MCID: INF133
MIFTS: 35

Inferior Vena Cava Interruption malady

Cardiovascular diseases, Fetal diseases, Rare diseases categories

Summaries for Inferior Vena Cava Interruption

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34MalaCards
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MalaCards: Inferior Vena Cava Interruption, also known as inferior caval vein interruption, is related to pulmonary embolism and dextrocardia. An important gene associated with Inferior Vena Cava Interruption is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. The compounds batroxobin and ancrod have been mentioned in the context of this disorder. Affiliated tissues include liver and lung, and related mouse phenotype integument.

Aliases & Classifications for Inferior Vena Cava Interruption

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50Orphanet, 27ICD10 via Orphanet
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Related Diseases for Inferior Vena Cava Interruption

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18GeneCards, 19GeneDecks
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Diseases related to Inferior Vena Cava Interruption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism31.0F5, MTHFR
2dextrocardia10.4
3double inferior vena cava10.4
4coronary thrombosis10.1SERPINE1
5branch retinal artery occlusion10.1F5
6purpura fulminans10.1F5
7meningococcemia10.1F5
8eclampsia10.1MTHFR
9severe pre-eclampsia10.0F5, SERPINE1
10disseminated intravascular coagulation10.0F5, SERPINE1
11septic shock10.0F5, SERPINE1
12central retinal vein occlusion10.0F5, MTHFR
13factor v leiden thrombophilia10.0F5, SERPINE1
14hepatic vein thrombosis10.0MTHFR, F5
15retinal vein occlusion10.0F5, MTHFR
16blood protein disease10.0F5, MTHFR
17portal vein thrombosis10.0MTHFR, F5
18antithrombin iii deficiency10.0MTHFR, F5
19intracranial thrombosis10.0MTHFR, F5
20homocysteinemia10.0F5, MTHFR
21arteriosclerosis10.0MTHFR, SERPINE1
22placental abruption10.0F5, MTHFR
23congenital heart disease10.0MTHFR, SERPINE1
24sepsis10.0F5, SERPINE1
25homocystinuria10.0MTHFR, F5
26pregnancy loss10.0F5, MTHFR
27diabetic nephropathy10.0SERPINE1, MTHFR
28antiphospholipid syndrome10.0F5, MTHFR
29coronary artery disease10.0SERPINE1, MTHFR
30diabetes mellitus10.0MTHFR, SERPINE1
31type 2 diabetes mellitus10.0SERPINE1, MTHFR
32protein s deficiency10.0F5, MTHFR, SERPINE1
33hellp syndrome10.0SERPINE1, MTHFR, F5
34protein c deficiency9.9SERPINE1, MTHFR, F5
35thrombophilia9.9F5, MTHFR, SERPINE1
36thromboembolism9.9SERPINE1, MTHFR, F5
37venous thrombosis9.9F5, MTHFR, SERPINE1
38hyperhomocysteinemia9.9F5, MTHFR, SERPINE1
39stroke, ischemic9.9F5, MTHFR, SERPINE1
40hypertension9.9SERPINE1, MTHFR, F5
41vascular disease9.9F5, MTHFR, SERPINE1
42pre-eclampsia9.9SERPINE1, MTHFR, F5
43cerebrovascular disease9.9SERPINE1, MTHFR, F5
44myocardial infarction9.9SERPINE1, MTHFR, F5
45primary hyperoxaluria9.9MTHFR, SERPINE1

Graphical network of the top 20 diseases related to Inferior Vena Cava Interruption:



Diseases related to inferior vena cava interruption

Symptoms for Inferior Vena Cava Interruption

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Drugs & Therapeutics for Inferior Vena Cava Interruption

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Genetic Tests for Inferior Vena Cava Interruption

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Anatomical Context for Inferior Vena Cava Interruption

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34MalaCards
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MalaCards organs/tissues related to Inferior Vena Cava Interruption:

34
Liver, Lung

Animal Models for Inferior Vena Cava Interruption or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Inferior Vena Cava Interruption:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5F5, MTHFR, SERPINE1

Publications for Inferior Vena Cava Interruption

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53PubMed
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Articles related to Inferior Vena Cava Interruption:

(show all 20)
idTitleAuthorsYear
1
Transapical closure of paraprosthetic mitral leak in a patient with inferior vena cava interruption and azygos continuation. (24048023)
2013
2
Inferior vena cava interruption in a liver transplantation deceased donor. (23230844)
2013
3
Atrial flutter ablation through the azygous continuation in a patient with inferior vena cava interruption. (21030393)
2011
4
Deep vein thrombosis, inferior vena cava interruption and multiple thrombophilic gene mutations. (21642818)
2011
5
Infrahepatic caudal/inferior vena cava interruption with azygos/hemiazygos continuation. Vascular anomaly in swine. (22933907)
2010
6
Pulmonary embolism associated with inferior vena cava interruption: multidetector computed tomography findings. (20498625)
2010
7
Radiofrequency ablation of atrioventricular nodal tachycardia in a patient with dextrocardia, inferior vena cava interruption, and azygos continuation. (18031517)
2008
8
Catheter ablation of left free wall accessory pathway in a patient with inferior vena cava interruption. (12674185)
2002
9
Inferior vena cava interruption: how and when? (10774449)
2000
10
Inferior vena cava interruption with renal vein collar continuation: CT and MRI appearance. (1773417)
1991
11
The Vena Tech filter: evaluation of a new inferior vena cava interruption device. (1939334)
1991
12
Inferior vena cava interruption with the Hunter-Sessions balloon: eighteen years' experience in 191 cases. (2795770)
1989
13
Transvenous devices for inferior vena cava interruption. (2585660)
1989
14
Recurrent, fatal pulmonary embolism despite inferior vena cava interruption with the Greenfield filter. (3577368)
1987
15
Inferior vena cava interruption. (3874355)
1985
16
Inferior vena cava interruption in the management of pulmonary embolism. (7140404)
1982
17
Requirements for a method of transvenous inferior vena cava interruption. (7436725)
1980
18
Diagnosis of pulmonary embolism: correlation of value of perfusion lung scan and pulmonary arteriography in selecting patients for inferior vena cava interruption. (637417)
1978
19
Inferior vena cava interruption: a new indication? (1164184)
1975
20
Fatal complications following inferior vena cava interruption. (5159420)
1971

Variations for Inferior Vena Cava Interruption

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Expression for genes affiliated with Inferior Vena Cava Interruption

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inferior Vena Cava Interruption

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Pathways for genes affiliated with Inferior Vena Cava Interruption

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51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems
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Pathways related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3F5, SERPINE1
2
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.3F5, SERPINE1
3
Show member pathways
9.3F5, SERPINE1
4
Show member pathways
thioredoxin pathway39
9.1MTHFR, SERPINE1

Compounds for genes affiliated with Inferior Vena Cava Interruption

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46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1batroxobin469.8SERPINE1, F5
2ancrod469.8F5, SERPINE1
3tibolone469.7SERPINE1, F5
4cyproteroneacetate469.7F5, SERPINE1
5desmopressin46 62 30 1212.7F5, SERPINE1
6hirudin469.7F5, SERPINE1
7protamine469.7SERPINE1, F5
8mycophenolate mofetil46 52 1211.7F5, SERPINE1
9raloxifene46 52 30 1212.7F5, SERPINE1
10kininogen469.7SERPINE1, F5
11pge1469.7F5, SERPINE1
12aprotinin46 1210.6F5, SERPINE1
13progestin469.6SERPINE1, F5
14sodium dodecylsulfate469.6F5, SERPINE1
15atorvastatin46 52 30 25 1213.6F5, SERPINE1
16simvastatin46 52 62 30 25 1214.6F5, SERPINE1
17endotoxin469.5SERPINE1, F5
18p00001469.5SERPINE1, MTHFR
19prostacyclin469.5F5, SERPINE1
205-methyltetrahydrofolate46 1210.5MTHFR, F5
21cystathionine469.5F5, MTHFR
22pravastatin46 52 30 25 1213.4MTHFR, SERPINE1
23vitamin b6469.4F5, MTHFR
24tacrolimus46 52 1211.4F5, SERPINE1
25warfarin46 52 25 1212.4F5, MTHFR
26vitamin b12469.4F5, MTHFR
27p002469.3MTHFR, F5
28adenine46 25 1211.3F5, MTHFR
29folate469.2F5, MTHFR
30vitamin d469.1MTHFR, SERPINE1
31guanine46 25 1211.0F5, MTHFR
32methotrexate52 46 1211.0SERPINE1, MTHFR
33metformin46 52 1211.0F5, MTHFR, SERPINE1
34uric acid46 2510.0F5, MTHFR, SERPINE1
35homocysteine46 259.9SERPINE1, MTHFR, F5
36cyclophosphamide46 52 1210.9F5, MTHFR, SERPINE1
37aspirin46 52 30 2511.9F5, MTHFR, SERPINE1
38fibrinogen468.9F5, MTHFR, SERPINE1
39creatinine468.9F5, MTHFR, SERPINE1
40aspartate468.9SERPINE1, MTHFR, F5
41heparin46 30 25 1211.9F5, MTHFR, SERPINE1
42testosterone46 62 25 1211.9SERPINE1, MTHFR, F5
43cholesterol46 30 25 1211.9F5, MTHFR, SERPINE1
44estrogen468.8F5, MTHFR, SERPINE1
45retinoic acid46 259.8SERPINE1, MTHFR, F5
46ascorbic acid46 259.7F5, MTHFR
47serine468.6SERPINE1, MTHFR, F5

GO Terms for genes affiliated with Inferior Vena Cava Interruption

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17Gene Ontology
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Cellular components related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3F5, SERPINE1

Biological processes related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.3F5, SERPINE1
2platelet degranulationGO:0025769.0F5, SERPINE1
3blood circulationGO:0080158.9F5, MTHFR

Products for genes affiliated with Inferior Vena Cava Interruption

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Sources for Inferior Vena Cava Interruption

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet