MCID: INF038
MIFTS: 67

Influenza malady

Genetic diseases (common), Respiratory diseases categories

Aliases & Classifications for Influenza

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Influenza, Aliases & Descriptions:

Name: Influenza 9 11 43 3 60
Flu 9 32 3
Influenza with Non-Respiratory Manifestation 9 60
 
Influenza with Other Manifestations Nos 9
Influenza with Other Manifestations 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:8469
NCIt38 C53482
MeSH33 D007251
ICD9CM27 487

Summaries for Influenza

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MedlinePlus:32 Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. most people with the flu recover on their own without medical care. people with mild cases of the flu should stay home and avoid contact with others, except to get medical care. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. the main way to keep from getting the flu is to get a yearly flu vaccine. good hygiene, including hand washing, can also help. nih: national institute of allergy and infectious diseases

MalaCards based summary: Influenza, also known as flu, is related to pneumonia and hepatitis, and has symptoms including chills, fever and sore throat. An important gene associated with Influenza is IFITM3 (interferon induced transmembrane protein 3), and among its related pathways are Immune response Bacterial infections in normal airways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drug influenza neuraminidase inhibitor [epc] and the compounds rebif and avonex have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, brain and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:9 A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

CDC:3 There are many different influenza A viruses; some are found in humans and others in animals such as avian flu in birds and poultry.

Wikipedia:63 Influenza, commonly known as \"the flu\", is an infectious disease caused by the influenza virus.... more...

Related Diseases for Influenza

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Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 426)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7XDH, SFTPD, NEU1, CXCL10
2hepatitis31.5IFNB1, CXCL10, XDH
3newcastle disease31.4IVNS1ABP, NEU1, CXCL10, IFNB1
4respiratory failure31.2CXCL10, NEU1, SFTPD
5encephalitis31.1MX1, CXCL10
6hemophagocytic lymphohistiocytosis31.0IFNB1, MX1
7arthritis31.0IVNS1ABP, PTPN11, CXCL10, MX1
8herpes simplex30.6MX1, IFNB1, CXCL10, NEU1
9malaria30.6NEU1, XDH
10asthma30.6XDH, SFTPD, NEU1, CXCL10, IFNB1, MX1
11hiv-130.5XDH, HLA-S, SFTPD, CXCL10
12systemic lupus erythematosus30.5PTPN11, CXCL10, IFNB1, MX1
13rheumatoid arthritis30.5IVNS1ABP, SFTPD, PTPN11, CXCL10, IFNB1
14rift valley fever30.4MX1
15japanese encephalitis30.4PTPN11, IVNS1ABP
16venezuelan equine encephalitis30.3FURIN
17hepatitis c30.2CXCL10, IFNB1, MX1
18adenocarcinoma29.9FURIN, SFTPD, CXCL10, IFNB1, MAGEA3, PDPN
19melanoma29.6DDX58, XDH, PTPN11, NEU1, CXCL10, IFNB1
20viral infectious disease29.3DDX58, XDH, HLA-S, IVNS1ABP, FURIN, PTPN11
21avian influenza11.2
22swine influenza11.2
23haemophilus influenzae11.1
24tetanus10.8
25pertussis10.7
26diphtheria10.7
27meningitis10.6
28epiglottitis10.6
29hepatitis b10.6
30otitis media10.5
31viral pneumonia10.5
32egg allergy10.5
33vaccinia10.5
34myocarditis10.5
35dengue hemorrhagic fever10.4IVNS1ABP, PTPN11
36bronchitis10.4
37acute disseminated encephalomyelitis10.4
38hydrops fetalis10.4PTPN11, NEU1
39leukemia10.4
40narcolepsy10.4
41mumps10.4
42myositis10.4
43poliomyelitis10.4
44atrophic gastritis10.4XDH, PTPN11
45relapsing-remitting multiple sclerosis10.3MX1, IFNB1
46measles10.3
47bronchopneumonia10.3
48febrile seizures10.3
49kaposi sarcoma10.3CXCL10, IFNB1, PDPN
50rubella10.3

Graphical network of the top 20 diseases related to Influenza:



Diseases related to influenza

Symptoms for Influenza

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Symptoms:

 9 (show all 8)
  • chills
  • fever
  • sore throat
  • runny nose
  • muscle pains
  • severe headache
  • cough
  • weakness

Drugs & Therapeutics for Influenza

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Drug clinical trials:

Search ClinicalTrials for Influenza

Search NIH Clinical Center for Influenza

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Influenza

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Anatomical Context for Influenza

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MalaCards organs/tissues related to Influenza:

31
Brain, T cells, Lung, Heart, Testes, Neutrophil, Monocytes, Colon, B cells, Nk cells, Liver, Bone, Kidney, Thyroid, Tonsil, Bone marrow, Endothelial, Spinal cord, Prostate, Eye, Skin, Myeloid, Trachea

FMA organs/tissues related to Influenza:

14
Respiratory tract

Animal Models for Influenza or affiliated genes

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MGI Mouse Phenotypes related to Influenza:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.9XDH, IVNS1ABP, SFTPD, PTPN11, NEU1, CXCL10
2MP:00053978.8DDX58, FURIN, SFTPD, PTPN11, NEU1, CXCL10
3MP:00053878.7MX2, DDX58, XDH, FURIN, SFTPD, PTPN11
4MP:00107688.4DDX58, XDH, IVNS1ABP, FURIN, SFTPD, PTPN11

Publications for Influenza

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Articles related to Influenza:

(show top 50)    (show all 3775)
idTitleAuthorsYear
1
Risk Reduction Modeling of High Pathogenicity Avian Influenza Virus Titers in Nonpasteurized Liquid Egg Obtained from Infected but Undetected Chicken Flocks. (25867713)
2015
2
Systemic Allergic Contact Dermatitis After Formaldehyde-Containing Influenza Vaccination. (25876644)
2015
3
Automated influenza-like illness reporting-an efficient adjunct to traditional sentinel surveillance. (24381360)
2014
4
Risk of Fever After Pediatric Trivalent Inactivated Influenza Vaccine and 13-Valent Pneumococcal Conjugate Vaccine. (24395025)
2014
5
Commentary on Zhang J, While AE and Norman IJ (2012) Development and testing of an instrument to assess nurses' knowledge, risk perception, health beliefs and behaviours related to influenza vaccination. Journal of Clinical Nursing 21, 2636-2646. (24313943)
2014
6
Haemophilus haemolyticus is infrequently misidentified as Haemophilus influenzae in diagnostic specimens in Australia. (25266675)
2014
7
Exposure to avian influenza H7N9 in farms and wet markets. (23664058)
2013
8
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). (22819125)
2013
9
Pathogenicity of an H5N1 highly pathogenic avian influenza virus isolated in the 2010-2011 winter in Japan to mandarin ducks. (23318574)
2013
10
Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function. (23548901)
2013
11
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
12
Genesis and genetic constellations of swine influenza viruses in Thailand. (24095146)
2013
13
Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers. (23080288)
2013
14
Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008. (23967241)
2013
15
Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus. (23265247)
2013
16
Complete Genome Sequence of Encapsulated Haemophilus influenzae Type f KR494, an Invasive Isolate That Caused Necrotizing Myositis. (24092777)
2013
17
Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins. (22318733)
2012
18
YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules. (22855482)
2012
19
Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. (22851708)
2012
20
Guillain-BarrAc syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: case report and review of the literature. (22000408)
2012
21
Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae. (22298528)
2012
22
Risk factors for avian influenza and Newcastle disease in smallholder farming systems, Madagascar highlands. (22130311)
2012
23
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
24
Expression of myeloperoxidase in swine influenza virus (SIV)-infected neutrophils in lungs from pigs experimentally infected with SIV subtype H1N2. (21688042)
2011
25
Experimental design to optimize an Haemophilus influenzae type b conjugate vaccine made with hydrazide-derivatized tetanus toxoid. (21850577)
2011
26
Cell-mediated immune responses to inactivated trivalent influenza-vaccination are decreased in patients with common variable immunodeficiency. (21889412)
2011
27
Isolation and Phylogenetic Analysis of H1N1 Swine Influenza Virus from Sick Pigs in Southern China. (23637505)
2011
28
Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling. (21288362)
2011
29
Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus. (20392922)
2010
30
Viral encephalitis associated with pandemic 2009 (H1N1) influenza A. (22767664)
2010
31
Differences in serum cytokine levels between influenza virus A and B infections in children. (19497758)
2009
32
Swine influenza: nephrologist's perspective. (19617670)
2009
33
Expression of mouse beta-defensin-3 in MDCK cells and its anti-influenza-virus activity. (19301094)
2009
34
Swine influenza: then and now. (19494369)
2009
35
The antibody responses to swine influenza virus (SIV) recombinant matrix 1 (rM1), matrix 2 (M2), and hemagglutinin (HA) proteins in pigs with different SIV exposure. (17719187)
2008
36
The role of p38 mitogen activated protein kinase in the inflammatory response of human monocytes infected with nontypeable Haemophilus influenzae]. (18953958)
2008
37
Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus. (16585542)
2006
38
p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. (16051807)
2005
39
The structure and receptor binding properties of the 1918 influenza hemagglutinin. (14764886)
2004
40
Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir. (12821478)
2003
41
Immune reactivity against a novel HLA-A3-restricted influenza virus peptide identified by predictive algorithms and interferon-gamma quantitative PCR. (12514428)
2003
42
Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees. (12141967)
2002
43
Management of influenza in patients with asthma or chronic obstructive pulmonary disease. (11770690)
2001
44
The 1-127 HA2 construct of influenza virus hemagglutinin induces cell-cell hemifusion. (11444985)
2001
45
Identification of a 374 amino acid protein encoded by RNA segment 6 of influenza C virus. (9747730)
1998
46
Regulation of HLA class I and II expression by interferons and influenza A virus in human peripheral blood mononuclear cells. (9301532)
1997
47
A strategy for theoretical binding constant, Ki, calculations for neuraminidase aromatic inhibitors designed on the basis of the active site structure of influenza virus neuraminidase. (8592707)
1995
48
In vitro activation of human T lymphocytes by Haemophilus influenzae type b capsular polysaccharides. (1346727)
1992
49
Purulent salpingitis and intra-uterine contraceptive device-related infection due to Haemophilus influenzae. (2002228)
1991
50
Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (2161946)
1990

Variations for Influenza

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Expression for genes affiliated with Influenza

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LifeMap Discovery
Genes differentially expressed in tissues of Influenza patients vs. healthy controls: 30 (show all 38)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1IFI27interferon, alpha-inducible protein 27Blood+6.130.000
2OTOFotoferlinBlood+5.570.000
3KCTD14potassium channel tetramerization domain containing 14Blood+5.450.000
4HESX1HESX homeobox 1Blood+4.330.000
5CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrialBlood+4.320.000
6CCNA1cyclin A1Blood+4.260.000
7METTL7Bmethyltransferase like 7BBlood+4.120.000
8C1QCcomplement component 1, q subcomponent, C chainBlood+4.110.000
9OLFM4olfactomedin 4Blood+3.990.000
10SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesinBlood+3.980.000
11RSAD2radical S-adenosyl methionine domain containing 2Blood+3.860.000
12GPR42G protein-coupled receptor 42 (gene/pseudogene)Blood+3.850.000
13RNASE1ribonuclease, RNase A family, 1 (pancreatic)Blood+3.830.000
14CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)Blood+3.800.000
15KCNE1potassium voltage-gated channel, Isk-related family, member 1Blood+3.730.000
16OAS32'-5'-oligoadenylate synthetase 3, 100kDaBlood+3.700.000
17TMEM119transmembrane protein 119Blood+3.660.000
18DNAAF1dynein, axonemal, assembly factor 1Blood+3.540.000
19HPhaptoglobinBlood+3.460.000
20IFI44Linterferon-induced protein 44-likeBlood+3.420.000
21PPARGperoxisome proliferator-activated receptor gammaBlood+3.380.000
22SLC26A8solute carrier family 26 (anion exchanger), member 8Blood+3.370.000
23IFITM4Pinterferon induced transmembrane protein 4 pseudogeneBlood+3.310.000
24IFIT1interferon-induced protein with tetratricopeptide repeats 1Blood+3.280.000
25LOC550643uncharacterized LOC550643Blood+3.270.005
26GPR84G protein-coupled receptor 84Blood+3.250.000
27IL27interleukin 27Blood+3.210.000
28SYN2synapsin IIBlood+3.200.000
29OAS12'-5'-oligoadenylate synthetase 1, 40/46kDaBlood+3.190.000
30HIST1H4Dhistone cluster 1, H4dBlood+3.160.000
31ISG15ISG15 ubiquitin-like modifierBlood+3.110.000
32IFIT3interferon-induced protein with tetratricopeptide repeats 3Blood+3.090.000
33EXOC3L1exocyst complex component 3-like 1Blood+3.090.000
34RSPH9radial spoke head 9 homolog (Chlamydomonas)Blood+3.080.000
35CD177CD177 moleculeBlood+3.040.000
36TCN2transcobalamin IIBlood+3.030.000
37IFI44interferon-induced protein 44Blood+3.030.000
38PLSCR1phospholipid scramblase 1Blood+3.010.000

Search GEO for disease gene expression data for Influenza.

Pathways for genes affiliated with Influenza

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Pathways related to Influenza according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
10.0SFTPD, CXCL10, IFNB1
2
Show member pathways
10.0IFNB1, CXCL10, DDX58
3
Show member pathways
10.0IFNB1, CXCL10, DDX58
410.0IFNB1, CXCL10, PTPN11
5
Show member pathways
9.7PTPN11, IFNB1, IFITM3, MX2, MX1
6
Show member pathways
9.5DDX58, PTPN11, IFNB1, IFITM3, MX2, MX1
7
Show member pathways
9.1MX1, DDX58, IVNS1ABP, FURIN, PTPN11, CPSF4

Compounds for genes affiliated with Influenza

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Compounds related to Influenza according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1rebif4310.5MX1, IFNB1
2avonex4310.5MX1, IFNB1
3betaseron4310.5MX1, IFNB1
4monosaccharide4310.4NEU1, SFTPD
52,5-oligoadenylate4310.3CXCL10, IFNB1, MX1
6acyclovir43 1211.3NEU1, IFNB1
7polyinosinic-polycytidylic acid4310.3DDX58, CXCL10, IFNB1
8neopterin4310.3MX1, IFNB1, CXCL10
9dtpa4310.3XDH, IFNB1
10ribavirin43 49 1212.2NEU1, CXCL10, IFNB1, MX1
11tetracycline43 1211.2IFNB1, PTPN11, FURIN
12poly(i-c)4310.2MX1, IFNB1, CXCL10, DDX58
13ifn-alpha4310.2PTPN11, CXCL10, IFNB1, MX1
14adenine43 24 1212.2IFNB1, CXCL10, XDH
15sialic acid4310.2NEU1, IFNB1, PDPN
16Beta-D-Glucose24 1211.2IFNB1, SFTPD
17imiquimod43 59 28 1213.1MX1, IFNB1
18polysaccharide4310.1SFTPD, NEU1, IFNB1, PDPN
19endotoxin4310.0IFNB1, CXCL10, SFTPD
20rantes4310.0DDX58, PTPN11, CXCL10, IFNB1, MX1
21cycloheximide4310.0DDX58, NEU1, CXCL10, IFNB1, MX1
22thymidine43 2411.0IFNB1, CXCL10, PTPN11, SFTPD
23alanine439.9FURIN, PTPN11, CXCL10, IFNB1, MX1
24adenylate439.9IVNS1ABP, FURIN, CPSF4, CXCL10, IFNB1
25cysteine439.8XDH, FURIN, SFTPD, PTPN11, NEU1, IFNB1
26lipid439.7XDH, FURIN, SFTPD, PTPN11, CXCL10, IFNB1
27serine439.5FURIN, SFTPD, PTPN11, NEU1, IFNB1, MX1
28glucose439.3FURIN, SFTPD, PTPN11, CXCL10, IFNB1

GO Terms for genes affiliated with Influenza

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Biological processes related to Influenza according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to interferon-alphaGO:003545510.2MX2, IFITM3
2negative regulation of viral genome replicationGO:004507110.2MX1, IFITM3, IFNB1
3response to exogenous dsRNAGO:004333010.1IFNB1, DDX58
4regulation of type I interferon-mediated signaling pathwayGO:006033810.0IFNB1, PTPN11
5type I interferon signaling pathwayGO:00603379.9PTPN11, IFNB1, IFITM3, MX2, MX1
6defense response to virusGO:00516079.8MX1, MX2, IFITM3, IFNB1, CXCL10
7cytokine-mediated signaling pathwayGO:00192219.8PTPN11, IFNB1, IFITM3, MX2, MX1
8lung alveolus developmentGO:00482869.8PDPN, SFTPD
9response to virusGO:00096159.7MX1, MX2, IFITM3, IFNB1, IVNS1ABP, DDX58
10innate immune responseGO:00450879.7DDX58, SFTPD, PTPN11, IFNB1, MX1

Products for genes affiliated with Influenza

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Sources for Influenza

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet