FLU
MCID: INF038
MIFTS: 69

Influenza (FLU) malady

Summaries for Influenza

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. most people with the flu recover on their own without medical care. people with mild cases of the flu should stay home and avoid contact with others, except to get medical care. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. the main way to keep from getting the flu is to get a yearly flu vaccine. good hygiene, including hand washing, can also help. nih: national institute of allergy and infectious diseases

MalaCards: Influenza, also known as FLU, is related to pneumonia and hepatitis, and has symptoms including fever, chills and runny nose. An important gene associated with Influenza is MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)), and among its related pathways are Influenza A and Interferon Signaling. The drug influenza neuraminidase inhibitor [epc] and the compounds cysteine and lipid have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, t cells and lung, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

CDC:3 Flu activity is low in most of the United States, but a wave of influenza B virus activity is affecting parts of the country. It's possible that significant flu activity could continue into May. CDC still recommends that people get a flu vaccine if they have not yet this season. And remember that flu antiviral drugs are a second line of defense to treat flu illness. People at high risk of serious flu illness should call a health care provider if they get flu symptoms.

Wikipedia:63 Influenza, commonly known as \"the flu\", is an infectious disease of birds and mammals caused by RNA... more...

Aliases & Classifications for Influenza

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Aliases & Descriptions:

influenza 8 10 44 60
flu 8 33
influenza with non-respiratory manifestation 8
influenza with other manifestations nos 8
influenza with other manifestations 8


External Ids:

Disease Ontology8 DOID:8469
ICD9CM27 487
MeSH34 D007251
NCIt39 C53482

Related Diseases for Influenza

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17GeneCards, 18GeneDecks
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Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 398)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.2SFTPD, NEU1, XDH, CXCL10
2hepatitis30.9IFNB1, XDH, CXCL10
3newcastle disease30.9IFNB1, NEU1, IVNS1ABP, CXCL10
4meningitis30.8CXCL10
5hepatitis b30.8MX1, CXCL10, IFNG
6vaccinia30.5FURIN
7respiratory failure30.5SFTPD
8arthritis30.5PTPN11, MX1, CXCL10, IVNS1ABP, IFNG
9mumps30.4NEU1
10measles30.4MX1, IFNB1
11encephalitis30.4MX1, CXCL10
12asthma30.3SFTPD, IFNG, IFNB1, NEU1, XDH, CXCL10
13severe acute respiratory syndrome30.3CXCL10
14aspergillosis30.3SFTPD, IFNG
15cystic fibrosis30.3FURIN, SFTPD
16rheumatoid arthritis30.2SFTPD, IFNG, IFNB1, IVNS1ABP, CXCL10, PTPN11
17systemic lupus erythematosus30.2PTPN11, MX1, CXCL10, IFNB1, IFNG
18hemophagocytic lymphohistiocytosis30.2IFNB1, MX1
19lupus erythematosus30.2MX1
20herpes simplex30.1MX1, CXCL10, NEU1, IFNB1
21chagas disease30.0NEU1
22hepatitis c29.9IFNG, IFNB1, CXCL10, MX1
23dermatomyositis29.9SFTPD, MX1
24allergic asthma29.9IFNB1, IFNG, SFTPD
25melanoma29.8IFNG, IFNB1, PDPN, NEU1, MAGEA3, XDH
26adenocarcinoma29.8SFTPD, IFNB1, PDPN, MAGEA3, CXCL10, FURIN
27malaria29.8XDH, NEU1, IFNG
28tuberculosis29.8SFTPD, IFNG, IFNB1, CXCL10
29diabetes mellitus29.8PTPN11, NEU1
30viral infectious disease29.8IFNG, IFNB1, NEU1, IVNS1ABP, XDH, CXCL10
31skin disease29.8SFTPD, IFNG, CXCL10, MX1
32alopecia areata29.8IFNG
33multiple sclerosis29.6IFNG, IFNB1, XDH, CXCL10, MX1
34sepsis29.6SFTPD, NEU1, XDH, FURIN
35kaposi's sarcoma29.6CXCL10, PDPN, IFNB1
36uveitis29.6CXCL10, IFNG
37sarcoidosis29.6SFTPD, IFNG, CXCL10
38japanese encephalitis29.6PTPN11, IVNS1ABP
39neutropenia29.6CXCL10, IFNB1
40lichen planus29.6MX1
41venezuelan equine encephalitis29.6FURIN
42bronchiolitis obliterans29.6CXCL10
43chronic inflammatory demyelinating polyradiculoneuropathy29.6IFNB1
44avian influenza11.1
45swine influenza11.1
46tetanus10.7
47pertussis10.6
48diphtheria10.6
49epiglottitis10.6
50hepatitis a10.5

Graphical network of the top 20 diseases related to Influenza:



Diseases related to influenza

Clinical Features for Influenza

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 8)
  • fever
  • chills
  • runny nose
  • muscle pains
  • sore throat
  • weakness
  • severe headache
  • cough

Drugs & Therapeutics for Influenza

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Influenza

Drug clinical trials:

Search ClinicalTrials for Influenza

Search NIH Clinical Center for Influenza

Search CenterWatch for Influenza

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Influenza

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Anatomical Context for Influenza

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Influenza:

32
T cells, Lung, Testes, Monocytes, Heart, Colon, B cells, Brain, Nk cells, Bone, Thyroid, Tonsil, Endothelial, Bone marrow, Kidney, Trachea, Spinal cord, Liver, Eye, Skin, Myeloid, Prostate

FMA organs/tissues related to Influenza:

14
Respiratory tract

Animal Models for Influenza or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Influenza:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.0PTPN11, SFTPD, IFNG, IFNB1, PDPN, NEU1
2MP:000538511.8PDPN, NEU1, IVNS1ABP, XYLB, CXCL10, PTPN11
3MP:000538711.7SFTPD, IFNG, IFNB1, PDPN, NEU1, XDH

Publications for Influenza

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Sources:
50PubMed
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Articles related to Influenza:

(show top 50)    (show all 3562)
idTitleAuthorsYear
1
Commuter mobility and the spread of infectious diseases: application to influenza in france. (24416152)
2014
2
Selection of DNA aptamers that bind to influenza A viruses with high affinity and broad subtype specificity. (24269231)
2014
3
Complete Genome Sequence of a Novel Reassortant H3N6 Avian Influenza Virus Isolated from Domestic Green-Winged Teal. (23682150)
2013
4
Current status and future needs in diagnostics and vaccines for high pathogenicity avian influenza. (23689886)
2013
5
Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination. (24404430)
2013
6
Descending thoracic aortitis due to Haemophilus influenzae: a case report and literature review. (23389816)
2013
7
Whole-genome analysis of influenza B viruses of multiple genotypes cocirculating in India. (24285663)
2013
8
Chitosan Nanoparticle Encapsulated Hemagglutinin-Split Influenza Virus Mucosal Vaccine. (24343789)
2013
9
A subunit vaccine candidate derived from a classic H5N1 avian influenza virus in China protects fowls and BALB/c mice from lethal challenge. (24055355)
2013
10
TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function. (22806096)
2013
11
Social network analysis used to assess the relationship between the spread of avian influenza and movement patterns of backyard chickens in Ratchaburi, Thailand. (23528640)
2013
12
Haemophilus influenza endophthalmitis after pterygium surgery. (21912259)
2013
13
Comparison of the reactogenicity of three different immunization schedules including diphtheria, tetanus, pertussis, Haemophilus influenza b and polio vaccine in Turkey. (23720155)
2013
14
Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza. (23341590)
2013
15
Accumulation and inactivation of avian influenza virus by the filter-feeding invertebrate Daphnia magna. (24038705)
2013
16
An epidemiologic simulation model of the spread and control of highly pathogenic avian influenza (H5N1) among commercial and backyard poultry flocks in South Carolina, United States. (23398856)
2013
17
Risk of confirmed Guillain-Barre syndrome following receipt of monovalent inactivated influenza A (H1N1) and seasonal influenza vaccines in the Vaccine Safety Datalink Project, 2009-2010. (22582210)
2012
18
Reactions of Norwegian children with severe egg allergy to an egg-containing influenza A (H1N1) vaccine: a retrospective audit. (22223837)
2012
19
Culture and PCR detection of Haemophilus influenzae and Haemophilus haemolyticus in Australian Indigenous children with bronchiectasis. (22553240)
2012
20
Alternative scan-based approaches to identify space-time clusters of highly pathogenic avian influenza virus H5N1 in wild birds in Denmark and Sweden in 2006. (23402133)
2012
21
Potential role of HPA axis and sympathetic nervous responses in depletion of B cells induced by H9N2 avian influenza virus infection. (23251416)
2012
22
Guillain-Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe. (21750072)
2011
23
ABCB1 polymorphisms and neuropsychiatric adverse events in oseltamivir-treated children during influenza H1N1/09 pandemia. (21902503)
2011
24
Purulent pericarditis caused by Haemophilus influenzae type B. (21562356)
2011
25
Noninvasive ventilation in acute respiratory failure due to H1N1 influenza. (21654986)
2011
26
Regulation of influenza A virus induced CXCL-10 gene expression requires PI3K/Akt pathway and IRF3 transcription factor. (21497908)
2011
27
Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. (20558397)
2010
28
Detection of E119V and E119I mutations in influenza A (H3N2) viruses isolated from an immunocompromised patient: challenges in diagnosis of oseltamivir resistance. (20194700)
2010
29
Randomized trial to assess immunogenicity and safety of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in infants. (20035207)
2010
30
Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States. (19597980)
2009
31
Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus. (19017984)
2008
32
Immunogenicity, reactogenicity and consistency of production of a Brazilian combined vaccine against diphtheria, tetanus, pertussis and Haemophilus influenzae type b. (19057823)
2008
33
Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection. (17372009)
2007
34
Mechanisms of symptoms of the common cold and influenza. (17370703)
2007
35
Neuraminidase inhibitors for preventing and treating influenza in healthy adults. (16855962)
2006
36
The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway. (16627618)
2006
37
A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy. (16517210)
2006
38
Origin of hemagglutinin and neuraminidase gene of swine influenza A H1N1 viruses]. (15340540)
2003
39
Comparison of the pathogenesis of two genetically different H3N2 influenza A viruses in pigs. (12734230)
2003
40
Two cases of severe bronchopneumonia due to influenza A (H3N2) virus: detection of influenza virus gene using reverse transcription polymerase chain reaction. (11201374)
2001
41
Successful treatment of post-influenza pseudomembranous necrotising bronchial aspergillosis with liposomal amphotericin, inhaled amphotericin B, gamma interferon and GM-CSF. (10525567)
1999
42
Membrane fusion promoted by increasing surface densities of the paramyxovirus F and HN proteins: comparison of fusion reactions mediated by simian virus 5 F, human parainfluenza virus type 3 F, and influenza virus HA. (9733810)
1998
43
Clinical features of patients with beta-lactamase producing Haemophilus influenzae isolated from sputum. (8961060)
1996
44
Photoaffinity labeling of influenza virus RNA polymerase PB1 subunit with 8-azido GTP. (7629040)
1995
45
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. (8145819)
1994
46
Mutational analysis of the influenza virus vRNA promoter. (8317146)
1993
47
Antigenic variant of swine influenza virus causing proliferative and necrotizing pneumonia in pigs. (1333815)
1992
48
Antibiotic susceptibility of invasive Haemophilus influenzae type b isolates in Denmark in 1988 and 1989. (1882199)
1991
49
Siderophore-independent acquisition of transferrin-bound iron by Haemophilus influenzae type b. (2143216)
1990
50
An epizootic of Swine influenza in ontario. (17422266)
1983

Genetic Variations for Influenza

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Expression for genes affiliated with Influenza

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Influenza

Search GEO for disease gene expression data for Influenza.

Pathways for genes affiliated with Influenza

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Influenza

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Influenza according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1cysteine4412.0SFTPD, IFNG, IFNB1, NEU1, XDH, PTPN11
2lipid4411.9SFTPD, IFNB1, XDH, CXCL10, MX1, PTPN11
3ifn-alpha4411.7IFNG, IFNB1, CXCL10, MX1, PTPN11
4rantes4411.7PTPN11, MX1, CXCL10, IFNB1, IFNG
5thymidine44 2412.6PTPN11, CXCL10, IFNB1, IFNG, SFTPD
6adenylate4411.5IFNB1, IVNS1ABP, CXCL10, FURIN, CPSF4
72,5-oligoadenylate4411.5IFNG, IFNB1, CXCL10, MX1
8poly(i-c)4411.5MX1, CXCL10, IFNB1, IFNG
9neopterin4411.5IFNG, IFNB1, CXCL10, MX1
10ribavirin44 49 1113.4MX1, NEU1, IFNG
11betaseron4411.4MX1, IFNB1, IFNG
12acyclovir44 1112.3IFNG, IFNB1, NEU1
13imiquimod44 28 59 1114.3MX1, IFNB1, IFNG
14con a4411.3IFNG, NEU1, FURIN
15fluticasone propionate44 49 59 1114.3CXCL10, IFNB1, IFNG
16gsno4411.3IFNG, XDH, CXCL10
17polyinosinic-polycytidylic acid4411.3CXCL10, IFNB1, IFNG
18il 104411.3IFNG, IFNB1, CXCL10
19polysaccharide4411.3SFTPD, IFNB1, PDPN, NEU1
20tarc4411.3CXCL10, IFNB1, IFNG
21ccl344 2812.3IFNG, IFNB1, CXCL10
22allergens4411.2CXCL10, IFNG, SFTPD
23cycloheximide4411.2MX1, CXCL10, IFNB1
24rebif4411.2MX1, IFNB1
25carboplatin44 49 1113.2IFNG, IFNB1, XDH
26tetracycline44 1112.1FURIN, PTPN11, IFNB1
27avonex4411.1MX1, IFNB1
28histamine44 28 2413.1SFTPD, IFNG, NEU1, CXCL10
29sodium stibogluconate44 1112.1IFNG, PTPN11
30mezerein4410.9IFNB1, IFNG
31kynurenine4410.9IFNB1, IFNG
32monosaccharide4410.8NEU1, SFTPD
33d penicillamine4410.7XDH, IFNG
34glatiramer acetate44 1111.5IFNB1, IFNG

GO Terms for genes affiliated with Influenza

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16Gene Ontology
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Biological processes related to Influenza according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922111.7IFNG, IFITM3, IFNB1, MX1, MX2, PTPN11
2type I interferon-mediated signaling pathwayGO:06033711.5PTPN11, MX2, MX1, IFNB1, IFITM3
3response to virusGO:00961511.5IFNG, IFITM3, IFNB1, IVNS1ABP, MX1
4defense response to virusGO:05160711.5IFNG, IFITM3, IFNB1, CXCL10, MX1
5negative regulation of viral genome replicationGO:04507111.1MX1, IFNB1, IFITM3
6positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.9IFNG, IFNB1
7negative regulation of viral transcriptionGO:03289710.9IFITM3, IFNB1
8negative regulation of viral entry into host cellGO:04659710.8IFNB1, IFITM3
9adaptive immune responseGO:00225010.8IFNB1, IFNG
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IFNG, FURIN
11regulation of interferon-gamma-mediated signaling pathwayGO:06033410.5PTPN11, IFNG

Products for genes affiliated with Influenza

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Influenza

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet