MCID: INS006
MIFTS: 32

Insulin Autoimmune Syndrome malady

Summaries for Insulin Autoimmune Syndrome

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33MalaCards
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MalaCards: Insulin Autoimmune Syndrome, also known as hirata disease, is related to hypoglycemia and hyperinsulinemic hypoglycemia. An important gene associated with Insulin Autoimmune Syndrome is INS (insulin), and among its related pathways are HIF-1 signaling pathway and Selenium Pathway. The compounds palmitate and desogestrel have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and thyroid, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Insulin Autoimmune Syndrome

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

insulin autoimmune syndrome 43 61
hirata disease 43


Related Diseases for Insulin Autoimmune Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Insulin Autoimmune Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.8INSR, INS
2hyperinsulinemic hypoglycemia30.1INS
3insulinoma30.0INSR, INS
4graves' disease10.5
5char syndrome10.3
6hypoglycemic coma10.2
7autoimmune hepatitis10.1
8hepatitis a10.1
9arthritis10.1
10viral hepatitis10.1
11brittle diabetes10.1
12lip disease10.1
13ovarian hyperstimulation syndrome10.0F5
14pulmonary embolism10.0F5
15myocardial infarction10.0F5
16antiphospholipid syndrome10.0F5
17hyperhomocysteinemia10.0F5
18hypogonadism10.0INS
19fetal macrosomia10.0INS
20coronary heart disease10.0INS
21diabetic ketoacidosis10.0INS
22gastroparesis10.0INS
23peripheral vascular disease10.0INS
24infertility10.0INS
25amenorrhea10.0INS
26lupus erythematosus10.0F5
27growth hormone deficiency10.0INS
28acromegaly10.0INS
29atherosclerosis10.0INS
30maturity-onset diabetes of the young10.0INS
31stroke, ischemic10.0F5
32myotonic dystrophy10.0INSR
33dementia10.0INSR
34ischemia10.0INSR
35werner syndrome10.0INSR
36morbid obesity10.0INS
37uremia10.0INSR
38thromboembolism10.0F5
39rheumatoid arthritis10.0INSR
40galactosemia10.0INS, F5
41rabson-mendenhall syndrome10.0INS, INSR
42hyperthyroidism10.0INSR, INS
43donohue syndrome10.0INSR, INS
44congenital generalized lipodystrophy type 210.0INSR, INS
45acanthosis nigricans10.0INSR, INS
46essential hypertension10.0INS, INSR
47vascular disease10.0INS, F5
48polycystic ovary syndrome10.0INSR, INS
49gestational diabetes10.0INSR, INS
50insulin resistance10.0INS, INSR

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to insulin autoimmune syndrome

Clinical Features for Insulin Autoimmune Syndrome

Drugs & Therapeutics for Insulin Autoimmune Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Insulin Autoimmune Syndrome

Drug clinical trials:

Search ClinicalTrials for Insulin Autoimmune Syndrome

Search NIH Clinical Center for Insulin Autoimmune Syndrome

Search CenterWatch for Insulin Autoimmune Syndrome

Genetic Tests for Insulin Autoimmune Syndrome

Anatomical Context for Insulin Autoimmune Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Insulin Autoimmune Syndrome:

33
Skin, Lung, Thyroid, T cells, B cells

Animal Models for Insulin Autoimmune Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Insulin Autoimmune Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5INSR, INS, F5

Publications for Insulin Autoimmune Syndrome

Sources:
51PubMed
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Articles related to Insulin Autoimmune Syndrome:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Recurrent hypoglycemia from insulin autoimmune syndrome. (23979685)
2014
2
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking I+-lipoic acid. (24111525)
2013
3
Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. (24190150)
2013
4
Two cases of methimazole-induced insulin autoimmune syndrome in graves' disease. (24396652)
2013
5
Insulin autoimmune syndrome in a health supplement user: the effectiveness of cornstarch therapy for treating hypoglycemia. (23370747)
2013
6
Insulin glulisine may cause a disease resembling insulin autoimmune syndrome: case report. (24265369)
2013
7
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. (24386337)
2013
8
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. (23817229)
2013
9
Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) syndrome is associated with severe chronic inflammation and cardiomyopathy, and represents a new monogenic autoinflammatory syndrome. (23729543)
2013
10
Type B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease. (23346003)
2013
11
Fulminant Type 1 diabetes in a pregnant woman as an initial manifestation of the insulin autoimmune syndrome. (22356444)
2012
12
Insulin autoimmune syndrome induced by I+-lipoic acid in a Caucasian woman: case report. (21868770)
2011
13
Late postprandial hypoglycemia due to bioactive insulin dissociation from autoantibody leading to unconsciousness in a patient with insulin autoimmune syndrome. (21325768)
2011
14
Drug-induced insulin autoimmune syndrome. (19070385)
2009
15
Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II. (18620562)
2008
16
Alpha-lipoic acid and insulin autoimmune syndrome. (17586737)
2007
17
Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. (17329919)
2007
18
Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement. (18042740)
2007
19
Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B. (17956452)
2007
20
Insulin autoimmune syndrome (Hirata disease) as differential diagnosis in patients with hyperinsulinemic hypoglycemia. (16670629)
2006
21
Severe hypoglycemic coma due to insulin autoimmune syndrome. (15759820)
2005
22
Insulin Autoimmune Syndrome (Hirata's disease): severe hypoglycemic episodes in Graves' hyperthyroidism patient treated with methimazole. (16377854)
2005
23
Hypoglycemia and transient diabetes mellitus in an insulin autoimmune syndrome]. (15143456)
2004
24
Distinct idiotypes of insulin autoantibody in autoimmune polyendocrine syndrome type 2 and childhood onset type 1 diabetes. (15472233)
2004
25
Insulin autoimmune syndrome in a patient with viral hepatitis C. (12201836)
2002
26
Severe hypoglycemia due to insulin autoimmune syndrome with insulin autoantibodies crossreactive to proinsulin. (11453038)
2001
27
Insulin autoimmune syndrome: the second Dutch case. (11137746)
2001
28
Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401. (11182636)
2000
29
Insulin autoimmune syndrome: a rare cause of hypoglycaemia not to be overlooked. (10592867)
1999
30
Minimal-change nephrotic syndrome and acute renal failure in a patient with aged onset insulin-dependent diabetes mellitus and autoimmune thyroiditis. (10393372)
1999
31
Remission of insulin autoimmune syndrome in a patient with Grave's disease by treatment with methimazole. (10411353)
1999
32
Recurrent hypoglycaemia caused by the insulin autoimmune syndrome: the first Dutch case. (8710037)
1996
33
Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I. (8636356)
1996
34
Insulin autoimmune syndrome after the third therapy with methimazole. (7647412)
1995
35
Insulin autoimmune syndrome as a cause of spontaneous hypoglycemia in alcoholic cirrhosis. (7557152)
1995
36
Association between antibodies to the MR 67,000 isoform of glutamate decarboxylase (GAD) and type 1 (insulin-dependent) diabetes mellitus with coexisting autoimmune polyendocrine syndrome type II. (7578849)
1994
37
Insulin autoimmune syndrome in a patient with methimazole and carbimazole-treated Graves' disease: a case report. (7834559)
1994
38
Insulin autoimmune syndrome in Japan. (7859599)
1994
39
Insulin autoimmune syndrome; HLA genes may be a marker of disease heterogeneity. (8347777)
1993
40
Strong association of insulin autoimmune syndrome with HLA-DR4. (1346661)
1992
41
HLA-DR4 genotype and insulin-processing in insulin autoimmune syndrome. (1360579)
1992
42
Insulin autoimmune syndrome is the third leading cause of spontaneous hypoglycemic attacks in Japan. (2073867)
1990
43
Human monoclonal IgG1 insulin autoantibody from insulin autoimmune syndrome directed at determinant at asparagine site on insulin B-chain. (2469609)
1989
44
Hyperglucagonemia of insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. (2659308)
1989
45
Reverse phase high performance liquid chromatographic analysis of circulating insulin in the insulin autoimmune syndrome. (3275683)
1988
46
Insulin autoimmune syndrome in methimazole or carbimazole treated Chinese patients of Graves' disease. (3265647)
1988
47
Insulin autoimmune syndrome in a methimazole-treated Graves' patient with polyclonal anti-insulin autoantibodies: report of a case. (3471860)
1987
48
Clinical and biochemical aspects of the insulin autoimmune syndrome (IAIS). (3537496)
1986
49
The syndrome of insulin resistance, acanthosis nigricans and an autoimmune disorder in diabetes mellitus treated with immunosuppressants. (6495719)
1984
50
Mechanism of hypoglycemia observed in a patient with insulin autoimmune syndrome. (856650)
1977

Genetic Variations for Insulin Autoimmune Syndrome

Expression for genes affiliated with Insulin Autoimmune Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Insulin Autoimmune Syndrome

Search GEO for disease gene expression data for Insulin Autoimmune Syndrome.

Pathways for genes affiliated with Insulin Autoimmune Syndrome

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 4Cell Signaling Technology, 53R&D Systems, 12EMD Millipore, 50PharmGKB
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Compounds for genes affiliated with Insulin Autoimmune Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 2BitterDB
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Compounds related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1palmitate4510.1INS
2desogestrel45 1110.8INS, F5
3cyproteroneacetate459.7F5, INS
4protamine459.7F5, INS
5uric acid45 2410.6F5, INS
6poly(glu(80)tyr(20))459.5INSR, INS
7chromium picolinate459.5INS, INSR
8mecasermin45 1110.5INSR, INS
9vanadyl sulfate459.5INS, INSR
10preproinsulin459.5INSR, INS
11tunicamycin45 6010.5F5, INSR
12moxonidine459.5INSR, INS
13glimepiride45 50 1111.4INSR, INS
14gliclazide45 50 1111.4INS, INSR
15pge1459.4INSR, F5
16clomiphene citrate459.4INSR, INS
17aicar45 11 2411.4INS, INSR
18progestin459.4INSR, F5
19alpha lipoic acid459.4INSR, INS
20polyethylene glycol459.4INSR, F5
21streptozotocin459.4INSR, INS
22fenofibrate45 50 1111.4INSR, INS
23glibenclamide45 29 50 6012.4INS, INSR
242-deoxyglucose45 1110.4INSR, INS
25octreotide45 60 29 1112.4INSR, INS
26c-peptide459.4INSR, INS
27pioglitazone45 50 29 1112.4INSR, INS
28citrate459.3INSR, F5
29rosiglitazone45 50 29 11 2413.3INSR, INS
30troglitazone45 29 60 1112.3INSR, INS
31cyclophosphamide45 50 1111.2F5, INSR
32ibmx45 29 6011.2INS, INSR
33tacrolimus45 50 1111.2F5, INS
34carbohydrates459.2INSR, INS
35prostacyclin459.1INSR, F5
36phosphatidylcholine459.1INSR, F5
37thyroxine45 2410.1INS, INSR
38metformin45 50 1111.0INSR, INS, F5
39hydrocortisone45 2 60 1111.9INSR, INS, F5
40epinephrine45 11 2410.9F5, INS, INSR
41glycogen45 249.9INSR, INS, F5
42creatinine458.9INSR, INS, F5
43testosterone45 60 11 2411.9INSR, INS, F5
44arginine458.9F5, INS, INSR
45alanine458.8INSR, INS, F5
46estrogen458.8F5, INS, INSR
47glycerol45 11 2410.7INSR, INS

GO Terms for genes affiliated with Insulin Autoimmune Syndrome

Sources:
16Gene Ontology
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Biological processes related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of respiratory burstGO:0602679.3INS, INSR
2positive regulation of glycolysisGO:0458219.3INS, INSR
3positive regulation of glycogen biosynthetic processGO:0457259.3INS, INSR
4activation of protein kinase B activityGO:0321489.3INS, INSR
5positive regulation of glucose importGO:0463269.2INS, INSR
6positive regulation of mitosisGO:0458409.2INS, INSR
7positive regulation of nitric oxide biosynthetic processGO:0454299.2INSR, INS
8positive regulation of DNA replicationGO:0457409.1INS, INSR
9positive regulation of MAPK cascadeGO:0434109.1INS, INSR
10positive regulation of protein kinase B signaling cascadeGO:0518979.0INS, INSR
11insulin receptor signaling pathwayGO:0082869.0INS, INSR
12glucose homeostasisGO:0425938.9INS, INSR
13positive regulation of cell migrationGO:0303358.7INSR, INS

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.0INSR, INS

Products for genes affiliated with Insulin Autoimmune Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Insulin Autoimmune Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet