MCID: INF034
MIFTS: 51

Infective Endocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Infective Endocarditis

Aliases & Descriptions for Infective Endocarditis:

Name: Infective Endocarditis 12 50 14 69
Endocarditis, Infective 50
Endocarditis Infective 52
Bacterial Endocarditis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060000

Summaries for Infective Endocarditis

NIH Rare Diseases : 50 infective endocarditis (ie) is an infection of the inner lining of the heart chambers (endocardium) and valves. this condition is sometimes called "endocarditis," although it is important to distinguish it from non-infective endocarditis. ie is caused by bacteria, fungi, or other germs invading the bloodstream and attaching to the heart. ie can damage the heart and cause serious and sometimes fatal complications. it can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. common symptoms of ie are fever and other flu-like symptoms, but signs and symptoms can vary. it can also cause problems in many other parts of the body besides the heart. ie is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue. last updated: 3/2/2011

MalaCards based summary : Infective Endocarditis, also known as endocarditis, infective, is related to lupus erythematosus and pyelonephritis, and has symptoms including osler's nodes An important gene associated with Infective Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Toll-like Receptor Signaling Pathway. The drugs Fosfomycin and Imipenem have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents.

Wikipedia : 71 Infective endocarditis is a form of endocarditis. It is an inflammation of the inner tissues of the... more...

Related Diseases for Infective Endocarditis

Diseases related to Infective Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
id Related Disease Score Top Affiliating Genes
1 lupus erythematosus 29.5 CRP IL6 TNNI3
2 pyelonephritis 29.4 CRP F2 TNF
3 tuberculosis 29.4 IL6 TNF TNNI3
4 limb ischemia 29.3 CRP IL6 TNF
5 calcinosis 29.3 CRP IL6 TNF
6 aortic coarctation 29.3 IL6 TLR2 TNF
7 myocardial infarction 28.5 CRP F2 GP1BA IL6 ITGB3 SERPINE1
8 endocarditis 11.5
9 marantic endocarditis 10.9
10 subacute bacterial endocarditis 10.8
11 orthostatic intolerance 10.8
12 acute infection of pinna 10.3 CRP F2
13 coloboma of iris 10.3 CRP IL6
14 midline cystocele 10.2 CRP F2 SERPINE1
15 cutaneous sclerosis 10.2 CRP IL6
16 aneurysm 10.2
17 xerophthalmia 10.2 CRP F2 SERPINE1
18 citrulline transport defect 10.2 CRP F2
19 shoulder impingement syndrome 10.2 CRP IL6
20 secretory diarrhea myopathy and deafness 10.2 CRP IL6 SERPINE1
21 granulomatous hepatitis 10.2 CRP F2 IL6
22 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
23 neuroaxonal dystrophy 10.2 F2 IL6 SERPINE1
24 epidermolysis bullosa dystrophica, ad 10.2 CRP LBP TLR2
25 gait apraxia 10.2 CRP IL6 SERPINE1
26 vulvitis 10.2 F2 IL6 SERPINE1
27 vascular erectile tumor 10.2 APOH F2
28 adult t-cell leukemia 10.1 CRP SERPINE1 TNNI3
29 dyslexia 5 10.1 IL6 TNF
30 parovarian cyst 10.1 F2 TNF
31 aortic atherosclerosis 10.1 IL6 TNF
32 degenerative disc disease 10.1 IL6 TNF
33 unilateral multicystic dysplastic kidney 10.1 CRP IL6 TNF
34 swine influenza 10.1 CRP IL6 TNF
35 human immunodeficiency virus infectious disease 10.1 CRP IL6 TNF
36 nguyen syndrome 10.1 TLR2 TLR6
37 joint disorders 10.1 CRP IL6 TNF
38 cicatricial lagophthalmos 10.1 CRP IL6 TNF
39 paragonimiasis 10.1 IL6 LBP TLR2
40 benign neonatal seizures 10.1 CRP IL6 TNF
41 neuropathy 10.1 CRP IL6 TNF
42 plummer's disease 10.1 CRP IL6 TNF
43 intestinal disaccharidase deficiency 10.1 APOH CRP F2
44 low anorectal malformation 10.1 F2 FCGR2A TNF
45 pancreas lymphoma 10.1 CRP IL6 TNF
46 follicular adenoma 10.1 CRP IL6 TNF
47 carotenemia 10.1 CRP IL6 TNF
48 myiasis 10.1 CRP IL6 TNF
49 blepharochalasis 10.1 CRP IL6 TNF
50 choroiditis 10.1 CRP IL6 TNF

Graphical network of the top 20 diseases related to Infective Endocarditis:



Diseases related to Infective Endocarditis

Symptoms & Phenotypes for Infective Endocarditis

UMLS symptoms related to Infective Endocarditis:


osler's nodes

MGI Mouse Phenotypes related to Infective Endocarditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 F2 FCGR2A GP1BA IL6 ITGB3 LBP
2 cardiovascular system MP:0005385 9.97 CRP F2 IL6 ITGB3 SERPINE1 TLR2
3 homeostasis/metabolism MP:0005376 9.96 APOH CRP F2 GP1BA IL6 ITGB3
4 immune system MP:0005387 9.85 TNF CRP F2 FCGR2A IL6 ITGB3
5 liver/biliary system MP:0005370 9.43 SERPINE1 TLR2 TNF IL6 ITGB3 LBP
6 respiratory system MP:0005388 9.17 F2 IL6 ITGB3 SERPINE1 TLR2 TNF

Drugs & Therapeutics for Infective Endocarditis

Drugs for Infective Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fosfomycin Approved Phase 4 23155-02-4 446987
2
Imipenem Approved Phase 4 74431-23-5 104838
3
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 441141 14969
4
Rifampin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
5
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
6
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
7
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
8
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
9
Hexetidine Approved Phase 4 141-94-6
10
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
11
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
13
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
14
Cephalexin Approved, Vet_approved Phase 4 15686-71-2 27447
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
16 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2
18 methicillin Phase 4,Phase 3,Phase 2
19 Antitubercular Agents Phase 4,Phase 3,Phase 2
20 Anesthetics Phase 4,Phase 2
21 Anesthetics, Local Phase 4,Phase 2
22 Anti-Arrhythmia Agents Phase 4,Phase 2
23 Central Nervous System Depressants Phase 4,Phase 2
24 Diuretics, Potassium Sparing Phase 4,Phase 2
25 Peripheral Nervous System Agents Phase 4,Phase 2
26 Sodium Channel Blockers Phase 4,Phase 2
27 beta-Lactams Phase 4
28 Lactams Phase 4
29 Adrenergic Agents Phase 4
30 Adrenergic Agonists Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Adrenergic beta-Agonists Phase 4
33 Anti-Asthmatic Agents Phase 4
34 Anti-Infective Agents, Local Phase 4
35 Autonomic Agents Phase 4
36 Bronchodilator Agents Phase 4
37 Chlorhexidine gluconate Phase 4
38 Dermatologic Agents Phase 4
39 Disinfectants Phase 4
40 Epinephryl borate Phase 4
41 Mydriatics Phase 4
42 Neurotransmitter Agents Phase 4
43 Pharmaceutical Solutions Phase 4
44 Racepinephrine Phase 4
45 Respiratory System Agents Phase 4
46 Vasoconstrictor Agents Phase 4
47 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
48 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
49 Fluoroquinolones Phase 4,Phase 3
50 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 76)
id Name Status NCT ID Phase
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Unknown status NCT00871104 Phase 4
3 Partial Oral Treatment of Endocarditis Unknown status NCT01375257 Phase 4
4 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Unknown status NCT02443064 Phase 4
5 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
6 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4
7 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
8 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4
9 Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia Completed NCT00548002 Phase 4
10 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Recruiting NCT01920126 Phase 4
11 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4
12 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Not yet recruiting NCT03112356 Phase 4
13 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4
14 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4
15 Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Terminated NCT00401960 Phase 4
16 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4
17 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4
18 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3
19 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3
20 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3
21 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3
22 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3
23 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Recruiting NCT02208063 Phase 3
24 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3
25 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Not yet recruiting NCT03138733 Phase 3
26 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2
27 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2
28 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
29 CopenHeart IE - Integrated Rehabilitation of Patients Treated for Infective Endocarditis Recruiting NCT01512615 Phase 2
30 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
31 Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia Recruiting NCT03163446 Phase 2
32 Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis Not yet recruiting NCT03148756 Phase 2
33 Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia Terminated NCT00695903 Phase 2
34 Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia Terminated NCT01975662 Phase 2
35 Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
36 Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis Unknown status NCT02033421
37 Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients Unknown status NCT00562653
38 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
39 PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
40 Positron Emission Tomography of Infection and Vasculitis Unknown status NCT01878721
41 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
42 Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections Unknown status NCT01301638
43 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
44 18-FDG PET/CT Imaging and Clinical Decisions in Infective Endocarditis Completed NCT02287792
45 How to Improve Diagnosis in Infective Endocarditis Completed NCT00524212
46 Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism Completed NCT00947817
47 IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis Completed NCT00144885
48 Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective Endocaridtis Completed NCT02466139
49 Outcomes Following Medical or Surgical Management of Endocarditis Completed NCT00166023
50 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up Completed NCT01667068

Search NIH Clinical Center for Infective Endocarditis

Genetic Tests for Infective Endocarditis

Anatomical Context for Infective Endocarditis

MalaCards organs/tissues related to Infective Endocarditis:

39
Heart, Brain, Kidney, Colon, Skin, Liver, Neutrophil

Publications for Infective Endocarditis

Articles related to Infective Endocarditis:

(show top 50) (show all 732)
id Title Authors Year
1
Clinical utility of (18)F-FDG positron emission tomography/computed tomography scan vs. (99m)Tc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis. ( 28050751 )
2017
2
Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material. ( 28065906 )
2017
3
Infective endocarditis and risk of death after cardiac implantable electronic device implantation: a nationwide cohort study. ( 28073883 )
2017
4
Infective endocarditis prophylaxis: a review. ( 28076699 )
2017
5
Evolution of Prognosis inA Left-Sided Infective Endocarditis: A Propensity Score Analysis of 2 Decades. ( 28057237 )
2017
6
A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis. ( 28064105 )
2017
7
When the heart rules the head: ischaemic stroke and intracerebral haemorrhage complicating infective endocarditis. ( 28049738 )
2017
8
Prognostic value of N-terminal prohormone brain natriuretic peptide for in-hospital and long-term outcomes in patients with infective endocarditis. ( 28067531 )
2017
9
A risk factor analysis for in-hospital mortality after surgery for infective endocarditis and a proposal of a new predictive scoring system. ( 28054252 )
2017
10
Effect of perioperative sodium bicarbonate administration on renal function following cardiac surgery for infective endocarditis: a randomized, placebo-controlled trial. ( 28057030 )
2017
11
International guideline changes and the incidence of infective endocarditis: a systematic review. ( 27621836 )
2016
12
Left main occlusion secondary to infective endocarditis vegetation: "The unusual suspect". ( 28063812 )
2016
13
Metastatic Calcinosis of Aortic Valve Secondary to Renal Failure Mimicking Infective Endocarditis. ( 27738529 )
2016
14
Recurrent prosthetic mitral valve infective endocarditis and perivalvular abscess: first description by PET/CT angiography. ( 27178270 )
2016
15
Infective endocarditis following Melody valve implantation: comparison with a surgical cohort. ( 27161361 )
2016
16
Predisposing cardiac conditions, interventional procedures, and antibiotic prophylaxis among patients with infective endocarditis. ( 27595678 )
2016
17
Managing infective endocarditis in the elderly: new issues for an old disease. ( 27621607 )
2016
18
Morbidity and mortality of infective endocarditis in a hospital system in New York City serving a diverse urban population. ( 27206447 )
2016
19
What's new in surgical treatment of infective endocarditis? ( 27663580 )
2016
20
Ruptured Sinus of Valsalva with Infective Endocarditis Complicated with Post-Infectious Acute Glomerulonephritis: A Rare Case Presentation. ( 27891383 )
2016
21
Infective Endocarditis With Paravalvular Extension: 35-Year Experience. ( 27207394 )
2016
22
Infective endocarditis as a rare cause for acute limb ischemia. ( 27547285 )
2016
23
Use of Dithiothreitol to Dislodge Bacteria From the Biofilm on an Aortic Valve in the Operating Theatre: A Case of Infective Endocarditis Caused by Staphylococcus aureus and Proteus mirabilis. ( 27645982 )
2016
24
Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis. ( 27871078 )
2016
25
Infective endocarditis of an aorto-right atrial fistula caused by asymptomatic rupture of a sinus of Valsalva aneurysm: a case report. ( 27180251 )
2016
26
Right-sided Infective Endocarditis in an Indian Intensive Care Unit. ( 27621564 )
2016
27
Ventricular Septal Defect from Aortic Regurgitation Jet Lesion in Aortic Valve Infective Endocarditis. ( 27989057 )
2016
28
Large vegetation secondary to native mitral valve infective endocarditis in child. ( 27130493 )
2016
29
Intermittent High-Grade Atrioventricular Block in a Man With Infective Endocarditis. ( 27087175 )
2016
30
Does type of prosthesis affect long-term outcomes after aortic valve replacement for infective endocarditis? How should we properly answer this question? ( 27993368 )
2016
31
Reconstruction of a Previously Repaired Aortic Valve Destroyed by Infective Endocarditis: Case Report. ( 27162188 )
2016
32
The Effect of Antibiotic Prophylaxis Guidelines on Incidence of Infective Endocarditis. ( 27160964 )
2016
33
Time Interval between Infective Endocarditis First Symptoms and Diagnosis: Relationship to Infective Endocarditis characteristics, Microorganisms and Prognosis. ( 27607562 )
2016
34
Long-Term Outcome and Valve Surgery for Infective Endocarditis in the Systematic Analysis of a Community Study. ( 27131900 )
2016
35
Not So EASE-Y: How Often do Hospitalized Infective Endocarditis Patients Meet Criteria for Early Surgery? ( 27989088 )
2016
36
MULTIPLE DRUGS CAUSING SEVERE ANEMIA IN INFECTIVE ENDOCARDITIS. ( 27215287 )
2016
37
Infective endocarditis. ( 27580514 )
2016
38
Emergency cardiac double valve surgery in active infective endocarditis due to Acinetobacter baumannii with aortic root abscess in a patient with dialysis-dependent end-stage renal failure: a rare case report. ( 27915239 )
2016
39
Draft Genome Sequence of a Cardiobacterium hominis Strain Isolated from Blood Cultures of a Patient with Infective Endocarditis. ( 27660783 )
2016
40
Coronary Sinus Ostial Atresia Presenting as Infective Endocarditis in a Previously Healthy Young Woman. ( 28054906 )
2016
41
Alternative Cardiac Imaging Modalities to Echocardiography for the Diagnosis of Infective Endocarditis. ( 27600463 )
2016
42
Infective endocarditis. ( 27582414 )
2016
43
Three-dimensional compared to two-dimensional transesophageal echocardiography for diagnosis of infective endocarditis. ( 27189337 )
2016
44
Atrial septal defect infective endocarditis: a direct pathway from left atrium to the lung. ( 27165630 )
2016
45
Infective Endocarditis After Device Closure of Atrial Septal Defects: Case Report and Review of the Literature. ( 27641431 )
2016
46
A review of the role of anticoagulation for patients with infective endocarditis and embolic stroke. ( 27190618 )
2016
47
Prognostic factors in infective endocarditis in general hospitals in the Netherlands. ( 27189213 )
2016
48
Is brain angio-MRI useful in infective endocarditis management? ( 27599711 )
2016
49
Superior Vena Cava Syndrome with Cardiac Device-related Infective Endocarditis Secondary to Pacemaker Infection. ( 26899510 )
2016
50
Transplantation in a patient on extracorporeal membrane oxygenation with infective endocarditis, pericarditis and heparin-induced thrombocytopenia. ( 28040771 )
2016

Variations for Infective Endocarditis

Expression for Infective Endocarditis

Search GEO for disease gene expression data for Infective Endocarditis.

Pathways for Infective Endocarditis

Pathways related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.86 IL6 SERPINE1 TLR2 TLR6 TNF
2
Show member pathways
12.73 IL6 LBP SERPINE1 TLR2 TLR6 TNF
3
Show member pathways
12.57 IL6 TLR2 TLR6 TNF
4
Show member pathways
12.5 ITGB3 LBP TLR2 TLR6 TNF
5
Show member pathways
12.14 IL6 TLR2 TLR6 TNF
6
Show member pathways
12.06 IL6 ITGB3 TNF TNNI3
7
Show member pathways
12.05 CRP F2 IL6 SERPINE1 TNF
8 12.03 IL6 TLR2 TLR6 TNF
9 11.98 FCGR2A ITGB3 TLR2 TLR6
10 11.96 SERPINE1 TLR2 TLR6
11 11.94 IL6 SERPINE1 TNF
12 11.93 FCGR2A ITGB3 TNF
13 11.9 FCGR2A GP1BA ITGB3
14 11.89 FCGR2A IL6 TNF
15 11.86 IL6 LBP TNF
16
Show member pathways
11.8 IL6 TLR2 TLR6
17
Show member pathways
11.79 IL6 TLR2 TLR6 TNF
18 11.78 IL6 SERPINE1 TNF
19
Show member pathways
11.77 F2 GP1BA ITGB3
20
Show member pathways
11.77 IL6 LBP TLR2 TLR6 TNF
21 11.76 IL6 TLR2 TNF
22 11.72 IL6 TLR2 TNF
23 11.72 GP1BA IL6 ITGB3 TNF
24
Show member pathways
11.69 CRP IL6 LBP
25 11.6 FCGR2A ITGB3 TLR2 TLR6
26 11.49 IL6 TLR2 TNF
27 11.42 FCGR2A GP1BA IL6 ITGB3 TNF
28 11.41 IL6 TLR2 TNF
29 11.4 FCGR2A IL6 TLR2 TNF
30 11.39 GP1BA IL6 TNF
31 11.35 FCGR2A IL6 LBP TLR2 TLR6 TNF
32 11 IL6 TNF
33 10.86 CRP IL6 TNF

GO Terms for Infective Endocarditis

Cellular components related to Infective Endocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 APOH CRP F2 FCGR2A GP1BA ITGB3
2 extracellular space GO:0005615 9.5 APOH CRP F2 IL6 LBP SERPINE1
3 cell surface GO:0009986 9.1 APOH GP1BA ITGB3 LBP TLR2 TNF

Biological processes related to Infective Endocarditis according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 CRP IL6 TLR2 TLR6 TNF
2 positive regulation of gene expression GO:0010628 9.95 CRP IL6 TLR2 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 IL6 TLR2 TNF
4 platelet degranulation GO:0002576 9.83 APOH ITGB3 SERPINE1
5 cellular response to lipopolysaccharide GO:0071222 9.83 IL6 LBP SERPINE1 TNF
6 platelet activation GO:0030168 9.81 F2 GP1BA IL6 ITGB3
7 defense response to Gram-negative bacterium GO:0050829 9.78 IL6 LBP SERPINE1
8 toll-like receptor signaling pathway GO:0002224 9.76 LBP TLR2 TLR6
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 LBP TLR2 TNF
10 positive regulation of NF-kappaB import into nucleus GO:0042346 9.67 TLR2 TNF
11 regulation of blood coagulation GO:0030193 9.67 APOH F2 GP1BA
12 positive regulation of interleukin-6 production GO:0032755 9.67 IL6 LBP TLR2 TNF
13 negative regulation of growth of symbiont in host GO:0044130 9.65 LBP TNF
14 cell activation GO:0001775 9.65 TLR2 TLR6
15 fibrinolysis GO:0042730 9.65 F2 GP1BA SERPINE1
16 microglial cell activation GO:0001774 9.64 TLR2 TLR6
17 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.64 CRP ITGB3
18 negative regulation of blood coagulation GO:0030195 9.63 APOH SERPINE1
19 regulation of cytokine secretion GO:0050707 9.63 TLR2 TLR6
20 blood coagulation, intrinsic pathway GO:0007597 9.63 APOH F2 GP1BA
21 opsonization GO:0008228 9.62 CRP LBP
22 cellular response to lipoteichoic acid GO:0071223 9.62 LBP TLR2
23 acute-phase response GO:0006953 9.62 CRP F2 IL6 LBP
24 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
25 positive regulation of blood coagulation GO:0030194 9.61 APOH F2 SERPINE1
26 cellular response to diacyl bacterial lipopeptide GO:0071726 9.6 TLR2 TLR6
27 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.59 TLR2 TLR6
28 negative regulation of fibrinolysis GO:0051918 9.58 APOH F2 SERPINE1
29 nitric oxide metabolic process GO:0046209 9.57 TLR2 TLR6
30 positive regulation of interleukin-8 production GO:0032757 9.56 LBP SERPINE1 TLR2 TNF
31 detection of diacyl bacterial lipopeptide GO:0042496 9.55 TLR2 TLR6
32 defense response to Gram-positive bacterium GO:0050830 9.55 CRP IL6 LBP TLR2 TNF
33 response to bacterial lipoprotein GO:0032493 9.54 TLR2 TLR6
34 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
35 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 ITGB3 TNF

Molecular functions related to Infective Endocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 APOH CRP F2 FCGR2A GP1BA IL6
2 receptor binding GO:0005102 9.62 F2 IL6 LBP SERPINE1
3 protease binding GO:0002020 9.43 ITGB3 SERPINE1 TNF
4 lipopolysaccharide binding GO:0001530 9.13 F2 LBP TLR2
5 lipopeptide binding GO:0071723 8.8 LBP TLR2 TLR6

Sources for Infective Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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