Infertility malady

MedlinePlus: Infertility means not being able to become pregnant after a year of trying. if a woman keeps having miscarriages, it is also called infertility. lots of couples have infertility problems. about a third of the time, infertility can be traced to the woman. in another third of cases, it is because of the man. the rest of the time, it is because of both partners or no cause is found. drugs or surgery are common treatments. happily, two-thirds of couples treated for infertility go on to have babies. dept. of health and human services office on women's health²³

MalaCards: Infertility is related to male infertility and azoospermia. An important gene associated with Infertility is SPAG1 (sperm associated antigen 1), and among its related pathways are ERK Signaling and Glutathione metabolism. The drugs follitropin beta and follitropin alfa and the compounds alanine and cysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and thyroid, and related mouse phenotypes are digestive/alimentary and reproductive system.

CDC: Infertility means not being able to get pregnant after one year of trying. Or, six months, if a woman is 35 years of age or older. Women who can get pregnant but are unable to stay pregnant may also be infertile.²

Wikipedia: Infertility primarily refers to the biological inability of a person to contribute to conception....⁴⁴ more...

Aliases & Descriptions:

infertility 6 44 17 8 32 23 43

Diseases related to infertility by text searches and GeneDecks gene sharing:

(show top 50)    (show all 994)

id	Related Disease	Score	Top Affiliating Genes
1	male infertility	46.7	KITLG, RBMY1A1, SEMG1, BOLL, USP26, USP9Y
2	azoospermia	44.7	KLHL10, REC8, KIT, RBMY1A1, BRCA2, BPY2
3	carcinoma	42.8	ZNF148, PIP, PIK3C2A, NCEH1, NCOA2, CNC
4	prostatitis	41.7	PIP, PIK3C2A, NCOA2, SGK1, KIT, KITLG
5	endometriosis	41.5	KIR2DL1, KIR2DL3, KITLG, PCSK5, GC, SEMA3C
6	leukemia	40.8	PIK3C2A, NCOA2, KIT, KIR2DL1, KIR2DL3, KITLG
7	cryptorchidism	36.1	USP9Y, LEP, CGA, CGB5, AZF1, KAL1
8	thyroiditis	36.0	PIK3C2A, NCOA2, CNC, KIT, KITLG, PCSK5
9	varicocele	35.9	USP9Y, BLVRB, CKM, LDHC, XDH, CGA
10	polycystic ovary syndrome	34.9	LHCGR, LEP, CGA, CGB5, FSHR, FST
11	oligospermia	34.3	KLHL10, RBMY1A1, USP9Y, AZF1, CFTR, AR
12	y chromosome infertility	33.9	RBMY1A1, USP9Y, CDY1, HSFY1, DDX3Y, DAZ1
13	ovarian cancer	33.8	NCOA2, SGK1, KIT, KITLG, SERPINA6, SERPINA1
14	epididymitis	33.8	SERPINA1, SERPING1, CLU, CKM, CGB5, CFTR
15	adrenal hyperplasia	33.4	CNC, LEP, CGA, CGB, CGB5, AR
16	hypogonadism	33.2	GC, SERPINA6, SERPINE1, USP26, CLU, LHB
17	melanoma	33.0	PIK3C2A, NCEH1, NCOA2, CNC, KIT, KIR2DL1
18	obesity	32.8	PIK3C2A, SGK1, KIR2DL1, KIR2DL3, GC, SERPINA6
19	spontaneous abortion	32.7	KIR2DL1, KIR2DL3, SERPINE1, VEGFA, PAEP, PAPPA
20	klinefelter's syndrome	32.6	SERPINE1, USP9Y, LEP, MTHFR, CGA, CGB
21	peritonitis	32.4	PIK3C2A, SGK1, KIT, KIR2DL1, KIR2DL3, KITLG
22	21-hydroxylase deficiency	32.1	GNRH1, HSD3B2, CYP11A1, CYP17A1, CYP19A1, CYP21A2
23	hypogonadotropism	32.0	LHB, LHCGR, LEP, LEPR, CGA, CGB5
24	fibrosis	32.0	SGK1, KIT, KITLG, KIF16B, GC, SERPINA1
25	amenorrhea	32.0	BMP15, LHB, LHCGR, LEP, CGA, FSHB
26	turner syndrome	31.8	BMP15, PAEP, PAPPA, XDH, CGA, CGB
27	hyperandrogenism	31.7	LHCGR, LEP, CGA, CGB5, FSHR, AR
28	virilization	31.5	LHCGR, LEP, CGA, CGB5, AZF1, FSHB
29	cervicitis	31.5	KIT, KIR2DL1, KIR2DL3, KITLG, GC, SERPINA1
30	anovulation	31.2	BMP15, LEP, CGA, FSHB, FSHR, INS
31	hypothyroidism	31.1	LEP, CETP, APOB, IGFBP3, GHRL, TRH
32	hyperprolactinemia	31.1	CGA, CGB, CGB5, INS, IL4, IL6
33	gonadal dysgenesis	30.8	BMP15, XDH, CGB, CGB5, AZF1, FSHR
34	testicular cancer	30.5	SERPINE1, BMP6, USP9Y, XPC, CGA, CGB
35	cystic fibrosis	30.4	SGK1, GC, SERPINA1, BRCA1, VEGFA, VDAC1
36	sertoli cell-only syndrome	30.3	ZNF148, UTY, USP9Y, AZF1, FSHR, CASP3
37	endometritis	30.3	VEGFA, PAEP, CGA, IL6, IGFBP1, HOXA10
38	thrombophilia	30.2	SERPINE1, MTRR, MTHFR, CETP, ITGA3, ITGB3
39	breast cancer	30.2	PIP, NCOA2, SGK1, BRCA1, BRCA2, BMP6
40	cholesterol	29.9	PIK3C2A, NCEH1, NCOA2, SGK1, KITLG, PCSK5
41	down syndrome	29.7	KITLG, SERPINE1, VEGFA, BMP6, CLU, PAPPA
42	androgen insensitivity syndrome	29.5	NCOA2, S100A6, CGA, AR, INHA, INS
43	gonadotropin deficiency	29.4	CGA, KAL1, FSHR, GNRH1, GNRHR, GH1
44	hereditary leiomyomatosis and renal cell cancer	29.3	VEGFA, PAEP, BCL2, BAX, FH, GSTM1
45	fragile x-associated primary ovarian insufficiency	29.2	CGA, FSHR, INSR, IGFBP1, GNRH1, CYP19A1
46	cryptorchidism, idiopathic	29.1	AZF1, INSL3, DAZ1, DAZ2, DAZ3, DAZ4
47	leiomyoma	29.1	KIT, SERPINE1, BRCA1, BRCA2, VEGFA, BMP6
48	vaginitis	29.0	PIK3C2A, KIT, GC, SERPINA6, SERPINE1, LIF
49	globozoospermia	29.0	PICK1, GOPC, SPATA16, ACR, DPY19L2, CSNK2A2
50	ovarian hyperstimulation syndrome	28.8	VEGFA, BMP15, LHCGR, LEP, MTHFR, CGA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bromocriptine, bromocriptine mesylate, follitropin, follitropin alfa, follitropin beta, leuprolide, leuprolide acetate, sermorelin, sermorelin acetate

MalaCards organs/tissues related to infertility:

²²

MGI Mouse Phenotypes related to infertility:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary phenotype	MP:0005381	INF	ZNF148, KIT, KITLG, PCSK5, BRCA1, BRCA2
2	reproductive system phenotype	MP:0005389	INF	ZNF148, PICK1, KLHL10, NCOA2, REC8, SERPINA5
3	growth/size phenotype	MP:0005378	INF	ZNF148, PIK3C2A, NCOA2, REC8, SGK1, KIT
4	renal/urinary system phenotype	MP:0005367	INF	SGK1, KIT, PCSK5, SERPINA6, BRCA1, LIMK2
5	liver/biliary system phenotype	MP:0005370	INF	KIT, SERPINA6, SEPP1, VEGFA, LIF, LIPE
6	hematopoietic system phenotype	MP:0005397	INF	KIT, BRCA1, BRCA2, BCL2, LEFTY2, XPA
7	nervous system phenotype	MP:0003631	INF	ZNF148, PICK1, KIT, KITLG, PCSK5, SEMA3C
8	normal phenotype	MP:0002873	INF	ZNF148, SERPING1, BRCA1, BRCA2, VEGFA, BDNF
9	behavior/neurological phenotype	MP:0005386	INF	NCOA2, KIT, SERPINA6, SEPP1, BRCA2, VDAC1
10	integument phenotype	MP:0010771	12.4	ZNF148, NCOA2, KIT, KITLG, BRCA1, BRCA2
11	no phenotypic analysis	MP:0003012	11.6	NCOA2, SGK1, PCSK5, SERPINA6, VEGFA, LIMK2
12	tumorigenesis	MP:0002006	11.4	KIT, KITLG, SERPINE1, BRCA1, BRCA2, BCL2
13	pigmentation phenotype	MP:0001186	10.6	KIT, KITLG, SEMA3C, BRCA1, BCL2, XPA
14	other phenotype	MP:0005395	10.5	CLU, LEPR, LAMC1, FSHR, ITGB1, ITGB3
15	adipose tissue phenotype	MP:0005375	10.2	PIK3C2A, SERPINE1, BRCA1, LIF, LIPE, BCL2
16	muscle phenotype	MP:0005369	10.1	KIT, BRCA1, VEGFA, VDAC3, LIF, LIPE
17	cellular phenotype	MP:0005384	INF	ZNF148, PICK1, NCEH1, KIT, KITLG, SEMA3C
18	cardiovascular system phenotype	MP:0005385	INF	ZNF148, NCEH1, KIT, KITLG, PCSK5, SEMA3C
19	vision/eye phenotype	MP:0005391	INF	KIT, KITLG, VEGFA, LIF, BDNF, BCL2
20	endocrine/exocrine gland phenotype	MP:0005379	INF	ZNF148, PICK1, KLHL10, NCOA2, REC8, SERPINA5
21	immune system phenotype	MP:0005387	INF	ZNF148, NCEH1, NCOA2, KIT, PCSK5, SERPINA6
22	respiratory system phenotype	MP:0005388	INF	PCSK5, BRCA1, VDAC3, LIF, BDNF, LEFTY1
23	skeleton phenotype	MP:0005390	INF	KIT, KITLG, PCSK5, GC, BRCA1, BRCA2
24	limbs/digits/tail phenotype	MP:0005371	INF	KIT, KITLG, PCSK5, SEPP1, BRCA1, BRCA2
25	craniofacial phenotype	MP:0005382	INF	KIT, KITLG, PCSK5, PAX8, BDNF, XPA
26	homeostasis/metabolism phenotype	MP:0005376	INF	ZNF148, PIK3C2A, NCEH1, SGK1, KIT, KITLG
27	mortality/aging	MP:0010768	INF	ZNF148, PIK3C2A, REC8, KITLG, KIF16B, PCSK5
28	hearing/vestibular/ear phenotype	MP:0005377	INF	KIT, KITLG, PAX8, BDNF, BCL2, BAX
29	embryogenesis phenotype	MP:0005380	INF	ZNF148, NCOA2, KIT, KIF16B, SEMA3C, BRCA1

Articles related to infertility:

(show top 50)    (show all 861)

id	Title	Authors	Year	Affiliating Genes
1	SEPT12 mutations cause male infertility with defective sperm annulus. (22275165)	Kuo Y.C.... Kuo P.L.	2012	SEPT12
2	Promoter -817C>T variant of B lymphocyte stimulato r gene (BLyS) and susceptibility to endometriosis-related infertility and idiop athic infertility in Brazilian population. (21883351)	Christofolini D.M.... Barbosa C.P.	2011	TNFSF13B
3	Assessment of an association between an aryl hydrocar bon receptor gene (AHR) polymorphism and risk of male infertility. (21613234)	Gu A.... Wang X.	2011	AHR
4	Association of FCRL3 C-169T promoter single-nucleotid e polymorphism with idiopathic infertility and infertility-related endometriosi s. (21529967)	Teles J.S.... Barbosa C.P.	2011	FCRL3
5	Polymorphism of the estrogen receptor I^ gene is relat ed to infertility and infertility-associated endometriosis. (20857063)	Zulli K.... Barbosa C.P.	2010	ESR2
6	Luteinizing hormone beta-subunit gene (LHbeta) polymo rphism in infertility and endometriosis-associated infertility. (20430510)	Mafra F.A.... Barbosa C.P.	2010	LHB
7	Effects of race/ethnicity on triple CGG counts in the FMR1 gene in infertile women and egg donors. (20149747)	Gleicher N.... Barad D.H.	2010	FMR1
8	Frequency distribution of polymorphisms in the FSH re ceptor gene in infertility patients of different ethnicity. (20223709)	Kuijper E.A.... Lambalk C.B.	2010	FSHR
9	The progins progesterone receptor gene polymorphism i s not related to endometriosis-associated infertility or to idiopathic infertil ity. (21243274)	Gimenes C.... Barbosa C.P.	2010	PGR
10	Spermatozoal protein profiles in male infertility with asthenozoospermia. (21034600)	Li H.J.... Li H.Z.	2010	DDX4
11	HOXA-10 expression in the mid-secretory endometrium o f infertile patients with either endometriosis, uterine fibromas or unexplained infertility. (19736237)	Matsuzaki S.... Mage G.	2009	HOXA10
12	Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities. (18439585)	Veaute C.... Vazquez-Levin M.H.	2009	ACR
13	Lack of varied endometrial expression of proprotein c onvertase 6 in infertile women with minimal grade endometriosis and idiopathic infertility. (19642596)	MikoA8ajczyk M.... Skrzypczak J.	2009	PCSK5
14	Inherited thrombophilia in infertile women-implicatio n in unexplained infertility. (19939360)	Casadei L.... Emidi E.	2009	F2, F5, MTHFR
15	Effect of cigarette smoking on antioxidant levels and presence of leukocytospermia in infertile men: a prospective study. (18462724)	Pasqualotto F.F.... Pasqualotto E.B.	2008	SOD1
16	A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister. (18508780)	Bruysters M.... Bouchard P.	2008	LHCGR
17	Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms. (17932109)	Lin S.Y.... de Kretser D.M.	2008	FST
18	Structured exercise training programme versus hypocal oric hyperproteic diet in obese polycystic ovary syndrome patients with anovula tory infertility: a 24-week pilot study. (18158291)	Palomba S.... Orio F.	2008	INS
19	Treatment of unexplained infertility with aromatase inhibitors or clomiphene citrate: a systematic review and meta-analysis. (18559123)	Polyzos N.P.... Casazza G.	2008	CYP19A1
20	Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study. (18509731)	Kotsopoulos J.... Narod S.A.	2008	BRCA1, BRCA2
21	Primary male infertility in Kuwait: a cytogenetic and molecular study of 289 infertile Kuwaiti patients. (17683468)	Mohammed F.... Naguib K.K.	2007	AZF1
22	Relationship between contents of lipocalin-type prostaglandin D synthase on the surface of infertility sperm and in seminal plasma. (17367300)	Chen D.Y.... Huang T.H.	2007	PTGDS
23	Serum leptin level in women with unexplained infertility. (17485120)	Demir B.... Gul T.	2007	LEP, LSL
24	The leukemia inhibitory factor gene mutations in the population of infertile women: the heterozygote transition G to A on the position 3400 does not affect the outcome of the infertility treatment (17966612)	Kralickova M.... Hes O.	2007	LIF
25	Analysis of the hemochromatosis mutations C282Y and H63D in infertile men. (17067586)	Peterlin B.... Zorn B.	2006	HFE
26	Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients. (16269446)	Bedaiwy M.A.... Agarwal A.	2006	LEP
27	Leukaemia inhibitory factor and interleukin 11 levels in uterine flushings of infertile patients with endometriosis. (17000646)	Mikolajczyk M.... Skrzypczak J.	2006	LIF, IL11
28	Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. (16478764)	Sohrabvand F.... Bagheri M.	2006	CYP19A1, CGA
29	Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility. (16123080)	Yang X.J.... Nakahori Y.	2005	DAZL, DAZ1
30	The clinical significance of the POLG gene polymorphism in male infertility. (15356024)	Krausz C.... Forti G.	2004	POLG
31	No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population. (15520024)	Tschanter P.... Gromoll J.	2004	DAZL, BOLL
32	Re: 'Is it necessary to obtain serum levels of thyroid stimulating hormone and prolactin in asymptomatic women with infertility?'. (15058510)	Raber W.... Vierhapper H.	2004	PRL
33	Reduced expression of alphavbeta3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures: improvement by danazol treatment. (12645863)	Tei C.... Yoshimura Y.	2003	ITGAV, ITGB3
34	CAG repeat length in the androgen receptor gene affects the risk of male infertility. (14511213)	Asatiani K.... Nieschlag E.	2003	AR
35	Detection and clinical significance of phospholipase A2 in semen of male infertile patients (12749123)	Wang S.K.... Wang Z.Z.	2003	PLA2G6
36	The management of infertility associated with polycystic ovary syndrome. (14617367)	Homburg R.	2003	CYP19A1, INS
37	Xylosyltransferase activity in seminal plasma of infertile men. (11814476)	Goetting C.... Kleesiek K.	2002	XYLT2, XYLT1
38	Implantation defects in infertile women with endometriosis. (11949954)	Lessey B.A.	2002	SPP1
39	Association of oestrogen receptor alpha polymorphisms and androgen receptor CAG trinucleotide repeats with male infertility: a study in 109 Greek infertile men. (12031042)	Kukuvitis A.... Papadimas J.	2002	AR, ESR1
40	Sex, infertility and the molecular biology of the androgen receptor. (11396657)	Loy C.J.... Yong E.L.	2001	AR
41	Effect of glycemia status on endocrinological parameters of impotent and infertile patients. (11505813)	Yilmaz E.... Kupeli S.	2001	PRL
42	Autoimmunity in endometriosis: relevance to infertility. (10994636)	Mathur S.P.	2000	AHSG
43	Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60 kDa heat shock protein (hsp60) in infertile couples and its relationship to antibodies to C.trachomatis surface antigens and the Escherichia coli and human HSP60. (9647542)	Witkin S.S.... Sarjdine K.	1998	HSPD1
44	Follitropin (FSH) deficiency in an infertile male due to FSHbeta gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations. (9806482)	Lindstedt G.... Chatterjee K.	1998	FSHB
45	Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. (9801113)	Segenreich E.... Livne P.	1998	GNRH1
46	Genetics of idiopathic male infertility: Y chromosomal azoospermia factors (AZFa, AZFb, AZFc). (9692017)	Vogt P.H.	1997	AZF1
47	Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. (7850869)	Bockers T.M.... Bergmann M.	1994	FSHB
48	Characterization of a human antigen with sera from infertile patients. (8025165)	Diekman A.B.... Goldberg E.	1994	UAP1
49	Routine hormone load tests are unnecessary in infertile men. (1322641)	Gerhard I.... Runnebaum B.	1992	PRL
50	Semen characteristics and diabetes mellitus: signific ance of insulin in male infertility. (1903630)	GarcA-a-DA-ez L.C.... Miralles J.M.	1991	PRL

Genes related to infertility according to GeneCards:

(show top 50)    (show all 515)

id	Symbol	Description	Score	GeneCards Section Context
1	SPAG1	sperm associated antigen 1	11.1	Summaries, Publications, Orthologs, Aliases & Descriptions
2	SPAG6	sperm associated antigen 6	11.1	Publications, Summaries
3	SPACA1	sperm acrosome associated 1	11.0	Summaries, Publications
4	DAZAP1	DAZ associated protein 1	11.0	Publications, Summaries
5	DEL15Q15.3	Deafness and male infertility	11.0	Aliases & Descriptions
6	DAZL	deleted in azoospermia-like	11.0	Publications, Summaries
7	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	11.0	Orthologs, Publications, Summaries
8	HSFY1	heat shock transcription factor, Y-linked 1	11.0	Summaries, Publications
9	USP26	ubiquitin specific peptidase 26	11.0	Summaries, Publications
10	BPY2	basic charge, Y-linked, 2	11.0	Publications, Summaries
11	BPY2C	basic charge, Y-linked, 2C	11.0	Summaries, Publications
12	BPY2B	basic charge, Y-linked, 2B	11.0	Summaries, Publications
13	HSFY2	heat shock transcription factor, Y linked 2	11.0	Summaries, Publications
14	LHB	luteinizing hormone beta polypeptide	11.0	Publications, Summaries
15	OAZ3	ornithine decarboxylase antizyme 3	11.0	Summaries, Publications
16	LEFTY2	left-right determination factor 2	11.0	Publications, Summaries
17	RBMXL2	RNA binding motif protein, X-linked-like 2	11.0	Summaries
18	SPAG4	sperm associated antigen 4	11.0	Summaries
19	H2BFWT	H2B histone family, member W, testis-specific	11.0	Publications, Summaries
20	TBPL1	TBP-like 1	11.0	Summaries, Publications
21	ODF1	outer dense fiber of sperm tails 1	11.0	Summaries
22	CLGN	calmegin	11.0	Summaries
23	DPY19L2	dpy-19-like 2 (C. elegans)	11.0	Summaries, Publications
24	NT5C1B	5'-nucleotidase, cytosolic IB	11.0	Publications, Aliases & Descriptions
25	EPPIN	epididymal peptidase inhibitor	11.0	Summaries, Publications
26	ASIP	agouti signaling protein	11.0	Summaries
27	GOPC	golgi-associated PDZ and coiled-coil motif containing	11.0	Summaries
28	SPAG8	sperm associated antigen 8	11.0	Summaries
29	MORC1	MORC family CW-type zinc finger 1	11.0	Summaries
30	DAZ1	deleted in azoospermia 1	11.0	UniProt Related, Publications
31	USP9Y	ubiquitin specific peptidase 9, Y-linked	11.0	Publications
32	ACR	acrosin	11.0	Publications
33	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
34	FSHR	follicle stimulating hormone receptor	11.0	Publications
35	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
36	ODF2	outer dense fiber of sperm tails 2	11.0	Summaries
37	CDYL	chromodomain protein, Y-like	11.0	Summaries
38	AZF1	azoospermia factor 1	11.0	Publications
39	PRM1	protamine 1	11.0	Publications
40	DAZ4	deleted in azoospermia 4	11.0	Publications, UniProt Related
41	PRM2	protamine 2	11.0	Publications
42	TNP2	transition protein 2 (during histone to protamine replacement)	11.0	Publications
43	STRC	stereocilin	11.0	Publications
44	TNP1	transition protein 1 (during histone to protamine replacement)	11.0	Publications
45	CATSPER2	cation channel, sperm associated 2	11.0	Publications, Disorders
46	RBMY1A1	RNA binding motif protein, Y-linked, family 1, member A1	11.0	Publications
47	AURKC	aurora kinase C	11.0	Publications
48	GPX4	glutathione peroxidase 4	11.0	Publications
49	POLG	polymerase (DNA directed), gamma	11.0	Publications
50	SRY	sex determining region Y	11.0	Publications

Pathways related to infertility according to GeneDecks:

(show top 50)    (show all 119)

id	Pathway	Score	Top Affiliating Genes
1	ERK Signaling36	11.7	PIP, KIT, KITLG, BMP15, BMP6, LIFR
2	Glutathione metabolism10	11.6	GSR, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5
3	RAR-Gamma-RXR-Alpha Degradation36	11.4	PIP, BMP15, LIF, IL11, IL15, IL23A
4	Akt Signaling36	11.3	PIP, KIT, BMP15, LIF, LIFR, LHB
5	Glutathione metabolism41	11.2	GSR, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5
6	Molecular Mechanisms of Cancer36	11.2	PIP, KITLG, BRCA1, BMP15, BMP6, LIF
7	Selected targets of GCR-alpha10	10.8	KITLG, LEP, CGA, FSHB, INS, INSR
8	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	10.8	XDH, MLH1, CAT, ERCC2, NQO1, NOS3
9	Doxorubicin Pathway, Pharmacokinetics34	10.8	XDH, CAT, AKR1A1, NQO1, NOS1, NOS2
10	Cytokine-cytokine receptor interaction20	10.8	KIT, KITLG, VEGFA, LIF, LIFR, LEP
11	Rho Family GTPases36	10.7	PIP, KIT, KITLG, BMP15, BMP6, LIF
12	PPAR Pathway36	10.7	KIT, KITLG, LHB, ITGA1, ITGA3, ITGAV
13	Pathways in cancer20	10.7	BRCA2, VEGFA, BIRC5, PAX8, BCL2, BAX
14	Antioxidant Action of Vitamin-C36	10.7	PIP, KIT, KITLG, BMP15, BMP6, LIF
15	Mitochondrial Apoptosis36	10.7	KIT, KITLG, VDAC1, VDAC3, BMP6, BDNF
16	Pancreatic Adenocarcinoma36	10.7	KIT, KITLG, BRCA2, BMP6, LIFR, BIRC5
17	Endothelin-1 Signaling Pathway36	10.6	PIP, KIT, BMP15, BMP6, LIFR, INSR
18	Hematopoietic cell lineage20	10.6	KIT, KITLG, CD44, CD9, ITGA1, ITGA3
19	Glioma Invasiveness36	10.5	KITLG, BMP6, BDNF, LHB, CD44, ITGA1
20	MAPK Signaling36	10.5	KIT, KITLG, BMP6, LIFR, BDNF, BCL2
21	DHA Signaling36	10.5	KIT, KITLG, BMP6, BDNF, BCL2, LHB
22	p53 Mediated Apoptosis36	10.5	KIT, KITLG, BMP6, BDNF, BCL2, LHB
23	Cellular Apoptosis Pathway36	10.4	KIT, KITLG, VDAC1, VDAC3, BMP6, BDNF
24	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	10.3	CGA, AR, IL1A, IL1B, IL6, APOE
25	PAK Pathway36	10.3	PIP, KIT, KITLG, BMP15, BMP6, LIF
26	Transcription Role of VDR in regulation of genes involved in osteoporosis10	10.3	CGA, AR, IL1A, IL1B, IL6, APOE
27	Amoebiasis20	10.3	LAMA1, LAMB1, LAMC1, FN1, IL1B, IL1R2
28	IL-6 Pathway36	10.3	PIP, BMP15, BMP6, LIF, BCL2, BAX
29	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	IL17A, IL1B, IL23A, IL4, IL6, IL6R
30	MIF Mediated Glucocorticoid Regulation36	10.3	PIP, BMP15, BMP6, LIF, BCL2, BAX
31	MIF Regulation of Innate Immune Cells36	10.3	PIP, BMP15, BMP6, LIF, BCL2, BAX
32	STAT3 Pathway36	10.2	PIP, BMP15, BMP6, LIF, LIFR, BCL2
33	all-trans-Retinoic Acid Signaling in Brain36	10.2	PIP, BMP15, BMP6, LIF, BCL2, BAX
34	p38 Signaling36	10.1	PIP, KIT, KITLG, BMP15, BMP6, LIF
35	Complement and coagulation cascades20	10.0	SERPINA5, SERPINA1, SERPINE1, SERPING1, CFI, CD46
36	Pertussis20	10.0	SERPING1, ITGB1, IL10, IL1A, IL1B, IL23A
37	TGF-Beta Pathway36	10.0	KITLG, BMP15, BMP6, BDNF, BCL2, LHB
38	Toxoplasmosis20	9.9	BCL2, LAMA1, LAMB1, LAMC1, ITGB1, IL10
39	MAPK Family Pathway36	9.9	KITLG, BMP15, BMP6, BDNF, BCL2, LHB
40	PEDF Induced Signaling36	9.9	PIP, BMP15, BMP6, LIF, BDNF, BCL2
41	PGC1Alpha Pathway36	9.8	BMP15, BMP6, BCL2, BAX, INSR, IL11
42	Tec Kinases Signaling36	9.8	KITLG, BMP15, BMP6, LIFR, BDNF, BCL2
43	SOCS Pathway36	9.7	BMP15, BMP6, BCL2, UBE2B, BAX, INS
44	Chagas disease (American trypanosomiasis)20	9.7	SERPINE1, IL10, IL1B, IL6, IL8, FAS
45	Cell adhesion ECM remodeling10	9.7	SERPINE1, LAMA1, LAMB1, LAMC1, CD44, ITGA1
46	Cell adhesion_ECM remodeling41	9.7	SERPINE1, LAMA1, LAMB1, LAMC1, CD44, ITGA1
47	Rheumatoid arthritis20	9.6	VEGFA, IL11, IL15, IL17A, IL1A, IL1B
48	JAK-STAT Pathway36	9.6	KIT, KITLG, BRCA1, BMP15, BMP6, LIFR
49	Leishmaniasis20	9.5	ITGB1, FCGR3A, IL10, IL1A, IL1B, IL4
50	Tuberculosis20	9.3	BCL2, BAX, FCGR3A, IL10, IL1A, IL1B

Compounds related to infertility according to GeneDecks:

(show top 50)    (show all 532)

id	Compound	Score	Top Affiliating Genes
1	alanine32	INF	PIK3C2A, KITLG, SERPINA6, SERPING1, BRCA1, BMP6
2	cysteine32	INF	SERPINA6, SERPINA1, SEPP1, BRCA1, VDAC1, LIF
3	oxygen32 18	INF	PIK3C2A, KITLG, SERPINA1, SEPP1, BRCA1, VDAC1
4	atp32	14.0	PIK3C2A, KIT, KIF16B, BRCA1, VDAC1, LIF
5	cyclic amp32 18	14.1	NCOA2, SGK1, CNC, LIF, LIPE, BDNF
6	acth32	12.9	PIK3C2A, SERPINA6, SERPINA1, LIFR, BDNF, LHCGR
7	ethanol32 34 9 18 9	16.2	KITLG, SERPINA1, LIPE, BLVRB, CLU, BDNF
8	cholesterol32 9 18 9	14.7	PIK3C2A, NCOA2, KITLG, GC, SERPINA6, SERPINA1
9	norepinephrine32 9 18 9	14.6	PIK3C2A, KITLG, BMP6, LIF, LIPE, BDNF
10	uric acid32 18	12.4	PIK3C2A, SERPINE1, LEP, CHKA, MTHFR, XDH
11	heparin32 9 18 9	14.4	PIK3C2A, KITLG, SERPINA5, SERPINA1, SEPP1, SERPINE1
12	phosphatidylcholine32	11.4	VDAC1, LIPE, SCARB1, CHKA, CETP, ITGB1
13	epinephrine32 9 18 9	14.3	PIK3C2A, KITLG, BMP6, LIPE, BDNF, LEP
14	endotoxin32	11.3	GC, LIF, BLVRB, LEPR, ITGB1, MIF
15	etoposide32 42 9 9	14.2	BIRC5, CLU, BCL2, BAX, XRCC1, CGA
16	egcg32	11.2	IL1A, APP, CCL5, IGFBP3, CAT, CASP14
17	fibrinogen32	11.1	PIP, PIK3C2A, GC, SERPINA5, SERPINA1, SERPINE1
18	isoproterenol32 9 9	13.1	LIF, LIPE, LHCGR, UCP2, CGB5, CFTR
19	thymidylate32	11.0	BRCA1, VEGFA, BIRC5, BCL2, BAX, MTRR
20	nifedipine32 9 9	12.8	SERPINE1, BMP6, BDNF, LEP, CGB5, IL1A
21	metformin32 34 9 9	13.7	SERPINE1, LEP, MTHFR, CGA, INS, INSR
22	polyethylene glycol32	10.7	KITLG, VDAC1, MUC1, CD9, CDH1, FOLR1
23	paclitaxel32 34 9 9	13.7	KIT, KITLG, BRCA1, BRCA2, VEGFA, BMP6
24	acetylcholine32 9 18 9	13.6	PIK3C2A, BMP6, LIF, BLVRB, BDNF, LEP
25	levonorgestrel32 9 9	12.5	SERPINA6, PAEP, AR, APOA1, APOB, IGFBP1
26	pioglitazone32 9 9	12.4	VEGFA, LEP, FN1, INS, INSR, GSR
27	carboplatin32 34 9 9	13.4	KITLG, BRCA1, VEGFA, LIF, BCL2, MTHFR
28	s-nitroso-n-acetylpenicillamine32	10.4	XDH, FN1, IL1B, IL8, IFNG, CASP3
29	homocysteine32 18	11.4	PIK3C2A, SERPINE1, MTRR, MTR, CETP, FOLR1
30	bleomycin32 9 9	12.4	BRCA1, BRCA2, XRCC1, CGB, CD44, GSTM1
31	hydrocortisone32 9 9	12.3	KITLG, SERPINA6, BMP6, LIF, MUC1, MIF
32	tgf beta132	10.0	KITLG, SERPINE1, BMP6, LIF, FST, CDH1
33	curcumin32	9.6	VEGFA, BIRC5, BCL2, BAX, CFTR, CDH1
34	atorvastatin32 34 9 18 9	13.3	PIK3C2A, VEGFA, BMP6, SCARB1, CHKA, CETP
35	troglitazone32 42 9 9	12.1	SERPINE1, BMP6, BIRC5, BCL2, LEP, UCP2
36	il 1032	8.8	BMP6, LIF, IL10, IL15, IL1A, IL1B
37	pdtc32	8.8	BIRC5, BCL2, XDH, IL1A, IL1B, IL4
38	15-deoxy-delta-12,14-prostaglandin j232	INF	SERPINE1, VEGFA, BMP6, BIRC5, IL10, IL1B
39	arginine32	INF	PIK3C2A, NCOA2, SGK1, SERPINA6, LIF, BLVRB
40	cyclosporin a32 42	INF	PIK3C2A, KITLG, VDAC1, LIF, LEP, MTHFR
41	carbohydrates32	INF	SERPINA6, SCARB1, UCP2, S100A6, CFI, CETP
42	glutamine32	INF	NCOA2, KIT, BRCA1, BRCA2, VDAC1, BMP6
43	resveratrol32 9 18 9	INF	BRCA1, BRCA2, VEGFA, BIRC5, BCL2, BAX
44	glutamate32	INF	SGK1, GC, VDAC1, BMP6, BLVRB, CLU
45	alpha tocopherol32	INF	LIF, SCARB1, CKM, LEP, CHKA, MTHFR
46	gnrh32	INF	KITLG, SERPINE1, BLVRB, LHB, LHCGR, LEP
47	dexamethasone32 42 34 9 9	INF	NCOA2, SGK1, KITLG, SERPINA6, SERPINE1, VEGFA
48	lysine32	INF	NCOA2, SERPINA1, BRCA1, VDAC1, , PAPPA
49	doxorubicin32 34 9 9	INF	PIK3C2A, KIT, KITLG, BRCA1, VEGFA, BMP6
50	ascorbic acid32 18	INF	LIF, BDNF, CHKA, XRCC1, CGA, CGB5

Cellular components related to infertility according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	, TUBGCP3, CYCS, CYP19A1, ODF2, OAZ3
2	cytoplasm	GO:005737	INF	CTH, SPANXC, SPA17, SPANXE, SPAG6, SPAG1
3	perinuclear region of cytoplasm	GO:048471	11.8	NOS1, PLCZ1, CTLA4, SPP1, SPAG9, NOS2
4	extracellular space	GO:005615	11.1	IL8, MICA, ASIP, FN1, KAL1, CETP
5	integral to plasma membrane	GO:005887	10.8	ABCC1, ZYX, CTLA4, TNFSF11, TNF, TPO
6	secretory granule	GO:030141	10.3	SPACA3, PLAT, ELANE, TF, OXT, POMC
7	external side of plasma membrane	GO:009897	10.0	CCR5, IFNG, CALR, HLA-DRB1, TNF, DLK1
8	cell surface	GO:009986	10.0	PLAT, TNF, TPO, GHSR, CALR, HSPD1
9	platelet alpha granule lumen	GO:031093	9.8	F5, ALB, F13A1, TIMP1, TGFB1, TGFB2
10	extracellular region	GO:005576	INF	EPPIN, EPHA3, ADM, C3, C5, EFNA1

Biological processes related to infertility according to GeneDecks:

(show top 50)    (show all 55)

id	Name	GO ID	Score	Top Affiliating Genes
1	spermatogenesis	GO:007283	17.1	REC8, KIT, SERPINA5, BRCA2, BPY2C, BOLL
2	multicellular organismal development	GO:007275	15.4	BOLL, LIF, PAEP, LEFTY2, LEPR, MORC1
3	male gonad development	GO:008584	12.5	KLHL10, KIT, KITLG, BCL2, LHB, LHCGR
4	spermatid development	GO:007286	12.4	KLHL10, REC8, KIT, PACRG, YBX2, HSPA2
5	sperm motility	GO:030317	12.0	APOB, CATSPER2, CATSPER1, AKAP4, TNP1, TNP2
6	glutathione metabolic process	GO:006749	11.7	GSR, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5
7	positive regulation of cell proliferation	GO:008284	11.5	KIT, VEGFA, LIF, LIFR, BIRC5, LEP
8	female gamete generation	GO:007292	11.5	BMP15, MSH4, FSHB, FSHR, DMC1, SPO11
9	female pregnancy	GO:007565	11.4	GC, LIPE, PAPPA, BCL2, LEP, FSHB
10	response to estradiol stimulus	GO:032355	11.2	GC, SERPINA1, BRCA2, INSR, IL1B, ANXA1
11	positive regulation of MAPK cascade	GO:043410	11.2	KIT, LIF, LEP, CDH2, ITGB1, AR
12	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	11.1	KIT, LIF, LEP, FGFR3, IL15, IL23A
13	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.8	KITLG, VEGFA, LIF, CD44, ITGB1, ITGB3
14	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.7	CLU, AR, INS, IL1B, IL6, IL6R
15	response to progesterone stimulus	GO:032570	10.7	CCL2, ERBB4, TLR4, TGFB1, TGFB2, TGFB3
16	response to cytokine stimulus	GO:034097	10.6	SERPINA1, SERPINE1, LIFR, BCL2, IL4, IL6R
17	lipid metabolic process	GO:006629	10.5	LIPE, CLU, SCARB1, CHKA, CETP, APOA1
18	positive regulation of cell migration	GO:030335	10.5	VEGFA, LAMB1, CGA, FSHB, ITGAV, ITGB1
19	negative regulation of apoptotic process	GO:043066	10.5	SERPINE1, VEGFA, CLU, BCL2, BCL2L2, LEP
20	positive regulation of angiogenesis	GO:045766	10.5	SERPINE1, VEGFA, IL1A, IL1B, ANXA3, CCL5
21	negative regulation of cell proliferation	GO:008285	10.5	LIF, CD9, ITGB1, FOXP3, INHBA, IL1A
22	blood vessel remodeling	GO:001974	10.5	SEMA3C, LIF, BAX, IGF1, CBS, NOS3
23	response to activity	GO:014823	10.4	ITGB1, INSR, IL10, MAS1, CCL2, CCL5
24	platelet activation	GO:030168	10.4	SERPINA1, SERPINE1, SERPING1, VEGFA, CLU, LEFTY2
25	regulation of blood pressure	GO:008217	10.4	SGK1, LEP, P2RX1, HMOX1, PPARG, NOS3
26	platelet degranulation	GO:002576	10.4	SERPINA1, SERPINE1, SERPING1, VEGFA, CLU, LEFTY2
27	cellular response to lipopolysaccharide	GO:071222	10.3	SERPINE1, GSTP1, IL10, IL8, CCL2, CCR5
28	acute-phase response	GO:006953	10.3	SERPINA1, FN1, INS, IL6, IL6R, MBL2
29	positive regulation of nitric oxide biosynthetic process	GO:045429	10.3	INS, INSR, IL1B, IFNG, HSP90AA1, ESR1
30	response to estrogen stimulus	GO:043627	10.2	SERPINE1, BRCA1, BCL2, FAS, CCL5, ESR1
31	cytokine-mediated signaling pathway	GO:019221	10.2	KIT, LIFR, CD44, IL1A, IL1B, IL5
32	positive regulation of osteoclast differentiation	GO:045672	10.2	IL17A, IL23A, CCL5, IFNG, TNF, TNFSF11
33	positive regulation of mitosis	GO:045840	10.1	INS, INSR, IL1A, IL1B, IGF2, IGF1
34	anti-apoptosis	GO:006916	10.0	BIRC5, BDNF, BCL2, BCL2L2, MUC1, GSTP1
35	immune response	GO:006955	10.0	KIR2DL1, KIR2DL3, SEMA3C, BMP6, LIF, CHST4
36	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.9	ZNF148, NCOA2, SERPINE1, BRCA1, VEGFA, BMP6
37	blood coagulation	GO:007596	9.9	SERPINA1, SERPINE1, SERPING1, VEGFA, CLU, LEFTY2
38	lipopolysaccharide-mediated signaling pathway	GO:031663	9.9	SCARB1, IL1B, CCL2, CCL5, TNF, NOS3
39	response to hypoxia	GO:001666	9.8	SERPINA1, VEGFA, BCL2, LEP, UBE2B, XRCC1
40	response to glucocorticoid stimulus	GO:051384	9.8	SERPINE1, INSR, IL10, IL1B, IL6, FAS
41	positive regulation of apoptotic process	GO:043065	INF	CLU, BAX, ITGB1, , IL1B, FAS
42	response to drug	GO:042493	INF	SEMA3C, LIPE, , BDNF, BCL2, LHCGR
43	ovarian follicle development	GO:001541	INF	KIT, KITLG, BMP15, BCL2, LHCGR, BAX
44	inflammatory response	GO:006954	INF	KIT, BMP6, , CHST4, MIF, IL10
45	single fertilization	GO:007338	INF	BPY2C, CLGN, , XKRY, CD46, AKAP4
46	cell differentiation	GO:030154	INF	BOLL, PAPPA, MORC1, , ARNT, INHA
47	cell-cell signaling	GO:007267	INF	PCSK5, LHB, CHST4, CGA, CGB, ASIP
48	small molecule metabolic process	GO:044281	INF	PIK3C2A, NCOA2, GC, LIPE, BLVRB, LHB
49	positive regulation of transcription, DNA-dependent	GO:045893	INF	BRCA1, BRCA2, PAX8, CDH1, , FOXP3
50	signal transduction	GO:007165	INF	KIT, KITLG, LHB, CHKA, S100A6, P2RX1

Molecular functions related to infertility according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor binding	GO:005102	11.5	NOS2, CRH, TNFSF13B, GJA1, GLA, CAT
2	hormone activity	GO:005179	11.2	GNRH1, GNRH2, GH1, SST, CRH, TG
3	glutathione transferase activity	GO:004364	11.1	HPGDS, GSTT1, GSTP1, GSTM1, GSTK1, GSTA5
4	cytokine activity	GO:005125	10.8	GDF9, IL15, IL11, IL10, INHBA, INHA
5	NADP binding	GO:050661	10.8	GAPDH, NOS3, NOS2, NOS1, TXNRD2, CAT
6	growth factor activity	GO:008083	10.5	IL5, IL6, IGF2, IGF1, AMH, F2
7	protease binding	GO:002020	10.3	INSL3, HSPA1B, TNF, ELANE, POLG, INS
8	protein homodimerization activity	GO:042803	INF	HMOX1, HPGDS, GLA, CAT, HSP90AA1, CBS
9	protein binding	GO:005515	INF	TGFB2, ELANE, ACR, ACE, EIF5A2, ABCC2