Aliases & Classifications for Infertility

MalaCards integrated aliases for Infertility:

Name: Infertility 12 28 51 40 3 41 14 69 59

Classifications:



External Ids:

Disease Ontology 12 DOID:5223
MeSH 41 D007246
NCIt 46 C3836
UMLS 69 C0021359

Summaries for Infertility

MedlinePlus : 40 Infertility means not being able to become pregnant after a year of trying. If a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. Infertility is fairly common. After one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. About a third of the time, infertility can be traced to the woman. In another third of cases, it is because of the man. The rest of the time, it is because of both partners or no cause can be found. There are treatments that are specifically for men or for women. Some involve both partners. Drugs, assisted reproductive technology, and surgery are common treatments. Happily, many couples treated for infertility go on to have babies. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Infertility is related to female infertility due to zona pellucida defect and male infertility, and has symptoms including pelvic pain An important gene associated with Infertility is DAZL (Deleted In Azoospermia Like), and among its related pathways/superpathways are G alpha (s) signalling events and Fertilization. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and skin, and related phenotypes are endocrine/exocrine gland and reproductive system

CDC : 3 Pregnancy is the result of a process that has many steps.

PubMed Health : 59
About infertility: Not being able to have children is often a source of great emotional turmoil. Many men and women take it for granted that they will be able to have children. If they are not able to conceive, many couples start looking for medical help at some point. A number of different treatments are available, depending on the possible causes of infertility.Problems conceiving a child are defined by medical experts as “infertility” if a couple has had regular unprotected sex for one year without the woman becoming pregnant.

Wikipedia : 72 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

Related Diseases for Infertility

Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 female infertility due to zona pellucida defect 33.7 ZP1 ZP3
2 male infertility 33.5 CATSPER2 DAZ1 DAZ4 DAZL DDX3Y DNAH1
3 oocyte maturation defect 1 33.1 CYP19A1 ZP1
4 spermatogenic failure, y-linked, 2 32.7 DAZ1 DAZ4 DDX3Y USP9Y
5 azoospermia 32.3 DAZ1 DAZ4 DAZL DDX3Y FSHB USP9Y
6 spermatogenic failure, x-linked, 1 32.3 DAZ1 DAZ4 DAZL DDX3Y USP9Y
7 anovulation 32.2 CYP19A1 FSHB FSHR
8 cryptorchidism, unilateral or bilateral 32.1 CYP19A1 DAZ1 INSL3 NR5A1
9 46,xx sex reversal 1 31.4 FSHR NR5A1
10 amenorrhea 30.3 FSHB FSHR LHCGR NR5A1
11 ovarian disease 30.3 CYP19A1 FSHR ZP1 ZP3
12 premature ovarian failure 1 30.2 CYP19A1 DAZL FSHR INHA NR5A1
13 ovarian hyperstimulation syndrome 30.2 CYP19A1 FSHR LHCGR
14 leydig cell tumor 29.6 CYP19A1 INSL3 LHCGR
15 deafness-infertility syndrome 12.4
16 y chromosome infertility 12.3
17 catsper1-related nonsyndromic male infertility 12.1
18 spermatogenic failure 6 12.0
19 female infertility of uterine origin 12.0
20 non-syndromic male infertility due to sperm motility disorder 12.0
21 catsper-related male infertility 12.0
22 rare idiopathic male infertility 11.9
23 spermatogenic failure 5 11.9
24 infertility due to extratesticular cause 11.9
25 macrozoospermia 11.8
26 male infertility with spermatogenesis disorder 11.8
27 male infertility with spermatogenesis disorder due to single gene mutation 11.8
28 male infertility with teratozoospermia due to single gene mutation 11.8
29 female infertility due to oocyte meiotic arrest 11.8
30 spermatogenic failure 1 11.6
31 young syndrome 11.5
32 spermatogenic failure 7 11.5
33 spermatogenic failure, x-linked, 2 11.4
34 spermatogenic failure 17 11.4
35 endometriosis 11.4
36 pelvic inflammatory disease 11.3
37 polycystic ovary syndrome 11.3
38 turner syndrome 11.2
39 cystic fibrosis 11.2
40 hyperprolactinemia 11.2
41 hypogonadotropic hypogonadism 11.1
42 testicular microlithiasis 11.1
43 primary ciliary dyskinesia 11.1
44 spermatogenic failure 3 11.1
45 testicular cancer 11.1
46 mumps 11.1
47 vas deferens, congenital bilateral aplasia of 11.1
48 chlamydia 11.1
49 leiomyoma, uterine 11.1
50 hypogonadism 11.1

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility

Symptoms & Phenotypes for Infertility

UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 CYP19A1 DPY19L2 FSHB FSHR INHA INSL3
2 reproductive system MP:0005389 9.4 DNAH1 DPY19L2 FSHB FSHR INHA INSL3

Drugs & Therapeutics for Infertility

PubMedHealth treatment related to Infertility: 59

There are a number of different treatments for infertility. The exact kind of treatment will mainly be determined by what sort of problem has been diagnosed in the woman or man. For instance, hormones may be used if the woman has an abnormal menstrual cycle. Surgery may be helpful if she has fibroids. Some causes of infertility in men can also be treated with hormones or surgery.If not enough sperm is produced or if the sperm cells don't move enough, the semen can be transferred directly to the woman’s womb. This procedure is called insemination. Artificial insemination is also a treatment option if the couple can't have sex or if the sperm can't pass through the cervical mucus. One alternative is artificial fertilization outside the body (in vitro fertilization, or IVF): In this procedure, eggs are removed from the woman’s ovaries through the vagina using a thin hollow needle, and then combined with sperm from the man. Before the eggs are removed, the woman has hormone therapy to stimulate her ovaries to release several mature eggs during the course of a single menstrual cycle. This hormone therapy can have very strong and unpleasant side effects.The actual fertilization takes place outside of the woman's body in a laboratory. In IVF, sperm cells are added to an egg cell and the fertilization process happens on its own. In intracytoplasmic sperm injection (ICSI), one sperm cell is injected directly into an egg using a fine needle.If the fertilization is a success and the egg cells continue to develop, the doctor implants up to three embryos into the womb. In rare cases more egg cells develop into embryos. The woman can then decide to have them frozen (cryopreserved) or destroyed. This also applies to egg cells in a stage of development called the pronuclear stage, in which the chromosome sets from the sperm and egg cells have not yet fully joined together. Cryopreserved embryos or fertilized egg cells can then be thawed out for use in a later cycle if the first transfer is not successful.

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1199)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
2
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 46507594 772
3
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 50-02-2 5743
5
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 6251 453
6
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
7
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
8
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 7440-66-6 32051 23994
9
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
10
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
11
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757
12
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
13
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
14
Tamoxifen Approved Phase 4,Phase 3 10540-29-1 2733526
15
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
16
Midazolam Approved, Illicit Phase 4,Phase 1,Phase 2 59467-70-8 4192
17
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
18
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
19
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 57-27-2 5288826
20
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
21
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 4091 14219
22
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 9004-61-9 53477741 24759
23
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
24
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
25
Succinylcholine Approved Phase 4 306-40-1 5314
26
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 56-81-5 753
27
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 5311128 47725
28
Buserelin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57982-77-1
29
Formaldehyde Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-00-0 712
30
Neomycin Approved, Vet_approved Phase 4,Phase 3,Phase 1 1404-04-2 8378
31
Ticlopidine Approved Phase 4 55142-85-3 5472
32
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 657311 5754
33
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
34
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
35
Cabergoline Approved Phase 4,Phase 2,Phase 3,Phase 1 81409-90-7 54746
36
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
37
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 299-42-3 9294
38
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 3,Phase 1 501-36-0 445154
39
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
40
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7553-56-2 807
41
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
42
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
43
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
44
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 657181 3911
45
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
46 Cisatracurium Approved, Experimental Phase 4 96946-41-7
47
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 38396-39-3, 2180-92-9 2474
48
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
49
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
50
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583

Interventional clinical trials:

(show top 50) (show all 3987)

# Name Status NCT ID Phase Drugs
1 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
2 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
3 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
4 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
5 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
6 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
7 Metformin in Infertile PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
8 Biosimilar Versus Urinary Gonadotropins Unknown status NCT02503605 Phase 4 Biosimilar recombinant FSH;Urinary FSH
9 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
10 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
11 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4 Human Chorionic Gonadotropin (HCG)
12 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
13 Methylprednisolone Addition in IVF Treatment of Infertile Couples Unknown status NCT01220791 Phase 4
14 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
15 The Role of Microsurgery in Surgical Treatment of Varicocele. Unknown status NCT02722187 Phase 4
16 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
17 the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer . Unknown status NCT02655146 Phase 4 triptorelin 0.1;E2;Progesterone;triptorelin 3.75mg
18 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Unknown status NCT02494180 Phase 4 fentanyl;pethidine;Diazepam;Midazolam
19 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4 Elonva;Puregon
20 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4 Corifollitropin alfa
21 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
22 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
23 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
24 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
25 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4 crinone (progesterone 8%, vaginal application)
26 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4 HCG;Lupron Trigger;Dual Trigger
27 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
28 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
29 Comparison Between Recombinant Versus Urinary hCG for Ovulation Induction in High Responders Unknown status NCT00415766 Phase 4 rHCG 250ug;uHCG 5000 IU;uHCG 7500 IU
30 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
31 Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI Unknown status NCT02696330 Phase 4 clopidogrel;enoxaparin;placebo
32 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
33 Use of G-CSF Supplemented IVF Medium in Patients Undergoing IVF Unknown status NCT02651285 Phase 4
34 Use of Corifolitropin Alfa in Oocyte Donors Unknown status NCT02213627 Phase 4 Corifollitropin alfa;Recombinant FSH;HP-hMG
35 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
36 Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF Unknown status NCT02070198 Phase 4 Long acting FSH and GnRH antagonist;Daily FSH and GnRH antagonist;Triptorelin and recombinant FSH
37 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
38 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
39 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
40 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Unknown status NCT02165917 Phase 4
41 The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement Unknown status NCT01312415 Phase 4 Levobupivacaine;Intrathecal morphine
42 The Effect of Intramuscular Dexmedetomidine on Emergence Agitation in Children Undergoing With or Without Tube Insertion Under General Anesthesia Unknown status NCT01535287 Phase 4 Dexmedetomidine
43 Negative Pressure Wound Therapy After Cesarean Delivery Unknown status NCT01637870 Phase 4
44 Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate Unknown status NCT00480376 Phase 4 ofloxacin;gentamicin
45 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Unknown status NCT02097017 Phase 4 Lidocaine
46 Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults Unknown status NCT01967368 Phase 4 Intanza;Vaxigrip
47 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
48 Spinal Cord Stimulation (SCS) in Refractory Angina Unknown status NCT00121654 Phase 4
49 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4 Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
50 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: infertility

Genetic Tests for Infertility

Genetic tests related to Infertility:

# Genetic test Affiliating Genes
1 Infertility 28

Anatomical Context for Infertility

MalaCards organs/tissues related to Infertility:

38
Ovary, Testes, Skin, Breast, Bone, Eye, Prostate

Publications for Infertility

Articles related to Infertility:

(show top 50) (show all 2739)
# Title Authors Year
1
Effect of varicocelectomy and/or mast cells stabilizer on sperm DNA fragmentation in infertile patients with varicocele. ( 29195028 )
2018
2
Knowledge and perceptions of infertility in female cancer survivors and their parents. ( 29427193 )
2018
3
Fear and infertility research. ( 29419382 )
2018
4
Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception. ( 29135053 )
2018
5
Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options. ( 29402199 )
2018
6
Derivation of human induced pluripotent stem cell line (HUSTi001-A) from a 40-year-old patient with idiopathic infertility. ( 29414604 )
2018
7
The effect of low-dose ovarian stimulation with HMG plus progesterone on pregnancy outcome in women with history of recurrent pregnancy loss and secondary infertility: a retrospective cohort study. ( 29433402 )
2018
8
Association of the common SNPs in RNF212, STAG3 and RFX2 gene with male infertility with azoospermia in Chinese population. ( 29277047 )
2018
9
Nationwide survey of urological specialists regarding male infertility: results from a 2015 questionnaire in Japan. ( 29371820 )
2018
10
Role of Withania somnifera (Ashwagandha) in the management of male infertility. ( 29277366 )
2018
11
Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. ( 29371828 )
2018
12
Spirituality, infertility-related stress, and quality of life in Brazilian infertile couples: Analysis using the actor-partner interdependence mediation model. ( 29399819 )
2018
13
Bilateral is superior to unilateral varicocelectomy in infertile males with left clinical and right subclinical varicocele: a prospective randomized controlled study. ( 29210007 )
2018
14
Genetic intersection of male infertility and cancer. ( 29307395 )
2018
15
A Dyadic Approach to Infertility Stress, Marital Adjustment, and Depression on Quality of Life in Infertile Couples. ( 29436974 )
2018
16
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. ( 29447380 )
2018
17
Amenorrhoea and reversible infertility due to obstructive hydrocephalus: literature review and case report. ( 29430977 )
2018
18
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. ( 29449551 )
2018
19
Mapping Out the under-Recognized Burden of Human Infertility Linked to<i>Schistosoma haematobium</i>Infection. ( 29405110 )
2018
20
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia. ( 29365104 )
2018
21
Lack of association between aryl hydrocarbon receptor gene Arg554Lys polymorphism and male infertility risk: A systematic review and meta-analysis. ( 29427904 )
2018
22
Infertile polycystic ovary syndrome patients undergoing in vitro fertilization with the gonadotropin-releasing hormone-antagonist protocol: role of hyperandrogenism. ( 29376451 )
2018
23
Can Tangier disease cause male infertility? A case report and an overview on genetic causes of male infertility and hormonal axis involved. ( 29198592 )
2018
24
Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men. ( 29292525 )
2018
25
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives. ( 29315416 )
2018
26
Infertility treatment strategy involving combined freeze-all embryos and single vitrified-warmed embryo transfer during hormonal replacement cycle for in vitro fertilization of women with hypogonadotropic hypogonadism. ( 29436143 )
2018
27
Non-Apnea Sleep Disorder Increases the Risk of Subsequent Female Infertility-A Nationwide Population-Based Cohort Study. ( 29136234 )
2018
28
Comparison of The Efficacy and Safety of Palomo, Ivanissevich and Laparoscopic Varicocelectomy in Iranian Infertile Men with Palpable Varicocele. ( 29334212 )
2018
29
Impact of cancer treatment on risk of infertility and diminished ovarian reserve in women with polycystic ovary syndrome. ( 29428311 )
2018
30
Male Infertility Diagnosis and Treatment in the Era of InA Vitro Fertilization and Intracytoplasmic Sperm Injection. ( 29406062 )
2018
31
Unexplained infertility patients present the mostly impaired levels of progesterone receptors: Prospective observational study. ( 29450939 )
2018
32
Male infertility: a biomarker of individual and familial cancer risk. ( 29307404 )
2018
33
Usefulness of Testicular Volume, Apparent Diffusion Coefficient, and Normalized Apparent Diffusion Coefficient in the MRI Evaluation of Infertile Men With Azoospermia. ( 29364721 )
2018
34
The Effect of Omega-3 Fatty Acids, EPA, and/or DHA on Male Infertility: A Systematic Review and Meta-analysis. ( 29451828 )
2018
35
The effects of tomato juice on male infertility. ( 28049263 )
2017
36
Comparing the Frequency of Endometritis in Unexplained Infertility and Anovulatory Infertility. ( 29285481 )
2017
37
Y chromosome microdeletions and varicocele as aetiological factors of male infertility: A cross-sectional study. ( 29265486 )
2017
38
Associations between male infertility and ancestry in South Americans: a case control study. ( 28747152 )
2017
39
Leptin and leptin-receptor polymorphisms in fertile and infertile men. ( 27983873 )
2017
40
Infertility in an adult cohort with primary ciliary dyskinesia: phenotype-gene association. ( 29122913 )
2017
41
eNOS gene T786C, G894T and 4a4b polymorphisms and male infertility susceptibility: a meta-analysis. ( 27373555 )
2017
42
AntimA1llerian hormone levels and antral follicle counts are not reduced compared with community controls in patients with rigorously defined unexplained infertility. ( 29202959 )
2017
43
"Infertility in an adult cohort with primary ciliary dyskinesia: phenotype-gene association." Gert Jan Vanaken, Laurence Bassinet, Mieke Boon, Rahma Mani, Isabelle HonorAc, Jean-Francois Papon, Harry Cuppens, Martine Jaspers, Natalie Lorent, AndrAc Coste, Estelle Escudier, Serge Amselem, Bernard Maitre, Marie Legendre and Sophie Christin-Maitre.<i>Eur Respir J</i>2017; 50: 1700314. ( 29242267 )
2017
44
Pregnancy, Hormonal Treatments for Infertility, Contraception, and Menopause in Women After Ischemic Stroke: A Consensus Document. ( 28070003 )
2017
45
Fluorescence in situ hybridisation sperm examination is significantly impaired in all categories of male infertility. ( 28762516 )
2017
46
Varicocele and male infertility. ( 28675168 )
2017
47
Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Male Infertility in Asian Population. ( 28811683 )
2017
48
Screening of Two Neighboring CFTR Mutations in Iranian Infertile Men with Non-Obstructive Azoospermia. ( 28042420 )
2017
49
Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility. ( 27813378 )
2017
50
Erratum: Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]. ( 28496306 )
2017

Variations for Infertility

ClinVar genetic disease variations for Infertility:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NPHP4 NM_015102.4(NPHP4): c.2044C> T (p.Arg682Ter) single nucleotide variant Pathogenic/Likely pathogenic rs137852920 GRCh37 Chromosome 1, 5964776: 5964776

Copy number variations for Infertility from CNVD:

7 (show all 50)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion AZFb infertility
13 266750 Y 1 57772954 Microdeletion AZFc infertility
14 266796 Y 11300000 27200000 Deletion AZF infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZFa infertility
17 266827 Y 11300000 27200000 Microdeletion AZFb infertility
18 266828 Y 11300000 27200000 Microdeletion AZFc infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4LY infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion GOLGAZLY infertility
27 266840 Y 11300000 27200000 Microdeletion NAHR infertility
28 266841 Y 11300000 27200000 Microdeletion NOA infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF infertility
32 266975 Y 174481503 174538309 Microdeletions AZF infertility
33 266976 Y 174481503 174538309 Microdeletions AZFA infertility
34 267088 Y 23407118 25740308 Copy number TTTY17 Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4LY Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation ATPase6 Infertility
49 267527 mtDNA 1 16569 Mutation CYTB Infertility
50 267528 1 183532144 183553084 Mutation ND1 Infertility