MCID: INF034
MIFTS: 45

Infective Endocarditis malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Infective Endocarditis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Infective endocarditis (ie) is an infection of the inner lining of the heart chambers (endocardium) and valves. this condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. ie is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. ie can damage the heart and cause serious and sometimes fatal complications. it can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. common symptoms of ie are fever and other flu-like symptoms, but signs and symptoms can vary. it can also cause problems in many other parts of the body besides the heart. ie is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue. last updated: 3/2/2011

MalaCards: Infective Endocarditis, also known as endocarditis, infective, is related to congenital heart disease and meningitis. An important gene associated with Infective Endocarditis is TNNI3 (troponin I type 3 (cardiac)), and among its related pathways are Cytoskeletal Signaling and Ca-dependent events. The compounds abciximab and cytochalasin d have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney.

Disease Ontology:8 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia:65 Infective endocarditis is a form of endocarditis, or inflammation, of the inner tissue of the heart... more...

Aliases & Classifications for Infective Endocarditis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

infective endocarditis 8 43 10
endocarditis, infective 43
endocarditis infective 45
bacterial endocarditis 62


External Ids:

Disease Ontology8 DOID:0060000

Related Diseases for Infective Endocarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1congenital heart disease30.6TNNI3, TNNT2
2meningitis30.3FCGR2A, LBP
3myocardial infarction30.2TNNI3, TNNT2, GP1BA, LBP
4sepsis30.1FCGR2A, GP1BA, LBP
5congestive heart failure30.0TNNI3, TNNT2
6myocarditis30.0TNNI3, TNNT2
7hypertrophic cardiomyopathy30.0TNNI3, TNNT2
8acute myocardial infarction30.0TNNI3, TNNT2
9noonan syndrome30.0TNNI3, TNNT2
10thrombocytopenia30.0GP1BA, FCGR2A
11endocarditis11.4
12aneurysm10.7
13cerebritis10.5
14ventricular septal defect10.4
15mitral valve prolapse10.4
16splenic abscess10.4
17glomerulonephritis10.4
18bacteremia10.3
19rheumatic fever10.3
20kawasaki disease10.3
21gerbode defect10.3
22discitis10.2
23aortitis10.2
24tricuspid valve stenosis10.2
25discrete subaortic stenosis10.2
26osteomyelitis10.2
27atrioventricular block10.1
28cardiac tamponade10.1
29acalculous cholecystitis10.1
30rheumatic heart disease10.1
31splenic infarction10.1
32cortical blindness10.1
33crescentic glomerulonephritis10.1
34arthritis10.1
35cholecystitis10.1
36prostatitis10.1
37pulmonary embolism10.1
38vasculitis10.1
39cor triatriatum10.1
40coronary artery aneurysm10.1
41blindness10.1
42intermediate coronary syndrome10.0TNNI3, TNNT2
43familial restrictive cardiomyopathy10.0TNNI3, TNNT2
44familial hypertrophic cardiomyopathy10.0TNNT2, TNNI3
45sudden cardiac death multi-gene panels10.0TNNI3, TNNT2
46duchenne muscular dystrophy10.0TNNI3, TNNT2
47dilated cardiomyopathy10.0TNNI3, TNNT2
48coronary artery disease10.0TNNI3, TNNT2
49vascular disease10.0TNNT2, TNNI3
50cystic fibrosis10.0LBP

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to infective endocarditis

Symptoms for Infective Endocarditis

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Drugs & Therapeutics for Infective Endocarditis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Infective Endocarditis

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

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Anatomical Context for Infective Endocarditis

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Sources:
33MalaCards
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MalaCards organs/tissues related to Infective Endocarditis:

33
Heart, Brain, Kidney, Colon, Liver, Skin, Thyroid, Testes, Spleen, Prostate

Animal Models for Infective Endocarditis or affiliated genes

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Publications for Infective Endocarditis

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Sources:
52PubMed
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Articles related to Infective Endocarditis:

(show top 50)    (show all 580)
idTitleAuthorsYear
1
Double valve replacement and reconstruction of the intervalvular fibrous body in patients with active infective endocarditis. (23644706)
2014
2
Infective endocarditis initially presenting with a dermatomyositis-like syndrome. (24414182)
2014
3
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
4
Left kidney infarction in a patient with native aortic valve infective endocarditis: diagnosis with contrast-enhanced ultrasound. (24432168)
2013
5
Hairy cell leukemia masquerading as infective endocarditis. (24426343)
2013
6
Impact of haplotypes of TNF in the natural course of infective endocarditis. (24165416)
2013
7
Infective endocarditis giving rise to peritonitis in a patient on peritoneal dialysis. (23843595)
2013
8
Evaluation of Vegetation Size and its Relationship with Embolism in Infective Endocarditis: A Real-time Three-dimensional Transesophageal Echocardiography Study. (24214886)
2013
9
Potential involvement of collagen-binding proteins of Streptococcus mutans in infective endocarditis. (22998492)
2013
10
Emergency department diagnosis of infective endocarditis using bedside emergency ultrasound. (23399454)
2013
11
Whole body assessment by A^a8,F-FDG PET in a patient with infective endocarditis. (23636968)
2013
12
Mycotic aneurysm: a rare and dreaded complication of infective endocarditis. (23814229)
2013
13
Infective endocarditis in previously healthy children with structurally normal hearts. (23483241)
2013
14
Pathophysiology of infective endocarditis. (23737237)
2013
15
Early cardiac surgery after ischemic stroke in patients with infective endocarditis may not be safe. (23420815)
2013
16
Inflammatory parameters and prediction of prognosis in infective endocarditis. (23767848)
2013
17
Infective endocarditis in a new immigrant. (23766049)
2013
18
One-and-a-half syndrome: a less appreciated emergency in native valve infective endocarditis. (23083887)
2013
19
Cardiac device infective endocarditis and patient survival. (22910745)
2012
20
Clinical characteristics and thrombolytic outcomes of infective endocarditis-associated stroke. (23983869)
2012
21
Timing for surgery in patients with infective endocarditis and cerebrovascular complications--waiting may be best but results of early surgery are acceptable and improvements in neurology are common. (22219446)
2012
22
Dentigenous infectious foci - a risk factor of infective endocarditis. (22293883)
2012
23
Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels. (22302637)
2012
24
Recurrent Infective endocarditis of the native aortic valve due to ESBL producing Escherichia coli (e coli) after therapeutic ERCP. (22720314)
2012
25
Infective endocarditis and spondylodiscitis due to posterior nasal packing in a patient with a bioprosthetic aortic valve. (22447509)
2012
26
Mycotic Celiac Artery Aneurysm Following Infective Endocarditis: Successful Treatment Using N-butyl Cyanoacrylate with Embolization Coils. (23555513)
2012
27
An atypical presentation of infective endocarditis. (23182295)
2012
28
Long-term outcome of active infective endocarditis with renal insufficiency in cardiac surgery. (22790993)
2012
29
Percutaneous closure of an aorto-atrial fistula after surgery for infective endocarditis. (22721671)
2012
30
Aorto-right atrial fistula secondary to infective endocarditis presenting with cardiogenic shock. (21045716)
2012
31
Diagnosis of infective endocarditis: comparison of the LightCycler SeptiFast real-time PCR with blood culture. (22403141)
2012
32
Novel markers of cerebral embolism in the course of infective endocarditis. (22056473)
2012
33
Value of PCR in surgically treated patients with staphylococcal infective endocarditis: a 4-year retrospective study. (21964590)
2012
34
Successful combination therapy with vancomycin and arbekacin against infective endocarditis caused by MRSA. (22686009)
2011
35
Infective endocarditis in mitral mechanical prosthesis: the role of three-dimensional transoesophageal echocardiography. (21795251)
2011
36
Lead-dependent infective endocarditis complicated by septic emboli. (21769790)
2011
37
A surgical case of mitral regurgitation due to active infective endocarditis with idiopathic thrombocytopenic purpura. (21881359)
2011
38
Surgical treatment for infective endocarditis in elderly patients. (21679726)
2011
39
Infective endocarditis complicated by fatal cerebral hemorrhage revealing an unrepaired univentricular heart in a 19-year-old woman. (21547931)
2011
40
The Streptococcus sanguinis competence regulon is not required for infective endocarditis virulence in a rabbit model. (22039480)
2011
41
Management of neurological complications of infective endocarditis in ICU patients. (21906336)
2011
42
Infective endocarditis: the European viewpoint. (21621720)
2011
43
Intracardiac fistulae: a rare complication of infective endocarditis. (21997657)
2011
44
Recent progress in the understanding of infective endocarditis. (21922184)
2011
45
Prospective study of infective endocarditis from a developing country. (21982654)
2011
46
Surgical treatment of isolated right-sided infective endocarditis. (22199423)
2011
47
Multisite infective endocarditis/endarteritis in a young peripartum patient with patent ductus arteriosus and rheumatic heart valve disease: a case report. (20529109)
2010
48
Crescentic glomerulonephritis in a child with infective endocarditis. (16703379)
2006
49
Exercise-induced mitral regurgitation and antibiotic prophylaxis against infective endocarditis in mitral valve prolapse. (7642881)
1995
50
Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. (1778210)
1991

Variations for Infective Endocarditis

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Expression for genes affiliated with Infective Endocarditis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for genes affiliated with Infective Endocarditis

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Sources:
50PathCards, 5Cell Signaling Technology, 55Reactome, 60Thomson Reuters, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Infective Endocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNNI3, TNNT2
2
Show member pathways
9.5TNNI3, TNNT2
39.5TNNT2, TNNI3
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.5TNNI3, TNNT2
59.5TNNI3, TNNT2
69.5TNNI3, TNNT2
7
Show member pathways
9.5TNNI3, TNNT2
89.0FCGR2A, LBP

Compounds for genes affiliated with Infective Endocarditis

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Infective Endocarditis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1abciximab45 1110.4GP1BA, FCGR2A
2cytochalasin d45 6110.3FCGR2A, GP1BA
3prostacyclin459.3FCGR2A, GP1BA
4valine459.2GP1BA, FCGR2A
5lactate459.2TNNI3, TNNT2, GP1BA
6phenylalanine459.2FCGR2A, GP1BA
7epinephrine45 24 1111.1GP1BA, FCGR2A
8creatinine459.1LBP, TNNT2, TNNI3
9fibrinogen459.0GP1BA, LBP
10alanine459.0LBP, GP1BA, TNNT2
11polysaccharide458.9FCGR2A, LBP
12phosphatidylinositol458.7FCGR2A, GP1BA, LBP
13serine458.5FCGR2A, GP1BA, LBP
14calcium45 51 24 1111.4FCGR2A, TNNI3, TNNT2, GP1BA
15heparin45 29 24 1111.3FCGR2A, TNNT2, GP1BA, LBP

GO Terms for genes affiliated with Infective Endocarditis

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16Gene Ontology
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Cellular components related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:0300179.5TNNI3, TNNT2
2troponin complexGO:0058619.2TNNI3, TNNT2

Biological processes related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5TNNI3, TNNT2
2negative regulation of ATPase activityGO:0327809.4TNNI3, TNNT2
3ventricular cardiac muscle tissue morphogenesisGO:0550109.2TNNI3, TNNT2

Molecular functions related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:0037799.5TNNI3, TNNT2
2troponin C bindingGO:0301729.2TNNI3, TNNT2

Products for genes affiliated with Infective Endocarditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Infective Endocarditis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet