MCID: INF058
MIFTS: 37

Inflammatory Myofibroblastic Tumor malady

Cancer diseases category

Summaries for Inflammatory Myofibroblastic Tumor

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Inflammatory myofibroblastic tumor is made up of specific cells called myofibroblastic spindle cells. this tumor can occur in many different parts of the body, but it occurs most frequently in the lungs, soft tisues, or internal organs. inflammatory myofibroblastic tumor usually develops in children or young adults, although it can affect people of any age. this type of tumor tends to recur in the same location, but it rarely spreads (metastasizes) to other parts of the body. approximately 50% of inflammatory myofibroblastic tumors have rearrangements of the alk gene on chromosome 2. treatment typically involves surgery to remove the tumor. last updated: 11/2/2010

MalaCards: Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to fibrosarcoma and anaplastic large cell lymphoma. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Cardiac muscle contraction and Cytoskeleton remodeling Neurofilaments. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 Inflammatory myofibroblastic tumour is a lesional pattern of inflammatory pseudotumour, as plasma cell... more...

Aliases & Classifications for Inflammatory Myofibroblastic Tumor

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 44Novoseek, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

inflammatory myofibroblastic tumor 42 48 60
inflammatory fibrosarcoma 42
inflammatory pseudotumor 42
pseudotumor inflammatory 44


External Ids:

SNOMED-CT via Orphanet57 116064009
UMLS via Orphanet61 C0334121

Related Diseases for Inflammatory Myofibroblastic Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1fibrosarcoma30.6VIM, DES, ACTC1, ALK
2anaplastic large cell lymphoma30.6ACVRL1, ALK, TPM4, TPM3
3peritonitis30.5SLPI
4sarcoma30.5VIM, S100A1, CR2, F13A1, DES, CDK4
5spindle cell carcinoma30.4VIM, DES, ACTC1
6leukemia30.2CR2, CDK4, HMGA2, SLPI, ALK
7hepatitis30.1CLTC
8breast cancer30.1HMGA2, CDK4
9meningioma30.1S100A1, VIM
10liposarcoma30.1HMGA2, CDK4, DES, VIM
11fibrous histiocytoma30.1ACTC1, DES, F13A1, VIM
12smooth muscle tumor30.1VIM, S100A1, CR2, DES, HMGA2, ACTC1
13rhabdomyosarcoma30.1VIM, S100A1, DES, CDK4, ACTC1, ACVRL1
14hemangioma29.9ACTC1, F13A1
15angiomyolipoma29.9VIM, S100A1, DES, ACTC1
16adenoma29.9S100A1, CDK4, HMGA2, ACTC1
17pancreatitis10.6
18intussusception10.4
19bladder lymphoma10.4
20esophagitis10.4
21laryngitis10.4
22mediastinitis10.4
23renal cell carcinoma10.4
24cholangitis10.3
25sclerosing cholangitis10.3
26cholangiocarcinoma10.3
27systemic lupus erythematosus10.3
28pemphigus10.3
29hepatocellular carcinoma10.3
30lupus erythematosus10.3
31meningitis10.3
32prostatitis10.3
33tuberculosis10.3
34follicular dendritic cell sarcoma10.1
35dendritic cell sarcoma10.1
36intrahepatic cholangiocarcinoma10.1
37myositis10.1
38spondylolisthesis10.1
39acute pancreatitis10.1
40maxillary neoplasm10.1
41fibrosarcoma of bone10.1
42cerebritis10.1
43eosinophilic esophagitis10.1
44middle cranial fossa meningioma10.1
45thrombocytosis10.1
46liver inflammatory pseudotumor10.1
47orbital plasma cell granuloma10.1
48inflammatory liposarcoma10.1
49lung lymphoma10.1
50intraocular lymphoma10.1

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:



Diseases related to inflammatory myofibroblastic tumor

Clinical Features for Inflammatory Myofibroblastic Tumor

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Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

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32MalaCards
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MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

32
Lung

Animal Models for Inflammatory Myofibroblastic Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Inflammatory Myofibroblastic Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7ACVRL1, CR2, F13A1, DES, CDK4, RANBP2

Publications for Inflammatory Myofibroblastic Tumor

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Genetic Variations for Inflammatory Myofibroblastic Tumor

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Expression for genes affiliated with Inflammatory Myofibroblastic Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inflammatory Myofibroblastic Tumor

Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

Pathways for genes affiliated with Inflammatory Myofibroblastic Tumor

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology
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Compounds for genes affiliated with Inflammatory Myofibroblastic Tumor

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1procollagen4410.5F13A1
2estrogen4410.3F13A1, CR2
3orcein4410.1ACTC1, DES, VIM
42-methoxyethanol4410.0VIM, S100A1, ACTC1
5actomyosin449.9VIM, S100A1, ACTC1
6toluidine449.9DES, S100A1, VIM
7progestin449.8VIM, DES, CDK4
8s 100449.8ACTC1, DES, F13A1, VIM
9reticulin449.8VIM, F13A1, DES, ACTC1
10silver449.8DES, F13A1, S100A1
11mucicarmine449.8VIM, S100A1, DES, ACTC1
12biotin44 11 2411.7VIM, S100A1, DES, ACTC1
13acetic acid44 28 11 2412.6VIM, F13A1, SLPI
14vitamin k2449.6CDK4, SLPI
15azathioprine44 49 2 1112.5SLPI, DES, VIM
16nacl449.5CARS, S100A1, DES, SLPI
17doxorubicin44 49 1111.5ALK, HMGA2, CDK4, DES, VIM
18tgf beta1449.5VIM, CDK4, SLPI, ACVRL1
19b 723449.4VIM, S100A1, F13A1, DES, ACTC1
20tartrate449.4VIM, SLPI
21vitamin d449.4SLPI, CDK4, CARS, VIM
22glycogen44 2410.4ACTC1, CDK4, DES, S100A1, VIM
23progesterone44 59 28 11 2413.1VIM, S100A1, F13A1, DES, CDK4, ACTC1
24testosterone44 59 11 2412.1VIM, DES, CDK4, SLPI, ACTC1
25oligonucleotide448.9ACVRL1, SLPI, CDK4, F13A1, VIM
26cysteine448.8VIM, CARS, S100A1, DES, CDK4, SLPI
27vegf448.8VIM, F13A1, DES, CDK4, SLPI, ACTC1
28hematoxylin448.8ACTC1, VIM, S100A1, CR2, F13A1, DES
29retinoic acid44 249.7VIM, S100A1, DES, CDK4, HMGA2, SLPI
30iron44 249.7VIM, S100A1, F13A1, DES, CDK4, SLPI
31tyrosine448.6S100A1, CR2, DES, CDK4, SLPI, ACTC1
32serine448.6VIM, CR2, DES, CDK4, SLPI, ACVRL1
33paraffin448.5VIM, S100A1, CR2, F13A1, DES, CDK4
34calcium44 49 11 2410.6CARS, S100A1, CR2, F13A1, DES, CDK4

GO Terms for genes affiliated with Inflammatory Myofibroblastic Tumor

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16Gene Ontology
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Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle thin filament tropomyosinGO:00586210.0TPM3, TPM4
2intermediate filamentGO:0058829.7SYNM, DES, VIM
3extracellular vesicular exosomeGO:0700629.5VIM, CLTC, ACTC1
4cytosolGO:0058298.1TPM3, VIM, CARS, DES, CDK4, CLTC

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.8TPM3, TPM4, VIM
2muscle contractionGO:0069369.6DES, TPM4, TPM3
3muscle filament slidingGO:0300499.3TPM3, TPM4, ACTC1, DES, VIM

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.7SYNM, DES, VIM
2protein bindingGO:0055156.3ALK, VIM, CARS, S100A1, DES, SYNM

Products for genes affiliated with Inflammatory Myofibroblastic Tumor

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Sources for Inflammatory Myofibroblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet