MCID: INF058
MIFTS: 46

Inflammatory Myofibroblastic Tumor malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Inflammatory Myofibroblastic Tumor

About this section
Sources:
11Disease Ontology, 13DISEASES, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Inflammatory Myofibroblastic Tumor:

Name: Inflammatory Myofibroblastic Tumor 11 48 54 13 68
Inflammatory Fibrosarcoma 48
 
Inflammatory Pseudotumor 48
Pseudotumor Inflammatory 50

Classifications:



External Ids:

Disease Ontology11 DOID:0050905
Orphanet54 ORPHA178342
UMLS via Orphanet69 C0334121

Summaries for Inflammatory Myofibroblastic Tumor

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NIH Rare Diseases:48 An inflammatory myofibroblastic tumor (IMT) is an uncommon, presumably benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age. An IMT can occur in almost any part of the body but is most commonly found in the lung, orbit (eye socket), peritoneum (lining of the abdominal cavity and internal organs), and mesentery. Signs and symptoms vary depending on the site of the tumor. Some people with an IMT are asymptomatic, while others may have nonspecific respiratory symptoms, fever, or pain. IMTs may recur, and occasionally become locally invasive and/or spread (metastasize) to other parts of the body. The underlying cause of IMTs is poorly understood. Some cases have been linked to translocations involving the ALK gene. Treatment involves surgical removal when possible, although there are reports of treatment with oral steroids and radiation therapy. Last updated: 2/8/2016

MalaCards based summary: Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to gastrointestinal stromal tumor and liver inflammatory pseudotumor, and has symptoms including pain and vestibulitis. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase), and among its related pathways are Sumoylation by RanBP2 regulates transcriptional repression and Cardiac muscle contraction. Affiliated tissues include lung, liver and bone, and related mouse phenotypes are cardiovascular system and muscle.

Disease Ontology:11 A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells.

Related Diseases for Inflammatory Myofibroblastic Tumor

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Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1gastrointestinal stromal tumor29.3ACTC1, DES, KIT, S100B, TP53, VIM
2liver inflammatory pseudotumor11.1
3lymphangiomatosis10.8ACTC1, VIM
4myxoid liposarcoma of the ovary10.8ACTC1, VIM
5harding ataxia10.7DES, VIM
6infantile glycine encephalopathy10.7ACTC1, S100B
7hypotonia10.7S100B, VIM
8anaplastic oligoastrocytoma10.7S100B, VIM
9iridogoniodysgenesis and skeletal anomalies10.7ACTC1, VIM
10exstrophy-epispadias complex10.7S100B, VIM
11lymphocytic vasculitis10.7DES, VIM
12intravascular fasciitis10.7ACTC1, DES
13diffuse pulmonary fibrosis10.7ACTC1, S100B
14mollaret meningitis10.6ACTC1, DES, VIM
15relapsing epidemic typhus10.6KIT, S100B
16malignant glandular tumor of peripheral nerve sheath10.6ACTC1, DES, VIM
17absence of fingerprints congenital milia10.6DES, S100B, VIM
18xq12-q13.3 duplication syndrome10.6ACTC1, DES, KIT
19pineal parenchymal tumor of intermediate differenciation10.6ACTC1, S100B, VIM
20t-cell childhood acute lymphocytic leukemia10.6ACTC1, DES, VIM
21bartholin's gland benign neoplasm10.6DES, S100B, VIM
22malignant adenofibroma10.6DES, S100B, VIM
23glucocorticoid-induced osteoporosis10.6ALK, TP53
24staphyloenterotoxemia10.6ACTC1, DES, VIM
25penile urethral cancer10.6CR1, CR2
26pura syndrome10.6ACTC1, DES, KIT
27focal chorioretinitis10.6DES, KIT, VIM
28fraxf syndrome10.6S100B, VIM
29intermediate cell type ciliary body melanoma10.6CCND1, S100B
30renal tubular acidosis, distal, autosomal recessive10.6DES, S100B, VIM
31breast rhabdomyosarcoma10.6DES, KIT
32epithelioid cell melanoma10.6KIT, S100B, VIM
33pleuropulmonary blastoma type 210.5ACTC1, DES, MDM2
34acute panmyelosis with myelofibrosis10.5KIT, NPM1
35lymphangiosarcoma10.5ACTC1, DES, S100B, VIM
36chondroblastoma10.5ACTC1, DES, S100B, VIM
37pulmonary venoocclusive disease10.5ACTC1, DES, S100B, VIM
38gallbladder leiomyosarcoma10.5ACTC1, DES, S100B, VIM
39anus leiomyosarcoma10.5ACTC1, DES, S100B, VIM
40megarbane jalkh syndrome10.5ACTC1, DES, S100B, VIM
41pancreatic intraductal papillary-mucinous adenoma10.5CR1, CR2
42small intestinal sarcoma10.5ACTC1, ALK, TP53
43sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes10.5CR1, CR2, S100B
44bickerstaff brainstem encephalitis10.5DES, S100B
45mushroom workers' lung10.5ACTC1, S100B, TP53
46chromosome 7p duplication10.4MDM2, TP53
47parachordoma10.4ACTC1, DES, KIT, VIM
48paranasal sinus cancer, adult10.4ACTC1, TP53, VIM
49frontal sinus squamous cell carcinoma10.4ACTC1, DES, KIT, VIM
50gastric cardia carcinoma10.4CR1, CR2, KIT

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:



Diseases related to inflammatory myofibroblastic tumor

Symptoms & Phenotypes for Inflammatory Myofibroblastic Tumor

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UMLS symptoms related to Inflammatory Myofibroblastic Tumor:


pain, vestibulitis

MGI Mouse Phenotypes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3ACTC1, ACVRL1, CCND1, DES, KIT, MDM2
2MP:00053698.1ACTC1, ACVRL1, DES, KIT, MDM2, TP53
3MP:00053767.7ACTC1, ACVRL1, ALK, CCND1, CR2, DES

Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

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Drugs for Inflammatory Myofibroblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Cyclophosphamideapproved, investigationalPhase 2, Phase 3282950-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
2
IfosfamideapprovedPhase 2, Phase 33913778-73-23690
Synonyms:
(+-)-Ifosfamid
(+-)-Ifosphamide
(+-)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
(D,L)-Ifosfamide
(R,S)-Ifosphamide
(R,S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd
2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis( 2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (8CI)
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
3,} 2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2- oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
36341-88-5
3778-73-2
84711-20-6
A 4942
AB00513932
AC-2113
AC1L1GHW
ASTA Z 4942
Ambap3778-73-2
Asta Z 4942
BPBio1_000865
BRN 0611835
BSPBio_000785
C07047
CAS-3778-73-2
CCRIS 352
CHEBI:5864
CHEMBL1024
CID3690
Cyfos
D00343
D007069
DB01181
EINECS 223-237-3
HMS1570H07
HMS2090M12
HMS2093N07
HSDB 7023
Holoxan
Holoxan 1000
I-Phosphamide
I06-0494
IFEX (TN)
Ifex
Ifosfamid
Ifosfamida
Ifosfamida [INN-Spanish]
Ifosfamide (JAN/USP/INN)
 
Ifosfamide Sterile
Ifosfamide [USAN:INN:BAN:JAN]
Ifosfamidum
Ifosfamidum [INN-Latin]
Ifosphamide
Ifsofamide
Iphosphamid
Iphosphamid(e)
Iphosphamide
Iso Endoxan
Iso-Endoxan
Isoendoxan
Isofosfamide
Isophosphamide
Isosfamide
LS-102
LS-99799
MJF 9325
MJF-9325
MLS002154021
Mitoxana
Mitoxana, Ifex, Ifosfamide
MolPort-003-666-704
N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylen ephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide
N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine
NCGC00016639-01
NCGC00179435-01
NCI-C01638
NCI60_000233
NPFAPI-04
NSC 109,724
NSC 109724
NSC-109,724
NSC-109724
NSC109,724
NSC109724
Naxamide
Prestwick0_000833
Prestwick1_000833
Prestwick2_000833
Prestwick3_000833
S1302_Selleck
SMR001233348
SPBio_002706
STL058690
UNII-UM20QQM95Y
WLN: T6NPOTJ AM2G BO B2G
Z 4942
Z-4942
Z4942
ifosfamide
isosfamide
{3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,
3
MechlorethamineapprovedPhase 2, Phase 337751-75-24033
Synonyms:
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
2,2'-dichloro-N-methyldiethylamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
302-70-5 (N-oxide, hydrochloride)
51-75-2
55-86-7 (HYDROCHLORIDE)
AC1L1H9H
Antimit
BRN 0605323
BSPBio_001947
Bis(2-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
C07115
C5H11Cl2N
CCRIS 447
CHEBI:28925
CHEMBL427
CID4033
Carolysine
Caryolysin
Caryolysine
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinum [INN-Latin]
Cloramin
Clormetina
Clormetina [INN-Spanish]
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
DivK1c_000759
EINECS 200-120-5
ENT-25294
Embechine
Embichin
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
 
KBioGR_001448
KBioSS_001369
LS-7559
MBA
Me chloroethamine
Mebichloramine
Mechlorethamine
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
MolPort-001-785-592
Mustargen
Mustine
Mustine note
Mutagen
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-lost
N-Methyl-lost [German]
N-methyl-bis(2-chloroethyl)amine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCI60_041682
NINDS_000759
NSC762
Nitol (*Hydrochloride*)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
SPBio_000496
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Spectrum_000889
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
T 1024
T-1024
TL 146
UNII-50D9XSG0VR
beta,Beta'-dichlorodiethyl-N-methylamine
beta,beta'-Dichlorodiethyl-N-methylamine
mechlorethamine
thyldiethylamine
β,β'-dichlorodiethyl-N-methylamine
4
Doxorubicinapproved, investigationalPhase 2, Phase 3171423214-92-831703
Synonyms:
(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
111266-55-8
14-Hydroxydaunomycin
14-Hydroxydaunorubicine
14-hydroxydaunomycin
14-hydroxydaunorubicine
23214-92-8
23257-17-2
24385-08-8
25311-50-6
25316-40-9
25316-40-9 (hydrochloride)
29042-30-6
AC1L1M5T
AC1Q29OJ
ADM
ADR
Adriablastin
Adriacin (hydrochloride salt)
Adriamycin
Adriamycin PFS
Adriamycin PFS (hydrochloride salt)
Adriamycin RDF
Adriamycin RDF (hydrochloride salt)
Adriamycin Semiquinone
Adriamycin semiquinone
Adriblas tina
Adriblastin
Adriblastina
Adriblastina (TN)
Adriblastina (hydrochloride salt)
Aerosolized Doxorubicin
BPBio1_000502
BRD-K92093830-003-04-3
BSPBio_000456
BSPBio_001031
C01661
C27H29NO11
CCRIS 739
CHEBI:28748
CHEMBL179
CID31703
Caelyx
Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74
Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120
D03899
DB00997
DM2
DOX-SL
Doxil
Doxo
Doxorubicin
Doxorubicin (USAN/INN)
Doxorubicin HCl
 
Doxorubicin Hydrochloride
Doxorubicin [USAN:INN:BAN]
Doxorubicin citrate
Doxorubicin hydrochloride (hydrochloride salt)
Doxorubicin-P4/D10
Doxorubicin-P4/D10 conjugate
Doxorubicin-hLL1
Doxorubicin-hLL1 conjugate
Doxorubicina
Doxorubicina [INN-Spanish]
Doxorubicine
Doxorubicine [INN-French]
Doxorubicinum
Doxorubicinum [INN-Latin]
EINECS 245-495-6
FI 106
Farmablastina (hydrochloride salt)
HMS2089H06
HSDB 3070
Hydroxydaunomycin hydrochlor ide (hydrochloride salt)
Hydroxydaunomycin hydrochloride (hydrochloride salt)
Hydroxydaunorubicin
Hydroxydaunorubicin hydrochloride (hydrochloride salt)
JT9100000
LMPK13050001
LS-1029
LS-165655
MLS000759533
Myocet
NCI-C01514
NChemBio.2007.10-comp13
NDC 38242-874
NIOSH/JT9100000
NSC 123127
Prestwick0_000438
Prestwick1_000438
Prestwick2_000438
Prestwick3_000438
Probes1_000151
Probes2_000129
RDF Rubex
Resmycin
Rubex
Rubex (hydrochloride salt)
SMP1_000106
SPBio_002395
TLC D-99
ThermoDox
Triferric doxorubicin
UNII-80168379AG
adiblastine (hydrochloride salt)
adr iablatina (hydrochloride salt)
adriablastine (hydrochloride salt)
adriablatina (hydrochloride salt)
adriblatina (hydrochloride salt)
doxorubicin
nchembio809-comp5
5
DoxilApproved June 1999Phase 2, Phase 3171431703
Synonyms:
Dox-SL
Doxil
 
Evacet
LipoDox
Pegylated Liposomal Doxorubicin Hydrochloride
liposomal doxorubicin
6Alkylating AgentsPhase 2, Phase 34694
7Topoisomerase InhibitorsPhase 2, Phase 34945
8Isophosphamide mustardPhase 2, Phase 3391
9Anti-Bacterial AgentsPhase 2, Phase 310884
10Antibiotics, AntitubercularPhase 2, Phase 36972
11Antineoplastic Agents, AlkylatingPhase 2, Phase 34474
12
CrizotinibapprovedPhase 297877399-52-511626560, 10366136, 10366137, 10366138, 10366139, 10366140, 10366141
Synonyms:
(R)-Crizotinib
C-Met/HGFR Tyrosine Kinase Inhibitor PF-02341066
C-Met/Hepatocyte Growth Factor Receptor Tyrosine Kinase Inhibitor PF-02341066
Crizotinib
Crizotinibum
 
MET Tyrosine Kinase Inhibitor PF-02341066
PF 2341066
PF-02341066
PF-2341066
Xalkori
crizotinib
13MitogensPhase 1, Phase 21526
14Protein Kinase InhibitorsPhase 2, Phase 13612
15
CeritinibapprovedPhase 1361032900-25-6
Synonyms:
2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2- isopropylsulfonyl)phenyl) pyrimidine-2,4-diamine
LDK378
 
N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamide
Zykadia
céritinib
16ImmunoglobulinsEarly Phase 16045
17Immunoglobulin GEarly Phase 1265
18AntibodiesEarly Phase 16045

Interventional clinical trials:

idNameStatusNCT IDPhase
1Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by SurgeryRecruitingNCT02180867Phase 2, Phase 3
2Low-dose Protocol for Computed Tomography-guided Lung BiopsyEnrolling by invitationNCT02971176Phase 3
3A Phase 1/2 Study of the Oral ALK/EGFR Inhibitor AP26113Unknown statusNCT01449461Phase 1, Phase 2
4Phase 2 Study Assessing Efficacy and Safety of Crizotinib in Patients Harboring an Alteration on ALK, MET or ROS1RecruitingNCT02034981Phase 2
5CREATE: Cross-tumoral Phase 2 With CrizotinibRecruitingNCT01524926Phase 2
6Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung CancerRecruitingNCT01625234Phase 1, Phase 2
7Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)RecruitingNCT01742286Phase 1
8Cohort Study of IgG4RDUnknown statusNCT01670695Early Phase 1

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Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

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MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

36
Lung, Liver, Bone, Trachea, Heart, Spleen, Kidney

Publications for Inflammatory Myofibroblastic Tumor

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Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Inflammatory myofibroblastic tumor: An unusual hepatic tumor mimicking liver abscess. (28089176)
2017
2
Robot-assisted Partial Cystectomy for Treatment of Inflammatory Myofibroblastic Tumor of the Bladder. (28083481)
2017
3
Gastric inflammatory myofibroblastic tumor presenting as fever of unknown origin in a 9-year-old girl. (27748672)
2017
4
Inflammatory myofibroblastic tumor involving liver, gallbladder, pylorus & duodenum: A rare case presentation. (28092784)
2017
5
Successful Preservation of the Bladder in a Case of Inflammatory Myofibroblastic Tumor with the Diagnostic Efficacy of ALK/p80 Immunohistochemistry and FISH Analysis: Case Report and Review of the Literature. (28083479)
2017
6
A case report of inflammatory myofibroblastic tumor of urinary bladder. (27453664)
2016
7
Inflammatory myofibroblastic tumor of the small intestine mimicking acute appendicitis: a case report and review of the literature. (27094797)
2016
8
Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report. (27846861)
2016
9
Inflammatory myofibroblastic tumor presenting as ileocecal intussusception-A case report. (27262346)
2016
10
Drastic initial response and subsequent response to two ALK inhibitors in a patient with a highly aggressive ALK-rearranged inflammatory myofibroblastic tumor arising in the pleural cavity. (27565932)
2016
11
Inflammatory Myofibroblastic Tumor in the Bladder: A Case Report. (27790120)
2016
12
Inflammatory Myofibroblastic Tumor of Liver Masquerading as Focal Nodular Hyperplasia in a Patient with Non-Cirrhotic Portal Hypertension and Biliary Pancreatitis. (27065695)
2016
13
Inflammatory myofibroblastic tumor of the left atrium in infant. (27526369)
2016
14
Recurrent retroperitoneal inflammatory myofibroblastic tumor: A case report. (27446466)
2016
15
Chromoplectic TPM3-ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib. (27742657)
2016
16
Myocardial Infarction Secondary to Inflammatory Myofibroblastic Tumor Obstruction of the Left Main: Treated With Primary PCI. (27800457)
2016
17
Inflammatory Myofibroblastic Tumor of the Heart in the Infant: Review of the Literature. (26989913)
2016
18
Inflammatory Myofibroblastic Tumor of the Bladder: 2 Rare Cases Managed with Laparoscopic Partial Cystectomy. (27974989)
2016
19
Inflammatory Myofibroblastic Tumor of the Lung. (27097710)
2016
20
Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review. (27443585)
2016
21
Complete resection of a huge hypervascular inflammatory myofibroblastic tumor in right hemithorax after embolization. (27286690)
2016
22
Appendiceal Inflammatory Myofibroblastic Tumor: A Rare Postoperative Finding. (27397035)
2016
23
Primary spinal extradural inflammatory myofibroblastic tumor: A rare cause of paraparesis. (27841217)
2016
24
Aggressive Metastatic Inflammatory Myofibroblastic Tumor After Allogeneic Stem Cell Transplant With Fatal Pulmonary Toxicity From Crizotinib. (27271810)
2016
25
Follow-Up Imaging of Inflammatory Myofibroblastic Tumor of the Uterus and Its Spontaneous Regression. (27110328)
2016
26
Fever,Weight Loss and Early Satiety due to Gastric Inflammatory Myofibroblastic Tumor; Case Report and Literature Review. (27252821)
2016
27
Diagnosing and Treating Inflammatory Myofibroblastic Tumor of the Bladder. (27293951)
2016
28
Inflammatory myofibroblastic tumor in the head of the pancreas with anorexia and vomiting in a 69-year-old man: A case report. (27446468)
2016
29
Inflammatory myofibroblastic tumor presenting as paraneoplastic pemphigus in a 7-year-old girl. (27051823)
2016
30
Inflammatory Myofibroblastic Tumor of the Larynx:A Case Report. (26878008)
2016
31
ALK-positive inflammatory myofibroblastic tumor harboring ALK gene rearrangement, occurring after allogeneic stem cell transplant in an adult male. (27155927)
2016
32
Inflammatory myofibroblastic tumor: A rare cause of invagination in adults. (27022387)
2016
33
Remission of ALK-negative primary pulmonary inflammatory myofibroblastic tumor on treatment with clarithromycin: A case report and review of the literature. (26998073)
2016
34
Febrile Illness in an Infant With an Intracardiac Inflammatory Myofibroblastic Tumor. (26798044)
2016
35
Laryngeal inflammatory myofibroblastic tumor (IMT): a case report and review of the literature. (27339455)
2016
36
ALK-rearranged Inflammatory Myofibroblastic Tumor of the Placenta, With Observations on Site of Origin. (27636888)
2016
37
Radiologic and Clinicopathologic Findings of Inflammatory Myofibroblastic Tumor. (27224222)
2016
38
Complete and Repeated Response of a Metastatic ALK-rearranged Inflammatory Myofibroblastic Tumor to Crizotinib in a Teenage Girl. (26808369)
2016
39
Neoadjuvant Treatment With Cyclooxygenase-2 Inhibitor and Prednisolone Allows Conservative Surgery for Inflammatory Myofibroblastic Tumor of the Bladder. (27322717)
2016
40
Anaplastic lymphoma kinase positive inflammatory myofibroblastic tumor of the urachus: A rare neoplasm in an unusual location. (26960648)
2016
41
An inflammatory myofibroblastic tumor of the small intestine in a 15-year-old girl. (28007682)
2016
42
Successful sleeve lobectomy of pediatric inflammatory myofibroblastic tumor. (27804248)
2016
43
Metastatic Inflammatory Myofibroblastic Tumor of the Spleen: A Case Report and Review of the Literature. (28018701)
2016
44
Inflammatory Myofibroblastic Tumor of the Kidney: A Rare Renal Tumor. (28050384)
2016
45
Inflammatory myofibroblastic tumor of carotid artery resulting in recurrent syncope: A case report. (27028414)
2016
46
Inflammatory myofibroblastic tumor of the small intestine: A case report. (27046103)
2016
47
A Case of Cutaneous Inflammatory Myofibroblastic Tumor. (27653445)
2016
48
Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement with bland cytological features mimicking desmoid-type fibromatosis: A case report and review of the literature. (26893756)
2016
49
Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor. (26933315)
2016
50
An isolated inflammatory myofibroblastic tumor of adrenal gland. (27806843)
2016

Variations for Inflammatory Myofibroblastic Tumor

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Expression for genes affiliated with Inflammatory Myofibroblastic Tumor

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Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

Pathways for genes affiliated with Inflammatory Myofibroblastic Tumor

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GO Terms for genes affiliated with Inflammatory Myofibroblastic Tumor

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Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle thin filament tropomyosinGO:000586210.1TPM3, TPM4
2focal adhesionGO:00059259.2ACTC1, CLTC, NPM1, TPM4, VIM
3cytosolGO:00058297.7ACTC1, CARS, CCND1, CLTC, DES, MDM2

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1complement receptor mediated signaling pathwayGO:000243010.7CR1, CR2
2mitotic G1 DNA damage checkpointGO:003157110.6CCND1, TP53
3movement of cell or subcellular componentGO:000692810.4TPM3, TPM4, VIM
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697710.3MDM2, NPM1, TP53
5muscle filament slidingGO:00300499.9ACTC1, DES, TPM3, TPM4, VIM
6positive regulation of cell proliferationGO:00082849.7CCND1, KIT, MDM2, NPM1, S100B
7positive regulation of gene expressionGO:00106289.6ACTC1, KIT, MDM2, TP53, VIM
8viral processGO:00160329.1MDM2, NPM1, RANBP2, TP53, VIM

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SUMO transferase activityGO:001978910.0MDM2, RANBP2
2identical protein bindingGO:00428029.4ALK, DES, MDM2, S100B, TP53, VIM
3protein kinase bindingGO:00199019.3ACVRL1, CCND1, CLTC, NPM1, TP53

Sources for Inflammatory Myofibroblastic Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet