Aliases & Classifications for Infertility

Aliases & Descriptions for Infertility:

Name: Infertility 12 29 52 41 3 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5223
MeSH 42 D007246
NCIt 47 C3836
UMLS 69 C0021359

Summaries for Infertility

MedlinePlus : 41 infertility means not being able to become pregnant after a year of trying. if a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. infertility is fairly common. after one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. about a third of the time, infertility can be traced to the woman. in another third of cases, it is because of the man. the rest of the time, it is because of both partners or no cause can be found. there are treatments that are specifically for men or for women. some involve both partners. drugs, assisted reproductive technology, and surgery are common treatments. happily, many couples treated for infertility go on to have babies. nih: national institute of child health and human development

MalaCards based summary : Infertility is related to endometriosis and leydig cell hypoplasia with pseudohermaphroditism, and has symptoms including pelvic pain An important gene associated with Infertility is DAZL (Deleted In Azoospermia Like), and among its related pathways/superpathways are Nuclear Receptor transcription pathway and Fertilization. The drugs Metformin and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 71 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

Related Diseases for Infertility

Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 334)
id Related Disease Score Top Affiliating Genes
1 endometriosis 32.0 GNRH1 PRL
2 leydig cell hypoplasia with pseudohermaphroditism 31.7 CYP19A1 FSHR LHCGR
3 endocervicitis 29.9 ESR2 FSHR PGR
4 male infertility 12.4
5 deafness-infertility syndrome 12.3
6 y chromosome infertility 12.2
7 catsper1-related nonsyndromic male infertility 12.0
8 catsper-related male infertility 11.9
9 female infertility of uterine origin 11.9
10 non-syndromic male infertility due to sperm motility disorder 11.9
11 rare idiopathic male infertility 11.8
12 spermatogenic failure 6 11.8
13 infertility due to extratesticular cause 11.7
14 spermatogenic failure 5 11.7
15 male infertility with spermatogenesis disorder 11.7
16 male infertility with spermatogenesis disorder due to single gene mutation 11.7
17 male infertility with teratozoospermia due to single gene mutation 11.7
18 macrozoospermia 11.6
19 oocyte maturation defect 11.5
20 young syndrome 11.4
21 spermatogenic failure 7 11.3
22 spermatogenic failure, y-linked, 2 11.3
23 spermatogenic failure, x-linked, 2 11.2
24 spermatogenic failure 17 11.2
25 azoospermia 11.2
26 pelvic inflammatory disease 11.2
27 polycystic ovary syndrome 11.2
28 sertoli cell-only syndrome 11.1
29 turner syndrome 11.1
30 cryptorchidism 11.1
31 cystic fibrosis 11.1
32 hyperprolactinemia 11.1
33 testicular microlithiasis 11.0
34 klinefelter's syndrome 11.0
35 primary ciliary dyskinesia 11.0
36 mumps 11.0
37 congenital bilateral absence of vas deferens 11.0
38 uterine fibroid 11.0
39 oligospermia 11.0
40 hypogonadism 11.0
41 anovulation 11.0
42 testicular cancer 10.9
43 testicular germ cell tumor 10.9
44 schistosomiasis 10.9
45 gonadal dysgenesis 10.9
46 47,xyy syndrome 10.9
47 3-beta-hydroxysteroid dehydrogenase, type ii, deficiency 10.7
48 perrault syndrome 2 10.7
49 ciliary dyskinesia, primary, 32 10.7
50 ciliary dyskinesia, primary, 18 10.7

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility

Symptoms & Phenotypes for Infertility

UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CATSPER2 CYP19A1 DPY19L2 ESR2 FSHB FSHR
2 endocrine/exocrine gland MP:0005379 9.97 FSHR GNRH1 INHA LHCGR NR5A1 PGR
3 reproductive system MP:0005389 9.47 CATSPER2 CYP19A1 DPY19L2 ESR2 FSHB FSHR
4 neoplasm MP:0002006 9.43 ESR2 FSHR GNRH1 INHA PGR PRL

Drugs & Therapeutics for Infertility

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1158)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
2
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
3
Ganirelix Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 123246-29-7, 124904-93-4 25081094
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
6
Cetrorelix Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 120287-85-6 16129715 25074887
7
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757 53477783
8
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 50-02-2 5743
10
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 3911 657181
11
Dimenhydrinate Approved Phase 4 523-87-5 441281
12
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 9004-61-9 53477741 24759
13
Selenium Approved, Vet_approved Phase 4,Phase 3,Phase 2 7782-49-2
14
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
15
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
16
Levobupivacaine Approved Phase 4 27262-47-1 92253
17
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
18
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
19
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
20
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
21
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
22
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
23
Aluminum hydroxide Approved Phase 4,Phase 3,Phase 2,Phase 1 21645-51-2
24
Neomycin Approved, Vet_approved Phase 4,Phase 3,Phase 1 1404-04-2 8378
25
Ropivacaine Approved Phase 4,Phase 3,Phase 2 84057-95-4 71273 175805
26
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
28
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
29
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
30
Menotropins Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 61489-71-2 5360545
31
Liraglutide Approved Phase 4 204656-20-2
32
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-56-1 9552079 2713
33
Buserelin Approved Phase 4,Phase 3,Phase 1,Phase 2 57982-77-1
34
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 2216-51-5 16666
35
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
36
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
37
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
38
Povidone-iodine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 25655-41-8
39
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
40
Glycerol Approved, Experimental Phase 4,Phase 2,Phase 1 56-81-5 753
41
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
42
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
43
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
44
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 616-91-1 12035
45
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
46
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
47
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 216974-75-3
48
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
49
Petrolatum Approved Phase 4,Phase 2,Phase 3,Phase 1 8009-03-8
50
Benzocaine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show top 50) (show all 3614)
id Name Status NCT ID Phase
1 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
2 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4
3 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4
4 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
5 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
6 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4
7 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4
8 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4
9 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4
10 Methylprednisolone Addition in IVF Treatment of Infertile Couples Unknown status NCT01220791 Phase 4
11 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4
12 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4
13 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4
14 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4
15 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
16 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
17 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4
18 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4
19 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4
20 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4
21 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4
22 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4
23 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
24 Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF Unknown status NCT02070198 Phase 4
25 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4
26 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
27 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
28 The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement Unknown status NCT01312415 Phase 4
29 The Effect of Intramuscular Dexmedetomidine on Emergence Agitation in Children Undergoing With or Without Tube Insertion Under General Anesthesia Unknown status NCT01535287 Phase 4
30 Negative Pressure Wound Therapy After Cesarean Delivery Unknown status NCT01637870 Phase 4
31 Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate Unknown status NCT00480376 Phase 4
32 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Unknown status NCT02097017 Phase 4
33 Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults Unknown status NCT01967368 Phase 4
34 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
35 Spinal Cord Stimulation (SCS) in Refractory Angina Unknown status NCT00121654 Phase 4
36 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4
37 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4
38 The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound Unknown status NCT00813631 Phase 4
39 Cellular Immunity in Adult Hepatitis B-vaccinated Serologic Non-responders Unknown status NCT01451801 Phase 4
40 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4
41 The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement Unknown status NCT01312077 Phase 4
42 Serratus Anterior Plane Block Versus Paravertebral Block for Postmastectomy Analgesia Unknown status NCT02103946 Phase 4
43 Home Usage of Conception Kit Instructions Unknown status NCT00326651 Phase 4
44 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4
45 Role of Laparoscopy in Unexplained Infertility Completed NCT00886041 Phase 4
46 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4
47 The Effect of LMWH on ICSI in Patients With Unexplained Infertility and Negative Immunological Markers Completed NCT02861105 Phase 4
48 Second-Line Treatments for Anovulatory Infertility in PCOS Patients Completed NCT00558077 Phase 4
49 Treatment of Anovulatory Infertility in PCOS Patients Completed NCT00471523 Phase 4
50 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: infertility

Genetic Tests for Infertility

Genetic tests related to Infertility:

id Genetic test Affiliating Genes
1 Infertility 29

Anatomical Context for Infertility

MalaCards organs/tissues related to Infertility:

39
Ovary, Testes, Testis, Thyroid, Prostate, Endothelial, Pituitary

Publications for Infertility

Articles related to Infertility:

(show top 50) (show all 2604)
id Title Authors Year
1
Erratum: Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]. ( 28496306 )
2017
2
In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility. ( 27802063 )
2017
3
The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis. ( 28050928 )
2017
4
Comparative analysis of testis transcriptomes associated with male infertility in cattleyak. ( 27865410 )
2017
5
The effects of tomato juice on male infertility. ( 28049263 )
2017
6
Comparative study in infertile couples with and without Chlamydia trachomatis genital infection. ( 28086915 )
2017
7
Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility. ( 28089575 )
2017
8
The Utility of Sex Hormone Binding Globulin in Hypogonadism and Infertile Males. ( 28087298 )
2017
9
Assessing factors associated with infertility using a couple-based approach. ( 28084027 )
2017
10
Delayed treatment of undescended testes may promote hypogonadism and infertility. ( 28070708 )
2017
11
Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. ( 27864361 )
2017
12
Ultrasound in Infertility Treatments. ( 28059846 )
2017
13
Proportion of Tubal Factor Infertility due to Chlamydia: Finite Mixture Modeling of Serum Antibody Titers. ( 28062393 )
2017
14
MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis. ( 28081209 )
2017
15
Activity of LPO Processes in Women with Polycystic Ovarian Syndrome and Infertility. ( 28091905 )
2017
16
Implantation Failure Is Associated With Increased I+-Inhibin and I^-Glycan Gene Expression in Secretory Phase Endometrium: Nested Case-Control Study of Infertile Women Undergoing IVF/Fresh Embryo Transfer. ( 27628954 )
2017
17
Pregnancy, Hormonal Treatments for Infertility, Contraception, and Menopause in Women After Ischemic Stroke: A Consensus Document. ( 28070003 )
2017
18
Don't Give Up! A Cyber-ethnography and Discourse Analysis of an Online Infertility Patient Forum. ( 28063090 )
2017
19
Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease. ( 27898568 )
2017
20
Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility. ( 28018158 )
2017
21
TTY2 genes deletions as genetic risk factor of male infertility. ( 28364784 )
2017
22
Screening of Two Neighboring CFTR Mutations in Iranian Infertile Men with Non-Obstructive Azoospermia. ( 28042420 )
2017
23
Maternal uniparental disomy of chromosome 15 and concomitant STRC and CATSPER2 deletion-mediated deafness-infertility syndrome. ( 28317263 )
2017
24
Randomised clinical trial of comparing effects of acupuncture and varicocelectomy on sperm parameters in infertile varicocele patients. ( 28083932 )
2017
25
Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. ( 26970590 )
2016
26
Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis. ( 26584688 )
2016
27
Evaluation of serum level of Osteocalcin hormone in male infertility. ( 28000970 )
2016
28
CAG-repeat polymorphisms in the polymerase I^ gene and male infertility: a meta-analysis. ( 26790834 )
2016
29
Ureaplasma urealyticum in male genital tract: a hidden risk factor for male infertility. ( 27897333 )
2016
30
Epigenetic alterations of CYP19A1 gene in Cumulus cells and its relevance to infertility in endometriosis. ( 27167072 )
2016
31
Fitz-Hugh-Curtis syndrome: An incidental diagnostic finding in an infertility workup. ( 27811461 )
2016
32
Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility. ( 27651720 )
2016
33
Methionine synthase A2756G transition might be a risk factor for male infertility: Evidences from seven case-control studies. ( 26905524 )
2016
34
Re: The "Omics" of Human Male Infertility: Integrating Big Data in a Systems Biology Approach. ( 27628827 )
2016
35
Frequency of Y Chromosome Microdeletions Among Iranian Infertile Men with Azoospermia and Severe Oligozoospermia: A Meta-analysis. ( 27920999 )
2016
36
Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis. ( 27173242 )
2016
37
Association of G/T(rs222859) polymorphism in Exon 1 of YBX2 gene with azoospermia, among Iranian infertile males. ( 26804374 )
2016
38
The polymorphism G4C14-to-A4T14 in p73 gene may affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population. ( 27525684 )
2016
39
Oxidative stress and the etiology of male infertility. ( 27544275 )
2016
40
Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment. ( 28074124 )
2016
41
Current medical management of endocrine-related male infertility. ( 27072045 )
2016
42
Infertility in men with inflammatory bowel disease. ( 27602237 )
2016
43
Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest. ( 27545678 )
2016
44
Comparison of Serum Leptin Level in Women with Unexplained Infertility and Fertile Women in Iran. ( 27651647 )
2016
45
Genetics of Male Infertility. ( 27502429 )
2016
46
A Study on the Role of Estrogen Receptor Gene Polymorphisms in Female Infertility. ( 27574919 )
2016
47
Low-level environmental arsenic exposure correlates with unexplained male infertility risk. ( 27485131 )
2016
48
Large Scale 7436-bp Deletions in Human Sperm Mitochondrial DNA with Spermatozoa Dysfunction and Male Infertility. ( 28050401 )
2016
49
Asymptomatic Infection With Mycoplasma hominis Negatively Affects Semen Parameters and Leads to Male Infertility as Confirmed by Improved Semen Parameters After Antibiotic Treatment. ( 27871827 )
2016
50
Prevalence and Risk Factors of Infertility at a Rural Site of Northern China. ( 27177147 )
2016

Variations for Infertility

ClinVar genetic disease variations for Infertility:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NPHP4 NM_015102.4(NPHP4): c.2044C> T (p.Arg682Ter) single nucleotide variant Pathogenic/Likely pathogenic rs137852920 GRCh37 Chromosome 1, 5964776: 5964776

Copy number variations for Infertility from CNVD:

7 (show all 50)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion AZFb infertility
13 266750 Y 1 57772954 Microdeletion AZFc infertility
14 266796 Y 11300000 27200000 Deletion AZF infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZFa infertility
17 266827 Y 11300000 27200000 Microdeletion AZFb infertility
18 266828 Y 11300000 27200000 Microdeletion AZFc infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4LY infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion GOLGAZLY infertility
27 266840 Y 11300000 27200000 Microdeletion NAHR infertility
28 266841 Y 11300000 27200000 Microdeletion NOA infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF infertility
32 266975 Y 174481503 174538309 Microdeletions AZF infertility
33 266976 Y 174481503 174538309 Microdeletions AZFA infertility
34 267088 Y 23407118 25740308 Copy number TTTY17 Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4LY Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation ATPase6 Infertility
49 267527 mtDNA 1 16569 Mutation CYTB Infertility
50 267528 1 183532144 183553084 Mutation ND1 Infertility

Expression for Infertility

Search GEO for disease gene expression data for Infertility.

Pathways for Infertility

GO Terms for Infertility

Cellular components related to Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 EPPIN ESR2 FSHB GNRH1 INHA LEFTY2
2 secretory granule GO:0030141 8.8 PRL ZP2 ZP3

Biological processes related to Infertility according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 spermatogenesis GO:0007283 9.89 CATSPER2 DAZ1 DAZL DPY19L2 FSHR
2 female pregnancy GO:0007565 9.74 FSHB GNRH1 PRL
3 male gonad development GO:0008584 9.71 FSHR INHA LHCGR NR5A1
4 single fertilization GO:0007338 9.69 SPAG1 ZP2 ZP3
5 steroid hormone mediated signaling pathway GO:0043401 9.65 ESR2 NR5A1 PGR
6 cell-cell signaling GO:0007267 9.63 ESR2 FSHB GNRH1 INHA NR5A1 PGR
7 regulation of MAPK cascade GO:0043408 9.61 FSHR INHA LEFTY2
8 female gamete generation GO:0007292 9.59 FSHB FSHR
9 uterus development GO:0060065 9.58 CYP19A1 FSHR
10 positive regulation of translational initiation GO:0045948 9.58 DAZ1 DAZL
11 positive regulation of adenylate cyclase activity GO:0045762 9.55 FSHR LHCGR
12 manganese ion transport GO:0006828 9.54 ZP2 ZP3
13 ovulation cycle GO:0042698 9.52 GNRH1 PRL
14 female gonad development GO:0008585 9.5 CYP19A1 FSHR NR5A1
15 Sertoli cell proliferation GO:0060011 9.46 FSHB FSHR
16 regulation of osteoclast differentiation GO:0045670 9.43 FSHB FSHR LHCGR
17 primary ovarian follicle growth GO:0001545 9.37 FSHR LHCGR
18 hormone-mediated signaling pathway GO:0009755 9.26 FSHB FSHR LHCGR NR5A1
19 follicle-stimulating hormone signaling pathway GO:0042699 8.8 FSHB FSHR LHCGR
20 signal transduction GO:0007165 10.2 ESR2 FSHB FSHR GNRH1 INHA LHCGR
21 cell differentiation GO:0030154 10.03 CATSPER2 DAZ1 DAZL DPY19L2 INHA NR5A1

Molecular functions related to Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.54 ESR2 NR5A1 PGR
2 G-protein coupled peptide receptor activity GO:0008528 9.43 FSHR LHCGR
3 translation activator activity GO:0008494 9.4 DAZ1 DAZL
4 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.33 ESR2 NR5A1 PGR
5 protein-hormone receptor activity GO:0016500 9.32 FSHR LHCGR
6 acrosin binding GO:0032190 9.26 ZP2 ZP3
7 hormone activity GO:0005179 9.26 FSHB GNRH1 INHA PRL
8 follicle-stimulating hormone receptor activity GO:0004963 8.62 FSHR LHCGR

Sources for Infertility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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