MCID: INS006
MIFTS: 38

Insulin Autoimmune Syndrome malady

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Summaries for Insulin Autoimmune Syndrome

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MalaCards based summary: Insulin Autoimmune Syndrome, also known as hirata disease, is related to hypoglycemia and hyperinsulinemic hypoglycemia. An important gene associated with Insulin Autoimmune Syndrome is INS (insulin), and among its related pathways are AMPK Enzyme Complex Pathway and FoxO signaling pathway. The compounds poly(glu(80)tyr(20)) and chromium picolinate have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are behavior/neurological and liver/biliary system.

Aliases & Classifications for Insulin Autoimmune Syndrome

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Insulin Autoimmune Syndrome, Aliases & Descriptions:

Name: Insulin Autoimmune Syndrome 42 48 62
 
Hirata Disease 42 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Insulin Autoimmune Syndrome

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Diseases related to Insulin Autoimmune Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia31.1INSR, INS
2hyperinsulinemic hypoglycemia30.7INS
3hyperthyroidism30.3INS, INSR
4insulinoma30.3INS, INSR
5diabetes mellitus30.1INSR, INS
6insulin resistance30.0INSR, INS
7graves' disease10.5
8fetal macrosomia10.4INS
9hypoglycemic coma10.3
10donohue syndrome10.2INSR, INS
11rabson-mendenhall syndrome10.1INSR, INS
12congenital generalized lipodystrophy type 210.1INS, INSR
13acanthosis nigricans10.1INSR, INS
14gestational diabetes10.1INSR, INS
15hyperandrogenism10.1INSR, INS
16lipodystrophy10.1INS, INSR
17glucose intolerance10.1INS, INSR
18diabetic retinopathy10.1INSR, INS
19hypertriglyceridemia10.1INSR, INS
20polycystic ovary syndrome10.1INSR, INS
21fatty liver disease10.1INSR, INS
22hypercholesterolemia10.1INSR, INS
23hyperinsulinism10.1INS, INSR
24essential hypertension10.1INS, INSR
25arthritis10.1
26glomerulonephritis10.1
27hepatitis10.1
28rheumatoid arthritis10.1
29hepatitis c10.1
30viral hepatitis10.1
31brittle diabetes10.1
32type 1 diabetes mellitus10.1INSR, INS
33cholera10.1INSR, INS
34metabolic syndrome x10.1INS, INSR
35hyperglycemia10.1INS, INSR
36coronary artery anomaly10.0INS, INSR
37stroke, ischemic10.0INS, F5
38galactosemia10.0F5, INS
39type 2 diabetes mellitus10.0INSR, INS
40factor v leiden thrombophilia10.0INSR, F5
41pre-eclampsia9.9F5, INSR
42vascular disease9.9F5, INS
43sepsis9.9F5, INSR
44primary hyperoxaluria9.8INSR, INS
45hypertension9.8F5, INSR, INS

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to insulin autoimmune syndrome

Symptoms for Insulin Autoimmune Syndrome

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Drugs & Therapeutics for Insulin Autoimmune Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Insulin Autoimmune Syndrome

Genetic Tests for Insulin Autoimmune Syndrome

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Anatomical Context for Insulin Autoimmune Syndrome

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MalaCards organs/tissues related to Insulin Autoimmune Syndrome:

32
Skin, T cells

Animal Models for Insulin Autoimmune Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Insulin Autoimmune Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.5F5, INSR, INS
2MP:00053708.4F5, INSR, INS
3MP:00053858.2F5, INSR, INS

Publications for Insulin Autoimmune Syndrome

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Articles related to Insulin Autoimmune Syndrome:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Use of the continuous glucose monitoring system to treat insulin autoimmune syndrome: quantification of glucose excursions and evaluation of treatment efficacy. (25077287)
2014
2
Recurrent hypoglycemia from insulin autoimmune syndrome. (23979685)
2014
3
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. (25289063)
2014
4
Recurrent Insulin Autoimmune Syndrome Caused by I+-Lipoic Acid in Type 2 Diabetes. (24396698)
2013
5
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking I+-lipoic acid. (24111525)
2013
6
Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. (24190150)
2013
7
Two cases of methimazole-induced insulin autoimmune syndrome in graves' disease. (24396652)
2013
8
Insulin autoimmune syndrome in a health supplement user: the effectiveness of cornstarch therapy for treating hypoglycemia. (23370747)
2013
9
Insulin glulisine may cause a disease resembling insulin autoimmune syndrome: case report. (24265369)
2013
10
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. (24386337)
2013
11
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. (23817229)
2013
12
A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. (23843578)
2013
13
Severe hypoglycemia secondary toA methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male. (22759245)
2012
14
High prevalence of both anti-insulin and anti-insulin receptor antibodies in Korean patients with insulin autoimmune syndrome. (23000370)
2012
15
Insulin autoimmune syndrome induced by I+-lipoic acid in a Caucasian woman: case report. (21868770)
2011
16
Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis. (21437150)
2008
17
The novel agent, alpha lipoic acid, can cause the development of insulin autoimmune syndrome. (17827827)
2007
18
Alpha-lipoic acid and insulin autoimmune syndrome. (17586737)
2007
19
Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. (16963149)
2007
20
Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (17329919)
2007
21
Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement. (18042740)
2007
22
Insulin autoimmune syndrome (Hirata disease) as differential diagnosis in patients with hyperinsulinemic hypoglycemia. (16670629)
2006
23
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
24
Insulin Autoimmune Syndrome (Hirata's disease): severe hypoglycemic episodes in Graves' hyperthyroidism patient treated with methimazole. (16377854)
2005
25
Insulin autoimmune syndrome: case report. (15543375)
2004
26
Hypoglycemia and transient diabetes mellitus in an insulin autoimmune syndrome]. (15143456)
2004
27
Insulin autoimmune syndrome in a patient with viral hepatitis C. (12201836)
2002
28
Hypoglycaemia due to insulin autoimmune syndrome: report of two cases with characterisation of HLA alleles and insulin autoantibodies. (11517012)
2001
29
Severe hypoglycemia due to insulin autoimmune syndrome with insulin autoantibodies crossreactive to proinsulin. (11453038)
2001
30
Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401. (11182636)
2000
31
Insulin autoimmune syndrome after therapy with imipenem. (10097941)
1999
32
Recurrent hypoglycaemia caused by the insulin autoimmune syndrome: the first Dutch case. (8710037)
1996
33
A novel concept of type VII hypersensitivity introduced by insulin autoimmune syndrome (Hirata's disease) (7578882)
1995
34
Insulin autoimmune syndrome after the third therapy with methimazole. (7647412)
1995
35
Insulin autoimmune syndrome as a cause of spontaneous hypoglycemia in alcoholic cirrhosis. (7557152)
1995
36
Longitudinal changes of serum insulin concentration and insulin antibody features in persistent insulin autoimmune syndrome (Hirata's disease). (7578855)
1994
37
Insulin autoimmune syndrome in a patient with methimazole and carbimazole-treated Graves' disease: a case report. (7834559)
1994
38
Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors. (8228261)
1993
39
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (1605150)
1992
40
Insulin autoimmune syndrome and HLA-DR4. (1351232)
1992
41
Delayed disappearance of human compared to porcine insulin in a patient with the insulin autoimmune syndrome. (2407482)
1990
42
Human monoclonal IgG1 insulin autoantibody from insulin autoimmune syndrome directed at determinant at asparagine site on insulin B-chain. (2469609)
1989
43
Insulin autoimmune syndrome associated with benign monoclonal gammopathy. Evidence for monoclonal insulin autoantibodies. (2702896)
1989
44
Reverse phase high performance liquid chromatographic analysis of circulating insulin in the insulin autoimmune syndrome. (3275683)
1988
45
Rebound of antibody titer to insulin following rechallenge with thiamazole in a patient with insulin autoimmune syndrome. (3245045)
1988
46
Erythrocyte insulin receptor in insulin autoimmune syndrome: effects of corticosteroid therapy. (3554614)
1987
47
Clinical and biochemical aspects of the insulin autoimmune syndrome (IAIS). (3537496)
1986
48
Methimazole and insulin autoimmune syndrome. (6139656)
1983
49
Effects of antithyroid drugs on lymphocyte proliferative responses to lectins: relationship between insulin autoimmune syndrome and methimazole. (6689431)
1983
50
Mechanism of hypoglycemia observed in a patient with insulin autoimmune syndrome. (856650)
1977

Variations for Insulin Autoimmune Syndrome

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Expression for genes affiliated with Insulin Autoimmune Syndrome

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Expression patterns in normal tissues for genes affiliated with Insulin Autoimmune Syndrome

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Pathways for genes affiliated with Insulin Autoimmune Syndrome

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Pathways related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3INSR, INS
2
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.3INSR, INS
3
Show member pathways
9.3INSR, INS
49.3INSR, INS
5
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.3INSR, INS
6
Show member pathways
9.3INSR, INS
7
Show member pathways
9.3INSR, INS
89.3INSR, INS
9
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.3INSR, INS
10
Show member pathways
9.3INSR, INS
11
Show member pathways
thioredoxin pathway37
9.3INSR, INS
129.3INSR, INS
13
Show member pathways
Insulin Pathway37
9.3INSR, INS
14
Show member pathways
9.3INSR, INS
159.3INSR, INS
169.3INSR, INS
179.3INS, INSR
18
Show member pathways
9.3INS, INSR
199.3INS, INSR
209.3INS, INSR
21
Show member pathways
9.3INS, INSR
229.3INS, INSR
239.3INS, INSR
249.3INS, INSR

Compounds for genes affiliated with Insulin Autoimmune Syndrome

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Compounds related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1poly(glu(80)tyr(20))449.8INSR, INS
2chromium picolinate449.8INSR, INS
3mecasermin44 1110.8INSR, INS
4vanadyl sulfate449.8INSR, INS
5preproinsulin449.8INS, INSR
6moxonidine449.8INSR, INS
7gliclazide44 50 1111.8INSR, INS
8glimepiride44 50 1111.8INS, INSR
9clomiphene citrate449.7INSR, INS
10aicar44 24 1111.7INSR, INS
11alpha lipoic acid449.7INS, INSR
12streptozotocin449.7INSR, INS
13fenofibrate44 50 1111.7INSR, INS
14glibenclamide44 28 50 6112.7INSR, INS
152-deoxyglucose44 1110.7INSR, INS
16octreotide44 61 28 1112.7INS, INSR
17c-peptide449.7INSR, INS
18pioglitazone28 44 50 1112.7INSR, INS
19palmitate449.6INSR, INS
20rosiglitazone28 44 50 24 1113.6INS, INSR
21troglitazone44 28 61 1112.6INSR, INS
22ibmx44 61 2811.6INSR, INS
23carbohydrates449.5INS, INSR
24thyroxine44 2410.5INSR, INS
25tunicamycin44 6110.5F5, INSR
26desogestrel44 1110.5INS, F5
27pge1449.5F5, INSR
28cyproteroneacetate449.4F5, INS
29progestin449.4INSR, F5
30protamine449.4F5, INS
31polyethylene glycol449.4F5, INSR
32glycerol44 24 1111.4INSR, INS
33citrate449.4F5, INSR
34uric acid44 2410.3F5, INS
35cyclophosphamide44 50 1111.3F5, INSR
36prostacyclin449.2INSR, F5
37polysaccharide449.1F5, INSR
38metformin44 50 1111.0F5, INSR, INS
39hydrocortisone44 2 61 1112.0INS, INSR, F5
40epinephrine44 24 1110.9F5, INSR, INS
41glycogen44 249.9F5, INSR, INS
42tacrolimus44 50 1110.9INS, F5
43creatinine448.9INS, INSR, F5
44testosterone44 61 24 1111.9F5, INSR, INS
45arginine448.9INS, INSR, F5
46glutamate448.9INS, INSR, F5
47alanine448.9F5, INSR, INS
48estrogen448.8INS, INSR, F5
49phosphatidylcholine448.8F5, INSR
50serine448.5F5, INSR, INS

GO Terms for genes affiliated with Insulin Autoimmune Syndrome

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Biological processes related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of respiratory burstGO:0602679.6INSR, INS
2positive regulation of glycolytic processGO:0458219.6INSR, INS
3positive regulation of glycogen biosynthetic processGO:0457259.6INSR, INS
4activation of protein kinase B activityGO:0321489.6INS, INSR
5positive regulation of glucose importGO:0463269.6INSR, INS
6positive regulation of mitosisGO:0458409.5INSR, INS
7positive regulation of nitric oxide biosynthetic processGO:0454299.5INSR, INS
8positive regulation of DNA replicationGO:0457409.5INS, INSR
9positive regulation of MAPK cascadeGO:0434109.4INSR, INS
10positive regulation of protein kinase B signalingGO:0518979.4INSR, INS
11glucose homeostasisGO:0425939.3INS, INSR
12G-protein coupled receptor signaling pathwayGO:0071869.3INSR, INS
13positive regulation of cell migrationGO:0303359.2INSR, INS
14insulin receptor signaling pathwayGO:0082869.0INSR, INS

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.3INSR, INS

Products for genes affiliated with Insulin Autoimmune Syndrome

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Sources for Insulin Autoimmune Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet