MCID: INF037
MIFTS: 50

Inflammatory Bowel Disease malady

Summaries for Inflammatory Bowel Disease

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3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

MalaCards: Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to crohn's disease and ulcerative colitis. An important gene associated with Inflammatory Bowel Disease is NOD2 (nucleotide-binding oligomerization domain containing 2). The drugs cromolyn sodium and clidinium have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and small intestine.

Wikipedia:63 In medicine, inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and... more...

Description from OMIM:46 612244, 612245, 613148, 611081, 266600 612261, 612567 more

Aliases & Classifications for Inflammatory Bowel Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM
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Aliases & Descriptions:

inflammatory bowel disease 8 10
inflammatory bowel diseases 44 60


External Ids:

Disease Ontology8 DOID:0050589

Related Diseases for Inflammatory Bowel Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 23
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 12 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 5 Inflammatory Bowel Disease 19
Inflammatory Bowel Disease 3 Inflammatory Bowel Disease 13
Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 16 Inflammatory Bowel Disease 15
Inflammatory Bowel Disease 20 Inflammatory Bowel Disease 2
Inflammatory Bowel Disease 26 Inflammatory Bowel Disease 27
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 8
Inflammatory Bowel Disease 1 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 24

Diseases related to Inflammatory Bowel Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease31.3NOD2, ATG16L1
2ulcerative colitis31.2NOD2, ATG16L1
3intestinal disease11.0
4colonic disease11.0
5cholangitis10.8
6sclerosing cholangitis10.8
7pyoderma10.7
8pyoderma gangrenosum10.7
9irritable bowel syndrome10.7
10chromosomal disease10.7
11colorectal cancer10.7
12hepatitis10.6
13vascular disease10.6
14leukocyte disease10.6
15deficiency anemia10.6
16iron deficiency anemia10.6
17liver disease10.6
18skin disease10.6
19colon cancer10.6
20pancreatitis10.5
21celiac disease10.5
22osteoporosis10.5
23collagen disease10.5
24rectal disease10.5
25tuberculosis10.5
26ankylosing spondylitis10.5
27hepatitis a10.5
28arthritis10.5
29spondylitis10.5
30spondyloarthropathy10.5
31proctitis10.4
32hepatitis b10.4
33multiple sclerosis10.4
34peroxisomal disease10.4
35psoriasis10.4
36fecal incontinence10.4
37hyperhomocysteinemia10.4
38arthropathy10.4
39gastritis10.4
40thrombophilia10.4
41vein disease10.4
42toxic megacolon10.3
43thrombocytosis10.3
44autoimmune hepatitis10.3
45amyloidosis10.3
46glycogen storage disease10.3
47interstitial nephritis10.3
48megacolon10.3
49uveitis10.3
50inflammatory bowel disease 25, autosomal recessive10.3

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease:



Diseases related to inflammatory bowel disease

Clinical Features for Inflammatory Bowel Disease

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46OMIM
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Clinical features from OMIM:

612244,612245,613148,611081,266600,612261,612567

Drugs & Therapeutics for Inflammatory Bowel Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Inflammatory Bowel Disease

Drug clinical trials:

Search ClinicalTrials for Inflammatory Bowel Disease

Search NIH Clinical Center for Inflammatory Bowel Disease

Search CenterWatch for Inflammatory Bowel Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Inflammatory Bowel Disease

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Anatomical Context for Inflammatory Bowel Disease

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32MalaCards
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MalaCards organs/tissues related to Inflammatory Bowel Disease:

32
Colon, T cells, Small intestine, Bone, Endothelial, Testes, Liver, Skin, Monocytes, B cells, Myeloid, Kidney, Smooth muscle, Thyroid, Appendix, Pons, Whole blood, Heart, Nk cells, Breast, Pituitary

Animal Models for Inflammatory Bowel Disease or affiliated genes

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Publications for Inflammatory Bowel Disease

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Sources:
50PubMed
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Articles related to Inflammatory Bowel Disease:

(show top 50)    (show all 2300)
idTitleAuthorsYear
1
Cytokine ILa896 is required in Citrobacter rodentium infectiona89induced intestinal Th17 responses and promotes ILa8922 expression in inflammatory bowel disease. (24430732)
2014
2
Increased proportions of bifidobacterium and the lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease. (24226927)
2014
3
Endocrine therapy for growth retardation in paediatric inflammatory bowel disease. (24037779)
2014
4
Clostridium difficile infection in children with inflammatory Bowel Disease: Current Evidence. (24180405)
2013
5
Review article: dermatological complications of immunosuppressive and anti-TNF therapy in inflammatory bowel disease. (24099467)
2013
6
Interventions and targets aimed at improving quality in inflammatory bowel disease ambulatory care. (24151356)
2013
7
AVX-470: a novel oral anti-TNF antibody with therapeutic potential in inflammatory bowel disease. (23949620)
2013
8
Periodontitis and gingivitis in inflammatory bowel disease: a case-control study. (24216685)
2013
9
Adult-onset systemic Langerhans cell histiocytosis mimicking inflammatory bowel disease: the value of skin biopsy and review of cases of Langerhans cell histiocytosis with cutaneous involvement seen at the Mayo Clinic. (23621577)
2013
10
Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. (24183308)
2013
11
Education and imaging. Gastrointestinal: severe inflammatory bowel disease-associated pyoderma gangrenosum. (24147454)
2013
12
Balancing and communicating the risks and benefits of biologics in pediatric inflammatory bowel disease. (23867874)
2013
13
A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease. (24260458)
2013
14
Inflammatory bowel disease: An archetype disorder of outer environment sensor systems. (23919214)
2013
15
Help-seeking for fecal incontinence in people with inflammatory bowel disease. (24202227)
2013
16
PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis. (23224068)
2013
17
Transition of care in inflammatory bowel disease: mind the gap! Theory, practice and recommendations for an Australian context. (24237644)
2013
18
Intestinal and Peripheral Fibrinogen-Like Protein 2 Expression in Inflammatory Bowel Disease. (24287641)
2013
19
Management of cytomegalovirus infection in inflammatory bowel diseases. (22538204)
2012
20
Association between inflammatory bowel disease gene 5 (IBD5) and interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease. (22908971)
2012
21
The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer. (22741617)
2012
22
Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort. (22426692)
2012
23
Hepatosplenic T-cell lymphoma in inflammatory bowel disease: a possible thiopurine-induced chromosomal abnormality. (20927075)
2010
24
Detection of MEFV gene mutations in patients with inflammatory bowel disease. (19309279)
2009
25
IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. (17662091)
2008
26
Tumour necrosis factor alpha inhibitors: screening for tuberculosis infection in inflammatory bowel disease. (18241178)
2008
27
Comparison of a novel fecal marker--fecal tumor pyruvate kinase type M2 (M2-PK) with fecal calprotectin in patients with inflammatory bowel disease: a prospective study. (19097497)
2008
28
Effect of 5-aminosalicylates on renal function in patients with inflammatory bowel disease: 4-year follow-up study. (18928745)
2008
29
ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. (18047540)
2008
30
Correlation of the autophagosome gene ATG16L1 polymorphism and inflammatory bowel disease]. (18495612)
2008
31
Exclusive increase of CX3CR1+CD28-CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes. (17285595)
2007
32
Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha. (16195422)
2006
33
VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. (16293653)
2006
34
Association of Fas-670 gene polymorphism with inflammatory bowel disease in Chinese patients. (15637757)
2005
35
The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease. (15842590)
2005
36
Intestinal interleukin-13 in pediatric inflammatory bowel disease patients. (15472520)
2004
37
Optimizing anti-TNF treatment in inflammatory bowel disease. (15168370)
2004
38
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis). (12645796)
2003
39
Increased expression of interleukin 17 in inflammatory bowel disease. (12477762)
2003
40
Elevated serum PIIINP and laminin in inflammatory bowel disease indicate hepatobiliary and pancreatic dysfunction. (11995461)
2002
41
Germ therapy with IL-10 to treat inflammatory bowel diseases. (11074364)
2000
42
Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies. (11196710)
2000
43
Visualising E-selectin in the detection and evaluation of inflammatory bowel disease. (9771404)
1998
44
Cytokines in inflammatory bowel disease. (9523521)
1998
45
Myeloperoxidase concentrations in the stool as a new parameter of inflammatory bowel disease. (9658754)
1998
46
Polymorphism of the microsatellites and tumor necrosis factor genes in chronic inflammatory bowel diseases]. (9587492)
1997
47
Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa. (8691064)
1996
48
Pseudotumor cerebri associated with corticosteroid withdrawal in inflammatory bowel disease. (8129010)
1994
49
Activation of monocytes during inflammatory bowel disease. (1715713)
1991
50
Pneumatosis cystoides intestinalis mimicry of inflammatory bowel disease. (523894)
1979

Genetic Variations for Inflammatory Bowel Disease

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Expression for genes affiliated with Inflammatory Bowel Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inflammatory Bowel Disease

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Pathways for genes affiliated with Inflammatory Bowel Disease

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Compounds for genes affiliated with Inflammatory Bowel Disease

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GO Terms for genes affiliated with Inflammatory Bowel Disease

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16Gene Ontology
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Biological processes related to Inflammatory Bowel Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stress-activated MAPK cascadeGO:05140310.8NOD2, AGT

Products for genes affiliated with Inflammatory Bowel Disease

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Sources for Inflammatory Bowel Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet