Influenza (FLU) malady

Infectious diseases, Respiratory diseases categories

Summaries for Influenza

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MedlinePlus:33 Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. most people with the flu recover on their own without medical care. people with mild cases of the flu should stay home and avoid contact with others, except to get medical care. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. the main way to keep from getting the flu is to get a yearly flu vaccine. good hygiene, including hand washing, can also help. nih: national institute of allergy and infectious diseases

MalaCards based summary: Influenza, also known as influenza with non-respiratory manifestation, is related to pneumonia and hepatitis, and has symptoms including chills, fever and sore throat. An important gene associated with Influenza is IFITM3 (interferon induced transmembrane protein 3), and among its related pathways are Immune response Bacterial infections in normal airways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drug influenza neuraminidase inhibitor [epc] and the compounds rebif and avonex have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, t cells and lung, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:9 A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

Wikipedia:64 Influenza, commonly known as \"the flu\", is an infectious disease of birds and mammals caused by RNA... more...

Aliases & Classifications for Influenza

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Influenza, Aliases & Descriptions:

Name: Influenza 9 11 44 61
Influenza with Non-Respiratory Manifestation 9 61
Influenza with Other Manifestations 9 61
Flu 9 33
Influenza with Other Manifestations Nos 9


Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases

External Ids:

Disease Ontology9 DOID:8469
ICD9CM28 487
NCIt39 C53482
MeSH34 D007251

Related Diseases for Influenza

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Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 442)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7XDH, SFTPD, NEU1, CXCL10
2hepatitis31.5IFNB1, CXCL10, XDH
3newcastle disease31.4IVNS1ABP, NEU1, CXCL10, IFNB1
4respiratory failure31.2CXCL10, NEU1, SFTPD
5encephalitis31.1MX1, CXCL10
6hemophagocytic lymphohistiocytosis31.0IFNB1, MX1
7arthritis31.0IVNS1ABP, PTPN11, CXCL10, MX1
8sepsis30.8XDH, FURIN, SFTPD, NEU1
9chronic obstructive pulmonary disease30.6XDH, SFTPD, CXCL10
10herpes simplex30.6MX1, IFNB1, CXCL10, NEU1
11systemic lupus erythematosus30.6PTPN11, CXCL10, IFNB1, MX1
12malaria30.6NEU1, XDH
13asthma30.6XDH, SFTPD, NEU1, CXCL10, IFNB1, MX1
14rheumatoid arthritis30.5IVNS1ABP, SFTPD, PTPN11, CXCL10, IFNB1
15rift valley fever30.4MX1
16japanese encephalitis30.4PTPN11, IVNS1ABP
17venezuelan equine encephalitis30.3FURIN
18kaposi's sarcoma30.2CXCL10, IFNB1, PDPN
19hepatitis c30.2CXCL10, IFNB1, MX1
20sarcoidosis30.1HLA-S, SFTPD, CXCL10
21multiple sclerosis30.1XDH, CXCL10, IFNB1, MX1
22adenocarcinoma29.9FURIN, SFTPD, CXCL10, IFNB1, MAGEA3, PDPN
23melanoma29.7DDX58, XDH, PTPN11, NEU1, CXCL10, IFNB1
24avian influenza11.2
25swine influenza11.2
26haemophilus influenzae11.1
32hepatitis b10.6
33otitis media10.5
34viral pneumonia10.5
36dengue hemorrhagic fever10.4IVNS1ABP, PTPN11
39egg allergy10.4
40hydrops fetalis10.4PTPN11, NEU1
43acute disseminated encephalomyelitis10.4
44atrophic gastritis10.4XDH, PTPN11
46relapsing-remitting multiple sclerosis10.4MX1, IFNB1
49guillain-barre syndrome10.3

Graphical network of the top 20 diseases related to Influenza:

Diseases related to influenza

Symptoms for Influenza

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 9 (show all 8)
  • chills
  • fever
  • sore throat
  • runny nose
  • muscle pains
  • severe headache
  • cough
  • weakness

Drugs & Therapeutics for Influenza

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Drug clinical trials:

Search ClinicalTrials for Influenza

Search NIH Clinical Center for Influenza

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Influenza

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Anatomical Context for Influenza

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MalaCards organs/tissues related to Influenza:

T cells, Lung, Testes, Monocytes, Neutrophil, Heart, Colon, B cells, Brain, Nk cells, Bone, Kidney, Thyroid, Tonsil, Bone marrow, Endothelial, Spinal cord, Liver, Prostate, Eye, Skin, Myeloid, Trachea

FMA organs/tissues related to Influenza:

Respiratory tract

Animal Models for Influenza or affiliated genes

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MGI Mouse Phenotypes related to Influenza:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.9XDH, IVNS1ABP, SFTPD, PTPN11, NEU1, CXCL10
2MP:00053978.8DDX58, FURIN, SFTPD, PTPN11, NEU1, CXCL10
3MP:00053878.7MX2, DDX58, XDH, FURIN, SFTPD, PTPN11

Publications for Influenza

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Articles related to Influenza:

(show top 50)    (show all 3680)
Automated influenza-like illness reporting-an efficient adjunct to traditional sentinel surveillance. (24381360)
Risk of Fever After Pediatric Trivalent Inactivated Influenza Vaccine and 13-Valent Pneumococcal Conjugate Vaccine. (24395025)
Commentary on Zhang J, While AE and Norman IJ (2012) Development and testing of an instrument to assess nurses' knowledge, risk perception, health beliefs and behaviours related to influenza vaccination. Journal of Clinical Nursing 21, 2636-2646. (24313943)
Haemophilus haemolyticus is infrequently misidentified as Haemophilus influenzae in diagnostic specimens in Australia. (25266675)
Exposure to avian influenza H7N9 in farms and wet markets. (23664058)
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). (22819125)
Pathogenicity of an H5N1 highly pathogenic avian influenza virus isolated in the 2010-2011 winter in Japan to mandarin ducks. (23318574)
Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function. (23548901)
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
Genesis and genetic constellations of swine influenza viruses in Thailand. (24095146)
Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers. (23080288)
Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008. (23967241)
Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus. (23265247)
Complete Genome Sequence of Encapsulated Haemophilus influenzae Type f KR494, an Invasive Isolate That Caused Necrotizing Myositis. (24092777)
Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins. (22318733)
YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules. (22855482)
Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. (22851708)
Guillain-BarrAc syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: case report and review of the literature. (22000408)
Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae. (22298528)
Risk factors for avian influenza and Newcastle disease in smallholder farming systems, Madagascar highlands. (22130311)
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
Expression of myeloperoxidase in swine influenza virus (SIV)-infected neutrophils in lungs from pigs experimentally infected with SIV subtype H1N2. (21688042)
Experimental design to optimize an Haemophilus influenzae type b conjugate vaccine made with hydrazide-derivatized tetanus toxoid. (21850577)
Cell-mediated immune responses to inactivated trivalent influenza-vaccination are decreased in patients with common variable immunodeficiency. (21889412)
Isolation and Phylogenetic Analysis of H1N1 Swine Influenza Virus from Sick Pigs in Southern China. (23637505)
Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling. (21288362)
Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus. (20392922)
Viral encephalitis associated with pandemic 2009 (H1N1) influenza A. (22767664)
Differences in serum cytokine levels between influenza virus A and B infections in children. (19497758)
Swine influenza: nephrologist's perspective. (19617670)
Expression of mouse beta-defensin-3 in MDCK cells and its anti-influenza-virus activity. (19301094)
Swine influenza: then and now. (19494369)
The antibody responses to swine influenza virus (SIV) recombinant matrix 1 (rM1), matrix 2 (M2), and hemagglutinin (HA) proteins in pigs with different SIV exposure. (17719187)
The role of p38 mitogen activated protein kinase in the inflammatory response of human monocytes infected with nontypeable Haemophilus influenzae]. (18953958)
Outcome of influenza infection managed with oseltamivir in lung transplant recipients. (18342750)
Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus. (16585542)
p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. (16051807)
The structure and receptor binding properties of the 1918 influenza hemagglutinin. (14764886)
Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir. (12821478)
Immune reactivity against a novel HLA-A3-restricted influenza virus peptide identified by predictive algorithms and interferon-gamma quantitative PCR. (12514428)
Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees. (12141967)
Management of influenza in patients with asthma or chronic obstructive pulmonary disease. (11770690)
The 1-127 HA2 construct of influenza virus hemagglutinin induces cell-cell hemifusion. (11444985)
Identification of a 374 amino acid protein encoded by RNA segment 6 of influenza C virus. (9747730)
Regulation of HLA class I and II expression by interferons and influenza A virus in human peripheral blood mononuclear cells. (9301532)
A strategy for theoretical binding constant, Ki, calculations for neuraminidase aromatic inhibitors designed on the basis of the active site structure of influenza virus neuraminidase. (8592707)
In vitro activation of human T lymphocytes by Haemophilus influenzae type b capsular polysaccharides. (1346727)
Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus. (1321288)
Purulent salpingitis and intra-uterine contraceptive device-related infection due to Haemophilus influenzae. (2002228)
Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (2161946)

Variations for Influenza

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Expression for genes affiliated with Influenza

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2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Influenza patients vs. healthy controls: 31 (show all 400)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1IFI27interferon, alpha-inducible protein 27Blood+6.130.000
3KCTD14potassium channel tetramerization domain containing 14Blood+5.450.000
4HESX1HESX homeobox 1Blood+4.330.000
5CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrialBlood+4.320.000
6CCNA1cyclin A1Blood+4.260.000
7METTL7Bmethyltransferase like 7BBlood+4.120.000
8C1QCcomplement component 1, q subcomponent, C chainBlood+4.110.000
9OLFM4olfactomedin 4Blood+3.990.000
10SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesinBlood+3.980.000
11OLFM1olfactomedin 1Blood-3.920.000
12RSAD2radical S-adenosyl methionine domain containing 2Blood+3.860.000
13GPR42G protein-coupled receptor 42 (gene/pseudogene)Blood+3.850.000
14RNASE1ribonuclease, RNase A family, 1 (pancreatic)Blood+3.830.000
15CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)Blood+3.800.000
16KCNE1potassium voltage-gated channel, Isk-related family, member 1Blood+3.730.000
17OAS32'-5'-oligoadenylate synthetase 3, 100kDaBlood+3.700.000
18TMEM119transmembrane protein 119Blood+3.660.000
19DNAAF1dynein, axonemal, assembly factor 1Blood+3.540.000
21PRSS33protease, serine, 33Blood-3.420.000
22IFI44Linterferon-induced protein 44-likeBlood+3.420.000
23PPARGperoxisome proliferator-activated receptor gammaBlood+3.380.000
24PID1phosphotyrosine interaction domain containing 1Blood-3.370.000
25SLC26A8solute carrier family 26 (anion exchanger), member 8Blood+3.370.000
26IFITM4Pinterferon induced transmembrane protein 4 pseudogeneBlood+3.310.000
27CNTNAP2contactin associated protein-like 2Blood-3.300.000
28PTGDR2prostaglandin D2 receptor 2Blood-3.280.000
29IFIT1interferon-induced protein with tetratricopeptide repeats 1Blood+3.280.000
30GPR84G protein-coupled receptor 84Blood+3.250.000
31CACNG6calcium channel, voltage-dependent, gamma subunit 6Blood-3.220.000
32IL27interleukin 27Blood+3.210.000
33SYN2synapsin IIBlood+3.200.000
34OAS12'-5'-oligoadenylate synthetase 1, 40/46kDaBlood+3.190.000
35MATKmegakaryocyte-associated tyrosine kinaseBlood-3.180.000
36HIST1H4Dhistone cluster 1, H4dBlood+3.160.000
37OLIG2oligodendrocyte lineage transcription factor 2Blood-3.150.000
38ISG15ISG15 ubiquitin-like modifierBlood+3.110.000
39IFIT3interferon-induced protein with tetratricopeptide repeats 3Blood+3.090.000
40EXOC3L1exocyst complex component 3-like 1Blood+3.090.000
41RSPH9radial spoke head 9 homolog (Chlamydomonas)Blood+3.080.000
42CD177CD177 moleculeBlood+3.040.000
43TCN2transcobalamin IIBlood+3.030.000
44IFI44interferon-induced protein 44Blood+3.030.000
45PLSCR1phospholipid scramblase 1Blood+3.010.000
46ARG1arginase 1Blood+2.970.001
47SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1Blood+2.970.000
48MMP8matrix metallopeptidase 8 (neutrophil collagenase)Blood+2.960.001
49OASL2'-5'-oligoadenylate synthetase-likeBlood+2.950.000
50MT1Gmetallothionein 1GBlood+2.930.000
51USP41ubiquitin specific peptidase 41Blood+2.930.000
52KRT86keratin 86Blood-2.920.000
53C1QBcomplement component 1, q subcomponent, B chainBlood+2.880.000
54FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideBlood-2.860.000
55ZCCHC2zinc finger, CCHC domain containing 2Blood+2.850.000
57SLC51Asolute carrier family 51, alpha subunitBlood+2.840.000
58HIST1H1Thistone cluster 1, H1tBlood+2.830.000
59TDRD9tudor domain containing 9Blood+2.830.000
60MS4A4Amembrane-spanning 4-domains, subfamily A, member 4ABlood+2.820.000
61PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)Blood+2.820.000
62BEX1brain expressed, X-linked 1Blood+2.780.001
63PNPLA1patatin-like phospholipase domain containing 1Blood+2.780.000
64LRRN1leucine rich repeat neuronal 1Blood+2.750.000
65ETV7ets variant 7Blood+2.730.000
67CCL8chemokine (C-C motif) ligand 8Blood+2.720.007
68DEFB1defensin, beta 1Blood+2.700.000
69ZDHHC1zinc finger, DHHC-type containing 1Blood-2.690.000
70TNFAIP6tumor necrosis factor, alpha-induced protein 6Blood+2.680.000
71LAMP3lysosomal-associated membrane protein 3Blood+2.670.000
72SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Blood+2.660.000
73TRIM6tripartite motif containing 6Blood+2.650.000
74CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Blood+2.620.005
75IFITM3interferon induced transmembrane protein 3Blood+2.620.000
76ANXA3annexin A3Blood+2.610.004
77PRTN3proteinase 3Blood+2.610.009
78ADORA3adenosine A3 receptorBlood+2.600.001
79SEPT4septin 4Blood+2.600.000
80MMP28matrix metallopeptidase 28Blood-2.580.000
81RNASE3ribonuclease, RNase A family, 3Blood+2.560.007
82TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)Blood+2.550.001
83PNMA3paraneoplastic Ma antigen 3Blood-2.540.000
84CLEC5AC-type lectin domain family 5, member ABlood+2.540.000
86ZNF540zinc finger protein 540Blood-2.520.000
87ANKRD22ankyrin repeat domain 22Blood+2.490.000
88ANKRD34Bankyrin repeat domain 34BBlood+2.490.000
89C3AR1complement component 3a receptor 1Blood+2.490.000
90HAGHLhydroxyacylglutathione hydrolase-likeBlood-2.480.000
91COL17A1collagen, type XVII, alpha 1Blood+2.480.003
92ZDHHC19zinc finger, DHHC-type containing 19Blood+2.470.005
93IL18R1interleukin 18 receptor 1Blood+2.450.000
94FFAR3free fatty acid receptor 3Blood+2.450.001
95AXLAXL receptor tyrosine kinaseBlood+2.450.003
96CACNA2D3calcium channel, voltage-dependent, alpha 2/delta subunit 3Blood-2.440.000
97NRCAMneuronal cell adhesion moleculeBlood-2.430.002
98IFI6interferon, alpha-inducible protein 6Blood+2.430.000
99FOXC1forkhead box C1Blood+2.430.002
100NAIPNLR family, apoptosis inhibitory proteinBlood+2.430.000
101HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5Blood+2.420.000
102NECAB1N-terminal EF-hand calcium binding protein 1Blood+2.420.000
103C19orf59chromosome 19 open reading frame 59Blood+2.420.000
104HIST2H2ABhistone cluster 2, H2abBlood+2.410.001
105ARHGAP23Rho GTPase activating protein 23Blood+2.400.000
106HNRNPA1P10heterogeneous nuclear ribonucleoprotein A1 pseudogene 10Blood-2.400.000
107GRAPGRB2-related adaptor proteinBlood-2.400.000
108FRMD3FERM domain containing 3Blood+2.380.000
109CRIP2cysteine-rich protein 2Blood-2.370.003
110XAF1XIAP associated factor 1Blood+2.360.000
111EXOGendo/exonuclease (5'-3'), endonuclease G-likeBlood+2.350.000
112IRF7interferon regulatory factor 7Blood+2.340.000
113FCGR1AFc fragment of IgG, high affinity Ia, receptor (CD64)Blood+2.340.000
114CR1complement component (3b/4b) receptor 1 (Knops blood group)Blood+2.340.001
115HDChistidine decarboxylaseBlood-2.340.004
116SIGLEC5sialic acid binding Ig-like lectin 5Blood+2.330.000
117EMR4Pegf-like module containing, mucin-like, hormone receptor-like 4 pseudogeneBlood-2.330.001
118GPR141G protein-coupled receptor 141Blood+2.330.000
119CLEC4DC-type lectin domain family 4, member DBlood+2.320.004
120SP8Sp8 transcription factorBlood+2.320.001
121RGL1ral guanine nucleotide dissociation stimulator-like 1Blood+2.320.000
122FCRL6Fc receptor-like 6Blood-2.320.005
123LCN2lipocalin 2Blood+2.320.000
124FAM90A1family with sequence similarity 90, member A1Blood+2.320.001
125PTGR1prostaglandin reductase 1Blood+2.310.000
126OAS22'-5'-oligoadenylate synthetase 2, 69/71kDaBlood+2.310.010
127CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Blood+2.300.000
128KLRC1killer cell lectin-like receptor subfamily C, member 1Blood-2.300.002
129HIST1H2AMhistone cluster 1, H2amBlood+2.300.001
130ZNF683zinc finger protein 683Blood-2.290.000
131PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2Blood+2.280.019
132VWCEvon Willebrand factor C and EGF domainsBlood-2.280.036
133RPSAribosomal protein SABlood-2.270.002
134GPR68G protein-coupled receptor 68Blood-2.270.000
135BATF2basic leucine zipper transcription factor, ATF-like 2Blood+2.270.000
136GTSF1Lgametocyte specific factor 1-likeBlood-2.260.000
137HIST1H2BDhistone cluster 1, H2bdBlood+2.260.000
138HSD17B13hydroxysteroid (17-beta) dehydrogenase 13Blood+2.260.001
139LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6Blood+2.260.000
140HPD4-hydroxyphenylpyruvate dioxygenaseBlood+2.250.000
141KCNG1potassium voltage-gated channel, subfamily G, member 1Blood-2.230.001
142HIST1H4Hhistone cluster 1, H4hBlood+2.230.000
143FHITfragile histidine triadBlood-2.230.001
144ABCA13ATP-binding cassette, sub-family A (ABC1), member 13Blood+2.220.003
145NTNG2netrin G2Blood+2.220.000
146BPIbactericidal/permeability-increasing proteinBlood+2.220.001
147NOVnephroblastoma overexpressedBlood-2.220.002
148CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunitBlood+2.220.005
149AZU1azurocidin 1Blood+2.220.009
150BMXBMX non-receptor tyrosine kinaseBlood+2.210.011
151PRSS23protease, serine, 23Blood-2.210.003
152IL23Ainterleukin 23, alpha subunit p19Blood-2.200.004
153CLCCharcot-Leyden crystal galectinBlood-2.200.004
154PTGDRprostaglandin D2 receptor (DP)Blood-2.200.003
155MAP2K6mitogen-activated protein kinase kinase 6Blood+2.190.000
156HIST1H2BFhistone cluster 1, H2bfBlood+2.190.001
157FGF13fibroblast growth factor 13Blood+2.190.008
158MSR1macrophage scavenger receptor 1Blood+2.180.003
159RNASE2ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)Blood+2.180.001
160TMEM8Btransmembrane protein 8BBlood-2.180.001
161FAN1FANCD2/FANCI-associated nuclease 1Blood-2.170.002
162MAKmale germ cell-associated kinaseBlood+2.170.029
163IL1RNinterleukin 1 receptor antagonistBlood+2.170.000
164KLRB1killer cell lectin-like receptor subfamily B, member 1Blood-2.170.000
165LIN7Alin-7 homolog A (C. elegans)Blood+2.170.000
166MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Blood+2.170.002
167TRIM14tripartite motif containing 14Blood+2.160.004
168SIGLEC17Psialic acid binding Ig-like lectin 17, pseudogeneBlood-2.160.001
169NELL1NEL-like 1 (chicken)Blood+2.150.000
170LTC4Sleukotriene C4 synthaseBlood-2.140.011
171PMP22peripheral myelin protein 22Blood-2.140.013
172PIWIL4piwi-like RNA-mediated gene silencing 4Blood+2.130.002
173DBNDD1dysbindin (dystrobrevin binding protein 1) domain containing 1Blood-2.130.008
174MAOAmonoamine oxidase ABlood+2.120.025
175CNR2cannabinoid receptor 2 (macrophage)Blood-2.120.002
176C10orf10chromosome 10 open reading frame 10Blood+2.120.002
177FXYD2FXYD domain containing ion transport regulator 2Blood-2.120.002
178FGD4FYVE, RhoGEF and PH domain containing 4Blood+2.110.003
179SAMD9Lsterile alpha motif domain containing 9-likeBlood+2.110.000
180CCDC65coiled-coil domain containing 65Blood-2.110.014
181NEXNnexilin (F actin binding protein)Blood+2.110.000
182CASP5caspase 5, apoptosis-related cysteine peptidaseBlood+2.100.008
183CD1ECD1e moleculeBlood-2.100.001
184TPCN1two pore segment channel 1Blood-2.100.002
185CPEB4cytoplasmic polyadenylation element binding protein 4Blood+2.090.009
186CARD17caspase recruitment domain family, member 17Blood+2.080.010
187EMP1epithelial membrane protein 1Blood+2.070.002
188H1F0H1 histone family, member 0Blood+2.070.000
189ATP6V1G2ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2Blood+2.060.005
191ALOX15arachidonate 15-lipoxygenaseBlood-2.060.025
192DEFA4defensin, alpha 4, corticostatinBlood+2.060.028
193WSB1WD repeat and SOCS box containing 1Blood+2.060.000
194KRT75keratin 75Blood+2.050.005
195EPHA4EPH receptor A4Blood-2.050.017
196TLR2toll-like receptor 2Blood+2.050.001
197HIST1H3Dhistone cluster 1, H3dBlood+2.040.000
198CERKLceramide kinase-likeBlood-2.040.023
199ZBTB46zinc finger and BTB domain containing 46Blood-2.030.004
200PASKPAS domain containing serine/threonine kinaseBlood-2.030.001
201ACOT11acyl-CoA thioesterase 11Blood-2.030.004
202TPPP3tubulin polymerization-promoting protein family member 3Blood-2.030.005
204HIST2H2AChistone cluster 2, H2acBlood+2.030.000
205OLAHoleoyl-ACP hydrolaseBlood+2.020.017
206MGST1microsomal glutathione S-transferase 1Blood+2.010.016
207MKRN3makorin ring finger protein 3Blood-2.010.007
208CLEC1BC-type lectin domain family 1, member BBlood+2.010.000
209EPSTI1epithelial stromal interaction 1 (breast)Blood+2.010.000
210LY6Elymphocyte antigen 6 complex, locus EBlood+2.010.001
211CABP4calcium binding protein 4Blood-2.010.002
212MDKmidkine (neurite growth-promoting factor 2)Blood+2.000.003
213PTPRNprotein tyrosine phosphatase, receptor type, NBlood+2.000.017
214ZBP1Z-DNA binding protein 1Blood+2.000.000
215RABL2ARAB, member of RAS oncogene family-like 2ABlood-2.000.010
216PCOLCE2procollagen C-endopeptidase enhancer 2Blood+1.990.027
217FAM20Afamily with sequence similarity 20, member ABlood+1.990.008
218RPH3Arabphilin 3A homolog (mouse)Blood+1.990.018
219IFIT2interferon-induced protein with tetratricopeptide repeats 2Blood+1.990.001
220AIM2absent in melanoma 2Blood+1.990.001
221QTRT1queuine tRNA-ribosyltransferase 1Blood-1.980.004
222HIST2H2AA3histone cluster 2, H2aa3Blood+1.980.000
223DEFA3defensin, alpha 3, neutrophil-specificBlood+1.980.020
224FCARFc fragment of IgA, receptor forBlood+1.980.002
225TCF7transcription factor 7 (T-cell specific, HMG-box)Blood-1.980.011
226HSF5heat shock transcription factor family member 5Blood-1.980.030
227ACOX2acyl-CoA oxidase 2, branched chainBlood+1.980.032
228CFBcomplement factor BBlood+1.980.006
229TUFT1tuftelin 1Blood+1.970.006
230RTN4Rreticulon 4 receptorBlood-1.970.002
231LY6G6Dlymphocyte antigen 6 complex, locus G6DBlood+1.970.007
232ZC3H12Bzinc finger CCCH-type containing 12BBlood-1.970.009
233IL37interleukin 37Blood+1.970.000
234GNG3guanine nucleotide binding protein (G protein), gamma 3Blood-1.970.008
235SIRPGsignal-regulatory protein gammaBlood-1.960.010
236FSD1Lfibronectin type III and SPRY domain containing 1-likeBlood+1.960.014
237NMT2N-myristoyltransferase 2Blood-1.960.007
238EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 2Blood+1.960.000
239RAD1RAD1 homolog (S. pombe)Blood-1.950.029
240LONRF3LON peptidase N-terminal domain and ring finger 3Blood+1.950.016
241KREMEN1kringle containing transmembrane protein 1Blood+1.950.015
242THAP4THAP domain containing 4Blood-1.940.006
243RN7SKRNA, 7SK small nuclearBlood+1.940.022
244GDF15growth differentiation factor 15Blood+1.940.018
245RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Blood+1.930.012
246CD244CD244 molecule, natural killer cell receptor 2B4Blood-1.930.000
247MUC1mucin 1, cell surface associatedBlood+1.930.014
248CPA3carboxypeptidase A3 (mast cell)Blood-1.930.032
249SYT17synaptotagmin XVIIBlood-1.920.008
250TC2Ntandem C2 domains, nuclearBlood-1.920.017
251C16orf74chromosome 16 open reading frame 74Blood-1.920.006
252CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 19Blood+1.920.008
253CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunitBlood+1.920.039
254GYLTL1Bglycosyltransferase-like 1BBlood-1.920.008
255OR52K2olfactory receptor, family 52, subfamily K, member 2Blood+1.920.017
256BAMBIBMP and activin membrane-bound inhibitorBlood+1.910.039
257H2AFJH2A histone family, member JBlood+1.910.000
258MT2Ametallothionein 2ABlood+1.910.003
259PKD2L1polycystic kidney disease 2-like 1Blood+1.910.026
260NBL1neuroblastoma 1, DAN family BMP antagonistBlood-1.910.006
261UPB1ureidopropionase, betaBlood+1.910.020
263SPNS3spinster homolog 3 (Drosophila)Blood-1.900.006
264TCN1transcobalamin I (vitamin B12 binding protein, R binder family)Blood+1.900.002
266IGF2BP3insulin-like growth factor 2 mRNA binding protein 3Blood+1.900.006
267MERTKc-mer proto-oncogene tyrosine kinaseBlood+1.900.006
268RABEP2rabaptin, RAB GTPase binding effector protein 2Blood-1.900.013
269VNN1vanin 1Blood+1.900.006
270TOXthymocyte selection-associated high mobility group boxBlood-1.890.014
271NLE1notchless homolog 1 (Drosophila)Blood-1.890.003
272PILRBpaired immunoglobin-like type 2 receptor betaBlood-1.890.013
273LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseBlood-1.890.005
274CLEC4EC-type lectin domain family 4, member EBlood+1.890.011
275MIIPmigration and invasion inhibitory proteinBlood+1.890.006
276ABCA1ATP-binding cassette, sub-family A (ABC1), member 1Blood+1.890.000
277KIF1Bkinesin family member 1BBlood+1.880.001
278ELANEelastase, neutrophil expressedBlood+1.880.031
279FCGBPFc fragment of IgG binding proteinBlood-1.880.004
280SNORD21small nucleolar RNA, C/D box 21Blood-1.870.026
281VPS13Bvacuolar protein sorting 13 homolog B (yeast)Blood+1.870.009
282LYPD2LY6/PLAUR domain containing 2Blood-1.870.033
283SLPIsecretory leukocyte peptidase inhibitorBlood+1.870.043
284TDP1tyrosyl-DNA phosphodiesterase 1Blood-1.870.009
285DNTTDNA nucleotidylexotransferaseBlood-1.870.024
286OLR1oxidized low density lipoprotein (lectin-like) receptor 1Blood+1.860.032
287TRAF5TNF receptor-associated factor 5Blood-1.860.036
288PARP9poly (ADP-ribose) polymerase family, member 9Blood+1.860.000
289VPREB1pre-B lymphocyte 1Blood-1.860.043
290DSC1desmocollin 1Blood-1.840.029
291TOP1MTtopoisomerase (DNA) I, mitochondrialBlood-1.830.021
292TELO2telomere maintenance 2Blood-1.830.007
293MYBBP1AMYB binding protein (P160) 1aBlood-1.830.027
294MS4A1membrane-spanning 4-domains, subfamily A, member 1Blood-1.830.024
295GZMKgranzyme K (granzyme 3; tryptase II)Blood-1.820.002
296FMNL3formin-like 3Blood-1.820.006
297PHLDB3pleckstrin homology-like domain, family B, member 3Blood-1.810.030
298TUBGCP6tubulin, gamma complex associated protein 6Blood-1.810.019
299TNFRSF25tumor necrosis factor receptor superfamily, member 25Blood-1.810.003
300EEF1A2eukaryotic translation elongation factor 1 alpha 2Blood-1.800.026
301ADCarginine decarboxylaseBlood-1.790.011
302GATA2GATA binding protein 2Blood-1.790.019
303ANO9anoctamin 9Blood-1.780.019
304LCATlecithin-cholesterol acyltransferaseBlood-1.780.005
305NELL2NEL-like 2 (chicken)Blood-1.780.004
306HTR3A5-hydroxytryptamine (serotonin) receptor 3A, ionotropicBlood-1.770.012
307LEPREL1leprecan-like 1Blood-1.770.029
308RAB15RAB15, member RAS oncogene familyBlood-1.760.028
309FAM102Afamily with sequence similarity 102, member ABlood-1.760.006
310CD200CD200 moleculeBlood-1.760.033
311ACTG2actin, gamma 2, smooth muscle, entericBlood-1.760.017
312SELMselenoprotein MBlood-1.750.040
313SFTPDsurfactant protein DBlood-1.750.032
314RASSF1Ras association (RalGDS/AF-6) domain family member 1Blood-1.750.012
315FCRL3Fc receptor-like 3Blood-1.750.006
316P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)Blood-1.750.016
317HNRNPA1P4heterogeneous nuclear ribonucleoprotein A1 pseudogene 4Blood-1.750.006
318CYP4F22cytochrome P450, family 4, subfamily F, polypeptide 22Blood-1.750.045
319ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1Blood-1.750.026
320RPL14ribosomal protein L14Blood-1.750.001
322EDARectodysplasin A receptorBlood-1.750.023
323DFNB59deafness, autosomal recessive 59Blood-1.740.029
324SEH1LSEH1-like (S. cerevisiae)Blood-1.740.044
325RLTPRRGD motif, leucine rich repeats, tropomodulin domain and proline-rich containingBlood-1.740.028
326RYR1ryanodine receptor 1 (skeletal)Blood-1.740.011
327GOLGA7Bgolgin A7 family, member BBlood-1.740.017
328LBHlimb bud and heart developmentBlood-1.730.017
329LRRC56leucine rich repeat containing 56Blood-1.730.036
330ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix proteinBlood-1.730.000
331SIGLEC6sialic acid binding Ig-like lectin 6Blood-1.720.024
332KLRF1killer cell lectin-like receptor subfamily F, member 1Blood-1.710.040
333RTN1reticulon 1Blood-1.710.003
334TBC1D4TBC1 domain family, member 4Blood-1.710.025
335CTGFconnective tissue growth factorBlood-1.700.015
336ADAM28ADAM metallopeptidase domain 28Blood-1.690.030
337CAPN5calpain 5Blood-1.690.019
338CRHR1-IT1CRHR1 intronic transcript 1 (non-protein coding)Blood-1.690.032
339SPATC1Lspermatogenesis and centriole associated 1-likeBlood-1.690.047
340CD1ACD1a moleculeBlood-1.680.035
341CCDC7coiled-coil domain containing 7Blood-1.670.028
342CHTF18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)Blood-1.660.046
343SFT2D3SFT2 domain containing 3Blood-1.660.024
344MRPL43mitochondrial ribosomal protein L43Blood-1.660.026
345SIGLEC8sialic acid binding Ig-like lectin 8Blood-1.660.039
346DLEC1deleted in lung and esophageal cancer 1Blood-1.660.007
347RAB11FIP4RAB11 family interacting protein 4 (class II)Blood-1.660.026
348CD160CD160 moleculeBlood-1.660.019
349LOC644172mitogen-activated protein kinase 8 interacting protein 1 pseudogeneBlood-1.650.006
350ABCF2ATP-binding cassette, sub-family F (GCN20), member 2Blood-1.650.048
351FCER2Fc fragment of IgE, low affinity II, receptor for (CD23)Blood-1.640.009
352C11orf80chromosome 11 open reading frame 80Blood-1.640.020
353TMEM128transmembrane protein 128Blood-1.630.044
354CD8BCD8b moleculeBlood-1.620.036
355RPL10Aribosomal protein L10aBlood-1.620.005
356SMC1Astructural maintenance of chromosomes 1ABlood-1.610.038
357PMEPA1prostate transmembrane protein, androgen induced 1Blood-1.610.023
358SNRNP70small nuclear ribonucleoprotein 70kDa (U1)Blood-1.610.034
359FGFBP2fibroblast growth factor binding protein 2Blood-1.610.043
360PARM1prostate androgen-regulated mucin-like protein 1Blood-1.610.045
361DCDC5doublecortin domain containing 5Blood-1.610.033
362CRTAPcartilage associated proteinBlood-1.610.022
363RAP2BRAP2B, member of RAS oncogene familyBlood-1.600.032
364TMEM204transmembrane protein 204Blood-1.580.013
365NLRC3NLR family, CARD domain containing 3Blood-1.580.035
366TYSND1trypsin domain containing 1Blood-1.560.035
367TARPTCR gamma alternate reading frame proteinBlood-1.560.025
368CDK10cyclin-dependent kinase 10Blood-1.550.038
369CD1CCD1c moleculeBlood-1.550.027
370TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)Blood-1.550.002
371TCTN1tectonic family member 1Blood-1.530.002
372NCALDneurocalcin deltaBlood-1.520.026
373RPS4Xribosomal protein S4, X-linkedBlood-1.510.001
374KLF12Kruppel-like factor 12Blood-1.510.043
375RPL5ribosomal protein L5Blood-1.470.012
376HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Blood-1.460.032
377CD7CD7 moleculeBlood-1.450.019
378EIF4Beukaryotic translation initiation factor 4BBlood-1.450.003
379BCAS4breast carcinoma amplified sequence 4Blood-1.440.017
380HLA-DPB1major histocompatibility complex, class II, DP beta 1Blood-1.440.031
381HOPXHOP homeoboxBlood-1.430.023
382MEF2Dmyocyte enhancer factor 2DBlood-1.430.001
383CD96CD96 moleculeBlood-1.430.019
384C12orf57chromosome 12 open reading frame 57Blood-1.430.017
385SKAP1src kinase associated phosphoprotein 1Blood-1.410.012
386HLA-DOAmajor histocompatibility complex, class II, DO alphaBlood-1.400.026
388NSUN5P2NOP2/Sun domain family, member 5 pseudogene 2Blood-1.380.036
389RPL4ribosomal protein L4Blood-1.380.016
390UBASH3Aubiquitin associated and SH3 domain containing ABlood-1.380.041
391EEF1Geukaryotic translation elongation factor 1 gammaBlood-1.370.028
392MXD4MAX dimerization protein 4Blood-1.370.004
393RPL15ribosomal protein L15Blood-1.370.040
394EIF3Leukaryotic translation initiation factor 3, subunit LBlood-1.370.006
395RPL3ribosomal protein L3Blood-1.360.030
396ADHFE1alcohol dehydrogenase, iron containing, 1Blood-1.340.042
397SEPT1septin 1Blood-1.330.050
398RPS6ribosomal protein S6Blood-1.330.039
399ATP6V0E2ATPase, H+ transporting V0 subunit e2Blood-1.320.038
400HLA-DMBmajor histocompatibility complex, class II, DM betaBlood-1.300.020

Expression patterns in normal tissues for genes affiliated with Influenza

Search GEO for disease gene expression data for Influenza.

Pathways for genes affiliated with Influenza

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Pathways related to Influenza according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
Show member pathways
10.0IFNB1, CXCL10, DDX58
Show member pathways
10.0IFNB1, CXCL10, DDX58
410.0IFNB1, CXCL10, PTPN11
Show member pathways
9.7PTPN11, IFNB1, IFITM3, MX2, MX1
Show member pathways
9.5DDX58, PTPN11, IFNB1, IFITM3, MX2, MX1
Show member pathways

Compounds for genes affiliated with Influenza

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Compounds related to Influenza according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1rebif4410.5MX1, IFNB1
2avonex4410.5MX1, IFNB1
3betaseron4410.5MX1, IFNB1
4monosaccharide4410.4NEU1, SFTPD
52,5-oligoadenylate4410.3CXCL10, IFNB1, MX1
6acyclovir44 1211.3NEU1, IFNB1
7polyinosinic-polycytidylic acid4410.3DDX58, CXCL10, IFNB1
8neopterin4410.3MX1, IFNB1, CXCL10
9dtpa4410.3XDH, IFNB1
10ribavirin44 50 1212.2NEU1, CXCL10, IFNB1, MX1
11tetracycline44 1211.2IFNB1, PTPN11, FURIN
12poly(i-c)4410.2MX1, IFNB1, CXCL10, DDX58
13ifn-alpha4410.2PTPN11, CXCL10, IFNB1, MX1
14adenine44 25 1212.2IFNB1, CXCL10, XDH
15sialic acid4410.2NEU1, IFNB1, PDPN
16Beta-D-Glucose25 1211.2IFNB1, SFTPD
17imiquimod44 60 29 1213.1MX1, IFNB1
18polysaccharide4410.1SFTPD, NEU1, IFNB1, PDPN
19endotoxin4410.0IFNB1, CXCL10, SFTPD
20rantes4410.0DDX58, PTPN11, CXCL10, IFNB1, MX1
21cycloheximide4410.0DDX58, NEU1, CXCL10, IFNB1, MX1
22thymidine44 2511.0IFNB1, CXCL10, PTPN11, SFTPD
23alanine449.9FURIN, PTPN11, CXCL10, IFNB1, MX1
24adenylate449.9IVNS1ABP, FURIN, CPSF4, CXCL10, IFNB1
25cysteine449.8XDH, FURIN, SFTPD, PTPN11, NEU1, IFNB1
26lipid449.7XDH, FURIN, SFTPD, PTPN11, CXCL10, IFNB1
27serine449.5FURIN, SFTPD, PTPN11, NEU1, IFNB1, MX1
28glucose449.3FURIN, SFTPD, PTPN11, CXCL10, IFNB1

GO Terms for genes affiliated with Influenza

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Biological processes related to Influenza according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to interferon-alphaGO:03545510.2MX2, IFITM3
2negative regulation of viral genome replicationGO:04507110.2MX1, IFITM3, IFNB1
3response to exogenous dsRNAGO:04333010.1IFNB1, DDX58
4regulation of type I interferon-mediated signaling pathwayGO:06033810.0IFNB1, PTPN11
5type I interferon signaling pathwayGO:0603379.9PTPN11, IFNB1, IFITM3, MX2, MX1
6defense response to virusGO:0516079.8MX1, MX2, IFITM3, IFNB1, CXCL10
7cytokine-mediated signaling pathwayGO:0192219.8PTPN11, IFNB1, IFITM3, MX2, MX1
8lung alveolus developmentGO:0482869.8PDPN, SFTPD
9response to virusGO:0096159.7MX1, MX2, IFITM3, IFNB1, IVNS1ABP, DDX58
10innate immune responseGO:0450879.7DDX58, SFTPD, PTPN11, IFNB1, MX1

Products for genes affiliated with Influenza

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Sources for Influenza

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27ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet