MCID: INS006
MIFTS: 24

Insulin Autoimmune Syndrome malady

Summaries for Insulin Autoimmune Syndrome

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32MalaCards
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MalaCards: Insulin Autoimmune Syndrome, also known as hirata disease, is related to hypoglycemia and hyperinsulinemic hypoglycemia. An important gene associated with Insulin Autoimmune Syndrome is INS (insulin), and among its related pathways are HIF-1 signaling pathway and Selenium Pathway. The compounds palmitate and desogestrel have been mentioned in the context of this disorder. Related mouse phenotype liver/biliary system.

Aliases & Classifications for Insulin Autoimmune Syndrome

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

insulin autoimmune syndrome 42 60
hirata disease 42


Related Diseases for Insulin Autoimmune Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Insulin Autoimmune Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.8INSR, INS
2hyperinsulinemic hypoglycemia30.0INS
3rheumatoid arthritis30.0INSR
4hyperthyroidism30.0INSR, INS
5diabetes mellitus30.0INS, INSR
6insulinoma30.0INSR, INS
7graves' disease10.5
8hypoglycemic coma10.2
9hepatitis c10.0
10autoimmune hepatitis10.0
11hepatitis a10.0
12arthritis10.0
13glomerulonephritis10.0
14hepatitis10.0
15viral hepatitis10.0
16ovarian hyperstimulation syndrome10.0F5
17pulmonary embolism10.0F5
18myocardial infarction10.0F5
19antiphospholipid syndrome10.0F5
20hyperhomocysteinemia10.0F5
21hypogonadism10.0INS
22fetal macrosomia10.0INS
23coronary heart disease10.0INS
24diabetic ketoacidosis10.0INS
25gastroparesis10.0INS
26peripheral vascular disease10.0INS
27infertility10.0INS
28amenorrhea10.0INS
29lupus erythematosus10.0F5
30growth hormone deficiency10.0INS
31acromegaly10.0INS
32atherosclerosis10.0INS
33maturity-onset diabetes of the young10.0INS
34stroke, ischemic10.0F5
35myotonic dystrophy10.0INSR
36dementia10.0INSR
37ischemia10.0INSR
38werner syndrome10.0INSR
39morbid obesity10.0INS
40uremia10.0INSR
41thromboembolism10.0F5
42galactosemia10.0INS, F5
43rabson-mendenhall syndrome10.0INS, INSR
44donohue syndrome10.0INSR, INS
45congenital generalized lipodystrophy type 210.0INSR, INS
46acanthosis nigricans10.0INSR, INS
47essential hypertension10.0INS, INSR
48vascular disease10.0INS, F5
49polycystic ovary syndrome10.0INSR, INS
50gestational diabetes10.0INSR, INS

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to insulin autoimmune syndrome

Clinical Features for Insulin Autoimmune Syndrome

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Drugs & Therapeutics for Insulin Autoimmune Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Insulin Autoimmune Syndrome

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Anatomical Context for Insulin Autoimmune Syndrome

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Animal Models for Insulin Autoimmune Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Insulin Autoimmune Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5INSR, INS, F5

Publications for Insulin Autoimmune Syndrome

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Genetic Variations for Insulin Autoimmune Syndrome

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Expression for genes affiliated with Insulin Autoimmune Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Insulin Autoimmune Syndrome

Search GEO for disease gene expression data for Insulin Autoimmune Syndrome.

Pathways for genes affiliated with Insulin Autoimmune Syndrome

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 4Cell Signaling Technology, 52R&D Systems, 12EMD Millipore, 49PharmGKB
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Compounds for genes affiliated with Insulin Autoimmune Syndrome

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1palmitate4410.1INS
2desogestrel44 1110.8F5, INS
3cyproteroneacetate449.7INS, F5
4protamine449.7INS, F5
5uric acid44 2410.6F5, INS
6poly(glu(80)tyr(20))449.5INSR, INS
7chromium picolinate449.5INS, INSR
8mecasermin44 1110.5INSR, INS
9vanadyl sulfate449.5INSR, INS
10preproinsulin449.5INS, INSR
11tunicamycin44 5910.5F5, INSR
12moxonidine449.5INSR, INS
13glimepiride44 49 1111.4INS, INSR
14gliclazide44 49 1111.4INS, INSR
15pge1449.4INSR, F5
16clomiphene citrate449.4INS, INSR
17aicar44 11 2411.4INSR, INS
18progestin449.4F5, INSR
19alpha lipoic acid449.4INS, INSR
20polyethylene glycol449.4F5, INSR
21streptozotocin449.4INSR, INS
22fenofibrate44 49 1111.4INSR, INS
23glibenclamide44 28 49 5912.4INS, INSR
242-deoxyglucose44 1110.4INSR, INS
25octreotide44 59 28 1112.4INSR, INS
26c-peptide449.4INS, INSR
27pioglitazone44 49 28 1112.4INSR, INS
28citrate449.3INSR, F5
29rosiglitazone44 49 28 11 2413.3INS, INSR
30troglitazone44 28 59 1112.3INSR, INS
31ibmx44 28 5911.2INSR, INS
32tacrolimus44 49 1111.2INS, F5
33cyclophosphamide44 49 1111.2F5, INSR
34carbohydrates449.2INS, INSR
35thyroxine44 2410.1INS, INSR
36prostacyclin449.1INSR, F5
37phosphatidylcholine449.1F5, INSR
38metformin44 49 1111.0F5, INSR, INS
39hydrocortisone44 2 59 1111.9INS, F5, INSR
40epinephrine44 11 2410.9INSR, F5, INS
41glycogen44 249.9INSR, F5, INS
42creatinine448.9INSR, INS, F5
43testosterone44 59 11 2411.9INS, INSR, F5
44arginine448.9F5, INS, INSR
45alanine448.8INS, F5, INSR
46estrogen448.8F5, INS, INSR
47glycerol44 11 2410.7INSR, INS

GO Terms for genes affiliated with Insulin Autoimmune Syndrome

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16Gene Ontology
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Biological processes related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of respiratory burstGO:0602679.3INS, INSR
2positive regulation of glycolysisGO:0458219.3INS, INSR
3positive regulation of glycogen biosynthetic processGO:0457259.3INS, INSR
4activation of protein kinase B activityGO:0321489.3INS, INSR
5positive regulation of glucose importGO:0463269.2INS, INSR
6positive regulation of mitosisGO:0458409.2INS, INSR
7positive regulation of nitric oxide biosynthetic processGO:0454299.2INSR, INS
8positive regulation of DNA replicationGO:0457409.1INS, INSR
9positive regulation of MAPK cascadeGO:0434109.1INS, INSR
10positive regulation of protein kinase B signaling cascadeGO:0518979.0INS, INSR
11insulin receptor signaling pathwayGO:0082869.0INS, INSR
12glucose homeostasisGO:0425938.9INS, INSR
13positive regulation of cell migrationGO:0303358.7INSR, INS

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.0INSR, INS

Products for genes affiliated with Insulin Autoimmune Syndrome

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  • Antibodies
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Sources for Insulin Autoimmune Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet