MCID: INS006
MIFTS: 36

Insulin Autoimmune Syndrome malady

Rare diseases category
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Summaries for Insulin Autoimmune Syndrome

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33MalaCards
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MalaCards: Insulin Autoimmune Syndrome, also known as hirata disease, is related to hypoglycemia and hyperinsulinemic hypoglycemia. An important gene associated with Insulin Autoimmune Syndrome is INS (insulin), and among its related pathways are AMPK Enzyme Complex Pathway and FoxO signaling pathway. The compounds poly(glu(80)tyr(20)) and chromium picolinate have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are behavior/neurological and liver/biliary system.

Aliases & Classifications for Insulin Autoimmune Syndrome

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

insulin autoimmune syndrome 43 62
hirata disease 43


Related Diseases for Insulin Autoimmune Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Insulin Autoimmune Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.9INSR, INS
2hyperinsulinemic hypoglycemia30.2INS
3hyperthyroidism30.2INS, INSR
4insulinoma30.1INS, INSR
5diabetes mellitus30.1INSR, INS
6graves' disease10.5
7hypoglycemic coma10.2
8fetal macrosomia10.1INS
9hepatitis c10.1
10arthritis10.1
11glomerulonephritis10.1
12hepatitis10.1
13rheumatoid arthritis10.1
14viral hepatitis10.1
15brittle diabetes10.1
16donohue syndrome10.0INSR, INS
17rabson-mendenhall syndrome10.0INSR, INS
18congenital generalized lipodystrophy type 210.0INS, INSR
19acanthosis nigricans10.0INSR, INS
20gestational diabetes10.0INSR, INS
21hyperandrogenism10.0INSR, INS
22lipodystrophy10.0INS, INSR
23glucose intolerance10.0INS, INSR
24diabetic retinopathy10.0INSR, INS
25hypertriglyceridemia10.0INSR, INS
26polycystic ovary syndrome10.0INSR, INS
27fatty liver disease10.0INSR, INS
28hypercholesterolemia10.0INSR, INS
29hyperinsulinism10.0INS, INSR
30essential hypertension10.0INS, INSR
31type 1 diabetes mellitus10.0INSR, INS
32cholera10.0INSR, INS
33metabolic syndrome x10.0INS, INSR
34hyperglycemia10.0INS, INSR
35coronary artery disease10.0INS, INSR
36stroke, ischemic10.0INS, F5
37galactosemia10.0F5, INS
38type 2 diabetes mellitus10.0INSR, INS
39factor v leiden thrombophilia10.0INSR, F5
40pre-eclampsia10.0F5, INSR
41vascular disease10.0F5, INS
42insulin resistance10.0INSR, INS
43sepsis10.0F5, INSR
44primary hyperoxaluria10.0INSR, INS
45hypertension9.9F5, INSR, INS

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to insulin autoimmune syndrome

Symptoms for Insulin Autoimmune Syndrome

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Drugs & Therapeutics for Insulin Autoimmune Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Insulin Autoimmune Syndrome

Search NIH Clinical Center for Insulin Autoimmune Syndrome

Genetic Tests for Insulin Autoimmune Syndrome

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Anatomical Context for Insulin Autoimmune Syndrome

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33MalaCards
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MalaCards organs/tissues related to Insulin Autoimmune Syndrome:

33
Skin, T cells

Animal Models for Insulin Autoimmune Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Insulin Autoimmune Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5F5, INSR, INS
2MP:00053708.4F5, INSR, INS
3MP:00053858.2F5, INSR, INS

Publications for Insulin Autoimmune Syndrome

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52PubMed
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Articles related to Insulin Autoimmune Syndrome:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Recurrent hypoglycemia from insulin autoimmune syndrome. (23979685)
2014
2
Recurrent Insulin Autoimmune Syndrome Caused by I+-Lipoic Acid in Type 2 Diabetes. (24396698)
2013
3
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking I+-lipoic acid. (24111525)
2013
4
Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. (24190150)
2013
5
Two cases of methimazole-induced insulin autoimmune syndrome in graves' disease. (24396652)
2013
6
Insulin autoimmune syndrome in a health supplement user: the effectiveness of cornstarch therapy for treating hypoglycemia. (23370747)
2013
7
Insulin glulisine may cause a disease resembling insulin autoimmune syndrome: case report. (24265369)
2013
8
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. (24386337)
2013
9
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. (23817229)
2013
10
A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. (23843578)
2013
11
Severe hypoglycemia secondary toA methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male. (22759245)
2012
12
High prevalence of both anti-insulin and anti-insulin receptor antibodies in Korean patients with insulin autoimmune syndrome. (23000370)
2012
13
Insulin autoimmune syndrome induced by I+-lipoic acid in a Caucasian woman: case report. (21868770)
2011
14
Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis. (21437150)
2008
15
The novel agent, alpha lipoic acid, can cause the development of insulin autoimmune syndrome. (17827827)
2007
16
Alpha-lipoic acid and insulin autoimmune syndrome. (17586737)
2007
17
Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. (16963149)
2007
18
Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (17329919)
2007
19
Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement. (18042740)
2007
20
Insulin autoimmune syndrome (Hirata disease) as differential diagnosis in patients with hyperinsulinemic hypoglycemia. (16670629)
2006
21
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
22
Insulin Autoimmune Syndrome (Hirata's disease): severe hypoglycemic episodes in Graves' hyperthyroidism patient treated with methimazole. (16377854)
2005
23
Insulin autoimmune syndrome: case report. (15543375)
2004
24
Hypoglycemia and transient diabetes mellitus in an insulin autoimmune syndrome]. (15143456)
2004
25
Insulin autoimmune syndrome in a patient with viral hepatitis C. (12201836)
2002
26
Hypoglycaemia due to insulin autoimmune syndrome: report of two cases with characterisation of HLA alleles and insulin autoantibodies. (11517012)
2001
27
Severe hypoglycemia due to insulin autoimmune syndrome with insulin autoantibodies crossreactive to proinsulin. (11453038)
2001
28
Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401. (11182636)
2000
29
Insulin autoimmune syndrome: a rare cause of hypoglycaemia not to be overlooked. (10592867)
1999
30
Insulin autoimmune syndrome after therapy with imipenem. (10097941)
1999
31
Insulin autoimmune syndrome (IAS, Hirata disease). (10445096)
1999
32
Recurrent hypoglycaemia caused by the insulin autoimmune syndrome: the first Dutch case. (8710037)
1996
33
A novel concept of type VII hypersensitivity introduced by insulin autoimmune syndrome (Hirata's disease) (7578882)
1995
34
Insulin autoimmune syndrome after the third therapy with methimazole. (7647412)
1995
35
Insulin autoimmune syndrome as a cause of spontaneous hypoglycemia in alcoholic cirrhosis. (7557152)
1995
36
Longitudinal changes of serum insulin concentration and insulin antibody features in persistent insulin autoimmune syndrome (Hirata's disease). (7578855)
1994
37
Insulin autoimmune syndrome in a patient with methimazole and carbimazole-treated Graves' disease: a case report. (7834559)
1994
38
Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors. (8228261)
1993
39
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)
1992
40
Insulin autoimmune syndrome and HLA-DR4. (1351232)
1992
41
Delayed disappearance of human compared to porcine insulin in a patient with the insulin autoimmune syndrome. (2407482)
1990
42
Human monoclonal IgG1 insulin autoantibody from insulin autoimmune syndrome directed at determinant at asparagine site on insulin B-chain. (2469609)
1989
43
Insulin autoimmune syndrome associated with benign monoclonal gammopathy. Evidence for monoclonal insulin autoantibodies. (2702896)
1989
44
Reverse phase high performance liquid chromatographic analysis of circulating insulin in the insulin autoimmune syndrome. (3275683)
1988
45
Rebound of antibody titer to insulin following rechallenge with thiamazole in a patient with insulin autoimmune syndrome. (3245045)
1988
46
Erythrocyte insulin receptor in insulin autoimmune syndrome: effects of corticosteroid therapy. (3554614)
1987
47
Clinical and biochemical aspects of the insulin autoimmune syndrome (IAIS). (3537496)
1986
48
Methimazole and insulin autoimmune syndrome. (6139656)
1983
49
Effects of antithyroid drugs on lymphocyte proliferative responses to lectins: relationship between insulin autoimmune syndrome and methimazole. (6689431)
1983
50
Mechanism of hypoglycemia observed in a patient with insulin autoimmune syndrome. (856650)
1977

Variations for Insulin Autoimmune Syndrome

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Expression for genes affiliated with Insulin Autoimmune Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Insulin Autoimmune Syndrome

Search GEO for disease gene expression data for Insulin Autoimmune Syndrome.

Pathways for genes affiliated with Insulin Autoimmune Syndrome

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 54R&D Systems, 61Tocris Bioscience, 51PharmGKB, 12EMD Millipore, 5Cell Signaling Technology
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Pathways related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3INSR, INS
2
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.3INSR, INS
3
Show member pathways
9.3INSR, INS
49.3INSR, INS
5
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.3INSR, INS
6
Show member pathways
9.3INSR, INS
7
Show member pathways
9.3INSR, INS
89.3INSR, INS
9
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.3INSR, INS
10
Show member pathways
9.3INSR, INS
11
Show member pathways
thioredoxin pathway38
9.3INSR, INS
129.3INSR, INS
13
Show member pathways
Insulin Pathway38
9.3INSR, INS
14
Show member pathways
9.3INSR, INS
159.3INSR, INS
169.3INSR, INS
179.3INS, INSR
18
Show member pathways
9.3INS, INSR
199.3INS, INSR
209.3INS, INSR
21
Show member pathways
9.3INS, INSR
229.3INS, INSR
239.3INS, INSR
249.3INS, INSR

Compounds for genes affiliated with Insulin Autoimmune Syndrome

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1poly(glu(80)tyr(20))459.8INSR, INS
2chromium picolinate459.8INSR, INS
3mecasermin45 1110.8INSR, INS
4vanadyl sulfate459.8INSR, INS
5preproinsulin459.8INS, INSR
6moxonidine459.8INSR, INS
7gliclazide45 51 1111.8INSR, INS
8glimepiride45 51 1111.8INS, INSR
9clomiphene citrate459.7INSR, INS
10aicar45 24 1111.7INSR, INS
11alpha lipoic acid459.7INS, INSR
12streptozotocin459.7INSR, INS
13fenofibrate45 51 1111.7INSR, INS
14glibenclamide45 29 51 6112.7INSR, INS
152-deoxyglucose45 1110.7INSR, INS
16octreotide45 61 29 1112.7INS, INSR
17c-peptide459.7INSR, INS
18pioglitazone29 45 51 1112.7INSR, INS
19palmitate459.6INSR, INS
20rosiglitazone29 45 51 24 1113.6INS, INSR
21troglitazone45 29 61 1112.6INSR, INS
22ibmx45 61 2911.6INSR, INS
23carbohydrates459.5INS, INSR
24thyroxine45 2410.5INSR, INS
25tunicamycin45 6110.5F5, INSR
26desogestrel45 1110.5INS, F5
27pge1459.5F5, INSR
28cyproteroneacetate459.4F5, INS
29progestin459.4INSR, F5
30protamine459.4F5, INS
31polyethylene glycol459.4F5, INSR
32glycerol45 24 1111.4INSR, INS
33citrate459.4F5, INSR
34uric acid45 2410.3F5, INS
35cyclophosphamide45 51 1111.3F5, INSR
36prostacyclin459.2INSR, F5
37polysaccharide459.1F5, INSR
38metformin45 51 1111.0F5, INSR, INS
39hydrocortisone45 3 61 1112.0INS, INSR, F5
40epinephrine45 24 1110.9F5, INSR, INS
41glycogen45 249.9F5, INSR, INS
42tacrolimus45 51 1110.9INS, F5
43creatinine458.9INS, INSR, F5
44testosterone45 61 24 1111.9F5, INSR, INS
45arginine458.9INS, INSR, F5
46glutamate458.9INS, INSR, F5
47alanine458.9F5, INSR, INS
48estrogen458.8INS, INSR, F5
49phosphatidylcholine458.8F5, INSR
50serine458.5F5, INSR, INS

GO Terms for genes affiliated with Insulin Autoimmune Syndrome

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16Gene Ontology
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Biological processes related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of respiratory burstGO:0602679.6INSR, INS
2positive regulation of glycolytic processGO:0458219.6INSR, INS
3positive regulation of glycogen biosynthetic processGO:0457259.6INSR, INS
4activation of protein kinase B activityGO:0321489.6INS, INSR
5positive regulation of glucose importGO:0463269.6INSR, INS
6positive regulation of mitosisGO:0458409.5INSR, INS
7positive regulation of nitric oxide biosynthetic processGO:0454299.5INSR, INS
8positive regulation of DNA replicationGO:0457409.5INS, INSR
9positive regulation of MAPK cascadeGO:0434109.4INSR, INS
10positive regulation of protein kinase B signalingGO:0518979.4INSR, INS
11glucose homeostasisGO:0425939.3INS, INSR
12G-protein coupled receptor signaling pathwayGO:0071869.3INSR, INS
13positive regulation of cell migrationGO:0303359.2INSR, INS
14insulin receptor signaling pathwayGO:0082869.0INSR, INS

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3INSR, INS

Products for genes affiliated with Insulin Autoimmune Syndrome

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  • Antibodies
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Sources for Insulin Autoimmune Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet