MCID: INH006
MIFTS: 17

Inherited Peripheral Neuropathy malady

Neuronal diseases category

Summaries for Inherited Peripheral Neuropathy

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32MalaCards
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MalaCards: Inherited Peripheral Neuropathy is related to neuropathy and charcot-marie-tooth disease. An important gene associated with Inherited Peripheral Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways is Neural Crest Differentiation. The compounds ganglioside and dihydroprogesterone have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and mortality/aging.

Aliases & Classifications for Inherited Peripheral Neuropathy

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

inherited peripheral neuropathy 42 60


Related Diseases for Inherited Peripheral Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Inherited Peripheral Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 31)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.8MPZ, HSPB8, PMP22, EGR2, GJB1
2charcot-marie-tooth disease30.0PMP22, MPZ
3tooth disease30.0GJB1, EGR2, PMP22, MPZ
4peripheral neuropathy10.6
5arthritis10.0
6rheumatoid arthritis10.0
7hereditary neuropathy with liability to pressure palsies10.0PMP22
8polyradiculoneuropathy10.0PMP22
9pelizaeus-merzbacher disease10.0MPZ
10encephalomyelitis10.0MPZ
11charcot-marie-tooth disease type 1a10.0PMP22, CMT1A
12charcot-marie-tooth disease type 1e10.0PMP22, CMT1A
13neuropathy, recurrent, with pressure palsies10.0PMP22, CMT1A
14charcot-marie-tooth neuropathy type 1a10.0MPZ, PMP22
15motor peripheral neuropathy10.0PMP22, MPZ
16demyelinating polyneuropathy10.0EGR2
17chronic inflammatory demyelinating polyradiculoneuropathy10.0MPZ, PMP22
18brachial plexus neuropathy10.0PMP22, MPZ
19diabetic neuropathy10.0MPZ, PMP22
20sensorineural hearing loss10.0PMP22, GJB1
21neuritis10.0MPZ, PMP22
22hereditary neuropathies10.0MPZ, GJB1, PMP22
23charcot-marie-tooth neuropathy type 210.0HSPB8, MPZ
24neurilemmoma10.0MPZ, PMP22
25charcot-marie-tooth neuropathy type 110.0MPZ, EGR2, PMP22
26charcot-marie-tooth disease type 4e10.0EGR2, PMP22, MPZ
27guillain-barre syndrome10.0MPZ, PMP22
28charcot-marie-tooth disease type 310.0MPZ, EGR2, PMP22, GJB1
29sensory peripheral neuropathy10.0PMP22, GJB1, MPZ, EGR2
30polyneuropathy10.0GJB1, MPZ, EGR2, PMP22
31myopathy10.0GJB1, MPZ, EGR2, PMP22, HSPB8

Graphical network of the top 20 diseases related to Inherited Peripheral Neuropathy:



Diseases related to inherited peripheral neuropathy

Clinical Features for Inherited Peripheral Neuropathy

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Drugs & Therapeutics for Inherited Peripheral Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Inherited Peripheral Neuropathy

Drug clinical trials:

Search ClinicalTrials for Inherited Peripheral Neuropathy

Search NIH Clinical Center for Inherited Peripheral Neuropathy

Search CenterWatch for Inherited Peripheral Neuropathy

Genetic Tests for Inherited Peripheral Neuropathy

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Anatomical Context for Inherited Peripheral Neuropathy

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Animal Models for Inherited Peripheral Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Inherited Peripheral Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4GJB1, CNTNAP1, MPZ, EGR2, PMP22
2MP:00107687.5GJB1, PMP22, HSPB8, EGR2, MPZ, CNTNAP1

Publications for Inherited Peripheral Neuropathy

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Genetic Variations for Inherited Peripheral Neuropathy

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Expression for genes affiliated with Inherited Peripheral Neuropathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inherited Peripheral Neuropathy

Search GEO for disease gene expression data for Inherited Peripheral Neuropathy.

Pathways for genes affiliated with Inherited Peripheral Neuropathy

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37NCBI BioSystems Database
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Pathways related to Inherited Peripheral Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7GJB1, MPZ

Compounds for genes affiliated with Inherited Peripheral Neuropathy

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Sources:
44Novoseek
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Compounds related to Inherited Peripheral Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganglioside449.7MPZ, PMP22
2dihydroprogesterone449.4MPZ, PMP22

GO Terms for genes affiliated with Inherited Peripheral Neuropathy

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Sources:
16Gene Ontology
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Biological processes related to Inherited Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system developmentGO:0074229.6EGR2, PMP22

Products for genes affiliated with Inherited Peripheral Neuropathy

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  • Antibodies
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Sources for Inherited Peripheral Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet