MCID: INH015
MIFTS: 25

Inherited Acute Myeloid Leukemia malady

Categories: Blood diseases, Rare diseases, Cancer diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Inherited Acute Myeloid Leukemia

Aliases & Descriptions for Inherited Acute Myeloid Leukemia:

Name: Inherited Acute Myeloid Leukemia 56
Pure Familial Acute Myeloid Leukemia 56
Pure Familial Aml 56
Inherited Aml 56
Familial Aml 56

Classifications:



External Ids:

Orphanet 56 ORPHA319465
ICD10 via Orphanet 34 C92.0

Summaries for Inherited Acute Myeloid Leukemia

MalaCards based summary : Inherited Acute Myeloid Leukemia, also known as pure familial acute myeloid leukemia, is related to mild canavan disease and cranioectodermal dysplasia 1. An important gene associated with Inherited Acute Myeloid Leukemia is CEBPA (CCAAT/Enhancer Binding Protein Alpha), and among its related pathways/superpathways are NF-kappaB Signaling and Glucose / Energy Metabolism. The drugs Bone Density Conservation Agents and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include myeloid.

Related Diseases for Inherited Acute Myeloid Leukemia

Symptoms & Phenotypes for Inherited Acute Myeloid Leukemia

Drugs & Therapeutics for Inherited Acute Myeloid Leukemia

Drugs for Inherited Acute Myeloid Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Bone Density Conservation Agents Phase 3
2 Calcium, Dietary Phase 3
3
Etanercept Approved, Investigational Phase 2 185243-69-0
4
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
7
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
8
Melphalan Approved Phase 2 148-82-3 4053 460612
9
Mycophenolic acid Approved Phase 2 24280-93-1 446541
10
Mycophenolate mofetil Approved, Investigational Phase 2 128794-94-5 5281078
11
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
12
Vidarabine Approved Phase 2 24356-66-9 32326 21704
13
Mechlorethamine Approved Phase 2 51-75-2 4033
14
ponatinib Approved Phase 2 943319-70-8 24826799
15
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
17 Prednisolone acetate Phase 2
18 Analgesics Phase 2
19 glucocorticoids Phase 2
20 Gastrointestinal Agents Phase 2
21 Neuroprotective Agents Phase 2
22 Analgesics, Non-Narcotic Phase 2
23 Hormone Antagonists Phase 2
24 Hormones Phase 2
25 Vaccines Phase 2
26 Peripheral Nervous System Agents Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
28 Prednisolone hemisuccinate Phase 2
29 Prednisolone phosphate Phase 2
30 Immunosuppressive Agents Phase 2
31 Protective Agents Phase 2
32 Antiemetics Phase 2
33 Anti-Inflammatory Agents Phase 2
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2
35 Methylprednisolone acetate Phase 2
36 Methylprednisolone Hemisuccinate Phase 2
37 Antirheumatic Agents Phase 2
38 Autonomic Agents Phase 2
39 Antineoplastic Agents, Hormonal Phase 2
40 Alkylating Agents Phase 2
41 Folic Acid Antagonists Phase 2
42 Nucleic Acid Synthesis Inhibitors Phase 2
43 Dermatologic Agents Phase 2
44 Vidarabine Phosphate Phase 2
45 Vitamin B Complex Phase 2
46 Anti-Bacterial Agents Phase 2
47 Anti-Infective Agents Phase 2
48 Antimetabolites Phase 2
49 Antibiotics, Antitubercular Phase 2
50 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:

(show all 13)
id Name Status NCT ID Phase
1 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3
2 Wilm's Tumor 1 (WT1) Peptide Vaccine for High Risk Hematologic Malignancy Completed NCT00433745 Phase 2
3 Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant Completed NCT00309907 Phase 2
4 PLX3397 in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) Recruiting NCT02390752 Phase 1, Phase 2
5 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2
6 Ponatinib for Advanced Medullary Thyroid Cancer Terminated NCT01838642 Phase 2
7 Human Placental-Derived Stem Cell Transplantation Recruiting NCT01586455 Phase 1
8 Prognostic Role of Minimal Residual Disease in Acute Myeloid Leukemia Completed NCT02714790
9 Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant Completed NCT00408681
10 Pre-myeloid Cancer and Bone Marrow Failure Clinic Study Recruiting NCT02958462
11 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
12 A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) Recruiting NCT01351545
13 Pilot Lenalidomide in Adult Diamond-Blackfan Anemia Patients w/ RBC Transfusion-Dependent Anemia Terminated NCT01034592

Search NIH Clinical Center for Inherited Acute Myeloid Leukemia

Genetic Tests for Inherited Acute Myeloid Leukemia

Anatomical Context for Inherited Acute Myeloid Leukemia

MalaCards organs/tissues related to Inherited Acute Myeloid Leukemia:

39
Myeloid

Publications for Inherited Acute Myeloid Leukemia

Variations for Inherited Acute Myeloid Leukemia

Expression for Inherited Acute Myeloid Leukemia

Search GEO for disease gene expression data for Inherited Acute Myeloid Leukemia.

Pathways for Inherited Acute Myeloid Leukemia

Pathways related to Inherited Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.75 CEBPA GATA2
2 11.62 CEBPA GATA2
3 11.08 CEBPA GATA2
4 10.32 CEBPA GATA2

GO Terms for Inherited Acute Myeloid Leukemia

Cellular components related to Inherited Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.62 CEBPA GATA2

Biological processes related to Inherited Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell maturation GO:0048469 8.96 CEBPA GATA2
2 embryonic placenta development GO:0001892 8.62 CEBPA GATA2

Molecular functions related to Inherited Acute Myeloid Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.16 CEBPA GATA2
2 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 8.96 CEBPA GATA2
3 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 8.62 CEBPA GATA2

Sources for Inherited Acute Myeloid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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