MCID: INF032
MIFTS: 55

Infertility malady

Summaries for Infertility

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Infertility means not being able to become pregnant after a year of trying. if a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. infertility is fairly common. after one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. about a third of the time, infertility can be traced to the woman. in another third of cases, it is because of the man. the rest of the time, it is because of both partners or no cause can be found. there are treatments that are specifically for men or for women. some involve both partners. drugs or surgery are common treatments. happily, many couples treated for infertility go on to have babies. nih: national institute of child health and human development

MalaCards: Infertility is related to azoospermia and y chromosome infertility. An important gene associated with Infertility is DDX3Y (DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked). The drugs bromocriptine and follitropin beta have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart.

CDC:3 In general, infertility is defined as not being able to get pregnant (conceive) after one year of unprotected sex. Women who do not have regular menstrual cycles, or are older than 35 years and have not conceived during a 6-month period of trying, should consider making an appointment with a reproductive endocrinologist—an infertility specialist. These doctors may also be able to help women with recurrent pregnancy loss—2 or more spontaneous miscarriages. Pregnancy is the result of a process that has many steps. To get pregnant—

Wikipedia:64 Infertility is fundamentally the inability to conceive a baby. Infertility also refers to the state of a... more...

Aliases & Classifications for Infertility

Sources:
8Disease Ontology, 64Wikipedia, 22GTR, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

infertility 8 64 22 10 45 34 61


External Ids:

Disease Ontology8 DOID:5223
MeSH35 D007246
NCIt40 C3836

Related Diseases for Infertility

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Infertility family:

infertility due to extratesticular cause

Diseases related to Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1azoospermia31.1USP26, DDX3Y, DAZAP1, DAZL, H2BFWT
2y chromosome infertility30.7DDX3Y, HSFY1
3oligospermia30.7DAZL, DDX3Y
4sertoli cell-only syndrome30.0DDX3Y
5varicocele10.8
6polycystic ovary syndrome10.6
7trachoma10.5
8anovulation10.4
9cryptorchidism10.4
10deafness-infertility syndrome10.4
11hyperprolactinemia10.4
12cystic fibrosis10.4
13adenomyosis10.3
14testicular microlithiasis10.3
15ectopic pregnancy10.3
16n syndrome10.3
17catsper1-related nonsyndromic male infertility10.3
18congenital adrenal hyperplasia10.2
19klinefelter's syndrome10.2
20testicular cancer10.2
21spermatogenic failure 410.2
22pregnancy loss10.2
23hyperandrogenism10.2
24thrombophilia10.2
25amenorrhea10.1
26orchitis10.1
27micro syndrome10.1
28catsper-related male infertility10.1
29chronic pain10.1
30spinal cord injury10.1
31spermatogenic failure10.1
32myoma10.1
33renal agenesis10.1
34female infertility of uterine origin10.1
35salpingitis isthmica nodosa10.1
36premature ovarian failure10.1
37infertility due to extratesticular cause10.1
38adenocarcinoma10.1
39tuberculosis10.1
40young syndrome10.1
41endometriosis 110.1
42epididymitis10.1
43vesiculitis10.1
44adrenal rest tumor10.0
45trichomoniasis10.0
46bacterial vaginosis10.0
47endocervicitis10.0
48primary ciliary dyskinesia10.0
49premature menopause10.0
50ovarian hyperstimulation syndrome10.0

Graphical network of the top 20 diseases related to Infertility:



Diseases related to infertility

Clinical Features for Infertility

Drugs & Therapeutics for Infertility

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Infertility

Drug clinical trials:

Search ClinicalTrials for Infertility

Search NIH Clinical Center for Infertility

Search CenterWatch for Infertility

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Infertility

Sources:
22GTR
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Genetic tests related to Infertility:

id Genetic test Affiliating Genes
1 Infertility22

Anatomical Context for Infertility

Sources:
33MalaCards
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MalaCards organs/tissues related to Infertility:

33
Brain, Spinal cord, Heart, Colon, Kidney, Liver, Thyroid, Breast, Ovary, Uterus, Prostate, Testis, Nk cells, T cells, B cells, Endothelial, Fetal brain, Hypothalamus, Fetal liver, Fetal thyroid, Pituitary, Testis germ, Testis leydig

Animal Models for Infertility or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Infertility

Sources:
51PubMed
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Articles related to Infertility:

(show top 50)    (show all 1618)
idTitleAuthorsYear
1
The Cytochrome P4501A1 gene polymorphisms and idiopathic male infertility risk: A meta-analysis. (24316127)
2014
2
Molecular investigation of menstrual tissue for the presence of Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis collected by women with a history of infertility. (24118383)
2014
3
The relationship between sexual functioning among couples undergoing infertility treatment: a pair of perfect gloves. (23116967)
2014
4
Where are all the men? The marginalization of men in social scientific research on infertility. (23871364)
2013
5
No CAG repeat expansion of polymerase gamma is associated with male infertility in Tamil Nadu, South India. (24339545)
2013
6
MTHFR C677T and A1298C Genotypes and Haplotypes in Slovenian Couples with Unexplained Infertility Problems and in Embryonic Tissues from Spontaneous Abortions. (24265582)
2013
7
One-carbon metabolism, spermatogenesis, and male infertility. (23138010)
2013
8
The effect of mirtazapine on cisplatin-induced oxidative damage and infertility in rat ovaries. (23737712)
2013
9
Thyroid function in male infertility. (24312078)
2013
10
Dietary intake, glucose metabolism and sex hormones in women with polycystic ovary syndrome (PCOS) compared with women with non-PCOS-related infertility. (23046530)
2013
11
Tubal factor infertility and perinatal risk after assisted reproductive technology. (24084559)
2013
12
Imaging female infertility. (24072384)
2013
13
Double versus single homologous intrauterine insemination for male factor infertility: a systematic review and meta-analysis. (23708457)
2013
14
Psychosocial health of infertile Ghanaian women and their infertility beliefs. (23731032)
2013
15
Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility. (24355050)
2013
16
Recurrent ectopic pregnancy in a woman suffering from infertility due to male factor presented with heterotopic pregnancy. (22605872)
2012
17
Assessment of FSHR variants and antimA1llerian hormone in infertility patients with a reduced ovarian response to gonadotropin stimulation. (22401810)
2012
18
Male factor infertility: testis explantation for spermatogenic failure. (23027066)
2012
19
Adenomyosis and infertility. (22459492)
2012
20
Seminal volume in the investigation of male infertility. (22414356)
2012
21
AIUM practice guideline for the performance of a focused reproductive endocrinology and infertility scan. (23248819)
2012
22
Infertility as a consequence of spermagglutinating Staphylococcus aureus colonization in genital tract of female mice. (23272237)
2012
23
SEPT12 mutations cause male infertility with defective sperm annulus. (22275165)
2012
24
Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity. (22581790)
2012
25
Association between single-nucleotide polymorphisms of DNMT3L and infertility with azoospermia in Chinese men. (22116073)
2012
26
Male factor infertility: inflammasome might contribute to impaired fertility of men with spinal cord injury. (23147931)
2012
27
Evaluation of acrosome intactness status in male infertility in Mysore, South India. (23776805)
2012
28
The search for SNPs, CNVs, and epigenetic variants associated with the complex disease of male infertility. (21208142)
2011
29
Male infertility: an exploratory comparison of African American and white men. (21526584)
2011
30
Localisation of RA175 (Cadm1), a cell adhesion molecule of the immunoglobulin superfamily, in the mouse testis, and analysis of male infertility in the RA175-deficient mouse. (21486398)
2011
31
Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment. (21292261)
2011
32
The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility. (21243274)
2010
33
CD9 gene variations are not associated with female infertility in humans. (19955810)
2010
34
Does a clinical varicocele influence the relationship between testicular volume by ultrasound and testicular function in patients with infertility? (18930219)
2009
35
Novel variants in UBE2B gene and idiopathic male infertility. (18497339)
2008
36
Mitochondrial DNA Mutations in etiopathogenesis of male infertility. (19468388)
2008
37
Lead poisoning as a result of infertility treatment using herbal remedies. (16947057)
2007
38
Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. (16542438)
2006
39
Molecular evaluation of CFTR sequence variants in male infertility of testicular origin. (16128988)
2005
40
Leptin is not involved in the pathophysiology of endometriosis-related infertility. (15808381)
2005
41
Genetic control of spermiogenesis: insights from the CREM gene and implications for human infertility. (15705296)
2005
42
Re: "Is it necessary to obtain serum levels of thyroid stimulating hormone and prolactin in asymptomatic women with infertility?". (15058510)
2004
43
Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. (12874108)
2003
44
Total antioxidant status and activity of an extracellular superoxide dismutase in peritoneal fluid and plasma from women with unexplained infertility]. (11002563)
2000
45
Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome. (11095434)
2000
46
Midcycle increase of prolactin seen in normal women is absent in subjects with unexplained infertility. (9093188)
1997
47
Sexual function and clinical features of patients with Klinefelter's syndrome with the chief complaint of male infertility. (9292317)
1997
48
Immunopathogenesis of pelvic inflammatory disease and infertility -- what do we know and what shall we do? (12346974)
1996
49
A study on intratesticular aromatase activity in male infertility]. (7776564)
1995
50
Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study. (1624019)
1992

Genetic Variations for Infertility

Expression for genes affiliated with Infertility

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infertility

Search GEO for disease gene expression data for Infertility.

Pathways for genes affiliated with Infertility

Compounds for genes affiliated with Infertility

GO Terms for genes affiliated with Infertility

Sources:
16Gene Ontology
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Biological processes related to Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:00733810.8SPAG1, BPY2C
2spermatogenesisGO:00728310.8DAZL, DAZAP1, MORC1, BPY2C

Products for genes affiliated with Infertility

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Sources for Infertility

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet