Aliases & Classifications for Inner Ear Disease

Aliases & Descriptions for Inner Ear Disease:

Name: Inner Ear Disease 12 14
Labyrinthine Dysfunction 12 14 69
Labyrinthine Disorder 69
Diseases of Inner Ear 69
Labyrinthine Disease 12
Labyrinth Diseases 42

Classifications:



Summaries for Inner Ear Disease

MalaCards based summary : Inner Ear Disease, also known as labyrinthine dysfunction, is related to autoimmune inner ear disease and unilateral hyperactive labyrinth, and has symptoms including earache and vertigo. An important gene associated with Inner Ear Disease is FGF3 (Fibroblast Growth Factor 3), and among its related pathways/superpathways are Gap junction trafficking and Rheumatoid arthritis. The drugs Cisplatin and Betahistine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are homeostasis/metabolism and hearing/vestibular/ear

Wikipedia : 71 The inner ear (internal ear, auris interna) is the innermost part of the vertebrate ear. In vertebrates,... more...

Related Diseases for Inner Ear Disease

Diseases related to Inner Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
id Related Disease Score Top Affiliating Genes
1 autoimmune inner ear disease 12.3
2 unilateral hyperactive labyrinth 11.1
3 bilateral hypoactive labyrinth 11.1
4 bilateral hyperactive labyrinth 11.1
5 unilateral hypoactive labyrinth 10.9
6 dnase1-related susceptibility to systemic lupus erythematosus 10.3 GJB2 GJB6
7 down syndrome-related congenital heart disease 10.3 GJB2 GJB6
8 autosomal dominant charcot-marie-tooth disease type 2 with giant axons 10.3 MPO TNF
9 fitzsimmons-guilbert syndrome 10.3 FADD FGF3
10 spastic ataxia, charlevoix-saguenay type 10.3 GJB2 GJB6
11 pik3ca-related segmental overgrowth 10.3 GJB2 GJB6
12 bietti crystalline corneoretinal dystrophy 10.3 GJB2 GJB6
13 pink1 type of young-onset parkinson disease 10.3 GJB2 GJB3 GJB6
14 primary ciliary dyskinesia 10.3 B2M FADD TNF
15 keratoderma, palmoplantar, with deafness 10.3 GJB2 GJB3 GJB6
16 hereditary thrombocytosis with transverse limb defect 10.3 GJB2 GJB3
17 klumpke paralysis 10.3 GJB2 GJB3 GJB6
18 pseudomyotonia 10.3 GJB2 GJB3 GJB6
19 autism susceptibility 17 10.3 FGF3 GJB2 MYO7A
20 orofacial cleft 10.3 COCH GJB2 KCNQ4
21 erythrokeratodermia variabilis et progressiva 10.2 GJB2 GJB3 GJB6
22 ullrich congenital muscular dystrophy 2 10.2 COCH MYH9 MYO7A
23 sturge-weber syndrome, somatic, mosaic 10.2 GJB2 MT-RNR1 SLC26A4
24 laryngitis 10.2 COCH RTEL1 SLC26A4
25 congenital herpes simplex 10.2 GJB2 GJB6 MT-RNR1
26 dementia, familial british 10.2 GJB2 GJB3 GJB6
27 spondylometaphyseal dysplasia east-african type 10.2 B2M TNF
28 panic disorder 3 10.2 CDH23 GJB2 SLC26A4
29 fibrochondrogenesis 2 10.2 COCH GJB2 MYO7A SLC26A4
30 deafness, autosomal dominant 2a 10.2 COCH GJB2 GJB6 KCNQ4
31 die smulders droog van dijk syndrome 10.2 GJB2 GJB3 GJB6 MYO7A
32 meigel disease 10.2 ATP6V0A4 ATP6V1B1
33 hereditary colorectal cancer 10.2 GJB2 KCNQ4
34 autoimmune gastrointestinal dysmotility 10.2 GJB2 GJB6 MT-RNR1
35 solitary bone cyst 10.2 GJB2 GJB3 GJB6 TNF
36 biliary cirrhosis, primary, 2 10.2 B2M MPO TNF
37 manitoba oculotrichoanal syndrome 10.2 CDH23 MYO7A SLC26A4
38 sjogren-larsson syndrome 10.2 CDH23 MYO7A SLC26A4
39 cataract 38, autosomal recessive 10.2 ATP6V0A4 ATP6V1B1
40 efemp2-related cutis laxa 10.1 CDH23 GJB2 MT-RNR1
41 bartter syndrome, type 1 10.1 COCH GJB2 GJB6 MYO7A SLC26A4
42 familial nephrotic syndrome 10.1 COL4A5 MYH9 TNF
43 charcot-marie-tooth disease, type 1d 10.1 CDH23 GJB2 MYO7A SLC26A4
44 cataract 26, multiple types 10.1 GJB2 MT-RNR1
45 deafness, autosomal recessive 23 10.1 CDH23 GJB2 MYO7A SLC26A4
46 mirizzi syndrome 10.1 MPO TNF
47 molluscum contagiosum 10.1 GJB2 GJB3 GJB6 MT-RNR1 SLC26A4
48 omenn syndrome 10.1 GJB2 MT-RNR1 MYH9 MYO7A SLC26A4
49 qazi markouizos syndrome 10.1 ATP6V0A4 ATP6V1B1 SLC19A2 SLC26A4
50 autosomal dominant nonsyndromic deafness 69 10.1 CDH23 COCH GJB2 MYO7A SLC26A4

Comorbidity relations with Inner Ear Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease
Labyrinthitis Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Inner Ear Disease:



Diseases related to Inner Ear Disease

Symptoms & Phenotypes for Inner Ear Disease

UMLS symptoms related to Inner Ear Disease:


earache, vertigo

MGI Mouse Phenotypes related to Inner Ear Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.16 ATP6V0A4 ATP6V1B1 B2M CDH23 COL4A5 FADD
2 hearing/vestibular/ear MP:0005377 10.1 ATP6V0A4 ATP6V1B1 CDH23 COCH FGF3 GJB2
3 cardiovascular system MP:0005385 10.07 B2M COL4A5 FADD GJB2 GJB3 GJB6
4 immune system MP:0005387 9.93 B2M COL4A5 FADD FGF3 GJB2 GJB3
5 nervous system MP:0003631 9.77 CDH23 FADD FGF3 GJB2 GJB6 KCNQ4
6 no phenotypic analysis MP:0003012 9.23 FADD FGF3 GJB2 GJB6 MYH9 MYO7A

Drugs & Therapeutics for Inner Ear Disease

Drugs for Inner Ear Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 282)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 1,Phase 2 15663-27-1 84093 441203 2767
2
Betahistine Approved Phase 4 5638-76-6 2366
3
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
4
Dimenhydrinate Approved Phase 4,Phase 3 523-87-5 441281
5 Piracetam Approved Phase 4 7491-74-9
6
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
7
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
8
Ethanol Approved Phase 4 64-17-5 702
9
Glycerol Approved, Experimental Phase 4 56-81-5 753
10
Phenol Approved, Experimental Phase 4 108-95-2 996
11
Thymol Approved Phase 4 89-83-8 6989
12
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
14
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
15
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
16
Pantoprazole Approved Phase 4 102625-70-7 4679
17
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
18
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
19
Ondansetron Approved Phase 4 99614-02-5 4595
20
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
21
Calcium carbonate Approved Phase 4 471-34-1
22
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
23
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
24
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
26
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
27
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
28
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
29
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
30
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
31 Anticoagulants Phase 4
32 Antimetabolites Phase 4,Phase 3
33 Fibrinolytic Agents Phase 4
34 Glucuronyl glucosamine glycan sulfate Phase 4
35 Hypoglycemic Agents Phase 4
36 Hypolipidemic Agents Phase 4
37 Lipid Regulating Agents Phase 4
38 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2
39 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
40 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
42 Antiviral Agents Phase 4,Phase 2,Phase 3
43 Analgesics Phase 4,Phase 2,Phase 1
44 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2
45 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
46 Antacids Phase 4,Phase 2,Phase 3,Phase 1
47 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Phase 1
48
Proton pump inhibitors Phase 4,Phase 2,Phase 3,Phase 1
49
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
50 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 333)
id Name Status NCT ID Phase
1 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4
2 NIMIP: Non Invasive Measurement of the Intracranial Pressure Unknown status NCT01685450 Phase 4
3 Evaluation of the Effectiveness of Bone-anchored Hearing Aids (Baha) Unknown status NCT01264510 Phase 4
4 Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy Completed NCT00160238 Phase 4
5 Efficacy of Local Overpressure Treatment for Meniere's Disease Completed NCT00831688 Phase 4
6 Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace Tablets Completed NCT02718846 Phase 4
7 Effect of Caffeine Intake in Vestibular Function Completed NCT02825199 Phase 4
8 Effect of Stellate Ganglion Block on Meniere's Disease Completed NCT01574313 Phase 4
9 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo Completed NCT01890538 Phase 4
10 Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo Completed NCT02253524 Phase 4
11 Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal Completed NCT00765635 Phase 4
12 Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis Completed NCT00525551 Phase 4
13 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4
14 NIMI-NICU: Non Invasive Monitoring of the Intracranial Pressure - NeuroIntensive Care Unit Completed NCT01685476 Phase 4
15 The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea Completed NCT02062333 Phase 4
16 Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea Completed NCT00307944 Phase 4
17 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
18 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease Recruiting NCT02530931 Phase 4
19 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4
20 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4
21 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Recruiting NCT02031692 Phase 4
22 Comparative Study of Superficial Cervical Plexus Block and Nerve of Arnold Block and Incidence of PONV for Inner Ear Surgery Recruiting NCT02724033 Phase 4
23 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4
24 A Study To Evaluate The Efficacy And Safety Of Betahistine Mesilate In The Treatment Of Patients With Vertigo Caused By Cerebral Infarction In Posterior Circulation Withdrawn NCT00474409 Phase 4
25 Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease Unknown status NCT01729767 Phase 2, Phase 3
26 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417 Phase 2, Phase 3
27 Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation Unknown status NCT00789061 Phase 2, Phase 3
28 Conventional Versus Virtual Reality Based Vestibular Rehabilitation Completed NCT01442623 Phase 2, Phase 3
29 Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease Completed NCT00802529 Phase 2, Phase 3
30 Clinical Trial of Traditional Chinese Diaoshi Jifa Therapy of Meniere's Disease Completed NCT01454726 Phase 3
31 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
32 Promethazine vs. Lorazepam for Treatment of Vertigo Completed NCT01827293 Phase 3
33 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
34 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
35 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
36 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
37 Balance Training in Parkinson's Disease Using Cues Completed NCT01960985 Phase 3
38 Sudden Deafness Treatment Trial Completed NCT00097448 Phase 3
39 AM-101 in the Treatment of Acute Tinnitus 2 Completed NCT01803646 Phase 3
40 Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With Sudden Hearing Loss Completed NCT00335920 Phase 3
41 Tinnitus Retraining Therapy Trial Completed NCT01177137 Phase 3
42 Efficacy, Safety and Immunogenicity Study of Recombinant Human C1 Inhibitor for the Treatment of Acute HAE Attacks Completed NCT01188564 Phase 3
43 A Phase3 Study to Evaluate the Efficacy and Safety of MEDI3250 in Healthy Japanese Children Age 7 Years Through 18 Years Completed NCT02269475 Phase 3
44 US Clinical Study of the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System to Treat Obstructive Sleep Apnea Completed NCT01211444 Phase 2, Phase 3
45 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Recruiting NCT02717442 Phase 3
46 Study of Lamotrigine to Treat Ménière's Disease Recruiting NCT02158585 Phase 3
47 Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) in Control of Acute Vertigo Symptoms From Peripheral Origin Recruiting NCT02112578 Phase 3
48 Rizatriptan for Episodic Dizziness in Vestibular Migraine Recruiting NCT02447991 Phase 2, Phase 3
49 AM-111 in the Treatment of Acute Inner Ear Hearing Loss Recruiting NCT02561091 Phase 3
50 Cochleural Alternating Acoustic Beam Therapy (CAABT) Versus Masking Intervention for Tinnitus Recruiting NCT02774122 Phase 3

Search NIH Clinical Center for Inner Ear Disease

Cochrane evidence based reviews: labyrinth diseases

Genetic Tests for Inner Ear Disease

Anatomical Context for Inner Ear Disease

MalaCards organs/tissues related to Inner Ear Disease:

39
Bone, Testes, Lung

Publications for Inner Ear Disease

Articles related to Inner Ear Disease:

(show top 50) (show all 127)
id Title Authors Year
1
Autoimmune inner ear disease in a melanoma patient treated with pembrolizumab. ( 26885370 )
2016
2
Chronic cerebrospinal venous insufficiency as a cause of inner ear diseases. ( 27846752 )
2016
3
Paraneoplastic syndrome: a masquerade of autoimmune inner ear disease. ( 25427223 )
2015
4
N-Acetylcysteine attenuates tumor necrosis factor alpha levels in autoimmune inner ear disease patients. ( 26392121 )
2015
5
Current understanding of the pathogenesis of autoimmune inner ear disease: a review. ( 25847404 )
2015
6
Systematic Review of Treatments for Autoimmune Inner Ear Disease. ( 26485595 )
2015
7
Diffuse systemic sclerosis presenting as Meniere's disease-like symptoms as part of autoimmune inner ear disease. ( 26040060 )
2015
8
Progression of autoimmune inner ear disease to labyrinthitis ossificans: clinical and radiologic correlation. ( 25738715 )
2015
9
Ocular vestibular evoked myogenic potentials induced by bone-conducted vibration in patients with unilateral inner ear disease. ( 24215219 )
2014
10
IL-1I^ inhibition in autoimmune inner ear disease: can you hear me now? ( 25133418 )
2014
11
Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease. ( 25133431 )
2014
12
The role of intracochlear drug delivery devices in the management of inner ear disease. ( 25347140 )
2014
13
New prospects in the diagnosis and treatment of immune-mediated inner ear disease. ( 25332908 )
2014
14
An open label study to evaluate the safety and efficacy of intratympanic golimumab therapy in patients with autoimmune inner ear disease. ( 25203561 )
2014
15
Cochlin in autoimmune inner ear disease: Is the search for an inner ear autoantigen over? ( 25199741 )
2014
16
Cogan's syndrome: an autoimmune inner ear disease. ( 22846458 )
2013
17
Developments in delivery of medications for inner ear disease. ( 23560526 )
2013
18
Autoimmune inner ear disease: a retrospective review of forty-seven patients. ( 23817208 )
2013
19
Infliximab for autoimmune inner ear disease: case report and literature review. ( 24125068 )
2013
20
Review of the biologic agents used for immune-mediated inner ear disease. ( 22770424 )
2013
21
Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatments. ( 23800807 )
2013
22
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease. ( 23912888 )
2013
23
Spectrum of immune-mediated inner ear disease and cochlear implant results. ( 22991211 )
2012
24
Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease. ( 21774850 )
2011
25
Inner ear disease and benign paroxysmal positional vertigo: a critical review of incidence, clinical characteristics, and management. ( 21837242 )
2011
26
Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research. ( 21251965 )
2011
27
Autoimmune inner ear disease in children. ( 21178803 )
2011
28
A pilot study of rituximab in immune-mediated inner ear disease. ( 20980741 )
2011
29
High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats. ( 21366505 )
2011
30
IL-1I^ is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. ( 21199898 )
2011
31
Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach. ( 20523038 )
2011
32
Drug delivery for treatment of inner ear disease: current state of knowledge. ( 19952751 )
2010
33
Guest editorial: drug delivery for treatment of inner ear disease: current state of knowledge. ( 20215911 )
2010
34
Labyrinthitis ossificans secondary to autoimmune inner ear disease: a previously unreported condition. ( 20416474 )
2010
35
Cochlear implantation outcomes in patients with autoimmune and immune-mediated inner ear disease. ( 20729775 )
2010
36
Benign paroxysmal positional vertigo secondary to inner ear disease. ( 20723780 )
2010
37
Dr. Takeda's research on MAcniA"re disease and inner ear disease. Preface. ( 20185942 )
2010
38
Cochlear implantation in patients with autoimmune inner ear disease including cogan syndrome: a comparison with age- and sex-matched controls. ( 21082747 )
2010
39
Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. ( 19365153 )
2009
40
The diagnosis of autoimmune inner ear disease: evidence and critical pitfalls. ( 18777037 )
2009
41
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. ( 19395984 )
2009
42
Immunosuppressive therapy for autoimmune inner ear disease. ( 19885385 )
2009
43
Does the serological study for viral infection in autoimmune inner ear disease make sense? ( 18235201 )
2008
44
Autoimmune inner ear disease: clinical and laboratory findings and treatment outcome. ( 19128599 )
2008
45
A novel controlled local drug delivery system for inner ear disease. ( 18182968 )
2008
46
SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma. ( 17656375 )
2007
47
Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma. ( 16552463 )
2007
48
Alternatives to systemic steroid therapy for refractory immune-mediated inner ear disease: A physiopathologic approach. ( 16802138 )
2006
49
Topical ocular drug delivery to inner ear disease and sinusitis. ( 17195427 )
2006
50
Spin control: caring for a patient with inner ear disease. ( 16670600 )
2006

Variations for Inner Ear Disease

Expression for Inner Ear Disease

Search GEO for disease gene expression data for Inner Ear Disease.

Pathways for Inner Ear Disease

Pathways related to Inner Ear Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.12 GJB2 GJB3 GJB6
2 10.75 ATP6V0A4 ATP6V1B1 TNF
3 10.36 MPO TNF

GO Terms for Inner Ear Disease

Cellular components related to Inner Ear Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.55 ATP6V0A4 ATP6V1B1 GJB6 MYO7A SLC26A4
2 vacuolar proton-transporting V-type ATPase complex GO:0016471 9.26 ATP6V0A4 ATP6V1B1
3 gap junction GO:0005921 9.13 GJB2 GJB3 GJB6
4 connexin complex GO:0005922 8.8 GJB2 GJB3 GJB6

Biological processes related to Inner Ear Disease according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 inner ear morphogenesis GO:0042472 9.61 ATP6V1B1 KCNQ4 MYO7A
2 inner ear development GO:0048839 9.54 GJB2 GJB6 MYO7A
3 negative regulation of growth of symbiont in host GO:0044130 9.51 MPO TNF
4 actin filament-based movement GO:0030048 9.49 MYH9 MYO7A
5 sensory perception of light stimulus GO:0050953 9.48 CDH23 MYO7A
6 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 B2M FADD
7 death-inducing signaling complex assembly GO:0071550 9.4 FADD TNF
8 cell communication GO:0007154 9.33 GJB2 GJB3 GJB6
9 equilibrioception GO:0050957 9.32 CDH23 MYO7A
10 sensory perception of sound GO:0007605 9.28 ATP6V0A4 ATP6V1B1 CDH23 COCH GJB2 GJB6
11 necroptotic signaling pathway GO:0097527 9.26 FADD TNF
12 regulation of pH GO:0006885 9.13 ATP6V0A4 ATP6V1B1 SLC26A4

Molecular functions related to Inner Ear Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 actin-dependent ATPase activity GO:0030898 8.96 MYH9 MYO7A
2 gap junction channel activity GO:0005243 8.62 GJB2 GJB3

Sources for Inner Ear Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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