MCID: INS006
MIFTS: 39

Insulin Autoimmune Syndrome malady

Rare diseases, Neuronal diseases, Endocrine diseases categories

Summaries for Insulin Autoimmune Syndrome

About this section


MalaCards based summary: Insulin Autoimmune Syndrome, also known as hereditary parkinson disease with late-onset, is related to hyperinsulinemic hypoglycemia and hyperthyroidism. An important gene associated with Insulin Autoimmune Syndrome is VPS35 (vacuolar protein sorting 35 homolog (S. cerevisiae)), and among its related pathways are Parkinsons Disease Pathway and Selected targets of GCR alpha. The compounds i-app and poly(glu(80)tyr(20)) have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Insulin Autoimmune Syndrome

About this section

Insulin Autoimmune Syndrome, Aliases & Descriptions:

Name: Insulin Autoimmune Syndrome 41 47 60
Hereditary Parkinson Disease with Late-Onset 41 47
 
Hirata Disease 41 47
Lopd 41 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

47
hereditary parkinson disease with late-onset:
Inheritance: Autosomal dominant; Age of onset: Adult,Elderly; Age of death: elderly


External Ids:

Orphanet47 411593, 411602

Related Diseases for Insulin Autoimmune Syndrome

About this section

Diseases related to Insulin Autoimmune Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1hyperinsulinemic hypoglycemia30.9INS
2hyperthyroidism30.2INSR, INS
3hypoglycemia10.6
4graves' disease10.5
5fetal macrosomia10.5INS
6parkinson disease 110.4SNCA
7rabson-mendenhall syndrome10.4INS, INSR
8leprechaunism10.3INS, INSR
9berardinelli-seip congenital lipodystrophy10.3INSR, INS
10acanthosis nigricans10.3INSR, INS
11hypoglycemic coma10.3
12polycystic ovary syndrome10.3INSR, INS
13hyperinsulinism10.3INSR, INS
14mody, type ii10.3INSR, INS
15lrrk2-related parkinson disease10.3LRRK2
16hyperandrogenism10.3INS, INSR
17lipodystrophy10.3INS, INSR
18factor v leiden thrombophilia10.2GBA, F5
19glucose intolerance10.2INS, INSR
20microvascular complications of diabetes 510.2INSR, INS
21hypertension, essential10.2INS, INSR, F5
22hypertriglyceridemia10.2INS, INSR
23stroke, ischemic10.1F5, INS
24metabolic syndrome x10.1INS, GBA, INSR
25rheumatoid arthritis10.1
26arthritis10.1
27glomerulonephritis10.1
28hepatitis10.1
29insulinoma10.1
30hepatitis c10.1
31viral hepatitis10.1
32brittle diabetes10.1
33pulmonary function10.1
34parkinson disease type 310.1LRRK2, SNCA
35essential tremor10.1LRRK2, SNCA
36supranuclear palsy, progressive10.0SNCA, LRRK2
37dementia, lewy body10.0LRRK2, SNCA
38tauopathy10.0SNCA, LRRK2
39movement disease10.0LRRK2, SNCA
40multiple system atrophy10.0LRRK2, SNCA
41dementia, frontotemporal10.0LRRK2, SNCA
42schizophrenia10.0INS, SNCA, INSR
43alzheimer disease9.8INSR, INS, LRRK2, SNCA
44dementia9.7INSR, GBA, SNCA, LRRK2
45parkinson disease, late-onset9.7SNCA, GBA, LRRK2, INSR

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to insulin autoimmune syndrome

Symptoms for Insulin Autoimmune Syndrome

About this section

Drugs & Therapeutics for Insulin Autoimmune Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Insulin Autoimmune Syndrome

Search NIH Clinical Center for Insulin Autoimmune Syndrome

Genetic Tests for Insulin Autoimmune Syndrome

About this section

Anatomical Context for Insulin Autoimmune Syndrome

About this section

MalaCards organs/tissues related to Insulin Autoimmune Syndrome:

31
Skin, T cells

Animal Models for Insulin Autoimmune Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Insulin Autoimmune Syndrome:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5SNCA, INSR, INS, LRRK2
2MP:00028738.3GBA, LRRK2, INS, VPS35, EIF4G1
3MP:00107717.9GBA, LRRK2, INS, SNCA, F5
4MP:00053847.7GBA, LRRK2, INS, INSR, GIGYF2, SNCA
5MP:00053707.7GBA, INS, INSR, F5
6MP:00053857.4GBA, LRRK2, INS, INSR, SNCA, F5
7MP:00053787.2GBA, INS, INSR, GIGYF2, SNCA, F5
8MP:00053767.1GBA, LRRK2, INS, INSR, SNCA, F5
9MP:00053866.7F5, GBA, LRRK2, INS, INSR, VPS35
10MP:00036316.7GBA, LRRK2, INS, INSR, VPS35, GIGYF2
11MP:00107686.7GBA, LRRK2, INS, INSR, VPS35, GIGYF2

Publications for Insulin Autoimmune Syndrome

About this section

Articles related to Insulin Autoimmune Syndrome:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Use of the continuous glucose monitoring system to treat insulin autoimmune syndrome: quantification of glucose excursions and evaluation of treatment efficacy. (25077287)
2014
2
Recurrent hypoglycemia from insulin autoimmune syndrome. (23979685)
2014
3
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. (25289063)
2014
4
Recurrent Insulin Autoimmune Syndrome Caused by I+-Lipoic Acid in Type 2 Diabetes. (24396698)
2013
5
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking I+-lipoic acid. (24111525)
2013
6
Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. (24190150)
2013
7
Two cases of methimazole-induced insulin autoimmune syndrome in graves' disease. (24396652)
2013
8
Insulin autoimmune syndrome in a health supplement user: the effectiveness of cornstarch therapy for treating hypoglycemia. (23370747)
2013
9
Insulin glulisine may cause a disease resembling insulin autoimmune syndrome: case report. (24265369)
2013
10
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. (24386337)
2013
11
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. (23817229)
2013
12
A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. (23843578)
2013
13
Severe hypoglycemia secondary toA methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male. (22759245)
2012
14
High prevalence of both anti-insulin and anti-insulin receptor antibodies in Korean patients with insulin autoimmune syndrome. (23000370)
2012
15
Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis. (21437150)
2008
16
The novel agent, alpha lipoic acid, can cause the development of insulin autoimmune syndrome. (17827827)
2007
17
Alpha-lipoic acid and insulin autoimmune syndrome. (17586737)
2007
18
Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. (16963149)
2007
19
Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (17329919)
2007
20
Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement. (18042740)
2007
21
Insulin autoimmune syndrome (Hirata disease) as differential diagnosis in patients with hyperinsulinemic hypoglycemia. (16670629)
2006
22
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
23
Insulin Autoimmune Syndrome (Hirata's disease): severe hypoglycemic episodes in Graves' hyperthyroidism patient treated with methimazole. (16377854)
2005
24
Insulin autoimmune syndrome: case report. (15543375)
2004
25
Hypoglycemia and transient diabetes mellitus in an insulin autoimmune syndrome]. (15143456)
2004
26
Insulin autoimmune syndrome in a patient with viral hepatitis C. (12201836)
2002
27
Hypoglycaemia due to insulin autoimmune syndrome: report of two cases with characterisation of HLA alleles and insulin autoantibodies. (11517012)
2001
28
Severe hypoglycemia due to insulin autoimmune syndrome with insulin autoantibodies crossreactive to proinsulin. (11453038)
2001
29
Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401. (11182636)
2000
30
Insulin autoimmune syndrome: a rare cause of hypoglycaemia not to be overlooked. (10592867)
1999
31
Insulin autoimmune syndrome after therapy with imipenem. (10097941)
1999
32
Recurrent hypoglycaemia caused by the insulin autoimmune syndrome: the first Dutch case. (8710037)
1996
33
A novel concept of type VII hypersensitivity introduced by insulin autoimmune syndrome (Hirata's disease) (7578882)
1995
34
Insulin autoimmune syndrome after the third therapy with methimazole. (7647412)
1995
35
Insulin autoimmune syndrome as a cause of spontaneous hypoglycemia in alcoholic cirrhosis. (7557152)
1995
36
Longitudinal changes of serum insulin concentration and insulin antibody features in persistent insulin autoimmune syndrome (Hirata's disease). (7578855)
1994
37
Insulin autoimmune syndrome in a patient with methimazole and carbimazole-treated Graves' disease: a case report. (7834559)
1994
38
Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors. (8228261)
1993
39
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)
1992
40
Insulin autoimmune syndrome and HLA-DR4. (1351232)
1992
41
Delayed disappearance of human compared to porcine insulin in a patient with the insulin autoimmune syndrome. (2407482)
1990
42
Human monoclonal IgG1 insulin autoantibody from insulin autoimmune syndrome directed at determinant at asparagine site on insulin B-chain. (2469609)
1989
43
Insulin autoimmune syndrome associated with benign monoclonal gammopathy. Evidence for monoclonal insulin autoantibodies. (2702896)
1989
44
Reverse phase high performance liquid chromatographic analysis of circulating insulin in the insulin autoimmune syndrome. (3275683)
1988
45
Rebound of antibody titer to insulin following rechallenge with thiamazole in a patient with insulin autoimmune syndrome. (3245045)
1988
46
Erythrocyte insulin receptor in insulin autoimmune syndrome: effects of corticosteroid therapy. (3554614)
1987
47
Clinical and biochemical aspects of the insulin autoimmune syndrome (IAIS). (3537496)
1986
48
Methimazole and insulin autoimmune syndrome. (6139656)
1983
49
Effects of antithyroid drugs on lymphocyte proliferative responses to lectins: relationship between insulin autoimmune syndrome and methimazole. (6689431)
1983
50
Mechanism of hypoglycemia observed in a patient with insulin autoimmune syndrome. (856650)
1977

Variations for Insulin Autoimmune Syndrome

About this section

Expression for genes affiliated with Insulin Autoimmune Syndrome

About this section
Search GEO for disease gene expression data for Insulin Autoimmune Syndrome.

Pathways for genes affiliated with Insulin Autoimmune Syndrome

About this section

Pathways related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SNCA, LRRK2
2
Show member pathways
9.3INSR, INS
39.3INSR, INS
49.3INSR, INS
59.3INSR, INS
69.3INSR, INS
79.3INS, INSR
8
Show member pathways
Insulin Pathway36
9.3INS, INSR
99.3INS, INSR
109.3INS, INSR
11
Show member pathways
9.0INS, INSR, EIF4G1
12
Show member pathways
9.0INS, INSR, EIF4G1
13
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.0EIF4G1, INSR, INS
14
Show member pathways
9.0EIF4G1, INSR, INS
15
Show member pathways
8.5SNCA, INSR, INS, LRRK2

Compounds for genes affiliated with Insulin Autoimmune Syndrome

About this section

Compounds related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1i-app439.9SNCA, INS
2poly(glu(80)tyr(20))439.8INSR, INS
3chromium picolinate439.8INSR, INS
4mecasermin43 1210.7INS, INSR
5vanadyl sulfate439.7INSR, INS
6preproinsulin439.7INS, INSR
7moxonidine439.7INSR, INS
8gliclazide43 49 1211.7INSR, INS
9glimepiride43 49 1211.7INS, INSR
10miglitol59 43 1211.7GBA, INS
11clomiphene citrate439.7INSR, INS
12aicar43 24 1211.6INSR, INS
13alpha lipoic acid439.6INSR, INS
14streptozotocin439.5INSR, INS
15fenofibrate43 49 1211.5INS, INSR
16glibenclamide43 28 49 5912.5INSR, INS
17desogestrel43 1210.4INS, F5
182-deoxyglucose43 1210.4INSR, INS
19cyproteroneacetate439.3F5, INS
20octreotide43 59 28 1212.3INS, INSR
21ly294002439.3EIF4G1, INSR, INS
22wortmannin439.3INS, INSR, EIF4G1
23protamine439.3F5, INS
24c-peptide439.2INSR, INS
25polyethylene glycol439.2F5, SNCA, INSR
26dopamine43 28 24 1212.2SNCA, INSR, LRRK2
27phosphatidylcholine439.1F5, SNCA, INSR
28rapamycin439.1INS, INSR, SNCA, EIF4G1
29phospholipid439.1GBA, SNCA, F5
30tacrolimus43 49 1211.1F5, SNCA, INS
31metformin43 49 1210.9F5, INSR, INS
32hydrocortisone43 2 59 1211.9F5, INSR, INS
33glutamine438.9F5, SNCA, INSR
34glucosylceramide43 249.8F5, GBA
35epinephrine43 24 1210.8F5, INSR, INS
36polysaccharide438.7GBA, INSR, SNCA, F5
37glycogen43 249.6F5, SNCA, INSR, INS
38glucose438.5GBA, INS, INSR, SNCA, EIF4G1
39testosterone43 59 24 1211.5INS, INSR, SNCA, F5
40cholesterol43 28 24 1211.5GBA, INS, SNCA, F5
41lipid438.4SNCA, INSR, INS, LRRK2, GBA
42cysteine438.4GBA, INSR, SNCA, F5, EIF4G1
43arginine438.3INS, INSR, SNCA, F5, EIF4G1
44glutamate438.3EIF4G1, F5, SNCA, INSR, INS
45alanine438.3INS, INSR, SNCA, F5, EIF4G1
46serine438.0GBA, INS, INSR, SNCA, F5

GO Terms for genes affiliated with Insulin Autoimmune Syndrome

About this section

Cellular components related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00080219.7SNCA, LRRK2
2inclusion bodyGO:00162349.6SNCA, LRRK2
3lysosomal membraneGO:00057659.0DNAJC13, VPS35, GBA

Biological processes related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotionGO:004001210.0SNCA, LRRK2
2adult locomotory behaviorGO:00083449.7SNCA, GIGYF2
3positive regulation of respiratory burstGO:00602679.6INSR, INS
4positive regulation of glycolytic processGO:00458219.6INS, INSR
5positive regulation of glycogen biosynthetic processGO:00457259.6INSR, INS
6activation of protein kinase B activityGO:00321489.5INS, INSR
7positive regulation of glucose importGO:00463269.5INSR, INS
8positive regulation of mitosisGO:00458409.5INSR, INS
9positive regulation of nitric oxide biosynthetic processGO:00454299.4INSR, INS
10positive regulation of DNA replicationGO:00457409.4INS, INSR
11positive regulation of protein kinase B signalingGO:00518979.3INSR, INS
12insulin receptor signaling pathwayGO:00082869.2EIF4G1, INSR, INS
13positive regulation of MAPK cascadeGO:00434109.2INSR, INS
14cell deathGO:00082199.2EIF4G1, GIGYF2, VPS35, GBA
15MAPK cascadeGO:00001659.1INS, LRRK2

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.3F5, SNCA
2insulin-like growth factor receptor bindingGO:00051599.0INSR, INS
3protein bindingGO:00055156.5EIF4G1, GBA, LRRK2, INS, INSR, VPS35

Products for genes affiliated with Insulin Autoimmune Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Insulin Autoimmune Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet