MCID: INF133
MIFTS: 27

Inferior Vena Cava Interruption malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Inferior Vena Cava Interruption

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MalaCards: Inferior Vena Cava Interruption, also known as inferior caval vein interruption, is related to pulmonary embolism and dextrocardia. An important gene associated with Inferior Vena Cava Interruption is SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), and among its related pathways are Platelet degranulation and Complement and coagulation cascades. The compounds heparin and batroxobin have been mentioned in the context of this disorder. Related mouse phenotype integument.

Aliases & Classifications for Inferior Vena Cava Interruption

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48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

inferior vena cava interruption 48
inferior caval vein interruption 48
ivc interruption 48


External Ids:

ICD10 via Orphanet26 Q26.8

Related Diseases for Inferior Vena Cava Interruption

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17GeneCards, 18GeneDecks
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Diseases related to Inferior Vena Cava Interruption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism30.9MTHFR, F5
2dextrocardia10.3
3branch retinal artery occlusion10.0F5
4retinal vascular occlusion10.0F5
5purpura fulminans10.0F5
6thrombocytopenia10.0F5
7meningococcemia10.0F5
8patent foramen ovale10.0F5
9ovarian hyperstimulation syndrome10.0F5
10galactosemia10.0F5
11coronary thrombosis10.0SERPINE1
12polycystic ovary syndrome10.0SERPINE1
13acute myocardial infarction10.0SERPINE1
14essential hypertension10.0SERPINE1
15hemorrhagic disease10.0SERPINE1
16insulin resistance10.0SERPINE1
17cerebrovascular disease10.0MTHFR
18lupus erythematosus10.0F5
19migraine10.0MTHFR
20eclampsia10.0MTHFR
21obesity10.0SERPINE1
22neural tube defects10.0MTHFR
23severe pre-eclampsia10.0SERPINE1, F5
24rheumatoid arthritis10.0MTHFR
25disseminated intravascular coagulation10.0SERPINE1, F5
26septic shock10.0SERPINE1, F5
27central retinal vein occlusion10.0MTHFR, F5
28portal vein thrombosis10.0F5, MTHFR
29retinal vein occlusion10.0F5, MTHFR
30antiphospholipid syndrome10.0MTHFR, F5
31hepatic vein thrombosis10.0MTHFR, F5
32blood protein disease10.0F5, MTHFR
33intracranial thrombosis10.0MTHFR, F5
34antithrombin iii deficiency10.0F5, MTHFR
35homocysteinemia10.0F5, MTHFR
36pregnancy loss10.0MTHFR, F5
37homocystinuria10.0MTHFR, F5
38placental abruption10.0MTHFR, F5
39coronary heart disease10.0SERPINE1, MTHFR
40colon cancer10.0MTHFR
41arteriosclerosis10.0MTHFR, SERPINE1
42congenital heart defect10.0SERPINE1, MTHFR
43diabetes mellitus10.0SERPINE1, MTHFR
44atherosclerosis10.0MTHFR, SERPINE1
45factor v leiden thrombophilia10.0SERPINE1, F5
46diabetic nephropathy10.0SERPINE1, MTHFR
47coronary artery disease10.0SERPINE1, MTHFR
48protein c deficiency10.0SERPINE1, MTHFR, F5
49venous thrombosis10.0SERPINE1, MTHFR, F5
50hellp syndrome10.0F5, MTHFR, SERPINE1

Graphical network of the top 20 diseases related to Inferior Vena Cava Interruption:



Diseases related to inferior vena cava interruption

Clinical Features for Inferior Vena Cava Interruption

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Drugs & Therapeutics for Inferior Vena Cava Interruption

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Inferior Vena Cava Interruption

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Anatomical Context for Inferior Vena Cava Interruption

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Animal Models for Inferior Vena Cava Interruption or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Inferior Vena Cava Interruption:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5SERPINE1, MTHFR, F5

Publications for Inferior Vena Cava Interruption

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Genetic Variations for Inferior Vena Cava Interruption

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Expression for genes affiliated with Inferior Vena Cava Interruption

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inferior Vena Cava Interruption

Search GEO for disease gene expression data for Inferior Vena Cava Interruption.

Pathways for genes affiliated with Inferior Vena Cava Interruption

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.3SERPINE1, F5
2
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9.3SERPINE1, F5
3
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9.3SERPINE1, F5
49.0SERPINE1, MTHFR

Compounds for genes affiliated with Inferior Vena Cava Interruption

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2413.0MTHFR
2batroxobin449.7F5, SERPINE1
3ancrod449.7SERPINE1, F5
4Drotrecogin alfa119.7F5, SERPINE1
5tibolone449.7SERPINE1, F5
6cyproteroneacetate449.7SERPINE1, F5
7desmopressin44 59 28 1112.7SERPINE1, F5
8hirudin449.7F5, SERPINE1
9mycophenolate mofetil44 49 1111.7SERPINE1, F5
10protamine449.7F5, SERPINE1
11raloxifene44 28 49 1112.7SERPINE1, F5
12kininogen449.6F5, SERPINE1
13pge1449.6F5, SERPINE1
14aprotinin44 1110.6F5, SERPINE1
15progestin449.6F5, SERPINE1
16sodium dodecylsulfate449.6F5, SERPINE1
175-methyltetrahydrofolate44 1110.5MTHFR, F5
18atorvastatin44 49 28 11 2413.5F5, SERPINE1
19cystathionine449.5F5, MTHFR
20vitamin b6449.5F5, MTHFR
21simvastatin44 49 59 28 11 2414.4F5, SERPINE1
22vitamin b12449.4MTHFR, F5
23p00001449.4SERPINE1, MTHFR
24endotoxin449.4F5, SERPINE1
25p002449.3MTHFR, F5
26adenine44 11 2411.3F5, MTHFR
27prostacyclin449.2SERPINE1, F5
28folate449.1MTHFR, F5
29methotrexate44 49 1111.0MTHFR, SERPINE1
30metformin44 49 1110.9SERPINE1, MTHFR, F5
31uric acid44 249.9F5, SERPINE1, MTHFR
32homocysteine44 249.9F5, MTHFR, SERPINE1
33cyclophosphamide44 49 1110.9SERPINE1, F5, MTHFR
34aspirin44 49 28 2411.9SERPINE1, MTHFR, F5
35fibrinogen448.9SERPINE1, F5, MTHFR
36creatinine448.9F5, SERPINE1, MTHFR
37testosterone44 59 11 2411.9SERPINE1, F5, MTHFR
38cholesterol44 28 11 2411.8F5, SERPINE1, MTHFR
39guanine44 11 2410.8MTHFR, F5
40estrogen448.8SERPINE1, F5, MTHFR
41retinoic acid44 249.7MTHFR, SERPINE1, F5

GO Terms for genes affiliated with Inferior Vena Cava Interruption

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16Gene Ontology
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Cellular components related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3SERPINE1, F5

Biological processes related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.3SERPINE1, F5
2platelet degranulationGO:0025769.0SERPINE1, F5
3blood circulationGO:0080159.0MTHFR, F5

Products for genes affiliated with Inferior Vena Cava Interruption

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inferior Vena Cava Interruption

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet