MCID: INN002
MIFTS: 38

Inner Ear Disease malady

Ear diseases category

Summaries for Inner Ear Disease

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32MalaCards
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MalaCards: Inner Ear Disease, also known as diseases of inner ear, is related to autoimmune inner ear disease and vestibulocochlear dysfunction, progressive. An important gene associated with Inner Ear Disease is COCH (cochlin), and among its related pathways are Regulation of degradation of wt-CFTR and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. The compounds steroid and delta-12-pgj2 have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and lung.

Aliases & Classifications for Inner Ear Disease

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Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

inner ear disease 8
diseases of inner ear 60
disorder of inner ear 8
disease of inner ear 8
inner ear disorder 8


External Ids:

Disease Ontology8 DOID:2952
NCIt39 C27166

Related Diseases for Inner Ear Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Inner Ear Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune inner ear disease10.5
2vestibulocochlear dysfunction, progressive10.4
3cochlear disease10.3
4collagen disease10.3
5vestibular disease10.3
6otosclerosis10.3
7labyrinthine disease10.3
8perilymphatic fistula10.3
9acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma10.3
10middle ear disease10.2
11vascular disease10.2
12ischemia10.1
13malignant spiradenoma10.1
14central nervous system origin vertigo10.1
15vestibular neuronitis10.1
16meniere's disease10.1
17endolymphatic hydrops10.1
18crohn's disease10.1
19coloboma10.1
20polyarteritis nodosa10.1
21ulcerative colitis10.1
22large cell carcinoma10.1
23central nervous system disease10.1
24central nervous system vasculitis10.1
25chromosomal disease10.1
26hair disease10.1
27hypertension10.1
28labyrinthitis10.1
29lung large cell carcinoma10.1
30nervous system disease10.1
31pertussis10.1
32vasculitis10.1
33glaucoma10.0COCH
34acute leukemia10.0HSPA8
35oral cancer10.0HSPA4
36ovarian cancer10.0FGF3
37sensorineural hearing loss10.0HSPA8, COCH
38retinoblastoma10.0FGF3
39auditory system disease10.0HSPA4, HSPA8
40oral lichen planus10.0HSPA4, HSPA8
41malaria10.0HSPA8, HSPA4
42adenocarcinoma10.0FADD, HSPA8
43endometrial carcinoma10.0HSPA8, FGF3
44brain ischemia10.0HSPA8, HSPA4
45menieres disease10.0HSPA4, HSPA8, COCH
46hepatitis b10.0FADD, HSPA4, HSPA8
47malignant glioma10.0FADD, HSPA4, HSPA8
48bladder carcinoma10.0HSPA8, FADD, FGF3
49hepatocellular carcinoma10.0HSPA4, FADD, FGF3
50stomach cancer10.0FGF3, FADD, HSPA8

Graphical network of the top 20 diseases related to Inner Ear Disease:



Diseases related to inner ear disease

Clinical Features for Inner Ear Disease

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Drugs & Therapeutics for Inner Ear Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Inner Ear Disease

Drug clinical trials:

Search ClinicalTrials for Inner Ear Disease

Search NIH Clinical Center for Inner Ear Disease

Search CenterWatch for Inner Ear Disease

Genetic Tests for Inner Ear Disease

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Anatomical Context for Inner Ear Disease

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32MalaCards
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MalaCards organs/tissues related to Inner Ear Disease:

32
Testes, Bone, Lung

Animal Models for Inner Ear Disease or affiliated genes

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Publications for Inner Ear Disease

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Sources:
50PubMed
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Articles related to Inner Ear Disease:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatments. (23800807)
2013
2
Infliximab for autoimmune inner ear disease: case report and literature review. (24125068)
2013
3
Cogan's syndrome: an autoimmune inner ear disease. (22846458)
2013
4
Developments in delivery of medications for inner ear disease. (23560526)
2013
5
In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed MAcniA"re's disease. (22772006)
2012
6
Spectrum of immune-mediated inner ear disease and cochlear implant results. (22991211)
2012
7
Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research. (21251965)
2011
8
Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease. (21774850)
2011
9
Inner ear disease and benign paroxysmal positional vertigo: a critical review of incidence, clinical characteristics, and management. (21837242)
2011
10
IL-1I^ is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. (21199898)
2011
11
High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats. (21366505)
2011
12
Dr. Takeda's research on MAcniA"re disease and inner ear disease. Preface. (20185942)
2010
13
MRI imaging of the inner ear for Meniere's disease. (20927159)
2010
14
Cochlear implantation outcomes in patients with autoimmune and immune-mediated inner ear disease. (20729775)
2010
15
Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. (19365153)
2009
16
Does the serological study for viral infection in autoimmune inner ear disease make sense? (18235201)
2008
17
OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear. (17828551)
2007
18
Alternatives to systemic steroid therapy for refractory immune-mediated inner ear disease: A physiopathologic approach. (16802138)
2006
19
Immune-mediated inner ear disease: 10-year experience. (15505770)
2004
20
Long-term results of gentamicin inner ear perfusion in MAcniA"re's disease. (15318953)
2004
21
Sudden presentation of immune-mediated inner ear disease: characterization and acceptance of a cochleovestibular dysfunction. (14653918)
2003
22
Treatment of vascular inner ear disease with pentoxifylline: a 4-week, controlled, randomized trial. (11865830)
2002
23
Validity of the Western blot immunoassay for heat shock protein-70 in associated and isolated immunorelated inner ear disease. (11889388)
2002
24
Clinical and experimental studies of autoimmune inner ear disease. (12211349)
2002
25
Relationship between three inner ear antigens with different molecular weights and autoimmune inner ear disease. (11876599)
2002
26
Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial. (11865831)
2002
27
Autoimmune inner ear disease: steroid and cytotoxic drug therapy. (11816893)
2001
28
Identification of beta-actin as a candidate autoantigen in autoimmune inner ear disease. (11122295)
2000
29
The role of heat shock protein 70 and its autoantibody in experimental autoimmune inner ear disease]. (12768679)
2000
30
Autoimmune inner ear disease. (11123055)
2000
31
A novel method for screening anti-inner ear autoantibody in patients with autoimmune diseases]. (12768666)
2000
32
Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease. (10673153)
1999
33
Plasmapheresis in autoimmune inner ear disease: long-term follow-up. (9303152)
1997
34
Pathophysiological mechanisms in immune inner ear disease. (9107353)
1997
35
Autoimmune inner ear disease--a real entity? (9316775)
1997
36
Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease. (8583855)
1996
37
An observation on otoacoustic emission and ultrastructure of cochlea in experimental autoimmune inner ear disease. (9206068)
1996
38
Clinical evaluation and treatment of immune-mediated inner ear disease. (8935529)
1996
39
The MRL-lpr/lpr mouse: a potential model of autoimmune inner ear disease. (8475729)
1993
40
Immune-mediated inner ear disease. (1449186)
1992
41
Autoimmune inner ear disease: a review of basic mechanisms and clinical correlates. (1870168)
1991
42
Type II collagen-induced inner ear disease: critical evaluation of the guinea pig model. (2305852)
1990
43
Theoretical and practical implications for plasmapheresis in autoimmune inner ear disease. (2811552)
1989
44
Psychiatric morbidity in subjects with inner ear disease. (3180496)
1988
45
Overview of inner ear disease. (3307447)
1987
46
Practical versus theoretical management of autoimmune inner ear disease. (6374341)
1984
47
Inner ear disease characterized by rolling in C3H mice. (7451317)
1980
48
Hyperlipoproteinemias in the etiology of inner ear disease. (4702467)
1973
49
Biochemical problems of inner ear disease. (14457868)
1961
50
Diagnosis of middle and inner ear disease in rats. (13263241)
1955

Genetic Variations for Inner Ear Disease

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Expression for genes affiliated with Inner Ear Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inner Ear Disease

Search GEO for disease gene expression data for Inner Ear Disease.

Pathways for genes affiliated with Inner Ear Disease

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12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Inner Ear Disease

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Inner Ear Disease according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1steroid4410.1FGF3
2delta-12-pgj2449.8HSPA4, HSPA8
3geranylgeranylacetone449.8HSPA4, HSPA8
4cyclopentenone449.8HSPA4, HSPA8
5cdcl2449.8HSPA4, HSPA8
68-oxo-dg449.8HSPA4, HSPA8
7phenylbutyrate449.8HSPA4, HSPA8
8manumycin449.8HSPA8, HSPA4
9radicicol44 59 1111.8HSPA4, HSPA8
1017-(allylamino)-17-demethoxygeldanamycin449.8HSPA4, HSPA8
11sodium arsenite449.8HSPA4, HSPA8
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.8HSPA4, HSPA8
13rotenone449.8HSPA4, HSPA8
14manganese superoxide449.7HSPA8, HSPA4
15salicylic acid44 2810.7HSPA4, HSPA8
16cadmium44 2410.7HSPA4, HSPA8
17bamhi449.7HSPA4, FGF3
18silver449.7HSPA8, HSPA4
194-hydroxynonenal44 2410.7HSPA8, HSPA4
20adpribose449.6HSPA4, HSPA8
21geldanamycin44 49 59 1112.6HSPA8, HSPA4
22alpha tocopherol449.5HSPA4, HSPA8
23adriamycin449.4HSPA4, HSPA8
24sodium nitroprusside449.3HSPA4, HSPA8
25mitomycin c449.2FADD, HSPA8
26mannitol44 1110.1HSPA4, HSPA8
27heparin44 28 11 2412.1FGF3, HSPA4, HSPA8
28doxorubicin44 49 1111.0HSPA8, HSPA4, FADD
29glutamine448.9HSPA8, HSPA4, FADD
30testosterone44 59 11 2411.9HSPA8, HSPA4, FADD
31cholesterol44 28 11 2411.8FADD, HSPA4, HSPA8
32vegf448.8HSPA8, HSPA4, FGF3
33oligonucleotide448.7FGF3, FADD, HSPA8

GO Terms for genes affiliated with Inner Ear Disease

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16Gene Ontology
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Biological processes related to Inner Ear Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to unfolded proteinGO:0069869.4HSPA4, HSPA8

Products for genes affiliated with Inner Ear Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inner Ear Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet