MCID: INS006
MIFTS: 40

Insulin Autoimmune Syndrome malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Insulin Autoimmune Syndrome

Aliases & Descriptions for Insulin Autoimmune Syndrome:

Name: Insulin Autoimmune Syndrome 50 56 69
Hirata Disease 50 56
Insulin Autoimmune Hypoglycemia 50

Characteristics:

Orphanet epidemiological data:

56
insulin autoimmune syndrome
Inheritance: Not applicable; Age of onset: Adult,Elderly;

Classifications:

Orphanet: 56  
Rare endocrine diseases


External Ids:

Orphanet 56 ORPHA411593
ICD10 via Orphanet 34 E16.1

Summaries for Insulin Autoimmune Syndrome

NIH Rare Diseases : 50 insulin autoimmune syndrome is a rare condition that causes low blood sugar (hypoglycemia). this occurs because the body begins to make a specific kind of protein called antibodies to attack insulin. insulin is a naturally occurring hormone that is responsible for keeping blood sugar at a normal level. when blood sugar levels get too high, insulin helps to store the sugar for future use. people affected by insulin autoimmune syndrome have antibodies that attack insulin, causing it to work too hard and the level of blood sugar to become too low. insulin autoimmune syndrome most often begins during adulthood. last updated: 11/13/2016

MalaCards based summary : Insulin Autoimmune Syndrome, also known as hirata disease, is related to hypoglycemia and graves' disease, and has symptoms including acanthosis nigricans, weight loss and arthralgia/arthritis. An important gene associated with Insulin Autoimmune Syndrome is INS (Insulin), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells and skin.

Related Diseases for Insulin Autoimmune Syndrome

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to Insulin Autoimmune Syndrome

Symptoms & Phenotypes for Insulin Autoimmune Syndrome

Human phenotypes related to Insulin Autoimmune Syndrome:

56 32 (show all 13)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 acanthosis nigricans 56 32 Frequent (79-30%) HP:0000956
2 weight loss 56 32 Frequent (79-30%) HP:0001824
3 arthralgia/arthritis 56 32 Frequent (79-30%) HP:0005059
4 hyperinsulinemic hypoglycemia 56 32 Obligate (100%) HP:0000825
5 increased antibody level in blood 56 32 Very frequent (99-80%) HP:0010702
6 insulin-resistant diabetes mellitus 56 32 Very frequent (99-80%) HP:0000831
7 systemic lupus erythematosus 56 32 Very frequent (99-80%) HP:0002725
8 autoimmune antibody positivity 56 32 Very frequent (99-80%) HP:0030057
9 fasting hypoglycemia 56 32 Frequent (79-30%) HP:0003162
10 nonketotic hypoglycemia 56 32 Frequent (79-30%) HP:0001958
11 reactive hypoglycemia 56 32 Frequent (79-30%) HP:0012051
12 autoimmunity 56 Frequent (79-30%)
13 insulin resistance 56 Very frequent (99-80%)

Drugs & Therapeutics for Insulin Autoimmune Syndrome

Drugs for Insulin Autoimmune Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 4
2 Antirheumatic Agents Phase 4,Phase 1,Phase 2
3
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0
4
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
5 Analgesics Phase 1, Phase 2
6 Gastrointestinal Agents Phase 1, Phase 2
7 Analgesics, Non-Narcotic Phase 1, Phase 2
8 Peripheral Nervous System Agents Phase 1, Phase 2
9 Immunoglobulins Phase 2
10 Immunosuppressive Agents Phase 1, Phase 2
11 Anti-Inflammatory Agents Phase 1, Phase 2
12 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
13 Antibodies Phase 2
14 Autoantibodies Phase 1, Phase 2
15 vitamin d Phase 2
16
Secoisolariciresinol Phase 2 29388-59-8 65373
17 Trace Elements Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Ergocalciferols Phase 2
22 Vitamins Phase 2
23 Estrogens Phase 2
24 Phytoestrogens Phase 2
25 Micronutrients Phase 2
26 Bone Density Conservation Agents Phase 2
27 Pharmaceutical Solutions Phase 2
28 Antibodies, Monoclonal Phase 2
29 Vitamin D2 Nutraceutical Phase 2
30 Whey Protein Nutraceutical Phase 2
31 Flax Nutraceutical Phase 2
32 Calciferol Nutraceutical Phase 2
33
Rosiglitazone Approved, Investigational 122320-73-4 77999
34
Zinc Approved 7440-66-6 32051 23994
35
Metformin Approved 657-24-9 14219 4091
36
Insulin Aspart Approved 116094-23-6 16132418
37
Ethanol Approved 64-17-5 702
38
Aspirin Approved, Vet_approved 50-78-2 2244
39
Prednisone Approved, Vet_approved 53-03-2 5865
40
Guaifenesin Approved, Vet_approved 93-14-1 3516
41 insulin
42 Hypoglycemic Agents
43 Protamines
44 Insulin, Globin Zinc
45 Insulin aspart, insulin aspart protamine drug combination 30:70
46 Antibodies, Antiphospholipid
47 Liver Extracts
48 puerarin
49 Atorvastatin Calcium 134523-03-8
50 Chlorpheniramine, phenylpropanolamine drug combination

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4
2 Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis Not yet recruiting NCT02976688 Phase 2, Phase 3
3 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2
4 Oxidative Stress and Nutritional Supplementation Intervention Study Completed NCT01234506 Phase 2
5 Investigation of Otelixizumab in New-Onset, Autoimmune Type 1 Diabetes Mellitus Patients Active, not recruiting NCT02000817 Phase 2
6 Randomized Controlled Trial of Insulin Versus Tablets for Latent Autoimmune Diabetes in Adults (LADA) Unknown status NCT00776607
7 The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome Unknown status NCT01818505
8 The Genetics of Diabetes in Southern California Chinese Americans Unknown status NCT00824395
9 Metabolic Syndrome Feasibility Study Completed NCT02287766
10 The Role of FTO Gene Polymorphism and Insulin Preparation in Obesity in Children With Type 1 Diabetes Mellitus Completed NCT01279161
11 A Study of the Metabolic Syndrome in Patients With Systemic Lupus Erythematosus Completed NCT00982670
12 Uncovering the 'ORIGINS' of Diabetes Completed NCT02226640
13 Genetic and Environmental Risk Factors of Type 1 Autoimmune Diabetes and Its Early Complications Recruiting NCT02212522
14 Clinical Importance of Glucose Regulation in Relapsing MS Recruiting NCT03004079
15 Impact of a Nutritional Intervention on Type1 Diabetes Adult With Metabolic Syndrome Recruiting NCT02821585
16 Preservation of Residual Beta Cell Mass and Prevention of Celiac Disease in Children With Recent Onset Type 1 Diabetes Recruiting NCT03037190
17 Puerarin Versus Atorvastatin in Treating Metabolism Syndrome in Patients With Chronic Rheumatic Diseases Active, not recruiting NCT02219191

Search NIH Clinical Center for Insulin Autoimmune Syndrome

Genetic Tests for Insulin Autoimmune Syndrome

Anatomical Context for Insulin Autoimmune Syndrome

MalaCards organs/tissues related to Insulin Autoimmune Syndrome:

39
T Cells, Skin

Publications for Insulin Autoimmune Syndrome

Articles related to Insulin Autoimmune Syndrome:

(show top 50) (show all 91)
id Title Authors Year
1
Insulin Autoimmune Syndrome: a rare cause of postprandial hypoglycemia. ( 27855237 )
2016
2
Novel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring. ( 26982011 )
2016
3
Insulin autoimmune syndrome in a child with type 1 diabetes: Clinical, immunological, and biochemical correlations. ( 27773181 )
2016
4
Gliclazide - Induced Insulin Autoimmune Syndrome: A Rare Case Report and Review on Literature. ( 28017142 )
2016
5
Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange. ( 27588366 )
2016
6
The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis. ( 27071154 )
2016
7
Insulin autoimmune syndrome during administration of Clopidogrel. ( 26847582 )
2016
8
Insulin Autoimmune Syndrome Accompanied by Multiple Myeloma. ( 27522998 )
2016
9
Human serum albumin: Possible cause of insulin autoimmune syndrome. ( 27804283 )
2016
10
Methimazole-induced insulin autoimmune syndrome. ( 27540463 )
2016
11
Unusual Manifestations of Essential Monoclonal Gammopathy. II. Simulation of the Insulin Autoimmune Syndrome. ( 26241232 )
2015
12
Insulin Autoimmune Syndrome: 73 Cases of Clinical Analysis. ( 26315093 )
2015
13
Rare association of insulin autoimmune syndrome with ankylosing spondylitis. ( 26527431 )
2015
14
Analytical and clinical challenges in a patient with concurrent type 1 diabetes, subcutaneous insulin resistance and insulin autoimmune syndrome. ( 24711924 )
2014
15
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. ( 25289063 )
2014
16
Use of the continuous glucose monitoring system to treat insulin autoimmune syndrome: quantification of glucose excursions and evaluation of treatment efficacy. ( 25077287 )
2014
17
An uncommon cause of hypoglycemia: insulin autoimmune syndrome. ( 25060673 )
2014
18
Recurrent hypoglycemia from insulin autoimmune syndrome. ( 23979685 )
2014
19
Two cases of methimazole-induced insulin autoimmune syndrome in graves' disease. ( 24396652 )
2013
20
Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. ( 24190150 )
2013
21
Insulin autoimmune syndrome in a health supplement user: the effectiveness of cornstarch therapy for treating hypoglycemia. ( 23370747 )
2013
22
A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. ( 23843578 )
2013
23
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking I+-lipoic acid. ( 24111525 )
2013
24
Recurrent Insulin Autoimmune Syndrome Caused by I+-Lipoic Acid in Type 2 Diabetes. ( 24396698 )
2013
25
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. ( 23817229 )
2013
26
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. ( 24386337 )
2013
27
Insulin autoimmune syndrome induced by methimazole in a Korean girl with Graves' disease. ( 24904848 )
2013
28
Insulin glulisine may cause a disease resembling insulin autoimmune syndrome: case report. ( 24265369 )
2013
29
Severe hypoglycemia secondary toA methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male. ( 22759245 )
2012
30
High prevalence of both anti-insulin and anti-insulin receptor antibodies in Korean patients with insulin autoimmune syndrome. ( 23000370 )
2012
31
Fulminant Type 1 diabetes in a pregnant woman as an initial manifestation of the insulin autoimmune syndrome. ( 22356444 )
2012
32
Late postprandial hypoglycemia due to bioactive insulin dissociation from autoantibody leading to unconsciousness in a patient with insulin autoimmune syndrome. ( 21325768 )
2011
33
Insulin autoimmune syndrome: a case associated with HLA-DRB1 polymorphism. ( 21897108 )
2011
34
Insulin autoimmune syndrome induced by I+-lipoic acid in a Caucasian woman: case report. ( 21868770 )
2011
35
Drug-induced insulin autoimmune syndrome. ( 19070385 )
2009
36
Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis. ( 21437150 )
2008
37
Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. ( 16963149 )
2007
38
Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement. ( 18042740 )
2007
39
Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B. ( 17956452 )
2007
40
Alpha-lipoic acid and insulin autoimmune syndrome. ( 17586737 )
2007
41
Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. ( 17329919 )
2007
42
The novel agent, alpha lipoic acid, can cause the development of insulin autoimmune syndrome. ( 17827827 )
2007
43
A case of insulin autoimmune syndrome with HLA DRB1*0404: impact on the hypothesis for the molecular pathogenesis involving DRB1 molecules. ( 16409576 )
2006
44
Insulin autoimmune syndrome (Hirata disease) as differential diagnosis in patients with hyperinsulinemic hypoglycemia. ( 16670629 )
2006
45
Severe hypoglycemic coma due to insulin autoimmune syndrome. ( 15759820 )
2005
46
Insulin Autoimmune Syndrome (Hirata's disease): severe hypoglycemic episodes in Graves' hyperthyroidism patient treated with methimazole. ( 16377854 )
2005
47
Insulin autoimmune syndrome due to IgG kappa paraprotein. ( 14757564 )
2004
48
[Hypoglycemia and transient diabetes mellitus in an insulin autoimmune syndrome]. ( 15143456 )
2004
49
Insulin autoimmune syndrome: case report. ( 15543375 )
2004
50
Insulin autoimmune syndrome in a patient with viral hepatitis C. ( 12201836 )
2002

Variations for Insulin Autoimmune Syndrome

Expression for Insulin Autoimmune Syndrome

Search GEO for disease gene expression data for Insulin Autoimmune Syndrome.

Pathways for Insulin Autoimmune Syndrome

Pathways related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 INS INSR
2
Show member pathways
12.33 INS INSR
3
Show member pathways
12.27 INS INSR
4
Show member pathways
12.27 INS INSR
5 12.16 INS INSR
6
Show member pathways
12.1 INS INSR
7
Show member pathways
12.08 INS INSR
8 12.07 INS INSR
9
Show member pathways
12.05 INS INSR
10
Show member pathways
12.01 INS INSR
11
Show member pathways
11.97 INS INSR
12
Show member pathways
11.91 INS INSR
13
Show member pathways
11.8 INS INSR
14
Show member pathways
11.74 INS INSR
15
Show member pathways
11.72 INS INSR
16
Show member pathways
11.68 INS INSR
17
Show member pathways
11.62 INS INSR
18
Show member pathways
11.55 INS INSR
19 11.49 INS INSR
20
Show member pathways
11.44 INS INSR
21 11.25 INS INSR
22 11.14 INS INSR
23 11.07 INS INSR
24 11.02 INS INSR
25 10.89 INS INSR
26 10.89 INS INSR
27
Show member pathways
10.78 INS INSR
28 10.52 INS INSR
29 10.09 INS INSR

GO Terms for Insulin Autoimmune Syndrome

Biological processes related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.55 INS INSR
2 carbohydrate metabolic process GO:0005975 9.54 INS INSR
3 positive regulation of cell migration GO:0030335 9.52 INS INSR
4 glucose homeostasis GO:0042593 9.51 INS INSR
5 positive regulation of MAPK cascade GO:0043410 9.49 INS INSR
6 positive regulation of protein kinase B signaling GO:0051897 9.48 INS INSR
7 insulin receptor signaling pathway GO:0008286 9.46 INS INSR
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 INS INSR
9 positive regulation of DNA replication GO:0045740 9.4 INS INSR
10 positive regulation of glucose import GO:0046326 9.37 INS INSR
11 activation of protein kinase B activity GO:0032148 9.32 INS INSR
12 positive regulation of mitotic nuclear division GO:0045840 9.26 INS INSR
13 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS INSR
14 positive regulation of glycolytic process GO:0045821 8.96 INS INSR
15 positive regulation of respiratory burst GO:0060267 8.62 INS INSR

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.62 INS INSR

Sources for Insulin Autoimmune Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....