MCID: INN002
MIFTS: 39

Inner Ear Disease malady

Ear diseases category
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Summaries for Inner Ear Disease

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33MalaCards
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MalaCards: Inner Ear Disease, also known as disorder of inner ear, is related to ischemia and autoimmune inner ear disease. An important gene associated with Inner Ear Disease is COCH (cochlin), and among its related pathways are Parkin-Ubiquitin Proteasomal System pathway and Allograft rejection. The compounds delta-12-pgj2 and geranylgeranylacetone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and lung.

Aliases & Classifications for Inner Ear Disease

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Sources:
8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

inner ear disease 8
disorder of inner ear 8
diseases of inner ear 62
disease of inner ear 8
inner ear disorder 8


External Ids:

Disease Ontology8 DOID:2952
NCIt40 C27166

Related Diseases for Inner Ear Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Inner Ear Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.2HSPA4, HSPA8
2autoimmune inner ear disease11.0
3vestibulocochlear dysfunction, progressive10.4
4otosclerosis10.3
5labyrinthine disease10.3
6perilymphatic fistula10.3
7acute sensorineural hearing loss by acute acoustic trauma or sudden deafness or surgery induced acoustic trauma10.3
8meniere's disease10.3
9malignant spiradenoma10.1
10central nervous system origin vertigo10.1
11vestibular neuronitis10.1
12mal de debarquement10.1
13idiopathic bilateral vestibulopathy10.1
14crohn's disease10.1
15polyarteritis nodosa10.1
16ulcerative colitis10.1
17coloboma10.1
18central nervous system vasculitis10.1
19glomerulosclerosis10.1
20hypertension10.1
21labyrinthitis10.1
22pertussis10.1
23vasculitis10.1
24cogan's syndrome10.1
25sinusitis10.1
26auditory system disease10.0HSPA4, HSPA8
27oral lichen planus10.0HSPA8, HSPA4
28brain ischemia10.0HSPA4, HSPA8
29stroke, ischemic10.0HSPA8, HSPA4
30cervical cancer10.0HSPA4, HSPA8
31influenza10.0HSPA8, HSPA4
32chronic myeloid leukemia10.0HSPA8, HSPA4
33coronary artery disease10.0HSPA8, HSPA4
34hepatitis b10.0HSPA8, HSPA4
35malaria10.0HSPA8, HSPA4
36inflammatory bowel disease10.0HSPA8, HSPA4
37sensorineural hearing loss10.0COCH, HSPA8
38type 2 diabetes mellitus10.0HSPA4, HSPA8
39tuberculosis10.0HSPA8, HSPA4
40congenital heart disease10.0HSPA4, HSPA8
41cerebrovascular disease10.0HSPA4, HSPA8
42ovarian cancer10.0HSPA8, HSPA4
43colon cancer10.0HSPA4, HSPA8
44asthma10.0HSPA8, HSPA4
45hypersensitivity reaction type ii disease10.0HSPA8, HSPA4
46menieres disease9.9HSPA4, HSPA8, COCH
47schizophrenia9.9HSPA4, HSPA8

Graphical network of the top 20 diseases related to Inner Ear Disease:



Diseases related to inner ear disease

Symptoms for Inner Ear Disease

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Drugs & Therapeutics for Inner Ear Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Inner Ear Disease

Search NIH Clinical Center for Inner Ear Disease

Genetic Tests for Inner Ear Disease

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Anatomical Context for Inner Ear Disease

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33MalaCards
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MalaCards organs/tissues related to Inner Ear Disease:

33
Testes, Bone, Lung

Animal Models for Inner Ear Disease or affiliated genes

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Publications for Inner Ear Disease

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Sources:
52PubMed
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Articles related to Inner Ear Disease:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease. (23912888)
2013
2
Autoimmune inner ear disease: a retrospective review of forty-seven patients. (23817208)
2013
3
Review of the biologic agents used for immune-mediated inner ear disease. (22770424)
2013
4
Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatments. (23800807)
2013
5
Infliximab for autoimmune inner ear disease: case report and literature review. (24125068)
2013
6
Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research. (21251965)
2011
7
A pilot study of rituximab in immune-mediated inner ear disease. (20980741)
2011
8
Drug delivery for treatment of inner ear disease: current state of knowledge. (19952751)
2010
9
Dr. Takeda's research on MAcniA"re disease and inner ear disease. Preface. (20185942)
2010
10
Benign paroxysmal positional vertigo secondary to inner ear disease. (20723780)
2010
11
Cochlear implantation outcomes in patients with autoimmune and immune-mediated inner ear disease. (20729775)
2010
12
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. (19395984)
2009
13
Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. (19365153)
2009
14
Immunosuppressive therapy for autoimmune inner ear disease. (19885385)
2009
15
Immune-mediated inner ear disease. (16923703)
2006
16
Alternatives to systemic steroid therapy for refractory immune-mediated inner ear disease: A physiopathologic approach. (16802138)
2006
17
Spin control: caring for a patient with inner ear disease. (16670600)
2006
18
Immune-mediated inner ear disease: 10-year experience. (15505770)
2004
19
Autoimmune inner ear disease. (15377956)
2004
20
Sudden presentation of immune-mediated inner ear disease: characterization and acceptance of a cochleovestibular dysfunction. (14653918)
2003
21
Treatment of vascular inner ear disease with pentoxifylline: a 4-week, controlled, randomized trial. (11865830)
2002
22
Validity of the Western blot immunoassay for heat shock protein-70 in associated and isolated immunorelated inner ear disease. (11889388)
2002
23
Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease. (11913688)
2002
24
Autoimmune inner ear disease: diagnostic and advanced treatments. (12528256)
2002
25
COCH5B2 is a target antigen of anti-inner ear antibodies in autoimmune inner ear diseases. (11568667)
2001
26
Autoimmune inner ear disease: steroid and cytotoxic drug therapy. (11816893)
2001
27
Gene-based therapy for inner ear disease. (12689447)
2001
28
Identification of beta-actin as a candidate autoantigen in autoimmune inner ear disease. (11122295)
2000
29
Unusual and instructive case of immune-mediated inner ear disease associated with central nervous system vasculitis. (10629494)
2000
30
Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease. (10673153)
1999
31
Plasmapheresis in autoimmune inner ear disease: long-term follow-up. (9303152)
1997
32
You're the flight surgeon: autoimmune inner ear disease. (9441590)
1997
33
Pathophysiological mechanisms in immune inner ear disease. (9107353)
1997
34
Autoantibodies in inner ear disease. (9288203)
1997
35
Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease. (8583855)
1996
36
Myelin protein Po as a potential autoantigen in autoimmune inner ear disease. (9002556)
1996
37
Autoimmune inner ear disease. (8649900)
1996
38
Immune-mediated inner ear disease and parvovirus B19. (7934594)
1994
39
Protein profile of human perilymph: in search of markers for the diagnosis of perilymph fistula and other inner ear disease. (8084635)
1994
40
The MRL-lpr/lpr mouse: a potential model of autoimmune inner ear disease. (8475729)
1993
41
Azathioprine in combination with steroids in the treatment of autoimmune inner-ear disease. (8112477)
1993
42
Immune-mediated inner ear disease. (1449186)
1992
43
Autoimmune inner ear disease: fact or fantasy? (1927721)
1991
44
Autoimmune inner ear disease and ulcerative colitis. (2026952)
1991
45
Effect of anti-inflammatory drugs on collagen-induced autoimmune inner ear disease. (3281543)
1988
46
Predictive value of laboratory tests in "autoimmune" inner ear disease: preliminary report. (3702564)
1986
47
Inner ear disease characterized by rolling in C3H mice. (7451317)
1980
48
Hyperlipoproteinemia and inner ear disease. (1153211)
1975
49
Hyperlipoproteinemia and inner ear disease. (4527831)
1974
50
Diagnosis of middle and inner ear disease in rats. (13263241)
1955

Variations for Inner Ear Disease

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Expression for genes affiliated with Inner Ear Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inner Ear Disease

Search GEO for disease gene expression data for Inner Ear Disease.

Pathways for genes affiliated with Inner Ear Disease

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG, 53QIAGEN
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Compounds for genes affiliated with Inner Ear Disease

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45Novoseek, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB
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Compounds related to Inner Ear Disease according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj2459.6HSPA4, HSPA8
2geranylgeranylacetone459.6HSPA4, HSPA8
3cyclopentenone459.6HSPA4, HSPA8
4cdcl2459.6HSPA8, HSPA4
5phenylbutyrate459.6HSPA4, HSPA8
68-oxo-dg459.6HSPA4, HSPA8
7manumycin459.6HSPA8, HSPA4
8radicicol45 61 1111.6HSPA4, HSPA8
917-(allylamino)-17-demethoxygeldanamycin459.6HSPA4, HSPA8
10sodium arsenite459.6HSPA8, HSPA4
113-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.6HSPA4, HSPA8
12rotenone459.6HSPA4, HSPA8
13manganese superoxide459.6HSPA8, HSPA4
14salicylic acid45 2910.5HSPA4, HSPA8
15cadmium45 2410.5HSPA4, HSPA8
164-hydroxynonenal45 2410.5HSPA8, HSPA4
17silver459.5HSPA8, HSPA4
18adpribose459.5HSPA4, HSPA8
19geldanamycin45 51 61 1112.5HSPA4, HSPA8
20alpha tocopherol459.5HSPA8, HSPA4
21sodium nitroprusside459.5HSPA4, HSPA8
22mannitol45 1110.5HSPA4, HSPA8
23adriamycin459.5HSPA8, HSPA4
24mg 13245 6110.5HSPA4, HSPA8
25agarose459.5HSPA4, HSPA8
26herbimycin a45 6110.5HSPA8, HSPA4
27quercetin45 61 24 1112.5HSPA4, HSPA8
28curcumin459.5HSPA4, HSPA8
29arsenite45 2410.5HSPA8, HSPA4
30prostaglandin459.5HSPA4, HSPA8
31glycerol45 24 1111.5HSPA4, HSPA8
32polyacrylamide459.5HSPA8, HSPA4
33n acetylcysteine459.5HSPA4, HSPA8
34butyrate459.4HSPA4, HSPA8
35methionine459.4HSPA8, HSPA4
36nmda45 2910.4HSPA4, HSPA8
37acetylcholine45 51 29 24 1113.4HSPA4, HSPA8
38doxorubicin45 51 1111.4HSPA8, HSPA4
39potassium45 24 1111.4HSPA4, HSPA8
40paraffin459.4HSPA4, HSPA8
41glutamine459.4HSPA8, HSPA4
42iron45 2410.3HSPA4, HSPA8
43hydrogen45 2410.3HSPA4, HSPA8
44fatty acid459.3HSPA8, HSPA4
45lactate459.2HSPA4, HSPA8
46dopamine45 29 24 1112.2HSPA4, HSPA8
47superoxide45 2410.1HSPA8, HSPA4
48heparin45 29 24 1112.1HSPA4, HSPA8
49sodium45 2410.0HSPA4, HSPA8
50creatinine458.8HSPA4, HSPA8

GO Terms for genes affiliated with Inner Ear Disease

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16Gene Ontology
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Biological processes related to Inner Ear Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to unfolded proteinGO:0069869.1HSPA4, HSPA8

Products for genes affiliated with Inner Ear Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Inner Ear Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet