FLU
MCID: INF038
MIFTS: 69

Influenza (FLU) malady

Summaries for Influenza

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. most people with the flu recover on their own without medical care. people with mild cases of the flu should stay home and avoid contact with others, except to get medical care. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. the main way to keep from getting the flu is to get a yearly flu vaccine. good hygiene, including hand washing, can also help. nih: national institute of allergy and infectious diseases

MalaCards: Influenza, also known as FLU, is related to pneumonia and hepatitis, and has symptoms including fever, chills and runny nose. An important gene associated with Influenza is MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)), and among its related pathways are Influenza A and Interferon Signaling. The drug influenza neuraminidase inhibitor [epc] and the compounds cysteine and lipid have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, t cells and lung, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

CDC:3 Flu activity is low in most of the United States, but a wave of influenza B virus activity is affecting parts of the country. It's possible that significant flu activity could continue into May. CDC still recommends that people get a flu vaccine if they have not yet this season. And remember that flu antiviral drugs are a second line of defense to treat flu illness. People at high risk of serious flu illness should call a health care provider if they get flu symptoms.

Wikipedia:63 Influenza, commonly known as \"the flu\", is an infectious disease of birds and mammals caused by RNA... more...

Aliases & Classifications for Influenza

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Aliases & Descriptions:

influenza 8 10 44 60
flu 8 33
influenza with non-respiratory manifestation 8
influenza with other manifestations nos 8
influenza with other manifestations 8


External Ids:

Disease Ontology8 DOID:8469
ICD9CM27 487
MeSH34 D007251
NCIt39 C53482

Related Diseases for Influenza

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17GeneCards, 18GeneDecks
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Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 398)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.2SFTPD, NEU1, XDH, CXCL10
2hepatitis30.9IFNB1, XDH, CXCL10
3newcastle disease30.9IFNB1, NEU1, IVNS1ABP, CXCL10
4meningitis30.8CXCL10
5hepatitis b30.8MX1, CXCL10, IFNG
6vaccinia30.5FURIN
7respiratory failure30.5SFTPD
8arthritis30.5PTPN11, MX1, CXCL10, IVNS1ABP, IFNG
9mumps30.4NEU1
10measles30.4MX1, IFNB1
11encephalitis30.4MX1, CXCL10
12asthma30.3SFTPD, IFNG, IFNB1, NEU1, XDH, CXCL10
13severe acute respiratory syndrome30.3CXCL10
14aspergillosis30.3SFTPD, IFNG
15cystic fibrosis30.3FURIN, SFTPD
16rheumatoid arthritis30.2SFTPD, IFNG, IFNB1, IVNS1ABP, CXCL10, PTPN11
17systemic lupus erythematosus30.2PTPN11, MX1, CXCL10, IFNB1, IFNG
18hemophagocytic lymphohistiocytosis30.2IFNB1, MX1
19lupus erythematosus30.2MX1
20herpes simplex30.1MX1, CXCL10, NEU1, IFNB1
21chagas disease30.0NEU1
22hepatitis c29.9IFNG, IFNB1, CXCL10, MX1
23dermatomyositis29.9SFTPD, MX1
24allergic asthma29.9IFNB1, IFNG, SFTPD
25melanoma29.8IFNG, IFNB1, PDPN, NEU1, MAGEA3, XDH
26adenocarcinoma29.8SFTPD, IFNB1, PDPN, MAGEA3, CXCL10, FURIN
27malaria29.8XDH, NEU1, IFNG
28tuberculosis29.8SFTPD, IFNG, IFNB1, CXCL10
29diabetes mellitus29.8PTPN11, NEU1
30viral infectious disease29.8IFNG, IFNB1, NEU1, IVNS1ABP, XDH, CXCL10
31skin disease29.8SFTPD, IFNG, CXCL10, MX1
32alopecia areata29.8IFNG
33multiple sclerosis29.6IFNG, IFNB1, XDH, CXCL10, MX1
34sepsis29.6SFTPD, NEU1, XDH, FURIN
35kaposi's sarcoma29.6CXCL10, PDPN, IFNB1
36uveitis29.6CXCL10, IFNG
37sarcoidosis29.6SFTPD, IFNG, CXCL10
38japanese encephalitis29.6PTPN11, IVNS1ABP
39neutropenia29.6CXCL10, IFNB1
40lichen planus29.6MX1
41venezuelan equine encephalitis29.6FURIN
42bronchiolitis obliterans29.6CXCL10
43chronic inflammatory demyelinating polyradiculoneuropathy29.6IFNB1
44avian influenza11.1
45swine influenza11.1
46tetanus10.7
47pertussis10.6
48diphtheria10.6
49epiglottitis10.6
50hepatitis a10.5

Graphical network of the top 20 diseases related to Influenza:



Diseases related to influenza

Clinical Features for Influenza

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 8)
  • fever
  • chills
  • runny nose
  • muscle pains
  • sore throat
  • weakness
  • severe headache
  • cough

Drugs & Therapeutics for Influenza

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Influenza

Drug clinical trials:

Search ClinicalTrials for Influenza

Search NIH Clinical Center for Influenza

Search CenterWatch for Influenza

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Influenza

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Anatomical Context for Influenza

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Influenza:

32
T cells, Lung, Testes, Monocytes, Heart, Colon, B cells, Brain, Nk cells, Bone, Thyroid, Tonsil, Endothelial, Bone marrow, Kidney, Trachea, Spinal cord, Liver, Eye, Skin, Myeloid, Prostate

FMA organs/tissues related to Influenza:

14
Respiratory tract

Animal Models for Influenza or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Influenza:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.0PTPN11, SFTPD, IFNG, IFNB1, PDPN, NEU1
2MP:000538511.8PDPN, NEU1, IVNS1ABP, XYLB, CXCL10, PTPN11
3MP:000538711.7SFTPD, IFNG, IFNB1, PDPN, NEU1, XDH

Publications for Influenza

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Sources:
50PubMed
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Articles related to Influenza:

(show top 50)    (show all 3562)
idTitleAuthorsYear
1
Automated influenza-like illness reporting-an efficient adjunct to traditional sentinel surveillance. (24381360)
2014
2
Commentary on Zhang J, While AE and Norman IJ (2012) Development and testing of an instrument to assess nurses' knowledge, risk perception, health beliefs and behaviours related to influenza vaccination. Journal of Clinical Nursing 21, 2636-2646. (24313943)
2014
3
Seasonal influenza vaccination at school: a randomized controlled trial. (24355665)
2014
4
Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus. (24419622)
2014
5
Contact Tracing for Influenza A(H1N1)pdm09 Virus-infected Passenger on International Flight. (24377724)
2014
6
Cloning and expression of a codon-optimized gene encoding the influenza A virus nucleocapsid protein in Lactobacillus casei. (24400527)
2013
7
In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus. (24311151)
2013
8
Influenza sentinel surveillance: Michigan physicians needed for upcoming flu season. (24354124)
2013
9
Inhibition of influenza virus in vivo by siRNA delivered using ABA triblock copolymer synthesized by reversible addition-fragmentation chain-transfer polymerization. (24364874)
2013
10
Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epithelium. (23775183)
2013
11
Drugs against Avian Influenza A Virus: Design of Novel Sulfonate Inhibitors of Neuraminidase N1. (24001233)
2013
12
Modulation of an Ectodomain Motif in the Influenza A Virus Neuraminidase Alters Tetherin Sensitivity and Results in Virus Attenuation In Vivo. (24380762)
2013
13
Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus. (23487453)
2013
14
Antigenicity and transmissibility of a novel clade 2.3.2.1 avian influenza H5N1 virus. (24077367)
2013
15
Rhabdomyolysis-induced acute renal failure associated with 2009 influenza A (H1N1) virus infection in a child with Crigler-Najjar syndrome. (20828972)
2012
16
Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity. (22124123)
2012
17
Entry of influenza A Virus with a I+2,6-linked sialic acid binding preference requires host fibronectin. (22837202)
2012
18
Three children with plastic bronchitis associated with 2009 H1N1 influenza virus infection. (20686435)
2011
19
Molecular characterization and pathogenicity of swine influenza H9N2 subtype virus A/swine/HeBei/012/2008/(H9N2). (21978155)
2011
20
Longitudinal study on the seroprevalence of avian influenza, leptospirosis, and tularemia in an urban population of raccoons (Procyon lotor) in Ontario, Canada. (20491583)
2011
21
Carbon nanotube electric immunoassay for the detection of swine influenza virus H1N1. (21354779)
2011
22
Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. (21628863)
2011
23
Toll-like receptor 3 is involved in airway epithelial cell response to nontypeable Haemophilus influenzae. (19878930)
2010
24
A case of chronic fatigue syndrome triggered by influenza H1N1 (swine influenza). (19858526)
2010
25
Duration of immunity induced by an equine influenza and tetanus combination vaccine formulation adjuvanted with ISCOM-Matrix. (20728523)
2010
26
Developing new antiviral agents for influenza treatment: what does the future hold? (19067613)
2009
27
Prevention and treatment of influenza]. (19044051)
2008
28
Influenza viruses with reduced sensitivity to the neuraminidase inhibitor drugs in untreated young children. (18522305)
2008
29
Enzymatic properties of the neuraminidase of seasonal H1N1 influenza viruses provide insights for the emergence of natural resistance to oseltamivir. (18654625)
2008
30
Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells. (17270230)
2007
31
Antigenic and genetic characterization of H9N2 swine influenza viruses in China. (17554038)
2007
32
Multiple anti-interferon actions of the influenza A virus NS1 protein. (17442719)
2007
33
High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly. (16707559)
2006
34
Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity. (14764714)
2004
35
Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E. (12755627)
2003
36
Haemophilus influenzae septic abortion. (12625973)
2002
37
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. (9920933)
1999
38
Regulation of HLA class I and II expression by interferons and influenza A virus in human peripheral blood mononuclear cells. (9301532)
1997
39
Some virological and pathomorphological aspects of the respiratory system in the experimental infection with respiratory syncytial virus associated with influenza virus, parainfluenza virus type 3 and adenovirus in the mouse. (9495783)
1996
40
Fusion of influenza virus with sialic acid-bearing target membranes. (8117654)
1994
41
Influenza A virus-specific cytotoxic T lymphocyte activity declines with advancing age. (8418115)
1993
42
Environmental chemoprevention of Haemophilus influenzae type B meningitis. Consequences of 2 indirectly related case pairs]. (1640949)
1992
43
Effect of immunomodulator thymopentin on impaired seroresponse to influenza vaccine in patients on haemodialysis. (2183079)
1990
44
Nucleotide sequence and some biological properties of the NS gene of a newly isolated influenza B virus mutant which has a long carboxyl terminal deletion in the NS1 protein. (2136779)
1990
45
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
46
Bacteremic epididymo-orchitis due to hemophilus influenzae type B. (6976441)
1981
47
An erysipelas-like scalp cellulitis due to haemophilus influenzae type b. (6965310)
1980
48
Influence of experimental influenza infection of the eye on the course of herpetic keratitis in rabbits. (35945)
1978
49
Hemophilus influenzae bronchopneumonia in adults. (5645719)
1968
50
Haemophilus influenza type b orbital cellulitis. (6057129)
1967

Genetic Variations for Influenza

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Expression for genes affiliated with Influenza

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Influenza

Search GEO for disease gene expression data for Influenza.

Pathways for genes affiliated with Influenza

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Influenza

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Influenza according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1cysteine4412.0SFTPD, IFNG, IFNB1, NEU1, XDH, PTPN11
2lipid4411.9SFTPD, IFNB1, XDH, CXCL10, MX1, PTPN11
3ifn-alpha4411.7IFNG, IFNB1, CXCL10, MX1, PTPN11
4rantes4411.7PTPN11, MX1, CXCL10, IFNB1, IFNG
5thymidine44 2412.6PTPN11, CXCL10, IFNB1, IFNG, SFTPD
6adenylate4411.5IFNB1, IVNS1ABP, CXCL10, FURIN, CPSF4
72,5-oligoadenylate4411.5IFNG, IFNB1, CXCL10, MX1
8poly(i-c)4411.5MX1, CXCL10, IFNB1, IFNG
9neopterin4411.5IFNG, IFNB1, CXCL10, MX1
10ribavirin44 49 1113.4MX1, NEU1, IFNG
11betaseron4411.4MX1, IFNB1, IFNG
12acyclovir44 1112.3IFNG, IFNB1, NEU1
13imiquimod44 28 59 1114.3MX1, IFNB1, IFNG
14con a4411.3IFNG, NEU1, FURIN
15fluticasone propionate44 49 59 1114.3CXCL10, IFNB1, IFNG
16gsno4411.3IFNG, XDH, CXCL10
17polyinosinic-polycytidylic acid4411.3CXCL10, IFNB1, IFNG
18il 104411.3IFNG, IFNB1, CXCL10
19polysaccharide4411.3SFTPD, IFNB1, PDPN, NEU1
20tarc4411.3CXCL10, IFNB1, IFNG
21ccl344 2812.3IFNG, IFNB1, CXCL10
22allergens4411.2CXCL10, IFNG, SFTPD
23cycloheximide4411.2MX1, CXCL10, IFNB1
24rebif4411.2MX1, IFNB1
25carboplatin44 49 1113.2IFNG, IFNB1, XDH
26tetracycline44 1112.1FURIN, PTPN11, IFNB1
27avonex4411.1MX1, IFNB1
28histamine44 28 2413.1SFTPD, IFNG, NEU1, CXCL10
29sodium stibogluconate44 1112.1IFNG, PTPN11
30mezerein4410.9IFNB1, IFNG
31kynurenine4410.9IFNB1, IFNG
32monosaccharide4410.8NEU1, SFTPD
33d penicillamine4410.7XDH, IFNG
34glatiramer acetate44 1111.5IFNB1, IFNG

GO Terms for genes affiliated with Influenza

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16Gene Ontology
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Biological processes related to Influenza according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922111.7IFNG, IFITM3, IFNB1, MX1, MX2, PTPN11
2type I interferon-mediated signaling pathwayGO:06033711.5PTPN11, MX2, MX1, IFNB1, IFITM3
3response to virusGO:00961511.5IFNG, IFITM3, IFNB1, IVNS1ABP, MX1
4defense response to virusGO:05160711.5IFNG, IFITM3, IFNB1, CXCL10, MX1
5negative regulation of viral genome replicationGO:04507111.1MX1, IFNB1, IFITM3
6positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.9IFNG, IFNB1
7negative regulation of viral transcriptionGO:03289710.9IFITM3, IFNB1
8negative regulation of viral entry into host cellGO:04659710.8IFNB1, IFITM3
9adaptive immune responseGO:00225010.8IFNB1, IFNG
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IFNG, FURIN
11regulation of interferon-gamma-mediated signaling pathwayGO:06033410.5PTPN11, IFNG

Products for genes affiliated with Influenza

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Influenza

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet