MCID: INF037
MIFTS: 45

Inflammatory Bowel Disease malady

Gastrointestinal diseases category

Summaries for Inflammatory Bowel Disease

About this section
Sources:
4CDC, 66Wikipedia, 48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
CDC:4 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohnā€™s disease.

MalaCards: Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to crohn's disease and ulcerative colitis. An important gene associated with Inflammatory Bowel Disease is NOD2 (nucleotide-binding oligomerization domain containing 2). The drugs cromolyn sodium and cromolyn have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and small intestine.

Wikipedia:66 In medicine, inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and... more...

Description from OMIM:48 612567, 612261, 612245, 612244, 266600 613148, 611081 more

Aliases & Classifications for Inflammatory Bowel Disease

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 48OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

inflammatory bowel disease 9 11
inflammatory bowel diseases 46 63


External Ids:

Disease Ontology9 DOID:0050589

Related Diseases for Inflammatory Bowel Disease

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 23
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 12 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 5 Inflammatory Bowel Disease 19
Inflammatory Bowel Disease 3 Inflammatory Bowel Disease 13
Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 16 Inflammatory Bowel Disease 15
Inflammatory Bowel Disease 20 Inflammatory Bowel Disease 2
Inflammatory Bowel Disease 26 Inflammatory Bowel Disease 27
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 8
Inflammatory Bowel Disease 1 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 24

Diseases related to Inflammatory Bowel Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease31.4NOD2, ATG16L1
2ulcerative colitis31.3NOD2, ATG16L1
3cholangitis10.8
4primary sclerosing cholangitis10.8
5sclerosing cholangitis10.8
6pyoderma10.7
7pyoderma gangrenosum10.7
8irritable bowel syndrome10.7
9colorectal cancer10.7
10endotheliitis10.7
11hepatitis10.6
12thromboembolism10.6
13deficiency anemia10.5
14iron deficiency anemia10.5
15colon cancer10.5
16pancreatitis10.5
17celiac disease10.5
18venous thrombosis10.5
19pouchitis10.5
20osteoporosis10.5
21tuberculosis10.5
22ankylosing spondylitis10.4
23arthritis10.4
24spondylitis10.4
25spondyloarthropathy10.4
26nodular regenerative hyperplasia10.4
27inflammatory bowel disease 210.4
28proctitis10.4
29multiple sclerosis10.4
30psoriasis10.4
31venous thromboembolism10.4
32inflammatory bowel disease 110.4
33hepatosplenic t-cell lymphoma10.4
34hyperhomocysteinemia10.4
35hepatitis b10.4
36arthropathy10.4
37gastritis10.4
38thrombophilia10.4
39collagenous colitis10.4
40inflammatory bowel disease 410.4
41fecal incontinence10.3
42toxic megacolon10.3
43thrombocytosis10.3
44amyloidosis10.3
45glycogen storage disease10.3
46interstitial nephritis10.3
47megacolon10.3
48uveitis10.3
49spondylarthropathy10.3
50inflammatory bowel disease 25, autosomal recessive10.3

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease:



Diseases related to inflammatory bowel disease

Symptoms for Inflammatory Bowel Disease

About this section
Sources:
48OMIM
See all sources


Clinical features from OMIM:

612567,612261,612245,612244,266600,613148,611081

Drugs & Therapeutics for Inflammatory Bowel Disease

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Inflammatory Bowel Disease

Drug clinical trials:

Search ClinicalTrials for Inflammatory Bowel Disease

Search NIH Clinical Center for Inflammatory Bowel Disease

Search CenterWatch for Inflammatory Bowel Disease

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Inflammatory Bowel Disease

About this section

Anatomical Context for Inflammatory Bowel Disease

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Inflammatory Bowel Disease:

34
Colon, T cells, Small intestine, Bone, Endothelial, Testes, Liver, Skin, Monocytes, B cells, Myeloid, Kidney, Smooth muscle, Appendix, Pituitary, Nk cells, Breast, Thyroid, Heart, Whole blood, Pons

Animal Models for Inflammatory Bowel Disease or affiliated genes

About this section

Publications for Inflammatory Bowel Disease

About this section
Sources:
53PubMed
See all sources

Articles related to Inflammatory Bowel Disease:

(show top 50)    (show all 2268)
idTitleAuthorsYear
1
Management of psoriasis in patients treated with anti-TNF-I+ therapy for inflammatory bowel disease. (23972498)
2013
2
Factors associated with thiopurine non-adherence in patients with inflammatory bowel disease. (24099471)
2013
3
Acute segmentary ulcerative duodenitis induced by Streptococcus pyogenes mimicking inflammatory bowel disease. (23994254)
2013
4
Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry. (23745025)
2013
5
Exploring the role of the inflammatory bowel disease nurse specialist. (24037398)
2013
6
Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis. (21708824)
2012
7
Association between Cogan's syndrome and inflammatory bowel disease: a case series. (21272808)
2011
8
Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease. (22176654)
2011
9
Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. (19698701)
2010
10
Transcutaneous posterior tibial nerve stimulation for fecal incontinence in inflammatory bowel disease patients: a therapeutic option? (18972550)
2009
11
Interleukin-10 in inflammatory bowel disease. (19890110)
2009
12
Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study. (19309553)
2009
13
Bile synthesis in rat models of inflammatory bowel diseases. (17359490)
2007
14
Stimulating erythropoiesis in inflammatory bowel disease associated anemia. (17828809)
2007
15
Inflammatory bowel disease: clinical aspects and established and evolving therapies. (17499606)
2007
16
Phosphodiesterase 4 inhibitors and inflammatory bowel disease: emerging therapies in inflammatory bowel disease. (17714033)
2007
17
IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland. (17337463)
2007
18
5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease. (17889397)
2007
19
Genetic advances in inflammatory bowel disease. (16901383)
2006
20
Loss of fragile histidine triad protein expression in inflammatory bowel disease. (17143956)
2006
21
Role of the IBD5 susceptibility locus in the inflammatory bowel diseases. (16534425)
2006
22
Ubiquitin protein modification and signal transduction: implications for inflammatory bowel diseases. (16306773)
2005
23
Severe chronic active Epstein-Barr virus infection mimicking steroid-dependent inflammatory bowel disease. (15750464)
2005
24
Association of Fas-670 gene polymorphism with inflammatory bowel disease in Chinese patients. (15637757)
2005
25
The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease. (15842590)
2005
26
Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease. (15647604)
2005
27
Probiotic Lactobacillus-induced improvement in murine chronic inflammatory bowel disease is associated with the down-regulation of pro-inflammatory cytokines in lamina propria mononuclear cells. (15932502)
2005
28
Review article: bone disease in inflammatory bowel disease. (15352893)
2004
29
Key role of mast cells and their major secretory products in inflammatory bowel disease. (14760748)
2004
30
Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease. (15248378)
2004
31
Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. (14988837)
2004
32
Colonic expression of MUC2, MUC5AC, and TFF1 in inflammatory bowel disease in children. (15097436)
2004
33
Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms. (15223609)
2004
34
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. (14568967)
2003
35
Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. (12940924)
2003
36
Platelets and anticoagulant capacity in patients with inflammatory bowel disease. (12214155)
2002
37
Integrating anti-tumor necrosis factor therapy in inflammatory bowel disease: current and future perspectives. (11467623)
2001
38
Post-genome challenges against inflammatory bowel diseases]. (11197852)
2001
39
In vivo effects of recombinant human interleukin-10 on lymphocyte phenotypes and leukocyte activation markers in inflammatory bowel disease. (11094868)
2000
40
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. (10792371)
2000
41
Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease. (10749795)
2000
42
Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies. (10102970)
1999
43
Genetic analysis in Italian families with inflammatory bowel disease supports linkage to the IBD1 locus--a GISC study. (10439963)
1999
44
Growth factors in inflammatory bowel disease. (10028449)
1999
45
Current concept of the role of monocytes/macrophages in inflammatory bowel disease--balance of proinflammatory and immunosuppressive mediators. (9759608)
1998
46
Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease. (9609761)
1998
47
Visualising E-selectin in the detection and evaluation of inflammatory bowel disease. (9771404)
1998
48
Hemostatic abnormalities in inflammatory bowel disease. (9163067)
1996
49
Antibodies to intercellular adhesion molecule-1 ameliorate the inflammatory response in acetic acid-induced inflammatory bowel disease. (7616434)
1995
50
Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease. (8082495)
1994

Variations for Inflammatory Bowel Disease

About this section

Expression for genes affiliated with Inflammatory Bowel Disease

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Inflammatory Bowel Disease

Search GEO for disease gene expression data for Inflammatory Bowel Disease.

Pathways for genes affiliated with Inflammatory Bowel Disease

About this section

Compounds for genes affiliated with Inflammatory Bowel Disease

About this section

GO Terms for genes affiliated with Inflammatory Bowel Disease

About this section

Products for genes affiliated with Inflammatory Bowel Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inflammatory Bowel Disease

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet