MCID: INF071
MIFTS: 40

Inflammatory Bowel Disease 1 malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Blood diseases categories

Summaries for Inflammatory Bowel Disease 1

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MalaCards based summary: Inflammatory Bowel Disease 1, also known as crohn disease-associated growth failure, is related to inflammatory bowel disease and classic kaposi sarcoma, and has symptoms including heterogeneous, multifactorial inheritance and weight loss. An important gene associated with Inflammatory Bowel Disease 1 is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and Leishmaniasis. The drugs azathioprine and cholecalciferol and the compounds pha 665752 and su 11274 have been mentioned in the context of this disorder.

Description from OMIM:45 266600

Aliases & Classifications for Inflammatory Bowel Disease 1

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Inflammatory Bowel Disease 1, Aliases & Descriptions:

Name: Inflammatory Bowel Disease 1 45 22
Crohn Disease-Associated Growth Failure 45 10
 
Crohn Disease 60


Classifications:



External Ids:

OMIM45 266600

Related Diseases for Inflammatory Bowel Disease 1

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Graphical network of diseases related to Inflammatory Bowel Disease 1:



Diseases related to inflammatory bowel disease 1

Symptoms for Inflammatory Bowel Disease 1

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Symptoms by clinical synopsis from OMIM:

266600

Clinical features from OMIM:

266600

HPO human phenotypes related to Inflammatory Bowel Disease 1:

(show all 7)
id Description Frequency HPO Source Accession
1 heterogeneous HP:0001425
2 multifactorial inheritance HP:0001426
3 weight loss HP:0001824
4 diarrhea HP:0002014
5 abdominal pain HP:0002027
6 intestinal obstruction HP:0005214
7 recurrent aphthous stomatitis HP:0011107

Drugs & Therapeutics for Inflammatory Bowel Disease 1

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Drug clinical trials:

Search ClinicalTrials for Inflammatory Bowel Disease 1

Search NIH Clinical Center for Inflammatory Bowel Disease 1

Inferred drug relations via UMLS60/NDF-RT39:

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Genetic Tests for Inflammatory Bowel Disease 1

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Genetic tests related to Inflammatory Bowel Disease 1:

id Genetic test Affiliating Genes
1 Inflammatory Bowel Disease 122

Anatomical Context for Inflammatory Bowel Disease 1

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Animal Models for Inflammatory Bowel Disease 1 or affiliated genes

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Publications for Inflammatory Bowel Disease 1

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Articles related to Inflammatory Bowel Disease 1:

idTitleAuthorsYear
1
The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (11132146)
2000
2
Inflammatory bowel disease. 1: Aetiology and pathogenesis. (10670307)
1999
3
Inflammatory bowel disease. 1. Origins, presentation, and course. (9590987)
1998
4
Inflammatory bowel disease (1) (1881418)
1991

Variations for Inflammatory Bowel Disease 1

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Expression for genes affiliated with Inflammatory Bowel Disease 1

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 1.

Pathways for genes affiliated with Inflammatory Bowel Disease 1

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Pathways related to Inflammatory Bowel Disease 1 according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5NOD2, IL6
2
Show member pathways
9.5IL6, NOD2
39.5NOD2, IL6
4
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.5NOD2, IL6
5
Show member pathways
9.5NOD2, IL6
69.5IL6, NOD2
7
Show member pathways
9.5NOD2, IL6
89.5HGF, IL6
9
Show member pathways
9.1IL6, HGF, NOD2
10
Show member pathways
9.1NOD2, HGF, IL6

Compounds for genes affiliated with Inflammatory Bowel Disease 1

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Compounds related to Inflammatory Bowel Disease 1 according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1pha 665752599.9HGF, IL6
2su 11274599.8HGF, IL6
3pf 04217903 mesylate599.8HGF, IL6
4il 10439.8IL6, NOD2
5rebamipide439.8IL6, HGF
6infliximab43 49 1211.8NOD2, IL6
7filgrastim43 1210.8IL6, HGF
8peptidoglycan43 2810.8IL6, NOD2
9crizotinib59 4910.8IL6, HGF
10pmma439.8HGF, IL6
11dextran sulfate439.8IL6, HGF
12pdtc439.7HGF, IL6
13pge1439.7HGF, IL6
14aprotinin43 1210.7IL6, HGF
15thalidomide43 49 59 1212.7HGF, IL6
16sp 60012543 5910.6HGF, IL6
17hydrocortisone43 2 59 1212.6IL6, HGF
18tacrolimus43 49 1211.6NOD2, HGF
19tgf beta1439.6HGF, IL6
20herbimycin a43 5910.5HGF, IL6
21prednisolone43 28 1211.4NOD2, HGF, IL6
22hyaluronic acid43 2410.4IL6, HGF
23endotoxin439.2NOD2, IL6

GO Terms for genes affiliated with Inflammatory Bowel Disease 1

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Biological processes related to Inflammatory Bowel Disease 1 according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell activationGO:00508719.8NOD2, IL6
2defense response to Gram-positive bacteriumGO:00508309.8NOD2, IL6
3positive regulation of interleukin-6 productionGO:00327559.8IL6, NOD2
4activation of MAPK activityGO:00001879.7NOD2, HGF
5positive regulation of epithelial cell proliferationGO:00506799.7NOD2, IL6
6positive regulation of osteoblast differentiationGO:00456699.7HGF, IL6
7negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.6IL6, HGF
8positive regulation of ERK1 and ERK2 cascadeGO:00703749.6NOD2, IL6
9platelet activationGO:00301689.5HGF, IL6
10response to lipopolysaccharideGO:00324969.4NOD2, IL6
11positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4NOD2, HGF, IL6
12positive regulation of NF-kappaB transcription factor activityGO:00510929.2NOD2, IL6
13positive regulation of transcription from RNA polymerase II promoterGO:00459449.1IL6, HGF, NOD2

Molecular functions related to Inflammatory Bowel Disease 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.5HGF, IL6

Products for genes affiliated with Inflammatory Bowel Disease 1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Inflammatory Bowel Disease 1

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet