MCID: INN002
MIFTS: 23

Inner Ear Disease malady

Ear category

Summaries for Inner Ear Disease

Sources:
33MalaCards
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MalaCards: Inner Ear Disease, also known as diseases of inner ear, is related to autoimmune inner ear disease and cochlear disease. An important gene associated with Inner Ear Disease is COCH (cochlin), and among its related pathways are Regulation of degradation of wt-CFTR and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. The compounds steroid and delta-12-pgj2 have been mentioned in the context of this disorder.

Aliases & Classifications for Inner Ear Disease

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear


Aliases & Descriptions:

inner ear disease 8
diseases of inner ear 61
disorder of inner ear 8
disease of inner ear 8
inner ear disorder 8


External Ids:

Disease Ontology8 DOID:2952
NCIt40 C27166

Related Diseases for Inner Ear Disease

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Inner Ear Disease:



Diseases related to inner ear disease

Clinical Features for Inner Ear Disease

Drugs & Therapeutics for Inner Ear Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Inner Ear Disease

Drug clinical trials:

Search ClinicalTrials for Inner Ear Disease

Search NIH Clinical Center for Inner Ear Disease

Search CenterWatch for Inner Ear Disease

Genetic Tests for Inner Ear Disease

Anatomical Context for Inner Ear Disease

Animal Models for Inner Ear Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Inner Ear Disease

Genetic Variations for Inner Ear Disease

Expression for genes affiliated with Inner Ear Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inner Ear Disease

Search GEO for disease gene expression data for Inner Ear Disease.

Pathways for genes affiliated with Inner Ear Disease

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 30KEGG, 52QIAGEN, 54Reactome
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Compounds for genes affiliated with Inner Ear Disease

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB
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Compounds related to Inner Ear Disease according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1steroid4510.1FGF3
2delta-12-pgj2459.8HSPA4, HSPA8
3geranylgeranylacetone459.8HSPA4, HSPA8
4cyclopentenone459.8HSPA4, HSPA8
5cdcl2459.8HSPA4, HSPA8
68-oxo-dg459.8HSPA4, HSPA8
7phenylbutyrate459.8HSPA4, HSPA8
8manumycin459.8HSPA8, HSPA4
9radicicol45 60 1111.8HSPA4, HSPA8
1017-(allylamino)-17-demethoxygeldanamycin459.8HSPA4, HSPA8
11sodium arsenite459.8HSPA4, HSPA8
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.8HSPA4, HSPA8
13rotenone459.8HSPA4, HSPA8
14manganese superoxide459.7HSPA8, HSPA4
15salicylic acid45 2910.7HSPA4, HSPA8
16cadmium45 2410.7HSPA4, HSPA8
17bamhi459.7HSPA4, FGF3
18silver459.7HSPA8, HSPA4
194-hydroxynonenal45 2410.7HSPA8, HSPA4
20adpribose459.6HSPA4, HSPA8
21geldanamycin45 50 60 1112.6HSPA8, HSPA4
22alpha tocopherol459.5HSPA4, HSPA8
23adriamycin459.4HSPA4, HSPA8
24sodium nitroprusside459.3HSPA4, HSPA8
25mitomycin c459.2FADD, HSPA8
26mannitol45 1110.1HSPA4, HSPA8
27heparin45 29 11 2412.1FGF3, HSPA4, HSPA8
28doxorubicin45 50 1111.0HSPA8, HSPA4, FADD
29glutamine458.9HSPA8, HSPA4, FADD
30testosterone45 60 11 2411.9HSPA8, HSPA4, FADD
31cholesterol45 29 11 2411.8FADD, HSPA4, HSPA8
32vegf458.8HSPA8, HSPA4, FGF3
33oligonucleotide458.7FGF3, FADD, HSPA8

GO Terms for genes affiliated with Inner Ear Disease

Sources:
16Gene Ontology
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Biological processes related to Inner Ear Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to unfolded proteinGO:0069869.4HSPA4, HSPA8

Products for genes affiliated with Inner Ear Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inner Ear Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet