MCID: INF039
MIFTS: 38

Infratentorial Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Infratentorial Cancer

MalaCards integrated aliases for Infratentorial Cancer:

Name: Infratentorial Cancer 12 14 69
Infratentorial Neoplasms 41 69
Malignant Infratentorial Tumors 12
Brain Neoplasm, Infratentorial 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4706
ICD10 32 C71.7
MeSH 41 D015192
NCIt 46 C3139 C4966

Summaries for Infratentorial Cancer

Disease Ontology : 12 A brain cancer that is located in the infratentorial region.

MalaCards based summary : Infratentorial Cancer, also known as infratentorial neoplasms, is related to medulloblastoma and childhood infratentorial neoplasm. An important gene associated with Infratentorial Cancer is SHH (Sonic Hedgehog), and among its related pathways/superpathways are G-Beta Gamma Signaling and Pathways in cancer. Affiliated tissues include the infratentorial region and brain, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Infratentorial Cancer

Diseases related to Infratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 medulloblastoma 29.3 CTNNB1 GLI1 KCTD11 MYC MYCN NES
2 childhood infratentorial neoplasm 12.1
3 vulva basal cell carcinoma 10.4 MYC PTCH1
4 holoprosencephaly, recurrent infections, and monocytosis 10.4 GLI2 PTCH1
5 septopreoptic holoprosencephaly 10.4 GLI2 PTCH1 SHH
6 midline interhemispheric variant of holoprosencephaly 10.4 GLI2 PTCH1 SHH
7 alobar holoprosencephaly 10.4 GLI2 PTCH1 SHH
8 lobar holoprosencephaly 10.4 GLI2 PTCH1 SHH
9 calcifying epithelial odontogenic tumor 10.4 GLI2 PTCH1 TP53
10 holoprosencephaly 4 10.4 GLI3 MYC SHH
11 semilobar holoprosencephaly 10.4 GLI2 PTCH1 SHH
12 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.4 GLI1 GLI2 SHH
13 embryonal rhabdomyosarcoma 10.4 GLI1 MYCN PTCH1
14 combined pituitary hormone deficiencies, genetic forms 10.3 GLI2 OTX2
15 desmoplastic infantile ganglioglioma 10.3 MYCN SYP
16 gastric squamous cell carcinoma 10.3 GLI1 SHH SYP
17 cerebral ventricle cancer 10.3 IER3IP1 SYP TP53
18 tracheoesophageal fistula 10.3 GLI3 MYCN SHH
19 cerebrum cancer 10.3 IER3IP1 SYP TP53
20 gastric tubular adenocarcinoma 10.3 GLI1 SHH SYP
21 supratentorial cancer 10.3 IER3IP1 SYP TP53
22 agnathia-otocephaly complex 10.3 GLI2 OTX2 SHH
23 microform holoprosencephaly 10.3 GLI2 PTCH1 SHH SUFU
24 adult hepatocellular carcinoma 10.3 CTNNB1 TP53
25 rhabdomyosarcoma 10.2 GLI1 MYCN PTCH1 TP53
26 physical disorder 10.2 GLI3 IER3IP1 SHH
27 keratocystic odontogenic tumor 10.2 GLI1 PTCH1 SHH SUFU TP53
28 pallister-hall syndrome 10.2 GLI1 GLI2 GLI3 SHH
29 central nervous system organ benign neoplasm 10.2 CTNNB1 SYP TP53
30 esophageal atresia 10.2 GLI2 GLI3 MYCN SHH
31 central nervous system primitive neuroectodermal neoplasm 10.2 NES SYP TP53
32 cellular ependymoma 10.2 SYP TP53
33 female reproductive organ cancer 10.2 CTNNB1 MYC TP53
34 cerebral primitive neuroectodermal tumor 10.2 MYC MYCN SYP TP53
35 holoprosencephaly 10.1 GLI2 GLI3 PTCH1 SHH
36 peripheral nervous system neoplasm 10.1 MYC MYCN SYP TP53
37 autonomic nervous system neoplasm 10.1 MYC MYCN SYP TP53
38 optic nerve neoplasm 10.1 NES SYP TP53
39 organ system benign neoplasm 10.1 CTNNB1 SYP TP53
40 meningioma, familial 10.1 PTCH1 SUFU SYP TP53
41 optic nerve glioma 10.1 NES SYP TP53
42 endocrine gland cancer 10.1 PTCH1 SYP TP53
43 ganglioglioma 10.1 NES SYP TP53
44 small cell cancer of the lung 10.1 MYC MYCN SYP TP53
45 cell type benign neoplasm 10.1 CTNNB1 SYP TP53
46 bardet-biedl syndrome 17 10.1 GLI2 PROM1 PTCH1 SHH
47 reproductive organ cancer 10.1 CTNNB1 MYC TP53
48 cerebellum cancer 10.0 ATOH1 PTCH1 SUFU SYP TP53
49 cerebellar liponeurocytoma 10.0 ATOH1 PTCH1 SUFU SYP TP53
50 nodular medulloblastoma 10.0 CTNNB1 GLI1 GLI2 PTCH1 SUFU

Graphical network of the top 20 diseases related to Infratentorial Cancer:



Diseases related to Infratentorial Cancer

Symptoms & Phenotypes for Infratentorial Cancer

MGI Mouse Phenotypes related to Infratentorial Cancer:

43 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 CTNNB1 ATOH1 GLI1 GLI2 MYC PROM1
2 growth/size/body region MP:0005378 10.41 CTNNB1 GLI1 GLI3 GLI2 MYC PROM1
3 digestive/alimentary MP:0005381 10.4 GLI2 ATOH1 GLI1 CTNNB1 MYC GLI3
4 mortality/aging MP:0010768 10.4 CTNNB1 ATOH1 GLI1 GLI3 GLI2 MYC
5 cardiovascular system MP:0005385 10.39 CTNNB1 GLI3 MYC PROM1 SHH PTCH1
6 cellular MP:0005384 10.38 GLI1 CTNNB1 ATOH1 MYC GLI3 GLI2
7 nervous system MP:0003631 10.35 ATOH1 GLI1 CTNNB1 GLI3 GLI2 MYC
8 craniofacial MP:0005382 10.34 GLI1 CTNNB1 GLI3 GLI2 MYC SHH
9 embryo MP:0005380 10.32 CTNNB1 GLI1 GLI3 GLI2 MYC SHH
10 normal MP:0002873 10.31 GLI2 ATOH1 GLI1 CTNNB1 MYCN MYC
11 endocrine/exocrine gland MP:0005379 10.27 GLI1 CTNNB1 ATOH1 MYC GLI3 GLI2
12 no phenotypic analysis MP:0003012 10.27 GLI2 ATOH1 GLI1 CTNNB1 MYC GLI3
13 hearing/vestibular/ear MP:0005377 10.26 GLI2 ATOH1 CTNNB1 MYC GLI3 SHH
14 limbs/digits/tail MP:0005371 10.24 GLI1 CTNNB1 GLI3 GLI2 MYC SHH
15 integument MP:0010771 10.2 CTNNB1 ATOH1 MYC GLI3 GLI2 SHH
16 muscle MP:0005369 10.16 CTNNB1 MYC GLI2 PTCH1 SHH PPP1R12A
17 neoplasm MP:0002006 10.1 CTNNB1 GLI1 MYC PTCH1 PROM1 SHH
18 respiratory system MP:0005388 10.03 GLI2 ATOH1 GLI1 CTNNB1 GLI3 SHH
19 reproductive system MP:0005389 10.02 GLI1 CTNNB1 MYC GLI3 GLI2 PTCH1
20 pigmentation MP:0001186 10.01 CTNNB1 GLI3 MYC PTCH1 PROM1 OTX2
21 renal/urinary system MP:0005367 9.97 GLI1 CTNNB1 GLI3 SHH PTCH1 PPP1R12A
22 skeleton MP:0005390 9.85 CTNNB1 MYC GLI3 GLI2 PTCH1 SHH
23 vision/eye MP:0005391 9.36 CTNNB1 GLI3 GLI2 PROM1 SHH PTCH1
24 taste/olfaction MP:0005394 9.35 CTNNB1 GLI3 SHH PTCH1 OTX2

Drugs & Therapeutics for Infratentorial Cancer

Search Clinical Trials , NIH Clinical Center for Infratentorial Cancer

Cochrane evidence based reviews: infratentorial neoplasms

Genetic Tests for Infratentorial Cancer

Anatomical Context for Infratentorial Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Infratentorial Cancer:

18
The Infratentorial Region

MalaCards organs/tissues related to Infratentorial Cancer:

38
Brain

Publications for Infratentorial Cancer

Variations for Infratentorial Cancer

Expression for Infratentorial Cancer

Search GEO for disease gene expression data for Infratentorial Cancer.

Pathways for Infratentorial Cancer

Pathways related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 CTNNB1 GLI1 GLI2 GLI3 PTCH1 SUFU
2 12.53 CTNNB1 GLI1 GLI2 GLI3 MYC PTCH1
3
Show member pathways
12.47 GLI1 GLI2 GLI3 PTCH1 SHH SUFU
4
Show member pathways
12.19 GLI1 GLI3 PPP1R12A PTCH1
5 12.15 CTNNB1 MYC PPP1R12A PTCH1 SHH TP53
6 12.14 MYC MYCN PROM1 TP53
7 12.01 CTNNB1 GLI3 MYC SHH
8 11.95 MYC NES OTX2 PROM1 SHH
9 11.88 CTNNB1 MED27 MYC TP53
10
Show member pathways
11.84 GLI1 GLI2 GLI3 PTCH1 SHH SUFU
11 11.76 CTNNB1 GLI1 GLI2 PROM1 PTCH1 SHH
12 11.68 NES PROM1 SHH SYP
13 11.59 MYC MYCN TP53
14
Show member pathways
11.59 CTNNB1 GLI1 GLI2 GLI3 PTCH1 SHH
15 11.58 MYC NTRK3 TP53
16 11.3 GLI1 GLI2 PTCH1 SHH
17 11.23 CTNNB1 MYC TP53
18
Show member pathways
11.22 GLI2 PTCH1 SHH
19 11.1 GLI1 GLI2 OTX2 SHH
20
Show member pathways
11.01 MYC OTX2 TP53
21 10.57 GLI3 SHH
22 10.48 PTCH1 SHH
23 10.26 MYC MYCN

GO Terms for Infratentorial Cancer

Cellular components related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.63 GLI1 GLI2 GLI3 PROM1 PTCH1 SUFU
2 axoneme GO:0005930 9.43 GLI1 GLI2 GLI3
3 ciliary tip GO:0097542 9.26 GLI1 GLI2 GLI3 SUFU
4 ciliary base GO:0097546 8.92 GLI1 GLI2 GLI3 SUFU

Biological processes related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.99 CTNNB1 GLI2 GLI3 SHH
2 canonical Wnt signaling pathway GO:0060070 9.98 CTNNB1 GLI1 MYC SHH
3 forebrain development GO:0030900 9.96 CTNNB1 GLI3 OTX2 SHH
4 positive regulation of transcription, DNA-templated GO:0045893 9.96 CTNNB1 GLI1 GLI2 GLI3 MYC MYCN
5 anterior/posterior pattern specification GO:0009952 9.94 GLI2 GLI3 SHH
6 odontogenesis of dentin-containing tooth GO:0042475 9.94 CTNNB1 GLI2 GLI3 SHH
7 positive regulation of neuron differentiation GO:0045666 9.93 ATOH1 GLI2 KCTD11
8 negative regulation of cell death GO:0060548 9.93 CTNNB1 MYC NTRK3
9 pattern specification process GO:0007389 9.93 GLI2 GLI3 PTCH1 SHH
10 cellular response to drug GO:0035690 9.92 MYC PPP1R12A TP53
11 negative regulation of cell differentiation GO:0045596 9.92 CTNNB1 GLI3 SHH
12 smoothened signaling pathway GO:0007224 9.92 GLI1 GLI2 GLI3 PTCH1 SHH
13 inner ear development GO:0048839 9.91 ATOH1 GLI3 SHH
14 embryonic limb morphogenesis GO:0030326 9.91 GLI3 PTCH1 SHH
15 liver regeneration GO:0097421 9.91 GLI1 GLI3 MYC PTCH1
16 skin development GO:0043588 9.9 CTNNB1 SHH SUFU
17 limb development GO:0060173 9.9 CTNNB1 GLI3 SHH
18 midbrain development GO:0030901 9.9 CTNNB1 OTX2 SHH
19 branching morphogenesis of an epithelial tube GO:0048754 9.9 GLI2 GLI3 MYCN SHH
20 embryonic organ development GO:0048568 9.89 GLI3 PTCH1 SHH
21 mammary gland development GO:0030879 9.89 GLI2 GLI3 PTCH1
22 positive regulation of mesenchymal cell proliferation GO:0002053 9.89 CTNNB1 MYC MYCN SHH
23 developmental growth GO:0048589 9.87 GLI2 GLI3 SHH
24 T cell differentiation in thymus GO:0033077 9.87 CTNNB1 GLI3 SHH
25 renal system development GO:0072001 9.86 CTNNB1 PTCH1 SHH
26 proximal/distal pattern formation GO:0009954 9.86 CTNNB1 GLI1 GLI2 GLI3
27 hindbrain development GO:0030902 9.85 CTNNB1 GLI2 SHH
28 positive regulation of neuroblast proliferation GO:0002052 9.85 CTNNB1 GLI3 SHH
29 regulation of smoothened signaling pathway GO:0008589 9.85 GLI1 GLI2 OTX2 PTCH1
30 negative regulation of smoothened signaling pathway GO:0045879 9.84 GLI3 KCTD11 PTCH1 SUFU
31 anatomical structure formation involved in morphogenesis GO:0048646 9.83 GLI2 GLI3 SHH
32 anatomical structure development GO:0048856 9.83 GLI2 GLI3 SHH
33 embryonic digit morphogenesis GO:0042733 9.83 CTNNB1 GLI2 GLI3 MYCN SHH
34 dorsal/ventral neural tube patterning GO:0021904 9.82 GLI2 PTCH1 SHH
35 branching involved in ureteric bud morphogenesis GO:0001658 9.8 CTNNB1 GLI3 MYC PTCH1 SHH
36 lung development GO:0030324 9.8 CTNNB1 GLI1 GLI2 GLI3 MYCN SHH
37 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.79 GLI2 GLI3 PTCH1
38 regulation of osteoblast differentiation GO:0045667 9.76 CTNNB1 GLI1
39 ectoderm development GO:0007398 9.76 CTNNB1 SHH
40 layer formation in cerebral cortex GO:0021819 9.76 CTNNB1 GLI3
41 negative regulation of astrocyte differentiation GO:0048712 9.76 MYCN NTRK3
42 spinal cord motor neuron differentiation GO:0021522 9.76 GLI2 GLI3 PTCH1 SHH
43 positive regulation of alpha-beta T cell differentiation GO:0046638 9.75 GLI3 SHH
44 negative thymic T cell selection GO:0045060 9.75 GLI3 SHH
45 embryonic foregut morphogenesis GO:0048617 9.75 CTNNB1 SHH
46 positive regulation of T cell differentiation in thymus GO:0033089 9.75 GLI2 SHH
47 positive regulation of skeletal muscle tissue development GO:0048643 9.75 CTNNB1 SHH
48 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.75 GLI1 GLI2 SHH
49 artery development GO:0060840 9.74 GLI3 SHH
50 negative regulation of cell division GO:0051782 9.74 MYC PTCH1

Molecular functions related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.8 ATOH1 GLI2 GLI3 MYC OTX2 TP53
2 chromatin binding GO:0003682 9.77 CTNNB1 GLI1 GLI2 GLI3 TP53
3 transcription regulatory region DNA binding GO:0044212 9.76 CTNNB1 GLI1 GLI2 TP53
4 DNA binding transcription factor activity GO:0003700 9.76 ATOH1 CTNNB1 GLI2 GLI3 MYC MYCN
5 transcription factor binding GO:0008134 9.65 CTNNB1 GLI2 MYC SUFU TP53
6 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.43 ATOH1 GLI2 GLI3 MYC MYCN OTX2
7 patched binding GO:0005113 9.4 PTCH1 SHH
8 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.23 ATOH1 CTNNB1 GLI1 GLI2 GLI3 MYC
9 DNA binding GO:0003677 10.09 ATOH1 CTNNB1 GLI1 GLI2 GLI3 MYC

Sources for Infratentorial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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