MCID: INS006
MIFTS: 39

Insulin Autoimmune Syndrome

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Insulin Autoimmune Syndrome

MalaCards integrated aliases for Insulin Autoimmune Syndrome:

Name: Insulin Autoimmune Syndrome 49 55 69
Hirata Disease 49 55
Insulin Autoimmune Hypoglycemia 49

Characteristics:

Orphanet epidemiological data:

55
insulin autoimmune syndrome
Inheritance: Not applicable; Age of onset: Adult,Elderly;

Classifications:

Orphanet: 55  
Rare endocrine diseases


External Ids:

Orphanet 55 ORPHA411593
UMLS via Orphanet 70 C0854359
ICD10 via Orphanet 33 E16.1
UMLS 69 C0854359

Summaries for Insulin Autoimmune Syndrome

NIH Rare Diseases : 49 Insulin autoimmune syndrome is a rare condition that causes low blood sugar (hypoglycemia). This occurs because the body begins to make a specific kind of protein called antibodies to attack insulin. Insulin is a naturally occurring hormone that is responsible for keeping blood sugar at a normal level. When blood sugar levels get too high, insulin helps to store the sugar for future use. People affected by insulin autoimmune syndrome have antibodies that attack insulin, causing it to work too hard and the level of blood sugar to become too low. Insulin autoimmune syndrome most often begins during adulthood. Last updated: 11/13/2016

MalaCards based summary : Insulin Autoimmune Syndrome, also known as hirata disease, is related to hypoglycemia and hyperinsulinemic hypoglycemia, and has symptoms including hyperinsulinemic hypoglycemia, insulin-resistant diabetes mellitus and systemic lupus erythematosus. An important gene associated with Insulin Autoimmune Syndrome is INS (Insulin), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Affiliated tissues include t cells and skin.

Related Diseases for Insulin Autoimmune Syndrome

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to Insulin Autoimmune Syndrome

Symptoms & Phenotypes for Insulin Autoimmune Syndrome

Human phenotypes related to Insulin Autoimmune Syndrome:

55 31 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperinsulinemic hypoglycemia 55 31 obligate (100%) Obligate (100%) HP:0000825
2 insulin-resistant diabetes mellitus 55 31 hallmark (90%) Very frequent (99-80%) HP:0000831
3 systemic lupus erythematosus 55 31 hallmark (90%) Very frequent (99-80%) HP:0002725
4 increased antibody level in blood 55 31 hallmark (90%) Very frequent (99-80%) HP:0010702
5 autoimmune antibody positivity 55 31 hallmark (90%) Very frequent (99-80%) HP:0030057
6 acanthosis nigricans 55 31 frequent (33%) Frequent (79-30%) HP:0000956
7 weight loss 55 31 frequent (33%) Frequent (79-30%) HP:0001824
8 nonketotic hypoglycemia 55 31 frequent (33%) Frequent (79-30%) HP:0001958
9 fasting hypoglycemia 55 31 frequent (33%) Frequent (79-30%) HP:0003162
10 arthralgia/arthritis 55 31 frequent (33%) Frequent (79-30%) HP:0005059
11 reactive hypoglycemia 55 31 frequent (33%) Frequent (79-30%) HP:0012051
12 insulin resistance 55 Very frequent (99-80%)
13 autoimmunity 55 Frequent (79-30%)

Drugs & Therapeutics for Insulin Autoimmune Syndrome

Search Clinical Trials , NIH Clinical Center for Insulin Autoimmune Syndrome

Genetic Tests for Insulin Autoimmune Syndrome

Anatomical Context for Insulin Autoimmune Syndrome

MalaCards organs/tissues related to Insulin Autoimmune Syndrome:

38
T Cells, Skin

Publications for Insulin Autoimmune Syndrome

Articles related to Insulin Autoimmune Syndrome:

(show top 50) (show all 100)
# Title Authors Year
1
Insulin autoimmune syndrome in a pregnant female: A rare case report: Erratum. ( 29369220 )
2018
2
Therapeutic plasma exchange normalizes insulin-mediated response in a child with type 1 diabetes and insulin autoimmune syndrome. ( 28370959 )
2017
3
Rare Cause of Recurrent Hypoglycemia: Insulin Autoimmune Syndrome. ( 29318060 )
2017
4
Insulin autoimmune syndrome (Hirata's disease) in an Italian patient: a case report and review of the literature. ( 28917079 )
2017
5
Clopidogrel-Induced Insulin Autoimmune Syndrome: A Newly Recognized Cause of Hypoglycemia in a Patient Without Diabetes. ( 29264578 )
2017
6
Resolution of Hypoglycemia and Cardiovascular Dysfunction After Rituximab Treatment of Insulin Autoimmune Syndrome. ( 28461453 )
2017
7
Immunoadsorption Followed by Rituximab as a Definitive Treatment for Insulin Autoimmune Syndrome (Hirata Syndrome): A Case Report. ( 29282202 )
2017
8
Insulin autoimmune syndrome in a pregnant female: A rare case report. ( 29390469 )
2017
9
Insulin autoimmune syndrome during administration of Clopidogrel. ( 26847582 )
2016
10
Other Antibodies Resulting in Diabetes Mellitus: Type B Insulin Resistance and Insulin Autoimmune Syndrome ( 26789344 )
2016
11
The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis. ( 27071154 )
2016
12
Insulin Autoimmune Syndrome: a rare cause of postprandial hypoglycemia. ( 27855237 )
2016
13
Novel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring. ( 26982011 )
2016
14
Methimazole-induced insulin autoimmune syndrome. ( 27540463 )
2016
15
Insulin autoimmune syndrome in a child with type 1 diabetes: Clinical, immunological, and biochemical correlations. ( 27773181 )
2016
16
Gliclazide - Induced Insulin Autoimmune Syndrome: A Rare Case Report and Review on Literature. ( 28017142 )
2016
17
Insulin Autoimmune Syndrome Accompanied by Multiple Myeloma. ( 27522998 )
2016
18
Human serum albumin: Possible cause of insulin autoimmune syndrome. ( 27804283 )
2016
19
Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange. ( 27588366 )
2016
20
Rare association of insulin autoimmune syndrome with ankylosing spondylitis. ( 26527431 )
2015
21
Insulin Autoimmune Syndrome: 73 Cases of Clinical Analysis. ( 26315093 )
2015
22
Unusual Manifestations of Essential Monoclonal Gammopathy. II. Simulation of the Insulin Autoimmune Syndrome. ( 26241232 )
2015
23
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. ( 25289063 )
2014
24
Use of the continuous glucose monitoring system to treat insulin autoimmune syndrome: quantification of glucose excursions and evaluation of treatment efficacy. ( 25077287 )
2014
25
Recurrent hypoglycemia from insulin autoimmune syndrome. ( 23979685 )
2014
26
An uncommon cause of hypoglycemia: insulin autoimmune syndrome. ( 25060673 )
2014
27
Analytical and clinical challenges in a patient with concurrent type 1 diabetes, subcutaneous insulin resistance and insulin autoimmune syndrome. ( 24711924 )
2014
28
A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. ( 23843578 )
2013
29
Two cases of methimazole-induced insulin autoimmune syndrome in graves' disease. ( 24396652 )
2013
30
Insulin glulisine may cause a disease resembling insulin autoimmune syndrome: case report. ( 24265369 )
2013
31
Recurrent Insulin Autoimmune Syndrome Caused by I+-Lipoic Acid in Type 2 Diabetes. ( 24396698 )
2013
32
Insulin autoimmune syndrome in a health supplement user: the effectiveness of cornstarch therapy for treating hypoglycemia. ( 23370747 )
2013
33
Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. ( 24190150 )
2013
34
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. ( 23817229 )
2013
35
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking I+-lipoic acid. ( 24111525 )
2013
36
Insulin autoimmune syndrome induced by methimazole in a Korean girl with Graves' disease. ( 24904848 )
2013
37
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. ( 24386337 )
2013
38
High prevalence of both anti-insulin and anti-insulin receptor antibodies in Korean patients with insulin autoimmune syndrome. ( 23000370 )
2012
39
Severe hypoglycemia secondary toA methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male. ( 22759245 )
2012
40
Fulminant Type 1 diabetes in a pregnant woman as an initial manifestation of the insulin autoimmune syndrome. ( 22356444 )
2012
41
Insulin autoimmune syndrome induced by I+-lipoic acid in a Caucasian woman: case report. ( 21868770 )
2011
42
Late postprandial hypoglycemia due to bioactive insulin dissociation from autoantibody leading to unconsciousness in a patient with insulin autoimmune syndrome. ( 21325768 )
2011
43
Insulin autoimmune syndrome: a case associated with HLA-DRB1 polymorphism. ( 21897108 )
2011
44
Drug-induced insulin autoimmune syndrome. ( 19070385 )
2009
45
Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis. ( 21437150 )
2008
46
Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement. ( 18042740 )
2007
47
Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B. ( 17956452 )
2007
48
Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. ( 17329919 )
2007
49
Alpha-lipoic acid and insulin autoimmune syndrome. ( 17586737 )
2007
50
Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. ( 16963149 )
2007

Variations for Insulin Autoimmune Syndrome

Expression for Insulin Autoimmune Syndrome

Search GEO for disease gene expression data for Insulin Autoimmune Syndrome.

Pathways for Insulin Autoimmune Syndrome

Pathways related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 INS INSR
2
Show member pathways
12.32 INS INSR
3 12.3 INS INSR
4
Show member pathways
12.27 INS INSR
5
Show member pathways
12.27 INS INSR
6
Show member pathways
12.26 INS INSR
7 12.1 INS INSR
8
Show member pathways
12.09 INS INSR
9
Show member pathways
12.07 INS INSR
10
Show member pathways
12.04 INS INSR
11
Show member pathways
12.01 INS INSR
12
Show member pathways
11.97 INS INSR
13
Show member pathways
11.91 INS INSR
14
Show member pathways
11.8 INS INSR
15
Show member pathways
11.74 INS INSR
16
Show member pathways
11.72 INS INSR
17
Show member pathways
11.66 INS INSR
18
Show member pathways
11.63 INS INSR
19
Show member pathways
11.6 INS INSR
20
Show member pathways
11.53 INS INSR
21 11.48 INS INSR
22
Show member pathways
11.44 INS INSR
23 11.25 INS INSR
24 11.14 INS INSR
25 11.07 INS INSR
26 11.02 INS INSR
27 10.89 INS INSR
28
Show member pathways
10.78 INS INSR
29 10.52 INS INSR
30 10.09 INS INSR

GO Terms for Insulin Autoimmune Syndrome

Biological processes related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.56 INS INSR
2 carbohydrate metabolic process GO:0005975 9.55 INS INSR
3 positive regulation of cell migration GO:0030335 9.54 INS INSR
4 positive regulation of protein kinase B signaling GO:0051897 9.52 INS INSR
5 glucose homeostasis GO:0042593 9.51 INS INSR
6 positive regulation of MAPK cascade GO:0043410 9.49 INS INSR
7 insulin receptor signaling pathway GO:0008286 9.48 INS INSR
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.46 INS INSR
9 positive regulation of DNA replication GO:0045740 9.43 INS INSR
10 activation of protein kinase B activity GO:0032148 9.4 INS INSR
11 positive regulation of glucose import GO:0046326 9.37 INS INSR
12 positive regulation of mitotic nuclear division GO:0045840 9.32 INS INSR
13 positive regulation of glycolytic process GO:0045821 9.26 INS INSR
14 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS INSR
15 positive regulation of respiratory burst GO:0060267 8.96 INS INSR
16 neuron projection maintenance GO:1990535 8.62 INS INSR

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.62 INS INSR

Sources for Insulin Autoimmune Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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