Insensitivity to Pain malady

MalaCards: Insensitivity to Pain is related to hereditary sensory neuropathy and anhidrosis. An important gene associated with Insensitivity to Pain is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are Apoptosis and survival Role of CDK5 in neuronal death and survival and Development MAG-dependent inhibition of neurite outgrowth. The compounds gnrh and cipa have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are taste/olfaction and integument.

insensitivity to pain 7

Diseases related to insensitivity to pain by text searches and GeneDecks gene sharing:

(show top 50)    (show all 116)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary sensory neuropathy	34.7	NTRK1, NGF
2	anhidrosis	33.5	NGFR, PKLR, NGF, MAPK10, MAPK1, NTRK1
3	hereditary sensory and autonomic neuropathy type v	30.7	NTRK1, NGF, NGFR
4	pyruvate kinase deficiency	29.6	NTRK1, PKLR
5	autonomic neuropathy	29.3	NGF, NGFR, NTRK1
6	arthritis	24.9	NTRK1, CRP, MAPK10, TRPV1, NGF, NGFR
7	neuropathy	24.7	SCN9A, VIP, MAPK1, NGFR, NGF, CRP
8	neuronitis	24.3	NGFR, MAPK10, MAPK1, TRPV1, TRPM8, NTRK1
9	askin's tumor	13.4	NGF, NTRK1
10	neuroaxonal dystrophy	13.2	NTRK1, NGF
11	olfactory neuroblastoma	13.1	NTRK1, NGFR
12	ewing's family of tumors	13.0	NGF, NGFR
13	eating disorder	12.9	NTRK1, NGFR, NGF
14	burning mouth syndrome	12.9	TRPV1, NGF, SCN9A
15	adenomyosis	12.9	NTRK1, NGF, NGFR
16	aspiration pneumonia	12.9	TRPM8, CRP
17	ependymoma	12.8	NTRK1, NGF, NGFR
18	dentin sensitivity	12.8	TRPV2, TRPM8, TRPV1
19	rett syndrome	12.8	NTRK1, NGF, VIP
20	allergic asthma	12.7	NGFR, NTRK1, NGF
21	trigeminal neuralgia	12.7	SCN9A, CRP
22	hirschsprung's disease	12.7	NTRK1, VIP, NGFR
23	diabetic neuropathy	12.6	NGFR, NTRK1, NGF, TRPV1
24	ganglioneuroma	12.5	VIP, NGF, NGFR, NTRK1
25	differentiating neuroblastoma	12.4	MAPK1, NGF, NTRK1
26	cystitis	12.4	TRPV1, NGF, CRP
27	atopic dermatitis	12.4	VIP, NGF, NGFR
28	neuroma	12.3	MAPK10, NGFR, NGF, TRPV1
29	neuroepithelioma	12.3	NGF, MAPK1, MAPK10
30	papillary thyroid carcinoma	12.3	MAPK10, NTRK1, MAPK1
31	muscular dystrophy	12.2	PKLR, NGF, MAPK10, NGFR
32	bartter disease	12.2	VIP, NGFR, NGF, NTRK1
33	cerebral artery occlusion	12.2	NGF, CRP, MAPK1
34	psoriatic arthritis	12.1	NGFR, NGF, CRP
35	chagas disease	12.0	MAPK10, NTRK1, NGF, MAPK1
36	cerebral primitive neuroectodermal tumor	12.0	NTRK1, VIP, MAPK10, NGF, NGFR
37	neuroectodermal tumors	12.0	VIP, NGFR, MAPK10, NGF, NTRK1
38	brain ischemia	12.0	VIP, MAPK10, MAPK1
39	cadasil	12.0	CRP, NTRK1, MAPK10, VIP
40	small-cell cancer of lung	12.0	NTRK1, VIP, MAPK1, NGFR
41	prolactinoma	12.0	VIP, NGFR, MAPK1, NGF
42	seizures	11.9	SCN9A, MAPK10, NGF, NGFR, VIP
43	leprosy	11.9	MAPK1, CRP, NGF, NTRK1
44	polyneuropathy	11.9	NGF, MAPK1, CRP
45	adenoid cystic carcinoma	11.8	NGF, MAPK1, NTRK1
46	neurodegenerative disease	11.8	MAPK1, NGF, NGFR, NTRK1
47	down syndrome	11.7	NGF, MAPK10, VIP, CRP, NTRK1
48	prostate colloid adenocarcinoma	11.7	MAPK10, MAPK1, NGFR, NTRK1, NGF
49	malignant glioma	11.7	MAPK1, TRPV1, NGFR, NGF, NTRK1
50	spinal cord injury	11.6	MAPK10, MAPK1, CRP, NGFR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to insensitivity to pain:

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MGI Mouse Phenotypes related to insensitivity to pain:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	8.5	TRPV1, MAPK1, NGFR
2	integument phenotype	MP:0010771	8.2	NGFR, NGF, NTRK1, TRPM8, TRPV1, SCN9A
3	immune system phenotype	MP:0005387	7.4	CRP, TRPV2, TRPV1, MAPK1, PKLR, NGFR
4	nervous system phenotype	MP:0003631	6.9	SCN9A, NGFR, NGF, NTRK1, TRPM8, TRPV1
5	behavior/neurological phenotype	MP:0005386	6.4	NGF, VIP, SCN9A, MAPK10, MAPK1, TRPV1

Articles related to insensitivity to pain:

(show all 39)

id	Title	Authors	Year	Affiliating Genes
1	Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain. (20692858)	Staud R.... Wallace M.R.	2011	SCN9A
2	Congenital insensitivity to pain: novel SCN9A missens e and in-frame deletion mutations. (20635406)	Cox J.J.... Parvari R.	2010	SCN9A
3	Haploinsufficiency of the nerve growth factor beta ge ne in a 1p13 deleted female child with an insensitivity to pain. (19183217)	Fitzgibbon G.J.... Gaunt L.	2009	NGF
4	Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals wi th and without Norrbottnian congenital insensitivity to pain. (19482060)	Axelsson H.E.... Zygmunt P.M.	2009	TRPV1, VIP, TRPV2
5	Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene. (19250380)	Suriu C.... Falik-Zaccai T.C.	2009	NTRK1
6	Congenital insensitivity to pain (18808773)	Danziger N.... Willer J.C.	2009	SCN9A
7	Clinical and genetic analysis of Korean patients with congenital insensitivity to pain with anhidrosis. (19618435)	Lee S.T.... Ki C.S.	2009	NTRK1
8	Nerve growth factor, interoception, and sympathetic neuron: lesson from congenital insensitivity to pain with anhidrosis. (19201660)	Indo Y.	2009	NTRK1, NGF
9	Two novel SCN9A mutations causing insensitivity to pain. (19304393)	Nilsen K.B.... Aasly J.	2009	SCN9A
10	Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF. (19038341)	Larsson E.... Holmberg M.	2009	NGF
11	Humoral immunodeficiency in congenital insensitivity to pain with anhidrosis. (19089473)	Kilic S.S.... Timmerman V.	2009	NTRK1
12	Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. (18955016)	Beigelman A.... Levy R.	2009	NTRK1, MAPK1, MAPK10
13	Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. (18077166)	Huehne K.... Rautenstrauss B.	2008	NTRK1
14	Arthritis in a child secondary to congenital insensitivity to pain and self-aggression. Why and when pain is good? (16770519)	Emad Y.... Salama M.	2007	CRP
15	Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis. (16279365)	Schreiber R.... Hershkovitz E.	2005	NTRK1, NGF
16	Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them. (16138253)	Barone R.... Pavone P.	2005	NTRK1, NGF
17	Clinical and genetic aspects of congenital insensitivity to pain with anhidrosis (15999564)	Schwarzkopf R.... Gorzak Y.	2005	NTRK1, NGF
18	Anti-apoptotic effect of nerve growth factor is lost in congenital insensitivity to pain with anhidrosis (CIPA) B lymphocytes. (15114061)	Sato Y.... Eguchi M.	2004	NTRK1, NGF
19	Familial insensitivity to pain (HSAN V) and a mutation in the NGFB gene. A neurophysiological and pathological study. (15468048)	Minde J.... Solders G.	2004	NGF
20	The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis. (15078381)	Rozentsveig V.... Gurman G.M.	2004	NTRK1
21	A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA). (15163901)	Melamed I.... Gelfand E.W.	2004	NTRK1, NGFR
22	Congenital insensitivity to pain with anhidrosis in Taiwan: a morphometric and genetic study. (15159601)	Guo Y.C.... Lin K.P.	2004	NTRK1
23	An infant with primary tooth loss and palmar hyperkeratosis: a novel mutation in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis. (12949319)	Bonkowsky J.L.... Swoboda K.J.	2003	NTRK1
24	Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (12102460)	Indo Y.	2002	NTRK1
25	The M581V mutation, associated with a mild form of congenital insensitivity to pain with anhidrosis, causes partial inactivation of the NTRK1 receptor. (12406349)	Miranda C.... Greco A.	2002	NTRK1
26	Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurotrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations. (11719521)	Miranda C.... Greco A.	2002	NTRK1
27	Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (11748840)	Indo Y.	2001	NTRK1, NGF
28	Two novel mutant alleles of the gene encoding neurotrophic tyrosine kinase receptor type 1 (NTRK1) in a patient with congenital insensitivity to pain with anhidrosis: a splice junction mutation in intron 5 and cluster of four mutations in exon 15. (11139246)	Bodzioch M.... Schmitz G.	2001	NTRK1
29	Neurophysiologic studies in congenital insensitivity to pain with anhidrosis. (11744315)	Shorer Z.... Levy J.	2001	NTRK1
30	Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency. (11668614)	Indo Y.... Matsuda I.	2001	NTRK1, PKLR
31	Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. (11159935)	Mardy S.... Indo Y.	2001	NTRK1, NGF
32	Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families. (10982191)	Miura Y.... Indo Y.	2000	NTRK1
33	Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli- Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. (10861667)	Shatzky S.... Parvari R.	2000	NTRK1
34	The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. (10567924)	Greco A.... Pierotti M.A.	2000	NTRK1, NGF
35	Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis. (11071380)	Miura Y.... Indo Y.	2000	NTRK1
36	A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis. (10233776)	Yotsumoto S.... Kanzaki T.	1999	NTRK1
37	A novel NTRK1 mutation associated with congenital insensitivity to pain with anhidrosis. (10090906)	Greco A.... Pierotti M.A.	1999	NTRK1
38	Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. (10330344)	Mardy S.... Indo Y.	1999	NTRK1
39	Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. (8696348)	Indo Y.... Matsuda I.	1996	NTRK1, NGF

Genes related to insensitivity to pain according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.1	Summaries, Publications
2	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	11.1	Summaries, Publications
3	TRPV2	transient receptor potential cation channel, subfamily V, member 2	11.0	Publications
4	PKLR	pyruvate kinase, liver and RBC	11.0	Publications
5	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
6	TRPM8	transient receptor potential cation channel, subfamily M, member 8	11.0	Publications
7	NGFR	nerve growth factor receptor	11.0	Publications
8	TRPV1	transient receptor potential cation channel, subfamily V, member 1	11.0	Publications
9	VIP	vasoactive intestinal peptide	11.0	Publications
10	MAPK10	mitogen-activated protein kinase 10	11.0	Publications
11	MAPK1	mitogen-activated protein kinase 1	11.0	Publications
12	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to insensitivity to pain according to GeneDecks:

(show all 24)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.2	NGF, NTRK1
2	Development MAG-dependent inhibition of neurite outgrowth10	9.8	NTRK1, NGF, NGFR
3	Development_MAG-dependent inhibition of neurite outgrowth41	9.7	NTRK1, NGFR, NGF
4	Sodium channels and transporters- inward current10	9.7	SCN9A, TRPV1, TRPM8
5	NGF Pathway36	9.3	NGFR, NTRK1, MAPK1
6	Intracellular Calcium Signaling36	9.2	NTRK1, TRPV2, TRPM8, TRPV1
7	TRKA Signaling36	9.0	NTRK1, MAPK1, MAPK10
8	Type II diabetes mellitus20	9.0	PKLR, MAPK10, MAPK1
9	IL-2 Gene Expression in Activated and Quiescent T-Cells36	8.9	MAPK10, MAPK1
10	Aldosterone Signaling in Epithelial Cells36	8.9	SCN9A, MAPK1, MAPK10
11	Insulin signaling pathway20	8.8	PKLR, MAPK1, MAPK10
12	MAPK signaling pathway20	8.6	NGF, NTRK1, MAPK1, MAPK10
13	PKA Signaling36	8.6	NGFR, CRP, MAPK1, SCN9A
14	p70S6K Signaling36	8.6	MAPK10, MAPK1, NGFR, NTRK1
15	Renin-Angiotensin Pathway36	8.6	MAPK1, NGFR, NTRK1, MAPK10
16	Activation of cAMP-Dependent PKA36	8.6	NTRK1, CRP, SCN9A, MAPK1
17	Breast Cancer Regulation by Stathmin136	8.5	NTRK1, MAPK1, MAPK10, NGFR
18	cAMP Pathway36	8.5	SCN9A, MAPK1, NTRK1, NGFR, CRP
19	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.4	MAPK1, NGFR, NGF, NTRK1, MAPK10
20	Development Neurotrophin family signaling10	8.4	NGFR, NGF, NTRK1, MAPK10, MAPK1
21	Antioxidant Action of Vitamin-C36	8.4	NGFR, MAPK1, NTRK1, MAPK10
22	Development_Neurotrophin family signaling41	8.4	MAPK10, MAPK1, NTRK1, NGF, NGFR
23	Neurotrophin signaling pathway20	8.3	MAPK10, MAPK1, NGF, NGFR, NTRK1
24	MAPK Signaling36	8.1	NGFR, MAPK1, MAPK10, NTRK1

Compounds related to insensitivity to pain according to GeneDecks:

(show top 50)    (show all 90)

id	Compound	Score	Top Affiliating Genes
1	gnrh32	10.4	NTRK1
2	cipa32	10.2	NTRK1, NGF
3	ntr 36842	10.1	NGF, NGFR
4	bdnf (human)42	10.0	NGFR, NGF
5	estradiol valerate32	9.9	NGF, NGFR
6	ro 08-275042	9.9	NTRK1, NGFR, NGF
7	ppahv42 32	10.9	TRPV2, TRPV1
8	olvanil32 42	10.9	TRPV2
9	kt 582332	9.8	NTRK1, NGF, VIP
10	lidocaine32 9 9	11.7	NGF, TRPV1, SCN9A
11	ag 87932 42	10.7	MAPK10, NTRK1, NGF
12	menthol32 9 18 9	12.6	TRPM8, TRPV1
13	carrageenan32	9.6	TRPV1, SCN9A
14	ly29400232	9.5	MAPK1, CRP
15	8-(4-chlorophenylthio)-camp32	9.5	MAPK10, VIP
16	gw-507432	9.3	MAPK10, MAPK1
17	choline32 9 18 9	12.3	NGFR, VIP, NTRK1, NGF
18	1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene32	9.3	MAPK10, MAPK1
19	tetrodotoxin32	9.3	TRPV1, SCN9A, VIP
20	pyridinylimidazole32	9.3	MAPK10, MAPK1
21	olomoucine32 42 9 9	12.1	MAPK10, MAPK1, NGF
22	cyclic amp32 18	10.0	NGFR, MAPK10, NGF, NTRK1, TRPV2
23	morphine32 9 9	10.9	NGF, VIP, MAPK10, TRPV1
24	bisindolylmaleimide32	8.9	MAPK10, TRPV1, MAPK1
25	c2ceramide32	8.8	MAPK1, NGF, NTRK1, MAPK10
26	pertussis32	8.8	VIP, MAPK10, MAPK1
27	dopamine32 9 18 9	11.8	NGFR, NTRK1, TRPV1, VIP, NGF
28	phorbol32	8.7	MAPK10, MAPK1, NTRK1, NGFR
29	capsaicin32	8.7	TRPV2, TRPM8, NTRK1, NGF, VIP, TRPV1
30	matrigel32	8.6	NGFR, MAPK1, NTRK1, NGF
31	imatinib32 34 9 9	11.6	MAPK1, VIP, NTRK1, MAPK10
32	k252a32	8.5	MAPK10, MAPK1, NTRK1, NGFR, NGF
33	ceramide32	8.4	MAPK10, MAPK1, NTRK1, NGF, NGFR
34	phosphotyrosine32	8.4	NGFR, NGF, MAPK1, MAPK10, NTRK1
35	12-o-tetradecanoylphorbol 13-acetate32	8.4	NGFR, MAPK10, NGF, NTRK1, MAPK1
36	lactate32	8.4	MAPK10, CRP, NTRK1, TRPV1, VIP
37	wortmannin32 42	9.4	MAPK1, MAPK10, NTRK1, NGFR, NGF
38	phosphoinositide32	8.4	MAPK10, NGFR, MAPK1, NGF, NTRK1
39	glutamate32	8.3	NGFR, NTRK1, VIP, MAPK1, TRPV1
40	acetylcholine32 9 18 9	11.2	NTRK1, NGF, NGFR, MAPK10, VIP, CRP
41	nmda32 42	9.2	TRPV1, MAPK1, MAPK10, NGFR, NGF
42	thapsigargin32 42	9.1	MAPK1, VIP, NGF, TRPV1, MAPK10
43	thymidine32 18	9.1	VIP, NGF, NGFR, MAPK10, MAPK1
44	cycloheximide32	8.0	MAPK10, MAPK1, NTRK1, CRP, NGF
45	adenylate32	7.9	NTRK1, MAPK10, VIP, MAPK1, NGF, TRPV1
46	forskolin32 42 9 9	10.7	NGFR, TRPV1, MAPK1, MAPK10, VIP, NGF
47	vegf32	7.4	VIP, NGFR, NGF, MAPK10, MAPK1, NTRK1
48	serine32	7.1	NGF, PKLR, NGFR, NTRK1, TRPV1, MAPK1
49	tyrosine32	7.1	TRPV1, VIP, NGF, PKLR, MAPK10, NGFR
50	calcium32 9 18 9	9.3	MAPK10, MAPK1, TRPV1, TRPV2, TRPM8, NTRK1

Cellular components related to insensitivity to pain according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endosome	GO:005768	9.5	NTRK1, NGF, NGFR

Biological processes related to insensitivity to pain according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	thermoception	GO:050955	9.8	TRPM8, TRPV1
2	regulation of axonogenesis	GO:050770	9.7	NGFR, NGF
3	positive regulation of axonogenesis	GO:050772	9.6	NGFR, NGF
4	activation of MAPKK activity	GO:000186	9.2	MAPK1, NTRK1, NGF
5	Ras protein signal transduction	GO:007265	9.0	NGF, MAPK1, NTRK1
6	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	8.7	MAPK10, MAPK1
7	nerve growth factor receptor signaling pathway	GO:048011	8.7	NGFR, NGF, NTRK1, MAPK1

Molecular functions related to insensitivity to pain according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nerve growth factor binding	GO:048406	9.8	NTRK1, NGFR
2	calcium channel activity	GO:005262	9.0	TRPV1, TRPV2, TRPM8