MCID: INF087
MIFTS: 41

Inflammatory Bowel Disease 4

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases, Bone diseases, Blood diseases, Immune diseases

Aliases & Classifications for Inflammatory Bowel Disease 4

MalaCards integrated aliases for Inflammatory Bowel Disease 4:

Name: Inflammatory Bowel Disease 4 54 12 13 14 69
Ibd4 12

Classifications:



External Ids:

OMIM 54 606675
Disease Ontology 12 DOID:0110903

Summaries for Inflammatory Bowel Disease 4

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 14q11-q12.

MalaCards based summary : Inflammatory Bowel Disease 4, also known as ibd4, is related to primary syringomyelia and cecum adenoma. An important gene associated with Inflammatory Bowel Disease 4 is IBD4 (Inflammatory Bowel Disease 4), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Infliximab and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and testes, and related phenotypes are digestive/alimentary and immune system

Description from OMIM: 606675

Related Diseases for Inflammatory Bowel Disease 4

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 23
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 12 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 5 Inflammatory Bowel Disease 19
Inflammatory Bowel Disease 3 Inflammatory Bowel Disease 13
Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 16 Inflammatory Bowel Disease 15
Inflammatory Bowel Disease 20 Inflammatory Bowel Disease 28, Early Onset, Autosomal Recessive
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 4
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 24 Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive

Diseases related to Inflammatory Bowel Disease 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 primary syringomyelia 10.6 EPX RNASE3
2 cecum adenoma 10.6 EPX RNASE3
3 clostridium difficile colitis 10.5 EPX RNASE3
4 anterior dislocation of lens 10.4 IL4 RNASE3
5 klippel-feil syndrome 3, autosomal dominant 10.4 HOGA1 NOD2
6 facial dermatosis 10.3 EPX RNASE3
7 papillary follicular thyroid adenocarcinoma 10.1 IL5 RNASE3
8 goat milk allergy 10.1 IL13 IL4
9 crustacean allergy 10.1 IL5 RNASE3
10 wilms tumor 6 10.1 IL5 KIT
11 central nervous system origin vertigo 10.1 EPX IL4 RNASE3
12 cow milk allergy 10.1 IL13 IL4
13 subacute bacterial endocarditis 10.1 IL5 RNASE3
14 cannabis abuse 10.1 IL5 RNASE3
15 exophthalmos 10.1 IL5 RNASE3
16 signet ring cell adenocarcinoma 10.0 IL5 RNASE3
17 skin disease 10.0 IL5 RNASE3
18 saethre-chotzen syndrome 10.0 HOGA1 NOD2 NPL
19 acute monoblastic leukemia 9.9 IL4 NOD2
20 deafness, autosomal recessive 67 9.9 HOGA1 NOD2 NPL
21 orbit alveolar rhabdomyosarcoma 9.9 IL4 IL5
22 angioid streaks of choroid 9.9 IL4 IL5
23 allescheriosis 9.9 IL4 IL5
24 urethral intrinsic sphincter deficiency 9.9 IL4 IL5
25 whistling face syndrome, recessive form 9.9 IL5 RNASE3
26 histoplasmosis retinitis 9.9 IL4 IL5
27 cytoplasmic body myopathy 9.9 IL13 IL5
28 aortic arch interruption 9.8 IL13 IL5
29 hypercementosis 9.8 IL13 IL5
30 hypothyroidism due to deficient transcription factors involved in pituitary development or function 9.8 IL4 IL5
31 lymphocytic gastritis 9.8 EPX IL5 RNASE3
32 queensland tick typhus 9.8 IL5 NOD2
33 fibrous histiocytoma 9.8 IL4 IL5
34 cholesteatoma of middle ear 9.8 IL13 IL5
35 myofibroma 9.8 IL13 IL5
36 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 9.8 IL13 IL5
37 philophthalmiasis 9.8 IL4 IL5
38 exudative vitreoretinopathy 2, x-linked 9.7 IL13 IL5
39 esophagus small cell carcinoma 9.7 IL13 IL5
40 glioblastoma multiforme 9.7 IL5 RNASE3
41 epidermolysis bullosa simplex superficialis 9.7 IL4 RNASE3
42 inflammatory bowel disease 9.7
43 marasmus 9.7 IL4 IL5 RNASE3
44 x-linked intellectual disability, van esch type 9.7 IL4 IL5 RNASE3
45 orbital plasma cell granuloma 9.7 IL4 IL5 RNASE3
46 apple allergy 9.7 IL4 IL5 RNASE3
47 female urethral cancer 9.7 IL4 IL5 RNASE3
48 nut allergy 9.7 IL4 IL5 RNASE3
49 colon adenocarcinoma 9.6 IL4 IL5 RNASE3
50 myofascial pain syndrome 9.6 IL13 IL5

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 4:



Diseases related to Inflammatory Bowel Disease 4

Symptoms & Phenotypes for Inflammatory Bowel Disease 4

Clinical features from OMIM:

606675

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 4:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL13 IL4 IL5 KIT NOD2
2 immune system MP:0005387 9.17 EPX IL13 IL4 IL5 KIT NOD2

Drugs & Therapeutics for Inflammatory Bowel Disease 4

Drugs for Inflammatory Bowel Disease 4 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 324)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 3,Phase 2 170277-31-3
2
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
5
Rifabutin Approved Phase 4 72559-06-9 6323490
6
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
7
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
9
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
12
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
13
Azathioprine Approved Phase 4,Phase 3 446-86-6 2265
14
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 65-49-6 4649
15
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
16
Rosiglitazone Approved, Investigational Phase 4,Phase 2 122320-73-4 77999
17
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
18
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
20
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
21
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
22
Lubiprostone Approved, Investigational Phase 4 136790-76-6 656719
23
Ciprofloxacin Approved, Investigational Phase 4,Phase 2 85721-33-1 2764
24
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
25
Ibuprofen Approved Phase 4 15687-27-1 3672
26
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1 73590-58-6 4594
27
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
28
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
29
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
30
Metronidazole Approved Phase 4,Phase 3 443-48-1 4173
31
Budesonide Approved Phase 4,Phase 3 51333-22-3 63006 5281004
32
Methotrexate Approved Phase 4,Phase 3 1959-05-2, 59-05-2 126941
33
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
34
Natalizumab Approved, Investigational Phase 4 189261-10-7
35
Vancomycin Approved Phase 4,Phase 2 1404-90-6 441141 14969
36 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1 943609-66-3
37
Copper Approved Phase 4 7440-50-8 27099
38
Zinc Approved Phase 4 7440-66-6 32051 23994
39
Thioguanine Approved Phase 4 154-42-7 2723601
40
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
41
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
42
Everolimus Approved Phase 4 159351-69-6 6442177
43
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
44
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
45
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
46
Losartan Approved Phase 4 114798-26-4 3961
47
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
48
Nicotine Approved Phase 4 54-11-5 942 89594
49
Sulfamethazine Approved, Vet_approved Phase 4 57-68-1 5327
50
Dalteparin Approved Phase 4 9005-49-6

Interventional clinical trials:

(show top 50) (show all 521)

id Name Status NCT ID Phase Drugs
1 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
4 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
5 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
6 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4 Vitamin D;Placebo
7 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
8 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
9 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
10 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
11 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
12 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
13 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
14 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
15 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
16 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
17 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
18 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
19 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
20 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
21 Low Volume Colon Preparation for IBD Completed NCT02248337 Phase 4 Colon preparation for colonoscopy
22 Gene Regulation by Thiazolidinediones Completed NCT00567593 Phase 4 Rosiglitazone
23 Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease Completed NCT01981889 Phase 4 Prednisone
24 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
25 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
26 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed NCT01034358 Phase 4
27 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease Completed NCT02162862 Phase 4 bupropion-SR
28 Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI) Completed NCT02437591 Phase 4 fidaxomicin
29 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
30 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
31 Immunogenicity of Hepatitis A Vaccine in Inflammatory Bowel Disease (IBD) Patients Completed NCT01341808 Phase 4
32 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
33 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
34 Satisfaction With Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl Sedation for Endoscopy Completed NCT01934088 Phase 4 Propofol;Midazolam;Fentanyl
35 Randomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy Completed NCT00746395 Phase 4 Lubiprostone;Placebo
36 Treatment of Ulcerative Colitis With Ciprofloxacin and E. Coli Nissle Completed NCT01772615 Phase 4 Ciprofloxacin
37 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
38 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
39 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
40 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
41 Dose Escalation and Remission (DEAR) Completed NCT00652145 Phase 4 mesalamine
42 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
43 Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole Completed NCT00640809 Phase 4 Celecoxib;Ibuprofen plus Omeprazole
44 Intragastric and Peritoneal Microdialysis in Infants With Necrotizing Enterocolitis (NEC) Completed NCT00332592 Phase 4
45 Asacol Dosing Study for Active Ulcerative Colitis Completed NCT00194818 Phase 4 Asacol (mesalamine)
46 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4 risedronate;placebo
47 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
48 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
49 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
50 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease

Search NIH Clinical Center for Inflammatory Bowel Disease 4

Genetic Tests for Inflammatory Bowel Disease 4

Anatomical Context for Inflammatory Bowel Disease 4

MalaCards organs/tissues related to Inflammatory Bowel Disease 4:

39
Colon, Bone, Testes, T Cells, Liver, Endothelial, Placenta

Publications for Inflammatory Bowel Disease 4

Articles related to Inflammatory Bowel Disease 4:

id Title Authors Year
1
Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed. ( 23197886 )
2012

Variations for Inflammatory Bowel Disease 4

Expression for Inflammatory Bowel Disease 4

Search GEO for disease gene expression data for Inflammatory Bowel Disease 4.

Pathways for Inflammatory Bowel Disease 4

Pathways related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 IL13 IL4 IL5 KIT NOD2
2
Show member pathways
12.54 EPX IL13 IL4 IL5 RNASE3
3
Show member pathways
12.33 IL13 IL4 IL5 NOD2
4
Show member pathways
12.07 IL13 IL4 IL5
5
Show member pathways
11.95 IL13 IL4 IL5
6
Show member pathways
11.91 IL13 IL4 IL5
7 11.75 IL4 IL5 KIT
8 11.64 IL4 IL5 KIT
9 11.55 IL13 IL4 IL5
10 11.41 IL13 IL4 IL5
11 11.22 IL13 IL4 IL5
12 11.16 IL13 IL4 IL5 KIT
13 11.09 IL4 IL5
14 11 IL13 IL4 IL5
15 10.95 IL13 IL4 IL5
16 10.91 IL13 IL4 IL5
17 10.75 IL13 IL4 IL5
18 9.98 IL13 IL4 IL5

GO Terms for Inflammatory Bowel Disease 4

Cellular components related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 IL13 IL4 KIT
2 extracellular space GO:0005615 9.1 EPX IL13 IL4 IL5 KIT RNASE3

Biological processes related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.81 IL4 IL5 KIT NOD2
2 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.58 IL4 IL5 KIT
3 positive regulation of Notch signaling pathway GO:0045747 9.55 KIT NOD2
4 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.54 KIT NOD2
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.52 IL13 IL4
6 positive regulation of interleukin-10 production GO:0032733 9.49 IL4 NOD2
7 innate immune response in mucosa GO:0002227 9.48 IL4 RNASE3
8 positive regulation of JAK-STAT cascade GO:0046427 9.46 IL5 KIT
9 microglial cell activation GO:0001774 9.43 IL13 IL4
10 positive regulation of mast cell degranulation GO:0043306 9.37 IL13 IL4
11 positive regulation of immunoglobulin production GO:0002639 9.32 IL13 IL4
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 IL4 KIT
13 regulation of proton transport GO:0010155 9.16 IL13 IL4
14 negative regulation of complement-dependent cytotoxicity GO:1903660 8.96 IL13 IL4
15 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.62 IL13 IL4

Sources for Inflammatory Bowel Disease 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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