IBD4
MCID: INF087
MIFTS: 40

Inflammatory Bowel Disease 4 (IBD4) malady

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases, Bone diseases, Blood diseases, Immune diseases

Aliases & Classifications for Inflammatory Bowel Disease 4

Aliases & Descriptions for Inflammatory Bowel Disease 4:

Name: Inflammatory Bowel Disease 4 54 12 13 14 69
Ibd4 12

Classifications:



External Ids:

OMIM 54 606675
Disease Ontology 12 DOID:0110903

Summaries for Inflammatory Bowel Disease 4

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 14q11-q12.

MalaCards based summary : Inflammatory Bowel Disease 4, also known as ibd4, is related to amelogenesis imperfecta 1j and appendix carcinoid tumor. An important gene associated with Inflammatory Bowel Disease 4 is IBD4 (Inflammatory Bowel Disease 4), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Infliximab and Benzocaine have been mentioned in the context of this disorder. Related phenotypes are digestive/alimentary and immune system

Description from OMIM: 606675

Related Diseases for Inflammatory Bowel Disease 4

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 23
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 12 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 5 Inflammatory Bowel Disease 19
Inflammatory Bowel Disease 3 Inflammatory Bowel Disease 13
Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 16 Inflammatory Bowel Disease 15
Inflammatory Bowel Disease 20 Inflammatory Bowel Disease 28, Early Onset, Autosomal Recessive
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 4
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 22 Inflammatory Bowel Disease 21
Inflammatory Bowel Disease 6 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive Il21-Related Infantile Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta 1j 10.3 EPX RNASE3
2 appendix carcinoid tumor 10.2 EPX RNASE3
3 chemical colitis 10.2 EPX RNASE3
4 microphthalmia, isolated 7 10.2 HOGA1 NOD2
5 anterior dislocation of lens 10.2 IL4 RNASE3
6 sarcoma 10.2 IL4 KIT
7 sarcoidosis, early-onset 10.2 HOGA1 NOD2
8 scalp dermatosis 10.1 EPX RNASE3
9 restrictive cardiomyopathy 10.1 IL5 RNASE3
10 crustacean allergy 10.1 IL13 IL4
11 kahrizi syndrome 10.1 IL5 KIT
12 central nervous system origin vertigo 10.1 EPX IL4 RNASE3
13 brown shrimp allergy 10.1 IL5 RNASE3
14 goat milk allergy 10.1 IL13 IL4
15 latent syphilis 10.0 IL5 RNASE3
16 benign meningioma 10.0 IL5 RNASE3
17 infectious anterior uveitis 10.0 IL5 RNASE3
18 psoriatic arthritis 10.0 HOGA1 NOD2 NPL
19 papillary squamous carcinoma 10.0 IL4 IL5
20 hypersensitivity vasculitis 10.0 IL4 IL5
21 allescheriosis 10.0 IL4 IL5
22 dahlberg borer newcomer syndrome 10.0 IL13 IL5
23 urethral intrinsic sphincter deficiency 10.0 IL4 IL5
24 aortic atherosclerosis 10.0 IL13 IL5
25 hypercementosis 10.0 IL13 IL5
26 necrotizing gastritis 10.0 EPX IL5 RNASE3
27 may-thurner syndrome 9.9 IL13 KIT
28 breast intracanalicular fibroadenoma 9.9 IL4 IL5
29 bile duct signet ring cell carcinoma 9.9 IL5 RNASE3
30 spastic diplegia 9.9 IL13 IL5
31 exudative vitreoretinopathy 2, x-linked 9.9 IL13 IL5
32 cutaneous fibrous histiocytoma 9.9 IL4 IL5
33 histoplasmosis retinitis 9.9 IL4 IL5
34 disordered steroidogenesis due to cytochrome p450 oxidoreductase 9.9 IL13 IL5
35 small intestine lymphoma 9.9 IL5 RNASE3
36 marasmus 9.9 IL4 IL5 RNASE3
37 lens-induced iridocyclitis 9.9 IL4 IL5 RNASE3
38 isolated klippel-feil syndrome 9.9 IL4 IL5
39 multiple epiphyseal dysplasia due to collagen 9 anomaly 9.9 IL4 IL5 RNASE3
40 cerebral primitive neuroectodermal tumor 9.9 IL4 IL5 RNASE3
41 apricot allergy 9.9 IL4 IL5 RNASE3
42 orbit alveolar rhabdomyosarcoma 9.9 IL4 IL5 RNASE3
43 smooth muscle tumor 9.9 IL13 IL5
44 prostate small cell carcinoma 9.9 IL13 IL5
45 dissociated nystagmus 9.9 EPX IL4 IL5
46 renal hypertension 9.9 IL13 IL5 RNASE3
47 childhood malignant mesenchymoma 9.8 IL13 IL5 RNASE3
48 coenurosis 9.8 IL4 IL5
49 thelaziasis 9.8 IL13 IL4 IL5
50 lymphoblastic leukemia 9.8 IL13 IL4 IL5

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 4:



Diseases related to Inflammatory Bowel Disease 4

Symptoms & Phenotypes for Inflammatory Bowel Disease 4

Clinical features from OMIM:

606675

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 4:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL13 IL4 IL5 KIT NOD2
2 immune system MP:0005387 9.17 IL5 KIT NOD2 NPL EPX IL13

Drugs & Therapeutics for Inflammatory Bowel Disease 4

Drugs for Inflammatory Bowel Disease 4 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 586)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 3,Phase 2 170277-31-3
2
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
3
Clarithromycin Approved Phase 4,Phase 3,Phase 1 81103-11-9 84029
4
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
5
Rifabutin Approved Phase 4,Phase 3 72559-06-9 6323490
6
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
7
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
9
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
12
Sulfamethazine Approved, Vet_approved Phase 4 57-68-1 5327
13
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
14
Sucralfate Approved Phase 4 54182-58-0
15
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
16
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 169590-42-5 2662
17 Parecoxib Approved Phase 4 198470-84-7
18
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
19
Azathioprine Approved Phase 4,Phase 3 446-86-6 2265
20
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
21
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
22
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 2 73590-58-6 4594
23
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
24
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 53-86-1 3715
25
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2 103577-45-3 3883
26
Metformin Approved Phase 4,Phase 2 657-24-9 14219 4091
27
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
28
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 65-49-6 4649
29
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
30
Doxorubicin Approved, Investigational Phase 4,Phase 1,Phase 2 23214-92-8 31703
31
Vincristine Approved, Investigational Phase 4,Phase 1,Phase 2 2068-78-2, 57-22-7 5978
32
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
33
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
34
Rosiglitazone Approved, Investigational Phase 4,Phase 2 122320-73-4 77999
35
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
36
Dopamine Approved Phase 4,Phase 1,Phase 2 51-61-6, 62-31-7 681
37
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
39
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2 2078-54-8 4943
40
Lubiprostone Approved, Investigational Phase 4 136790-76-6 656719
41
Ibuprofen Approved Phase 4 15687-27-1 3672
42
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
43
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
44
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
45
Metronidazole Approved Phase 4,Phase 3,Phase 1 443-48-1 4173
46
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
47
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
48
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
49
Natalizumab Approved, Investigational Phase 4 189261-10-7
50
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474

Interventional clinical trials:

(show top 50) (show all 839)
id Name Status NCT ID Phase
1 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4
3 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
4 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
5 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4
6 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4
7 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
8 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4
9 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
10 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4
11 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4
12 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
13 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
14 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4
15 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
16 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4
17 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4
18 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4
19 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4
20 Enhanced Algorithm for Crohn's Treatment Incorporating Early Combination Therapy Unknown status NCT01698307 Phase 4
21 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4
22 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4
23 Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia Unknown status NCT01789294 Phase 4
24 ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial Unknown status NCT02016807 Phase 4
25 Rifaximin Predicts the Complications of Decompensated Cirrhosis Unknown status NCT02074280 Phase 4
26 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4
27 Low Volume Colon Preparation for IBD Completed NCT02248337 Phase 4
28 Gene Regulation by Thiazolidinediones Completed NCT00567593 Phase 4
29 Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease Completed NCT01981889 Phase 4
30 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
31 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4
32 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed NCT01034358 Phase 4
33 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease Completed NCT02162862 Phase 4
34 Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI) Completed NCT02437591 Phase 4
35 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4
36 Immunogenicity of Hepatitis A Vaccine in Inflammatory Bowel Disease (IBD) Patients Completed NCT01341808 Phase 4
37 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
38 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4
39 Satisfaction With Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl Sedation for Endoscopy Completed NCT01934088 Phase 4
40 Randomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy Completed NCT00746395 Phase 4
41 Treatment of Ulcerative Colitis With Ciprofloxacin and E. Coli Nissle Completed NCT01772615 Phase 4
42 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4
43 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
44 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
45 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
46 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
47 Dose Escalation and Remission (DEAR) Completed NCT00652145 Phase 4
48 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4
49 Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole Completed NCT00640809 Phase 4
50 Intragastric and Peritoneal Microdialysis in Infants With Necrotizing Enterocolitis (NEC) Completed NCT00332592 Phase 4

Search NIH Clinical Center for Inflammatory Bowel Disease 4

Genetic Tests for Inflammatory Bowel Disease 4

Anatomical Context for Inflammatory Bowel Disease 4

Publications for Inflammatory Bowel Disease 4

Articles related to Inflammatory Bowel Disease 4:

id Title Authors Year
1
Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed. ( 23197886 )
2012

Variations for Inflammatory Bowel Disease 4

Expression for Inflammatory Bowel Disease 4

Search GEO for disease gene expression data for Inflammatory Bowel Disease 4.

Pathways for Inflammatory Bowel Disease 4

Pathways related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 IL13 IL4 IL5 KIT NOD2
2
Show member pathways
12.54 EPX IL13 IL4 IL5 RNASE3
3
Show member pathways
12.33 IL13 IL4 IL5 NOD2
4
Show member pathways
12.08 IL13 IL4 IL5
5
Show member pathways
11.95 IL13 IL4 IL5
6
Show member pathways
11.91 IL13 IL4 IL5
7 11.75 IL4 IL5 KIT
8 11.64 IL4 IL5 KIT
9 11.55 IL13 IL4 IL5
10 11.41 IL13 IL4 IL5
11 11.22 IL13 IL4 IL5
12 11.08 IL4 IL5
13 11 IL13 IL4 IL5
14 10.95 IL13 IL4 IL5
15 10.91 IL13 IL4 IL5
16 10.83 IL13 IL4 IL5 KIT
17 10.75 IL13 IL4 IL5
18 10.31 IL13 IL4 IL5

GO Terms for Inflammatory Bowel Disease 4

Cellular components related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 IL13 IL4 KIT
2 extracellular space GO:0005615 9.1 EPX IL13 IL4 IL5 KIT RNASE3

Biological processes related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.78 IL4 IL5 KIT NOD2
2 positive regulation of Notch signaling pathway GO:0045747 9.55 KIT NOD2
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.54 KIT NOD2
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.54 IL4 IL5 KIT
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.52 IL13 IL4
6 innate immune response in mucosa GO:0002227 9.51 IL4 RNASE3
7 positive regulation of interleukin-10 production GO:0032733 9.49 IL4 NOD2
8 positive regulation of JAK-STAT cascade GO:0046427 9.46 IL5 KIT
9 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.43 IL4 KIT
10 microglial cell activation GO:0001774 9.4 IL13 IL4
11 positive regulation of mast cell degranulation GO:0043306 9.32 IL13 IL4
12 positive regulation of immunoglobulin production GO:0002639 9.26 IL13 IL4
13 regulation of proton transport GO:0010155 9.16 IL13 IL4
14 negative regulation of complement-dependent cytotoxicity GO:1903660 8.96 IL13 IL4
15 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.62 IL13 IL4

Sources for Inflammatory Bowel Disease 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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