MCID: INF032
MIFTS: 56

Infertility malady

Summaries for Infertility

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Sources:
33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Infertility means not being able to become pregnant after a year of trying. if a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. infertility is fairly common. after one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. about a third of the time, infertility can be traced to the woman. in another third of cases, it is because of the man. the rest of the time, it is because of both partners or no cause can be found. there are treatments that are specifically for men or for women. some involve both partners. drugs or surgery are common treatments. happily, many couples treated for infertility go on to have babies. nih: national institute of child health and human development

MalaCards: Infertility is related to male infertility and azoospermia. An important gene associated with Infertility is DDX3Y (DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked). The drugs bromocriptine and follitropin beta have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis.

CDC:3 In general, infertility is defined as not being able to get pregnant (conceive) after one year of unprotected sex. Women who do not have regular menstrual cycles, or are older than 35 years and have not conceived during a 6-month period of trying, should consider making an appointment with a reproductive endocrinologist—an infertility specialist. These doctors may also be able to help women with recurrent pregnancy loss—2 or more spontaneous miscarriages. Pregnancy is the result of a process that has many steps. To get pregnant—

Wikipedia:63 Infertility is fundamentally the inability to conceive offspring. Infertility also refers to the state... more...

Aliases & Classifications for Infertility

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Sources:
8Disease Ontology, 63Wikipedia, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

infertility 8 63 22 10 44 33 60


External Ids:

Disease Ontology8 DOID:5223
MeSH34 D007246
NCIt39 C3836

Related Diseases for Infertility

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1male infertility31.8DDX3Y, DAZL, USP26
2azoospermia31.0USP26, DDX3Y, DAZAP1, H2BFWT, DAZL
3y chromosome infertility30.6DDX3Y, HSFY1
4oligospermia30.6DDX3Y, DAZL
5sertoli cell-only syndrome30.2DDX3Y
6endometriosis10.8
7varicocele10.8
8polycystic ovary syndrome10.5
9cryptorchidism10.4
10anovulation10.4
11hypogonadism10.4
12salpingitis10.4
13obesity10.4
14peritonitis10.4
15hyperprolactinemia10.4
16thyroiditis10.4
17deafness-infertility syndrome10.4
18prostatitis10.4
19cystic fibrosis10.3
20cervicitis10.3
21pelvic inflammatory disease10.3
22leukemia10.3
23endometritis10.3
24catsper1-related nonsyndromic male infertility10.2
25congenital adrenal hyperplasia10.2
26hypogonadotropism10.2
27vaginitis10.2
2821-hydroxylase deficiency10.2
29klinefelter's syndrome10.2
30hyperandrogenism10.2
31hypothyroidism10.2
32testicular cancer10.2
33congenital absence of the vas deferens10.2
34spermatogenic failure 410.2
35female infertility of uterine origin10.2
36impotence10.2
37thrombophilia10.2
38amenorrhea10.1
39orchitis10.1
40catsper-related male infertility10.1
41myoma10.1
42renal agenesis10.1
43salpingitis isthmica nodosa10.1
44premature ovarian failure10.1
45infertility due to extratesticular cause10.1
46adenocarcinoma10.1
47endometrial adenocarcinoma10.1
48ovarian disease10.1
49tuberculosis10.1
50adrenal rest tumor10.0

Graphical network of the top 20 diseases related to Infertility:



Diseases related to infertility

Clinical Features for Infertility

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Drugs & Therapeutics for Infertility

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Infertility

Drug clinical trials:

Search ClinicalTrials for Infertility

Search NIH Clinical Center for Infertility

Search CenterWatch for Infertility

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Infertility

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Sources:
22GTR
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Genetic tests related to Infertility:

id Genetic test Affiliating Genes
1 Infertility22

Anatomical Context for Infertility

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Sources:
32MalaCards
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MalaCards organs/tissues related to Infertility:

32
Ovary, Testes, Testis, Thyroid, Prostate, Endothelial, Pituitary, Spinal cord, Bone, Uterus, Kidney, Breast, Eye, Nk cells, Colon, Liver, T cells, Monocytes, Skin, Heart, Hypothalamus

Animal Models for Infertility or affiliated genes

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Publications for Infertility

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Sources:
50PubMed
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Articles related to Infertility:

(show top 50)    (show all 2149)
idTitleAuthorsYear
1
Current management of male infertility. (24286779)
2014
2
The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility. (23415969)
2013
3
Mindfulness-Based Program for Infertility: efficacy study. (23809500)
2013
4
Wandering-and wondering-about the pharmacological management of human infertility. (23872987)
2013
5
4977-bp mitochondrial DNA deletion in infertile patients with varicocele. (23421634)
2013
6
Socio-cultural perspectives on causes and intervention strategies of male infertility: a case study of Mhondoro-Ngezi, Zimbabwe. (24069755)
2013
7
Management of infertility today. (24156984)
2013
8
Risk and safety management in infertility and assisted reproductive technology (ART): from the doctor's office to the ART procedure. (24200109)
2013
9
Adenomyosis within a uterine septum in a patient with secondary infertility. (23741967)
2013
10
Comparison of IVF/ICSI outcome in patients with polycystic ovarian syndrome or tubal factor infertility. (23563463)
2013
11
Polymorphisms in aryl hydrocarbon receptor gene are associated with idiopathic male factor infertility. (23703535)
2013
12
Optimising the management of patients with infertility. (23634635)
2013
13
Talking about links between sexually transmitted infections and infertility with college and university students from SE England, UK: a qualitative study. (24020982)
2013
14
Involvement of sperm plasma membrane and cytoskeletal proteins in human male infertility. (23174138)
2013
15
Frequency and patterns of abnormal Pap smears in Sudanese women with infertility: What are the perspectives? (23833398)
2013
16
Focus issue on male infertility. (22190920)
2012
17
Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility. (22926843)
2012
18
Surgical techniques for the management of male infertility. (22120932)
2012
19
Unexplained infertility: association with inherited thrombophilia. (22425217)
2012
20
Effects of prostaglandin E2 and vascular endothelial growth factor on sperm might lead to endometriosis-associated infertility. (20864099)
2011
21
Alterations in endometrial vascular density via hysteroscopy evaluated by vascular analysis software during laparoscopic myomectomy on an infertile woman with submucous myoma. (21155634)
2011
22
Hyperprolactinemia and infertility. (22108283)
2011
23
Genetic variation of hormone sensitive lipase and male infertility. (21919688)
2011
24
Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion. (20576090)
2010
25
The role of endothelial nitric oxide synthase (eNOS) T-786C, G894T, and 4a/b gene polymorphisms in the risk of idiopathic male infertility. (20586099)
2010
26
Anticardiolipin antibodies in pathogenesis of infertility. (20361696)
2010
27
Eurycoma longifolia Jack in managing idiopathic male infertility. (20348942)
2010
28
Improvement of semen quality in an infertile man with 21-hydroxylase deficiency, suppressed serum gonadotropins and testicular adrenal rest tumours. (19281490)
2010
29
Male infertility associated with adult dominant polycystic kidney disease: a case series. (19137444)
2009
30
Influence of polymorphism of glutathione S-transferase T1 on Chinese infertile patients with varicocele. (18163994)
2009
31
Cystathionine B-Synthase 844ins68 Gene Variant and Idiopathic Male Infertility. (19657138)
2009
32
Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique. (18772487)
2009
33
Endometrial mRNA expression of matrix metalloproteinases, their tissue inhibitors and cell adhesion molecules in unexplained infertility and implantation failure patients. (19778485)
2009
34
Novel variants in UBE2B gene and idiopathic male infertility. (18497339)
2008
35
Infertility, bilateral multicystic serous cystadenoma and pregnancy. (18682003)
2008
36
Serum leptin correlates in infertile oligozoospermic males. (17714215)
2007
37
Leukaemia inhibitory factor and interleukin 11 levels in uterine flushings of infertile patients with endometriosis. (17000646)
2006
38
Evaluation of DAZ microdeletions in 34 infertile men. (16574598)
2006
39
Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. (15340058)
2004
40
Cystic fibrosis as a cause of infertility. (15297887)
2004
41
Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (15044259)
2004
42
Genetic analysis of three polymorphic sites of the luteinizing hormone beta-subunit gene in infertile Korean men with nonobstructive azoospermia. (12620433)
2003
43
Abnormal expression of acid glycosidases in seminal plasma and spermatozoa from infertile men with varicocele. (11882018)
2002
44
Relationship between seminal plasma interleukin-6 and tumor necrosis factor alpha levels with semen parameters in fertile and infertile men. (12202945)
2002
45
Vitamin B12 deficiency, infertility and recurrent fetal loss. (11304860)
2001
46
Secondary infertility as early symptom in a man with multiple endocrine neoplasia-type 1. (10374130)
1999
47
Y-autosome translocation and infertility: usefulness of molecular, cytogenetic and meiotic studies. (9490306)
1998
48
Preserved pituitary response under ovarian stimulation with HMG and GnRH antagonists (Cetrorelix) in women with tubal infertility. (7556837)
1995
49
Corticoid therapy of infertility associated with anovulation and elevated 17-ketosteroids. (14036160)
1961
50
Diagnosis and treatment of infertility due to anovulation. (21025738)
1946

Genetic Variations for Infertility

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Expression for genes affiliated with Infertility

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Infertility

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Pathways for genes affiliated with Infertility

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Compounds for genes affiliated with Infertility

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GO Terms for genes affiliated with Infertility

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16Gene Ontology
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Biological processes related to Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:00733810.8SPAG1, BPY2C
2spermatogenesisGO:00728310.8DAZL, DAZAP1, MORC1, BPY2C

Products for genes affiliated with Infertility

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Sources for Infertility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet