MCID: INN002
MIFTS: 39

Inner Ear Disease malady

Ear diseases category
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Summaries for Inner Ear Disease

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MalaCards based summary: Inner Ear Disease, also known as disorder of inner ear, is related to ischemia and meniere's disease. An important gene associated with Inner Ear Disease is COCH (cochlin), and among its related pathways are Parkin-Ubiquitin Proteasomal System pathway and Allograft rejection. The compounds delta-12-pgj2 and geranylgeranylacetone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and lung.

Aliases & Classifications for Inner Ear Disease

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Inner Ear Disease, Aliases & Descriptions:

Name: Inner Ear Disease 8
Disorder of Inner Ear 8 62
Diseases of Inner Ear 62
 
Disease of Inner Ear 8
Inner Ear Disorder 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


External Ids:

Disease Ontology8 DOID:2952
NCIt39 C27166

Related Diseases for Inner Ear Disease

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Diseases related to Inner Ear Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.1HSPA4, HSPA8
2meniere's disease30.1HSPA4, HSPA8, COCH
3autoimmune inner ear disease11.0
4vestibulocochlear dysfunction, progressive10.4
5otosclerosis10.3
6labyrinthine disease10.3
7perilymphatic fistula10.3
8acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma10.3
9malignant spiradenoma10.1
10central nervous system origin vertigo10.1
11vestibular neuronitis10.1
12mal de debarquement10.1
13idiopathic bilateral vestibulopathy10.1
14crohn's disease10.1
15hypertension10.1
16sinusitis10.1
17ulcerative colitis10.1
18polyarteritis nodosa10.1
19coloboma10.1
20cogan syndrome10.1
21central nervous system vasculitis10.1
22colitis10.1
23glomerulosclerosis10.1
24labyrinthitis10.1
25pertussis10.1
26vasculitis10.1
27auditory system disease10.0HSPA4, HSPA8
28oral lichen planus10.0HSPA8, HSPA4
29brain ischemia10.0HSPA4, HSPA8
30stroke, ischemic10.0HSPA8, HSPA4
31cervical cancer10.0HSPA4, HSPA8
32influenza10.0HSPA8, HSPA4
33chronic myeloid leukemia10.0HSPA8, HSPA4
34coronary artery anomaly10.0HSPA8, HSPA4
35hepatitis b10.0HSPA8, HSPA4
36malaria10.0HSPA8, HSPA4
37inflammatory bowel disease10.0HSPA8, HSPA4
38sensorineural hearing loss10.0COCH, HSPA8
39type 2 diabetes mellitus10.0HSPA4, HSPA8
40tuberculosis10.0HSPA8, HSPA4
41congenital heart disease10.0HSPA4, HSPA8
42cerebrovascular disease9.9HSPA4, HSPA8
43ovarian cancer9.9HSPA8, HSPA4
44colonic benign neoplasm9.9HSPA4, HSPA8
45asthma9.9HSPA8, HSPA4
46hypersensitivity reaction type ii disease9.8HSPA8, HSPA4
47schizophrenia9.8HSPA4, HSPA8

Graphical network of the top 20 diseases related to Inner Ear Disease:



Diseases related to inner ear disease

Symptoms for Inner Ear Disease

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Drugs & Therapeutics for Inner Ear Disease

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Drug clinical trials:

Search ClinicalTrials for Inner Ear Disease

Search NIH Clinical Center for Inner Ear Disease

Genetic Tests for Inner Ear Disease

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Anatomical Context for Inner Ear Disease

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MalaCards organs/tissues related to Inner Ear Disease:

32
Testes, Bone, Lung

Animal Models for Inner Ear Disease or affiliated genes

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Publications for Inner Ear Disease

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Articles related to Inner Ear Disease:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease. (25133431)
2014
2
An open label study to evaluate the safety and efficacy of intratympanic golimumab therapy in patients with autoimmune inner ear disease. (25203561)
2014
3
New prospects in the diagnosis and treatment of immune-mediated inner ear disease. (25332908)
2014
4
The role of intracochlear drug delivery devices in the management of inner ear disease. (25347140)
2014
5
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease. (23912888)
2013
6
Autoimmune inner ear disease: a retrospective review of forty-seven patients. (23817208)
2013
7
Review of the biologic agents used for immune-mediated inner ear disease. (22770424)
2013
8
Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatments. (23800807)
2013
9
Infliximab for autoimmune inner ear disease: case report and literature review. (24125068)
2013
10
Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research. (21251965)
2011
11
A pilot study of rituximab in immune-mediated inner ear disease. (20980741)
2011
12
Drug delivery for treatment of inner ear disease: current state of knowledge. (19952751)
2010
13
Dr. Takeda's research on MAcniA"re disease and inner ear disease. Preface. (20185942)
2010
14
Benign paroxysmal positional vertigo secondary to inner ear disease. (20723780)
2010
15
Cochlear implantation outcomes in patients with autoimmune and immune-mediated inner ear disease. (20729775)
2010
16
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. (19395984)
2009
17
Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. (19365153)
2009
18
Immune-mediated inner ear disease. (16923703)
2006
19
Alternatives to systemic steroid therapy for refractory immune-mediated inner ear disease: A physiopathologic approach. (16802138)
2006
20
Spin control: caring for a patient with inner ear disease. (16670600)
2006
21
Immune-mediated inner ear disease: 10-year experience. (15505770)
2004
22
Autoimmune inner ear disease. (15377956)
2004
23
Sudden presentation of immune-mediated inner ear disease: characterization and acceptance of a cochleovestibular dysfunction. (14653918)
2003
24
Treatment of vascular inner ear disease with pentoxifylline: a 4-week, controlled, randomized trial. (11865830)
2002
25
Validity of the Western blot immunoassay for heat shock protein-70 in associated and isolated immunorelated inner ear disease. (11889388)
2002
26
Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease. (11913688)
2002
27
Autoimmune inner ear disease: diagnostic and advanced treatments. (12528256)
2002
28
COCH5B2 is a target antigen of anti-inner ear antibodies in autoimmune inner ear diseases. (11568667)
2001
29
Autoimmune inner ear disease: steroid and cytotoxic drug therapy. (11816893)
2001
30
Identification of beta-actin as a candidate autoantigen in autoimmune inner ear disease. (11122295)
2000
31
Unusual and instructive case of immune-mediated inner ear disease associated with central nervous system vasculitis. (10629494)
2000
32
Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease. (10673153)
1999
33
Plasmapheresis in autoimmune inner ear disease: long-term follow-up. (9303152)
1997
34
You're the flight surgeon: autoimmune inner ear disease. (9441590)
1997
35
Pathophysiological mechanisms in immune inner ear disease. (9107353)
1997
36
Autoantibodies in inner ear disease. (9288203)
1997
37
Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease. (8583855)
1996
38
Myelin protein Po as a potential autoantigen in autoimmune inner ear disease. (9002556)
1996
39
Autoimmune inner ear disease. (8649900)
1996
40
Immune-mediated inner ear disease and parvovirus B19. (7934594)
1994
41
Protein profile of human perilymph: in search of markers for the diagnosis of perilymph fistula and other inner ear disease. (8084635)
1994
42
The MRL-lpr/lpr mouse: a potential model of autoimmune inner ear disease. (8475729)
1993
43
Immune-mediated inner ear disease. (1449186)
1992
44
Autoimmune inner ear disease: fact or fantasy? (1927721)
1991
45
Autoimmune inner ear disease and ulcerative colitis. (2026952)
1991
46
Effect of anti-inflammatory drugs on collagen-induced autoimmune inner ear disease. (3281543)
1988
47
Predictive value of laboratory tests in "autoimmune" inner ear disease: preliminary report. (3702564)
1986
48
Inner ear disease characterized by rolling in C3H mice. (7451317)
1980
49
Hyperlipoproteinemia and inner ear disease. (4527831)
1974
50
Diagnosis of middle and inner ear disease in rats. (13263241)
1955

Variations for Inner Ear Disease

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Expression for genes affiliated with Inner Ear Disease

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Expression patterns in normal tissues for genes affiliated with Inner Ear Disease

Search GEO for disease gene expression data for Inner Ear Disease.

Pathways for genes affiliated with Inner Ear Disease

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Compounds for genes affiliated with Inner Ear Disease

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Compounds related to Inner Ear Disease according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj2449.6HSPA4, HSPA8
2geranylgeranylacetone449.6HSPA4, HSPA8
3cyclopentenone449.6HSPA4, HSPA8
4cdcl2449.6HSPA8, HSPA4
5phenylbutyrate449.6HSPA4, HSPA8
68-oxo-dg449.6HSPA4, HSPA8
7manumycin449.6HSPA8, HSPA4
8radicicol44 61 1111.6HSPA4, HSPA8
917-(allylamino)-17-demethoxygeldanamycin449.6HSPA4, HSPA8
10sodium arsenite449.6HSPA8, HSPA4
113-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.6HSPA4, HSPA8
12rotenone449.6HSPA4, HSPA8
13manganese superoxide449.6HSPA8, HSPA4
14salicylic acid44 2810.5HSPA4, HSPA8
15cadmium44 2410.5HSPA4, HSPA8
164-hydroxynonenal44 2410.5HSPA8, HSPA4
17silver449.5HSPA8, HSPA4
18adpribose449.5HSPA4, HSPA8
19geldanamycin44 50 61 1112.5HSPA4, HSPA8
20alpha tocopherol449.5HSPA8, HSPA4
21sodium nitroprusside449.5HSPA4, HSPA8
22mannitol44 1110.5HSPA4, HSPA8
23adriamycin449.5HSPA8, HSPA4
24mg 13244 6110.5HSPA4, HSPA8
25agarose449.5HSPA4, HSPA8
26herbimycin a44 6110.5HSPA8, HSPA4
27quercetin44 61 24 1112.5HSPA4, HSPA8
28curcumin449.5HSPA4, HSPA8
29arsenite44 2410.5HSPA8, HSPA4
30prostaglandin449.5HSPA4, HSPA8
31glycerol44 24 1111.5HSPA4, HSPA8
32polyacrylamide449.5HSPA8, HSPA4
33n acetylcysteine449.5HSPA4, HSPA8
34butyrate449.4HSPA4, HSPA8
35methionine449.4HSPA8, HSPA4
36nmda44 2810.4HSPA4, HSPA8
37acetylcholine44 50 28 24 1113.4HSPA4, HSPA8
38doxorubicin44 50 1111.4HSPA8, HSPA4
39potassium44 24 1111.4HSPA4, HSPA8
40paraffin449.4HSPA4, HSPA8
41glutamine449.4HSPA8, HSPA4
42iron44 2410.3HSPA4, HSPA8
43hydrogen44 2410.3HSPA4, HSPA8
44fatty acid449.3HSPA8, HSPA4
45lactate449.2HSPA4, HSPA8
46dopamine44 28 24 1112.2HSPA4, HSPA8
47superoxide44 2410.1HSPA8, HSPA4
48heparin44 28 24 1112.1HSPA4, HSPA8
49sodium44 2410.0HSPA4, HSPA8
50creatinine448.8HSPA4, HSPA8

GO Terms for genes affiliated with Inner Ear Disease

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Biological processes related to Inner Ear Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to unfolded proteinGO:0069869.1HSPA4, HSPA8

Products for genes affiliated with Inner Ear Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Inner Ear Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet