MCID: INF032
MIFTS: 56

Infertility malady

Summaries for Infertility

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Infertility means not being able to become pregnant after a year of trying. if a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. infertility is fairly common. after one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. about a third of the time, infertility can be traced to the woman. in another third of cases, it is because of the man. the rest of the time, it is because of both partners or no cause can be found. there are treatments that are specifically for men or for women. some involve both partners. drugs or surgery are common treatments. happily, many couples treated for infertility go on to have babies. nih: national institute of child health and human development

MalaCards: Infertility is related to male infertility and azoospermia. An important gene associated with Infertility is DDX3Y (DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked). The drugs bromocriptine and follitropin beta have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis.

CDC:3 In general, infertility is defined as not being able to get pregnant (conceive) after one year of unprotected sex. Women who do not have regular menstrual cycles, or are older than 35 years and have not conceived during a 6-month period of trying, should consider making an appointment with a reproductive endocrinologist—an infertility specialist. These doctors may also be able to help women with recurrent pregnancy loss—2 or more spontaneous miscarriages. Pregnancy is the result of a process that has many steps. To get pregnant—

Wikipedia:63 Infertility is fundamentally the inability to conceive offspring. Infertility also refers to the state... more...

Aliases & Classifications for Infertility

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Sources:
8Disease Ontology, 63Wikipedia, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

infertility 8 63 22 10 44 33 60


External Ids:

Disease Ontology8 DOID:5223
MeSH34 D007246
NCIt39 C3836

Related Diseases for Infertility

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1male infertility31.8DDX3Y, DAZL, USP26
2azoospermia31.0USP26, DDX3Y, DAZAP1, H2BFWT, DAZL
3y chromosome infertility30.6DDX3Y, HSFY1
4oligospermia30.6DDX3Y, DAZL
5sertoli cell-only syndrome30.2DDX3Y
6endometriosis10.8
7varicocele10.8
8polycystic ovary syndrome10.5
9cryptorchidism10.4
10anovulation10.4
11hypogonadism10.4
12salpingitis10.4
13obesity10.4
14peritonitis10.4
15hyperprolactinemia10.4
16thyroiditis10.4
17deafness-infertility syndrome10.4
18prostatitis10.4
19cystic fibrosis10.3
20cervicitis10.3
21pelvic inflammatory disease10.3
22leukemia10.3
23endometritis10.3
24catsper1-related nonsyndromic male infertility10.2
25congenital adrenal hyperplasia10.2
26hypogonadotropism10.2
27vaginitis10.2
2821-hydroxylase deficiency10.2
29klinefelter's syndrome10.2
30hyperandrogenism10.2
31hypothyroidism10.2
32testicular cancer10.2
33congenital absence of the vas deferens10.2
34spermatogenic failure 410.2
35female infertility of uterine origin10.2
36impotence10.2
37thrombophilia10.2
38amenorrhea10.1
39orchitis10.1
40catsper-related male infertility10.1
41myoma10.1
42renal agenesis10.1
43salpingitis isthmica nodosa10.1
44premature ovarian failure10.1
45infertility due to extratesticular cause10.1
46adenocarcinoma10.1
47endometrial adenocarcinoma10.1
48ovarian disease10.1
49tuberculosis10.1
50adrenal rest tumor10.0

Graphical network of the top 20 diseases related to Infertility:



Diseases related to infertility

Clinical Features for Infertility

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Drugs & Therapeutics for Infertility

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Infertility

Drug clinical trials:

Search ClinicalTrials for Infertility

Search NIH Clinical Center for Infertility

Search CenterWatch for Infertility

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Infertility

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Sources:
22GTR
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Genetic tests related to Infertility:

id Genetic test Affiliating Genes
1 Infertility22

Anatomical Context for Infertility

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Sources:
32MalaCards
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MalaCards organs/tissues related to Infertility:

32
Ovary, Testes, Testis, Thyroid, Prostate, Endothelial, Pituitary, Spinal cord, Bone, Uterus, Kidney, Breast, Eye, Nk cells, Colon, Liver, T cells, Monocytes, Skin, Heart, Hypothalamus

Animal Models for Infertility or affiliated genes

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Publications for Infertility

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Sources:
50PubMed
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Articles related to Infertility:

(show top 50)    (show all 2149)
idTitleAuthorsYear
1
Parental attitudes toward fertility preservation in boys with cancer: context of different risk levels of infertility and success rates of fertility restoration. (23332678)
2013
2
Infertility and its treatments in association with autism spectrum disorders: a review and results from the CHARGE study. (23965925)
2013
3
Association of the gonadotrophin-regulated testicular RNA helicase gene polymorphism with human male infertility. (24168058)
2013
4
Occupational causes of male infertility. (23422246)
2013
5
Role of female pelvic anatomy in infertility. (23197390)
2013
6
Association of interleukin-1beta Ca88+a883953T gene polymorphism with human male infertility. (24067094)
2013
7
The apical ES-BTB-BM functional axis is an emerging target for toxicant-induced infertility. (23643465)
2013
8
Cultural Validation of the Turkish Version of the Infertility Self-Efficacy Scale-Short Form (TISE-SF). (24216084)
2013
9
Secondary infertility due to use of low-dose finasteride. (23070721)
2013
10
The Sertoli Cell Only Syndrome and Glaucoma in a Sex - Determining Region Y (SRY) Positive XX Infertile Male. (23998093)
2013
11
Reproducibility and reliability of semen analysis in youths at risk for infertility. (23434946)
2013
12
Intravenous immunoglobulin treatment for repeated IVF/ICSI failure and unexplained infertility: a systematic review and a meta-analysis. (24238107)
2013
13
Preservation of sperm of cancer patients: extent of use and pregnancy outcome in a tertiary infertility center. (23524529)
2013
14
Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice. (23180829)
2013
15
Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials. (22642226)
2012
16
Human seminal plasma proteome study: a search for male infertility biomarkers. (24052741)
2012
17
Re: Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. (23141270)
2012
18
Ureaplasma urealyticum in male infertility in Jilin Province, North-east China, and its relationship with sperm morphology. (21672305)
2011
19
Association between male infertility and genetic variability at the PON1/2 and GSTM1/T1 gene loci. (21561808)
2011
20
Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCIP. (21204786)
2011
21
Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks. (19996028)
2010
22
Infertility history: is it a risk factor for postpartum depression in Turkish women? (20442610)
2010
23
Distribution of male infertility specialists in relation to the male population and assisted reproductive technology centers in the United States. (19361796)
2010
24
Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population and meta-analysis. (20170288)
2010
25
Female infertility due to anovulation and defective steroidogenesis in NPC2 deficient mice. (19883728)
2010
26
MTHFR A1298C polymorphism and idiopathic male infertility. (20935396)
2010
27
Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. (18823884)
2009
28
Histologic pictures of male infertility in Yemeni patients. (19417964)
2009
29
Tracking microdeletions of the AZF region in a patrilineal line of infertile men. (18752188)
2008
30
Percutaneous vesiculodeferentography in the diagnosis of male infertility: A review of our results and the data reported in the literature. (23396640)
2008
31
An evolutionary perspective on Y-chromosomal variation and male infertility. (18399979)
2008
32
Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men. (17307919)
2007
33
Pregnancy achieved following IVF-ET after surgery for infertility with perforate transverse vaginal septum and incomplete septate uterus: case report. (18225695)
2007
34
Microarray detection of Y chromosome deletions associated with male infertility. (18062864)
2007
35
Association of the leukemia inhibitory factor gene mutation and the antiphospholipid antibodies in the peripheral blood of infertile women. (18298054)
2007
36
AZF deletions in infertile men from the Republic of Macedonia. (16862061)
2006
37
Decreased protein tyrosine phosphorylation and membrane fluidity in spermatozoa from infertile men with varicocele. (16897700)
2006
38
Successful pregnancies in 2 infertile patients with endometrial adenocarcinoma. (15103232)
2004
39
Cytogenetic and molecular analysis of the Y chromosome: absence of a significant relationship between CAG repeat length in exon 1 of the androgen receptor gene and infertility in Indian men. (14511217)
2003
40
Improvement of sexual activity, pregnancy rate, and low plasma testosterone after bilateral varicocelectomy in impotence and male infertility patients. (12746101)
2003
41
Role of cytokines in endometriosis-associated infertility. (11834864)
2002
42
Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele. (11870126)
2002
43
Lipid peroxidation and antioxidant enzymes in male infertility. (12432192)
2002
44
FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility. (12153744)
2002
45
Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: molecular markers of risk for male infertility. (11172827)
2001
46
Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility. (10767340)
2000
47
Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. (9801113)
1998
48
Efficacy assessment of highly purified follicle-stimulating hormone alone or in combination with human menopausal gonadotropin during pituitary suppression in patients undergoing GIFT for unexplained infertility. (9675561)
1998
49
Interleukins-6 and -8 levels in sera and cervical mucus of fertile, idiopathic infertile, and immunoinfertile women: implication in infertility. (8792937)
1996
50
Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. (4575636)
1973

Genetic Variations for Infertility

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Expression for genes affiliated with Infertility

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infertility

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Pathways for genes affiliated with Infertility

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Compounds for genes affiliated with Infertility

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GO Terms for genes affiliated with Infertility

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16Gene Ontology
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Biological processes related to Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:00733810.8SPAG1, BPY2C
2spermatogenesisGO:00728310.8DAZL, DAZAP1, MORC1, BPY2C

Products for genes affiliated with Infertility

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Sources for Infertility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet