MCID: INF037
MIFTS: 50

Inflammatory Bowel Disease malady

Summaries for Inflammatory Bowel Disease

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3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

MalaCards: Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to crohn's disease and ulcerative colitis. An important gene associated with Inflammatory Bowel Disease is NOD2 (nucleotide-binding oligomerization domain containing 2). The drugs cromolyn sodium and cromolyn have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and small intestine.

Wikipedia:63 In medicine, inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and... more...

Description from OMIM:46 612244, 612245, 613148, 611081, 266600 612261, 612567 more

Aliases & Classifications for Inflammatory Bowel Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM
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Aliases & Descriptions:

inflammatory bowel disease 8 10
inflammatory bowel diseases 44 60


External Ids:

Disease Ontology8 DOID:0050589

Related Diseases for Inflammatory Bowel Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 23
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 12 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 5 Inflammatory Bowel Disease 19
Inflammatory Bowel Disease 3 Inflammatory Bowel Disease 13
Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 16 Inflammatory Bowel Disease 15
Inflammatory Bowel Disease 20 Inflammatory Bowel Disease 2
Inflammatory Bowel Disease 26 Inflammatory Bowel Disease 27
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 8
Inflammatory Bowel Disease 1 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 24

Diseases related to Inflammatory Bowel Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease31.3NOD2, ATG16L1
2ulcerative colitis31.2NOD2, ATG16L1
3intestinal disease11.0
4colonic disease11.0
5cholangitis10.8
6sclerosing cholangitis10.8
7pyoderma10.7
8pyoderma gangrenosum10.7
9irritable bowel syndrome10.7
10chromosomal disease10.7
11colorectal cancer10.7
12hepatitis10.6
13vascular disease10.6
14leukocyte disease10.6
15deficiency anemia10.6
16iron deficiency anemia10.6
17liver disease10.6
18skin disease10.6
19colon cancer10.6
20pancreatitis10.5
21celiac disease10.5
22osteoporosis10.5
23collagen disease10.5
24rectal disease10.5
25tuberculosis10.5
26ankylosing spondylitis10.5
27hepatitis a10.5
28arthritis10.5
29spondylitis10.5
30spondyloarthropathy10.5
31proctitis10.4
32hepatitis b10.4
33multiple sclerosis10.4
34peroxisomal disease10.4
35psoriasis10.4
36fecal incontinence10.4
37hyperhomocysteinemia10.4
38arthropathy10.4
39gastritis10.4
40thrombophilia10.4
41vein disease10.4
42toxic megacolon10.3
43thrombocytosis10.3
44autoimmune hepatitis10.3
45amyloidosis10.3
46glycogen storage disease10.3
47interstitial nephritis10.3
48megacolon10.3
49uveitis10.3
50inflammatory bowel disease 25, autosomal recessive10.3

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease:



Diseases related to inflammatory bowel disease

Clinical Features for Inflammatory Bowel Disease

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46OMIM
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Clinical features from OMIM:

612244,612245,613148,611081,266600,612261,612567

Drugs & Therapeutics for Inflammatory Bowel Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Inflammatory Bowel Disease

Drug clinical trials:

Search ClinicalTrials for Inflammatory Bowel Disease

Search NIH Clinical Center for Inflammatory Bowel Disease

Search CenterWatch for Inflammatory Bowel Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Inflammatory Bowel Disease

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Anatomical Context for Inflammatory Bowel Disease

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32MalaCards
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MalaCards organs/tissues related to Inflammatory Bowel Disease:

32
Colon, T cells, Small intestine, Bone, Endothelial, Testes, Liver, Skin, Monocytes, B cells, Myeloid, Kidney, Smooth muscle, Heart, Pituitary, Thyroid, Whole blood, Breast, Nk cells, Appendix, Pons

Animal Models for Inflammatory Bowel Disease or affiliated genes

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Publications for Inflammatory Bowel Disease

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Sources:
50PubMed
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Articles related to Inflammatory Bowel Disease:

(show top 50)    (show all 2300)
idTitleAuthorsYear
1
Fecal hemoglobin and calprotectin are equally effective in identifying patients with inflammatory bowel disease with active endoscopic inflammation. (24374878)
2014
2
Current issues in pediatric inflammatory bowel disease-associated arthropathies. (24415857)
2014
3
Inflammatory bowel disease and novel endoscopic technologies. (24033394)
2014
4
Outcomes of rescue therapy in acute severe ulcerative colitis: data from the United Kingdom inflammatory bowel disease audit. (24004000)
2013
5
Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. (23874435)
2013
6
Biological therapy for dermatological manifestations of inflammatory bowel disease. (24303470)
2013
7
The value of focally enhanced gastritis in the diagnosis of pediatric inflammatory bowel diseases. (23207168)
2013
8
Meta-analysis: the impact of disease activity at conception on disease activity during pregnancy in patients with inflammatory bowel disease. (23855477)
2013
9
Comparative study of candidate housekeeping genes for quantification of target gene messenger RNA expression by real-time PCR in patients with inflammatory bowel disease. (24141710)
2013
10
Risk factors for depression in the elderly inflammatory bowel disease population. (23932782)
2013
11
Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. (23126519)
2013
12
How to achieve deep remission in treatment of inflammatory bowel disease. (24187881)
2013
13
Compartmentalized expression of Th1 and Th17 cytokines in pediatric inflammatory bowel diseases. (21994045)
2012
14
Portal vein thrombosis in inflammatory bowel diseases: a single-center case series. (22405175)
2012
15
Diagnostic value of calprotectin in irritable bowel syndrome and in inflammatory bowel disease. (22788087)
2012
16
Recombinant human erythropoietin in patients with inflammatory bowel disease and refractory anemia: a 15-year single center experience. (22261528)
2012
17
Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: a systematic review and meta-analysis. (22405161)
2012
18
Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease. (19408338)
2009
19
The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease. (19220323)
2009
20
Joint involvement associated with inflammatory bowel disease. (19897967)
2009
21
Association between Mycobacterium avium subsp. paratuberculosis DNA in blood and cellular and humoral immune response in inflammatory bowel disease patients and controls. (18922720)
2009
22
Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease. (19149741)
2009
23
Oral challenge with a methionine load in patients with inflammatory bowel disease: a better test to identify hyperhomocysteinemia. (17924554)
2008
24
Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. (18040078)
2008
25
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease. (17589947)
2007
26
Resistin: another rising biomarker in inflammatory bowel disease? (17998823)
2007
27
Genes, diet and inflammatory bowel disease. (17628615)
2007
28
When can TNF-alpha inhibitors against inflammatory bowel disease be withdrawn?]. (17571118)
2007
29
Genetic advances in inflammatory bowel disease. (16901383)
2006
30
Colonic epithelial cell expression of ICAM-1 relates to loss of surface continuity: a comparative study of inflammatory bowel disease and colonic neoplasms. (16497620)
2006
31
Inflammatory bowel disease: a new combination therapy for pouchitis. (15976743)
2005
32
Course of disease, drug treatment and health-related quality of life in patients with inflammatory bowel disease 5 years after initial diagnosis. (16148548)
2005
33
Activation antigens on colonic T cells in inflammatory bowel disease: effects of IL-10. (15762887)
2005
34
Review article: joint involvement in inflammatory bowel disease. (15352892)
2004
35
Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease. (15380529)
2004
36
Immunohistochemical expression of cyclin D1, cyclin E, p21/waf1 and p27/kip1 in inflammatory bowel disease: correlation with other cell-cycle-related proteins (Rb, p53, ki-67 and PCNA) and clinicopathological features. (15060836)
2004
37
Serological differentiation of inflammatory bowel diseases. (11981336)
2002
38
Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity. (12425429)
2002
39
Post-genome challenges against inflammatory bowel diseases]. (11197852)
2001
40
IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease. (11051278)
2000
41
Is interleukin-6 important in inflammatory bowel disease? (11196713)
2000
42
Interleukin-4 inhibits the increased production of vascular endothelial growth factor by peripheral blood mononuclear cells in patients with inflammatory bowel disease. (11149012)
2000
43
Growth factors in inflammatory bowel disease. (10028449)
1999
44
Nutrition in inflammatory bowel disease. (10079904)
1998
45
Gastric dilatation-volvulus in the dog with histological evidence of preexisting inflammatory bowel disease: a retrospective study of 23 cases. (8784718)
1996
46
Interleukin 8: cells of origin in inflammatory bowel disease. (8566866)
1996
47
Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Disease and Collagenous Colitis: No Association with Lactoferrin, I^-Glucuronidase, Myeloperoxidase, or Proteinase 3. (23282562)
1996
48
Antibodies to human recombinant lipocortin-I in inflammatory bowel disease. (8097682)
1993
49
Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. (1612485)
1992
50
Chronic inflammatory bowel disease in glycogen storage disease type 1B. (1779622)
1991

Genetic Variations for Inflammatory Bowel Disease

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Expression for genes affiliated with Inflammatory Bowel Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inflammatory Bowel Disease

Search GEO for disease gene expression data for Inflammatory Bowel Disease.

Pathways for genes affiliated with Inflammatory Bowel Disease

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Compounds for genes affiliated with Inflammatory Bowel Disease

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GO Terms for genes affiliated with Inflammatory Bowel Disease

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16Gene Ontology
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Biological processes related to Inflammatory Bowel Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stress-activated MAPK cascadeGO:05140310.8NOD2, AGT

Products for genes affiliated with Inflammatory Bowel Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inflammatory Bowel Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet