MCID: INF133
MIFTS: 35

Inferior Vena Cava Interruption malady

Cardiovascular diseases, Fetal diseases, Rare diseases categories

Summaries for Inferior Vena Cava Interruption

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MalaCards based summary: Inferior Vena Cava Interruption, also known as inferior caval vein interruption, is related to pulmonary embolism and dextrocardia. An important gene associated with Inferior Vena Cava Interruption is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. The compounds batroxobin and ancrod have been mentioned in the context of this disorder. Affiliated tissues include liver and lung, and related mouse phenotype integument.

Aliases & Classifications for Inferior Vena Cava Interruption

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Sources:
49Orphanet, 28ICD10 via Orphanet
See all sources

Inferior Vena Cava Interruption, Aliases & Descriptions:

Name: Inferior Vena Cava Interruption 49
Inferior Caval Vein Interruption 49
 
Ivc Interruption 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Orphanet49 99123
ICD10 via Orphanet28 Q26.8

Related Diseases for Inferior Vena Cava Interruption

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Diseases related to Inferior Vena Cava Interruption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary embolism31.0F5, MTHFR
2dextrocardia10.4
3double inferior vena cava10.4
4coronary thrombosis10.0SERPINE1
5branch retinal artery occlusion10.0F5
6meningococcemia10.0F5
7eclampsia10.0MTHFR
8severe pre-eclampsia10.0F5, SERPINE1
9disseminated intravascular coagulation10.0SERPINE1, F5
10central retinal vein occlusion10.0MTHFR, F5
11nonarteritic anterior ischemic optic neuropathy10.0MTHFR, F5
12budd-chiari syndrome10.0F5, MTHFR
13retinal vein occlusion10.0F5, MTHFR
14blood protein disease10.0F5, MTHFR
15factor v leiden thrombophilia10.0F5, SERPINE1
16thrombophilia due to antithrombin iii deficiency10.0MTHFR, F5
17intracranial thrombosis10.0MTHFR, F5
18portal vein thrombosis10.0MTHFR, F5
19homocysteinemia10.0F5, MTHFR
20arteriosclerosis10.0MTHFR, SERPINE1
21placental abruption10.0MTHFR, F5
22congenital heart disease10.0SERPINE1, MTHFR
23homocystinuria10.0MTHFR, F5
24pregnancy loss, recurrent 110.0MTHFR, F5
25microvascular complications of diabetes 310.0SERPINE1, MTHFR
26antiphospholipid syndrome10.0F5, MTHFR
27coronary artery disease10.0SERPINE1, MTHFR
28diabetes mellitus, insulin-dependent10.0SERPINE1, MTHFR
29diabetes mellitus, noninsulin-dependent10.0SERPINE1, MTHFR
30protein s deficiency10.0F5, MTHFR, SERPINE1
31hellp syndrome10.0SERPINE1, MTHFR, F5
32thrombophilia due to activated protein c resistance10.0SERPINE1, MTHFR, F5
33protein c deficiency10.0MTHFR, F5, SERPINE1
34thrombophilia10.0F5, MTHFR, SERPINE1
35hyperhomocysteinemia10.0F5, SERPINE1, MTHFR
36thrombophilia due to thrombin defect10.0F5, MTHFR, SERPINE1
37hypertension, essential10.0MTHFR, SERPINE1, F5
38vascular disease10.0SERPINE1, MTHFR, F5
39preeclampsia/eclampsia 110.0F5, MTHFR, SERPINE1
40stroke, ischemic10.0F5, MTHFR, SERPINE1
41primary hyperoxaluria10.0SERPINE1, MTHFR
42myocardial infarction10.0MTHFR, SERPINE1, F5

Graphical network of the top 20 diseases related to Inferior Vena Cava Interruption:



Diseases related to inferior vena cava interruption

Symptoms for Inferior Vena Cava Interruption

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Drugs & Therapeutics for Inferior Vena Cava Interruption

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Drug clinical trials:

Search ClinicalTrials for Inferior Vena Cava Interruption

Search NIH Clinical Center for Inferior Vena Cava Interruption

Genetic Tests for Inferior Vena Cava Interruption

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Anatomical Context for Inferior Vena Cava Interruption

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MalaCards organs/tissues related to Inferior Vena Cava Interruption:

33
Liver, Lung

Animal Models for Inferior Vena Cava Interruption or affiliated genes

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MGI Mouse Phenotypes related to Inferior Vena Cava Interruption:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5F5, MTHFR, SERPINE1

Publications for Inferior Vena Cava Interruption

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Articles related to Inferior Vena Cava Interruption:

(show all 20)
idTitleAuthorsYear
1
Transapical closure of paraprosthetic mitral leak in a patient with inferior vena cava interruption and azygos continuation. (24048023)
2013
2
Inferior vena cava interruption in a liver transplantation deceased donor. (23230844)
2013
3
Atrial flutter ablation through the azygous continuation in a patient with inferior vena cava interruption. (21030393)
2011
4
Deep vein thrombosis, inferior vena cava interruption and multiple thrombophilic gene mutations. (21642818)
2011
5
Infrahepatic caudal/inferior vena cava interruption with azygos/hemiazygos continuation. Vascular anomaly in swine. (22933907)
2010
6
Pulmonary embolism associated with inferior vena cava interruption: multidetector computed tomography findings. (20498625)
2010
7
Radiofrequency ablation of atrioventricular nodal tachycardia in a patient with dextrocardia, inferior vena cava interruption, and azygos continuation. (18031517)
2008
8
Catheter ablation of left free wall accessory pathway in a patient with inferior vena cava interruption. (12674185)
2002
9
Inferior vena cava interruption: how and when? (10774449)
2000
10
Inferior vena cava interruption with renal vein collar continuation: CT and MRI appearance. (1773417)
1991
11
The Vena Tech filter: evaluation of a new inferior vena cava interruption device. (1939334)
1991
12
Inferior vena cava interruption with the Hunter-Sessions balloon: eighteen years' experience in 191 cases. (2795770)
1989
13
Transvenous devices for inferior vena cava interruption. (2585660)
1989
14
Recurrent, fatal pulmonary embolism despite inferior vena cava interruption with the Greenfield filter. (3577368)
1987
15
Inferior vena cava interruption. (3874355)
1985
16
Inferior vena cava interruption in the management of pulmonary embolism. (7140404)
1982
17
Requirements for a method of transvenous inferior vena cava interruption. (7436725)
1980
18
Diagnosis of pulmonary embolism: correlation of value of perfusion lung scan and pulmonary arteriography in selecting patients for inferior vena cava interruption. (637417)
1978
19
Inferior vena cava interruption: a new indication? (1164184)
1975
20
Fatal complications following inferior vena cava interruption. (5159420)
1971

Variations for Inferior Vena Cava Interruption

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Expression for genes affiliated with Inferior Vena Cava Interruption

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Search GEO for disease gene expression data for Inferior Vena Cava Interruption.

Pathways for genes affiliated with Inferior Vena Cava Interruption

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Pathways related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3F5, SERPINE1
2
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.3F5, SERPINE1
3
Show member pathways
9.3F5, SERPINE1
4
Show member pathways
thioredoxin pathway38
9.1MTHFR, SERPINE1

Compounds for genes affiliated with Inferior Vena Cava Interruption

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Compounds related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1batroxobin459.8SERPINE1, F5
2ancrod459.8F5, SERPINE1
3tibolone459.7SERPINE1, F5
4cyproteroneacetate459.7F5, SERPINE1
5desmopressin45 61 30 1312.7F5, SERPINE1
6hirudin459.7F5, SERPINE1
7protamine459.7SERPINE1, F5
8mycophenolate mofetil45 51 1311.7F5, SERPINE1
9raloxifene45 51 30 1312.7F5, SERPINE1
10kininogen459.7SERPINE1, F5
11pge1459.7F5, SERPINE1
12aprotinin45 1310.6F5, SERPINE1
13progestin459.6SERPINE1, F5
14sodium dodecylsulfate459.6F5, SERPINE1
15atorvastatin45 51 30 26 1313.6F5, SERPINE1
16simvastatin45 51 61 30 26 1314.6F5, SERPINE1
17endotoxin459.5SERPINE1, F5
18p00001459.5SERPINE1, MTHFR
19prostacyclin459.5F5, SERPINE1
205-methyltetrahydrofolate45 1310.5MTHFR, F5
21cystathionine459.5F5, MTHFR
22pravastatin45 51 30 26 1313.4MTHFR, SERPINE1
23vitamin b6459.4F5, MTHFR
24tacrolimus45 51 1311.4F5, SERPINE1
25warfarin45 51 26 1312.4F5, MTHFR
26vitamin b12459.4F5, MTHFR
27p002459.3MTHFR, F5
28adenine45 26 1311.3F5, MTHFR
29folate459.2F5, MTHFR
30vitamin d459.1MTHFR, SERPINE1
31guanine45 26 1311.0F5, MTHFR
32methotrexate51 45 1311.0SERPINE1, MTHFR
33metformin45 51 1311.0F5, MTHFR, SERPINE1
34uric acid45 2610.0F5, MTHFR, SERPINE1
35homocysteine45 269.9SERPINE1, MTHFR, F5
36cyclophosphamide45 51 1310.9F5, MTHFR, SERPINE1
37aspirin45 51 30 2611.9F5, MTHFR, SERPINE1
38fibrinogen458.9F5, MTHFR, SERPINE1
39creatinine458.9F5, MTHFR, SERPINE1
40aspartate458.9SERPINE1, MTHFR, F5
41heparin45 30 26 1311.9F5, MTHFR, SERPINE1
42testosterone45 61 26 1311.9SERPINE1, MTHFR, F5
43cholesterol45 30 26 1311.9F5, MTHFR, SERPINE1
44estrogen458.8F5, MTHFR, SERPINE1
45retinoic acid45 269.8SERPINE1, MTHFR, F5
46ascorbic acid45 269.7F5, MTHFR
47serine458.6SERPINE1, MTHFR, F5

GO Terms for genes affiliated with Inferior Vena Cava Interruption

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Cellular components related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.3F5, SERPINE1

Biological processes related to Inferior Vena Cava Interruption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:00301689.3F5, SERPINE1
2platelet degranulationGO:00025769.0F5, SERPINE1
3blood circulationGO:00080158.9F5, MTHFR

Products for genes affiliated with Inferior Vena Cava Interruption

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  • Antibodies
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Sources for Inferior Vena Cava Interruption

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet