MCID: INF087
MIFTS: 31

Inflammatory Bowel Disease 4

Categories: Genetic diseases, Rare diseases, Blood diseases, Bone diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Inflammatory Bowel Disease 4

MalaCards integrated aliases for Inflammatory Bowel Disease 4:

Name: Inflammatory Bowel Disease 4 53 12 13 14 69
Ibd4 53 12

Classifications:



External Ids:

OMIM 53 606675
Disease Ontology 12 DOID:0110903
UMLS 69 C1847691

Summaries for Inflammatory Bowel Disease 4

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 14q11-q12.

MalaCards based summary : Inflammatory Bowel Disease 4, also known as ibd4, is related to inflammatory bowel disease and eosinophilic granuloma. An important gene associated with Inflammatory Bowel Disease 4 is IBD4 (Inflammatory Bowel Disease 4), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Related phenotypes are digestive/alimentary and immune system

Description from OMIM: 606675

Related Diseases for Inflammatory Bowel Disease 4

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 28 Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 27.6 EPX IBD4 IL13 IL4 IL5 NOD2
2 eosinophilic granuloma 10.4 EPX RNASE3
3 conjunctival nevus 10.3 EPX RNASE3
4 blepharoconjunctivitis 10.3 IL4 RNASE3
5 inflammatory bowel disease 2 10.2 HOGA1 NOD2
6 collagenous colitis 10.2 EPX RNASE3
7 proctitis 10.2 EPX RNASE3
8 loeffler endocarditis 10.1 IL5 RNASE3
9 penicillin allergy 10.0 IL13 IL4
10 cow milk allergy 10.0 IL5 RNASE3
11 hypereosinophilic syndrome, idiopathic 10.0 IL5 KIT
12 vernal conjunctivitis 10.0 EPX IL4 RNASE3
13 beta-lactam allergy 10.0 IL13 IL4
14 chronic eosinophilic pneumonia 10.0 IL5 RNASE3
15 status asthmaticus 10.0 IL5 RNASE3
16 ocular cicatricial pemphigoid 10.0 IL4 RNASE3
17 sinusitis 10.0 IL5 RNASE3
18 cellulitis 9.9 IL5 RNASE3
19 inflammatory bowel disease 1 9.9 HOGA1 NOD2 NPL
20 acute graft versus host disease 9.9 IL4 NOD2
21 inflammatory bowel disease 3 9.9 HOGA1 NOD2 NPL
22 egg allergy 9.9 IL4 IL5
23 trichinosis 9.9 IL4 IL5
24 non-suppurative otitis media 9.9 IL4 IL5
25 wells syndrome 9.9 IL5 RNASE3
26 scleritis 9.9 IL4 IL5
27 cercarial dermatitis 9.8 IL4 IL5
28 cytokine deficiency 9.8 IL13 IL5
29 mesenteric lymphadenitis 9.8 IL5 NOD2
30 folliculitis 9.8 IL4 IL5
31 angioimmunoblastic lymphadenopathy with dysproteinemia 9.8 IL13 IL5
32 churg-strauss syndrome 9.8 IL5 RNASE3
33 respiratory syncytial virus infectious disease 9.8 IL13 IL5
34 eosinophilic gastroenteritis 9.8 EPX IL5 RNASE3
35 toxic oil syndrome 9.8 IL4 IL5
36 primary amebic meningoencephalitis 9.8 IL4 IL5
37 strongyloidiasis 9.8 IL13 IL5
38 nut allergy 9.8 IL13 IL5
39 night blindness, congenital stationary, type 1a 9.8 IL13 IL5
40 radiation cystitis 9.7 IL13 IL5
41 cough variant asthma 9.7 IL4 IL5 RNASE3
42 atopic keratoconjunctivitis 9.7 IL4 IL5 RNASE3
43 intrinsic asthma 9.7 IL4 IL5 RNASE3
44 gastrointestinal allergy 9.7 IL4 IL5 RNASE3
45 kimura disease 9.7 IL4 IL5 RNASE3
46 radiculopathy 9.7 IL13 IL5
47 milk allergy 9.7 IL4 IL5 RNASE3
48 gastroenteritis 9.7 IL4 IL5 RNASE3
49 allergic bronchopulmonary aspergillosis 9.6 EPX IL4 IL5
50 paragonimiasis 9.6 IL13 IL5 RNASE3

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 4:



Diseases related to Inflammatory Bowel Disease 4

Symptoms & Phenotypes for Inflammatory Bowel Disease 4

Clinical features from OMIM:

606675

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 4:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL13 IL4 IL5 KIT NOD2
2 immune system MP:0005387 9.17 EPX IL13 IL4 IL5 KIT NOD2

Drugs & Therapeutics for Inflammatory Bowel Disease 4

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 4

Genetic Tests for Inflammatory Bowel Disease 4

Anatomical Context for Inflammatory Bowel Disease 4

Publications for Inflammatory Bowel Disease 4

Articles related to Inflammatory Bowel Disease 4:

# Title Authors Year
1
Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed. ( 23197886 )
2012

Variations for Inflammatory Bowel Disease 4

Expression for Inflammatory Bowel Disease 4

Search GEO for disease gene expression data for Inflammatory Bowel Disease 4.

Pathways for Inflammatory Bowel Disease 4

Pathways related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 IL13 IL4 IL5 KIT NOD2
2 12.56 IL13 IL4 IL5 KIT
3
Show member pathways
12.54 EPX IL13 IL4 IL5 RNASE3
4
Show member pathways
12.33 IL13 IL4 IL5 NOD2
5
Show member pathways
12.1 IL13 IL4 IL5
6
Show member pathways
12.08 IL13 IL4 IL5
7
Show member pathways
11.91 IL13 IL4 IL5
8 11.75 IL4 IL5 KIT
9 11.64 IL4 IL5 KIT
10 11.55 IL13 IL4 IL5
11 11.41 IL13 IL4 IL5
12 11.29 IL13 IL4
13 11.21 IL13 IL4 IL5
14 11.16 IL13 IL4 IL5 KIT
15 11.1 IL4 IL5
16 11 IL13 IL4 IL5
17 10.97 IL13 IL4 IL5
18 10.91 IL13 IL4 IL5
19 10.76 IL13 IL4 IL5 KIT
20 10.75 IL13 IL4 IL5
21 9.88 IL13 IL4 IL5

GO Terms for Inflammatory Bowel Disease 4

Cellular components related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 EPX IL13 IL4 IL5 KIT RNASE3

Biological processes related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of Notch signaling pathway GO:0045747 9.37 KIT NOD2
2 negative regulation of endothelial cell apoptotic process GO:2000352 9.32 IL13 IL4
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.26 KIT NOD2
4 positive regulation of JAK-STAT cascade GO:0046427 9.16 IL5 KIT
5 negative regulation of complement-dependent cytotoxicity GO:1903660 8.96 IL13 IL4
6 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.62 IL13 IL4

Sources for Inflammatory Bowel Disease 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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