FLU
MCID: INF038
MIFTS: 63

Influenza (FLU) malady

Summaries for Influenza

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. most people with the flu recover on their own without medical care. people with mild cases of the flu should stay home and avoid contact with others, except to get medical care. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. the main way to keep from getting the flu is to get a yearly flu vaccine. good hygiene, including hand washing, can also help. nih: national institute of allergy and infectious diseases

MalaCards: Influenza, also known as FLU, is related to newcastle disease and hepatitis c, and has symptoms including cough, fever and chills. An important gene associated with Influenza is MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)), and among its related pathways are Influenza A and Interferon Signaling. The drug influenza neuraminidase inhibitor [epc] and the compounds cysteine and lipid have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

CDC:3 Flu activity is widespread in most of the country. High levels of flu activity are likely to continue for several weeks. If you have not gotten your flu vaccination yet this season, you should get one now. A flu vaccine is the first and best way to protect yourself and the people around you from influenza and its potentially serious complications.New! Clinician advisory for 2013-2014 flu season.

Wikipedia:64 Influenza, commonly known as \"the flu\", is an infectious disease of birds and mammals caused by RNA... more...

Aliases & Classifications for Influenza

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

influenza 8 10 45 61
flu 8 34
influenza with non-respiratory manifestation 8
influenza with other manifestations nos 8
influenza with other manifestations 8


External Ids:

Disease Ontology8 DOID:8469
ICD9CM27 487
MeSH35 D007251
NCIt40 C53482

Related Diseases for Influenza

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Influenza family:

influenza, severe

Diseases related to Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 370)
idRelated DiseaseScoreTop Affiliating Genes
1newcastle disease30.9IFNB1, NEU1, IVNS1ABP, CXCL10
2hepatitis c30.8IFNG, IFNB1, CXCL10, MX1
3vaccinia30.6FURIN
4arthritis30.6PTPN11, MX1, CXCL10, IVNS1ABP, IFNG
5mumps30.5NEU1
6measles30.5MX1, IFNB1
7asthma30.5SFTPD, IFNG, IFNB1, NEU1, XDH, CXCL10
8severe acute respiratory syndrome30.4CXCL10
9aspergillosis30.3SFTPD, IFNG
10sepsis30.3SFTPD, NEU1, XDH, FURIN
11cystic fibrosis30.3FURIN, SFTPD
12hepatitis b30.3MX1, CXCL10, IFNG
13systemic lupus erythematosus30.2PTPN11, MX1, CXCL10, IFNB1, IFNG
14hemophagocytic lymphohistiocytosis30.2IFNB1, MX1
15pulmonary disease, chronic obstructive30.1CXCL10, XDH, SFTPD
16chagas disease30.0NEU1
17allergic asthma30.0IFNB1, IFNG, SFTPD
18adenocarcinoma29.9SFTPD, IFNB1, PDPN, MAGEA3, CXCL10, FURIN
19tuberculosis29.9SFTPD, IFNG, IFNB1, CXCL10
20viral infectious disease29.8IFNG, IFNB1, NEU1, IVNS1ABP, XDH, CXCL10
21alopecia areata29.8IFNG
22kaposi's sarcoma29.6CXCL10, PDPN, IFNB1
23uveitis29.6CXCL10, IFNG
24japanese encephalitis29.6PTPN11, IVNS1ABP
25lichen planus29.6MX1
26venezuelan equine encephalitis29.6FURIN
27bronchiolitis obliterans29.6CXCL10
28chronic inflammatory demyelinating polyradiculoneuropathy29.6IFNB1
29avian influenza11.2
30swine influenza11.2
31tetanus10.7
32diphtheria10.7
33influenza, severe10.7
34guillain-barr� syndrome10.6
35epiglottitis10.6
36hepatitis d10.5
37hepatitis a10.5
38viral pneumonia10.5
39bronchitis10.4
40acute disseminated encephalomyelitis10.4
41narcolepsy10.4
42n syndrome10.3
43febrile seizures10.3
44rubella10.3
45bronchopneumonia10.3
46reye syndrome10.3
47cellulitis10.3
48stomatitis10.3
49common cold10.3
50adult syndrome10.3

Graphical network of the top 20 diseases related to Influenza:



Diseases related to influenza

Clinical Features for Influenza

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 8)
  • cough
  • fever
  • chills
  • runny nose
  • muscle pains
  • sore throat
  • weakness
  • severe headache

Drugs & Therapeutics for Influenza

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Influenza

Drug clinical trials:

Search ClinicalTrials for Influenza

Search NIH Clinical Center for Influenza

Search CenterWatch for Influenza

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Influenza

Anatomical Context for Influenza

Sources:
14FMA
See all sources

FMA organs/tissues related to Influenza:

14
Respiratory tract

Animal Models for Influenza or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Influenza

Sources:
51PubMed
See all sources

Articles related to Influenza:

(show top 50)    (show all 3578)
idTitleAuthorsYear
1
A scientific sequel to Stieg Larsson: relationship between Pandemrix - pandemic influenza vaccine - and the subsequent development of narcolepsy. (24286291)
2014
2
Influenza Vaccination Effectiveness, Unmeasured Confounding, and Immunomodulatory Treatment. (24342988)
2014
3
Genetic characterization of H1N2 swine influenza virus isolated in China and its pathogenesis and inflammatory responses in mice. (23591972)
2013
4
CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy. (24353159)
2013
5
Investigation on the source of infection regarding an avian influenza (H7N9) in Changxing, Zhejiang province. (24147291)
2013
6
The battle between influenza and the innate immune response in the human respiratory tract. (24265946)
2013
7
A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers. (24386385)
2013
8
Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. (23440501)
2013
9
Short and long-term effects of pandemic unadjuvanted influenza A(H1N1)pdm09 vaccine on clinical manifestations and autoantibody profile in primary SjAPgren's syndrome. (23395584)
2013
10
The influenza virus: disease, diagnostics, and treatment. (24313126)
2013
11
Willingness to receive a hypothetical avian influenza vaccine among US military personnel in mid-deployment. (23917256)
2013
12
How can we increase seasonal influenza vaccine coverage in nursing home residents? (24286709)
2013
13
Success Factors for Avian Influenza Vaccine Use in Poultry and Potential Impact at the Wild Bird-Agricultural Interface. (24026475)
2013
14
Impact of swine influenza and quarantine measures on patients and households during the H1N1/09 pandemic. (22106922)
2012
15
Different replication profiles in specific-pathogen-free chickens of two H7 low pathogenic avian influenza viruses isolated from wild birds. (23402119)
2012
16
Persistence of avian influenza viruses in various artificially frozen environmental water types. (23091712)
2012
17
N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN. (21191006)
2011
18
Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo. (21641936)
2011
19
Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines. (21159878)
2011
20
Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity. (21551252)
2011
21
Pericardial effusion complicating novel influenza A (H1N1) infection in an infant. (20661108)
2010
22
H1N1 influenza A presenting as bacterial tracheitis. (20304287)
2010
23
Efficacy of inactivated swine influenza virus vaccines against the 2009 A/H1N1 influenza virus in pigs. (20132919)
2010
24
Necrotising fasciitis complicating Haemophilus influenzae type b epiglottitis in an adult. (19930753)
2010
25
Targeted vs. systematic early antiviral treatment against A(H1N1)v influenza with neuraminidase inhibitors in patients with influenza-like symptoms: clinical and economic impact. (20029659)
2009
26
Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. (19386707)
2009
27
Reassortment patterns in Swine influenza viruses. (20029610)
2009
28
Development of a live-attenuated influenza B DeltaNS1 intranasal vaccine candidate. (19366569)
2009
29
In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate. (19435511)
2009
30
Thermal inactivation of avian influenza and Newcastle disease viruses in chicken meat. (18592748)
2008
31
Central hypoventilation syndrome after Haemophilus influenzae type b meningitis and herpes infection. (18940561)
2008
32
Influenza in children]. (18095625)
2007
33
Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. (17005651)
2006
34
hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. (16950395)
2006
35
ELISpot assay as a sensitive tool to detect cellular immunity following influenza vaccination in kidney transplant recipients. (16631409)
2006
36
Cell surface expression of FcgammaRI (CD64) on neutrophils and monocytes in patients with influenza A, with and without complications. (16308225)
2005
37
Influenza A virus protein PB1-F2: synthesis and characterization of the biologically active full length protein and related peptides. (15641124)
2005
38
Decreasing prevalence of beta-lactamase production among respiratory tract isolates of Haemophilus influenzae in the United States. (15917574)
2005
39
Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. (14985487)
2004
40
Drift in the nucleoprotein gene of swine influenza virus (H1N1) causing respiratory disease in pigs. (12206303)
2002
41
Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. (12359784)
2002
42
Release of macrophage migration inhibitory factor and CXCL8/interleukin-8 from lung epithelial cells rendered necrotic by influenza A virus infection. (12186913)
2002
43
X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. (11562490)
2001
44
An analysis of the role of neuraminidase in the receptor-binding activity of influenza B virus: the inhibitory effect of Zanamivir on haemadsorption. (10580059)
1999
45
Effect of sequential porcine reproductive and respiratory syndrome and swine influenza on the growth and performance of finishing pigs. (7998380)
1994
46
Immunogenicity and adverse reactions of influenza vaccination in elderly patients given acetaminophen or placebo. (15566726)
1993
47
Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes. (1532050)
1992
48
A decision analysis approach to the swine influenza vaccination decision for an individual. (6243731)
1980
49
Transplacental transmission and neonatal infection with swine influenza virus (Hsw1N1) in swine. (575027)
1979
50
In vitro adsorption of influenza and parotitis viruses by the nervous substance of the chick embryo]. (13578421)
1958

Genetic Variations for Influenza

Expression for genes affiliated with Influenza

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Influenza

Search GEO for disease gene expression data for Influenza.

Pathways for genes affiliated with Influenza

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Influenza

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Influenza according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1cysteine4512.0SFTPD, IFNG, IFNB1, NEU1, XDH, PTPN11
2lipid4511.9SFTPD, IFNB1, XDH, CXCL10, MX1, PTPN11
3ifn-alpha4511.7IFNG, IFNB1, CXCL10, MX1, PTPN11
4rantes4511.7PTPN11, MX1, CXCL10, IFNB1, IFNG
5thymidine45 2412.6PTPN11, CXCL10, IFNB1, IFNG, SFTPD
6adenylate4511.5IFNB1, IVNS1ABP, CXCL10, FURIN, CPSF4
72,5-oligoadenylate4511.5IFNG, IFNB1, CXCL10, MX1
8poly(i-c)4511.5MX1, CXCL10, IFNB1, IFNG
9neopterin4511.5IFNG, IFNB1, CXCL10, MX1
10ribavirin45 50 1113.4MX1, NEU1, IFNG
11betaseron4511.4MX1, IFNB1, IFNG
12acyclovir45 1112.3IFNG, IFNB1, NEU1
13imiquimod45 29 60 1114.3MX1, IFNB1, IFNG
14con a4511.3IFNG, NEU1, FURIN
15fluticasone propionate45 50 60 1114.3CXCL10, IFNB1, IFNG
16gsno4511.3IFNG, XDH, CXCL10
17polyinosinic-polycytidylic acid4511.3CXCL10, IFNB1, IFNG
18il 104511.3IFNG, IFNB1, CXCL10
19polysaccharide4511.3SFTPD, IFNB1, PDPN, NEU1
20tarc4511.3CXCL10, IFNB1, IFNG
21ccl345 2912.3IFNG, IFNB1, CXCL10
22allergens4511.2CXCL10, IFNG, SFTPD
23cycloheximide4511.2MX1, CXCL10, IFNB1
24rebif4511.2MX1, IFNB1
25carboplatin45 50 1113.2IFNG, IFNB1, XDH
26tetracycline45 1112.1FURIN, PTPN11, IFNB1
27avonex4511.1MX1, IFNB1
28histamine45 29 2413.1SFTPD, IFNG, NEU1, CXCL10
29sodium stibogluconate45 1112.1IFNG, PTPN11
30mezerein4510.9IFNB1, IFNG
31kynurenine4510.9IFNB1, IFNG
32monosaccharide4510.8NEU1, SFTPD
33d penicillamine4510.7XDH, IFNG
34glatiramer acetate45 1111.5IFNB1, IFNG

GO Terms for genes affiliated with Influenza

Sources:
16Gene Ontology
See all sources

Biological processes related to Influenza according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922111.7IFNG, IFITM3, IFNB1, MX1, MX2, PTPN11
2type I interferon-mediated signaling pathwayGO:06033711.5IFITM3, IFNB1, PTPN11, MX2, MX1
3response to virusGO:00961511.5MX1, IVNS1ABP, IFNB1, IFITM3, IFNG
4defense response to virusGO:05160711.5IFNG, IFITM3, IFNB1, CXCL10, MX1
5negative regulation of viral genome replicationGO:04507111.1IFITM3, IFNB1, MX1
6positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.9IFNG, IFNB1
7negative regulation of viral transcriptionGO:03289710.9IFNB1, IFITM3
8negative regulation of viral entry into host cellGO:04659710.8IFITM3, IFNB1
9adaptive immune responseGO:00225010.8IFNG, IFNB1
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IFNG, FURIN
11regulation of interferon-gamma-mediated signaling pathwayGO:06033410.5PTPN11, IFNG

Products for genes affiliated with Influenza

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Influenza

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet