MCID: ING001
MIFTS: 59

Inguinal Hernia

Categories: Gastrointestinal diseases

Aliases & Classifications for Inguinal Hernia

Summaries for Inguinal Hernia

Disease Ontology : 12 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

MalaCards based summary : Inguinal Hernia, also known as hernia, inguinal, is related to appendicitis and pneumothorax. An important gene associated with Inguinal Hernia is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Dexamethasone and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and testis, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 An inguinal hernia is a protrusion of abdominal-cavity contents through the inguinal canal. Symptoms are... more...

Related Diseases for Inguinal Hernia

Diseases related to Inguinal Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 appendicitis 29.9 IL6 MMP9 TIMP1
2 pneumothorax 29.5 ELN FBN1 MMP2 MMP9
3 aortic disease 29.1 ELN FBN1 IL6 MMP2 MMP9
4 aortic aneurysm 29.0 ELN FBN1 IL6 MMP13 MMP2 MMP9
5 aortic aneurysm, familial abdominal, 1 28.4 ELN FBN1 IL6 MMP1 MMP13 MMP2
6 heart disease 28.3 ELN FBN1 IL6 TBX1 TTN
7 arthrogryposis multiplex with deafness, inguinal hernias, and early death 12.2
8 marfanoid habitus-inguinal hernia-advanced bone age syndrome 12.1
9 lambert syndrome 11.8
10 persistent mullerian duct syndrome 11.4
11 pseudomyxoma peritonei 11.4
12 cutis laxa, autosomal recessive, type ia 11.2
13 short syndrome 11.2
14 achondrogenesis, type ib 11.2
15 spondylocostal dysostosis 3, autosomal recessive 11.2
16 acrofacial dysostosis, catania type 11.0
17 hyperekplexia, hereditary 1 11.0
18 spinal muscular atrophy, x-linked 2 11.0
19 aarskog-scott syndrome 11.0
20 opitz-kaveggia syndrome 11.0
21 mucopolysaccharidosis, type ii 11.0
22 bosma arhinia microphthalmia syndrome 11.0
23 testicular anomalies with or without congenital heart disease 11.0
24 2q37 deletion syndrome 11.0
25 deafness, epiphyseal dysplasia, short stature 11.0
26 ichthyosis follicularis atrichia photophobia syndrome 11.0
27 hydrocele 10.5
28 extracranial arteriovenous malformation 10.5 MMP2 MMP9
29 focal myositis 10.5 MMP2 MMP9
30 metaphyseal anadysplasia 10.5 MMP13 MMP9
31 lentigo maligna melanoma 10.4 MMP2 MMP9
32 villous adenocarcinoma 10.4 MMP2 MMP9
33 fibromatosis, gingival, 1 10.4 MMP1 MMP2
34 psammomatous meningioma 10.4 MMP2 MMP9
35 gingival hypertrophy 10.4 MMP9 TIMP2
36 episodic pain syndrome, familial, 1 10.4
37 periodontitis, chronic 10.4 IL6 MMP1
38 nodular malignant melanoma 10.4 MMP1 MMP2 TIMP2
39 parotitis 10.4 MMP2 MMP9
40 spastic entropion 10.4 MMP1 MMP2 MMP9
41 diabetic foot ulcers 10.4 IL6 MMP9
42 internal hemorrhoid 10.3 MMP1 MMP2 MMP9
43 light chain deposition disease 10.3 MMP1 MMP2 MMP9
44 chromoblastomycosis 10.3 MMP1 MMP9
45 odontogenic myxoma 10.3 MMP1 MMP2 MMP9
46 hypertensive heart disease 10.3 MMP1 MMP2 MMP9
47 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.3 ELN FBN1
48 late-onset focal dermal elastosis 10.3 ELN FBN1
49 localized scleroderma 10.3 IL6 MMP1 MMP13
50 senile ectropion 10.3 ELN MMP2 MMP9

Graphical network of the top 20 diseases related to Inguinal Hernia:



Diseases related to Inguinal Hernia

Symptoms & Phenotypes for Inguinal Hernia

MGI Mouse Phenotypes related to Inguinal Hernia:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 TIMP2 TBX1 TTN TBX2 TIMP1 MMP9
2 homeostasis/metabolism MP:0005376 10.28 TIMP2 TBX1 TTN TBX2 TIMP1 MMP9
3 growth/size/body region MP:0005378 10.26 TIMP1 MMP9 TBX1 TTN MMP2 TBX2
4 hematopoietic system MP:0005397 10.16 TIMP1 MMP9 TIMP2 TBX1 MMP2 FBN1
5 immune system MP:0005387 10.14 TIMP1 MMP9 TIMP2 TBX1 TTN MMP2
6 craniofacial MP:0005382 10.04 TBX1 MMP2 TBX2 TTN FBN1 ADAMTS6
7 limbs/digits/tail MP:0005371 10.02 TBX1 TBX2 TIMP1 MMP9 ADAMTS6 GATA6
8 muscle MP:0005369 9.92 MMP9 TBX1 TTN MMP2 FBN1 GATA6
9 neoplasm MP:0002006 9.73 TIMP1 MMP9 MMP2 IL6 AR MMP1
10 normal MP:0002873 9.7 TIMP2 TBX1 TBX2 MMP2 TTN GATA6
11 respiratory system MP:0005388 9.5 TIMP1 MMP9 TBX1 MMP2 FBN1 GATA6
12 skeleton MP:0005390 9.32 MMP9 TBX1 TTN MMP2 TIMP1 ADAMTS6

Drugs & Therapeutics for Inguinal Hernia

Drugs for Inguinal Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 172)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
2
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2 59467-70-8 4192
3
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
4
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
5
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
6
Rocuronium Approved Phase 4,Phase 3 119302-91-9, 143558-00-3 441290
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
8
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 38396-39-3, 2180-92-9 2474
9
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
11
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
12
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3 76-42-6 5284603
13
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
14
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
15
Levobupivacaine Approved, Investigational Phase 4,Phase 2 27262-47-1 92253
16
Clonidine Approved Phase 4,Phase 3 4205-90-7 2803
17
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
18
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
19
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
20
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
21
Cefazolin Approved Phase 4,Phase 3 25953-19-9 33255 656510
22
Prilocaine Approved Phase 4 721-50-6 4906
23
Chloroprocaine Approved Phase 4 133-16-4 8612
24
Ondansetron Approved Phase 4 99614-02-5 4595
25
Remifentanil Approved Phase 4 132875-61-7 60815
26
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
27
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
28
Tamsulosin Approved, Investigational Phase 4,Early Phase 1 106133-20-4 129211
29
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
30
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
31
Meperidine Approved Phase 4 57-42-1 4058
32
Ketobemidone Approved, Investigational Phase 4 469-79-4 10101
33
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
34 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
35
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
36 Dexamethasone acetate Phase 4,Phase 3 1177-87-3
37 Analgesics Phase 4,Phase 3,Phase 2,Early Phase 1
38 calcium channel blockers Phase 4,Phase 3
39 glucocorticoids Phase 4,Phase 3
40 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
41 Adjuvants, Anesthesia Phase 4,Phase 3,Phase 2
42 Central Nervous System Stimulants Phase 4
43 Sodium Channel Blockers Phase 4,Phase 3
44 GABA Agents Phase 4,Phase 3,Phase 2
45 Narcotics Phase 4,Phase 3
46 Neuromuscular Agents Phase 4,Phase 3
47 Gastrointestinal Agents Phase 4,Phase 3
48 Neuromuscular Blocking Agents Phase 4,Phase 3
49 Neuromuscular Nondepolarizing Agents Phase 4,Phase 3
50 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 281)

# Name Status NCT ID Phase Drugs
1 Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair Unknown status NCT00960011 Phase 4
2 Study of Surgical Mesh for Inguinal Hernia Repair Unknown status NCT00924755 Phase 4
3 Ultrasound-guided Ilioinguinal-iliohypogastric Block for Inguinal Hernia Repair Unknown status NCT01326039 Phase 4 bupivacaine;saline
4 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
5 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
6 Rebound Hernia Repair Device Mesh Trial Unknown status NCT00968773 Phase 4
7 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
8 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
9 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
10 The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children Unknown status NCT02646709 Phase 4 Rocuronium;ketamine 1;ketamine 1.5;ketamine 2
11 Exparel Injection for Postoperative Orbital Pain Unknown status NCT02381353 Phase 4 Bupivacaine
12 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair Completed NCT01117337 Phase 4
13 Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias Completed NCT01264003 Phase 4 sefazolin
14 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
15 Strattice in Repair of Inguinal Hernias Completed NCT00681291 Phase 4
16 Efficacy Study of Tissucol/Tisseel Fibrin Sealant to Treat Inguinal Hernia Completed NCT00306839 Phase 4
17 Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery Completed NCT01521481 Phase 4
18 PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results Completed NCT00580177 Phase 4
19 Intrathecal Morphine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4 intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg;intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg;intravenous cannulation and premedication
20 Prospective Randomized Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis Completed NCT00614419 Phase 4
21 Evaluation of Dexamethasone Added to the Usual Infiltration With Bupivacaine in Inguinal Hernia Repair Mesh Completed NCT03007927 Phase 4 Bupivacaine-Dexamethasone;Bupivacaine- physiological solution
22 Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair Completed NCT01273818 Phase 4 Gentamicin and cefazolin;Cefazolin;Gentamicin
23 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4 Chloroprocaine;Marcaine
24 Parietex Progrip Study Completed NCT00827944 Phase 4
25 Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair Completed NCT01141335 Phase 4
26 Tizanidine and Pain After Herniorrhaphy Completed NCT02016443 Phase 4 Tizanidine;Placebo
27 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine Completed NCT01921231 Phase 4 Hyperbaric Prilocaine 1%;Hyperbaric bupivacaine 0.5%
28 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
29 Postoperative Effects of TAP Block Versus QLB Type 2 Block Completed NCT03126084 Phase 4 Acetaminophen;0.25% Bupivacaine;0.5% Bupivacaine+Glucose;Tramadol HCl;0.25% Bupivacaine
30 Comparison of Oral Zaldiar With Intravenous Paracetamol and Tramadol Completed NCT02389361 Phase 4 Zaldiar;Paracetamol-Tramadol
31 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
32 Ultrasound-guided Rectus Sheath Block In Children Completed NCT02291705 Phase 4 Tramadol
33 Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty Completed NCT01943760 Phase 4 tramadol;0.9% saline
34 Recovery of Bupivacaine or Bupivacaine-Lidocaine Spinal Anesthesia and Infiltration Anesthesia in Herniorrhaphy Completed NCT01548794 Phase 4
35 The Effect of Induction Technique on Postoperative Pain and Agitation Completed NCT02110745 Phase 4 Sevofluorane;Propofol
36 Comparison Of The Analgesia Obtained By Infiltration For The Joinings Of Episiotomies (Liropep) Completed NCT00727935 Phase 4 Lidocaïne;Ropivacaïne;Placebo
37 Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial Completed NCT02152592 Phase 4 PCM/Oxy1;PCM/Oxy2
38 Effects of Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair Recruiting NCT02055053 Phase 4 0.5% Bupivicaine
39 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Active, not recruiting NCT02419443 Phase 4 Gabapentin;Placebo
40 A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants Active, not recruiting NCT00756600 Phase 4 Regional Anesthesia;General Anesthesia
41 The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During Spinal Anesthesia Active, not recruiting NCT03121261 Phase 4 levobupivacaine;clonidine
42 Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair Enrolling by invitation NCT02958878 Phase 4 Tamsulosin;Placebo Oral Capsule
43 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Enrolling by invitation NCT02527083 Phase 4 Propofol;Sevoflurane;Remifentanil;Ketamine
44 Effectiveness of a Quadratus Lumborum 3 Block vs. a TAP-block for Inguinal Hernia Repair Not yet recruiting NCT03023462 Phase 4 Oksykodonhydroklorid;Ketobemidone Hydrochloride;Ondansetron and Droperidol;Ropivacaine
45 Lap TAP Block for Laparoscopic TEP Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial Unknown status NCT02632136 Phase 3 TAP Block Group;Peri-Portal Block Group
46 Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair Unknown status NCT01069055 Phase 3 Intravenous lornoxicam;Intravenous paracetamol
47 Laparoscopic Inguinal Hernia Repair in Infancy and Childhood Unknown status NCT02239185 Phase 3
48 Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain Unknown status NCT01450345 Phase 3 Pregabalin
49 A Trial of Local Anaesthesia Versus Local Anaesthesia and Conscious Sedation for Hernioplasty Unknown status NCT02444260 Phase 3 Midazolam;Intravenous Normal Saline;Bupivocaine;Lignocaine HCl
50 The Onset Time of Rocuronium in Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl

Search NIH Clinical Center for Inguinal Hernia

Cochrane evidence based reviews: hernia, inguinal

Genetic Tests for Inguinal Hernia

Genetic tests related to Inguinal Hernia:

# Genetic test Affiliating Genes
1 Inguinal Hernia 28

Anatomical Context for Inguinal Hernia

MalaCards organs/tissues related to Inguinal Hernia:

38
Colon, Testes, Testis, Prostate, Endothelial, Uterus, Ovary

Publications for Inguinal Hernia

Articles related to Inguinal Hernia:

(show top 50) (show all 387)
# Title Authors Year
1
Chronic pain, discomfort, quality of life and impact on sex life after open inguinal hernia mesh repair: an expertise-based randomized clinical trial comparing lightweight and heavyweight mesh. ( 29353339 )
2018
2
As in Real Estate, Location Is What Matters: A Case Report of Transplant Ureteral Obstruction Due to an Inguinal Hernia. ( 29372065 )
2018
3
Outcomes of surgery on patients with a clinically inapparent inguinal hernia as diagnosed by ultrasonography. ( 29380157 )
2018
4
The cumulative incidence and risk factors of postoperative inguinal hernia in patients undergoing radical prostatectomy. ( 29340839 )
2018
5
Ruptured Anastomotic Pseudoaneurysm of the Common Femoral Artery After Wrongful Diagnosis of Inguinal Hernia. ( 29448983 )
2018
6
Algorithm of Laparoscopic Technique in Pediatric Inguinal Hernia: Results from Experience of 10 Years. ( 29424624 )
2018
7
Prospective randomized study comparing single-incision laparoscopic versus multi-trocar laparoscopic totally extraperitoneal (TEP) inguinal hernia repair at 2 years. ( 29362907 )
2018
8
Fibrin glue versus staple mesh fixation in single-port laparoscopic totally extraperitoneal inguinal hernia repair: A propensity score-matched analysis. ( 29410137 )
2018
9
Ultrasound guided quadratus lumborum block for postoperative analgesia in pediatric ambulatory inguinal hernia repair. ( 29414626 )
2018
10
Trans-umbilical two-port laparoscopic suturing of the inguinal hernia defect with percutaneous assistance: a safe and efficient scarless surgery for pediatric inguinal hernia repair. ( 29417340 )
2018
11
Comment to: Pre-peritoneal local anaesthetic does not reduce post-operative pain in laparoscopic total extra-peritoneal inguinal hernia repair: double-blinded randomized controlled trial. Kulasegaran S, Rohan M, Pearless L, Hulme-Moir M. ( 29356910 )
2018
12
Erector spinae plane block for inguinal hernia repair in preterm infants. ( 29341379 )
2018
13
Do we really need a renaissance of pure tissue repair? Invited comment to: Desarda's technique versus Lichtenstein technique for the treatment of primary inguinal hernia: a systematic review and meta-analysis of randomized controlled trials. Emile S, Elfeki H. ( 29392507 )
2018
14
Transabdominal Preperitoneal (TAPP) versus Lichtenstein operation for primary inguinal hernia repair - A systematic review and meta-analysis of randomized controlled trials. ( 28490321 )
2017
15
Enteroscrotal Fistula in a Neonate following Incarcerated Inguinal Hernia. ( 28920031 )
2017
16
Diagnostic Laparoscopy as Decision Tool for Re-recurrent Inguinal Hernia Treatment Following Open Anterior and Laparo-Endoscopic Posterior Repair. ( 28507989 )
2017
17
Long-term results of the plugging method with regard to the prevention of a postoperative inguinal hernia after robot-assisted laparoscopic prostatectomy: a retrospective study. ( 28931316 )
2017
18
Fibrin glue mesh fixation under local anesthesia for the treatment of inguinal hernia in elderly patients. ( 28482651 )
2017
19
Mesh Displacement After Bilateral Inguinal Hernia Repair With No Fixation. ( 28904521 )
2017
20
Robot-Assisted Laparoscopic Repair of Extraperitoneal Ureteral Inguinal Hernia with Mesh Placement. ( 28894843 )
2017
21
Reduction of Inguinal Hernia Ureteral Entrapment. ( 28532750 )
2017
22
Migration of a ventriculoperitoneal shunt catheter through the processus vaginalis in infants: how serious inguinal hernia and hydrocele might be. ( 28616670 )
2017
23
Pubic and inguinal venous collaterals mimic inguinal hernia. ( 29423159 )
2017
24
Comparison of Spinal Anesthesia and Paravertebral Block in Inguinal Hernia Repair. ( 28928578 )
2017
25
Single-incision totally extraperitoneal inguinal hernia repair is feasible and safe in patients on antithrombotic therapy: A single-center experience of 92 procedures. ( 28516514 )
2017
26
Caution! The potential overestimated effect of prophylactic alpha-blockade for the prevention of urinary retention following primary inguinal hernia repair in a meta-analysis of randomized controlled trials. ( 28468725 )
2017
27
Approach to inguinal hernia in high-risk geriatric patients: Should it be elective or emergent? ( 28467578 )
2017
28
Trends of inguinal hernia repairs performed for recurrence in the United States. ( 28923698 )
2017
29
Incarcerated recurrent inguinal hernia containing an acute appendicitis (Amyand hernia): an extremely rare surgical situation. ( 28507592 )
2017
30
Postoperative urinary retention after inguinal hernia repair: a single institution experience. ( 28871414 )
2017
31
Inguinal canal spermatic cord leiomyoma presenting as an incarcerated inguinal hernia. ( 28821481 )
2017
32
Persistent postherniorrhaphy pain following inguinal hernia repair: A cross-sectional study of prevalence, pain characteristics, and effects on quality of life. ( 28890413 )
2017
33
A comparison of preoperative and postoperative testicular volume and blood flow in patients with inguinal hernia, hydrocele, and cord cyst: A prospective cohort study. ( 28523038 )
2017
34
Whole-exome sequencing identifies a potential TTN mutation in a multiplex family with inguinal hernia. ( 27115767 )
2017
35
Eosinophilic funiculitis initially diagnosed as irreducible inguinal hernia: A case report. ( 28437672 )
2017
36
Exploration Of The Contralateral Groin In Paediatric Inguinal Hernia Or Hydrocele Based On Ultrasound Findings - Is It Justified? ( 28712167 )
2017
37
Hernioscopy in Incarcerated Inguinal Hernia Spontaneously Reduced after General Anesthesia Induction. ( 29348992 )
2017
38
Laparoscopic recurrent inguinal hernia repair during the learning curve: it can be done? ( 28447970 )
2017
39
Is there a Place for Prebiotics in the Management of Neonatal Inguinal Hernia? A Preliminary Study. ( 28083493 )
2017
40
Concurrent Laparoscopic Hernia Repair and Cystoscopic Laser Cystolitholaxapy for Urinary Bladder Calculus Contained within a Direct Inguinal Hernia. ( 28958268 )
2017
41
Left renal failure caused by chronic obstructive uropathy due to a uretero-inguinal hernia combined with contralateral renal pelvic carcinoma: A case report. ( 29390441 )
2017
42
Inguinal hernia containing urinary bladder-A case report. ( 28923679 )
2017
43
An omental fibroma resembling a testicular tumour but presented as an irreducible inguinal hernia. ( 28852466 )
2017
44
Utility of single-incision totally extraperitoneal inguinal hernia repair with intraperitoneal inspection. ( 29359032 )
2017
45
Absorbable Meshes in Inguinal Hernia Surgery: A Systematic Review and Meta-Analysis. ( 28492358 )
2017
46
Laparoscopic and open inguinal hernia repair: Patient reported outcomes in the elderly from a single centre - A prospective cohort study. ( 28878892 )
2017
47
A Prospective Comparative Observational Study of Clinical Efficacy of Isobaric Ropivacaine 0.75% with of Isobaric Bupivacaine 0.5% Intrathecally in Elective Inguinal Hernia Repair Surgeries. ( 28928548 )
2017
48
A systematic review and meta-analysis concerning single-site laparoscopic percutaneous extraperitoneal closure for pediatric inguinal hernia and hydrocele. ( 28389795 )
2017
49
Inguinal hernia repair in day surgery: the role of MAC (Monitored Anesthesia Care) with remifentanil. ( 29442057 )
2017
50
Mesh Erosion into Sigmoid Colon after Inguinal Hernia Repair. ( 28469114 )
2017

Variations for Inguinal Hernia

ClinVar genetic disease variations for Inguinal Hernia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FBN1 NM_000138.4(FBN1): c.840_843delTGAA (p.Asn280Lysfs) deletion Pathogenic rs1057518909 GRCh37 Chromosome 15, 48826296: 48826299

Expression for Inguinal Hernia

Search GEO for disease gene expression data for Inguinal Hernia.

Pathways for Inguinal Hernia

Pathways related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 ELN FBN1 MMP1 MMP13 MMP2 MMP9
2
Show member pathways
12.93 ELN FBN1 IL6 TIMP1 TIMP2
3 12.7 AR IL6 MMP1 MMP2 MMP9
4
Show member pathways
12.43 MMP1 MMP13 MMP2 MMP9
5
Show member pathways
12.41 ELN FBN1 MMP1 MMP13 MMP2 MMP9
6
Show member pathways
12.18 IL6 MMP1 MMP13 MMP9
7
Show member pathways
12.06 ELN FBN1 MMP1 MMP13 MMP2 MMP9
8 12.03 IL6 MMP1 MMP2 MMP9
9
Show member pathways
11.99 AR IL6 MMP2
10 11.88 MMP13 MMP2 MMP9
11 11.86 IL6 MMP1 MMP2 MMP9 TIMP1
12 11.67 AR MMP2 MMP9
13 11.66 MMP13 MMP2 MMP9 TIMP1 TIMP2
14 11.62 MMP1 MMP2 MMP9
15 11.56 MMP13 MMP2 MMP9
16
Show member pathways
11.56 IL6 MMP1 MMP2 MMP9
17 11.55 IL6 MMP2 MMP9
18 11.45 ELN IL6 MMP2 MMP9 TIMP1
19
Show member pathways
11.43 MMP1 MMP13 MMP2 MMP9 TIMP1 TIMP2
20 11.39 IL6 MMP2 MMP9
21 11.36 GATA6 TBX1 TBX2
22 11.32 ELN MMP1 MMP9 TIMP2
23 11.2 IL6 MMP1 MMP2 MMP9
24 11.07 MMP9 TIMP1 TIMP2
25 11.03 MMP9 TIMP2
26 11 MMP2 MMP9
27 10.96 MMP1 MMP2
28 10.91 MMP1 TIMP1
29 10.91 ELN FBN1 IL6 TIMP1 TIMP2
30 10.89 MMP1 MMP13 MMP2 MMP9 TIMP1 TIMP2
31 10.85 MMP1 MMP9

GO Terms for Inguinal Hernia

Cellular components related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ADAMTS6 ELN FBN1 IL6 MMP1 MMP13
2 extracellular space GO:0005615 9.8 FBN1 IL6 MMP13 MMP2 MMP9 TIMP1
3 extracellular matrix GO:0031012 9.56 ELN FBN1 MMP1 MMP13 MMP2 MMP9
4 proteinaceous extracellular matrix GO:0005578 9.28 ADAMTS6 ELN FBN1 MMP1 MMP13 MMP2

Biological processes related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.91 ADAMTS6 MMP1 MMP13 MMP2 MMP9
2 positive regulation of cell proliferation GO:0008284 9.88 AR IL6 TBX1 TBX2 TIMP1
3 positive regulation of MAPK cascade GO:0043410 9.56 AR IL6 TBX1 TIMP2
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.54 MMP2 MMP9
5 endodermal cell differentiation GO:0035987 9.54 GATA6 MMP2 MMP9
6 cardiac muscle tissue development GO:0048738 9.52 GATA6 TBX2
7 outflow tract septum morphogenesis GO:0003148 9.5 GATA6 TBX1 TBX2
8 cellular protein metabolic process GO:0044267 9.5 FBN1 GATA6 IL6 MMP1 MMP13 MMP2
9 aorta morphogenesis GO:0035909 9.49 TBX1 TBX2
10 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.46 TIMP1 TIMP2
11 collagen catabolic process GO:0030574 9.46 MMP1 MMP13 MMP2 MMP9
12 animal organ formation GO:0048645 9.43 AR GATA6
13 negative regulation of metallopeptidase activity GO:1905049 9.4 TIMP1 TIMP2
14 extracellular matrix disassembly GO:0022617 9.23 ELN FBN1 MMP1 MMP13 MMP2 MMP9

Molecular functions related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.96 ADAMTS6 AR GATA6 MMP1 MMP13 MMP2
2 peptidase activity GO:0008233 9.72 ADAMTS6 MMP1 MMP13 MMP2 MMP9
3 serine-type endopeptidase activity GO:0004252 9.67 MMP1 MMP13 MMP2 MMP9
4 protease binding GO:0002020 9.58 TIMP1 TIMP2 TTN
5 metallopeptidase activity GO:0008237 9.55 ADAMTS6 MMP1 MMP13 MMP2 MMP9
6 metalloendopeptidase inhibitor activity GO:0008191 9.43 TIMP1 TIMP2
7 metalloendopeptidase activity GO:0004222 9.35 ADAMTS6 MMP1 MMP13 MMP2 MMP9
8 zinc ion binding GO:0008270 9.28 ADAMTS6 AR GATA6 MMP1 MMP13 MMP2

Sources for Inguinal Hernia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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