MCID: INF034
MIFTS: 45

Infective Endocarditis malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Infective Endocarditis

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NIH Rare Diseases:42 Infective endocarditis (ie) is an infection of the inner lining of the heart chambers (endocardium) and valves. this condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. ie is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. ie can damage the heart and cause serious and sometimes fatal complications. it can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. common symptoms of ie are fever and other flu-like symptoms, but signs and symptoms can vary. it can also cause problems in many other parts of the body besides the heart. ie is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue. last updated: 3/2/2011

MalaCards based summary: Infective Endocarditis, also known as endocarditis, infective, is related to congenital heart disease and meningitis. An important gene associated with Infective Endocarditis is TNNI3 (troponin I type 3 (cardiac)), and among its related pathways are Cytoskeletal Signaling and Ca-dependent events. The compounds abciximab and cytochalasin d have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney.

Disease Ontology:8 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia:65 Infective endocarditis is a form of endocarditis, or inflammation, of the inner tissue of the heart... more...

Aliases & Classifications for Infective Endocarditis

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Infective Endocarditis, Aliases & Descriptions:

Name: Infective Endocarditis 8 42 10
Endocarditis, Infective 42
 
Endocarditis Infective 44
Bacterial Endocarditis 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:0060000

Related Diseases for Infective Endocarditis

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Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1congenital heart disease30.6TNNT2, TNNI3
2meningitis30.3FCGR2A, LBP
3congestive heart failure30.3TNNT2, TNNI3
4myocarditis30.3TNNI3, TNNT2
5hypertrophic cardiomyopathy30.3TNNI3, TNNT2
6acute myocardial infarction30.2TNNI3, TNNT2
7noonan syndrome30.2TNNT2, TNNI3
8thrombocytopenia30.0FCGR2A, GP1BA
9myocardial infarction29.9GP1BA, LBP, TNNT2, TNNI3
10sepsis29.9LBP, GP1BA, FCGR2A
11endocarditis11.4
12aneurysm10.7
13cerebritis10.5
14ventricular septal defect10.5
15mitral valve prolapse10.4
16glomerulonephritis10.4
17splenic abscess10.4
18bacteremia10.3
19rheumatic fever10.3
20kawasaki disease10.3
21gerbode defect10.3
22discrete subaortic stenosis10.2
23discitis10.2
24tricuspid valve stenosis10.2
25osteomyelitis10.2
26cor triatriatum10.2
27intermediate coronary syndrome10.2TNNI3, TNNT2
28familial restrictive cardiomyopathy10.2TNNT2, TNNI3
29familial hypertrophic cardiomyopathy10.2TNNI3, TNNT2
30sudden cardiac death multi-gene panels10.2TNNI3, TNNT2
31duchenne muscular dystrophy10.2TNNI3, TNNT2
32dilated cardiomyopathy10.2TNNT2, TNNI3
33coronary artery anomaly10.2TNNT2, TNNI3
34arthritis10.1
35cerebral hemorrhage10.1
36acalculous cholecystitis10.1
37splenic infarction10.1
38cardiac tamponade10.1
39aortitis10.1
40patent ductus arteriosus10.1
41crescentic glomerulonephritis10.1
42cortical blindness10.1
43atrioventricular block10.1
44cholecystitis10.1
45prostatitis10.1
46pulmonary embolism10.1
47vasculitis10.1
48coronary artery aneurysm10.1
49blindness10.1
50vascular disease10.1TNNT2, TNNI3

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to infective endocarditis

Symptoms for Infective Endocarditis

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Drugs & Therapeutics for Infective Endocarditis

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Drug clinical trials:

Search ClinicalTrials for Infective Endocarditis

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

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Anatomical Context for Infective Endocarditis

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MalaCards organs/tissues related to Infective Endocarditis:

32
Heart, Brain, Kidney, Colon, Liver, Skin, Spleen, Thyroid, Prostate, Testes, Neutrophil

Animal Models for Infective Endocarditis or affiliated genes

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Publications for Infective Endocarditis

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Articles related to Infective Endocarditis:

(show top 50)    (show all 604)
idTitleAuthorsYear
1
Right anterior minithoracotomy versus median sternotomy surgery for native mitral valve infective endocarditis. (25296460)
2014
2
First case of infective endocarditis caused by Helicobacter cinaedi. (25403102)
2014
3
Double valve replacement and reconstruction of the intervalvular fibrous body in patients with active infective endocarditis. (23644706)
2014
4
Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis - Analysis in the International Collaboration of Endocarditis - Prospective Cohort Study. (25389255)
2014
5
Surgical treatment for aortic periannular abscess/pseudoaneurysm caused by infective endocarditis. (23161575)
2013
6
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
7
Left kidney infarction in a patient with native aortic valve infective endocarditis: diagnosis with contrast-enhanced ultrasound. (24432168)
2013
8
Hairy cell leukemia masquerading as infective endocarditis. (24426343)
2013
9
Impact of haplotypes of TNF in the natural course of infective endocarditis. (24165416)
2013
10
Infective endocarditis giving rise to peritonitis in a patient on peritoneal dialysis. (23843595)
2013
11
Evaluation of Vegetation Size and its Relationship with Embolism in Infective Endocarditis: A Real-time Three-dimensional Transesophageal Echocardiography Study. (24214886)
2013
12
Potential involvement of collagen-binding proteins of Streptococcus mutans in infective endocarditis. (22998492)
2013
13
Emergency department diagnosis of infective endocarditis using bedside emergency ultrasound. (23399454)
2013
14
Whole body assessment by A^a8,F-FDG PET in a patient with infective endocarditis. (23636968)
2013
15
Mycotic aneurysm: a rare and dreaded complication of infective endocarditis. (23814229)
2013
16
Infective endocarditis in previously healthy children with structurally normal hearts. (23483241)
2013
17
Pathophysiology of infective endocarditis. (23737237)
2013
18
Early cardiac surgery after ischemic stroke in patients with infective endocarditis may not be safe. (23420815)
2013
19
Inflammatory parameters and prediction of prognosis in infective endocarditis. (23767848)
2013
20
Cardiac device infective endocarditis and patient survival. (22910745)
2012
21
Clinical characteristics and thrombolytic outcomes of infective endocarditis-associated stroke. (23983869)
2012
22
Timing for surgery in patients with infective endocarditis and cerebrovascular complications--waiting may be best but results of early surgery are acceptable and improvements in neurology are common. (22219446)
2012
23
Dentigenous infectious foci - a risk factor of infective endocarditis. (22293883)
2012
24
Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels. (22302637)
2012
25
Recurrent Infective endocarditis of the native aortic valve due to ESBL producing Escherichia coli (e coli) after therapeutic ERCP. (22720314)
2012
26
Infective endocarditis and spondylodiscitis due to posterior nasal packing in a patient with a bioprosthetic aortic valve. (22447509)
2012
27
Mycotic Celiac Artery Aneurysm Following Infective Endocarditis: Successful Treatment Using N-butyl Cyanoacrylate with Embolization Coils. (23555513)
2012
28
An atypical presentation of infective endocarditis. (23182295)
2012
29
Long-term outcome of active infective endocarditis with renal insufficiency in cardiac surgery. (22790993)
2012
30
Percutaneous closure of an aorto-atrial fistula after surgery for infective endocarditis. (22721671)
2012
31
Aorto-right atrial fistula secondary to infective endocarditis presenting with cardiogenic shock. (21045716)
2012
32
Diagnosis of infective endocarditis: comparison of the LightCycler SeptiFast real-time PCR with blood culture. (22403141)
2012
33
Novel markers of cerebral embolism in the course of infective endocarditis. (22056473)
2012
34
Value of PCR in surgically treated patients with staphylococcal infective endocarditis: a 4-year retrospective study. (21964590)
2012
35
Successful combination therapy with vancomycin and arbekacin against infective endocarditis caused by MRSA. (22686009)
2011
36
Infective endocarditis in mitral mechanical prosthesis: the role of three-dimensional transoesophageal echocardiography. (21795251)
2011
37
Lead-dependent infective endocarditis complicated by septic emboli. (21769790)
2011
38
A surgical case of mitral regurgitation due to active infective endocarditis with idiopathic thrombocytopenic purpura. (21881359)
2011
39
Surgical treatment for infective endocarditis in elderly patients. (21679726)
2011
40
Infective endocarditis complicated by fatal cerebral hemorrhage revealing an unrepaired univentricular heart in a 19-year-old woman. (21547931)
2011
41
The Streptococcus sanguinis competence regulon is not required for infective endocarditis virulence in a rabbit model. (22039480)
2011
42
Management of neurological complications of infective endocarditis in ICU patients. (21906336)
2011
43
Infective endocarditis: the European viewpoint. (21621720)
2011
44
Intracardiac fistulae: a rare complication of infective endocarditis. (21997657)
2011
45
Recent progress in the understanding of infective endocarditis. (21922184)
2011
46
Prospective study of infective endocarditis from a developing country. (21982654)
2011
47
Multisite infective endocarditis/endarteritis in a young peripartum patient with patent ductus arteriosus and rheumatic heart valve disease: a case report. (20529109)
2010
48
Crescentic glomerulonephritis in a child with infective endocarditis. (16703379)
2006
49
Exercise-induced mitral regurgitation and antibiotic prophylaxis against infective endocarditis in mitral valve prolapse. (7642881)
1995
50
Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. (1778210)
1991

Variations for Infective Endocarditis

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Expression for genes affiliated with Infective Endocarditis

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Expression patterns in normal tissues for genes affiliated with Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for genes affiliated with Infective Endocarditis

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Pathways related to Infective Endocarditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNNI3, TNNT2
2
Show member pathways
9.5TNNI3, TNNT2
39.5TNNT2, TNNI3
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.5TNNI3, TNNT2
59.5TNNI3, TNNT2
69.5TNNI3, TNNT2
7
Show member pathways
9.5TNNI3, TNNT2
89.0FCGR2A, LBP

Compounds for genes affiliated with Infective Endocarditis

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Compounds related to Infective Endocarditis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1abciximab44 1110.4GP1BA, FCGR2A
2cytochalasin d44 6110.3FCGR2A, GP1BA
3prostacyclin449.3FCGR2A, GP1BA
4valine449.2GP1BA, FCGR2A
5lactate449.2TNNI3, TNNT2, GP1BA
6phenylalanine449.2FCGR2A, GP1BA
7epinephrine44 24 1111.1GP1BA, FCGR2A
8creatinine449.1LBP, TNNT2, TNNI3
9fibrinogen449.0GP1BA, LBP
10alanine449.0LBP, GP1BA, TNNT2
11polysaccharide448.9FCGR2A, LBP
12phosphatidylinositol448.7FCGR2A, GP1BA, LBP
13serine448.5FCGR2A, GP1BA, LBP
14calcium44 50 24 1111.4FCGR2A, TNNI3, TNNT2, GP1BA
15heparin44 28 24 1111.3FCGR2A, TNNT2, GP1BA, LBP

GO Terms for genes affiliated with Infective Endocarditis

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Cellular components related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:0300179.5TNNI3, TNNT2
2troponin complexGO:0058619.2TNNI3, TNNT2

Biological processes related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5TNNI3, TNNT2
2negative regulation of ATPase activityGO:0327809.4TNNI3, TNNT2
3ventricular cardiac muscle tissue morphogenesisGO:0550109.2TNNI3, TNNT2

Molecular functions related to Infective Endocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:0037799.5TNNI3, TNNT2
2troponin C bindingGO:0301729.2TNNI3, TNNT2

Products for genes affiliated with Infective Endocarditis

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Sources for Infective Endocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet