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Influenza malady
8 symptoms, 647 genes, 20 tissues, 798 related diseases, 25 phenotypes, 1133 articles, clinical trials.

Summaries for Influenza

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6Disease Ontology, 23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards
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MedlinePlus: Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. the main way to keep from getting the flu is to get a yearly flu vaccine. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. nih: national institute of allergy and infectious diseases23

MalaCards: Influenza, also known as flu, is related to carcinoma and leukemia, and has symptoms including chills, fever and sore throat. An important gene associated with Influenza is MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)), and among its related pathways are Cytokine-cytokine receptor interaction and Toll-like receptor signaling pathway. The compounds dexamethasone and arginine have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, whole blood and brain, and related mouse phenotypes are cellular and homeostasis/metabolism.

Disease Ontology: A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.6

CDC: Influenza A viruses are found in humans and many different animals, including ducks, chickens, pigs, whales, horses and seals.2

Wikipedia: Influenza, commonly known as the \'flu\' , is an infectious disease of birds and mammals caused by RNA...44 more...

Aliases & Descriptions for Influenza

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2CDC, 6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 23MedlinePlus, 24MeSH, 40SNOMED-CT, 27NCIt, 19ICD9CM
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Aliases & Descriptions:

influenza 6 8 32 43
flu 6 23
influenza with non-respiratory manifestation (disorder) 6
influenza with other manifestations nos (disorder) 6
influenza with other manifestations (disorder) 6
influenza with non-respiratory manifestation 6
influenza with other manifestations 6

Related Diseases for Influenza

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13GeneCards, 14GeneDecks
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Diseases related to influenza by text searches and GeneDecks gene sharing:

(show top 50)    (show all 795)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma70.0PIGR, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
2leukemia68.4PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
3arthritis60.2PIK3CD, PIK3CG, RECK, RELA, KIR2DL1, KIR2DL2
4melanoma57.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5prostatitis56.4PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
6neuronitis55.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
7haemophilus influenzae54.9PIK3CG, VTN, NAPSA, VDAC1, CMAS, CLEC7A
8pneumonia53.7PIGR, PIK3C2A, RELA, VTN, SFTPA1, SFTPD
9pancreatitis52.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
10viral infectious disease51.4ZNF17, PIK3CG, NCL, NCR1, NCR2, RECK
11cervicitis50.2PIK3CA, PIK3CG, NCL, NCR1, NCR2, RECK
12adenocarcinoma50.1PIGR, PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
13fibrosis48.9PIK3CA, PIK3CG, RECK, RELA, VTN, SFTPA1
14alzheimer's disease48.6PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCL
15colorectal cancer48.6PIGS, PIGR, PIK3CB, PIK3CD, PIK3CA, PIK3R3
16herpes simplex47.7PIK3CA, PIK3CG, NCL, NCR1, NCR2, RECK
17myeloid leukemia45.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
18colon cancer44.9PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, RECK
19retinitis44.4PIK3CA, PIK3C2A, PIK3CG, VTN, SERPINE1, RAB6A
20atherosclerosis43.8PIK3C2A, PIK3CG, RECK, VTN, PCSK5, SELL
21immunodeficiency43.5PIK3CD, SELL, MYD88, BLZF1, CLEC4M, LGALS1
22cystic fibrosis43.0PIK3CG, RECK, SFTPA1, SFTPD, SELL, NAGA
23measles42.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
24avian influenza42.8SFTPD, PCSK5, PCSK6, SERPINE1, SCRIB, CHAC1
25pulmonary disease42.3PIK3CG, SFTPA1, SFTPD, SELL, SERPINE1, LITAF
26sepsis40.2RECK, VTN, SFTPD, SELL, SERPINE1, VDAC1
27nasopharyngitis40.1PIGR, PIK3CA, PIK3CG, RECK, RELA, KIR2DL1
28sarcoidosis39.5PIK3C2A, VTN, SFTPD, SELL, LBR, B2M
29meningitis39.5PIK3C2A, PIK3CG, SELL, VDAC1, MYD88, CMAS
30acute myeloid leukemia39.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
31vaccinia38.7PIK3CG, NCR1, NCR2, RELA, PCSK5, PCSK6
32encephalitis38.6PIK3CG, MYD88, RAF1, SCRIB, CIITA, MX1
33lymphoblastic leukemia38.4PIK3CA, PIK3CG, RECK, RELA, SFTPD, SELL
34stomatitis38.2PIK3CG, VPS4A, VPS4B, BLZF1, SCG5, MX1
35blindness38.0PIK3C2A, PIK3CG, SERPINE1, RARA, LCN2, LACTB
36pertussis38.0PIK3CG, RELA, SFTPA1, SELL, VDAC1, MYD88
37peritonitis37.2PIK3C2A, NCR1, NCR2, RELA, KIR2DL1, VTN
38bronchiolitis37.0PIK3C2A, SFTPA1, SFTPD, SELL, MUC2, MUC5AC
39chagas disease36.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
40otitis media35.6SFTPA1, SELL, SERPINE1, MYD88, MUC2, MUC5AC
41copd35.0PIK3C2A, RELA, SFTPD, SELL, SERPINE1, RARA
42bronchial asthma34.5SFTPD, SELL, MUC5AC, XDH, CFTR, MPO
43myelodysplastic syndrome34.1PIK3CG, NCL, SELL, RARA, BAX, LBR
44hepatitis34.0XDH, ASGR2, GZMB, IL2RB, FASLG, FAS
45coronary heart disease34.0PIK3C2A, SELL, SERPINE1, LPXN, MYD88, LIPE
46hepatitis c33.8CIITA, MX1, LDLR, JUN, JAK1, CD28
47asthma33.6SERPINE1, MPO, IL12B, IL1B, IL4, CCL2
48encephalomyelitis33.4CIITA, CFH, MPO, CD86, CD40LG, CD80
49tonsillitis33.4LILRB1, LACTB, LAIR1, CD79A, CD27, CD69
50chronic obstructive pulmonary disease33.2SFTPD, MUC2, MUC5AC, LACTB, XDH, CFTR

Graphical network of the top 20 diseases related to influenza:



Graphical network of diseases related to influenza

Clinical Features for Influenza

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6Disease Ontology
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Symptoms: chills, fever, sore throat, runny nose, muscle pains, severe headache, cough, weakness.6

Drugs & Therapeutics for Influenza

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Influenza

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Anatomical Context for Influenza

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11FMA, 22MalaCards
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MalaCards organs/tissues related to influenza:

22
Whole blood, Brain, Small intestine, Colon, Kidney, Liver, Lung, Prostate, Tonsil, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Bronchial epithelium

FMA organs/tissues related to influenza:

11
Respiratory tract

Phenotypes for genes affiliated with Influenza

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25MGI
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MGI Mouse Phenotypes related to influenza:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cellular phenotypeMP:000538424.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
2homeostasis/metabolism phenotypeMP:000537623.3PIGR, PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1
3mortality/agingMP:001076823.2PIK3CB, PIK3CA, PIK3C2A, NCR1, RECK, RELA
4hematopoietic system phenotypeMP:000539719.4PIGR, NCR1, SGPL1, BST2, MYD88, LITAF
5immune system phenotypeMP:000538719.3PIGR, PIK3CD, PIK3R5, SGPL1, PCSK5, SELL
6growth/size phenotypeMP:000537818.2PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, RECK
7normal phenotypeMP:000287317.6PIK3R1, NCR1, RELA, VTN, GCM1, RARA
8cardiovascular system phenotypeMP:000538517.4PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
9nervous system phenotypeMP:000363116.6RECK, RELA, PCSK5, PCSK6, GCM1, NAV2
10tumorigenesisMP:000200616.2PIK3CB, PIK3CA, PIK3R2, PIK3R1, BTG3, SELL
11behavior/neurological phenotypeMP:000538615.7PIK3CA, NAV2, VDAC1, MYD88, MYO6, LIPE
12integument phenotypeMP:001077115.4PIK3CG, RECK, RELA, NAV2, RAF1, RAE1
13no phenotypic analysisMP:000301215.3PIK3CD, PIK3R1, PCSK5, BST2, MYD88, CLEC4A
14reproductive system phenotypeMP:000538915.0PIGR, PIK3CA, SGPL1, MYO6, RARA, LIPE
15skeleton phenotypeMP:000539014.9PIK3CD, PIK3CG, RECK, RELA, SGPL1, PCSK5
16renal/urinary system phenotypeMP:000536714.8SGPL1, PCSK5, MYD88, RARA, UMOD, BAX
17digestive/alimentary phenotypeMP:000538114.6PIGR, SGPL1, PCSK5, PCSK6, RARA, LIPE
18muscle phenotypeMP:000536914.1PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA, SGPL1
19vision/eye phenotypeMP:000539113.8PIK3CA, RELA, PCSK6, NAV2, MYD88, MYO6
20liver/biliary system phenotypeMP:000537013.6RECK, LIPE, SCG5, LBP, CFTR, ATF2
21endocrine/exocrine gland phenotypeMP:000537913.1SGPL1, SELL, SCG5, SCRIB, LDLR, XDH
22respiratory system phenotypeMP:000538812.9SGPL1, SFTPD, PCSK5, PCSK6, SELL, CLEC7A
23embryogenesis phenotypeMP:000538012.3PIK3CB, PIK3CA, RECK, PCSK6, RAF1, RAE1
24adipose tissue phenotypeMP:000537511.1PIK3CA, PIK3R1, PIK3C2A, SERPINE1, MYD88, RAE1
25other phenotypeMP:000539510.8RECK, RARA, LDLR, JAK2, CD40LG, FN1

Publications for genes affiliated with Influenza

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35PubMed
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Articles related to influenza:

(show top 50)    (show all 1133)
idTitleAuthorsYearAffiliating Genes
1Induction of cell surface human leukocyte antigen-G e xpression in pandemic H1N1 2009 and seasonal H1N1 influenza virus-infected pati ents. (21087648)Chen H.X.... Yan W.H.2011HLA-G
2Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin. (21621240)Watanabe R.... Lamb R.A.2011BST2
3Inhibition of MLC phosphorylation restricts replicati on of influenza virus--a mechanism of action for anti-influenza agents. (21731751)Haidari M.... Chen Z.2011MYL1
4A mouse model of lethal synergism between influenza v irus and Haemophilus influenzae. (20042666)Lee L.N.... Sarawar S.R.2010CXCR3
5Permissive secondary mutations enable the evolution o f influenza oseltamivir resistance. (20522774)Bloom J.D.... Baltimore D.2010NEU1
6Influenza A virus polymerase inhibits type I interfer on induction by binding to interferon beta promoter stimulator 1. (20699220)Iwai A.... Miyazaki T.2010IFNB1, MAVS
7A novel type of influenza vaccine: safety and immunog enicity of replication-deficient influenza virus created by deletion of the int erferon antagonist NS1. (20039806)Wacheck V.... Muster T.2010IVNS1ABP
8Phenotypic and molecular characterization of beta-lac tam resistance and capsular typing of colonizing Haemophilus influenzae strains isolated from neutropenic patients in Tunisia. (18178031)Touati A.... Ben Hassen A.2009PKD1, LACTB
9CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. (19007960)Hale B.G.... Randall R.E.2009PTPN11
10Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. (19155475)Wang J.... Mason R.J.2009TNF, IL6, IL8
11Clinical effectiveness of oseltamivir and zanamivir f or treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japan ese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons. (19911968)Kawai N.... Kashiwagi S.2009NEU1
12HLA class I molecules consistently present internal influenza epitopes. (19122146)Wahl A.... Hildebrand W.H.2009HLA-B
13Oseltamivir susceptibility in south-western France du ring the 2007-8 and 2008-9 influenza epidemics and the ongoing influenza pandem ic 2009. (19814958)Burrel S.... Fleury H.2009NEU1
14Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza. (19736294)Xie D.... Zhang J.2009GZMB
15A prospective, comparative study of the immune response to inactivated influenza vaccine in pediatric liver transplant recipients and their healthy siblings. (18230041)Madan R.P.... Herold B.C.2008IFNG
16Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines. (18713944)Yu C.I.... Palucka A.K.2008IFNG
17Heterosubtypic T-cell responses against avian influenza H5 haemagglutinin are frequently detected in individuals vaccinated against or previously infected with human subtypes of influenza. (19453462)Goy K.... Ffrench R.2008IFNG
18Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. (16959331)Hammerbeck D.M.... Miller R.L.2007TLR8, IFNA1
19Performance of six influenza rapid tests in detecting human influenza in clinical specimens. (17452000)Hurt A.C.... Barr I.G.2007HLA-B
20Mx1 gene protects mice against the highly lethal human H5N1 influenza virus. (17700072)Salomon R.... Hoffmann E.2007MX1
21The C terminus of the nucleoprotein of influenza A virus delivers antigens transduced by Tat to the trans-golgi network and promotes an efficient presentation through HLA class I. (16306624)Bettosini F.... Sorrentino R.2005TAT
22Apoptosis under hypercytokinemia is a possible pathogenesis in influenza-associated encephalopathy. (15771696)Nunoi H.... Endo F.2005TNF, IL8
23Zanamivir: an influenza virus neuraminidase inhibitor. (15918777)Colman P.M.2005NEU1
24Sensitivity of various influenza virus strains to ar bidol. Influence of arbidol combination with different antiviral drugs on repro duction of influenza virus A (16206613)Leneva I.A.... Glushkov R.G.2005NEU1
25Sialobiology of influenza: molecular mechanism of hos t range variation of influenza viruses. (15744059)Suzuki Y.2005F2RL1
26Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. (15494906)Nichols W.G.... Boeckh M.2004NEU1
27Cytokine induction in human cord blood lymphocytes after pulsing with UV-inactivated influenza viruses. (15275967)Divanovic S.... Lai A.C.2004IFNG
28Avian influenza: a new pandemic threat? (15065617)Trampuz A.... Baddour L.M.2004NEU1
29Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. (14752052)Turan K.... Nagata K.2004MX1
30Influenza viruses and atherosclerosis: the role of atherosclerotic plaques in prolonging the persistent form of influenza infection (12741353)Pleskov V.M.... Pleskova I.u.V.2003LPXN
31T-cell responses and hypersensitivity to influenza and egg antigens among adults with asthma immunized with the influenza vaccine. (13679822)Miller R.L.... Rothman P.B.2003IFNG
32Drug under test: influenza--Relenza in daily practice . Experience during the influenza season 1999/2000. (12458355)Schmidt R.E.2002NEU1
33Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. (12149435)Geiss G.K.... Garcia-Sastre A.2002PTPN11, IFNA1
34Management of influenza in patients with asthma or ch ronic obstructive pulmonary disease. (11770690)Nathan R.A.... Woodhead M.2001NEU1
35Aromatic sialic acid analogues as potential inhibitor s of influenza virus neuraminidase. (11421259)Bianco A.... Melchioni C.2001NEU1
36Influenza vaccine, anti-influenza drugs, and rapid diagnosis in Japan. (11810539)Sugaya N.2000NEU1
37The anti-influenza virus agent 4-GU-DANA (zanamivir) inhibits cell fusion mediated by human parainfluenza virus and influenza virus HA. (11070006)Greengard O.... Moscona A.2000NEU1, ZNF17
38Safety and efficacy of once daily intranasal zanamivi r in preventing experimental human influenza A infection. (12731753)Calfee D.P.... Hayden F.G.1999NEU1
39Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. (10205180)Chen Z.... Krug R.M.1999PABPN1
40Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. (16526129)Kim C.U.... Stevens R.C.1997NEU1
41Large outbreak of swine influenza in southern Japan caused by reassortant (H1N2) influenza viruses: its epizootic background and characterization of the causative viruses. (8760422)Ouchi A.... Inaba Y.1996NEU1
42Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import. (7559393)O'Neill R.E.... Moroianu J.1995KPNB1, KPNA1
43Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent. (8039508)Baudin F.... Ruigrok R.W.1994RNPC3
44Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex. (1381757)Tulip W.R.... Colman P.M.1992NEU1
45A long-lived state for influenza virus-erythrocyte complexes committed to fusion at neutral pH. (1397318)Schoch C.... Clague M.J.1992NEU1
46Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. (1985200)Mukaigawa J.... Nayak D.P.1991KPNB1, KPNA1
47Virucidal activity and viral protein modification by myeloperoxidase: a candidate for defense factor of human polymorphonuclear leuk ocytes against influenza virus infection. (1647427)Yamamoto K.... Suzuki K.1991MPO
48Tumor necrosis factor-alpha production of influenza A virus-infected macrophages and potentiating effect of lipopolysaccharides. (2391423)Nain M.... Gemsa D.1990TNF
49Evolution of the NS genes of the influenza A viruses. II. Characteristics of the amino acid changes in the NS1 proteins of the influenza A viruses. (2144065)Nakajima K.... Nakajima S.1990PTPN11
50Enhancement of anti-influenza A virus cytotoxicity fo llowing influenza A virus vaccination in older, chronically ill adults. (2123886)Gorse G.J.... Belshe R.B.1990IFNG

Expression for genes affiliated with Influenza

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Influenza

Pathways for genes affiliated with Influenza

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20KEGG, 36QIAGEN, 41Thomson Reuters, 10EMD Millipore, 37R&D Systems
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Pathways related to influenza according to GeneDecks:

(show top 50)    (show all 472)
idPathwayScoreTop Affiliating Genes
1Cytokine-cytokine receptor interaction2016.7CD27, CD70, CD40LG, CD40, IL10, IL10RA
2Toll-like receptor signaling pathway2016.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
3Tuberculosis2015.9RELA, MYD88, RAF1, CLEC4M, CLEC7A, CIITA
4RIG-I-like receptor signaling pathway2014.4RELA, ISG15, IRF3, IRF7, IL12A, IL12B
5Jak-STAT signaling pathway2014.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
6PAK Pathway3614.1PIK3R3, PIK3R2, PIK3R1, MYO6, PAK1, BAX
7Phagosome2014.1SFTPA1, SFTPD, CLEC4M, CLEC7A, LAMP1, ATP6V0E2
8PEDF Induced Signaling3613.7RELA, RAF1, BAX, CD80, IL10, IL11
9Toxoplasmosis2013.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
10Regulation of eIF4 and p70S6K3613.4PIK3R3, PIK3R2, PIK3R1, PABPC1, BAX, CD4
11NFAT in Immune Response3612.8PIK3R3, PIK3R2, PIK3R1, XPO1, ATF2, JUN
12Staphylococcus aureus infection2012.3CFH, ITGAL, FCGR1A, IL10, MBL2, ICAM1
13Viral myocarditis2012.3CD28, CD86, CD40LG, CD80, CD40, ITGAL
14Immune response_IL-22 signaling pathway4112.2JUN, JAK1, JAK2, CD28, CD86, CD4
15SUMO Pathway3612.2RANBP2, UBE2I, IL1A, IL1B, MAPK8, MAP2K6
16Immune response IL-22 signaling pathway1012.1JUN, JAK1, JAK2, CD28, CD86, CD4
17Bacterial infections in CF airways4112.1RELA, SFTPA1, SFTPD, MYD88, LBP, CFTR
18Colorectal Cancer Metastasis3612.1PIK3R3, PIK3R2, PIK3R1, BAX, JAK1, GSK3B
19CTL Mediated Apoptosis3611.9CD3D, GZMB, CASP8, CASP9, HLA-A, HLA-B
20Allograft rejection2011.9CD28, CD86, CD40LG, CD80, CD40, GZMB
21Immune response_MIF in innate immunity response4111.9RELA, MYD88, LBP, JUN, IRAK4, MIF
22Immune response NFAT in immune response1011.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
23African trypanosomiasis2011.8MYD88, IL10, IL12A, IL12B, IL18, IL1B
24IL-4 Pathway3611.7PIK3R3, PIK3R2, PIK3R1, RAF1, JAK1, GSK3B
25FLT3 Signaling3611.6PIK3R3, PIK3R2, PIK3R1, RAF1, MAP2K6, MAP2K2
26Intestinal immune network for IgA production2011.6PIGR, CD28, CD86, CD40LG, CD80, CD40
27Immune response_T cell receptor signaling pathway4111.5RELA, RAF1, UBC, CD3D, CD4, MAP2K2
28NFAT and Cardiac Hypertrophy3611.4PIK3R3, PIK3R2, PIK3R1, RAF1, GSK3B, IL11
29Immune response IFN gamma signaling pathway1011.4PIK3R3, ATF2, JAK2, MAP2K6, MAPK12, MAPK13
30Development_Endothelin-1/EDNRA signaling4111.4MAPK14, MAPK10, HRAS, SRC
31UVA-Induced MAPK Signaling3611.3PIK3R3, PIK3R2, PIK3R1, JUN, MAPK8, MAPK12
32Development FGFR signaling pathway1011.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
33Development Glucocorticoid receptor signaling1011.2RELA, SERPINE1, UBE2I, JUN, FKBP4, HSPA2
34Immune response Antigen presentation by MHC class II1011.2CD3D, CD4, CD74, IFI30, HLA-DMA, HLA-DMB
35Transcription_PPAR Pathway4111.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
36Development_FGFR signaling pathway4111.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
37CNTF Signaling3611.0PIK3R3, PIK3R2, PIK3R1, RAF1, JAK1, JAK2
38Development Prolactin receptor signaling1010.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
39Development_Prolactin receptor signaling4110.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
40Development_VEGF-family signaling4110.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
41IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types3710.9CD3D, GZMB, IL15, IL15RA, IL2, IL2RA
42IL-3 Pathway3610.9PIK3R3, PIK3R2, PIK3R1, RAF1, JUN, JAK2
43Development VEGF signaling and activation1010.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
44Amoebiasis2010.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
45Immune response IL-4 signaling pathway1010.8PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, RELA
46Development_IGF-1 receptor signaling4110.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
47Development_EGFR signaling pathway4110.6PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
48Development IGF-RI signaling1010.6PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R1, RELA
49Non-small cell lung cancer2010.6PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
50Apoptosis and survival_Role of CDK5 in neuronal death and survival4110.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1

Compounds for genes affiliated with Influenza

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Sources:
32Novoseek , 42Tocris Bioscience, 34PharmGKB, 9DrugBank, 18HMDB
See all sources

Compounds related to influenza according to GeneDecks:

(show top 50)    (show all 413)
idCompoundScoreTop Affiliating Genes
1dexamethasone32 42 34 9 9 23.9PIK3CA, PIK3R1, VTN, SFTPD, SELL, SERPINE1
2arginine32 18.1PIK3CA, PIK3C2A, NCL, RECK, VTN, PCSK6
3cyclosporin a32 42 18.0PIK3CA, PIK3C2A, PIK3CG, RECK, VDAC1, RAF1
4steroid32 16.6PIK3CB, PIK3CA, PIK3R1, PIK3C2A, SFTPD, VDAC1
5h2o232 16.1PIK3CB, PIK3R1, PIK3CG, SELL, VDAC1, BLZF1
6hydrogen32 18 16.7RARA, SCG5, CIITA, ATP6V0E2, CD40, ITGAL
7heparin32 9 18 9 18.5PIK3CA, PIK3C2A, PIK3CG, NCL, RECK, VTN
8genistein32 9 18 9 18.5PIK3CA, PIK3R1, PIK3CG, SELL, SERPINE1, RAF1
9histamine32 18 16.1PIK3CA, SFTPD, SELL, RAF1, SCG5, MUC5AC
10doxorubicin32 34 9 9 17.6PIK3CA, PIK3C2A, PIK3CG, RECK, RAF1, B2M
11carbohydrates32 14.4RECK, SFTPD, SELL, NAGA, BLZF1, CLEC4A
12vegf32 14.4PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, RECK
13wortmannin32 42 15.4PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
14estrogen32 14.2PIK3CB, PIK3R1, NCL, SERPINE1, RARA, RAF1
15ethanol32 34 9 18 9 18.0LIPE, MUC5AC, LBR, CES1, ITGAL, ASGR2
16tacrolimus32 34 9 9 16.9PIK3CA, VTN, SERPINE1, RAF1, CFH, CD28
17butyrate32 13.9RARA, RAF1, BLZF1, SCG5, LGALS1, MUC2
18cisplatin32 34 9 9 16.8PIK3CA, PIK3C2A, VTN, VDAC1, RAF1, BLZF1
19ifn-alpha32 13.7MX1, JAK1, IRF1, IRF3, IRF7, IRF9
20ly29400232 13.5PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, VTN
21cyclic amp32 18 14.5PIK3R1, SFTPD, LIPE, LGALS4, CIITA, LBR
22lysine32 13.4NCL, RECK, RELA, VDAC1, LDLR, UBE2I
23endotoxin32 13.4RECK, SFTPD, SELL, MYD88, CIITA, LBP
24sialic acid32 13.4ZNF17, RECK, SELL, CMAS, CLEC4A, LGALS1
25polyinosinic-polycytidylic acid32 13.1CIITA, CD40, IRF1, IRF3, IRF7, IL10
26mg 13232 42 13.8PIK3CG, RARA, BLZF1, BAX, CFTR, JUN
27paclitaxel32 34 9 9 15.8PIK3CA, PIK3CG, NCL, RARA, RAF1, BAX
28neopterin32 12.7MX1, LCN2, LBR, B2M, CD79A, CD4
29forskolin32 42 9 9 15.7PIK3R1, GCM1, RAF1, LIPE, BLZF1, MUC2
30ascorbic acid32 18 13.6PIK3CG, RAF1, LDLR, CFTR, JAK2, CD40LG
31prednisolone32 9 9 14.5PIK3C2A, SFTPD, SELL, LCN2, MPO, CD79A
32norepinephrine32 9 18 9 15.5PIK3C2A, SELL, LIPE, LBR, CFTR, CD79A
33acetylcholine32 9 18 9 15.3PIK3C2A, RAF1, BLZF1, PAK1, LDLR, LBR
34thyroxine32 18 13.2PIK3C2A, CIITA, LDLR, B2M, CD79A, CD40LG
35quercetin32 42 9 18 9 16.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
36phosphatidylcholine32 12.1PIK3CB, SFTPD, VDAC1, RAF1, LIPE, LDLR
37lactacystin32 12.1PIK3CG, RAF1, JUN, JAK2, CD69, CD4
38n acetylcysteine32 12.1RAF1, MUC5AC, CFTR, JAK1, JAK2, CD79A
39mdms32 12.1CIITA, CD4, CD9, IRF3, IL10, CCL4
40anisomycin32 42 9 9 14.9PIK3CG, RAF1, LDLR, ATF2, JUN, IL1B
41vincristine32 34 9 9 14.9RECK, ANXA5, MAP2K4, MAPK3, IFNA1, IFNB1
42ag 147832 11.8PIK3CA, PIK3CG, SERPINE1, RAF1, MUC5AC, JUN
434-hydroxynonenal32 18 12.7BAX, XDH, ATF2, MPO, JUN, IL10
44triptolide32 11.7BAX, JUN, CD86, CD40, IL1B, IL2
45etoposide32 42 9 9 14.6PIK3CB, PIK3CA, PIK3R1, PIK3CG, RECK, RARA
46fluticasone propionate32 42 9 9 14.3MPO, IL16, IL1B, IL4, IL5, IL8
47theophylline32 9 18 9 14.2SELL, RAF1, XDH, B2M, CD79A, CD40LG
48sulindac32 9 9 13.1BAX, MAPK3, IKBKB, ALB, CASP8, CASP9
49gm-csf32 11.1IL10, IL11, IL15, IL18, IL1A, IL1B
50adriamycin32 11.0BAX, B2M, FN1, IRF1, IL3, FASLG

GO Terms for genes affiliated with Influenza

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Sources:
12Gene Ontology
See all sources

Cellular components related to influenza according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573722.1PIK3R5, PIK3C2A, PIK3CG, RELA, VPS28, VPS4A
2plasma membraneGO:00588621.7PIK3CD, PIK3R1, PIK3C2A, PIK3CG, RECK, KIR2DL1
3extracellular regionGO:00557620.7PIGR, VTN, SFTPA1, SFTPD, SERPINE1, CLEC4M
4cytosolGO:00582919.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5extracellular spaceGO:00561518.5VTN, SFTPA1, SFTPD, PCSK5, PCSK6, SERPINE1
6integral to plasma membraneGO:00588716.6PIGR, NCR1, NCR2, KIR2DL1, SELL, BST2
7external side of plasma membraneGO:00989714.6SELL, LILRB1, CLEC7A, LDLR, LAMP1, B2M
8nucleoplasmGO:00565414.4RELA, MYO6, RARA, PABPN1, CIITA, UBC
9endosome membraneGO:01000813.1VPS28, VPS4B, MYD88, LDLR, UBC, LAMP1
10lysosomeGO:00576412.7SFTPD, VPS4B, NAGA, NAPSA, LDLR, LAMP1
11cell surfaceGO:00998612.4PCSK6, BST2, RARA, LGALS1, LDLR, FURIN
12lysosomal membraneGO:00576512.0LITAF, LAMP1, LAMP3, CD74, ITM2C, IFITM3
13integral to lumenal side of endoplasmic reticulum membraneGO:07155611.6CD74, CANX, CALR, HLA-A, HLA-B, HLA-DPA1
14MHC class II protein complexGO:04261311.4CD74, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1
15clathrin-coated endocytic vesicle membraneGO:03066911.2LDLR, CD74, FCGR1A, HLA-DPA1, HLA-DPB1, HLA-DQA1
16ER to Golgi transport vesicle membraneGO:01250711.2B2M, CD74, HLA-A, HLA-B, HLA-DPA1, HLA-DPB1
17transport vesicle membraneGO:03065810.8CD74, CA4, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2
18endocytic vesicle membraneGO:03066610.7UBC, CD74, CAMK2B, HLA-DPA1, HLA-DPB1, HLA-DQA1

Biological processes related to influenza according to GeneDecks:

(show top 50)    (show all 74)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508719.6PIK3CD, PIK3CG, RELA, SFTPD, BST2, MYD88
2response to virusGO:00961517.4BST2, MYD88, LILRB1, MX1, MX2, IVNS1ABP
3cytokine-mediated signaling pathwayGO:01922117.2RELA, MYD88, RANBP2, RAE1, CIITA, MX1
4signal transductionGO:00716517.0PIK3CB, PIK3CD, NCR1, NCR2, BST2, LPXN
5virus-host interactionGO:01904816.1PIK3R1, RELA, VDAC1, CLEC4M, PABPN1, SCRIB
6immune responseGO:00695516.1KIR2DL1, VTN, CIITA, MR1, CD70, CD86
7inflammatory responseGO:00695415.4PIK3CD, PIK3CG, RELA, MYD88, CLEC7A, CD40LG
8type I interferon-mediated signaling pathwayGO:06033715.0MX1, MX2, JAK1, ISG15, ISG20, IRF1
9cell-cell signalingGO:00726714.1PCSK5, BST2, CD70, CD86, CD80, ISG15
10cell surface receptor signaling pathwayGO:00716613.9MYD88, CLEC4A, CD28, CD27, CD3D, CD4
11apoptotic processGO:00691513.8SGPL1, VDAC1, RAF1, LITAF, PAK1, LGALS1
12defense response to virusGO:05160713.6RELA, BST2, LILRB1, CD86, CD40, ITGAX
13positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312313.4RELA, BST2, MYD88, LITAF, LGALS1, UBC
14interferon-gamma-mediated signaling pathwayGO:06033313.3CIITA, B2M, JAK1, JAK2, IRF1, IRF3
15chemotaxisGO:00693512.9PIK3CB, IL4, MAPK14, MAPK1, MAP2K1, CCL4
16blood coagulationGO:00759612.8PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
17Toll signaling pathwayGO:00806312.7RELA, MYD88, UBC, LBP, ATF2, JUN
18regulation of type I interferon-mediated signaling pathwayGO:06033812.7JAK1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17
19toll-like receptor 4 signaling pathwayGO:03414212.6RELA, MYD88, UBC, ATF2, JUN, IRAK4
20negative regulation of viral genome replicationGO:04507112.4BST2, MX1, APOBEC3F, APOBEC3G, MAVS, CCL5
21positive regulation of interleukin-6 productionGO:03275512.4MYD88, LBP, IL1A, IL1B, IL33, IL6
22toll-like receptor signaling pathwayGO:00222412.3RELA, MYD88, UBC, ATF2, JUN, CD86
23positive regulation of tumor necrosis factor productionGO:03276012.2MYD88, CLEC7A, LBP, JAK2, IL12B, IL18
24defense response to bacteriumGO:04274212.2IL10, MAVS, CCL20, IFNB1, IFNG, TNFRSF1A
25positive regulation of NF-kappaB transcription factor activityGO:05109212.2RELA, MYD88, UBC, CD40, IL1B, IL6
26toll-like receptor 3 signaling pathwayGO:03413812.1RELA, UBC, ATF2, JUN, IRF3, IRF7
27T cell costimulationGO:03129512.1PIK3CA, PIK3R3, PIK3R2, PIK3R1, PAK1, CD28
28TRIF-dependent toll-like receptor signaling pathwayGO:03566612.1RELA, UBC, ATF2, JUN, IRF3, IRF7
29cellular response to mechanical stimulusGO:07126012.0MYD88, CD40, IRF1, IL18, IL1B, FAS
30MyD88-dependent toll-like receptor signaling pathwayGO:00275512.0RELA, MYD88, UBC, ATF2, JUN, IRAK4
31negative regulation of type I interferon productionGO:03248011.9UBA7, UBC, ISG15, IRF3, MAVS, IKBKE
32MyD88-independent toll-like receptor signaling pathwayGO:00275611.9RELA, UBC, ATF2, JUN, IRF3, IRF7
33nerve growth factor receptor signaling pathwayGO:04801111.9PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, PCSK5
34toll-like receptor 1 signaling pathwayGO:03413011.9RELA, MYD88, UBC, ATF2, JUN, IRAK4
35toll-like receptor 2 signaling pathwayGO:03413411.9RELA, MYD88, UBC, ATF2, JUN, IRAK4
36lipopolysaccharide-mediated signaling pathwayGO:03166311.8MYD88, LBP, IRF3, IL18, IL1B, MAPK3
37response to lipopolysaccharideGO:03249611.7LBP, JUN, JAK2, IL12A, IL1A, FASLG
38positive regulation of apoptotic processGO:04306511.6LILRB1, SCRIB, BAX, JAK2, IL1B, FASLG
39activation of MAPK activityGO:00018711.5PIK3CB, UBC, CD74, ITGA1, IL1B, MAP2K6
40positive regulation of interleukin-12 productionGO:03273511.3CD40LG, CD40, IL12B, CCR7, CCL19, IFNG
41MAPK cascadeGO:00016511.3RAF1, PAK1, IL18, IL1B, MAP2K2, MAPK12
42anti-apoptosisGO:00691611.3PIK3CA, RELA, MYD88, UBC, MPO, CD27
43positive regulation of nitric oxide biosynthetic processGO:04542911.3JAK2, IL1B, IFNG, ICAM1, HSP90AA1, HRH1
44response to hypoxiaGO:00166611.3RAF1, PAK1, ATP1B1, IL18, IL1A, IL1B
45T cell receptor signaling pathwayGO:05085211.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
46stress-activated MAPK cascadeGO:05140311.1UBC, ATF2, JUN, MAPK8, MAP2K6, MAP2K2
47positive regulation of inflammatory responseGO:05072910.9SERPINE1, JAK2, IL12B, IL15, IL18, IL2
48platelet activationGO:03016810.8PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
49cellular response to lipopolysaccharideGO:07122210.2SERPINE1, LILRB1, PAF1, LBP, CDC73, IL10
50positive regulation of transcription from RNA polymerase II promoterGO:04594410.1RELA, SERPINE1, MYD88, MYO6, RARA, LILRB1

Molecular functions related to influenza according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551525.5NXF1, SLIT2, CPSF1, CPSF3, RUVBL2, RTF1
2ATP bindingGO:00552414.4PIK3CB, CFTR, ATP8A2, JAK1, JAK2, CDK9
3cytokine activityGO:00512513.9IL12A, IL12B, IL15, IL16, IL18, IL1A
4receptor activityGO:00487212.7TNFRSF10B, TNFRSF9, KLRG1, TLR1, TLR2, TLR3
5chemokine activityGO:00800912.3CCL19, CCL5, CXCL10, CXCL11, CXCL13, CXCL3
6serine-type endopeptidase activityGO:00425212.0TMPRSS11D, PLAT, PLG, LTF, KLK11, ELANE
7double-stranded RNA bindingGO:00372512.0TLR7, TLR8, DHX9, STAU1, SON, ADAR
8MHC class II receptor activityGO:03239511.0HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2
9protein serine/threonine kinase activityGO:00467410.8AKT3, AKT2, AKT1, IKBKB, MAP2K1, MAP2K7
10protein kinase activityGO:00467210.8IKBKE, AKT1, AKT3, TBK1, SRC, RPS6KA3
11protease bindingGO:00202010.2HSPA1B, TP53, TNF, TNFAIP3, TNFRSF1A, ELANE

Sources for Influenza

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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