MCID: INF058
MIFTS: 48

Inflammatory Myofibroblastic Tumor malady

Rare diseases, Cancer diseases categories
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Summaries for Inflammatory Myofibroblastic Tumor

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Inflammatory myofibroblastic tumor is made up of specific cells called myofibroblastic spindle cells. this tumor can occur in many different parts of the body, but it occurs most frequently in the lungs, soft tisues, or internal organs. inflammatory myofibroblastic tumor usually develops in children or young adults, although it can affect people of any age. this type of tumor tends to recur in the same location, but it rarely spreads (metastasizes) to other parts of the body. approximately 50% of inflammatory myofibroblastic tumors have rearrangements of the alk gene on chromosome 2. treatment typically involves surgery to remove the tumor. last updated: 11/2/2010

MalaCards: Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to fibrosarcoma and anaplastic large cell lymphoma. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Adrenergic signaling in cardiomyocytes and Cardiac muscle contraction. The compounds orcein and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone.

Wikipedia:65 Inflammatory myofibroblastic tumour is a lesional pattern of inflammatory pseudotumour, as plasma cell... more...

Aliases & Classifications for Inflammatory Myofibroblastic Tumor

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43NIH Rare Diseases, 49Orphanet, 62UMLS, 45Novoseek, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 49 
Rare tumors


Aliases & Descriptions:

inflammatory myofibroblastic tumor 43 49 62
inflammatory fibrosarcoma 43
inflammatory pseudotumor 43
pseudotumor inflammatory 45


External Ids:

SNOMED-CT via Orphanet59 116064009
UMLS via Orphanet63 C0334121

Related Diseases for Inflammatory Myofibroblastic Tumor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:



Diseases related to inflammatory myofibroblastic tumor

Symptoms for Inflammatory Myofibroblastic Tumor

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Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Inflammatory Myofibroblastic Tumor

Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

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33MalaCards
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MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

33
Lung, Liver, Bone, Trachea, Heart, Spleen, Breast, Pancreas, Kidney, Colon, Lymph node, Uterus, Skin, Testes, Tongue, Prostate, Bone marrow, Small intestine, Thyroid, Testis, B cells, Smooth muscle, Brain, Appendix

Animal Models for Inflammatory Myofibroblastic Tumor or affiliated genes

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Publications for Inflammatory Myofibroblastic Tumor

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52PubMed
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Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50)    (show all 419)
idTitleAuthorsYear
1
Malignant inflammatory myofibroblastic tumor of the prostate. (23401456)
2013
2
Primary inflammatory myofibroblastic tumor of the stomach in an adult woman: a case report and review of the literature. (23374227)
2013
3
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report. (24273608)
2013
4
Successful Sleeve Lobectomy of Inflammatory Myofibroblastic Tumor in a 4-year-old Child. (23445794)
2013
5
Inflammatory myofibroblastic tumor of the temporal bone presenting with pulsatile tinnitus: a case report. (23787119)
2013
6
A case of recurrent pulmonary inflammatory myofibroblastic tumor with aggressive metastasis after complete resection. (24265646)
2013
7
Inflammatory myofibroblastic tumor of trachea. (23328150)
2013
8
Fusion of dynactin 1 to anaplastic lymphoma kinase in inflammatory myofibroblastic tumor. (22658521)
2012
9
Inflammatory myofibroblastic tumor of the stomach in an adult female--report of a rare case and review of the literature. (22965515)
2012
10
Regression of an inflammatory myofibroblastic tumor of the porta-hepatis with steroid drugs. (22693097)
2012
11
Rare gastric inflammatory myofibroblastic tumor in an adult woman: a case report with review of the literature. (22570660)
2012
12
Carboplatin plus paclitaxel in the successful treatment of advanced inflammatory myofibroblastic tumor. (22975556)
2012
13
Invasive inflammatory myofibroblastic tumor of the spleen treated with partial splenectomy in a child. (22469943)
2012
14
Inflammatory myofibroblastic tumor of the skin grossly mimicking squamous cell carcinoma: a case report. (21545500)
2012
15
Bilateral simultaneous inflammatory myofibroblastic tumor of the lung with distant metastatic spread. (21606052)
2011
16
Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification. (21430068)
2011
17
Rubbery palatal mass. Inflammatory myofibroblastic tumor. (21903528)
2011
18
Multiorgan involvement in HHV-8-positive multifocal inflammatory myofibroblastic tumor. (21796573)
2011
19
Abdominal inflammatory myofibroblastic tumor: report on four cases and review of literature. (23056847)
2011
20
Pulmonary inflammatory myofibroblastic tumor invading the gastroesophageal junction. (20417808)
2010
21
Inflammatory myofibroblastic tumor of the esophagus. (20103355)
2010
22
Inflammatory myofibroblastic tumor presenting as an abdominal wall mass in an adult patient. (20622374)
2010
23
Inflammatory myofibroblastic tumor of the infratemporal fossa. (20551572)
2010
24
Clinicopathologic study of sinonasal inflammatory myofibroblastic tumor]. (20450762)
2010
25
Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature. (18436455)
2009
26
Inflammatory myofibroblastic tumor in the larynx. (18852998)
2008
27
An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features. (18701132)
2008
28
Case report: inflammatory myofibroblastic tumor of the duodenum. (19142589)
2008
29
Inflammatory myofibroblastic tumor of the lung: unusual presentation. (18297338)
2008
30
Renal inflammatory myofibroblastic tumor: a rare tumor indistinguishable from renal cell carcinomaa89report of two cases. (17963086)
2007
31
Inflammatory myofibroblastic tumor of the midesophagus. (18363157)
2007
32
Inflammatory myofibroblastic tumor of the bladder in children: what can be expected? (17443333)
2007
33
Primary renal inflammatory myofibroblastic tumor. (16401931)
2006
34
Inflammatory myofibroblastic tumor of the renal pelvis]. (16479987)
2006
35
A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining]. (16758729)
2006
36
Inflammatory myofibroblastic tumor of the liver. (17090200)
2006
37
Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature. (17008862)
2006
38
Acute abdomen caused by a perforated inflammatory myofibroblastic tumor of the jejunum. (16774173)
2006
39
Inflammatory myofibroblastic tumor (inflammatory pseudotumor) of the breast. (15676017)
2005
40
Inflammatory myofibroblastic tumor associated with renal cell carcinoma. (16230166)
2005
41
Inflammatory myofibroblastic tumor presenting as a pancreatic mass: a case report and review of the literature. (15365204)
2004
42
Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor. (13679433)
2003
43
Inflammatory myofibroblastic tumor of the left ventricle in an older adult. (12822653)
2003
44
Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. (12218210)
2002
45
Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor. (11485898)
2001
46
Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. (11684952)
2001
47
ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family? (11284039)
2001
48
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. (10383129)
1999
49
Renal failure resulting from infiltration by inflammatory myofibroblastic tumor responsive to corticosteroid therapy. (10074585)
1998
50
Radiological case of the month. Inflammatory myofibroblastic tumor. (7581760)
1995

Variations for Inflammatory Myofibroblastic Tumor

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Expression for genes affiliated with Inflammatory Myofibroblastic Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inflammatory Myofibroblastic Tumor

Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

Pathways for genes affiliated with Inflammatory Myofibroblastic Tumor

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50PathCards, 30KEGG, 5Cell Signaling Technology, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TPM3, TPM4, ACTC1
29.3TPM4, TPM3, ACTC1
39.2CLTC, ACTC1, DES
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
8.8DES, TPM4, TPM3, ACTC1
5
Show member pathways
8.8DES, TPM4, TPM3, ACTC1

Compounds for genes affiliated with Inflammatory Myofibroblastic Tumor

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45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank
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Compounds related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1orcein459.7ACTC1, DES
2[alcl]459.7ALK, ACVRL1
3s 100459.6ACTC1, DES
4reticulin459.6DES, ACTC1
5mucicarmine459.6ACTC1, DES
6b 723459.4ACTC1, DES
7hematoxylin459.1DES, ACTC1, CR2
8streptavidin459.0CR2, DES
9paraffin458.8CR2, ALK, ACTC1, DES
10tyrosine458.2ACTC1, TPM3, DES, CR2, ALK
11calcium45 51 24 1110.8CR2, DES, TPM4, TPM3, CLTC, ACTC1

GO Terms for genes affiliated with Inflammatory Myofibroblastic Tumor

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16Gene Ontology
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Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle thin filament tropomyosinGO:00586210.0TPM3, TPM4
2podosomeGO:0021029.8TPM3, TPM4
3stress fiberGO:0017259.8TPM3, TPM4
4filamentous actinGO:0319419.7TPM4, TPM3
5cortical cytoskeletonGO:0308639.5TPM3, TPM4
6extracellular vesicular exosomeGO:0700628.2TPM4, TPM3, CLTC, ACTC1, ALK, CR2
7cytosolGO:0058298.0DES, TPM4, TPM3, CLTC, ACTC1, CARS

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:0069369.3TPM3, TPM4, DES
2muscle filament slidingGO:0300498.5ACTC1, TPM3, TPM4, DES

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:0083079.4SYNM, TPM4

Products for genes affiliated with Inflammatory Myofibroblastic Tumor

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Sources for Inflammatory Myofibroblastic Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet