FLU
MCID: INF038
MIFTS: 69

Influenza (FLU) malady

Summaries for Influenza

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Flu is a respiratory infection caused by a number of viruses. the viruses pass through the air and enter your body through your nose or mouth. between 5% and 20% of people in the u.s. get the flu each year. the flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. symptoms of the flu come on suddenly and are worse than those of the common cold. they may include body or muscle aches chills cough fever headache sore throat is it a cold or the flu? colds rarely cause a fever or headaches. flu almost never causes an upset stomach. and "stomach flu" isn't really flu at all, but gastroenteritis. most people with the flu recover on their own without medical care. people with mild cases of the flu should stay home and avoid contact with others, except to get medical care. if you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. the main way to keep from getting the flu is to get a yearly flu vaccine. good hygiene, including hand washing, can also help. nih: national institute of allergy and infectious diseases

MalaCards: Influenza, also known as FLU, is related to pneumonia and hepatitis, and has symptoms including fever, chills and runny nose. An important gene associated with Influenza is MX1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)), and among its related pathways are Influenza A and Interferon Signaling. The drug influenza neuraminidase inhibitor [epc] and the compounds cysteine and lipid have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, t cells and lung, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A viral infectious disease that results in infection, located in respiratory tract, has material basis in influenzavirus a, has material basis in influenzavirus b, or has material basis in influenzavirus c, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. it is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

CDC:3 Flu activity is low in most of the United States, but a wave of influenza B virus activity is affecting parts of the country. It's possible that significant flu activity could continue into May. CDC still recommends that people get a flu vaccine if they have not yet this season. And remember that flu antiviral drugs are a second line of defense to treat flu illness. People at high risk of serious flu illness should call a health care provider if they get flu symptoms.

Wikipedia:63 Influenza, commonly known as \"the flu\", is an infectious disease of birds and mammals caused by RNA... more...

Aliases & Classifications for Influenza

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Aliases & Descriptions:

influenza 8 10 44 60
flu 8 33
influenza with non-respiratory manifestation 8
influenza with other manifestations nos 8
influenza with other manifestations 8


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Disease Ontology8 DOID:8469
ICD9CM27 487
MeSH34 D007251
NCIt39 C53482

Related Diseases for Influenza

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17GeneCards, 18GeneDecks
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Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 398)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.2SFTPD, NEU1, XDH, CXCL10
2hepatitis30.9IFNB1, XDH, CXCL10
3newcastle disease30.9IFNB1, NEU1, IVNS1ABP, CXCL10
4meningitis30.8CXCL10
5hepatitis b30.8MX1, CXCL10, IFNG
6vaccinia30.5FURIN
7respiratory failure30.5SFTPD
8arthritis30.5PTPN11, MX1, CXCL10, IVNS1ABP, IFNG
9mumps30.4NEU1
10measles30.4MX1, IFNB1
11encephalitis30.4MX1, CXCL10
12asthma30.3SFTPD, IFNG, IFNB1, NEU1, XDH, CXCL10
13severe acute respiratory syndrome30.3CXCL10
14aspergillosis30.3SFTPD, IFNG
15cystic fibrosis30.3FURIN, SFTPD
16rheumatoid arthritis30.2SFTPD, IFNG, IFNB1, IVNS1ABP, CXCL10, PTPN11
17systemic lupus erythematosus30.2PTPN11, MX1, CXCL10, IFNB1, IFNG
18hemophagocytic lymphohistiocytosis30.2IFNB1, MX1
19lupus erythematosus30.2MX1
20herpes simplex30.1MX1, CXCL10, NEU1, IFNB1
21chagas disease30.0NEU1
22hepatitis c29.9IFNG, IFNB1, CXCL10, MX1
23dermatomyositis29.9SFTPD, MX1
24allergic asthma29.9IFNB1, IFNG, SFTPD
25melanoma29.8IFNG, IFNB1, PDPN, NEU1, MAGEA3, XDH
26adenocarcinoma29.8SFTPD, IFNB1, PDPN, MAGEA3, CXCL10, FURIN
27malaria29.8XDH, NEU1, IFNG
28tuberculosis29.8SFTPD, IFNG, IFNB1, CXCL10
29diabetes mellitus29.8PTPN11, NEU1
30viral infectious disease29.8IFNG, IFNB1, NEU1, IVNS1ABP, XDH, CXCL10
31skin disease29.8SFTPD, IFNG, CXCL10, MX1
32alopecia areata29.8IFNG
33multiple sclerosis29.6IFNG, IFNB1, XDH, CXCL10, MX1
34sepsis29.6SFTPD, NEU1, XDH, FURIN
35kaposi's sarcoma29.6CXCL10, PDPN, IFNB1
36uveitis29.6CXCL10, IFNG
37sarcoidosis29.6SFTPD, IFNG, CXCL10
38japanese encephalitis29.6PTPN11, IVNS1ABP
39neutropenia29.6CXCL10, IFNB1
40lichen planus29.6MX1
41venezuelan equine encephalitis29.6FURIN
42bronchiolitis obliterans29.6CXCL10
43chronic inflammatory demyelinating polyradiculoneuropathy29.6IFNB1
44avian influenza11.1
45swine influenza11.1
46tetanus10.7
47pertussis10.6
48diphtheria10.6
49epiglottitis10.6
50hepatitis a10.5

Graphical network of the top 20 diseases related to Influenza:



Diseases related to influenza

Clinical Features for Influenza

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 8)
  • fever
  • chills
  • runny nose
  • muscle pains
  • sore throat
  • weakness
  • severe headache
  • cough

Drugs & Therapeutics for Influenza

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Influenza

Drug clinical trials:

Search ClinicalTrials for Influenza

Search NIH Clinical Center for Influenza

Search CenterWatch for Influenza

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Influenza

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Anatomical Context for Influenza

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Influenza:

32
T cells, Lung, Testes, Monocytes, Heart, Colon, B cells, Brain, Nk cells, Bone, Thyroid, Tonsil, Endothelial, Bone marrow, Kidney, Trachea, Spinal cord, Liver, Eye, Skin, Myeloid, Prostate

FMA organs/tissues related to Influenza:

14
Respiratory tract

Animal Models for Influenza or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Influenza:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.0PTPN11, SFTPD, IFNG, IFNB1, PDPN, NEU1
2MP:000538511.8PDPN, NEU1, IVNS1ABP, XYLB, CXCL10, PTPN11
3MP:000538711.7SFTPD, IFNG, IFNB1, PDPN, NEU1, XDH

Publications for Influenza

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Sources:
50PubMed
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Articles related to Influenza:

(show top 50)    (show all 3562)
idTitleAuthorsYear
1
Serendipitous discovery of a potent influenza virus a neuraminidase inhibitor. (24339250)
2014
2
Deep sequencing approach for genetic stability evaluation of influenza A viruses. (24406624)
2014
3
Rivers and flooded areas identified by medium-resolution remote sensing improve risk prediction of the highly pathogenic avian influenza H5N1 in Thailand. (24258895)
2013
4
Thrombocytopenia: An important presentation of new emerging H7N9 influenza. (23909680)
2013
5
Epidemiological survey of swine influenza A virus in the wild boar population of two Italian provinces. (24224815)
2013
6
Monitoring avian influenza A(H7N9) virus through national influenza-like illness surveillance, China. (23879887)
2013
7
Swine influenza viruses: an Asian perspective. (22266639)
2013
8
Optimal specimen collection and transport methods for the detection of avian influenza virus and Newcastle disease virus. (23432911)
2013
9
Relationships between rhinitis symptoms, respiratory viral infections and nasopharyngeal colonization with Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in children attending daycare. (23558321)
2013
10
The evaluation of a nucleoprotein ELISA for the detection of equine influenza antibodies and the differentiation of infected from vaccinated horses (DIVA). (24224822)
2013
11
Clinical and epidemiological survey and analysis of the first case of human infection with avian influenza A(H7N9) virus in Hangzhou, China. (23990172)
2013
12
Inhibitory influence of Enterococcus faecium on the propagation of swine influenza A virus in vitro. (23308134)
2013
13
Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REF. (24073193)
2013
14
Experimental infection of juvenile domestic and Canada geese with two different clades of H5N1 high pathogenicity avian influenza virus. (23465470)
2013
15
Myxovirus resistance gene A (MxA) expression suppresses influenza A virus replication in alpha interferon-treated primate cells. (23152507)
2013
16
Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia. (23790339)
2013
17
Predicting transmission of avian influenza A viruses from avian to human by using informative physicochemical properties. (23777174)
2013
18
The impact of geographical location of residence on disease outcomes among Canadian First Nations populations during the 2009 influenza A(H1N1) pandemic. (24370747)
2013
19
Imported pigs may have introduced the first classical swine influenza viruses into Mainland China. (23567818)
2013
20
Efficacy of influenza vaccination in patients with cirrhosis and inactive carriers of hepatitis B virus infection. (23285414)
2012
21
Rheumatoid arthritis and Swine influenza vaccine: a case report. (22953151)
2012
22
Acute disseminated encephalomyelitis following 2009 H1N1 influenza vaccine. (22830541)
2012
23
Can influenza H1N1 vaccination lead to the membranous glomerulonephritis? (22771654)
2012
24
Swine influenza virus infection in different age groups of pigs in farrow-to-finish farms in Thailand. (22166074)
2011
25
Phylogenetic analysis of swine influenza viruses isolated in Poland. (21077429)
2010
26
Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model. (19913271)
2010
27
Rapid selection of a transmissible multidrug-resistant influenza A/H3N2 virus in an immunocompromised host. (20350163)
2010
28
Hepatitis B response of premature infants after primary and booster immunisation with a diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus/haemophilus influenzae type B vaccine. (20396673)
2010
29
Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. (19124752)
2009
30
Two parameters characterizing 2009 H1N1 swine influenza epidemic in different countries/regions of the world. (19762998)
2009
31
Evidence for a novel gene associated with human influenza A viruses. (19917120)
2009
32
Clinical features of human influenza A (H5N1) infection in Vietnam: 2004-2006. (19435433)
2009
33
Identification of a human monoclonal Fab with neutralizing activity against H3N2 influenza A strain from a newly constructed human Fab library. (18402598)
2008
34
Rapid quantitation of neuraminidase inhibitor drug resistance in influenza virus quasispecies. (18839782)
2008
35
One-year post-primary antibody persistence and booster immune response to a fully liquid five-component acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenzae type b conjugate vaccine. (17349809)
2007
36
Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection. (17579046)
2007
37
Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001. (16809934)
2006
38
Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages. (16518756)
2006
39
Roles of neuraminidase in the initial stage of influenza virus infection. (16682242)
2006
40
Prevention of influenza in the general population. (15534315)
2004
41
The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. (14975239)
2004
42
Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: antimicrobial susceptibility patterns from the SENTRY antimicrobial Surveillance Program (United States and Canada, 1997). (9925540)
1999
43
Antigenic drift in swine influenza H3 haemagglutinins with implications for vaccination policy. (10195767)
1999
44
The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody. (7994573)
1994
45
Design and construction of rhinovirus chimeras incorporating immunogens from polio, influenza, and human immunodeficiency viruses. (7507283)
1994
46
Virucidal activity and viral protein modification by myeloperoxidase: a candidate for defense factor of human polymorphonuclear leukocytes against influenza virus infection. (1647427)
1991
47
Evolution to predominance of swine influenza virus hemagglutinin mutants of predictable phenotype during single infections of the natural host. (3186713)
1988
48
Nontypable Hemophilus influenzae infection of a congenital bronchogenic cyst. (3487619)
1986
49
Porcine fetuses with pulmonary hypoplasia resulting from experimental swine influenza virus infection. (6247813)
1980
50
Reye syndrome associated with Hemophilus influenzae infection. (6965903)
1980

Genetic Variations for Influenza

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Expression for genes affiliated with Influenza

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Influenza

Search GEO for disease gene expression data for Influenza.

Pathways for genes affiliated with Influenza

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Influenza

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Influenza according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1cysteine4412.0SFTPD, IFNG, IFNB1, NEU1, XDH, PTPN11
2lipid4411.9SFTPD, IFNB1, XDH, CXCL10, MX1, PTPN11
3ifn-alpha4411.7IFNG, IFNB1, CXCL10, MX1, PTPN11
4rantes4411.7PTPN11, MX1, CXCL10, IFNB1, IFNG
5thymidine44 2412.6PTPN11, CXCL10, IFNB1, IFNG, SFTPD
6adenylate4411.5IFNB1, IVNS1ABP, CXCL10, FURIN, CPSF4
72,5-oligoadenylate4411.5IFNG, IFNB1, CXCL10, MX1
8poly(i-c)4411.5MX1, CXCL10, IFNB1, IFNG
9neopterin4411.5IFNG, IFNB1, CXCL10, MX1
10ribavirin44 49 1113.4MX1, NEU1, IFNG
11betaseron4411.4MX1, IFNB1, IFNG
12acyclovir44 1112.3IFNG, IFNB1, NEU1
13imiquimod44 28 59 1114.3MX1, IFNB1, IFNG
14con a4411.3IFNG, NEU1, FURIN
15fluticasone propionate44 49 59 1114.3CXCL10, IFNB1, IFNG
16gsno4411.3IFNG, XDH, CXCL10
17polyinosinic-polycytidylic acid4411.3CXCL10, IFNB1, IFNG
18il 104411.3IFNG, IFNB1, CXCL10
19polysaccharide4411.3SFTPD, IFNB1, PDPN, NEU1
20tarc4411.3CXCL10, IFNB1, IFNG
21ccl344 2812.3IFNG, IFNB1, CXCL10
22allergens4411.2CXCL10, IFNG, SFTPD
23cycloheximide4411.2MX1, CXCL10, IFNB1
24rebif4411.2MX1, IFNB1
25carboplatin44 49 1113.2IFNG, IFNB1, XDH
26tetracycline44 1112.1FURIN, PTPN11, IFNB1
27avonex4411.1MX1, IFNB1
28histamine44 28 2413.1SFTPD, IFNG, NEU1, CXCL10
29sodium stibogluconate44 1112.1IFNG, PTPN11
30mezerein4410.9IFNB1, IFNG
31kynurenine4410.9IFNB1, IFNG
32monosaccharide4410.8NEU1, SFTPD
33d penicillamine4410.7XDH, IFNG
34glatiramer acetate44 1111.5IFNB1, IFNG

GO Terms for genes affiliated with Influenza

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16Gene Ontology
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Biological processes related to Influenza according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922111.7IFNG, IFITM3, IFNB1, MX1, MX2, PTPN11
2type I interferon-mediated signaling pathwayGO:06033711.5PTPN11, MX2, MX1, IFNB1, IFITM3
3response to virusGO:00961511.5IFNG, IFITM3, IFNB1, IVNS1ABP, MX1
4defense response to virusGO:05160711.5IFNG, IFITM3, IFNB1, CXCL10, MX1
5negative regulation of viral genome replicationGO:04507111.1MX1, IFNB1, IFITM3
6positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.9IFNG, IFNB1
7negative regulation of viral transcriptionGO:03289710.9IFITM3, IFNB1
8negative regulation of viral entry into host cellGO:04659710.8IFNB1, IFITM3
9adaptive immune responseGO:00225010.8IFNB1, IFNG
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IFNG, FURIN
11regulation of interferon-gamma-mediated signaling pathwayGO:06033410.5PTPN11, IFNG

Products for genes affiliated with Influenza

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Influenza

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet