FLU
MCID: INF038
MIFTS: 68

Influenza (FLU) malady

Infectious diseases, Respiratory diseases categories
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Summaries for Influenza

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MedlinePlus:33 Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. most people with the flu recover on their own without medical care. people with mild cases of the flu should stay home and avoid contact with others, except to get medical care. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. the main way to keep from getting the flu is to get a yearly flu vaccine. good hygiene, including hand washing, can also help. nih: national institute of allergy and infectious diseases

MalaCards based summary: Influenza, also known as influenza with non-respiratory manifestation, is related to pneumonia and hepatitis, and has symptoms including An important gene associated with Influenza is IFITM3 (interferon induced transmembrane protein 3), and among its related pathways are Immune response Bacterial infections in normal airways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drug influenza neuraminidase inhibitor [epc] and the compounds rebif and avonex have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, t cells and lung, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

Wikipedia:65 Influenza, commonly known as \"the flu\", is an infectious disease of birds and mammals caused by RNA... more...

Aliases & Classifications for Influenza

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Influenza, Aliases & Descriptions:

Name: Influenza 8 10 44 62
Influenza with Non-Respiratory Manifestation 8 62
Influenza with Other Manifestations 8 62
 
Flu 8 33
Influenza with Other Manifestations Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:8469
ICD9CM27 487
NCIt39 C53482
MeSH34 D007251

Related Diseases for Influenza

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Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 442)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7CXCL10, XDH, SFTPD, NEU1
2hepatitis31.5XDH, CXCL10, IFNB1
3newcastle disease31.4IFNB1, IVNS1ABP, NEU1, CXCL10
4respiratory failure31.2SFTPD, NEU1, CXCL10
5encephalitis31.1MX1, CXCL10
6hemophagocytic lymphohistiocytosis31.0MX1, IFNB1
7arthritis31.0IVNS1ABP, MX1, CXCL10, PTPN11
8sepsis30.8NEU1, XDH, FURIN, SFTPD
9chronic obstructive pulmonary disease30.6CXCL10, SFTPD, XDH
10herpes simplex30.6NEU1, CXCL10, IFNB1, MX1
11systemic lupus erythematosus30.6PTPN11, CXCL10, MX1, IFNB1
12malaria30.6NEU1, XDH
13asthma30.6MX1, IFNB1, CXCL10, NEU1, SFTPD, XDH
14rheumatoid arthritis30.5CXCL10, IVNS1ABP, SFTPD, PTPN11, IFNB1
15rift valley fever30.4MX1
16japanese encephalitis30.4IVNS1ABP, PTPN11
17venezuelan equine encephalitis30.3FURIN
18kaposi's sarcoma30.2IFNB1, CXCL10, PDPN
19hepatitis c30.2CXCL10, MX1, IFNB1
20sarcoidosis30.1HLA-S, SFTPD, CXCL10
21multiple sclerosis30.1XDH, MX1, IFNB1, CXCL10
22adenocarcinoma29.9CXCL10, PDPN, SFTPD, FURIN, MAGEA3, IFNB1
23melanoma29.7PTPN11, PDPN, MAGEA3, IFNB1, CXCL10, MX1
24avian influenza11.2
25swine influenza11.2
26haemophilus influenzae11.1
27tetanus10.8
28pertussis10.7
29diphtheria10.7
30meningitis10.6
31epiglottitis10.6
32hepatitis b10.6
33otitis media10.5
34viral pneumonia10.5
35vaccinia10.5
36dengue hemorrhagic fever10.4PTPN11, IVNS1ABP
37myocarditis10.4
38bronchitis10.4
39egg allergy10.4
40hydrops fetalis10.4PTPN11, NEU1
41leukemia10.4
42narcolepsy10.4
43acute disseminated encephalomyelitis10.4
44atrophic gastritis10.4XDH, PTPN11
45mumps10.4
46relapsing-remitting multiple sclerosis10.4MX1, IFNB1
47bronchopneumonia10.3
48measles10.3
49guillain-barre syndrome10.3
50myositis10.3

Graphical network of the top 20 diseases related to Influenza:



Diseases related to influenza

Symptoms for Influenza

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Drugs & Therapeutics for Influenza

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Drug clinical trials:

Search ClinicalTrials for Influenza

Search NIH Clinical Center for Influenza

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Influenza

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Anatomical Context for Influenza

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MalaCards organs/tissues related to Influenza:

32
T cells, Lung, Testes, Monocytes, Neutrophil, Heart, Colon, B cells, Brain, Nk cells, Bone, Kidney, Thyroid, Tonsil, Bone marrow, Endothelial, Spinal cord, Liver, Prostate, Eye, Skin, Myeloid, Trachea

FMA organs/tissues related to Influenza:

14
Respiratory tract

Animal Models for Influenza or affiliated genes

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MGI Mouse Phenotypes related to Influenza:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.9XDH, IVNS1ABP, SFTPD, PTPN11, NEU1, CXCL10
2MP:00053978.8DDX58, FURIN, SFTPD, PTPN11, NEU1, CXCL10
3MP:00053878.7MX2, DDX58, XDH, FURIN, SFTPD, PTPN11
4MP:00107688.4DDX58, XDH, IVNS1ABP, FURIN, SFTPD, PTPN11

Publications for Influenza

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Articles related to Influenza:

(show top 50)    (show all 3680)
idTitleAuthorsYear
1
Automated influenza-like illness reporting-an efficient adjunct to traditional sentinel surveillance. (24381360)
2014
2
Risk of Fever After Pediatric Trivalent Inactivated Influenza Vaccine and 13-Valent Pneumococcal Conjugate Vaccine. (24395025)
2014
3
Commentary on Zhang J, While AE and Norman IJ (2012) Development and testing of an instrument to assess nurses' knowledge, risk perception, health beliefs and behaviours related to influenza vaccination. Journal of Clinical Nursing 21, 2636-2646. (24313943)
2014
4
Haemophilus haemolyticus is infrequently misidentified as Haemophilus influenzae in diagnostic specimens in Australia. (25266675)
2014
5
Exposure to avian influenza H7N9 in farms and wet markets. (23664058)
2013
6
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). (22819125)
2013
7
Pathogenicity of an H5N1 highly pathogenic avian influenza virus isolated in the 2010-2011 winter in Japan to mandarin ducks. (23318574)
2013
8
Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function. (23548901)
2013
9
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
10
Genesis and genetic constellations of swine influenza viruses in Thailand. (24095146)
2013
11
Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers. (23080288)
2013
12
Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008. (23967241)
2013
13
Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus. (23265247)
2013
14
Complete Genome Sequence of Encapsulated Haemophilus influenzae Type f KR494, an Invasive Isolate That Caused Necrotizing Myositis. (24092777)
2013
15
Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins. (22318733)
2012
16
YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules. (22855482)
2012
17
Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. (22851708)
2012
18
Guillain-BarrAc syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: case report and review of the literature. (22000408)
2012
19
Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae. (22298528)
2012
20
Risk factors for avian influenza and Newcastle disease in smallholder farming systems, Madagascar highlands. (22130311)
2012
21
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
22
Expression of myeloperoxidase in swine influenza virus (SIV)-infected neutrophils in lungs from pigs experimentally infected with SIV subtype H1N2. (21688042)
2011
23
Experimental design to optimize an Haemophilus influenzae type b conjugate vaccine made with hydrazide-derivatized tetanus toxoid. (21850577)
2011
24
Cell-mediated immune responses to inactivated trivalent influenza-vaccination are decreased in patients with common variable immunodeficiency. (21889412)
2011
25
Isolation and Phylogenetic Analysis of H1N1 Swine Influenza Virus from Sick Pigs in Southern China. (23637505)
2011
26
Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling. (21288362)
2011
27
Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus. (20392922)
2010
28
Viral encephalitis associated with pandemic 2009 (H1N1) influenza A. (22767664)
2010
29
Differences in serum cytokine levels between influenza virus A and B infections in children. (19497758)
2009
30
Swine influenza: nephrologist's perspective. (19617670)
2009
31
Expression of mouse beta-defensin-3 in MDCK cells and its anti-influenza-virus activity. (19301094)
2009
32
Swine influenza: then and now. (19494369)
2009
33
The antibody responses to swine influenza virus (SIV) recombinant matrix 1 (rM1), matrix 2 (M2), and hemagglutinin (HA) proteins in pigs with different SIV exposure. (17719187)
2008
34
The role of p38 mitogen activated protein kinase in the inflammatory response of human monocytes infected with nontypeable Haemophilus influenzae]. (18953958)
2008
35
Outcome of influenza infection managed with oseltamivir in lung transplant recipients. (18342750)
2008
36
Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus. (16585542)
2006
37
p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. (16051807)
2005
38
The structure and receptor binding properties of the 1918 influenza hemagglutinin. (14764886)
2004
39
Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir. (12821478)
2003
40
Immune reactivity against a novel HLA-A3-restricted influenza virus peptide identified by predictive algorithms and interferon-gamma quantitative PCR. (12514428)
2003
41
Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees. (12141967)
2002
42
Management of influenza in patients with asthma or chronic obstructive pulmonary disease. (11770690)
2001
43
The 1-127 HA2 construct of influenza virus hemagglutinin induces cell-cell hemifusion. (11444985)
2001
44
Identification of a 374 amino acid protein encoded by RNA segment 6 of influenza C virus. (9747730)
1998
45
Regulation of HLA class I and II expression by interferons and influenza A virus in human peripheral blood mononuclear cells. (9301532)
1997
46
A strategy for theoretical binding constant, Ki, calculations for neuraminidase aromatic inhibitors designed on the basis of the active site structure of influenza virus neuraminidase. (8592707)
1995
47
In vitro activation of human T lymphocytes by Haemophilus influenzae type b capsular polysaccharides. (1346727)
1992
48
Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus. (1321288)
1992
49
Purulent salpingitis and intra-uterine contraceptive device-related infection due to Haemophilus influenzae. (2002228)
1991
50
Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (2161946)
1990

Variations for Influenza

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Expression for genes affiliated with Influenza

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Expression patterns in normal tissues for genes affiliated with Influenza

Search GEO for disease gene expression data for Influenza.

Pathways for genes affiliated with Influenza

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Pathways related to Influenza according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
10.0SFTPD, CXCL10, IFNB1
2
Show member pathways
10.0IFNB1, CXCL10, DDX58
3
Show member pathways
10.0IFNB1, CXCL10, DDX58
410.0IFNB1, CXCL10, PTPN11
5
Show member pathways
9.7PTPN11, IFNB1, IFITM3, MX2, MX1
6
Show member pathways
9.5DDX58, PTPN11, IFNB1, IFITM3, MX2, MX1
7
Show member pathways
9.1MX1, DDX58, IVNS1ABP, FURIN, PTPN11, CPSF4

Compounds for genes affiliated with Influenza

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Compounds related to Influenza according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1rebif4410.5MX1, IFNB1
2avonex4410.5MX1, IFNB1
3betaseron4410.5MX1, IFNB1
4monosaccharide4410.4NEU1, SFTPD
52,5-oligoadenylate4410.3CXCL10, IFNB1, MX1
6acyclovir44 1111.3NEU1, IFNB1
7polyinosinic-polycytidylic acid4410.3DDX58, CXCL10, IFNB1
8neopterin4410.3MX1, IFNB1, CXCL10
9dtpa4410.3XDH, IFNB1
10ribavirin44 50 1112.2NEU1, CXCL10, IFNB1, MX1
11tetracycline44 1111.2IFNB1, PTPN11, FURIN
12poly(i-c)4410.2MX1, IFNB1, CXCL10, DDX58
13ifn-alpha4410.2PTPN11, CXCL10, IFNB1, MX1
14adenine44 24 1112.2IFNB1, CXCL10, XDH
15sialic acid4410.2NEU1, IFNB1, PDPN
16Beta-D-Glucose24 1111.2IFNB1, SFTPD
17imiquimod44 61 28 1113.1MX1, IFNB1
18polysaccharide4410.1SFTPD, NEU1, IFNB1, PDPN
19endotoxin4410.0IFNB1, CXCL10, SFTPD
20rantes4410.0DDX58, PTPN11, CXCL10, IFNB1, MX1
21cycloheximide4410.0DDX58, NEU1, CXCL10, IFNB1, MX1
22thymidine44 2411.0IFNB1, CXCL10, PTPN11, SFTPD
23alanine449.9FURIN, PTPN11, CXCL10, IFNB1, MX1
24adenylate449.9IVNS1ABP, FURIN, CPSF4, CXCL10, IFNB1
25cysteine449.8XDH, FURIN, SFTPD, PTPN11, NEU1, IFNB1
26lipid449.7XDH, FURIN, SFTPD, PTPN11, CXCL10, IFNB1
27serine449.5FURIN, SFTPD, PTPN11, NEU1, IFNB1, MX1
28glucose449.3FURIN, SFTPD, PTPN11, CXCL10, IFNB1

GO Terms for genes affiliated with Influenza

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Biological processes related to Influenza according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to interferon-alphaGO:03545510.2MX2, IFITM3
2negative regulation of viral genome replicationGO:04507110.2MX1, IFITM3, IFNB1
3response to exogenous dsRNAGO:04333010.1IFNB1, DDX58
4regulation of type I interferon-mediated signaling pathwayGO:06033810.0IFNB1, PTPN11
5type I interferon signaling pathwayGO:0603379.9PTPN11, IFNB1, IFITM3, MX2, MX1
6defense response to virusGO:0516079.8MX1, MX2, IFITM3, IFNB1, CXCL10
7cytokine-mediated signaling pathwayGO:0192219.8PTPN11, IFNB1, IFITM3, MX2, MX1
8lung alveolus developmentGO:0482869.8PDPN, SFTPD
9response to virusGO:0096159.7MX1, MX2, IFITM3, IFNB1, IVNS1ABP, DDX58
10innate immune responseGO:0450879.7DDX58, SFTPD, PTPN11, IFNB1, MX1

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Sources for Influenza

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet