (17203799)
2006
44
Cholesterol embolism after cardiac catheterization mimicking infective endocarditis. (16293917)
2005
45
Septic discitis as a complication of infective endocarditis caused by Streptococcus oralis. (12610830)
2003
46
Streptococcus sinensis sp. nov., a novel species isolated from a patient with infective endocarditis. (11880397)
2002
47
Pseudomonas mendocina as a cause of chronic infective endocarditis in a patient with situs inversus. (11737094)
2001
48
Aortitis with multiple aneurysms mimicking infective endocarditis. (10024866)
1999
49
Disseminated Mycobacterium chelonae infection resulting in endocarditis. (8953086)
1996
50
Mixed infection in subacute bacterial endocarditis; report of two cases. (18879124)
1948

Genetic Variations for Infective Endocarditis

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Expression for genes affiliated with Infective Endocarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for genes affiliated with Infective Endocarditis

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51QIAGEN, 29KEGG
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Pathways related to Infective Endocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FCGR2A, ITGB3, TLR2
29.7FCGR2A, ITGB3, MBL2, TLR2

Compounds for genes affiliated with Infective Endocarditis

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Infective Endocarditis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1valine4410.6ODC1
2endotoxin4410.5LBP, APOH
3meropenem4410.3LACTB, MBL2
4polymyxin b4410.3TLR2, MBL2, LBP
5aopp4410.3APOH, CRP
6estrogen4410.3APOH, MBL2
7tirofiban44 1111.3SERPINC1, ITGB3, CRP
8aspartate4410.2LBP, MBL2, ODC1
9peptidoglycan44 2811.2LBP, MBL2, TLR2
10etanercept44 49 1112.2FCGR2A, CRP, APOH
11ceftazidime44 1111.2MBL2, LACTB
12clopidogrel49 44 11 2413.2SERPINC1, ITGB3, CRP
13Alpha-D-Mannose1110.2SERPINC1, APOH, MBL2
14heparin44 28 11 2413.2FCGR2A, LBP, APOH
15hydroxychloroquine44 1111.2APOH, CRP
16imipenem4410.2SERPINC1, LACTB, MBL2
17p0034410.2APOH
18lipoteichoic acid4410.2TLR2, MBL2, APOH, LBP
19gabexate mesilate4410.1CRP, SERPINC1
20abciximab44 1111.1CRP, ITGB3, FCGR2A, SERPINC1
21cefotaxime44 1111.1LACTB, TLR2
22prednisolone44 28 1112.1FCGR2A, CRP, APOH, MBL2
23rituximab44 49 1112.1APOH, CRP, FCGR2A
24betacarotene4410.1CRP, APOH, ODC1
25alpha tocopherol4410.1APOH, ODC1
26homocysteine44 2411.1APOH, LBP, CRP, SERPINC1
27mannose4410.1TLR2, MBL2, APOH, FCGR2A
28latex4410.1TLR2, MBL2, APOH, CRP
29ivig4410.0APOH, CRP, FCGR2A, GTF3A
30prostacyclin4410.0SERPINC1, FCGR2A, CRP, APOH
31folate4410.0ODC1, APOH, CRP, SERPINC1
32ceftriaxone44 1111.0CRP, LACTB
33polysaccharide4410.0SERPINC1, FCGR2A, LBP, MBL2, TLR2
34aspirin44 49 28 2412.9ODC1, APOH, CRP, ITGB3, SERPINC1
35chloramphenicol44 2 1111.8ODC1, CRP, LACTB, SERPINC1
36creatinine449.8MBL2, TNNI3, APOH, LBP, CRP, SERPINC1
37serine449.7TLR2, LBP, FCGR2A, LACTB, GTF3A
38lactate449.7ODC1, TNNI3, APOH, CRP, AQP9
39cholesterol44 28 11 2412.7TLR2, MBL2, APOH, LBP, CRP, FCGR2A
40azithromycin44 1110.6CRP, LACTB
41alanine449.5TLR2, LBP, CRP, ITGB3, SERPINC1, GTF3A
42steroid449.5GTF3A, SRA1, ITGB3, APOH, MBL2
43atp44 2810.4TLR2, S100A11, MBL2, APOH, ITGB3, FCGR2A
44glucose449.3TLR2, MBL2, APOH, CRP, ITGB3, GTF3A
45fibrinogen449.3GTF3A, TLR2, MBL2, APOH, LBP, CRP
46lipid449.2TLR2, MBL2, APOH, LBP, CRP, ITGB3
47vegf449.1TLR2, MBL2, APOH, CRP, ITGB3, LECT1

GO Terms for genes affiliated with Infective Endocarditis

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16Gene Ontology
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Cellular components related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.3CEACAM8, SERPINC1, CRP, LBP, APOH, MBL2

Biological processes related to Infective Endocarditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.1ITGB3, CRP
2cellular response to lipoteichoic acidGO:07122310.1LBP, TLR2
3positive regulation of chemokine productionGO:03272210.1LBP, TLR2
4opsonizationGO:00822810.1MBL2, LBP, CRP
5negative regulation of growth of symbiont in hostGO:04413010.1LBP, MBL2, TLR2
6acute-phase responseGO:00695310.0MBL2, LBP, CRP
7positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR2, LBP
8defense response to Gram-positive bacteriumGO:0508309.9CRP, LBP, MBL2, TLR2
9negative regulation of macrophage derived foam cell differentiationGO:0107459.8ITGB3, CRP

Molecular functions related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:07089110.0LBP, TLR2
2calcium-dependent protein bindingGO:0483069.6TNNI3, MBL2, S100A11
3protein bindingGO:0055158.0APOH, TNNI3, MBL2, S100A11, LBP, CRP

Products for genes affiliated with Infective Endocarditis

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Sources for Infective Endocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet