Inflammatory Bowel Disease malady

CDC: Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.²

MalaCards: Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to carcinoma and pancreatitis. An important gene associated with Inflammatory Bowel Disease is ATG16L1 (autophagy related 16-like 1 (S. cerevisiae)), and among its related pathways are p53 Mediated Apoptosis and Chagas disease (American trypanosomiasis). The drugs cromolyn and clidinium bromide and the compounds sialic acid and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, smooth muscle and skeletal muscle, and related mouse phenotypes are liver/biliary system and mortality/aging.

Wikipedia: In medicine, inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and...⁴⁴ more...

Aliases & Descriptions:

inflammatory bowel disease 6 8 inflammatory bowel diseases 32 43

Disease types for inflammatory bowel disease family:

inflammatory bowel disease 12	inflammatory bowel disease 10
inflammatory bowel disease 14	inflammatory bowel disease 1
inflammatory bowel disease 21	inflammatory bowel disease 11
inflammatory bowel disease 15	inflammatory bowel disease 16
inflammatory bowel disease 18	inflammatory bowel disease 19
inflammatory bowel disease 2	inflammatory bowel disease 20
inflammatory bowel disease 22	inflammatory bowel disease 23
inflammatory bowel disease 24	inflammatory bowel disease 26
inflammatory bowel disease 27	inflammatory bowel disease 3
inflammatory bowel disease 4	inflammatory bowel disease 5
inflammatory bowel disease 6	inflammatory bowel disease 7
inflammatory bowel disease 8	inflammatory bowel disease 9
inflammatory bowel disease 13

Diseases related to inflammatory bowel disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 948)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	80.6	PIGR, RFC1, PDE4A, REG3A, REG4, RELA
2	pancreatitis	68.2	PDE4A, REG3A, REG4, RELA, RETN, WARS
3	ulcerative colitis	67.0	PDE4A, REG4, GCG, SELE, SELL, SELP
4	fibrosis	58.4	PDE4A, REG3A, RELA, RETN, RETNLB, KIT
5	lupus erythematosus	55.9	RETN, KIR2DL1, KIR2DL3, VWF, SFTPD, PCNA
6	psoriasis	55.7	RFC1, PDE4A, RETN, KIR2DL1, KIR2DL3, SFTPD
7	neuronitis	54.6	PDE4A, REG3A, RELA, RETN, WAS, KIT
8	cholesterol	54.1	RELA, RETN, VWF, SFTPD, GC, RBP4
9	colon cancer	54.0	RFC1, PDE4A, REEP6, REG4, RELA, RETN
10	crohn's disease	53.0	WAS, GCG, BPI, BMP7, BDKRB2, CHI3L1
11	peritonitis	50.7	REG4, RELA, KIT, KIR2DL1, KIR2DL3, VWF
12	hypoxia	49.9	PDE4A, RELA, RETNLB, WARS, KIT, VWF
13	diabetes mellitus	48.1	PDE4A, RETN, VWF, GCG, GC, RBP4
14	sepsis	46.9	PDE4A, RETN, SFTPD, RBP4, SELE, SELL
15	colon carcinoma	46.8	PIGR, RETNLB, KIT, SELE, SELL, SELP
16	systemic lupus erythematosus	46.7	VWF, RBP4, SELE, VIP, NAT2, VCAM1
17	celiac disease	46.3	SELE, SELL, VDR, MYO9B, ZMIZ1, BGLAP
18	anemia	46.2	RELA, KIT, VWF, PCNA, SELE, SELL
19	thrombosis	44.7	RFC1, RETN, VWF, PCNA, SELE, SELL
20	gonococcal synovitis	44.1	PIGR, PDE4A, REG3A, RELA, RETN, WARS
21	immunodeficiency	43.9	WAS, SELL, VIP, BPI, MYD88, BMP6
22	adenoma	43.2	PDE4A, REG3A, REG4, RETN, KIT, SFRP1
23	insulin resistance	42.3	RELA, RETN, RETNLB, VWF, GCG, RBP4
24	spondylitis	41.6	RELA, KIR2DL1, KIR2DL3, VWF, GC, SERPINA1
25	cholangitis	41.5	PCNA, BPI, CLDN1, SCT, MUC2, CEACAM3
26	sclerosing cholangitis	40.5	BPI, CLDN1, SCT, CEACAM3, ATG16L1, MPO
27	measles	40.1	RELA, SFTPD, RBP4, SELE, VCAM1, MYD88
28	leukemia	39.7	RFC1, PDE4A, RELA, RETN, KIT, KIR2DL1
29	osteoporosis	39.3	PDE4A, SFRP1, GCG, GC, RBP4, SELE
30	aortic aneurysm	38.7	RETN, VWF, SELE, SELL, SERPINC1, SERPINE1
31	eczema	38.7	WAS, SELE, VIP, CMA1, LGALS3, MPO
32	arthropathy	37.8	RETN, BPI, BMP6, BMP7, BGLAP, CIITA
33	twinning	37.5	RETN, VWF, GCG, RBP4, SERPINC1, SERPINE1
34	polyposis	37.3	REEP6, RELA, SFRP1, PCNA, SELE, SERPINE1
35	prostatitis	37.2	RFC1, PDE4A, REG4, RELA, RETN, KIT
36	irritable bowel syndrome	37.1	GCG, VIP, LEP, CHGA, LCT, S100A12
37	homocysteine	36.7	RFC1, RELA, RETN, VWF, PCNA, GCG
38	multiple sclerosis	36.5	ZMIZ1, UBD, MST1, CD24, CD14, CD6
39	tuberculosis	36.3	VDR, CD209, IL10, IL12B, IL1B, IL1RN
40	ankylosing spondylitis	36.1	SERPINA1, BGLAP, CD79A, CD40LG, MMP3, IL17A
41	connective tissue disease	36.0	VWF, SFTPD, SELE, SELL, VCAM1, BMP6
42	type 2 diabetes mellitus	35.9	RETN, VWF, GCG, GC, RBP4, SELE
43	venous thrombosis	35.8	VWF, SELP, SELPLG, SERPINC1, SERPINE1, MTHFR
44	rheumatoid arthritis	35.8	CIITA, MTHFR, CD40, MICB, MICA, MIF
45	common variable immunodeficiency	35.7	SELL, SERPINA1, BGLAP, LCK, XBP1, B2M
46	familial mediterranean fever	35.4	KIR2DL1, KIR2DL3, SELL, SELP, SERPINC1, SERPINE1
47	viral hepatitis	35.1	PCNA, SERPINC1, SERPINA1, SERPINA3, BGLAP, LEP
48	arthritis	35.0	SELL, SERPINA1, VIP, MMP3, IL17A, IL1A
49	cytomegalovirus infection	34.9	VWF, SELE, SELL, SELP, SERPINA1, VCAM1
50	thrombophilia	34.9	VWF, SELE, SELP, SERPINC1, SERPINE1, MTRR

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 clidinium, clidinium bromide, cromolyn, cromolyn sodium

MalaCards organs/tissues related to inflammatory bowel disease:

²²

MGI Mouse Phenotypes related to inflammatory bowel disease:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	INF	RETN, KIT, SERPINC1, VEGFA, LIF, CLN3
2	mortality/aging	MP:0010768	INF	RELA, RETNLB, VWF, SFRP1, SFTPD, GCG
3	homeostasis/metabolism phenotype	MP:0005376	INF	, REG3A, RELA, RETN, RETNLB, WAS
4	integument phenotype	MP:0010771	INF	RELA, KIT, SELP, , BRAF, BRCA1
5	limbs/digits/tail phenotype	MP:0005371	INF	RELA, KIT, SFRP1, BRCA1, VEGFA, VDR
6	cellular phenotype	MP:0005384	INF	RELA, WAS, KIT, VWF, PCNA, RBP4
7	embryogenesis phenotype	MP:0005380	INF	KIT, SFRP1, SERPINC1, SETD2, SERPINB5, NAT1
8	growth/size phenotype	MP:0005378	INF	RELA, KIT, SFRP1, SFTPD, GCG, SELE
9	reproductive system phenotype	MP:0005389	INF	, RBP4, VIP, NAT1, BRCA1, BRWD1
10	cardiovascular system phenotype	MP:0005385	INF	PDE4A, RELA, KIT, VWF, SFRP1, RBP4
11	muscle phenotype	MP:0005369	INF	RELA, KIT, RBP4, BRAF, BRCA1, VEGFA
12	craniofacial phenotype	MP:0005382	INF	KIT, NAGLU, ZMIZ1, ITGA4, , FLG
13	other phenotype	MP:0005395	11.2	LAMC2, JAK2, CDKN2A, CD40LG, ITGA6, ITGB3
14	pigmentation phenotype	MP:0001186	9.8	KIT, SERPINC1, NAGLU, BRAF, BRCA1, MYC
15	vision/eye phenotype	MP:0005391	INF	RELA, KIT, RBP4, SELE, SELP, SERPINC1
16	renal/urinary system phenotype	MP:0005367	INF	WAS, KIT, SELP, , NAGLU, BRAF
17	digestive/alimentary phenotype	MP:0005381	INF	, RETNLB, WAS, KIT, VWF, GCG
18	respiratory system phenotype	MP:0005388	INF	SFTPD, SELL, SELP, BRCA1, LIF, P2RY6
19	adipose tissue phenotype	MP:0005375	INF	RETN, SFRP1, SERPINE1, BRAF, BRCA1, MYC
20	normal phenotype	MP:0002873	INF	RELA, RBP4, SELE, VIL1, VIP, NAT1
21	behavior/neurological phenotype	MP:0005386	INF	KIT, SELE, SELP, VIP, VIPR1, NAGLU
22	tumorigenesis	MP:0002006	INF	WAS, KIT, SELL, SERPINE1, BRAF, BRCA1
23	no phenotypic analysis	MP:0003012	INF	SFRP1, PCNA, VEGFA, VCAM1, MYC, MYD88
24	endocrine/exocrine gland phenotype	MP:0005379	INF	WAS, SELL, VIPR1, BRCA1, BDKRB2, XDH
25	nervous system phenotype	MP:0003631	INF	PDE4A, RELA, KIT, VWF, SFRP1, SELP
26	hematopoietic system phenotype	MP:0005397	INF	, WAS, KIT, SFRP1, PCNA, BRAF
27	immune system phenotype	MP:0005387	INF	, PDE4A, RETNLB, WAS, KIT, VWF
28	skeleton phenotype	MP:0005390	INF	RELA, WAS, KIT, SFRP1, GC, NAGLU

Articles related to inflammatory bowel disease:

(show top 50)    (show all 1245)

id	Title	Authors	Year	Affiliating Genes
1	Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease . (21667320)	Wald F.A.... Salas P.J.	2011	MYH9
2	Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease. (20188614)	Yu W.... Koltun W.A.	2010	EDN1, NKX2-3
3	Practical guidelines for treating inflammatory bowel disease safely with anti-tumour necrosis factor therapy in Australia. (20446955)	Connell W.... Sparrow M.	2010	TNF
4	Mannose-binding lectin level and deficiency is not as sociated with inflammatory bowel diseases, disease phenotype, serology profile, and NOD2/CARD15 genotype in a large Hungarian cohort. (20079790)	Papp M.... Papp J.	2010	TLR4, MBL2, NOD2
5	Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers. (19274491)	Haas S.L.... BAPcker U.	2009	IL18
6	Nuclear pregnane X receptor single nucleotide polymor phism (-25385C/T) is not associated with inflammatory bowel disease in pediatri c patients. (19516190)	Lacher M.... Koletzko S.	2009	NR1I2
7	Review of fecal biomarkers in inflammatory bowel disease. (18543035)	Sutherland A.D.... Frizelle F.A.	2008	LTF
8	The role of genetics in inflammatory bowel disease. (18473763)	Henckaerts L.... Sans M.	2008	NOD1, NOD2, SLC22A4
9	Optimizing conventional therapy for inflammatory bowel disease. (19006615)	Schwartz M.... Cohen R.	2008	TPMT
10	Beyond TNF, Th1 and Th2 in inflammatory bowel disease. (18791115)	Shale M.... Ghosh S.	2008	TNF
11	Detailed assessment of NOD2/CARD15 exonic variation in inflammatory bowel disease in Scotland: implications for disease pathogenesis. (18563169)	Russell R.K.... Nimmo E.R.	2008	NOD2
12	Mechanisms of action of infliximab in inflammatory bowel disease: an anti-inflammatory multitasker. (18598993)	Danese S.	2008	TNF
13	Comparison of a novel fecal marker--fecal tumor pyruvate kinase type M2 (M2-PK) with fecal calprotectin in patients with inflammatory bowel disease: a prospective study. (19097497)	Shastri Y.M.... Stein J.	2008	PKM
14	Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine. (17941093)	Subramanian S.... Campbell B.J.	2008	IL8
15	Phosphodiesterase 4 inhibitors and inflammatory bowel disease: emerging therapies in inflammatory bowel disease. (17714033)	Keshavarzian A.... Banan A.	2007	PDE4A
16	Fecal lactoferrin is a sensitive and specific marker of disease activity in children and young adults with inflammatory bowel disease. (17414136)	Walker T.R.... Rufo P.A.	2007	LTF
17	Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease. (17255827)	Cucchiara S.... Annese V.	2007	TNF, ABCB1
18	Emerging biological treatments in inflammatory bowel diseases. (17912187)	Van Assche G.... Rutgeerts P.	2007	TNF
19	Identification of colorectal cancer, adenoma, and inflammatory bowel disease specific gene expression patterns using whole genomic oligonucleotide microarray system (17959550)	Galamb O.... Tulassay Z.	2007	CD44, LCN2, UBD
20	IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. (17484863)	Tremelling M.... Satsangi J.	2007	NOD2, IL23R
21	New genes in inflammatory bowel disease: lessons for complex diseases? (16631883)	Gaya D.R.... Satsangi J.	2006	NOD2
22	Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. (16543290)	Hindorf U.... Almer S.	2006	ITPA, TPMT
23	VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. (16293653)	Goebel S.... Kevil C.G.	2006	VEGFA
24	Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. (17058067)	Moehle C.... Schmitz G.	2006	BMP6, MUC2, MUC4
25	Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. (15674109)	Schmidt C.... Stallmach A.	2005	EBI3, IL27
26	Intraperitoneal cytokine productions and their relationship to peritoneal sepsis and systemic inflammatory markers in patients with inflammatory bowel disease. (15785898)	Yamamoto T.... Matsumoto K.	2005	IL6
27	Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease. (15647604)	Van Assche G.... Rutgeerts P.	2005	ITGA4
28	Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy. (15167634)	Derijks L.J.... Hooymans P.M.	2004	TPMT
29	Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease. (15118980)	Cuffari C.... Bayless T.M.	2004	TPMT
30	A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. (14500760)	Froicu M.... Cantorna M.T.	2003	VDR, CYP27B1
31	The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease. (14641539)	Buning C.... Schmidt H.	2003	IL25, C19orf10
32	Immunolocalization and expression of kallistatin and tissue kallikrein in human inflammatory bowel disease. (12757180)	Stadnicki A.... Colman R.W.	2003	SERPINA4
33	Serum human cartilage glycoprotein 39 as a marker of arthritis associated with inflammatory bowel disease. (14644865)	Punzi L.... Sturniolo G.C.	2003	CRP, CHI3L1
34	Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. (14568967)	Bamias G.... Cominelli F.	2003	TNFSF15
35	Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism. (12172211)	Schwab M.... Kaskas B.A.	2002	TPMT
36	Chemokine receptor CXCR3 expression in inflammatory bowel disease. (11720316)	Yuan Y.H.... te Velde A.A.	2001	CXCR3
37	PPARgamma and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease. (11516972)	Wada K.... Blumberg R.S.	2001	PPARG, NR1H2
38	Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease. (10749795)	Xiao Q.... Brubaker P.L.	2000	GCG
39	Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. (10777714)	Rioux J.D.... Siminovitch K.A.	2000	IBD5, IBD3, IBD6
40	Cytokine-targeted therapeutic approaches for inflammatory bowel disease. (12861352)	Mitsuyama K.... Sata M.	2000	IL11
41	Type II 11beta-hydroxysteroid dehydrogenase expressio n in human colonic epithelial cells of inflammatory bowel disease. (10630506)	Takahashi K.I.... Nagura H.	1999	NR3C2
42	Selective COX-2 inhibitors and human inflammatory bowel disease. (10468690)	McCartney S.A.... Warner T.D.	1999	PTGS2
43	Cytokines in inflammatory bowel disease. (9523521)	Rogler G.... Andus T.	1998	IL10, IL11
44	Hemostatic abnormalities in inflammatory bowel disease. (9163067)	Chiarantini E.... Abbate R.	1996	SERPINC1
45	Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease. (8592524)	Schreiber S.... Raedler A.	1996	EPO
46	Modulation of cytokine release from human monocytes by drugs used in the therapy of inflammatory bowel diseases. (7496871)	Bruin K.F.... van Deventer S.J.	1995	TNF, IL6, ALOX5
47	Interleukin-2 receptor alpha and beta chain expression by circulating alpha beta and gamma delta T cells in inflammatory bowel disease. (7851192)	Kirman I.... Brynskov J.	1995	IL2RA
48	PMN-elastase in assessment of patients with inflammatory bowel disease. (8359075)	Andus T.... SchAPlmerich J.	1993	ELANE
49	Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease. (1587185)	Stevens C.... Strom T.B.	1992	TNF, IL6, IL1B
50	Faecal clearance of alpha 1-antitrypsin reflects disease activity and correlates with rapid turnover proteins in chronic inflammatory bowel disease. (1909193)	Miura S.... Tsuchiya M.	1991	TF

Genes related to inflammatory bowel disease according to GeneCards:

(show top 50)    (show all 617)

id	Symbol	Description	Score	GeneCards Section Context
1	ATG16L1	autophagy related 16-like 1 (S. cerevisiae)	11.1	Publications, Summaries
2	NOD2	nucleotide-binding oligomerization domain containing 2	11.1	Aliases & Descriptions, Publications
3	IBD26	Inflammatory bowel disease-26	11.1	Aliases & Descriptions
4	IBD20	Inflammatory bowel disease-20	11.1	Aliases & Descriptions
5	IBD27	Inflammatory bowel disease-27	11.1	Aliases & Descriptions
6	IBD19	Inflammatory bowel disease 19	11.1	Aliases & Descriptions
7	IBD16	Inflammatory bowel disease-16	11.1	Aliases & Descriptions
8	IBD12	Inflammatory bowel disease 12	11.1	Aliases & Descriptions
9	IBD22	Inflammatory bowel disease-22	11.1	Aliases & Descriptions
10	IBD21	Inflammatory bowel disease-21	11.1	Aliases & Descriptions
11	IBD24	Inflammatory bowel disease-24	11.1	Aliases & Descriptions
12	IBD8	inflammatory bowel disease 8	11.1	Aliases & Descriptions
13	IBD11	Inflammatory bowel disease 11	11.1	Aliases & Descriptions
14	IBD9	inflammatory bowel disease 9	11.1	Publications, Aliases & Descriptions
15	IBD6	inflammatory bowel disease 6	11.1	Aliases & Descriptions, Publications
16	IBD3	inflammatory bowel disease 3	11.1	Publications, Aliases & Descriptions
17	IBD4	inflammatory bowel disease 4	11.1	Aliases & Descriptions
18	IBD18	Inflammatory bowel disease-18	11.1	Aliases & Descriptions
19	IBD15	Inflammatory bowel disease-15	11.1	Aliases & Descriptions
20	IBD2	inflammatory bowel disease 2	11.1	Publications, Aliases & Descriptions
21	IBD7	inflammatory bowel disease 7	11.1	Aliases & Descriptions, Publications
22	IBD23	Inflammatory bowel disease-23	11.1	Aliases & Descriptions
23	IBD5	inflammatory bowel disease 5	11.1	Aliases & Descriptions, Publications
24	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.1	Summaries
25	IBD25	Inflammatory bowel disease-25	11.1	Aliases & Descriptions
26	KIF21B	kinesin family member 21B	11.0	Summaries
27	IL23R	interleukin 23 receptor	11.0	Publications
28	IL11	interleukin 11	11.0	Publications
29	IL10RB	interleukin 10 receptor, beta	11.0	Publications
30	IL10RA	interleukin 10 receptor, alpha	11.0	Publications
31	IL10	interleukin 10	11.0	Publications
32	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
33	IGSF6-DREV1	region containing immunoglobulin superfamily, member 6 and DREV1	11.0	Publications
34	IGSF6	immunoglobulin superfamily, member 6	11.0	Publications, UniProt Related
35	TPMT	thiopurine S-methyltransferase	11.0	Publications
36	SLC22A4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4	11.0	Publications
37	SERPINA4	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	11.0	Publications
38	EBI3	Epstein-Barr virus induced 3	11.0	Publications
39	AVIL	advillin	11.0	Publications
40	REG3A	regenerating islet-derived 3 alpha	11.0	Publications
41	MADCAM1	mucosal vascular addressin cell adhesion molecule 1	11.0	Publications
42	ITPA	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	11.0	Publications
43	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	11.0	Publications
44	TFF2	trefoil factor 2	11.0	Publications
45	NOD1	nucleotide-binding oligomerization domain containing 1	11.0	Publications
46	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
47	AQP8	aquaporin 8	11.0	Publications
48	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Publications
49	S100A12	S100 calcium binding protein A12	11.0	Publications
50	METTL9	methyltransferase like 9	11.0	Publications

Pathways related to inflammatory bowel disease according to GeneDecks:

(show top 50)    (show all 176)

id	Pathway	Score	Top Affiliating Genes
1	p53 Mediated Apoptosis36	INF	KIT, BMP6, BMP7, BCL2, ATM, FLT1
2	Chagas disease (American trypanosomiasis)20	INF	RELA, SERPINE1, MYD88, BDKRB2, , JUN
3	Immune response MIF in innate immunity response10	INF	RELA, MYD88, , LBP, JUN, CD14
4	PAK Pathway36	INF	WAS, KIT, MYO9B, BMP6, BMP7, LIF
5	DHA Signaling36	INF	KIT, BMP6, BMP7, BCL2, FLT1, AREG
6	SOCS Pathway36	INF	BMP6, BMP7, BCL2, JAK1, JAK2, CD80
7	Cytokine production by Th17 cells in CF41	INF	RELA, MYD88, , LBP, JAK1, JAK2
8	NF-KappaB (p50-p65) Pathway36	INF	RELA, MYD88, BMP6, BMP7, , UBD
9	PEDF Induced Signaling36	INF	RELA, BRAF, BMP6, BMP7, LIF, BCL2
10	PGC1Alpha Pathway36	INF	BMP6, BMP7, BCL2, CD80, IL10RA, IL10RB
11	TRAF Pathway36	INF	MYD88, , UBD, UBC, JUN, FOS
12	Cytokine-cytokine receptor interaction20	INF	KIT, VEGFA, BMP7, LIF, LEP, CD40LG
13	Mitochondrial Apoptosis36	INF	KIT, BMP6, BMP7, BCL2, ATM, CDKN2A
14	Toll-Like Receptor Signaling Pathways37	INF	RELA, MYD88, , JUN, CD36, CD14
15	RAR-Gamma-RXR-Alpha Degradation36	INF	BMP7, LIF, UBD, UBC, CD80, IL11
16	Molecular Mechanisms of Cancer36	INF	BRCA1, MYC, BMP6, BMP7, LIF, BCL2
17	Glucocorticoid Receptor Signaling36	INF	BMP6, BMP7, BCL2, JUN, CDKN1A, CD80
18	TNF Superfamily Pathway36	INF	, JUN, FOS, MAPK8, MAPK14, MAPK10
19	Toll-Like Receptors Pathway36	INF	MYD88, , LBP, JUN, CD14, IRAK3
20	Th17 Differentiation37	13.3	JAK1, JAK2, CD28, CD86, CD80, IL12B
21	Th1 Differentiation37	12.9	JUN, JAK1, JAK2, CD28, CD86, CD80
22	Influenza A20	12.9	RELA, MYD88, CIITA, JUN, JAK1, JAK2
23	Phagosome20	12.6	SFTPD, MRC1, MPO, CD209, CD36, CD14
24	Leishmaniasis20	12.1	RELA, MYD88, JUN, JAK1, JAK2, ITGA4
25	UPA-UPAR Pathway36	12.0	SERPINE1, LAMB2, LAMC2, JUN, JAK1, JAK2
26	Immune response Oncostatin M signaling via JAK-Stat in human cells10	11.3	JAK1, JAK2, CCL2, CCL11, CCND1, TYK2
27	Autoimmune thyroid disease20	11.2	CD28, CD86, CD40LG, CD80, CD40, GZMB
28	Colorectal Cancer Metastasis36	11.0	BRAF, MYC, MSH2, JAK1, CDKN1A, CDH1
29	Colorectal cancer20	10.2	BRAF, MSH2, FOS, MAPK8, CASP9, SMAD2
30	Immune response_MIF-mediated glucocorticoid regulation41	INF	RELA, VCAM1, , JUN, MMP1, FOS
31	Transendothelial Migration of Leukocytes36	INF	WAS, VCAM1, MYO9B, CLDN2, CLDN4, CLDN1
32	Chemokine Signaling36	INF	JUN, JAK2, FOS, IL8, MAPK8, MAPK14
33	TREM1 Pathway36	INF	BRAF, MYD88, , JUN, FOS, IRAK3
34	Cytokine production by Th17 cells in CF (Mouse model)41	INF	RELA, MYD88, , LBP, JAK2, CD14
35	Inflammasome Activation Pathways37	INF	RELA, MYD88, , JUN, FOS, IL18
36	TGF-Beta Pathway36	INF	BMP6, BMP7, BCL2, JUN, CD80, CDH1
37	Intestinal immune network for IgA production20	INF	, CD28, CD86, CD40LG, CD80, CD40
38	Rho Family GTPases36	INF	KIT, BMP6, BMP7, LIF, BCL2, LAMB2
39	NF-KappaB Family Pathway36	INF	RELA, MYD88, BMP6, BMP7, , IRAK3
40	p38 Signaling36	INF	KIT, BMP6, BMP7, LIF, BCL2,
41	Pathways in cancer20	INF	RELA, VEGFA, MYC, BCL2, , LAMB2
42	MIF Regulation of Innate Immune Cells36	INF	BMP6, BMP7, LIF, BCL2, JUN, CD14
43	Cell adhesion molecules (CAMs)20	INF	SELL, SELP, , CLDN2, CLDN4, CLDN1
44	NFAT Signaling and Lymphocyte Interactions36	INF	BMP6, BMP7, BCL2, CD80, FCER1A, IL11
45	Hepatitis C20	INF	RELA, BRAF, CLDN2, CLDN4, CLDN1,
46	Measles20	INF	RELA, MYD88, , JAK1, JAK2, CD209
47	NFAT in Immune Response36	INF	KIT, BMP6, BMP7, , , JUN
48	Cellular Apoptosis Pathway36	INF	KIT, BMP6, BMP7, BCL2, , ATM
49	Toxoplasmosis20	INF	RELA, MYD88, BCL2, CIITA, , LAMB2
50	p70S6K Signaling36	INF	KIT, BMP6, BMP7, JAK1, JAK2, FLT1

Compounds related to inflammatory bowel disease according to GeneDecks:

(show top 50)    (show all 483)

id	Compound	Score	Top Affiliating Genes
1	sialic acid32	INF	RBP4, SELL, , SERPINA3, NAGLU, LGALS1
2	h2o232	INF	PDE4A, VWF, SELL, SERPINA1, VIP, NAGLU
3	azathioprine32 34 9 9	INF	PCNA, LIF, BGLAP, MUC2, MTHFR, XDH
4	latex32	INF	WAS, VWF, RBP4, , NAGLU, LIF
5	gaba32 42	INF	GCG, VIP, BLVRB, BDKRB2, SCT, CHGA
6	vegf32	INF	PDE4A, RETN, KIT, VWF, PCNA, GCG
7	ccl432	INF	MMP13, IL12B, IL13, IL15, IL16, IL17A
8	5-aza-2deoxycytidine32	INF	SFRP1, PCNA, SERPINB5, BRCA1, MYC, BMP6
9	etoposide32 42 9 9	INF	PCNA, SELE, SETD2, MYC, BCL2, LGALS1
10	simvastatin32 34 42 9 18 9	INF	VWF, RBP4, SELE, SELL, SELP, SERPINE1
11	cocaine32 9 9	INF	PDE4A, GCG, SELE, SELP, VCAM1, BMP6
12	doxorubicin32 34 9 9	INF	KIT, SELE, SETD2, BRCA1, BMP6,
13	12-o-tetradecanoylphorbol 13-acetate32	INF	BRAF, MYC, BMP6, LIF, , MUC2
14	tgf beta132	INF	SETD2, SERPINE1, VCAM1, BMP6, BMP7, LIF
15	homocysteine32 18	13.8	RETN, VWF, SELE, SELP, SERPINC1, SERPINE1
16	cuprophan32	12.7	SELL, SELP, VCAM1, LIF, B2M, CD14
17	vitamin-e32	12.6	RBP4, NAGLU, VCAM1, B2M, JAK2, CD40
18	fluticasone propionate32 42 9 9	15.6	SELE, VCAM1, BGLAP, MPO, MMP9, IL13
19	dextran sulfate32	12.5	SELE, SELL, SELP, SERPINC1, CIITA, MPO
20	flagellin32	12.3	MYD88, S100A8, CD86, IL18, IL1B, IL8
21	guanine32 9 18 9	15.2	VWF, GCG, SELE, SETD2, VIP, BRCA1
22	pravastatin32 34 9 18 9	16.0	SELE, SELP, SERPINE1, ITGAL, IL18, IL6
23	nicotine32 34 9 9	14.4	SELL, FLG, GRP, AOX1, ANXA1, GPT
24	enalapril32 9 9	13.4	SERPINE1, VIP, NAGLU, BMP6, BMP7, IL10
25	prostaglandin f2alpha32	11.3	PDE4A, SERPINE1, VIP, CD44, MMP1, GRP
26	phenobarbital32 9 9	13.1	PCNA, MYC, GUSB, GSTM1, APOA1, GPT
27	p0000132	10.9	SERPINE1, BRAF, MTHFR, S100A8, CDKN1B, CD14
28	ciglitazone32	10.8	SERPINE1, JUN, CDKN1A, CDKN1B, MMP2, MMP9
29	ang ii32	9.8	VEGFA, JAK2, CD36, IL6ST, MAPK8, MAPK10
30	cyclosporin a32 42	INF	PDE4A, VWF, SELP, VIP, NAGLU, VDR
31	ly29400232	INF	RETN, GCG, SELE, VEGFA, LEP,
32	gefitinib32 34 9 9	INF	KIT, SFTPD, GCG, SELP, VEGFA, CDKN1A
33	methylcellulose32	INF	KIT, LIF, CD14, , CDH1, FGF2
34	sulindac32 9 9	INF	PCNA, BCL2, CDKN1A, CDH1, MLH1, APC
35	quercetin32 42 9 18 9	INF	SELE, VCAM1, BCL2, , XDH, JUN
36	phenylalanine32	INF	, CIITA, , JAK1, JAK2, CD28
37	s-nitroso-n-acetylpenicillamine32	INF	XDH, IL1B, IL8, MAPK14, IFNG, IDO1
38	celecoxib32 42 34 9 18 9	INF	PCNA, VEGFA, BCL2, CDKN1A, CDKN1B, CDH1
39	tetracycline32 9 9	INF	VWF, BGLAP, S100A8, CDKN2A, CD40LG, MMP1
40	serine32	INF	, PDE4A, RELA, WARS, WAS, KIT
41	carboplatin32 34 9 9	INF	BRCA1, VEGFA, LIF, BDKRB2, BCL2, CHGA
42	tacrolimus32 34 9 9	INF	PCNA, SERPINE1, NAGLU, VDR, MYC, BMP6
43	phospholipid32	INF	PDE4A, VWF, SFTPD, RBP4, SERPINA1, BPI
44	phosphatidylserine32 9 9	INF	VWF, SELE, , BCL2, LGALS1,
45	troglitazone32 42 9 9	INF	SELE, SERPINE1, VDR, VCAM1, BMP6, BCL2
46	butyrate32	INF	PCNA, GCG, SETD2, VDR, MYC, BMP6
47	cisplatin32 34 9 9	INF	PCNA, SETD2, SERPINB5, NAGLU, BRAF, BRCA1
48	acetylcholine32 9 18 9	INF	PDE4A, VWF, GCG, SERPINA3, VIP, BMP6
49	estrogen32	INF	RETN, VWF, PCNA, GCG, GC, RBP4
50	cytochalasin d32 42	INF	WAS, VWF, SELE, SELL, VCAM1,

Cellular components related to inflammatory bowel disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PDE4A, RELA, WARS, WAS, SFRP1, GC
2	membrane	GO:016020	INF	PDE4A, , VEGFA, BCL2, MUC4, LCT
3	plasma membrane	GO:005886	INF	KIT, KIR2DL1, KIR2DL3, SFRP1, GCG, SELE
4	extracellular space	GO:005615	INF	REG3A, KIT, SFRP1, SFTPD, GCG, GC
5	membrane raft	GO:045121	INF	SELE, CLN3, , JAK2, CD79A, CD24
6	external side of plasma membrane	GO:009897	14.1	KIT, VWF, SELL, SELP, VCAM1, B2M
7	secretory granule	GO:030141	11.8	GCG, VEGFA, CHGA, MPO, IL1B, APOA1
8	platelet alpha granule lumen	GO:031093	9.8	VWF, SERPINA1, SERPINE1, VEGFA, FGB, IGF1
9	cell surface	GO:009986	INF	SFRP1, VEGFA, VCAM1, LGALS1, CD24, CD36
10	extracellular region	GO:005576	INF	, , RETN, RETNLB, VWF, SFTPD
11	integral to plasma membrane	GO:005887	INF	, KIR2DL1, KIR2DL3, SELL, SELP,

Biological processes related to inflammatory bowel disease according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to estradiol stimulus	GO:032355	INF	GC, SERPINA1, VDR, MMP9, , IL1B
2	toll-like receptor 4 signaling pathway	GO:034142	INF	RELA, MYD88, , UBC, JUN, CD14
3	toll-like receptor signaling pathway	GO:002224	INF	RELA, MYD88, , UBC, JUN, CD86
4	MyD88-dependent toll-like receptor signaling pathway	GO:002755	INF	RELA, MYD88, , UBC, JUN, FOS
5	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	INF	MYC, , XDH, JAK2, CDKN1B, CDKN2A
6	Toll signaling pathway	GO:008063	INF	RELA, MYD88, , UBC, LBP, JUN
7	negative regulation of cell proliferation	GO:008285	INF	WARS, SFRP1, VDR, LIF, BDKRB2, KAT2B
8	inflammatory response	GO:006954	INF	RELA, KIT, SELE, SELP, SERPINA3, MYD88
9	induction of apoptosis	GO:006917	INF	, CDKN1B, CDKN2A, IRF1, INHBA, IL19
10	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	RELA, SERPINE1, BRCA1, VEGFA, VDR, MYC
11	innate immune response	GO:045087	INF	RELA, SFTPD, MYD88, BCL2, LGALS3,
12	cytokine-mediated signaling pathway	GO:019221	14.2	RELA, KIT, VCAM1, MYD88, CIITA, UBC
13	positive regulation of tumor necrosis factor production	GO:032760	12.9	MYD88, LBP, JAK2, CD36, CD14, IL12B
14	positive regulation of inflammatory response	GO:050729	12.8	SERPINE1, JAK2, IL12B, IL15, IL18, IL2
15	regulation of immune response	GO:050776	12.6	KIR2DL1, KIR2DL3, SELL, VCAM1, B2M, CD8A
16	positive regulation of interleukin-12 production	GO:032735	12.4	CD36, CD40LG, CD40, IL12B, IL23A, IL23R
17	positive regulation of interleukin-6 production	GO:032755	12.4	MYD88, LBP, CD36, IL1A, IL1B, IL33
18	interferon-gamma-mediated signaling pathway	GO:060333	12.3	VCAM1, CIITA, B2M, JAK1, JAK2, CD44
19	positive regulation of cell proliferation	GO:008284	12.1	KIT, SFRP1, VIP, VIPR1, NAMPT, VEGFA
20	response to hypoxia	GO:001666	12.1	SERPINA1, VEGFA, VCAM1, BCL2, LEP, LCT
21	negative regulation of growth of symbiont in host	GO:044130	11.9	MYD88, LBP, CD36, IL10, IL12B, MBL2
22	positive regulation of smooth muscle cell proliferation	GO:048661	11.7	MYD88, JUN, FLT1, IL13, IL6, IL6R
23	positive regulation of angiogenesis	GO:045766	11.7	SERPINE1, VEGFA, CHI3L1, MMP9, FLT1, FGF2
24	positive regulation of cell migration	GO:030335	11.6	VIL1, VEGFA, JAK2, ITGAV, MMP14, FLT1
25	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	11.0	KIT, SELP, JAK2, FLT1, ANGPT1, CCL5
26	anti-apoptosis	GO:006916	10.9	RELA, VIMP, BRAF, MYD88, BCL2, MUC1
27	platelet degranulation	GO:002576	10.7	VWF, SELP, SERPINA1, SERPINE1, VEGFA, CD36
28	response to estrogen stimulus	GO:043627	10.7	SERPINE1, BRCA1, BGLAP, BCL2, LCT, CD24
29	immune response	GO:006955	INF	WAS, KIR2DL1, KIR2DL3, VIPR1, BPI, BMP6
30	blood coagulation	GO:007596	INF	WAS, VWF, SELL, SELP, , SERPINC1
31	platelet activation	GO:030168	INF	VWF, SELP, SERPINA1, SERPINE1, VEGFA,
32	positive regulation of transcription, DNA-dependent	GO:045893	INF	RELA, SFRP1, BRCA1, MYC, BMP7, CIITA
33	cellular response to mechanical stimulus	GO:071260	INF	MYD88, CD40, IRF1, IL13, IL18, IL1B
34	cell-cell signaling	GO:007267	INF	NAMPT, S100A9, CEACAM6, CD86, CD80, ITGB2
35	response to ethanol	GO:045471	INF	RBP4, BGLAP, BCL2, LCT, S100A8, S100A9
36	negative regulation of apoptotic process	GO:043066	INF	RELA, SFRP1, GCG, SERPINE1, BRAF, VEGFA
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	INF	RELA, MYD88, , UBC, CD40, IRAK3
38	signal transduction	GO:007165	INF	PDE4A, KIT, GCG, NAMPT, VDR, MYD88
39	positive regulation of ERK1 and ERK2 cascade	GO:070374	INF	GCG, BRAF, CHI3L1, CD44, MIF,
40	cell surface receptor signaling pathway	GO:007166	INF	MYD88, BDKRB2, CD28, CD36, CD14,
41	chemotaxis	GO:006935	INF	S100A8, S100A9, FGF2, IL4, MAPK14, MAPK1
42	activation of MAPK activity	GO:000187	INF	KIT, UBC, , FGF2, IL1B, MAPK14
43	lipopolysaccharide-mediated signaling pathway	GO:031663	INF	MYD88, LBP, IL18, IL1B, MAPK14, CCL2
44	response to lipopolysaccharide	GO:032496	INF	SELE, SELP, SERPINA1, BDKRB1, LBP, S100A8
45	response to drug	GO:042493	INF	PDE4A, SFRP1, MYC, BGLAP, BDKRB2, BCL2
46	leukocyte migration	GO:050900	INF	SELL, SELP, , , YES1, ITGA4
47	response to organic cyclic compound	GO:014070	INF	SFRP1, SELP, SERPINA1, MSH2, JUN, CDKN1A
48	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	INF	VEGFA, LIF, JAK2, CD36, CD80, CD44
49	cell adhesion	GO:007155	INF	VWF, SELL, SELP, , VCAM1, CLDN1
50	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	INF	RELA, MYD88, LGALS1, , UBD, UBC

Molecular functions related to inflammatory bowel disease according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	SLC9A3, GATA4, GAP43, GAPDH, MYH9, EPO
2	hormone activity	GO:005179	INF	GH1, PYY, PTH, SST, CRH, EDN1
3	protease binding	GO:002020	10.6	IL1R1, F3, TP53, TNF, TNFRSF1A, ELANE
4	chemokine activity	GO:008009	INF	CCL20, , , CCL3, CCL24, CCL5
5	cytokine activity	GO:005125	INF	NAMPT, VEGFA, BMP6, BMP7, LIF, CD40LG
6	heparin binding	GO:008201	INF	SELL, SELP, SERPINC1, VEGFA, LAMC2, MPO
7	receptor binding	GO:005102	INF	ITGB7, ITLN1, , MIF, AR, FGB
8	receptor activity	GO:004872	INF	ABP1, , TEK, TNFRSF6B, TNFRSF11B, TNFRSF11A
9	protein homodimerization activity	GO:042803	INF	TGFB1, DPP4, STAT1, SOD1, CSF1, PON1
10	growth factor activity	GO:008083	INF	F2, HGF, GH1, CTGF, NGF, PDGFA