MCID: INF071
MIFTS: 44

Inflammatory Bowel Disease 1 malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Blood diseases categories

Summaries for Inflammatory Bowel Disease 1

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MalaCards based summary: Inflammatory Bowel Disease 1, also known as crohn disease-associated growth failure, is related to inflammatory bowel disease and classic kaposi sarcoma, and has symptoms including heterogeneous, multifactorial inheritance and weight loss. An important gene associated with Inflammatory Bowel Disease 1 is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and Leishmaniasis. The drugs azathioprine and thalidomide and the compounds pha 665752 and su 11274 have been mentioned in the context of this disorder.

Description from OMIM:47 266600

Aliases & Classifications for Inflammatory Bowel Disease 1

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Inflammatory Bowel Disease 1, Aliases & Descriptions:

Name: Inflammatory Bowel Disease 1 47 24 62
 
Crohn Disease-Associated Growth Failure 47 11


Classifications:



External Ids:

OMIM47 266600

Related Diseases for Inflammatory Bowel Disease 1

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Graphical network of diseases related to Inflammatory Bowel Disease 1:



Diseases related to inflammatory bowel disease 1

Symptoms for Inflammatory Bowel Disease 1

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Symptoms by clinical synopsis from OMIM:

266600

Clinical features from OMIM:

266600

HPO human phenotypes related to Inflammatory Bowel Disease 1:

(show all 7)
id Description Frequency HPO Source Accession
1 heterogeneous HP:0001425
2 multifactorial inheritance HP:0001426
3 weight loss HP:0001824
4 diarrhea HP:0002014
5 abdominal pain HP:0002027
6 intestinal obstruction HP:0005214
7 recurrent aphthous stomatitis HP:0011107

Drugs & Therapeutics for Inflammatory Bowel Disease 1

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Drug clinical trials:

Search ClinicalTrials for Inflammatory Bowel Disease 1

Search NIH Clinical Center for Inflammatory Bowel Disease 1

Inferred drug relations via UMLS62/NDF-RT41:

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Genetic Tests for Inflammatory Bowel Disease 1

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Genetic tests related to Inflammatory Bowel Disease 1:

id Genetic test Affiliating Genes
1 Inflammatory Bowel Disease 124

Anatomical Context for Inflammatory Bowel Disease 1

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Animal Models for Inflammatory Bowel Disease 1 or affiliated genes

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Publications for Inflammatory Bowel Disease 1

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Articles related to Inflammatory Bowel Disease 1:

idTitleAuthorsYear
1
The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (11132146)
2000
2
Inflammatory bowel disease. 1: Aetiology and pathogenesis. (10670307)
1999
3
Inflammatory bowel disease. 1. Origins, presentation, and course. (9590987)
1998
4
Inflammatory bowel disease (1) (1881418)
1991

Variations for Inflammatory Bowel Disease 1

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Expression for genes affiliated with Inflammatory Bowel Disease 1

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 1.

Pathways for genes affiliated with Inflammatory Bowel Disease 1

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Pathways related to Inflammatory Bowel Disease 1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5NOD2, IL6
2
Show member pathways
9.5IL6, NOD2
39.5NOD2, IL6
4
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.5NOD2, IL6
5
Show member pathways
9.5NOD2, IL6
69.5IL6, NOD2
7
Show member pathways
9.5NOD2, IL6
89.5HGF, IL6
9
Show member pathways
9.1IL6, HGF, NOD2
10
Show member pathways
9.1NOD2, HGF, IL6

Compounds for genes affiliated with Inflammatory Bowel Disease 1

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Compounds related to Inflammatory Bowel Disease 1 according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1pha 665752619.9HGF, IL6
2su 11274619.8HGF, IL6
3pf 04217903 mesylate619.8HGF, IL6
4il 10459.8IL6, NOD2
5rebamipide459.8IL6, HGF
6infliximab45 51 1311.8NOD2, IL6
7filgrastim45 1310.8IL6, HGF
8peptidoglycan45 3010.8IL6, NOD2
9crizotinib61 5110.8IL6, HGF
10pmma459.8HGF, IL6
11dextran sulfate459.8IL6, HGF
12pdtc459.7HGF, IL6
13pge1459.7HGF, IL6
14aprotinin45 1310.7IL6, HGF
15thalidomide45 51 61 1312.7HGF, IL6
16sp 60012545 6110.6HGF, IL6
17hydrocortisone45 3 61 1312.6IL6, HGF
18tacrolimus45 51 1311.6NOD2, HGF
19tgf beta1459.6HGF, IL6
20herbimycin a45 6110.5HGF, IL6
21prednisolone45 30 1311.4NOD2, HGF, IL6
22hyaluronic acid45 2610.4IL6, HGF
23endotoxin459.2NOD2, IL6

GO Terms for genes affiliated with Inflammatory Bowel Disease 1

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Biological processes related to Inflammatory Bowel Disease 1 according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell activationGO:00508719.8NOD2, IL6
2defense response to Gram-positive bacteriumGO:00508309.8NOD2, IL6
3positive regulation of interleukin-6 productionGO:00327559.8IL6, NOD2
4activation of MAPK activityGO:00001879.7NOD2, HGF
5positive regulation of epithelial cell proliferationGO:00506799.7NOD2, IL6
6positive regulation of osteoblast differentiationGO:00456699.7HGF, IL6
7negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.6IL6, HGF
8positive regulation of ERK1 and ERK2 cascadeGO:00703749.6NOD2, IL6
9platelet activationGO:00301689.5HGF, IL6
10response to lipopolysaccharideGO:00324969.4NOD2, IL6
11positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4NOD2, HGF, IL6
12positive regulation of NF-kappaB transcription factor activityGO:00510929.2NOD2, IL6
13positive regulation of transcription from RNA polymerase II promoterGO:00459449.1IL6, HGF, NOD2

Molecular functions related to Inflammatory Bowel Disease 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.5HGF, IL6

Products for genes affiliated with Inflammatory Bowel Disease 1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Inflammatory Bowel Disease 1

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet