MCID: INF032
MIFTS: 55

Infertility malady

Reproductive diseases category

Summaries for Infertility

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Sources:
35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Infertility means not being able to become pregnant after a year of trying. if a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. infertility is fairly common. after one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. about a third of the time, infertility can be traced to the woman. in another third of cases, it is because of the man. the rest of the time, it is because of both partners or no cause can be found. there are treatments that are specifically for men or for women. some involve both partners. drugs or surgery are common treatments. happily, many couples treated for infertility go on to have babies. nih: national institute of child health and human development

MalaCards: Infertility is related to male infertility and azoospermia. An important gene associated with Infertility is SPAG1 (sperm associated antigen 1). The drugs bromocriptine and 2-bromoergocryptine mesylate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis, and related mouse phenotype reproductive system.

CDC:4 In general, infertility is defined as not being able to get pregnant (conceive) after one year of unprotected sex. Women who do not have regular menstrual cycles, or are older than 35 years and have not conceived during a 6-month period of trying, should consider making an appointment with a reproductive endocrinologist—an infertility specialist. These doctors may also be able to help women with recurrent pregnancy loss—2 or more spontaneous miscarriages. Pregnancy is the result of a process that has many steps. To get pregnant—

Wikipedia:66 Infertility is fundamentally the inability to conceive offspring. Infertility also refers to the state... more...

Aliases & Classifications for Infertility

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Sources:
9Disease Ontology, 66Wikipedia, 23GTR, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

infertility 9 66 23 11 46 35 63


External Ids:

Disease Ontology9 DOID:5223
NCIt41 C3836
MeSH36 D007246

Related Diseases for Infertility

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1male infertility31.8DDX3Y, DAZL, USP26, ODF1
2azoospermia31.0DDX3Y, DAZL, USP26, H2BFWT, FKBP6
3y chromosome infertility30.8DDX3Y
4oligospermia30.8DAZL, DDX3Y
5sertoli cell-only syndrome30.3DDX3Y
6endometriosis10.8
7varicocele10.8
8polycystic ovary syndrome10.6
9cryptorchidism10.5
10anovulation10.5
11salpingitis10.4
12hypogonadism10.4
13hyperprolactinemia10.4
14obesity10.4
15peritonitis10.4
16thyroiditis10.4
17prostatitis10.4
18deafness-infertility syndrome10.4
19cystic fibrosis10.4
20cervicitis10.4
21pelvic inflammatory disease10.4
22leukemia10.3
23adenomyosis10.3
24testicular microlithiasis10.3
25endometritis10.3
26ectopic pregnancy10.3
27congenital adrenal hyperplasia10.3
28hypogonadotropism10.3
29vaginitis10.3
30epididymitis10.3
3121-hydroxylase deficiency10.2
32klinefelter's syndrome10.2
33hyperandrogenism10.2
34hypothyroidism10.2
35catsper1-related nonsyndromic male infertility10.2
36pregnancy loss10.2
37endotheliitis10.2
38female infertility of uterine origin10.2
39testicular cancer10.2
40thrombophilia10.2
41orchitis10.2
42amenorrhea10.2
43impotence10.2
44catsper-related male infertility10.2
45spinal cord injury10.2
46spermatogenic failure10.2
47female infertility due to fertilization defect10.2
48female infertility due to zona pellucida defect10.2
49myoma10.1
50premature ovarian failure10.1

Graphical network of the top 20 diseases related to Infertility:



Diseases related to infertility

Symptoms for Infertility

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Drugs & Therapeutics for Infertility

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Infertility

Drug clinical trials:

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Search NIH Clinical Center for Infertility

Search CenterWatch for Infertility

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Infertility

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Sources:
23GTR
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Genetic tests related to Infertility:

id Genetic test Affiliating Genes
1 Infertility23

Anatomical Context for Infertility

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Sources:
34MalaCards
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MalaCards organs/tissues related to Infertility:

34
Ovary, Testes, Testis, Thyroid, Prostate, Endothelial, Pituitary, Spinal cord, Kidney, Bone, Uterus, Eye, Breast, Skin, T cells, Nk cells, Monocytes, Colon, Heart, Liver, Hypothalamus

Animal Models for Infertility or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Infertility:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.1FKBP6, ODF1, LHB, OAZ3, SPAG6, SPACA1

Publications for Infertility

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Sources:
53PubMed
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Articles related to Infertility:

(show top 50)    (show all 2126)
idTitleAuthorsYear
1
The field of male infertility moves fast! (24286780)
2014
2
Infertility, in vitro fertilization and congenital tuberculosis. (23803676)
2013
3
Where are all the men? The marginalization of men in social scientific research on infertility. (23871364)
2013
4
Developments in infertility counselling and its accreditation. (23548094)
2013
5
Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. (23512232)
2013
6
Genetic testing for hearing loss in the United States should include deletion/duplication analysis for the deafness/infertility locus at 15q15.3. (23648117)
2013
7
The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility. (23415969)
2013
8
Kisspeptin: Role in reproduction and implications for infertility management. (23162367)
2012
9
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility. (21429654)
2011
10
Higher proportion of haploid round spermatids and spermatogenic disomy rate in relation to idiopathic male infertility. (21094989)
2011
11
Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1. (20887963)
2010
12
Histopathologic patterns of testicular biopsies in infertile azoospermic men with varicocele. (20416871)
2010
13
Expression of angiotensin II type 1 (AT1) and angiotensin II type 2 (AT2) receptors in human granulosa-lutein (GL) cells: correlation with infertility diagnoses. (19524223)
2010
14
Correlation of the expression of integrin I+VI^3 in endometrium and peripheral blood lymphocytes in infertile patients. (20224109)
2010
15
Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. (20845296)
2010
16
CA repeat and RsaI polymorphisms in ERbeta gene are not associated with infertility in Indian men. (17916182)
2009
17
Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis]. (19947564)
2009
18
Microsurgical varicocelectomy for infertile men with oligospermia: differential effect of bilateral and unilateral varicocele on pregnancy outcomes. (19338535)
2009
19
Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. (19517319)
2009
20
Length of androgen receptor-CAG repeats in fertile and infertile Egyptian men. (19168451)
2009
21
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. (19129711)
2009
22
Mitochondrial DNA mutations and male infertility. (21088712)
2009
23
Antioxidant therapy in male infertility. (18423251)
2008
24
Screening of 'Y' chromosome microdeletions in Iranian infertile males. (19562056)
2008
25
Hysteroscopic treatment of atypical polypoid adenomyoma diagnosed incidentally in a young infertile woman. (17706212)
2008
26
Decreased anti-MA1llerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis. (17624337)
2008
27
Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men. (17307919)
2007
28
Autosomal DAZL single nucleotide polymorphisms not associated with male infertility in northeast China]. (17918711)
2007
29
Serum leptin correlates in infertile oligozoospermic males. (17714215)
2007
30
Serum leptin level in women with unexplained infertility. (17485120)
2007
31
AZF deletions in infertile men from the Republic of Macedonia. (16862061)
2006
32
Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India. (16372124)
2006
33
Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. (16045534)
2005
34
Molecular evaluation of CFTR sequence variants in male infertility of testicular origin. (16128988)
2005
35
Body composition characteristics and fat distribution patterns in young infertile women. (15037399)
2004
36
Aromatase inhibitors--is it a new opportunity in the treatment of infertility?]. (15185531)
2004
37
Genetic analysis of three polymorphic sites of the luteinizing hormone beta-subunit gene in infertile Korean men with nonobstructive azoospermia. (12620433)
2003
38
Idiopathic cases of male infertility from a region in India show low incidence of Y-chromosome microdeletion. (14517364)
2003
39
Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility. (12724276)
2003
40
Cytogenetic and molecular analysis of the Y chromosome: absence of a significant relationship between CAG repeat length in exon 1 of the androgen receptor gene and infertility in Indian men. (14511217)
2003
41
CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations. (12399527)
2002
42
Detection of fractalkine in human seminal plasma and its role in infertile patients. (12042278)
2002
43
Enhanced T cells interactions with extracellular matrix proteins in infertile women with endometriosis. (11841847)
2002
44
Anti-sperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1, the H6-3C4 antigen, and CD52. (10735589)
2000
45
Sperm surface protein profiles of fertile and infertile men: search for a diagnostic molecular marker. (10624499)
1999
46
Determination of interleukin-11 in seminal plasma and elevated IL-11 in seminal plasma of infertile patients with urogenital infection. (9805146)
1998
47
Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. (9360540)
1997
48
Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. (7850869)
1994
49
Primary amenorrhoea and infertility due to a mutation in the beta- subunit of follicle-stimulating hormone. (8220432)
1993
50
Endometriosis and anovulation: a coexisting problem in the infertile female. (1275031)
1976

Variations for Infertility

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Expression for genes affiliated with Infertility

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infertility

Search GEO for disease gene expression data for Infertility.

Pathways for genes affiliated with Infertility

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Compounds for genes affiliated with Infertility

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GO Terms for genes affiliated with Infertility

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17Gene Ontology
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Biological processes related to Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:0073389.8BPY2C, SPAG1
2spermatogenesisGO:0072838.1BPY2C, FKBP6, ODF1, OAZ3, DAZL

Molecular functions related to Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:0001669.9RBMXL2, NT5C1B, DAZL

Products for genes affiliated with Infertility

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Sources for Infertility

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet