MCID: INF058
MIFTS: 47

Inflammatory Myofibroblastic Tumor malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Inflammatory Myofibroblastic Tumor

About this section
Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 66UMLS, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Inflammatory Myofibroblastic Tumor:

Name: Inflammatory Myofibroblastic Tumor 11 46 13 52 66
Inflammatory Fibrosarcoma 46
 
Inflammatory Pseudotumor 46
Pseudotumor Inflammatory 48

Classifications:



External Ids:

Disease Ontology11 DOID:0050905
Orphanet52 ORPHA178342
UMLS via Orphanet67 C0334121

Summaries for Inflammatory Myofibroblastic Tumor

About this section
NIH Rare Diseases:46 An inflammatory myofibroblastic tumor (imt) is an uncommon, presumably benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. it usually develops in children or young adults, but can affect people of any age. an imt can occur in almost any part of the body but is most commonly found in the lung, orbit (eye socket), peritoneum (lining of the abdominal cavity and internal organs), and mesentery. signs and symptoms vary depending on the site of the tumor. some people with an imt are asymptomatic, while others may have nonspecific respiratory symptoms, fever, or pain. imts may recur, and occasionally become locally invasive and/or spread (metastasize) to other parts of the body. the underlying cause of imts is poorly understood. some cases have been linked to translocations involving the alk gene. treatment involves surgical removal when possible, although there are reports of treatment with oral steroids and radiation therapy. last updated: 2/8/2016

MalaCards based summary: Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to gastrointestinal stromal tumor and liver inflammatory pseudotumor, and has symptoms including pain and vestibulitis. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase), and among its related pathways are Sumoylation by RanBP2 regulates transcriptional repression and Cardiac muscle contraction. Affiliated tissues include lung, eye and liver, and related mouse phenotypes are muscle and cardiovascular system.

Disease Ontology:11 A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells.

Related Diseases for Inflammatory Myofibroblastic Tumor

About this section

Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1gastrointestinal stromal tumor29.3ACTC1, DES, KIT, S100B, TP53, VIM
2liver inflammatory pseudotumor11.2
3lymphangiomatosis10.9ACTC1, VIM
4myxoid liposarcoma of the ovary10.9ACTC1, VIM
5harding ataxia10.8DES, VIM
6infantile glycine encephalopathy10.8ACTC1, S100B
7hypotonia10.8S100B, VIM
8iridogoniodysgenesis and skeletal anomalies10.8ACTC1, VIM
9anaplastic oligoastrocytoma10.8S100B, VIM
10exstrophy-epispadias complex10.8S100B, VIM
11lymphocytic vasculitis10.7DES, VIM
12intravascular fasciitis10.7ACTC1, DES
13diffuse pulmonary fibrosis10.7ACTC1, S100B
14relapsing epidemic typhus10.7KIT, S100B
15mollaret meningitis10.7ACTC1, DES, VIM
16malignant glandular tumor of peripheral nerve sheath10.7ACTC1, DES, VIM
17xq12-q13.3 duplication syndrome10.7ACTC1, DES, KIT
18cerebrovascular disease10.7DES, S100B
19t-cell childhood acute lymphocytic leukemia10.7ACTC1, DES, VIM
20pineal parenchymal tumor of intermediate differenciation10.7ACTC1, S100B, VIM
21absence of fingerprints congenital milia10.7DES, S100B, VIM
22staphyloenterotoxemia10.7ACTC1, DES, VIM
23bartholin's gland benign neoplasm10.7DES, S100B, VIM
24malignant adenofibroma10.7DES, S100B, VIM
25pura syndrome10.7ACTC1, DES, KIT
26focal chorioretinitis10.6DES, KIT, VIM
27penile urethral cancer10.6CR1, CR2
28breast rhabdomyosarcoma10.6DES, KIT
29fraxf syndrome10.6S100B, VIM
30epithelioid cell melanoma10.6KIT, S100B, VIM
31renal tubular acidosis, distal, autosomal recessive10.6DES, S100B, VIM
32pleuropulmonary blastoma type 210.6ACTC1, DES, MDM2
33glucocorticoid-induced osteoporosis10.6ALK, TP53
34intermediate cell type ciliary body melanoma10.6CCND1, S100B
35acute panmyelosis with myelofibrosis10.5KIT, NPM1
36lymphangiosarcoma10.5ACTC1, DES, S100B, VIM
37chondroblastoma10.5ACTC1, DES, S100B, VIM
38pulmonary venoocclusive disease10.5ACTC1, DES, S100B, VIM
39gallbladder leiomyosarcoma10.5ACTC1, DES, S100B, VIM
40anus leiomyosarcoma10.5ACTC1, DES, S100B, VIM
41bickerstaff brainstem encephalitis10.5DES, S100B
42pancreatic intraductal papillary-mucinous adenoma10.5CR1, CR2
43parachordoma10.5ACTC1, DES, KIT, VIM
44megarbane jalkh syndrome10.5ACTC1, DES, S100B, VIM
45idiopathic subglottic tracheal stenosis10.5MDM2, VIM
46frontal sinus squamous cell carcinoma10.5ACTC1, DES, KIT, VIM
47vulvar liposarcoma10.5CR2, KIT, MDM2
48gastric cardia carcinoma10.5CR1, CR2, KIT
49sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes10.5CR1, CR2, S100B
50skin lipoma10.5ACTC1, DES, MDM2, VIM

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:



Diseases related to inflammatory myofibroblastic tumor

Symptoms for Inflammatory Myofibroblastic Tumor

About this section

UMLS symptoms related to Inflammatory Myofibroblastic Tumor:


pain, vestibulitis

Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

About this section

Drugs for Inflammatory Myofibroblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DoxilApproved June 1999Phase 2, Phase 3167631703
Synonyms:
Dox-SL
Doxil
 
Evacet
LipoDox
Pegylated Liposomal Doxorubicin Hydrochloride
liposomal doxorubicin
2Isophosphamide mustardPhase 2, Phase 3386
3
MechlorethaminePhase 2, Phase 336351-75-24033
Synonyms:
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
2,2'-dichloro-N-methyldiethylamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
302-70-5 (N-oxide, hydrochloride)
51-75-2
55-86-7 (HYDROCHLORIDE)
AC1L1H9H
Antimit
BRN 0605323
BSPBio_001947
Bis(2-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
C07115
C5H11Cl2N
CCRIS 447
CHEBI:28925
CHEMBL427
CID4033
Carolysine
Caryolysin
Caryolysine
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinum [INN-Latin]
Cloramin
Clormetina
Clormetina [INN-Spanish]
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
DivK1c_000759
EINECS 200-120-5
ENT-25294
Embechine
Embichin
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
 
KBioGR_001448
KBioSS_001369
LS-7559
MBA
Me chloroethamine
Mebichloramine
Mechlorethamine
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
MolPort-001-785-592
Mustargen
Mustine
Mustine note
Mutagen
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-lost
N-Methyl-lost [German]
N-methyl-bis(2-chloroethyl)amine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCI60_041682
NINDS_000759
NSC762
Nitol (*Hydrochloride*)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
SPBio_000496
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Spectrum_000889
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
T 1024
T-1024
TL 146
UNII-50D9XSG0VR
beta,Beta'-dichlorodiethyl-N-methylamine
beta,beta'-Dichlorodiethyl-N-methylamine
mechlorethamine
thyldiethylamine
β,β'-dichlorodiethyl-N-methylamine
4Alkylating AgentsPhase 2, Phase 34573
5
IfosfamidePhase 2, Phase 33863778-73-23690
Synonyms:
(+-)-Ifosfamid
(+-)-Ifosphamide
(+-)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
(D,L)-Ifosfamide
(R,S)-Ifosphamide
(R,S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd
2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis( 2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (8CI)
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
3,} 2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2- oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
36341-88-5
3778-73-2
84711-20-6
A 4942
AB00513932
AC-2113
AC1L1GHW
ASTA Z 4942
Ambap3778-73-2
Asta Z 4942
BPBio1_000865
BRN 0611835
BSPBio_000785
C07047
CAS-3778-73-2
CCRIS 352
CHEBI:5864
CHEMBL1024
CID3690
Cyfos
D00343
D007069
DB01181
EINECS 223-237-3
HMS1570H07
HMS2090M12
HMS2093N07
HSDB 7023
Holoxan
Holoxan 1000
I-Phosphamide
I06-0494
IFEX (TN)
Ifex
Ifosfamid
Ifosfamida
Ifosfamida [INN-Spanish]
Ifosfamide (JAN/USP/INN)
 
Ifosfamide Sterile
Ifosfamide [USAN:INN:BAN:JAN]
Ifosfamidum
Ifosfamidum [INN-Latin]
Ifosphamide
Ifsofamide
Iphosphamid
Iphosphamid(e)
Iphosphamide
Iso Endoxan
Iso-Endoxan
Isoendoxan
Isofosfamide
Isophosphamide
Isosfamide
LS-102
LS-99799
MJF 9325
MJF-9325
MLS002154021
Mitoxana
Mitoxana, Ifex, Ifosfamide
MolPort-003-666-704
N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylen ephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide
N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine
NCGC00016639-01
NCGC00179435-01
NCI-C01638
NCI60_000233
NPFAPI-04
NSC 109,724
NSC 109724
NSC-109,724
NSC-109724
NSC109,724
NSC109724
Naxamide
Prestwick0_000833
Prestwick1_000833
Prestwick2_000833
Prestwick3_000833
S1302_Selleck
SMR001233348
SPBio_002706
STL058690
UNII-UM20QQM95Y
WLN: T6NPOTJ AM2G BO B2G
Z 4942
Z-4942
Z4942
ifosfamide
isosfamide
{3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,
6
DoxorubicinPhase 2, Phase 3167623214-92-831703
Synonyms:
(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
111266-55-8
14-Hydroxydaunomycin
14-Hydroxydaunorubicine
14-hydroxydaunomycin
14-hydroxydaunorubicine
23214-92-8
23257-17-2
24385-08-8
25311-50-6
25316-40-9
25316-40-9 (hydrochloride)
29042-30-6
AC1L1M5T
AC1Q29OJ
ADM
ADR
Adriablastin
Adriacin (hydrochloride salt)
Adriamycin
Adriamycin PFS
Adriamycin PFS (hydrochloride salt)
Adriamycin RDF
Adriamycin RDF (hydrochloride salt)
Adriamycin Semiquinone
Adriamycin semiquinone
Adriblas tina
Adriblastin
Adriblastina
Adriblastina (TN)
Adriblastina (hydrochloride salt)
Aerosolized Doxorubicin
BPBio1_000502
BRD-K92093830-003-04-3
BSPBio_000456
BSPBio_001031
C01661
C27H29NO11
CCRIS 739
CHEBI:28748
CHEMBL179
CID31703
Caelyx
Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74
Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120
D03899
DB00997
DM2
DOX-SL
Doxil
Doxo
Doxorubicin
Doxorubicin (USAN/INN)
Doxorubicin HCl
 
Doxorubicin Hydrochloride
Doxorubicin [USAN:INN:BAN]
Doxorubicin citrate
Doxorubicin hydrochloride (hydrochloride salt)
Doxorubicin-P4/D10
Doxorubicin-P4/D10 conjugate
Doxorubicin-hLL1
Doxorubicin-hLL1 conjugate
Doxorubicina
Doxorubicina [INN-Spanish]
Doxorubicine
Doxorubicine [INN-French]
Doxorubicinum
Doxorubicinum [INN-Latin]
EINECS 245-495-6
FI 106
Farmablastina (hydrochloride salt)
HMS2089H06
HSDB 3070
Hydroxydaunomycin hydrochlor ide (hydrochloride salt)
Hydroxydaunomycin hydrochloride (hydrochloride salt)
Hydroxydaunorubicin
Hydroxydaunorubicin hydrochloride (hydrochloride salt)
JT9100000
LMPK13050001
LS-1029
LS-165655
MLS000759533
Myocet
NCI-C01514
NChemBio.2007.10-comp13
NDC 38242-874
NIOSH/JT9100000
NSC 123127
Prestwick0_000438
Prestwick1_000438
Prestwick2_000438
Prestwick3_000438
Probes1_000151
Probes2_000129
RDF Rubex
Resmycin
Rubex
Rubex (hydrochloride salt)
SMP1_000106
SPBio_002395
TLC D-99
ThermoDox
Triferric doxorubicin
UNII-80168379AG
adiblastine (hydrochloride salt)
adr iablatina (hydrochloride salt)
adriablastine (hydrochloride salt)
adriablatina (hydrochloride salt)
adriblatina (hydrochloride salt)
doxorubicin
nchembio809-comp5
7
CyclophosphamidePhase 2, Phase 3275650-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
8
CrizotinibPhase 297877399-52-511626560, 10366136, 10366137, 10366138, 10366139, 10366140, 10366141
Synonyms:
(R)-Crizotinib
C-Met/HGFR Tyrosine Kinase Inhibitor PF-02341066
C-Met/Hepatocyte Growth Factor Receptor Tyrosine Kinase Inhibitor PF-02341066
Crizotinib
Crizotinibum
 
MET Tyrosine Kinase Inhibitor PF-02341066
PF 2341066
PF-02341066
PF-2341066
Xalkori
crizotinib
9
ceritinibPhase 1361032900-25-6
Synonyms:
2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2- isopropylsulfonyl)phenyl) pyrimidine-2,4-diamine
LDK378
 
N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamide
Zykadia
céritinib

Interventional clinical trials:

idNameStatusNCT IDPhase
1Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by SurgeryRecruitingNCT02180867Phase 2, Phase 3
2CREATE: Cross-tumoral Phase 2 With CrizotinibRecruitingNCT01524926Phase 2
3Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung CancerRecruitingNCT01625234Phase 1, Phase 2
4Phase 2 Study Assessing Efficacy and Safety of Crizotinib in Patients Harboring an Alteration on ALK, MET or ROS1RecruitingNCT02034981Phase 2
5A Phase 1/2 Study of the Oral ALK/EGFR Inhibitor AP26113Active, not recruitingNCT01449461Phase 1, Phase 2
6Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)RecruitingNCT01742286Phase 1
7Cohort Study of IgG4RDRecruitingNCT01670695Phase 0

Search NIH Clinical Center for Inflammatory Myofibroblastic Tumor

Genetic Tests for Inflammatory Myofibroblastic Tumor

About this section

Anatomical Context for Inflammatory Myofibroblastic Tumor

About this section

MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

34
Lung, Eye, Liver, Bone, Trachea, Heart, Spleen

Animal Models for Inflammatory Myofibroblastic Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Inflammatory Myofibroblastic Tumor:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0ACTC1, ACVRL1, DES, KIT, MDM2, TP53
2MP:00053857.0ACTC1, ACVRL1, CCND1, DES, KIT, MDM2
3MP:00053766.6ACTC1, ACVRL1, ALK, CCND1, CR2, DES

Publications for Inflammatory Myofibroblastic Tumor

About this section

Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
A case report of inflammatory myofibroblastic tumor of urinary bladder. (27453664)
2016
2
Inflammatory myofibroblastic tumor of the small intestine mimicking acute appendicitis: a case report and review of the literature. (27094797)
2016
3
Inflammatory Myofibroblastic Tumor of the Placenta: A Report of a Novel Lesion in 2 Patients. (26262452)
2015
4
Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor. (25504840)
2015
5
Whether inflammatory myofibroblastic tumor of the thigh relapses after surgical excision? (26379986)
2015
6
FN1: A novel fusion partner of ALK in an inflammatory myofibroblastic tumor. (25682942)
2015
7
A primary inflammatory myofibroblastic tumor of the scapula in a child: imaging findings. (25307049)
2014
8
Primary inflammatory myofibroblastic tumor of the stomach in an adult woman: a case report and review of the literature. (23374227)
2013
9
Inflammatory myofibroblastic tumor of the temporal bone presenting with pulsatile tinnitus: a case report. (23787119)
2013
10
Pulmonary inflammatory myofibroblastic tumor and IgG4-related inflammatory pseudotumor: a diagnostic dilemma. (24100523)
2013
11
Inflammatory myofibroblastic tumor of parotid in infancy--a new entity. (23562234)
2013
12
Inflammatory myofibroblastic tumor of the esophagus treated by endoscopy. (23072221)
2013
13
Inflammatory Myofibroblastic Tumor of the Heart. (24369180)
2013
14
Inflammatory myofibroblastic tumor of the stomach in an adult female--report of a rare case and review of the literature. (22965515)
2012
15
Rare gastric inflammatory myofibroblastic tumor in an adult woman: a case report with review of the literature. (22570660)
2012
16
Invasive inflammatory myofibroblastic tumor of the spleen treated with partial splenectomy in a child. (22469943)
2012
17
Inflammatory myofibroblastic tumor of the bladder in a 3-year-old boy. (21741683)
2012
18
A rare case of an inflammatory myofibroblastic tumor in a middle-aged female. (23091756)
2012
19
Inflammatory myofibroblastic tumor of the lung in children: anaplastic lymphoma kinase (ALK) expression and clinico-pathological correlation. (22280150)
2012
20
Abdominal inflammatory myofibroblastic tumor: report on four cases and review of literature. (23056847)
2011
21
Inflammatory myofibroblastic tumor invading pulmonary trunk with multiple mediastinal lymph node metastasis. (21718820)
2011
22
Inflammatory myofibroblastic tumor of the liver in an elderly woman following a second liver biopsy: a case report. (22111473)
2011
23
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK. (21164297)
2011
24
Pulmonary inflammatory myofibroblastic tumor invading the gastroesophageal junction. (20417808)
2010
25
Inflammatory myofibroblastic tumor of the infratemporal fossa. (20551572)
2010
26
Inflammatory myofibroblastic tumor in the intradural extramedullary space of the lumbar spine with spondylolisthesis: case report and review of the literature. (19941012)
2010
27
Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature. (18436455)
2009
28
A case of inflammatory myofibroblastic tumor of the kidney with cystic change. (19470689)
2009
29
Inflammatory myofibroblastic tumor in the larynx. (18852998)
2008
30
An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features. (18701132)
2008
31
Inflammatory myofibroblastic tumor of the lung: recurrence after steroid treatment. (18728547)
2008
32
Rapid regression of duodenal inflammatory myofibroblastic tumor after intravenous ketorolac: case report and review of the literature. (18558206)
2008
33
Renal inflammatory myofibroblastic tumor: a rare tumor indistinguishable from renal cell carcinomaa89report of two cases. (17963086)
2007
34
Inflammatory myofibroblastic tumor of the midesophagus. (18363157)
2007
35
Inflammatory myofibroblastic tumor of the abdominal wall simulating rhabdomyosarcoma: report of a case. (17387574)
2007
36
Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. (17414097)
2007
37
Inflammatory myofibroblastic tumor of the liver. (17090200)
2006
38
Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature. (17008862)
2006
39
Acute abdomen caused by a perforated inflammatory myofibroblastic tumor of the jejunum. (16774173)
2006
40
Inflammatory myofibroblastic tumor of the larynx with anaplastic lymphoma kinase (ALK) protein overexpression. A case report. (17168442)
2006
41
Inflammatory myofibroblastic tumor presenting as a pancreatic mass: a case report and review of the literature. (15365204)
2004
42
Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor. (13679433)
2003
43
Inflammatory myofibroblastic tumor of the left ventricle in an older adult. (12822653)
2003
44
Monophasic sarcomatoid carcinoma of the scalp: a case mimicking inflammatory myofibroblastic tumor and a review of cutaneous spindle cell tumors with myofibroblastic differentiation. (12834489)
2003
45
Inflammatory myofibroblastic tumor of the mediastinum presenting as superior vena cava syndrome. (14502173)
2003
46
Inflammatory myofibroblastic tumor presenting with tracheal obstruction in a pregnant woman. (12430129)
2002
47
ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family? (11284039)
2001
48
Inflammatory myofibroblastic tumor of small bowel wall in childhood: Report of a case and a review of the literature. (11148464)
2001
49
Sarcomatoid variant of anaplastic large cell lymphoma with cytoplasmic ALK and alpha-smooth muscle actin expression: a mimic of inflammatory myofibroblastic tumor. (11438487)
2001
50
Pathology forum: quiz case 1. Diagnosis: inflammatory myofibroblastic tumor (IMT). (10889005)
2000

Variations for Inflammatory Myofibroblastic Tumor

About this section

Expression for genes affiliated with Inflammatory Myofibroblastic Tumor

About this section
Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

Pathways for genes affiliated with Inflammatory Myofibroblastic Tumor

About this section

GO Terms for genes affiliated with Inflammatory Myofibroblastic Tumor

About this section

Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle thin filament tropomyosinGO:000586210.8TPM3, TPM4
2focal adhesionGO:00059259.4ACTC1, CLTC, NPM1, TPM4, VIM
3cytosolGO:00058296.8ACTC1, CARS, CCND1, CLTC, DES, MDM2

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:003157110.4CCND1, TP53
2complement receptor mediated signaling pathwayGO:000243010.4CR1, CR2
3DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697710.1MDM2, NPM1, TP53
4movement of cell or subcellular componentGO:00069289.4TPM3, TPM4, VIM
5viral processGO:00160329.3MDM2, NPM1, RANBP2, TP53, VIM
6muscle filament slidingGO:00300499.1ACTC1, DES, TPM3, TPM4, VIM
7positive regulation of gene expressionGO:00106288.9ACTC1, KIT, MDM2, TP53, VIM
8positive regulation of cell proliferationGO:00082848.9CCND1, KIT, MDM2, NPM1, S100B

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SUMO transferase activityGO:001978910.6MDM2, RANBP2
2protein kinase bindingGO:00199019.1ACVRL1, CCND1, CLTC, NPM1, TP53
3identical protein bindingGO:00428028.4ALK, DES, MDM2, S100B, TP53, VIM

Sources for Inflammatory Myofibroblastic Tumor

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet