MCID: ING001
MIFTS: 57

Inguinal Hernia

Categories: Gastrointestinal diseases

Aliases & Classifications for Inguinal Hernia

Summaries for Inguinal Hernia

Disease Ontology : 12 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

MalaCards based summary : Inguinal Hernia, also known as hernia, inguinal, is related to arthrogryposis multiplex with deafness, inguinal hernias, and early death and marfanoid habitus-inguinal hernia-advanced bone age syndrome. An important gene associated with Inguinal Hernia is FBN1 (Fibrillin 1), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. The drugs Bupivacaine and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and testis, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 An inguinal hernia is a protrusion of abdominal-cavity contents through the inguinal canal. Symptoms are... more...

Related Diseases for Inguinal Hernia

Diseases related to Inguinal Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
id Related Disease Score Top Affiliating Genes
1 arthrogryposis multiplex with deafness, inguinal hernias, and early death 12.0
2 marfanoid habitus-inguinal hernia-advanced bone age syndrome 12.0
3 lambert syndrome 11.7
4 persistent mullerian duct syndrome 11.3
5 pseudomyxoma peritonei 11.2
6 short syndrome 11.0
7 spondylocostal dysostosis 3, autosomal recessive 11.0
8 cutis laxa, autosomal recessive, type ia 11.0
9 bosma arhinia microphthalmia syndrome 10.9
10 spinal muscular atrophy, x-linked 2, infantile 10.9
11 aarskog-scott syndrome 10.9
12 2q37 deletion syndrome 10.9
13 mucopolysaccharidosis ii 10.9
14 hyperekplexia, hereditary 1, autosomal dominant or recessive 10.9
15 acrofacial dysostosis, catania type 10.9
16 deafness, epiphyseal dysplasia, short stature 10.9
17 achondrogenesis ib 10.9
18 focal segmental glomerulosclerosis 10.9
19 ichthyosis follicularis atrichia photophobia syndrome 10.9
20 testicular anomalies with or without congenital heart disease 10.9
21 facial arteriovenous malformation 10.7 MMP2 MMP9
22 familial short qt syndrome 10.7 MMP2 MMP9
23 metaphyseal undermodeling, spondylar dysplasia, and overgrowth 10.7 MMP13 MMP9
24 liver lymphoma 10.7 MMP1 MMP2
25 leucocyte adhesion defect 10.7 MMP2 MMP9
26 transitional meningioma 10.6 MMP2 MMP9
27 childhood endodermal sinus tumor 10.6 MMP9 TIMP2
28 collagenous colitis 10.6 MMP2 MMP9
29 sialadenitis 10.6 MMP2 MMP9
30 early myoclonic encephalopathy 10.6 MMP1 MMP9
31 skin amelanotic melanoma 10.6 MMP1 MMP2 TIMP2
32 kleptomania 10.6 MMP1 MMP2 MMP9
33 xanthogranulomatous cholecystitis 10.5 MMP1 MMP2 MMP9
34 limbic encephalitis 10.5 MMP1 MMP2 MMP9
35 oligomeganephronic renal hypoplasia 10.5 MMP1 MMP2 MMP9
36 laryngostenosis 10.5 MMP1 MMP2 MMP9
37 corneal staphyloma 10.5 MMP2 MMP9
38 rheumatic myocarditis 10.5 IL6 MMP1 MMP13
39 elastoma 10.5 ELN FBN1
40 tinea profunda 10.5 ELN MMP2 MMP9
41 early-onset generalized limb-onset dystonia 10.5 ELN FBN1
42 ectropion 10.5 MMP1 MMP9
43 congenital heart defects and skeletal malformations syndrome 10.5 ELN MMP1 MMP2
44 familial or sporadic hemiplegic migraine 10.5 ELN FBN1
45 osteogenesis imperfecta, type x 10.5 IL6 MMP1 TIMP2
46 nail disorder, nonsyndromic congenital, 1 10.4 MMP1 MMP2 TIMP2
47 drug rash with eosinophilia and systemic symptoms 10.4 IL6 MMP2 MMP9
48 bardet-biedl syndrome 8 10.4 ELN IL6 MMP1
49 synovium cancer 10.4 IL6 MMP1 MMP13
50 tricho onychic dysplasia 10.4 IL6 MMP2 MMP9

Graphical network of the top 20 diseases related to Inguinal Hernia:



Diseases related to Inguinal Hernia

Symptoms & Phenotypes for Inguinal Hernia

MGI Mouse Phenotypes related to Inguinal Hernia:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 MMP9 TBX1 TBX2 TIMP1 TIMP2 ADAMTS6
2 homeostasis/metabolism MP:0005376 10.28 ADAMTS6 AR FBN1 GATA6 IL6 ITGA3
3 growth/size/body region MP:0005378 10.26 ADAMTS6 AR FBN1 GATA6 IL6 ITGA3
4 hematopoietic system MP:0005397 10.16 TIMP2 ADAMTS6 AR FBN1 GATA6 IL6
5 immune system MP:0005387 10.14 MMP9 TBX1 TIMP1 TIMP2 ADAMTS6 AR
6 digestive/alimentary MP:0005381 10.04 ADAMTS6 AR IL6 ITGA3 MMP9 TBX1
7 limbs/digits/tail MP:0005371 10.02 ADAMTS6 AR FBN1 GATA6 ITGA3 MMP13
8 craniofacial MP:0005382 9.99 ADAMTS6 AR FBN1 MMP2 TBX1 TBX2
9 integument MP:0010771 9.91 AR FBN1 IL6 ITGA3 MMP13 MMP9
10 muscle MP:0005369 9.8 AR FBN1 GATA6 IL6 MMP2 MMP9
11 neoplasm MP:0002006 9.7 AR IL6 ITGA3 MMP1 MMP2 MMP9
12 respiratory system MP:0005388 9.56 MMP9 TBX1 TIMP1 FBN1 GATA6 IL6
13 skeleton MP:0005390 9.28 ADAMTS6 AR FBN1 IL6 MMP13 MMP2

Drugs & Therapeutics for Inguinal Hernia

Drugs for Inguinal Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 172)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
2
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3 76-42-6 5284603
3
Ropivacaine Approved Phase 4,Phase 2 84057-95-4 71273 175805
4
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2 59467-70-8 4192
5
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
6
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
7
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
8
Levobupivacaine Approved Phase 4,Phase 2 27262-47-1 92253
9
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
10
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
11
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
13
Chloroprocaine Approved Phase 4 133-16-4 8612
14
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
15
Clonidine Approved Phase 4,Phase 3,Phase 2 4205-90-7 2803
16
Tizanidine Approved Phase 4 51322-75-9 5487
17
Prilocaine Approved Phase 4 721-50-6 4906
18
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
19
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
20
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
21
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
22
Rocuronium Approved Phase 4,Phase 3 119302-91-9, 143558-00-3 441290
23
Remifentanil Approved Phase 4 132875-61-7 60815
24
Ondansetron Approved Phase 4 99614-02-5 4595
25
Gabapentin Approved, Investigational Phase 4,Phase 2,Phase 3 60142-96-3 3446
26
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
27
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
28
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
29
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
30
Ketobemidone Approved Phase 4 469-79-4 10101
31
Meperidine Approved Phase 4 57-42-1 4058
32
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
33 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
34
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
35
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
36 Central Nervous System Stimulants Phase 4
37 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
38 Phosphodiesterase Inhibitors Phase 4
39 Purinergic P1 Receptor Antagonists Phase 4
40 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1
42 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Analgesics Phase 4,Phase 3,Phase 2,Early Phase 1
45 Analgesics, Opioid Phase 4,Phase 3
46 Narcotics Phase 4,Phase 3,Phase 2
47 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
48 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
49 Coagulants Phase 4,Phase 3
50 Fibrin Tissue Adhesive Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 294)

id Name Status NCT ID Phase Drugs
1 Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair Unknown status NCT00960011 Phase 4
2 Study of Surgical Mesh for Inguinal Hernia Repair Unknown status NCT00924755 Phase 4
3 Ultrasound-guided Ilioinguinal-iliohypogastric Block for Inguinal Hernia Repair Unknown status NCT01326039 Phase 4 bupivacaine;saline
4 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
5 Rebound Hernia Repair Device Mesh Trial Unknown status NCT00968773 Phase 4
6 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
7 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
8 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
9 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair Completed NCT01117337 Phase 4
10 Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias Completed NCT01264003 Phase 4 sefazolin
11 Strattice in Repair of Inguinal Hernias Completed NCT00681291 Phase 4
12 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
13 Efficacy Study of Tissucol/Tisseel Fibrin Sealant to Treat Inguinal Hernia Completed NCT00306839 Phase 4
14 Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery Completed NCT01521481 Phase 4
15 PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results Completed NCT00580177 Phase 4
16 Intrathecal Morphine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4 intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg;intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg;intravenous cannulation and premedication
17 Prospective Randomized Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis Completed NCT00614419 Phase 4
18 Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair Completed NCT01273818 Phase 4 Gentamicin and cefazolin;Cefazolin;Gentamicin
19 Evaluation of Dexamethasone Added to the Usual Infiltration With Bupivacaine in Inguinal Hernia Repair Mesh Completed NCT03007927 Phase 4 Bupivacaine-Dexamethasone;Bupivacaine- physiological solution
20 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4 Chloroprocaine;Marcaine
21 Parietex Progrip Study Completed NCT00827944 Phase 4
22 Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair Completed NCT01141335 Phase 4
23 Tizanidine and Pain After Herniorrhaphy Completed NCT02016443 Phase 4 Tizanidine;Placebo
24 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
25 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine Completed NCT01921231 Phase 4 Hyperbaric Prilocaine 1%;Hyperbaric bupivacaine 0.5%
26 Comparison of Oral Zaldiar With Intravenous Paracetamol and Tramadol Completed NCT02389361 Phase 4 Zaldiar;Paracetamol-Tramadol
27 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
28 Ultrasound-guided Rectus Sheath Block In Children Completed NCT02291705 Phase 4 Tramadol
29 Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty Completed NCT01943760 Phase 4 tramadol;0.9% saline
30 Recovery of Bupivacaine or Bupivacaine-Lidocaine Spinal Anesthesia and Infiltration Anesthesia in Herniorrhaphy Completed NCT01548794 Phase 4
31 The Effect of Induction Technique on Postoperative Pain and Agitation Completed NCT02110745 Phase 4 Sevofluorane;Propofol
32 Comparison Of The Analgesia Obtained By Infiltration For The Joinings Of Episiotomies (Liropep) Completed NCT00727935 Phase 4 Lidocaïne;Ropivacaïne;Placebo
33 Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial Completed NCT02152592 Phase 4 PCM/Oxy1;PCM/Oxy2
34 The Efficacy of Transversus Abdominis Plane Block After Groin Hernia Repair Completed NCT01052285 Phase 4
35 AbsorbaTack Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair Completed NCT00749268 Phase 4
36 Effects of Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair Recruiting NCT02055053 Phase 4 0.5% Bupivicaine
37 Postoperative Effects of TAP Block Versus QLB Type 2 Block Recruiting NCT03126084 Phase 4 Acetaminophen;0.25% Bupivacaine;0.5% Bupivacaine+Glucose;Tramadol HCl;0.25% Bupivacaine
38 Exparel Injection for Postoperative Orbital Pain Recruiting NCT02381353 Phase 4 Bupivacaine
39 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Active, not recruiting NCT02419443 Phase 4 Gabapentin;Placebo
40 A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants Active, not recruiting NCT00756600 Phase 4 Regional Anesthesia;General Anesthesia
41 The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During Spinal Anesthesia Active, not recruiting NCT03121261 Phase 4 levobupivacaine;clonidine
42 Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair Enrolling by invitation NCT02958878 Phase 4 Tamsulosin;Placebo Oral Capsule
43 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Enrolling by invitation NCT02527083 Phase 4 Propofol;Sevoflurane;Remifentanil;Ketamine
44 Effectiveness of a Quadratus Lumborum 3 Block vs. a TAP-block for Inguinal Hernia Repair Not yet recruiting NCT03023462 Phase 4 Oksykodonhydroklorid;Ketobemidone Hydrochloride;Ondansetron and Droperidol;Ropivacaine
45 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Not yet recruiting NCT02292095 Phase 4
46 The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children Not yet recruiting NCT02646709 Phase 4 Rocuronium;ketamine 1;ketamine 1.5;ketamine 2
47 Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair Unknown status NCT01069055 Phase 3 Intravenous lornoxicam;Intravenous paracetamol
48 Laparoscopic Inguinal Hernia Repair in Infancy and Childhood Unknown status NCT02239185 Phase 3
49 Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain Unknown status NCT01450345 Phase 3 Pregabalin
50 A Trial of Local Anaesthesia Versus Local Anaesthesia and Conscious Sedation for Hernioplasty Unknown status NCT02444260 Phase 3 Midazolam;Intravenous Normal Saline;Bupivocaine;Lignocaine HCl

Search NIH Clinical Center for Inguinal Hernia

Cochrane evidence based reviews: hernia, inguinal

Genetic Tests for Inguinal Hernia

Genetic tests related to Inguinal Hernia:

id Genetic test Affiliating Genes
1 Inguinal Hernia 29

Anatomical Context for Inguinal Hernia

MalaCards organs/tissues related to Inguinal Hernia:

39
Colon, Testes, Testis, Endothelial, Prostate, Uterus, Ovary

Publications for Inguinal Hernia

Articles related to Inguinal Hernia:

(show top 50) (show all 364)
id Title Authors Year
1
Is there a Place for Prebiotics in the Management of Neonatal Inguinal Hernia? A Preliminary Study. ( 28083493 )
2017
2
Absorbable Meshes in Inguinal Hernia Surgery: A Systematic Review and Meta-Analysis. ( 28492358 )
2017
3
Exploration Of The Contralateral Groin In Paediatric Inguinal Hernia Or Hydrocele Based On Ultrasound Findings - Is It Justified? ( 28712167 )
2017
4
Desarda's technique versus Lichtenstein technique for the treatment of primary inguinal hernia: a systematic review and meta-analysis of randomized controlled trials. ( 28889330 )
2017
5
An omental fibroma resembling a testicular tumour but presented as an irreducible inguinal hernia. ( 28852466 )
2017
6
A systematic review and meta-analysis concerning single-site laparoscopic percutaneous extraperitoneal closure for pediatric inguinal hernia and hydrocele. ( 28389795 )
2017
7
Comparison of Spinal Anesthesia and Paravertebral Block in Inguinal Hernia Repair. ( 28928578 )
2017
8
Mesh Displacement After Bilateral Inguinal Hernia Repair With No Fixation. ( 28904521 )
2017
9
A comparison of preoperative and postoperative testicular volume and blood flow in patients with inguinal hernia, hydrocele, and cord cyst: A prospective cohort study. ( 28523038 )
2017
10
Mesh Erosion into Sigmoid Colon after Inguinal Hernia Repair. ( 28469114 )
2017
11
An inguinal hernia with cryptorchidism with a Leydig cell tumor in an elderly man: A case report. ( 28171846 )
2017
12
Explaining variation in ventral and inguinal hernia repair outcomes: A population-based analysis. ( 28528663 )
2017
13
The Case of Huge Pure Lipoma of the Spermatic Cord Misdiagnosed as Inguinal Hernia. ( 28417076 )
2017
14
Approach to inguinal hernia in high-risk geriatric patients: Should it be elective or emergent? ( 28467578 )
2017
15
Persistent postherniorrhaphy pain following inguinal hernia repair: A cross-sectional study of prevalence, pain characteristics, and effects on quality of life. ( 28890413 )
2017
16
A Comparison of Three Different Volumes of Levobupivacaine for Caudal Block in Children Undergoing Orchidopexy and Inguinal Hernia Repair. ( 28437787 )
2017
17
Lichtenstein Versus Total Extraperitoneal Patch Plasty Versus Transabdominal Patch Plasty Technique for Primary Unilateral Inguinal Hernia Repair: A Registry-based, Propensity Score-matched Comparison of 57,906 Patients. ( 28953552 )
2017
18
Laparoscopic extraperitoneal repair versus open inguinal hernia repair: 20-year follow-up of a randomized controlled trial. ( 28864955 )
2017
19
Migration of a ventriculoperitoneal shunt catheter through the processus vaginalis in infants: how serious inguinal hernia and hydrocele might be. ( 28616670 )
2017
20
One trocar needlescopic assisted inguinal hernia repair in children: a novel technique. ( 28947323 )
2017
21
Transabdominal Preperitoneal (TAPP) versus Lichtenstein operation for primary inguinal hernia repair - A systematic review and meta-analysis of randomized controlled trials. ( 28490321 )
2017
22
A Prospective Comparative Observational Study of Clinical Efficacy of Isobaric Ropivacaine 0.75% with of Isobaric Bupivacaine 0.5% Intrathecally in Elective Inguinal Hernia Repair Surgeries. ( 28928548 )
2017
23
Protective multimodal analgesia with etoricoxib and spinal anesthesia in inguinal hernia repair: a randomized controlled trial. ( 28455600 )
2017
24
Persistent Mullerian Duct Syndrome Presenting in an Incarcerated Recurrent Inguinal Hernia with Hydrocele. ( 28331809 )
2017
25
Long-term results of the plugging method with regard to the prevention of a postoperative inguinal hernia after robot-assisted laparoscopic prostatectomy: a retrospective study. ( 28931316 )
2017
26
Single-incision totally extraperitoneal inguinal hernia repair is feasible and safe in patients on antithrombotic therapy: A single-center experience of 92 procedures. ( 28516514 )
2017
27
Eosinophilic funiculitis initially diagnosed as irreducible inguinal hernia: A case report. ( 28437672 )
2017
28
A Prospective Nonrandomized Study of Comparison of Perioperative and Quality of Life Outcomes of Endoscopic Versus Open Inguinal Hernia Repair: Data from a Developing Country. ( 28051905 )
2017
29
Extra-gastrointestinal anisakidosis caused by Pseudoterranova azarasi manifesting as strangulated inguinal hernia. ( 28927907 )
2017
30
Bilateral inguinal hernia after axillary-femoral artery bypass effectively treated with laparoscopic repair: A case report. ( 28436213 )
2017
31
Laparoscopic recurrent inguinal hernia repair during the learning curve: it can be done? ( 28447970 )
2017
32
Caution! The potential overestimated effect of prophylactic alpha-blockade for the prevention of urinary retention following primary inguinal hernia repair in a meta-analysis of randomized controlled trials. ( 28468725 )
2017
33
Inguinal hernia containing urinary bladder-A case report. ( 28923679 )
2017
34
Reduction of Inguinal Hernia Ureteral Entrapment. ( 28532750 )
2017
35
Laparoscopic and open inguinal hernia repair: Patient reported outcomes in the elderly from a single centre - A prospective cohort study. ( 28878892 )
2017
36
Robot-Assisted Laparoscopic Repair of Extraperitoneal Ureteral Inguinal Hernia with Mesh Placement. ( 28894843 )
2017
37
Diagnostic Laparoscopy as Decision Tool for Re-recurrent Inguinal Hernia Treatment Following Open Anterior and Laparo-Endoscopic Posterior Repair. ( 28507989 )
2017
38
Enteroscrotal Fistula in a Neonate following Incarcerated Inguinal Hernia. ( 28920031 )
2017
39
Incarcerated recurrent inguinal hernia containing an acute appendicitis (Amyand hernia): an extremely rare surgical situation. ( 28507592 )
2017
40
Rives Technique for the Primary Larger Inguinal Hernia Repair: A Prospective Study of 1000 Repairs. ( 28484818 )
2017
41
Exploring a Third Confirmed Case of Hemoperitoneum following Open Inguinal Hernia Repair Caused by Sampson Artery Hemorrhage. ( 28487804 )
2017
42
Inguinal canal spermatic cord leiomyoma presenting as an incarcerated inguinal hernia. ( 28821481 )
2017
43
An Unusual Case of Flank Pain: More Than Just an Inguinal Hernia. ( 28511774 )
2017
44
Metalloproteinases and Their Inhibitors in Patients with Inguinal Hernia. ( 28050662 )
2017
45
Fibrin glue mesh fixation under local anesthesia for the treatment of inguinal hernia in elderly patients. ( 28482651 )
2017
46
Trends of inguinal hernia repairs performed for recurrence in the United States. ( 28923698 )
2017
47
Mesh penetrating the cecum and bladder following inguinal hernia surgery: a case report. ( 28903762 )
2017
48
Postoperative urinary retention after inguinal hernia repair: a single institution experience. ( 28871414 )
2017
49
Use of fibrin glue in preventing pseudorecurrence after laparoscopic total extraperitoneal repair of large indirect inguinal hernia. ( 27617253 )
2016
50
Tumescent TAPP: laparoscopic inguinal hernia repair after the preperitoneal tumescent injection of diluted lidocaine and epinephrine saline solution and carbon dioxide gas. ( 27165268 )
2016

Variations for Inguinal Hernia

ClinVar genetic disease variations for Inguinal Hernia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FBN1 NM_000138.4(FBN1): c.840_843delTGAA (p.Asn280Lysfs) deletion Pathogenic rs1057518909 GRCh37 Chromosome 15, 48826296: 48826299

Expression for Inguinal Hernia

Search GEO for disease gene expression data for Inguinal Hernia.

Pathways for Inguinal Hernia

Pathways related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 IL6 ITGA3 MMP1 MMP13 MMP2 MMP9
2
Show member pathways
13.27 ELN FBN1 ITGA3 MMP1 MMP13 MMP2
3
Show member pathways
12.92 ELN FBN1 IL6 ITGA3 TIMP1 TIMP2
4 12.53 AR IL6 ITGA3 MMP1 MMP2 MMP9
5
Show member pathways
12.45 IL6 ITGA3 MMP2 TIMP1
6
Show member pathways
12.26 ELN FBN1 ITGA3 MMP1 MMP13 MMP2
7
Show member pathways
12.19 IL6 MMP1 MMP13 MMP9
8 12.03 IL6 MMP1 MMP2 MMP9
9
Show member pathways
11.98 AR IL6 MMP2
10 11.86 IL6 MMP1 MMP2 MMP9 TIMP1
11 11.72 MMP2 MMP9 TIMP1 TIMP2
12 11.67 AR MMP2 MMP9
13
Show member pathways
11.63 MMP1 MMP13 MMP2 MMP9 TIMP1 TIMP2
14 11.62 MMP1 MMP2 MMP9
15 11.6 IL6 ITGA3 TIMP1 TIMP2
16 11.57 MMP13 MMP2 MMP9
17 11.56 IL6 MMP2 MMP9
18
Show member pathways
11.53 IL6 MMP1 MMP2 MMP9
19 11.52 ELN IL6 MMP2 MMP9 TIMP1
20 11.39 IL6 MMP2 MMP9
21 11.36 GATA6 TBX1 TBX2
22 11.25 ELN ITGA3 MMP1 MMP9 TIMP2
23 11.2 IL6 MMP1 MMP2 MMP9
24 11.07 MMP9 TIMP1 TIMP2
25 11.05 MMP2 MMP9
26 11.03 MMP9 TIMP2
27 10.96 MMP1 MMP2
28 10.91 MMP1 TIMP1
29 10.89 MMP1 MMP13 MMP2 MMP9 TIMP1 TIMP2
30 10.85 MMP1 MMP9

GO Terms for Inguinal Hernia

Cellular components related to Inguinal Hernia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ADAMTS6 ELN FBN1 IL6 MMP1 MMP13
2 extracellular space GO:0005615 9.8 FBN1 IL6 MMP13 MMP2 MMP9 TIMP1
3 extracellular matrix GO:0031012 9.5 FBN1 MMP1 MMP13 MMP2 MMP9 TIMP1
4 proteinaceous extracellular matrix GO:0005578 9.28 ADAMTS6 ELN FBN1 MMP1 MMP13 MMP2

Biological processes related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.95 ADAMTS6 MMP1 MMP13 MMP2 MMP9
2 positive regulation of cell proliferation GO:0008284 9.91 AR IL6 TBX1 TBX2 TIMP1
3 response to drug GO:0042493 9.84 GATA6 IL6 ITGA3 TIMP2
4 extracellular matrix organization GO:0030198 9.76 ELN FBN1 ITGA3 MMP9
5 response to cytokine GO:0034097 9.65 IL6 TIMP1 TIMP2
6 cardiac muscle tissue development GO:0048738 9.57 GATA6 TBX2
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.56 MMP2 MMP9
8 positive regulation of MAPK cascade GO:0043410 9.56 AR IL6 TBX1 TIMP2
9 endodermal cell differentiation GO:0035987 9.54 GATA6 MMP2 MMP9
10 aorta morphogenesis GO:0035909 9.52 TBX1 TBX2
11 outflow tract septum morphogenesis GO:0003148 9.5 GATA6 TBX1 TBX2
12 cellular protein metabolic process GO:0044267 9.5 FBN1 GATA6 IL6 MMP1 MMP13 MMP2
13 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.49 TIMP1 TIMP2
14 collagen catabolic process GO:0030574 9.46 MMP1 MMP13 MMP2 MMP9
15 animal organ formation GO:0048645 9.43 AR GATA6
16 negative regulation of metallopeptidase activity GO:1905049 9.4 TIMP1 TIMP2
17 extracellular matrix disassembly GO:0022617 9.23 ELN FBN1 MMP1 MMP13 MMP2 MMP9

Molecular functions related to Inguinal Hernia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.77 ADAMTS6 MMP1 MMP13 MMP2 MMP9
2 serine-type endopeptidase activity GO:0004252 9.71 MMP1 MMP13 MMP2 MMP9
3 integrin binding GO:0005178 9.63 FBN1 ITGA3 TIMP2
4 protease binding GO:0002020 9.61 ITGA3 TIMP1 TIMP2
5 metallopeptidase activity GO:0008237 9.55 ADAMTS6 MMP1 MMP13 MMP2 MMP9
6 metalloendopeptidase inhibitor activity GO:0008191 9.48 TIMP1 TIMP2
7 collagen binding GO:0005518 9.43 ITGA3 MMP13 MMP9
8 metalloendopeptidase activity GO:0004222 9.35 ADAMTS6 MMP1 MMP13 MMP2 MMP9
9 zinc ion binding GO:0008270 9.17 ADAMTS6 AR GATA6 MMP1 MMP13 MMP2
10 metal ion binding GO:0046872 10.02 ADAMTS6 AR GATA6 ITGA3 MMP1 MMP13

Sources for Inguinal Hernia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
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34 ICD10 via Orphanet
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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