MCID: INN002
MIFTS: 38

Inner Ear Disease malady

Ear diseases category

Summaries for Inner Ear Disease

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32MalaCards
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MalaCards: Inner Ear Disease, also known as diseases of inner ear, is related to autoimmune inner ear disease and vestibulocochlear dysfunction, progressive. An important gene associated with Inner Ear Disease is COCH (cochlin), and among its related pathways are Regulation of degradation of wt-CFTR and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. The compounds steroid and delta-12-pgj2 have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and lung.

Aliases & Classifications for Inner Ear Disease

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Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

inner ear disease 8
diseases of inner ear 60
disorder of inner ear 8
disease of inner ear 8
inner ear disorder 8


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Disease Ontology8 DOID:2952
NCIt39 C27166

Related Diseases for Inner Ear Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Inner Ear Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune inner ear disease10.5
2vestibulocochlear dysfunction, progressive10.4
3cochlear disease10.3
4collagen disease10.3
5vestibular disease10.3
6otosclerosis10.3
7labyrinthine disease10.3
8perilymphatic fistula10.3
9acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma10.3
10middle ear disease10.2
11vascular disease10.2
12ischemia10.1
13malignant spiradenoma10.1
14central nervous system origin vertigo10.1
15vestibular neuronitis10.1
16meniere's disease10.1
17endolymphatic hydrops10.1
18crohn's disease10.1
19coloboma10.1
20polyarteritis nodosa10.1
21ulcerative colitis10.1
22large cell carcinoma10.1
23central nervous system disease10.1
24central nervous system vasculitis10.1
25chromosomal disease10.1
26hair disease10.1
27hypertension10.1
28labyrinthitis10.1
29lung large cell carcinoma10.1
30nervous system disease10.1
31pertussis10.1
32vasculitis10.1
33glaucoma10.0COCH
34acute leukemia10.0HSPA8
35oral cancer10.0HSPA4
36ovarian cancer10.0FGF3
37sensorineural hearing loss10.0HSPA8, COCH
38retinoblastoma10.0FGF3
39auditory system disease10.0HSPA4, HSPA8
40oral lichen planus10.0HSPA4, HSPA8
41malaria10.0HSPA8, HSPA4
42adenocarcinoma10.0FADD, HSPA8
43endometrial carcinoma10.0HSPA8, FGF3
44brain ischemia10.0HSPA8, HSPA4
45menieres disease10.0HSPA4, HSPA8, COCH
46hepatitis b10.0FADD, HSPA4, HSPA8
47malignant glioma10.0FADD, HSPA4, HSPA8
48bladder carcinoma10.0HSPA8, FADD, FGF3
49hepatocellular carcinoma10.0HSPA4, FADD, FGF3
50stomach cancer10.0FGF3, FADD, HSPA8

Graphical network of the top 20 diseases related to Inner Ear Disease:



Diseases related to inner ear disease

Clinical Features for Inner Ear Disease

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Drugs & Therapeutics for Inner Ear Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Inner Ear Disease

Drug clinical trials:

Search ClinicalTrials for Inner Ear Disease

Search NIH Clinical Center for Inner Ear Disease

Search CenterWatch for Inner Ear Disease

Genetic Tests for Inner Ear Disease

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Anatomical Context for Inner Ear Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Inner Ear Disease:

32
Testes, Bone, Lung

Animal Models for Inner Ear Disease or affiliated genes

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Publications for Inner Ear Disease

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50PubMed
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Articles related to Inner Ear Disease:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease. (23912888)
2013
2
Autoimmune inner ear disease: a retrospective review of forty-seven patients. (23817208)
2013
3
Review of the biologic agents used for immune-mediated inner ear disease. (22770424)
2013
4
Magnetic resonance imaging of the inner ear in Meniere's disease. (20713245)
2010
5
Drug delivery for treatment of inner ear disease: current state of knowledge. (19952751)
2010
6
Benign paroxysmal positional vertigo secondary to inner ear disease. (20723780)
2010
7
Inner ear involvement in Anderson-Fabry disease: long-term follow-up during enzyme replacement therapy. (20559478)
2010
8
Inner ear pathology of alpha-galactosidase A deficient mice, a model of Fabry disease. (19900774)
2010
9
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. (19395984)
2009
10
Immunosuppressive therapy for autoimmune inner ear disease. (19885385)
2009
11
Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma. (16552463)
2007
12
Immune-mediated inner ear disease. (16923703)
2006
13
Spin control: caring for a patient with inner ear disease. (16670600)
2006
14
Topical ocular drug delivery to inner ear disease and sinusitis. (17195427)
2006
15
Dexamethasone inner ear perfusion by intratympanic injection in unilateral MAcniA"re's disease: a two-year prospective, placebo-controlled, double-blind, randomized trial. (16087029)
2005
16
Etanercept treatment for autoimmune inner ear disease: results of a pilot placebo-controlled study. (16151336)
2005
17
Computed tomography of the inner ear: size of anatomical structures in the normal temporal bone and in the temporal bone of patients with MeniA"re's disease. (15824909)
2005
18
Radiology quiz case 1. Autoimmune inner ear disease (AIED). (15967892)
2005
19
Autoimmune inner ear disease: diagnostic and advanced treatments. (12528256)
2002
20
Does the serological testing really play a role in the diagnosis immune-mediated inner ear disease? (12030569)
2002
21
COCH5B2 is a target antigen of anti-inner ear antibodies in autoimmune inner ear diseases. (11568667)
2001
22
Gene-based therapy for inner ear disease. (12689447)
2001
23
Unusual and instructive case of immune-mediated inner ear disease associated with central nervous system vasculitis. (10629494)
2000
24
Sudden hearing loss and autoimmune inner ear disease. (10976497)
2000
25
Experimental autoimmune inner ear disease: an electrocochleographic and histophysiologic study. (10823474)
2000
26
Utility of laboratory testing in autoimmune inner ear disease. (10569401)
1999
27
Sulfoglucuronosyl glycolipids as putative antigens for autoimmune inner ear disease. (9628451)
1998
28
You're the flight surgeon: autoimmune inner ear disease. (9441590)
1997
29
Autoantibodies in inner ear disease. (9288203)
1997
30
Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere's disease. (9023247)
1997
31
Antibodies to 68 kd antigen--specific for inner ear disease? (9121323)
1997
32
Myelin protein Po as a potential autoantigen in autoimmune inner ear disease. (9002556)
1996
33
Autoimmune inner ear disease. (8649900)
1996
34
Detection of inner ear disease autoantibodies by immunoblotting. (7565645)
1995
35
A substrain of NZB mouse as an animal model of autoimmune inner ear disease. (7607988)
1995
36
Immune-mediated inner ear disease and parvovirus B19. (7934594)
1994
37
Laboratory diagnosis of immune inner ear disease. (8172301)
1994
38
Azathioprine in combination with steroids in the treatment of autoimmune inner-ear disease. (8112477)
1993
39
Autoimmune inner ear disease: fact or fantasy? (1927721)
1991
40
Autoimmune inner ear disease and ulcerative colitis. (2026952)
1991
41
Aberrant frequency tuning and early stereociliary derangement in genetic inner ear disease. (2316343)
1990
42
Experimental autoimmune inner ear disease. (2643744)
1989
43
Middle ear ototoxic treatment for inner ear disease. (2929339)
1989
44
Clinical diagnosis of immune inner-ear disease. (3343873)
1988
45
Antibody activity in perilymph from rats with type II collagen-induced autoimmune inner ear disease. (6435494)
1984
46
Circling syndrome and inner ear disease in mice infected intraperitoneally or intravenously with Coccidioides immitis spherule-endospore phase cultures. (6669167)
1983
47
Deterioration of the elemental composition of endolymph in genetic inner ear disease. (7425947)
1980
48
Hyperlipoproteinemia and inner ear disease. (1153211)
1975
49
Hyperlipoproteinemia and inner ear disease. (4527831)
1974
50
Unsuspected inner- and middle-ear disease associated with fatal non-aural conditions in young children. (4259943)
1972

Genetic Variations for Inner Ear Disease

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Expression for genes affiliated with Inner Ear Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inner Ear Disease

Search GEO for disease gene expression data for Inner Ear Disease.

Pathways for genes affiliated with Inner Ear Disease

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12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Inner Ear Disease

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Inner Ear Disease according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1steroid4410.1FGF3
2delta-12-pgj2449.8HSPA4, HSPA8
3geranylgeranylacetone449.8HSPA4, HSPA8
4cyclopentenone449.8HSPA4, HSPA8
5cdcl2449.8HSPA4, HSPA8
68-oxo-dg449.8HSPA4, HSPA8
7phenylbutyrate449.8HSPA4, HSPA8
8manumycin449.8HSPA8, HSPA4
9radicicol44 59 1111.8HSPA4, HSPA8
1017-(allylamino)-17-demethoxygeldanamycin449.8HSPA4, HSPA8
11sodium arsenite449.8HSPA4, HSPA8
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.8HSPA4, HSPA8
13rotenone449.8HSPA4, HSPA8
14manganese superoxide449.7HSPA8, HSPA4
15salicylic acid44 2810.7HSPA4, HSPA8
16cadmium44 2410.7HSPA4, HSPA8
17bamhi449.7HSPA4, FGF3
18silver449.7HSPA8, HSPA4
194-hydroxynonenal44 2410.7HSPA8, HSPA4
20adpribose449.6HSPA4, HSPA8
21geldanamycin44 49 59 1112.6HSPA8, HSPA4
22alpha tocopherol449.5HSPA4, HSPA8
23adriamycin449.4HSPA4, HSPA8
24sodium nitroprusside449.3HSPA4, HSPA8
25mitomycin c449.2FADD, HSPA8
26mannitol44 1110.1HSPA4, HSPA8
27heparin44 28 11 2412.1FGF3, HSPA4, HSPA8
28doxorubicin44 49 1111.0HSPA8, HSPA4, FADD
29glutamine448.9HSPA8, HSPA4, FADD
30testosterone44 59 11 2411.9HSPA8, HSPA4, FADD
31cholesterol44 28 11 2411.8FADD, HSPA4, HSPA8
32vegf448.8HSPA8, HSPA4, FGF3
33oligonucleotide448.7FGF3, FADD, HSPA8

GO Terms for genes affiliated with Inner Ear Disease

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16Gene Ontology
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Biological processes related to Inner Ear Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to unfolded proteinGO:0069869.4HSPA4, HSPA8

Products for genes affiliated with Inner Ear Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inner Ear Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet