MCID: INF058
MIFTS: 50

Inflammatory Myofibroblastic Tumor malady

Rare diseases, Cancer diseases categories
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Summaries for Inflammatory Myofibroblastic Tumor

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NIH Rare Diseases:42 Inflammatory myofibroblastic tumor is made up of specific cells called myofibroblastic spindle cells. this tumor can occur in many different parts of the body, but it occurs most frequently in the lungs, soft tisues, or internal organs. inflammatory myofibroblastic tumor usually develops in children or young adults, although it can affect people of any age. this type of tumor tends to recur in the same location, but it rarely spreads (metastasizes) to other parts of the body. approximately 50% of inflammatory myofibroblastic tumors have rearrangements of the alk gene on chromosome 2. treatment typically involves surgery to remove the tumor. last updated: 11/2/2010

MalaCards based summary: Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to fibroma and fibrosarcoma. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Adrenergic signaling in cardiomyocytes and Cardiac muscle contraction. The compounds orcein and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone.

Disease Ontology:8 A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells.

Wikipedia:65 Inflammatory myofibroblastic tumour is a lesional pattern of inflammatory pseudotumour, as plasma cell... more...

Aliases & Classifications for Inflammatory Myofibroblastic Tumor

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 44Novoseek, 63UMLS via Orphanet
See all sources

Inflammatory Myofibroblastic Tumor, Aliases & Descriptions:

Name: Inflammatory Myofibroblastic Tumor 8 42 48 62
Inflammatory Fibrosarcoma 42
 
Inflammatory Pseudotumor 42
Pseudotumor Inflammatory 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 48 
Rare tumors


External Ids:

Disease Ontology8 DOID:0050905
UMLS via Orphanet63 C0334121

Related Diseases for Inflammatory Myofibroblastic Tumor

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Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1fibroma30.9DES, ACTC1
2fibrosarcoma30.8ALK, ACTC1, DES
3spindle cell carcinoma30.7ACTC1, DES
4fibrous histiocytoma30.7DES, ACTC1
5anaplastic large cell lymphoma30.6ALK, ACVRL1, TPM3, TPM4
6sarcoma30.5DES, ACVRL1, ACTC1, ALK, CR2
7angiomyolipoma30.5ACTC1, DES
8rhabdomyosarcoma30.4DES, ACVRL1, ACTC1, ALK
9pancreatitis10.6
10fasciitis10.5ACTC1
11infantile myofibromatosis10.4DES
12alexander disease10.4DES
13renal cell carcinoma10.4
14intussusception10.4
15esophagitis10.4
16laryngitis10.4
17mediastinitis10.4
18peritonitis10.4
19lymphomatoid papulosis10.4ACVRL1, ALK
20cholangiocarcinoma10.3
21sclerosing cholangitis10.3
22follicular dendritic cell sarcoma10.3
23cholangitis10.3
24dendritic cell sarcoma10.3
25epithelioid leiomyosarcoma10.3DES, ACTC1
26hepatocellular carcinoma10.3
27sinusitis10.3
28systemic lupus erythematosus10.3
29pemphigus10.3
30lupus erythematosus10.3
31meningitis10.3
32prostatitis10.3
33thyroiditis10.3
34tuberculosis10.3
35paraneoplastic pemphigus10.3
36pseudosarcomatous fibromatosis10.3DES, ACTC1
37spindle cell sarcoma10.3DES, ACTC1
38desmoid tumor10.3DES, ACTC1
39cutaneous fibrous histiocytoma10.3ACTC1, DES
40wilms tumor10.3ACTC1, DES
41adenosarcoma10.3DES, ACTC1
42dermatofibrosarcoma protuberans10.3DES, ACTC1
43endometrial stromal sarcoma10.3ACTC1, DES
44rhabdoid tumor10.3ACTC1, DES
45nemaline myopathy10.3TPM3, ACTC1
46hemangiopericytoma10.3DES, ACTC1
47focal myositis10.3
48reticulosarcoma10.3TPM3, ALK
49paraganglioma10.3DES, ACTC1
50alveolar rhabdomyosarcoma10.3DES, ALK

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:



Diseases related to inflammatory myofibroblastic tumor

Symptoms for Inflammatory Myofibroblastic Tumor

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Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

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Drug clinical trials:

Search ClinicalTrials for Inflammatory Myofibroblastic Tumor

Search NIH Clinical Center for Inflammatory Myofibroblastic Tumor

Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

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MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

32
Lung, Liver, Bone, Heart, Trachea, Spleen, Breast, Lymph node, Kidney, Pancreas, Colon, Uterus, Skin, Bone marrow, Small intestine, Thyroid, Prostate, Testes, Tongue, Brain, Smooth muscle, Testis, B cells, Appendix

Animal Models for Inflammatory Myofibroblastic Tumor or affiliated genes

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Publications for Inflammatory Myofibroblastic Tumor

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Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50)    (show all 438)
idTitleAuthorsYear
1
Inflammatory myofibroblastic tumor: Clinical, morphological, immunohistochemical and molecular features of a pediatric case. (25149504)
2014
2
Inflammatory Myofibroblastic Tumor of the Urinary Bladder: The Role of IgG4 and the Comparison of Two Immunohistochemical Antibodies and Fluorescence in Situ Hybridization for the Detection of ALK Alterations. (25406945)
2014
3
Malignant inflammatory myofibroblastic tumor of the prostate. (23401456)
2013
4
Primary inflammatory myofibroblastic tumor of the stomach in an adult woman: a case report and review of the literature. (23374227)
2013
5
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report. (24273608)
2013
6
Successful Sleeve Lobectomy of Inflammatory Myofibroblastic Tumor in a 4-year-old Child. (23445794)
2013
7
Inflammatory myofibroblastic tumor of the temporal bone presenting with pulsatile tinnitus: a case report. (23787119)
2013
8
A case of recurrent pulmonary inflammatory myofibroblastic tumor with aggressive metastasis after complete resection. (24265646)
2013
9
Inflammatory myofibroblastic tumor of trachea. (23328150)
2013
10
Fusion of dynactin 1 to anaplastic lymphoma kinase in inflammatory myofibroblastic tumor. (22658521)
2012
11
Inflammatory myofibroblastic tumor of the stomach in an adult female--report of a rare case and review of the literature. (22965515)
2012
12
Regression of an inflammatory myofibroblastic tumor of the porta-hepatis with steroid drugs. (22693097)
2012
13
Rare gastric inflammatory myofibroblastic tumor in an adult woman: a case report with review of the literature. (22570660)
2012
14
Carboplatin plus paclitaxel in the successful treatment of advanced inflammatory myofibroblastic tumor. (22975556)
2012
15
Invasive inflammatory myofibroblastic tumor of the spleen treated with partial splenectomy in a child. (22469943)
2012
16
Inflammatory myofibroblastic tumor of the skin grossly mimicking squamous cell carcinoma: a case report. (21545500)
2012
17
Bilateral simultaneous inflammatory myofibroblastic tumor of the lung with distant metastatic spread. (21606052)
2011
18
Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification. (21430068)
2011
19
Rubbery palatal mass. Inflammatory myofibroblastic tumor. (21903528)
2011
20
Multiorgan involvement in HHV-8-positive multifocal inflammatory myofibroblastic tumor. (21796573)
2011
21
Abdominal inflammatory myofibroblastic tumor: report on four cases and review of literature. (23056847)
2011
22
Pulmonary inflammatory myofibroblastic tumor invading the gastroesophageal junction. (20417808)
2010
23
Inflammatory myofibroblastic tumor of the esophagus. (20103355)
2010
24
Inflammatory myofibroblastic tumor presenting as an abdominal wall mass in an adult patient. (20622374)
2010
25
Inflammatory myofibroblastic tumor of the infratemporal fossa. (20551572)
2010
26
Clinicopathologic study of sinonasal inflammatory myofibroblastic tumor]. (20450762)
2010
27
Asymptomatic inflammatory myofibroblastic tumor of the heart: immunohistochemical profile, differential diagnosis, and review of the literature. (18436455)
2009
28
Inflammatory myofibroblastic tumor in the larynx. (18852998)
2008
29
An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features. (18701132)
2008
30
Case report: inflammatory myofibroblastic tumor of the duodenum. (19142589)
2008
31
Renal inflammatory myofibroblastic tumor: a rare tumor indistinguishable from renal cell carcinomaa89report of two cases. (17963086)
2007
32
Inflammatory myofibroblastic tumor of the midesophagus. (18363157)
2007
33
Inflammatory myofibroblastic tumor of the bladder in children: what can be expected? (17443333)
2007
34
Primary renal inflammatory myofibroblastic tumor. (16401931)
2006
35
Inflammatory myofibroblastic tumor of the renal pelvis]. (16479987)
2006
36
A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining]. (16758729)
2006
37
Inflammatory myofibroblastic tumor of the liver. (17090200)
2006
38
Small bowel intussusception by local recurrence of an inflammatory myofibroblastic tumor: report of a case and review of the literature. (17008862)
2006
39
Acute abdomen caused by a perforated inflammatory myofibroblastic tumor of the jejunum. (16774173)
2006
40
Inflammatory myofibroblastic tumor (inflammatory pseudotumor) of the breast. (15676017)
2005
41
Inflammatory myofibroblastic tumor associated with renal cell carcinoma. (16230166)
2005
42
Inflammatory myofibroblastic tumor presenting as a pancreatic mass: a case report and review of the literature. (15365204)
2004
43
Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor. (13679433)
2003
44
Inflammatory myofibroblastic tumor of the left ventricle in an older adult. (12822653)
2003
45
Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. (12218210)
2002
46
Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor. (11485898)
2001
47
Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. (11684952)
2001
48
ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family? (11284039)
2001
49
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. (10383129)
1999
50
Renal failure resulting from infiltration by inflammatory myofibroblastic tumor responsive to corticosteroid therapy. (10074585)
1998

Variations for Inflammatory Myofibroblastic Tumor

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Expression for genes affiliated with Inflammatory Myofibroblastic Tumor

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Expression patterns in normal tissues for genes affiliated with Inflammatory Myofibroblastic Tumor

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Pathways for genes affiliated with Inflammatory Myofibroblastic Tumor

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Pathways related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ACTC1, TPM3, TPM4
29.3TPM4, TPM3, ACTC1
39.2ACTC1, CLTC, DES
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.8ACTC1, TPM3, TPM4, DES
5
Show member pathways
8.8ACTC1, TPM3, TPM4, DES

Compounds for genes affiliated with Inflammatory Myofibroblastic Tumor

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Sources:
44Novoseek, 50PharmGKB, 24HMDB, 11DrugBank
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Compounds related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1orcein449.7ACTC1, DES
2[alcl]449.7ALK, ACVRL1
3s 100449.6DES, ACTC1
4reticulin449.6ACTC1, DES
5mucicarmine449.6ACTC1, DES
6b 723449.4DES, ACTC1
7hematoxylin449.1DES, ACTC1, CR2
8streptavidin449.0CR2, DES
9paraffin448.8CR2, ALK, ACTC1, DES
10tyrosine448.2CR2, ALK, ACTC1, TPM3, DES
11calcium44 50 24 1110.8CR2, CARS, ACTC1, CLTC, TPM3, TPM4

GO Terms for genes affiliated with Inflammatory Myofibroblastic Tumor

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Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle thin filament tropomyosinGO:00586210.0TPM3, TPM4
2podosomeGO:0021029.8TPM3, TPM4
3stress fiberGO:0017259.8TPM3, TPM4
4filamentous actinGO:0319419.7TPM4, TPM3
5cortical cytoskeletonGO:0308639.5TPM3, TPM4
6extracellular vesicular exosomeGO:0700628.2TPM4, TPM3, CLTC, ACTC1, ALK, CR2
7cytosolGO:0058298.0DES, TPM4, TPM3, CLTC, ACTC1, CARS

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:0069369.3TPM3, TPM4, DES
2muscle filament slidingGO:0300498.5ACTC1, TPM3, TPM4, DES

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:0083079.4SYNM, TPM4

Products for genes affiliated with Inflammatory Myofibroblastic Tumor

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Sources for Inflammatory Myofibroblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet