MCID: INF002
MIFTS: 30

Inflammatory Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Inflammatory Diarrhea

MalaCards integrated aliases for Inflammatory Diarrhea:

Name: Inflammatory Diarrhea 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050132

Summaries for Inflammatory Diarrhea

Disease Ontology : 12 A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

MalaCards based summary : Inflammatory Diarrhea is related to diarrhea and asphyxiating thoracic dystrophy. An important gene associated with Inflammatory Diarrhea is PITX1 (Paired Like Homeodomain 1), and among its related pathways/superpathways are Bacterial infections in CF airways and Salmonella infection (KEGG). The drugs Sucralfate and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include colon, prostate and breast, and related phenotype is digestive/alimentary.

Related Diseases for Inflammatory Diarrhea

Diseases in the Diarrhea family:

Diarrhea 7 Diarrhea 6
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Inflammatory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 diarrhea 10.0
2 asphyxiating thoracic dystrophy 9.8 CXCL8 TLR5
3 atrophy of prostate 9.7 CXCL8 SLC9A3
4 focal hand dystonia 9.7 FUT2 PITX1
5 kawasaki disease 9.5
6 salmonellosis 9.5
7 campylobacteriosis 9.5
8 cholera 9.5
9 adenoid squamous cell carcinoma 9.5 CXCL8 TLR5
10 colon adenocarcinoma 9.4 CXCL8 FUT2
11 subcutaneous mycosis 7.6 CXCL8 FUT2 PITX1 SLC9A3 TLR5 VIPR1

Graphical network of the top 20 diseases related to Inflammatory Diarrhea:



Diseases related to Inflammatory Diarrhea

Symptoms & Phenotypes for Inflammatory Diarrhea

MGI Mouse Phenotypes related to Inflammatory Diarrhea:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 FUT2 PITX1 SLC9A3 TLR5 VIPR1

Drugs & Therapeutics for Inflammatory Diarrhea

Drugs for Inflammatory Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 301)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sucralfate Approved Phase 4 54182-58-0
2
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
3
Zinc Approved Phase 4,Phase 3,Phase 1 7440-66-6 32051 23994
4
Infliximab Approved Phase 4,Phase 1,Phase 2 170277-31-3
5
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 63006 5281004
6
Colchicine Approved Phase 4 64-86-8 6167 2833
7
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
8
Ciprofloxacin Approved, Investigational Phase 4,Phase 2 85721-33-1 2764
9
Lenograstim Approved Phase 4,Phase 1 135968-09-1
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
11
Diphenhydramine Approved Phase 4,Phase 1 58-73-1, 147-24-0 3100
12
Dopamine Approved Phase 4,Phase 1 51-61-6, 62-31-7 681
13
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
14
Histamine Approved, Investigational Phase 4,Phase 2,Phase 1 75614-87-8, 51-45-6 774
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
16
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
17
Ondansetron Approved Phase 4 99614-02-5 4595
18
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
19
Promethazine Approved Phase 4,Phase 1 60-87-7 4927
20
Ranitidine Approved Phase 4,Phase 1 66357-59-3, 66357-35-5 3001055
21
Copper Approved Phase 4 7440-50-8 27099
22
Iron Approved Phase 4,Phase 2 7439-89-6 23925
23
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
24
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
25
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
27
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
28 Tocopherol Approved, Nutraceutical Phase 4
29
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
30
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
31
Curcumin Investigational Phase 4,Phase 2 458-37-7 969516
32
Docetaxel Approved May 1996, Investigational Phase 4,Phase 2 114977-28-5 148124 9877265
33 Dexchlorpheniramine Experimental Phase 4 25523-97-1
34 Anticholesteremic Agents Phase 4,Phase 1
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Antimetabolites Phase 4,Phase 2,Phase 1
37 Atorvastatin Calcium Phase 4 134523-03-8
38 Calcium, Dietary Phase 4,Phase 3,Phase 1,Phase 2
39 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 1
40 Hypolipidemic Agents Phase 4,Phase 2,Phase 1
41 Lipid Regulating Agents Phase 4,Phase 2,Phase 1
42 Antacids Phase 4,Phase 2,Phase 1
43 Anti-Ulcer Agents Phase 4,Phase 2,Phase 1
44 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Mesalamine Phase 4,Phase 3,Phase 2,Phase 1 89-57-6
48 Micronutrients Phase 4,Phase 3,Phase 1
49 Trace Elements Phase 4,Phase 3,Phase 1
50 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 145)

id Name Status NCT ID Phase Drugs
1 Anti-inflammatory Effect of Atorvastatin in Atherosclerotic Plaques Assessed by FDG-PET Imaging Unknown status NCT00920101 Phase 4 Atorvastatin
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial Unknown status NCT02016807 Phase 4
4 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
5 Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation Completed NCT00763399 Phase 4
6 Effect of Probiotics (Bio-Three) in Children's Enterocolitis Completed NCT00463190 Phase 4 Biothree
7 Prevention of Acute Radiation Enteritis With Glutamine Completed NCT00828399 Phase 4
8 Colchicine Or Naproxen Treatment for ACute gouT Completed NCT01994226 Phase 4 Low-dose colchicine;Naproxen 750 mg/250 mg
9 Mesalazine for the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D) Completed NCT01316718 Phase 4 Mesalazine;Placebo
10 Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial Completed NCT00779493 Phase 4
11 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed NCT00359216 Phase 4 Mometasone furoate nasal spray;Placebo
12 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
13 Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer Completed NCT02441894 Phase 4 CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
14 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Recruiting NCT02774057 Phase 4 Captafer®;Iron Sulfate
15 Clinical Study of Artz in the Treatment of Knee Osteoarthritis Recruiting NCT02826031 Phase 4 Sodium Hyaluronate Injection;DICL-SR
16 An Efficacy and Safety Study of Infliximab in Pediatric Participants With Inflammatory Bowel Disease Recruiting NCT02566889 Phase 4 Infliximab
17 Lactibiane Tolérance® in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Recruiting NCT02728063 Phase 4
18 Mortality Reduction After Oral Azithromycin: Morbidity Study Recruiting NCT02048007 Phase 4 Azithromycin;Placebo
19 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
20 Trial on the Effect of Budesonide/Formoterol and Inhaled Budesonide Alone on Exercise-Induced Asthma Terminated NCT01070888 Phase 4 Budesonide/Formoterol;Budesonide
21 Effects of Mesalamine and Amitriptyline on Irritable Bowel Syndrome Withdrawn NCT02190526 Phase 4 Mesalazine(asacol 800 mg);Amitriptyline;placebo like asacol;placebo like amitriptyline
22 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3 Budesonide
23 Saccharomyces Boulardii in Irritable Bowel Syndrome Completed NCT00589771 Phase 3 Saccharomyces boulardii;Placebo
24 Randomized, Controlled Trial - Lactoferrin Prevention of Diarrhea in Children Completed NCT00560222 Phase 3
25 Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis Completed NCT00151892 Phase 3 SPD476;Asacol
26 Zinc Supplementation in Shigella Patients Completed NCT00321126 Phase 3 Children in the zinc group received 20 mg of elemental zinc as acetate per day in a twice-daily dose for two weeks.
27 Sulfasalazine in Preventing Acute Diarrhea in Patients With Cancer Who Are Undergoing Pelvic Radiation Therapy Completed NCT01198145 Phase 3 sulfasalazine
28 Trial of Mesalamine for the Treatment of Active Microscopic Colitis Completed NCT00952952 Phase 2, Phase 3 Mesalamine
29 Emollients in the Management of Atopic Dermatitis Completed NCT01779258 Phase 3 glycerol, paraffin (liquid and white soft);Locatop@;Locapred@
30 A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease Completed NCT01243671 Phase 3
31 Myfortic vs. Cellcept in Kidney Transplant Recipients Completed NCT00533624 Phase 2, Phase 3 Mycophenolate Sodium Delayed Release Tablets;Mycophenolate Mofetil
32 Treatment of Gastro-Intestinal and/or Hepatic Graft Versus Host Disease With Budesonide in Patients Following Peripheral Blood Stem Cell Transplantation Completed NCT00128739 Phase 3 Budesonide
33 EUS-guided CGN for Inoperable Cancer Recruiting NCT02356640 Phase 2, Phase 3 Levobupivacaine
34 Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda Recruiting NCT02606526 Phase 3
35 Analgesia and Physiotherapy in Children With Cerebral Palsy (ANTALKINECP) Active, not recruiting NCT02839785 Phase 3 Ibuprofen;Placebo
36 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Not yet recruiting NCT02473341 Phase 3 Bovine Colostrum;Placebo
37 Probiotics for Prevention Neonatal Infection Terminated NCT01214473 Phase 2, Phase 3
38 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
39 Cannabis for Inflammatory Bowel Disease Unknown status NCT01040910 Phase 1, Phase 2 smoking of cannabis;smoking cigarettes with placebo
40 Wheat Flour Treatment With Microbial Transglutaminase and Lysine Ethyl Ester: New Frontiers in Celiac Disease Treatment. Unknown status NCT02472119 Phase 2
41 Melatonin & Ulcerative Colitis Unknown status NCT00790478 Phase 2
42 Effects of MSPrebiotic on Gut Health in the Elderly Unknown status NCT01977183 Phase 2
43 Bioactivity of Olive Oils Enriched With Their Own Phenolic Compounds (VOHF1) Unknown status NCT01347515 Phase 1, Phase 2
44 A Study to Investigate the Efficacy of LT-02 in Patients With Mesalazine Refractory Ulcerative Colitis Unknown status NCT01011322 Phase 2 LT-02;placebo
45 Efficacy of Mesalamine in Diarrhea-predominant Irritable Bowel Syndrome (dIBS) Completed NCT01327300 Phase 2 Mesalamine
46 Transplantation of Faeces in Ulcerative Colitis; Restoring Nature's Homeostasis Completed NCT01650038 Phase 2
47 Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
48 Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers Completed NCT00764361 Phase 2 doxycycline;placebo gel
49 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
50 Fecal Biotherapy for the Induction of Remission in Active Ulcerative Colitis Completed NCT01545908 Phase 2

Search NIH Clinical Center for Inflammatory Diarrhea

Genetic Tests for Inflammatory Diarrhea

Anatomical Context for Inflammatory Diarrhea

MalaCards organs/tissues related to Inflammatory Diarrhea:

39
Colon, Prostate, Breast, Bone, Kidney, T Cells, Bone Marrow

Publications for Inflammatory Diarrhea

Articles related to Inflammatory Diarrhea:

id Title Authors Year
1
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. ( 28581280 )
2017
2
Serum C-reactive protein (CRP) levels in young adults can be used to discriminate between inflammatory and non-inflammatory diarrhea. ( 22926497 )
2013
3
Human enteroids: preclinical models of non-inflammatory diarrhea. ( 24564938 )
2013
4
Inflammatory diarrhea due to enteroaggregative Escherichia coli: evidence from clinical and mice model studies. ( 24294997 )
2013
5
Diarrhea. Enterotoxigenic Bacteroides fragilis: newly recognized cause of inflammatory diarrhea. ( 19678432 )
2009
6
Association of enterotoxigenic Bacteroides fragilis infection with inflammatory diarrhea. ( 18680416 )
2008
7
Dangers of empiric oral ciprofloxacin in the treatment of acute inflammatory diarrhea in children. ( 11734755 )
2001
8
Mechanisms of inflammatory diarrhea. ( 1634090 )
1992
9
Clinical and immunologic significance of cholera-like toxin and cytotoxin production by Campylobacter species in patients with acute inflammatory diarrhea in the USA. ( 2760498 )
1989
10
Kawasaki disease presenting in an adult as inflammatory diarrhea. ( 3509115 )
1987

Variations for Inflammatory Diarrhea

Expression for Inflammatory Diarrhea

Search GEO for disease gene expression data for Inflammatory Diarrhea.

Pathways for Inflammatory Diarrhea

GO Terms for Inflammatory Diarrhea

Biological processes related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 8.62 CXCL8 TLR5

Sources for Inflammatory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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