Aliases & Classifications for Infertility

MalaCards integrated aliases for Infertility:

Name: Infertility 12 29 52 41 3 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5223
MeSH 42 D007246
NCIt 47 C3836
UMLS 69 C0021359

Summaries for Infertility

MedlinePlus : 41 infertility means not being able to become pregnant after a year of trying. if a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. infertility is fairly common. after one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. about a third of the time, infertility can be traced to the woman. in another third of cases, it is because of the man. the rest of the time, it is because of both partners or no cause can be found. there are treatments that are specifically for men or for women. some involve both partners. drugs, assisted reproductive technology, and surgery are common treatments. happily, many couples treated for infertility go on to have babies. nih: national institute of child health and human development

MalaCards based summary : Infertility is related to hypogonadism and spermatogenic failure, y-linked, 1, and has symptoms including pelvic pain An important gene associated with Infertility is DAZL (Deleted In Azoospermia Like), and among its related pathways/superpathways are DAG and IP3 signaling and G alpha (s) signalling events. The drugs Metformin and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and skin, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 72 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

Related Diseases for Infertility

Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
id Related Disease Score Top Affiliating Genes
1 hypogonadism 32.5 CYP19A1 INHA NR5A1
2 spermatogenic failure, y-linked, 1 31.5 FSHR NR5A1
3 ovarian hyperstimulation syndrome 30.4 CYP19A1 FSHR LHCGR
4 male infertility 12.4
5 deafness-infertility syndrome 12.3
6 y chromosome infertility 12.2
7 catsper1-related nonsyndromic male infertility 12.0
8 catsper-related male infertility 11.9
9 female infertility of uterine origin 11.9
10 non-syndromic male infertility due to sperm motility disorder 11.9
11 rare idiopathic male infertility 11.8
12 spermatogenic failure 6 11.8
13 infertility due to extratesticular cause 11.7
14 spermatogenic failure 5 11.7
15 male infertility with spermatogenesis disorder 11.7
16 male infertility with spermatogenesis disorder due to single gene mutation 11.7
17 male infertility with teratozoospermia due to single gene mutation 11.7
18 female infertility due to oocyte meiotic arrest 11.7
19 macrozoospermia 11.7
20 oocyte maturation defect 1 11.5
21 young syndrome 11.4
22 spermatogenic failure 7 11.3
23 spermatogenic failure, y-linked, 2 11.3
24 endometriosis 11.3
25 spermatogenic failure 17 11.2
26 spermatogenic failure, x-linked, 2 11.2
27 azoospermia 11.2
28 pelvic inflammatory disease 11.2
29 polycystic ovary syndrome 11.2
30 cystic fibrosis 11.1
31 turner syndrome 11.1
32 cryptorchidism 11.1
33 hyperprolactinemia 11.1
34 hypogonadotropic hypogonadism 11.0
35 primary ciliary dyskinesia 11.0
36 mumps 11.0
37 congenital bilateral absence of vas deferens 11.0
38 sertoli cell-only syndrome 11.0
39 uterine fibroid 11.0
40 oligospermia 11.0
41 anovulation 10.9
42 testicular cancer 10.9
43 testicular germ cell tumor 10.9
44 schistosomiasis 10.9
45 gonadal dysgenesis 10.9
46 47,xyy syndrome 10.9
47 ovarian response to fsh stimulation 10.8 FSHR INHA
48 retinitis pigmentosa, y-linked 10.8 DAZ1 DAZ4 USP9Y
49 nephronophthisis-like nephropathy 1 10.7 DAZ1 DAZL USP9Y
50 precocious puberty, male 10.7 CYP19A1 FSHR LHCGR

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility

Symptoms & Phenotypes for Infertility

UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 CATSPER2 CYP19A1 DPY19L2 FSHB FSHR INSL3
2 endocrine/exocrine gland MP:0005379 9.7 CYP19A1 DPY19L2 FSHB FSHR INHA INSL3
3 reproductive system MP:0005389 9.4 INSL3 LHB LHCGR NR5A1 ZP1 ZP3

Drugs & Therapeutics for Infertility

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1177)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
2
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
3
Ganirelix Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 123246-29-7, 124904-93-4 25081094
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
6
Diazepam Approved, Illicit, Vet_approved Phase 4 439-14-5 3016
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
8
Meperidine Approved Phase 4,Phase 2,Phase 3 57-42-1 4058
9
Midazolam Approved, Illicit Phase 4,Phase 1,Phase 2 59467-70-8 4192
10
Cetrorelix Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 120287-85-6 16129715 25074887
11
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757
12
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 50-02-2 5743
14
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 3911 657181
15
Dimenhydrinate Approved Phase 4 523-87-5 441281
16
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 9004-61-9 53477741 24759
17
Selenium Approved, Vet_approved Phase 4,Phase 3,Phase 2 7782-49-2
18
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
19
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
20
Levobupivacaine Approved Phase 4 27262-47-1 92253
21
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 57-27-2 5288826
22 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
24
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
25
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
26
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
27
Thrombin Approved Phase 4,Phase 3,Phase 2,Early Phase 1
28
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
29
Aluminum hydroxide Approved Phase 4,Phase 2,Phase 3,Phase 1 21645-51-2
30
Neomycin Approved, Vet_approved Phase 4,Phase 3,Phase 1 1404-04-2 8378
31
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 84057-95-4 71273 175805
32
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
33 Povidone-iodine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 25655-41-8
34
Succinylcholine Approved Phase 4 306-40-1 5314
35
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
36
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
37
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
38
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
39
Menotropins Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 61489-71-2, 9002-68-0 5360545
40
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 772 46507594
41
Liraglutide Approved Phase 4 204656-20-2 44147092
42
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-56-1 9552079 2713
43
Buserelin Approved Phase 4,Phase 3,Phase 1,Phase 2 57982-77-1
44
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 2216-51-5 16666
45
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
46
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
47
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
48
Povidone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 9003-39-8
49
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 299-42-3 9294
50
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 56-81-5 753

Interventional clinical trials:

(show top 50) (show all 3805)

id Name Status NCT ID Phase Drugs
1 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
2 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
3 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
4 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
5 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
6 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
7 Biosimilar Versus Urinary Gonadotropins Unknown status NCT02503605 Phase 4 Biosimilar recombinant FSH;Urinary FSH
8 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
9 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
10 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
11 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4 Human Chorionic Gonadotropin (HCG)
12 Methylprednisolone Addition in IVF Treatment of Infertile Couples Unknown status NCT01220791 Phase 4
13 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
14 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
15 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Unknown status NCT02494180 Phase 4 fentanyl;pethidine;Diazepam;Midazolam
16 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4 Elonva;Puregon
17 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4 Corifollitropin alfa
18 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
19 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
20 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
21 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4 crinone (progesterone 8%, vaginal application)
22 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4 HCG;Lupron Trigger;Dual Trigger
23 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
24 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
25 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
26 Use of Corifolitropin Alfa in Oocyte Donors Unknown status NCT02213627 Phase 4 Corifollitropin alfa;Recombinant FSH;HP-hMG
27 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
28 Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF Unknown status NCT02070198 Phase 4 Long acting FSH and GnRH antagonist;Daily FSH and GnRH antagonist;Triptorelin and recombinant FSH
29 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
30 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
31 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
32 The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement Unknown status NCT01312415 Phase 4 Levobupivacaine;Intrathecal morphine
33 The Effect of Intramuscular Dexmedetomidine on Emergence Agitation in Children Undergoing With or Without Tube Insertion Under General Anesthesia Unknown status NCT01535287 Phase 4 Dexmedetomidine
34 Negative Pressure Wound Therapy After Cesarean Delivery Unknown status NCT01637870 Phase 4
35 Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate Unknown status NCT00480376 Phase 4 ofloxacin;gentamicin
36 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Unknown status NCT02097017 Phase 4 Lidocaine
37 Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults Unknown status NCT01967368 Phase 4 Intanza;Vaxigrip
38 Arterial Catheter to Monitor Glycemia Unknown status NCT01176279 Phase 4
39 Spinal Cord Stimulation (SCS) in Refractory Angina Unknown status NCT00121654 Phase 4
40 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4 Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
41 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
42 The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound Unknown status NCT00813631 Phase 4
43 Cellular Immunity in Adult Hepatitis B-vaccinated Serologic Non-responders Unknown status NCT01451801 Phase 4
44 Corticosteroid Therapy for Severe Community-Acquired Pneumonia Unknown status NCT02552342 Phase 4 methylprednisolone;Normal saline
45 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
46 The Regain of Gastrointestinal Motility After General Anaesthesia Versus Spinal Anaesthesia in Caesarean Section Unknown status NCT02504749 Phase 4
47 A Trial Comparing Adductor Canal Catheter and Intraarticular Catheter Following Primary Total Knee Arthroplasty Unknown status NCT02497911 Phase 4 Ropivicaine;Bupivicaine
48 The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement Unknown status NCT01312077 Phase 4 Levobupivacaine;Intrathecal morphine
49 Serratus Anterior Plane Block Versus Paravertebral Block for Postmastectomy Analgesia Unknown status NCT02103946 Phase 4
50 Home Usage of Conception Kit Instructions Unknown status NCT00326651 Phase 4

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: infertility

Genetic Tests for Infertility

Genetic tests related to Infertility:

id Genetic test Affiliating Genes
1 Infertility 29

Anatomical Context for Infertility

MalaCards organs/tissues related to Infertility:

39
Ovary, Testes, Skin, Bone, Prostate, Eye, Lung

Publications for Infertility

Articles related to Infertility:

(show top 50) (show all 2669)
id Title Authors Year
1
Linking stress and infertility: a novel role for ghrelin. ( 28938425 )
2017
2
Assessing factors associated with infertility using a couple-based approach. ( 28084027 )
2017
3
Mutation in TDRD9 causes non-obstructive azoospermia in infertile men. ( 28536242 )
2017
4
TTY2 genes deletions as genetic risk factor of male infertility. ( 28364784 )
2017
5
The effects of tomato juice on male infertility. ( 28049263 )
2017
6
Low fertility awareness in U.S. reproductive-aged women and medical trainees: creation and validation of the Fertility & Infertility Treatment Knowledge Score (FIT-KS). ( 28911930 )
2017
7
Male infertility - The other side of the equation. ( 28892594 )
2017
8
The Gulf oil spill, miscarriage, and infertility: the GROWH study. ( 28918439 )
2017
9
Prevalence and management of incidental small testicular masses discovered on ultrasonographic evaluation of male infertility. ( 28789946 )
2017
10
Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella. ( 28552195 )
2017
11
Varicocele and male infertility. ( 28675168 )
2017
12
Role of Glutathione-S-Transferase Family Genes in Male Infertility. ( 28944422 )
2017
13
Aryl hydrocarbon receptor (AhR) rs2066853 gene polymorphism association with infertile oligoasthenoteratozoospermic men and seminal oxidative stress. ( 28161861 )
2017
14
The susceptibility of FSHB -211GA >A T and FSHR G-29A, 919AA >A G, 2039AA >A G polymorphisms to men infertility: an association study and meta-analysis. ( 28764642 )
2017
15
Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCIP. ( 28270562 )
2017
16
Mild androgen insensitivity syndrome (MAIS): the identification of c.1783C>T mutation in two unrelated infertile men. ( 28659371 )
2017
17
Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility. ( 28797078 )
2017
18
ABO blood group incompatibility and infertility: still an open debate. ( 28104243 )
2017
19
Fluorescence in situ hybridisation sperm examination is significantly impaired in all categories of male infertility. ( 28762516 )
2017
20
Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility. ( 28646452 )
2017
21
In vitro progesterone production by luteinized human mural granulosa cells is modulated by activation of AMPK and cause of infertility. ( 28938894 )
2017
22
DNAH1 gene mutations and their potential association with dysplasia of the sperm fibrous sheath and infertility in the Han Chinese population. ( 28577616 )
2017
23
Idiopathic male infertility related to periodontal and caries status. ( 28746727 )
2017
24
Delayed treatment of undescended testes may promote hypogonadism and infertility. ( 28070708 )
2017
25
Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease. ( 27898568 )
2017
26
Male factor infertility: Declining sperm counts - the never-ending story. ( 28949326 )
2017
27
Maternal uniparental disomy of chromosome 15 and concomitant STRC and CATSPER2 deletion-mediated deafness-infertility syndrome. ( 28317263 )
2017
28
Comparative analysis of testis transcriptomes associated with male infertility in cattleyak. ( 27865410 )
2017
29
Intrafollicular soluble RAGE benefits embryo development and predicts clinical pregnancy in infertile patients of advanced maternal age undergoing in vitro fertilization. ( 28397051 )
2017
30
Chronic Pelvic Pain and Infertility Resulting from Unrecognized Retained Laminaria. ( 28932611 )
2017
31
Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure. ( 28608596 )
2017
32
Pregnancy, Hormonal Treatments for Infertility, Contraception, and Menopause in Women After Ischemic Stroke: A Consensus Document. ( 28070003 )
2017
33
Resolution of infertility and number of children: 1386 couples followed for a median of 13 years. ( 28938738 )
2017
34
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China: A STROBE-compliant article. ( 28796064 )
2017
35
Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men. ( 28934280 )
2017
36
Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis. ( 28552346 )
2017
37
Infertility: A primer for primary care providers. ( 28953057 )
2017
38
Office-based andrology and male infertility procedures-a cost-effective alternative. ( 28904909 )
2017
39
Projecting the potential impact of the Cap-Scorea8c on clinical pregnancy, live births, and medical costs in couples with unexplained infertility. ( 28942518 )
2017
40
Activity of LPO Processes in Women with Polycystic Ovarian Syndrome and Infertility. ( 28091905 )
2017
41
Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility. ( 28089575 )
2017
42
Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation. ( 28476888 )
2017
43
Screening of Two Neighboring CFTR Mutations in Iranian Infertile Men with Non-Obstructive Azoospermia. ( 28042420 )
2017
44
Re: Causes of Male Infertility: A 9-Year Prospective Monocentre Study on 1737 Patients with Reduced Total Sperm Counts. ( 28817890 )
2017
45
Implantation Failure Is Associated With Increased I+-Inhibin and I^-Glycan Gene Expression in Secretory Phase Endometrium: Nested Case-Control Study of Infertile Women Undergoing IVF/Fresh Embryo Transfer. ( 27628954 )
2017
46
Associations between male infertility and ancestry in South Americans: a case control study. ( 28747152 )
2017
47
Erratum: Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]. ( 28496306 )
2017
48
The role of microsurgical varicocelectomy in treating male infertility. ( 28904905 )
2017
49
Genetics of mitochondrial dysfunction and infertility. ( 27748512 )
2017
50
Male Infertility Associated with a Supernumerary Marker Chromosome. ( 28879694 )
2017

Variations for Infertility

ClinVar genetic disease variations for Infertility:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NPHP4 NM_015102.4(NPHP4): c.2044C> T (p.Arg682Ter) single nucleotide variant Pathogenic/Likely pathogenic rs137852920 GRCh37 Chromosome 1, 5964776: 5964776

Copy number variations for Infertility from CNVD:

7 (show all 50)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion AZFb infertility
13 266750 Y 1 57772954 Microdeletion AZFc infertility
14 266796 Y 11300000 27200000 Deletion AZF infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZFa infertility
17 266827 Y 11300000 27200000 Microdeletion AZFb infertility
18 266828 Y 11300000 27200000 Microdeletion AZFc infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4LY infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion GOLGAZLY infertility
27 266840 Y 11300000 27200000 Microdeletion NAHR infertility
28 266841 Y 11300000 27200000 Microdeletion NOA infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF infertility
32 266975 Y 174481503 174538309 Microdeletions AZF infertility
33 266976 Y 174481503 174538309 Microdeletions AZFA infertility
34 267088 Y 23407118 25740308 Copy number TTTY17 Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4LY Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation ATPase6 Infertility
49 267527 mtDNA 1 16569 Mutation CYTB Infertility
50 267528 1 183532144 183553084 Mutation ND1 Infertility

Expression for Infertility

Search GEO for disease gene expression data for Infertility.

Pathways for Infertility

GO Terms for Infertility

Biological processes related to Infertility according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.85 FSHB INHA INSL3 LHB NR5A1
2 transforming growth factor beta receptor signaling pathway GO:0007179 9.74 FSHB LEFTY2 USP9Y
3 BMP signaling pathway GO:0030509 9.73 INHA LEFTY2 USP9Y
4 single fertilization GO:0007338 9.71 SPAG1 ZP1 ZP3
5 regulation of MAPK cascade GO:0043408 9.7 FSHR INHA LEFTY2
6 male gonad development GO:0008584 9.65 FSHR INHA LHB LHCGR NR5A1
7 peptide hormone processing GO:0016486 9.59 FSHB LHB
8 female gamete generation GO:0007292 9.58 FSHB FSHR
9 uterus development GO:0060065 9.58 CYP19A1 FSHR
10 female gonad development GO:0008585 9.58 CYP19A1 FSHR NR5A1
11 spermatogenesis GO:0007283 9.56 CATSPER2 DAZ1 DAZ4 DAZL DPY19L2 FSHR
12 positive regulation of adenylate cyclase activity GO:0045762 9.55 FSHR LHCGR
13 Sertoli cell proliferation GO:0060011 9.51 FSHB FSHR
14 regulation of osteoclast differentiation GO:0045670 9.5 FSHB FSHR LHCGR
15 progesterone biosynthetic process GO:0006701 9.48 FSHB LHB
16 primary ovarian follicle growth GO:0001545 9.43 FSHR LHCGR
17 positive regulation of translational initiation GO:0045948 9.37 DAZ1 DAZL
18 follicle-stimulating hormone signaling pathway GO:0042699 9.33 FSHB FSHR LHCGR
19 hormone-mediated signaling pathway GO:0009755 9.02 FSHB FSHR LHB LHCGR NR5A1
20 cell differentiation GO:0030154 10.04 CATSPER2 DAZ1 DAZ4 DAZL DPY19L2 INHA

Molecular functions related to Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.46 FSHB INHA INSL3 LHB
2 G-protein coupled peptide receptor activity GO:0008528 9.37 FSHR LHCGR
3 protein-hormone receptor activity GO:0016500 9.26 FSHR LHCGR
4 mRNA 3-UTR binding GO:0003730 9.02 DAZL
5 follicle-stimulating hormone receptor activity GO:0004963 8.96 FSHR LHCGR
6 translation activator activity GO:0008494 8.62 DAZ1 DAZL

Sources for Infertility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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