MCID: INF058
MIFTS: 42

Inflammatory Myofibroblastic Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Inflammatory Myofibroblastic Tumor

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NIH Rare Diseases:41 Inflammatory myofibroblastic tumor is made up of specific cells called myofibroblastic spindle cells. this tumor can occur in many different parts of the body, but it occurs most frequently in the lungs, soft tisues, or internal organs. inflammatory myofibroblastic tumor usually develops in children or young adults, although it can affect people of any age. this type of tumor tends to recur in the same location, but it rarely spreads (metastasizes) to other parts of the body. approximately 50% of inflammatory myofibroblastic tumors have rearrangements of the alk gene on chromosome 2. treatment typically involves surgery to remove the tumor. last updated: 11/2/2010

MalaCards based summary: Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to fibrosarcoma and fibroma. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Adrenergic signaling in cardiomyocytes and Cardiac muscle contraction. The compounds orcein and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone.

Disease Ontology:9 A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells.

Aliases & Classifications for Inflammatory Myofibroblastic Tumor

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 47Orphanet, 60UMLS, 43Novoseek, 61UMLS via Orphanet
See all sources

Inflammatory Myofibroblastic Tumor, Aliases & Descriptions:

Name: Inflammatory Myofibroblastic Tumor 9 41 47 60
Inflammatory Fibrosarcoma 41
 
Inflammatory Pseudotumor 41
Pseudotumor Inflammatory 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 47 
Rare tumors


External Ids:

Disease Ontology9 DOID:0050905
Orphanet47 178342
UMLS via Orphanet61 C0334121

Related Diseases for Inflammatory Myofibroblastic Tumor

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Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1fibrosarcoma30.9ACTC1, DES, ALK
2fibroma30.9DES, ACTC1
3spindle cell carcinoma30.7ACTC1, DES
4wilms tumor30.7DES, ACTC1
5fibrous histiocytoma30.7DES, ACTC1
6anaplastic large cell lymphoma30.6ALK, TPM3, TPM4, ACVRL1
7rhabdomyosarcoma30.6ALK, ACTC1, ACVRL1, DES
8angiomyolipoma30.4DES, ACTC1
9embryonal rhabdomyosarcoma30.3ACTC1, DES, ALK, ACVRL1
10sarcoma30.3DES, CR2, ALK, ACTC1, ACVRL1
11pancreatitis10.7
12intussusception10.6
13fasciitis10.5ACTC1
14laryngitis10.5
15infantile myofibromatosis10.4DES
16renal cell carcinoma10.4
17esophagitis10.4
18mediastinitis10.4
19peritonitis10.4
20alexander disease10.4DES
21cholangitis10.4
22lymphomatoid papulosis10.3ALK, ACVRL1
23cholangiocarcinoma10.3
24follicular dendritic cell sarcoma10.3
25dendritic cell sarcoma10.3
26systemic lupus erythematosus10.3
27hepatocellular carcinoma10.3
28sinusitis10.3
29pemphigus10.3
30lupus erythematosus10.3
31meningitis10.3
32prostatitis10.3
33thyroiditis10.3
34tuberculosis10.3
35paraneoplastic pemphigus10.3
36epithelioid leiomyosarcoma10.3ACTC1, DES
37pseudosarcomatous fibromatosis10.3ACTC1, DES
38spindle cell sarcoma10.3DES, ACTC1
39desmoid disease, hereditary10.3DES, ACTC1
40cutaneous fibrous histiocytoma10.3ACTC1, DES
41adenosarcoma10.3DES, ACTC1
42dermatofibrosarcoma protuberans10.3ACTC1, DES
43endometrial stromal sarcoma10.3ACTC1, DES
44rhabdoid tumor10.3ACTC1, DES
45nemaline myopathy10.3TPM3, ACTC1
46sclerosing cholangitis10.3
47focal myositis10.3
48hemangiopericytoma10.3DES, ACTC1
49reticulosarcoma10.3TPM3, ALK
50glomus tumor10.3DES, ACTC1

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:



Diseases related to inflammatory myofibroblastic tumor

Symptoms for Inflammatory Myofibroblastic Tumor

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Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

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Drug clinical trials:

Search ClinicalTrials for Inflammatory Myofibroblastic Tumor

Search NIH Clinical Center for Inflammatory Myofibroblastic Tumor

Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

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MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

31
Lung, Liver, Bone, Trachea, Spleen, Heart, Breast, Colon, Lymph node, Kidney, Pancreas, Uterus, Skin, Bone marrow, Small intestine, Thyroid, Prostate, Testes, Tongue, Brain, Smooth muscle, Testis, B cells, Appendix

Animal Models for Inflammatory Myofibroblastic Tumor or affiliated genes

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Publications for Inflammatory Myofibroblastic Tumor

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Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50)    (show all 456)
idTitleAuthorsYear
1
Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor. (25504840)
2015
2
Inflammatory myofibroblastic tumor: Clinical, morphological, immunohistochemical and molecular features of a pediatric case. (25149504)
2014
3
Inflammatory Myofibroblastic Tumor of the Urinary Bladder: The Role of IgG4 and the Comparison of Two Immunohistochemical Antibodies and Fluorescence in Situ Hybridization for the Detection of ALK Alterations. (25406945)
2014
4
Inflammatory myofibroblastic tumor of the upper alveolus: A rare entity presenting as a jaw swelling. (25593882)
2014
5
Malignant inflammatory myofibroblastic tumor of the prostate. (23401456)
2013
6
Primary inflammatory myofibroblastic tumor of the stomach in an adult woman: a case report and review of the literature. (23374227)
2013
7
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report. (24273608)
2013
8
Successful Sleeve Lobectomy of Inflammatory Myofibroblastic Tumor in a 4-year-old Child. (23445794)
2013
9
Inflammatory myofibroblastic tumor of the temporal bone presenting with pulsatile tinnitus: a case report. (23787119)
2013
10
A case of recurrent pulmonary inflammatory myofibroblastic tumor with aggressive metastasis after complete resection. (24265646)
2013
11
Inflammatory myofibroblastic tumor of trachea. (23328150)
2013
12
Fusion of dynactin 1 to anaplastic lymphoma kinase in inflammatory myofibroblastic tumor. (22658521)
2012
13
Inflammatory myofibroblastic tumor of the stomach in an adult female--report of a rare case and review of the literature. (22965515)
2012
14
Regression of an inflammatory myofibroblastic tumor of the porta-hepatis with steroid drugs. (22693097)
2012
15
Rare gastric inflammatory myofibroblastic tumor in an adult woman: a case report with review of the literature. (22570660)
2012
16
Carboplatin plus paclitaxel in the successful treatment of advanced inflammatory myofibroblastic tumor. (22975556)
2012
17
Invasive inflammatory myofibroblastic tumor of the spleen treated with partial splenectomy in a child. (22469943)
2012
18
Inflammatory myofibroblastic tumor of the skin grossly mimicking squamous cell carcinoma: a case report. (21545500)
2012
19
Bilateral simultaneous inflammatory myofibroblastic tumor of the lung with distant metastatic spread. (21606052)
2011
20
Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification. (21430068)
2011
21
Rubbery palatal mass. Inflammatory myofibroblastic tumor. (21903528)
2011
22
Multiorgan involvement in HHV-8-positive multifocal inflammatory myofibroblastic tumor. (21796573)
2011
23
Abdominal inflammatory myofibroblastic tumor: report on four cases and review of literature. (23056847)
2011
24
Pulmonary inflammatory myofibroblastic tumor invading the gastroesophageal junction. (20417808)
2010
25
Inflammatory myofibroblastic tumor of the esophagus. (20103355)
2010
26
Inflammatory myofibroblastic tumor presenting as an abdominal wall mass in an adult patient. (20622374)
2010
27
Inflammatory myofibroblastic tumor of the infratemporal fossa. (20551572)
2010
28
Clinicopathologic study of sinonasal inflammatory myofibroblastic tumor]. (20450762)
2010
29
Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature. (18436455)
2009
30
Inflammatory myofibroblastic tumor in the larynx. (18852998)
2008
31
An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features. (18701132)
2008
32
Case report: inflammatory myofibroblastic tumor of the duodenum. (19142589)
2008
33
Renal inflammatory myofibroblastic tumor: a rare tumor indistinguishable from renal cell carcinomaa89report of two cases. (17963086)
2007
34
Inflammatory myofibroblastic tumor of the midesophagus. (18363157)
2007
35
Primary renal inflammatory myofibroblastic tumor. (16401931)
2006
36
Inflammatory myofibroblastic tumor of the renal pelvis]. (16479987)
2006
37
A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining]. (16758729)
2006
38
Inflammatory myofibroblastic tumor of the liver. (17090200)
2006
39
Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature. (17008862)
2006
40
Acute abdomen caused by a perforated inflammatory myofibroblastic tumor of the jejunum. (16774173)
2006
41
Inflammatory myofibroblastic tumor (inflammatory pseudotumor) of the breast. (15676017)
2005
42
Inflammatory myofibroblastic tumor associated with renal cell carcinoma. (16230166)
2005
43
Inflammatory myofibroblastic tumor presenting as a pancreatic mass: a case report and review of the literature. (15365204)
2004
44
Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor. (13679433)
2003
45
Inflammatory myofibroblastic tumor of the left ventricle in an older adult. (12822653)
2003
46
Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. (12218210)
2002
47
Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. (11684952)
2001
48
ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family? (11284039)
2001
49
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. (10383129)
1999
50
Renal failure resulting from infiltration by inflammatory myofibroblastic tumor responsive to corticosteroid therapy. (10074585)
1998

Variations for Inflammatory Myofibroblastic Tumor

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Expression for genes affiliated with Inflammatory Myofibroblastic Tumor

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Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

Pathways for genes affiliated with Inflammatory Myofibroblastic Tumor

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Pathways related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TPM3, TPM4, ACTC1
29.3TPM4, TPM3, ACTC1
39.2CLTC, ACTC1, DES
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
8.8DES, TPM4, TPM3, ACTC1
5
Show member pathways
8.8DES, TPM4, TPM3, ACTC1

Compounds for genes affiliated with Inflammatory Myofibroblastic Tumor

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Sources:
43Novoseek, 49PharmGKB, 24HMDB, 12DrugBank
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Compounds related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

(show all 11)
idCompoundScoreTop Affiliating Genes
1orcein439.7ACTC1, DES
2[alcl]439.7ALK, ACVRL1
3s 100439.6DES, ACTC1
4reticulin439.6ACTC1, DES
5mucicarmine439.6ACTC1, DES
6b 723439.4DES, ACTC1
7hematoxylin439.1DES, ACTC1, CR2
8streptavidin439.0CR2, DES
9paraffin438.8CR2, ALK, ACTC1, DES
10tyrosine438.2CR2, ALK, ACTC1, TPM3, DES
11calcium43 49 24 1210.8CR2, CARS, ACTC1, CLTC, TPM3, TPM4

GO Terms for genes affiliated with Inflammatory Myofibroblastic Tumor

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Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle thin filament tropomyosinGO:000586210.0TPM3, TPM4
2podosomeGO:00021029.8TPM4, TPM3
3stress fiberGO:00017259.8TPM4, TPM3
4filamentous actinGO:00319419.7TPM3, TPM4
5cortical cytoskeletonGO:00308639.5TPM4, TPM3
6extracellular vesicular exosomeGO:00700628.2ACTC1, CLTC, ALK, TPM3, CR2, TPM4
7cytosolGO:00058298.0DES, TPM4, TPM3, CLTC, ACTC1, CARS

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:00069369.3TPM3, TPM4, DES
2muscle filament slidingGO:00300498.5ACTC1, TPM3, TPM4, DES

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:00083079.4SYNM, TPM4

Products for genes affiliated with Inflammatory Myofibroblastic Tumor

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Sources for Inflammatory Myofibroblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet