MCID: INF034
MIFTS: 56

Infective Endocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Infective Endocarditis

MalaCards integrated aliases for Infective Endocarditis:

Name: Infective Endocarditis 12 72 49 14 69
Endocarditis, Infective 72 49
Bacterial Endocarditis 69 28
Endocarditis Infective 51

Classifications:



External Ids:

Disease Ontology 12 DOID:0060000

Summaries for Infective Endocarditis

NIH Rare Diseases : 49 Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. IE is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damage the heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue. Last updated: 3/2/2011

MalaCards based summary : Infective Endocarditis, also known as endocarditis, infective, is related to endocarditis and splenic infarction, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Toll-like receptor signaling pathway. The drugs Fosfomycin and Imipenem have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and skin, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia : 72 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Infective Endocarditis

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
# Related Disease Score Top Affiliating Genes
1 endocarditis 30.7 APOH CRP F2 FCGR2A IL6 LBP
2 splenic infarction 30.3 APOH F2
3 pericarditis 30.0 CRP IL6 TNF
4 cardiogenic shock 30.0 CRP IL6
5 heart disease 29.9 CRP F2 IL6 TNF TNNI3
6 retinal artery occlusion 29.9 APOH F2 SERPINE1
7 rheumatic heart disease 29.8 IL6 TLR2 TNF
8 kawasaki disease 29.8 CRP FCGR2A IL6 TNF
9 acute myocardial infarction 29.8 CRP SERPINE1 TNNI3
10 myocarditis 29.7 IL6 TNF TNNI3
11 arteriovenous fistula 29.7 APOH IL6
12 brucellosis 29.6 CRP IL6 TNF
13 pyelonephritis 29.6 CRP IL6 TNF
14 end stage renal failure 29.6 CRP IL6 TNF
15 limb ischemia 29.6 IL6 TNF TNNI3
16 vasculitis 29.6 APOH CRP TNF
17 pneumonia 29.6 CRP IL6 TLR2 TNF
18 temporal arteritis 29.5 APOH CRP IL6
19 stroke, ischemic 29.5 APOH CRP F2 SERPINE1
20 haemophilus influenzae 29.4 TLR2 TNF
21 adult-onset still's disease 29.3 CRP FCGR2A IL6 TNF
22 meningitis 29.3 CRP FCGR2A IL6 TLR2 TNF
23 takayasu arteritis 29.3 CRP FCGR2A IL6 TNF
24 pulmonary embolism 29.3 APOH CRP F2 SERPINE1 TNNI3
25 thrombosis 29.2 APOH F2 GP1BA SERPINE1
26 cerebral artery occlusion 29.0 ODC1 TNF
27 thrombocytopenia 29.0 APOH GP1BA ITGB3
28 peritonitis 28.9 CRP F2 IL6 LBP TLR2 TNF
29 thrombophilia 28.7 APOH F2 SERPINE1
30 systemic lupus erythematosus 28.4 APOH CRP F2 FCGR2A IL6 TNF
31 purpura 28.3 APOH CRP F2 GP1BA ITGB3 TNF
32 myocardial infarction 28.0 CRP F2 GP1BA IL6 ITGB3 SERPINE1
33 orthostatic intolerance 11.4
34 marantic endocarditis 11.4
35 subacute bacterial endocarditis 10.9
36 malignant otitis externa 10.6 CRP F2
37 cold agglutinin disease 10.5 CRP IL6
38 ischemic neuropathy 10.5 CRP F2
39 diabetic foot ulcers 10.5 CRP IL6
40 cryopyrin-associated periodic syndrome 10.5 CRP IL6
41 neutrophilia, hereditary 10.5 CRP IL6
42 acute cholangitis 10.4 CRP IL6
43 blue toe syndrome 10.4 CRP F2 SERPINE1
44 uremic pruritus 10.4 CRP IL6
45 venous insufficiency 10.4 CRP F2 SERPINE1
46 spinal disease 10.4 CRP IL6
47 marburg hemorrhagic fever 10.4 F2 TNF
48 homocysteinemia 10.4 CRP F2 SERPINE1
49 scorpion envenomation 10.4 IL6 TNF
50 castleman disease 10.3 CRP IL6

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to Infective Endocarditis

Symptoms & Phenotypes for Infective Endocarditis

UMLS symptoms related to Infective Endocarditis:


osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 IL6 ITGB3 F2 LBP FCGR2A SERPINE1
2 cardiovascular system MP:0005385 10.03 TLR2 IL6 ITGB3 CRP F2 SERPINE1
3 homeostasis/metabolism MP:0005376 10.02 TLR2 IL6 APOH ITGB3 CRP F2
4 immune system MP:0005387 9.96 TLR2 IL6 ITGB3 CRP F2 LBP
5 digestive/alimentary MP:0005381 9.88 TLR2 IL6 ITGB3 F2 IBSP TNF
6 mortality/aging MP:0010768 9.65 TLR2 IL6 APOH ITGB3 F2 ODC1
7 liver/biliary system MP:0005370 9.63 TLR2 IL6 ITGB3 LBP SERPINE1 TNF
8 respiratory system MP:0005388 9.17 TLR2 IL6 ITGB3 F2 SERPINE1 TNF

Drugs & Therapeutics for Infective Endocarditis

Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fosfomycin Approved Phase 4 23155-02-4 446987
2
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
3
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 14969 441141
4
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Hexetidine Approved, Investigational Phase 4 141-94-6
8 Racepinephrine Approved Phase 4 329-65-7
9
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
10
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2
14 methicillin Phase 4,Phase 3,Phase 2
15 Anesthetics Phase 4,Phase 2
16 Anesthetics, Local Phase 4,Phase 2
17 Anti-Arrhythmia Agents Phase 4,Phase 2
18 Central Nervous System Depressants Phase 4,Phase 2
19 Diuretics, Potassium Sparing Phase 4,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
21 Sodium Channel Blockers Phase 4,Phase 2
22 Adrenergic Agents Phase 4
23 Adrenergic Agonists Phase 4
24 Adrenergic alpha-Agonists Phase 4
25 Adrenergic beta-Agonists Phase 4
26 Anti-Asthmatic Agents Phase 4
27 Anti-Infective Agents, Local Phase 4
28 Autonomic Agents Phase 4,Phase 3
29 Bronchodilator Agents Phase 4
30 Chlorhexidine gluconate Phase 4
31 Dermatologic Agents Phase 4
32 Disinfectants Phase 4
33 Epinephryl borate Phase 4
34 Mydriatics Phase 4
35 Neurotransmitter Agents Phase 4
36 Pharmaceutical Solutions Phase 4
37 Respiratory System Agents Phase 4
38 Vasoconstrictor Agents Phase 4
39 Amoxicillin-Potassium Clavulanate Combination Phase 4
40 beta-Lactamase Inhibitors Phase 4
41 Clavulanic Acid Phase 4
42 Antitubercular Agents Phase 4,Phase 3,Phase 2
43 Gentamicins Phase 4,Phase 3
44
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
45
Netilmicin Approved, Investigational Phase 3 56391-56-1 6857423 441306
46
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
47
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
48
Cloxacillin Approved, Investigational, Vet_approved Phase 3 61-72-3 6098
49
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
50
Ofloxacin Approved Phase 3 82419-36-1 4583

Interventional clinical trials:

(show top 50) (show all 63)

# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Unknown status NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
3 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
4 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
5 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Recruiting NCT01920126 Phase 4 sodium bicarbonate;Saline
6 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
7 Partial Oral Treatment of Endocarditis Recruiting NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
8 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
9 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
10 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
11 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
12 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
13 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Recruiting NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
14 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
15 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Not yet recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
16 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
17 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
18 CopenHeart IE - Integrated Rehabilitation of Patients Treated for Infective Endocarditis Recruiting NCT01512615 Phase 2
19 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
20 Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
21 Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
22 Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
23 Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis Unknown status NCT02033421
24 Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
25 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
26 Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients Unknown status NCT00562653
27 PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
28 Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis Unknown status NCT01916005
29 Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis Completed NCT02940340
30 18-FDG PET/CT Imaging and Clinical Decisions in Infective Endocarditis Completed NCT02287792
31 Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism Completed NCT00947817
32 Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008) Completed NCT03295045
33 Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective Endocaridtis Completed NCT02466139
34 How to Improve Diagnosis in Infective Endocarditis Completed NCT00524212
35 Oral Health Intervention Program for Children With Congenital Heart Defects Completed NCT03311438
36 IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis Completed NCT00144885
37 Outcomes Following Medical or Surgical Management of Endocarditis Completed NCT00166023
38 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068
39 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up Completed NCT01196273
40 Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis Recruiting NCT03266302
41 French National Observatory on Infective Endocarditis Recruiting NCT03272724
42 Clinical Metagenomics of Infective Endocarditis Recruiting NCT03199287
43 Infective Endocarditis in the Elderly Recruiting NCT02910856
44 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Recruiting NCT02887079
45 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Recruiting NCT02856607
46 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Recruiting NCT02698930 dexmedetomidine;Normal saline
47 Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis Recruiting NCT03411499
48 PRetest prObability of Infectious ENDOCARDITIS for Appropriate Criteria Regarding Transesophageal ECHOcardiography in Tertiary Care Facilities (PRO ENDOCARDITIS ECHO-Study) Recruiting NCT03365193
49 Etiology of Endocarditis in Negative Blood Cultures Recruiting NCT02816307
50 Endocarditis Registry of the University Hospital of Cologne (ER-UHC) Recruiting NCT02388893

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

Genetic tests related to Infective Endocarditis:

# Genetic test Affiliating Genes
1 Bacterial Endocarditis 28

Anatomical Context for Infective Endocarditis

MalaCards organs/tissues related to Infective Endocarditis:

38
Heart, Endothelial, Skin, Liver, Brain, Kidney, Colon

Publications for Infective Endocarditis

Articles related to Infective Endocarditis:

(show top 50) (show all 794)
# Title Authors Year
1
Corrigendum to "A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE". [Int. J. Cardiol. Aug 15 2017;241:97-102.]. ( 29398138 )
2018
2
Bioprosthetic Versus Mechanical Valve Replacement for Infective Endocarditis: Focus on Recurrence Rates. ( 29452115 )
2018
3
Marseille scoring system for empiric treatment of infective endocarditis. ( 29397446 )
2018
4
Acquired ventricular septal defect due to infective endocarditis. ( 29440841 )
2018
5
The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review. ( 29413230 )
2018
6
A broad-range PCR technique for the diagnosis of infective endocarditis. ( 29429763 )
2018
7
Utility of cardiac computed tomography scanning in the diagnosis and pre-operative evaluation of patients with infective endocarditis. ( 29450741 )
2018
8
Gemella bergeri infective endocarditis: a case report and brief review of literature. ( 29444729 )
2018
9
Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature. ( 29390976 )
2018
10
A Review of Combination Antimicrobial Therapy for Enterococcus Faecalis Bloodstream Infections and Infective Endocarditis. ( 29390132 )
2018
11
What are the main predictors of in-hospital mortality in patients with infective endocarditis: a review. ( 29382232 )
2018
12
Current knowledge among Japanese experienced general dentists regarding prevention of infective endocarditis. ( 29435864 )
2018
13
Infective endocarditis in a patient with metastatic colorectal cancer. ( 29390605 )
2018
14
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
2018
15
Does antibiotic prophylaxis really prevent streptococci infective endocarditis? ( 29378813 )
2018
16
Outcome of Infective Endocarditis in the Current Era: Early Predictors of Poor Prognosis. ( 29382606 )
2018
17
Prognostic implications of a negative echocardiography in patients with infective endocarditis. ( 29409744 )
2018
18
A pragmatic approach for mortality prediction after surgery in infective endocarditis: Optimizing and refining EuroSCORE. ( 29408350 )
2018
19
Prosthetic Valve Infective Endocarditis With Mycobacterium Fortuitum: Antibiotics Alone Can Be Curative. ( 28688832 )
2017
20
Infective endocarditis, embolic stroke and splenic abscess: a case report. ( 29423161 )
2017
21
Infective endocarditis causing mitral valve stenosis - a rare but deadly complication: a case report. ( 28209176 )
2017
22
Infective endocarditis prophylaxis: a review. ( 28076699 )
2017
23
Effect of perioperative sodium bicarbonate administration on renal function following cardiac surgery for infective endocarditis: a randomized, placebo-controlled trial. ( 28057030 )
2017
24
Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report. ( 29284415 )
2017
25
A risk factor analysis for in-hospital mortality after surgery for infective endocarditis and a proposal of a new predictive scoring system. ( 28054252 )
2017
26
Acalculous cholecystitis in a female with cardiac device-related infective endocarditis. ( 28987045 )
2017
27
Sternoclavicular joint osteomyelitis extending to lung abscess complicated by Staphylococcal infective endocarditis. ( 28660126 )
2017
28
Geotrichum candidum in Infective Endocarditis. ( 28878529 )
2017
29
In silico assessment of virulence factors in strains of Streptococcus oralis and Streptococcus mitis isolated from patients with Infective Endocarditis. ( 28874232 )
2017
30
A chronic hemodialysis patient with isolated pulmonary valve infective endocarditis caused by non-albicans Candida: a rare case and literature review. ( 28874131 )
2017
31
Infective endocarditis and thoracic aortic disease: A review on forgotten psychological aspects. ( 28824792 )
2017
32
Analysis of Short- and Long-term Outcomes of Patients With Surgically Treated Left-sided Infective Endocarditis: A 5-Year Longitudinal Follow-up Study. ( 28935512 )
2017
33
Infective endocarditis caused by Pseudomonas stutzeri in a patient with Marfan syndrome: Case report and brief literature review. ( 28831383 )
2017
34
Evolution of Prognosis inA Left-Sided Infective Endocarditis: A Propensity Score Analysis of 2 Decades. ( 28057237 )
2017
35
Pacemaker lead infective endocarditis in immunocompetent host due to Aspergillus: An uncommon occurrence. ( 28937397 )
2017
36
A Case of Infective Endocarditis and Spinal Epidural Abscess Caused by<i>Streptococcus mitis</i>Bacteremia. ( 29038738 )
2017
37
Triad of infective endocarditis, splenic abscess, and septicemia caused by<i>Brucella melitensis</i>. ( 28966504 )
2017
38
Contribution of Streptococcus mutans Strains with Collagen-Binding Proteins in the Presence of Serum to the Pathogenesis of Infective Endocarditis. ( 28947650 )
2017
39
Antibiotic prophylaxis probably reduces the risk of developing bacteremia in patients at risk of developing infective endocarditis who are undergoing dental extractions. ( 28886792 )
2017
40
Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material. ( 28065906 )
2017
41
Gestational choriocarcinoma complicated by infective endocarditis during chemotherapy. ( 28217736 )
2017
42
Infective endocarditis in patients with cancer: a consequence of invasive procedures or a harbinger of neoplasm?: A prospective, multicenter cohort. ( 28930826 )
2017
43
Magnetic Resonance Imaging Susceptibility-Weighted Imaging Lesion and Contrast Enhancement May Represent Infectious Intracranial Aneurysm in Infective Endocarditis. ( 28848178 )
2017
44
Aortic Valve Infective Endocarditis with an Annular Abscess. ( 28924132 )
2017
45
Hypoprothrombinemia and severe perioperative haemorrhagic complications in cardiac surgery patients treated with high-dose cefazolin for infective endocarditis. ( 28870850 )
2017
46
<i>Staphylococcus aureus</i> Bacteremia Complicated by Psoas Abscess and Infective Endocarditis in a Patient with Atopic Dermatitis. ( 29375918 )
2017
47
Infective Endocarditis Presenting as Bilateral Orbital Cellulitis: An Unusual Case. ( 28721318 )
2017
48
A Curious Case of Blood-Culture-Negative Infective Endocarditis. ( 28943190 )
2017
49
Clinical utility of (18)F-FDG positron emission tomography/computed tomography scan vs. (99m)Tc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis. ( 28050751 )
2017
50
Percutaneous Closure of 2 Paravalvular Leaks and a Gerbode Defect after Mitral Valve Replacement for Infective Endocarditis. ( 28461806 )
2017

Variations for Infective Endocarditis

Expression for Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for Infective Endocarditis

Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 IBSP IL6 ITGB3 TLR2 TNF
2
Show member pathways
12.29 IL6 LBP SERPINE1 TLR2 TNF
3
Show member pathways
12 IL6 ITGB3 TNF TNNI3
4
Show member pathways
11.99 CRP F2 IL6 SERPINE1 TNF
5
Show member pathways
11.95 IL6 LBP TLR2 TNF
6 11.93 IL6 SERPINE1 TNF
7 11.92 FCGR2A ITGB3 TNF
8 11.89 FCGR2A GP1BA ITGB3
9 11.88 IBSP ITGB3 SERPINE1
10 11.87 FCGR2A IL6 TNF
11 11.84 IL6 LBP TNF
12
Show member pathways
11.79 IL6 TLR2 TNF
13 11.76 IL6 SERPINE1 TNF
14
Show member pathways
11.74 F2 GP1BA ITGB3
15 11.73 IL6 TLR2 TNF
16 11.69 IL6 TLR2 TNF
17
Show member pathways
11.66 CRP IL6 LBP
18 11.66 GP1BA IL6 ITGB3 TNF
19 11.64 FCGR2A ITGB3 TLR2
20 11.61 FCGR2A IL6 LBP TLR2 TNF
21 11.46 IBSP ITGB3 SERPINE1
22 11.43 IL6 TLR2 TNF
23 11.36 IL6 TLR2 TNF
24 11.33 GP1BA IL6 TNF
25 11.28 FCGR2A IL6 TLR2 TNF
26 11.09 FCGR2A GP1BA IL6 ITGB3 TNF
27 10.78 CRP IL6 TNF
28 10.75 IBSP ITGB3

GO Terms for Infective Endocarditis

Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 APOH CRP F2 FCGR2A GP1BA ITGB3
2 extracellular region GO:0005576 9.76 APOH CRP F2 IBSP IL6 LBP
3 extracellular space GO:0005615 9.56 APOH CRP F2 IBSP IL6 LBP
4 cell surface GO:0009986 9.1 APOH GP1BA ITGB3 LBP TLR2 TNF

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.92 CRP IL6 TLR2 TNF
2 positive regulation of gene expression GO:0010628 9.92 CRP IL6 TLR2 TNF
3 extracellular matrix organization GO:0030198 9.86 IBSP ITGB3 SERPINE1 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.83 IL6 LBP SERPINE1 TNF
5 platelet activation GO:0030168 9.81 F2 GP1BA IL6 ITGB3
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL6 TLR2 TNF
7 platelet degranulation GO:0002576 9.79 APOH ITGB3 SERPINE1
8 defense response to Gram-negative bacterium GO:0050829 9.75 IL6 LBP SERPINE1
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 LBP TLR2 TNF
10 regulation of blood coagulation GO:0030193 9.67 APOH F2 GP1BA
11 positive regulation of interleukin-6 production GO:0032755 9.67 IL6 LBP TLR2 TNF
12 fibrinolysis GO:0042730 9.65 F2 GP1BA SERPINE1
13 defense response to Gram-positive bacterium GO:0050830 9.65 CRP IL6 LBP TLR2 TNF
14 blood coagulation, intrinsic pathway GO:0007597 9.63 APOH F2 GP1BA
15 acute-phase response GO:0006953 9.62 CRP F2 IL6 LBP
16 negative regulation of blood coagulation GO:0030195 9.61 APOH SERPINE1
17 positive regulation of blood coagulation GO:0030194 9.61 APOH F2 SERPINE1
18 negative regulation of growth of symbiont in host GO:0044130 9.6 LBP TNF
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.59 CRP ITGB3
20 cellular response to lipoteichoic acid GO:0071223 9.58 LBP TLR2
21 negative regulation of fibrinolysis GO:0051918 9.58 APOH F2 SERPINE1
22 opsonization GO:0008228 9.57 CRP LBP
23 positive regulation of STAT protein import into nucleus GO:2000366 9.55 F2 IL6
24 positive regulation of interleukin-8 production GO:0032757 9.46 LBP SERPINE1 TLR2 TNF
25 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
26 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 ITGB3 TNF

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 ITGB3 SERPINE1 TNF
2 lipopeptide binding GO:0071723 8.96 LBP TLR2
3 lipopolysaccharide binding GO:0001530 8.8 F2 LBP TLR2
4 protein binding GO:0005515 10.07 APOH CRP F2 FCGR2A GP1BA IL6

Sources for Infective Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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