MCID: INS005
MIFTS: 62

Insulin Resistance malady

Summaries for Insulin Resistance

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal... more...

MalaCards: Insulin Resistance is related to polycystic ovary syndrome and atherosclerosis. An important gene associated with Insulin Resistance is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Translation Insulin regulation of translation and Insulin Signaling. The compounds lipid and serine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and retina, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Description from OMIM:47 125853

Aliases & Classifications for Insulin Resistance

Sources:
47OMIM, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

insulin resistance 47 45 61


Related Diseases for Insulin Resistance

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Insulin Resistance family:

insulin-resistance type b

Diseases related to Insulin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.7INSR, IGF1, IGF1R, IRS1
2atherosclerosis31.5HSD11B1, TNF, IRS1, FABP2, IGF1, PTPN1
3acanthosis nigricans31.4BSCL2, AGPAT2, IGF1R, IGF1, INSR
4glucose intolerance31.3IRS1, FABP2, IGF1, INSR
5hepatitis c31.2PIK3R1, IRS1
6hyperandrogenism31.2INSR, IGF1, IGF1R
7coronary heart disease31.2FABP2, IRS1
8gestational diabetes31.1ENPP1, INSR, IRS1
9hypertriglyceridemia31.1IRS1, FABP2, BSCL2, INSR
10acromegaly30.8IGF1, HSD11B1
11hyperinsulinism30.7IRS1, IGF1, INSR
12uremia30.6IGF1, INSR, ENPP1
13rabson-mendenhall syndrome30.6INSR, IGF1
14hypoglycemia30.6IGF1, INSR
15hypercholesterolemia30.6INSR, FABP2
16werner syndrome30.6INSR
17adenoma30.4INSR, IGF2R, IGF1, IGF1R, HSD11B1
18alzheimer's disease30.4PIK3R1, INSR, PTPN1
19familial partial lipodystrophy30.4AGPAT2, BSCL2
20colorectal cancer30.3IRS1, IGF1R, IGF1, IGF2R, INSR
21growth hormone deficiency30.3IGF1
22congenital generalized lipodystrophy type 230.1INSR, AGPAT2, BSCL2
23metabolic syndrome x30.1HSD11B1
24type 2 diabetes mellitus29.9INSR, IRS1
25pituitary tumors29.9IGF1
26n syndrome11.0
27fatty liver disease10.9
28insulin-resistance type b10.9
29coronary artery disease,10.8
30hepatitis a10.7
31nonalcoholic steatohepatitis10.6
32morbid obesity10.6
33bod syndrome10.6
34cardiovascular disease risk factor10.6
35young syndrome10.6
36hepatitis c virus10.6
37hepatitis d10.5
38familial combined hyperlipidemia10.5
39arthritis10.5
40estrogen resistance10.5
41adult syndrome10.5
42vascular disease10.5
43micro syndrome10.5
44cortisol resistance10.5
45lip disease10.5
46mass syndrome10.5
47sleep apnea10.5
48hepatitis e10.5
49char syndrome10.5
50glucocorticoid resistance10.5

Graphical network of the top 20 diseases related to Insulin Resistance:



Diseases related to insulin resistance

Clinical Features for Insulin Resistance

Sources:
47OMIM
See all sources

Clinical features from OMIM:

125853

Drugs & Therapeutics for Insulin Resistance

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Insulin Resistance

Drug clinical trials:

Search ClinicalTrials for Insulin Resistance

Search NIH Clinical Center for Insulin Resistance

Search CenterWatch for Insulin Resistance

Genetic Tests for Insulin Resistance

Anatomical Context for Insulin Resistance

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Insulin Resistance:

33
Whole blood, Brain, Retina, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Placenta, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Hypothalamus, Amygdala, Cardiac myocytes, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Pituitary

Animal Models for Insulin Resistance or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Insulin Resistance:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537813.6CIDEC, PIK3R1, BSCL2, FABP2, IRS1, TNF
2MP:000537613.4CIDEC, PIK3R1, BSCL2, FABP2, IRS1, TNF
3MP:000538612.9HSD11B1, TNF, BSCL2, CIDEC, AGPAT2, IGF1R
4MP:001076812.8AGPAT2, PIK3R1, BSCL2, IRS1, TNF, IGF1R
5MP:000537012.7HSD11B1, TNF, IRS1, FABP2, BSCL2, PIK3R1
6MP:000538412.7HSD11B1, TNF, IRS1, BSCL2, PIK3R1, IGF1R
7MP:000538712.5BSCL2, IRS1, TNF, HSD11B1, PIK3R1, AGPAT2
8MP:000538512.3HSD11B1, TNF, IRS1, BSCL2, PIK3R1, IGF1R
9MP:000539712.3BSCL2, IRS1, TNF, HSD11B1, PIK3R1, AGPAT2
10MP:000537511.9ENPP1, HSD11B1, FABP2, BSCL2, CIDEC, IGF1R
11MP:000363111.9TNF, IGF1R, IGF1, IGF2R, INSR, PTPRF
12MP:000539011.9IGF1R, IGF1, IGF2R, SLC27A4, PTPRF, PTPN1
13MP:001077111.9BSCL2, CIDEC, AGPAT2, IGF1R, SLC27A4, PTPRF
14MP:000536711.7FABP2, BSCL2, AGPAT2, IGF1, IGF2R, INSR
15MP:000536911.6IRS1, PIK3R1, IGF1R, IGF1, INSR, ENPP1
16MP:000538111.6TNF, BSCL2, AGPAT2, IGF1R, INSR, SLC27A4
17MP:000538811.4HSD11B1, IGF1R, IGF1, IGF2R, INSR
18MP:000537911.3TNF, IRS1, PTPRF, PTPN1
19MP:000538211.1TNF, AGPAT2, IGF1R, IGF2R, SLC27A4, PTPRF
20MP:000537110.7IGF2R, AGPAT2

Publications for Insulin Resistance

Sources:
51PubMed
See all sources

Articles related to Insulin Resistance:

(show top 50)    (show all 4894)
idTitleAuthorsYear
1
Preventative Effect of Zingiber Officinale on Insulin Resistance in a High-Fat, High-Carbohydrate Diet-Fed Rat Model and its Mechanism of Action. (24428842)
2014
2
Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. (23894207)
2013
3
Insulin-Resistance-Associated Compensatory Mechanisms of Pancreatic Beta Cells: A Current Opinion. (24133484)
2013
4
MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2. (23954742)
2013
5
Camel milk ameliorates steatohepatitis, insulin resistance and lipid peroxidation in experimental non-alcoholic fatty liver disease. (24119413)
2013
6
Cardiometabolic risk factors and insulin resistance in obese children and adolescents: relation to puberty. (24227418)
2013
7
Possible role of microsomal epoxide hydrolase gene polymorphism as a risk factor for developing insulin resistance and type 2 diabetes mellitus. (22555758)
2012
8
Interleukin-1I^ interferes with epidermal homeostasis through induction of insulin resistance: implications for psoriasis pathogenesis. (22513786)
2012
9
Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. (21613355)
2011
10
Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. (21595894)
2011
11
Association of SUMO4 Met55Val variation with increased insulin resistance in newly diagnosed type 2 diabetes in a Chinese population. (21671169)
2011
12
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. (21881966)
2011
13
Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension. (20444953)
2010
14
Hypoadiponectinemia--cause or consequence of human "insulin resistance"? (20164291)
2010
15
Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. (19208729)
2009
16
Maternal plasma cytokines concentrations and insulin resistance in first trimester in relation to fetal growth. (20038928)
2009
17
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. (18288188)
2008
18
Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia. (18556574)
2008
19
Nuclear receptors and human disease: resistance to thyroid hormone and lipodystrophic insulin resistance. (18430406)
2008
20
Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. (18666225)
2008
21
Adiponectin and its association with insulin resistance and type 2 diabetes. (18571119)
2008
22
Factors responsible for the evolution of insulin resistance in Japanese type 2 diabetic patients: association with atherosclerosis. (17532086)
2007
23
IGF-binding protein-2 protects against the development of obesity and insulin resistance. (17259371)
2007
24
Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type). (17560154)
2007
25
Age- and body mass index-dependent relationship between correction of iron deficiency anemia and insulin resistance in non-diabetic premenopausal women. (17921683)
2007
26
Biological background and role of adiponectin as marker for insulin resistance and cardiovascular risk. (16285470)
2005
27
Pharmacologic therapies for acromegaly: a review of their effects on glucose metabolism and insulin resistance. (15649100)
2005
28
Gender differences in association of plasma adiponectin with obesity reflect resultant insulin resistance in non-diabetic Japanese patients with schizophrenia. (15896219)
2005
29
The role of insulin resistance and resistin in pathogenesis of diabetes mellitus with special attention to diabetes in pregnancy]. (16363386)
2005
30
Development and progression of atherosclerotic disease in relation to insulin resistance and hyperinsulinemia. (16392771)
2005
31
Impact of common polymorphisms in candidate genes for insulin resistance and obesity on weight loss of morbidly obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet. (15985484)
2005
32
Should we routinely measure a proxy for insulin resistance as well as improve our modelling techniques to better predict the likelihood of coronary heart disease in people with type 2 diabetes. (15171756)
2004
33
Insulin resistance and endothelial dysfunction in the brothers of Indian subcontinent Asian women with polycystic ovaries. (15008997)
2004
34
Insulin resistance in HIV-related lipodystrophy. (12642010)
2003
35
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. (14511928)
2003
36
Insulin resistance highly associates with hypertension in IgA nephropathy. (12608549)
2003
37
Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma. (11334412)
2001
38
Correction of hyperglycaemia reduces insulin resistance and serum soluble E-selectin levels in patients with Type 2 diabetes mellitus. (11318844)
2001
39
Association of the Pro90Ser CD36 mutation with elevated free fatty acid concentrations but not with insulin resistance syndrome in Japanese. (11718687)
2001
40
Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. (9222647)
1997
41
Epidemiology of hypertension and insulin resistance syndrome. (9050982)
1997
42
Perspective in the treatment of insulin resistance. (9403322)
1997
43
Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. (9032102)
1997
44
Insulin resistance and advancing age: what role for dehydroepiandrosterone sulfate? (9361686)
1997
45
Insulin resistance in limb and trunk partial lipodystrophy (type 2 KAPbberling-Dunnigan syndrome). (9030822)
1997
46
Insulin resistance in cardiac syndrome X and variant angina: influence of physical capacity and circulating lipids. (9313602)
1997
47
Relation of components of insulin resistance syndrome to coronary disease risk. (7981959)
1994
48
Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome. (8334748)
1993
49
Role of impaired intracellular glucose metabolism in the insulin resistance of aging. (1406297)
1992
50
Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history. (2933497)
1985

Genetic Variations for Insulin Resistance

Expression for genes affiliated with Insulin Resistance

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Insulin Resistance

Search GEO for disease gene expression data for Insulin Resistance.

Pathways for genes affiliated with Insulin Resistance

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 4Cell Signaling Technology, 54Reactome, 53R&D Systems, 50PharmGKB, 60Tocris Bioscience
See all sources

Pathways related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Translation Insulin regulation of translation
Hide members
11.8TNF, IRS1, PIK3R1, IGF1R, IGF1, INSR
211.6IRS1, PIK3R1, IGF1R, INSR, PTPRF, PTPN1
3
Hide members
11.6TNF, PIK3R1, IGF1R, IGF1, IGF2R, PTPRF
4
Hide members
11.6TNF, IRS1, PIK3R1, IGF1R, IGF1, IGF2R
511.6IRS1, IGF1R, IGF2R, INSR, PTPN1, ENPP1
6
Hide members
11.4TNF, IRS1, PIK3R1, IGF1R, IGF1, INSR
7
Hide members
11.4TNF, IRS1, PIK3R1, IGF1R, IGF1, INSR
811.4IGF1, IRS1, BSCL2, LPIN2, LPIN3, AGPAT2
9
Hide members
11.4PIK3R1, IGF1R, IGF1, IGF2R, INSR, PTPN1
10
Hide members
11.4IRS1, PIK3R1, IGF1R, IGF1, IGF2R, INSR
11
Hide members
11.4TNF, PIK3R1, IGF1R, IGF1, IGF2R, INSR
12
Hide members
11.3TNF, IRS1, PIK3R1, IGF1R, IGF1
1311.3IRS1, PIK3R1, IGF1R, IGF1, INSR
14
Development Ligand-independent activation of ESR1 and ESR2
Hide members
11.3IRS1, PIK3R1, IGF1R, IGF1, INSR
15
Hide members
11.3IRS1, PIK3R1, IGF1R, IGF1, INSR
16
Hide members
11.3IRS1, PIK3R1, IGF1R, IGF1, INSR
17
Hide members
11.3IRS1, PIK3R1, IGF1R, IGF1, INSR
18
Hide members
11.3TNF, PIK3R1, IGF1R, IGF1, INSR
19
Hide members
11.3INSR, IGF2R, IGF1, IGF1R, PIK3R1
2011.1PTPN1, IGF1R, PIK3R1, IRS1
21
Hide members
11.1IRS1, PIK3R1, IGF1R, IGF1
22
Development Dopamine D2 receptor transactivation of EGFR
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11.1IGF1, IGF1R, PIK3R1, IRS1
23
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11.1IGF1, IGF1R, PIK3R1, IRS1
24
Transcription Androgen Receptor nuclear signaling
Hide members
11.1IRS1, PIK3R1, IGF1R, IGF1
25
Hide members
11.1IRS1, PIK3R1, IGF1R, IGF1
26
Hide members
11.1IRS1, PIK3R1, IGF1R, IGF1
2711.1IRS1, PIK3R1, INSR, PTPN1
2811.1PTPN1, INSR, PIK3R1, IRS1
29
Apoptosis and survival Caspase cascade
Hide members
11.1TNF, IRS1, IGF1R, IGF1
3011.1PTPN1, PTPRF, INSR, IGF1R
3111.1TNF, PIK3R1, IGF1R, IGF1
32
Hide members
11.1TNF, PIK3R1, IGF1R, IGF1
3311.1IRS1, PIK3R1, IGF1, INSR
34
Hide members
11.1TNF, IRS1, PIK3R1, INSR
35
Hide members
11.1INSR, PIK3R1, IRS1, TNF
3611.1PIK3R1, IGF1R, IGF1, INSR
37
Hide members
11.1AGPAT2, LPIN3, LPIN2, PIK3R1
3811.1PIK3R1, IGF1R, IGF2R, INSR
39
Hide members
11.1PIK3R1, IGF1R, IGF2R, INSR
40
Hide members
11.1PIK3R1, IGF1R, IGF2R, INSR
41
Development Leptin signaling via PI3K-dependent pathway
Hide members
11.0IRS1, PIK3R1, PTPN1
4211.0IRS1, IGF1R, IGF1
4311.0IRS1, PIK3R1, IGF1R
4411.0ENPP1, IGF1, IGF1R
4511.0PIK3R1, INSR, PTPN1
4611.0FABP2, AGPAT2, SLC27A4
4711.0INSR, IGF1, IGF1R
48
Hide members
11.0AGPAT2, LPIN3, LPIN2
4911.0AGPAT2, LPIN3, LPIN2
5010.8PIK3R1, TNF

Compounds for genes affiliated with Insulin Resistance

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1lipid4512.7IRS1, PIK3R1, TNF, AGPAT2, IGF2R, INSR
2serine4512.5INSR, IGF1, IRS1, TNF, PIK3R1, IGF1R
3tyrosine4512.5PTPN1, HSD11B1, PTPRF, ENPP1, INSR, IGF1
4glycogen45 2413.4IGF1R, ENPP1, IRS1, HSD11B1, PTPN1, INSR
5threonine4512.4IGF2R, PTPN1, ENPP1, IGF1R, PIK3R1, FABP2
6glucose4512.2IGF2R, IGF1R, IRS1, INSR, ENPP1, PEA15
7phosphatidylinositol4512.2PEA15, ENPP1, PTPN1, IGF1, IGF1R, PIK3R1
8h2o24512.0PTPRF, PTPN1, INSR, IGF1R, PIK3R1, IRS1
9testosterone45 60 11 2415.0PIK3R1, IGF1, INSR, PTPN1, IRS1, HSD11B1
10cholesterol45 29 11 2415.0HSD11B1, IGF2R, IGF1, IGF1R, PIK3R1, FABP2
11phenylalanine4511.9PTPN1, INSR, IGF1R, FABP2, IRS1, PIK3R1
12dexamethasone45 50 29 1114.9IGF1R, PIK3R1, IRS1, INSR, ENPP1, HSD11B1
13phosphotyrosine4511.9IGF1R, PIK3R1, IRS1, INSR, PTPRF, PTPN1
14rapamycin4511.8IGF1, IRS1, INSR, ENPP1, IGF1R, PIK3R1
15pd 98,0594511.8INSR, IGF1, IGF1R, PIK3R1, IRS1, TNF
16ly2940024511.8IGF1R, PIK3R1, IRS1, TNF, INSR, IGF1
17wortmannin4511.8PIK3R1, IGF1R, IGF1, IGF2R, INSR, IRS1
18genistein45 29 60 2 11 2416.8TNF, PIK3R1, IGF1R, IGF1, IRS1, INSR
19glutamine4511.8HSD11B1, IGF1R, INSR, IGF1, ENPP1, PTPN1
20thymidine45 2412.7IRS1, PIK3R1, TNF, IGF1R, INSR, IGF1
212-deoxyglucose45 1112.7INSR, PIK3R1, IGF1R, IGF1, IRS1
22metformin45 50 1113.7IGF1, INSR, PTPN1, ENPP1, IRS1
23pioglitazone45 50 29 1114.7PTPN1, INSR, IRS1, HSD11B1, TNF
24rosiglitazone45 50 29 11 2415.7INSR, IRS1, TNF, HSD11B1, PTPN1
25okadaic acid45 6012.6PTPN1, IRS1, PIK3R1, IGF1R, IGF2R
26demethylasterriquinone b16011.6IGF1, IGF1R, IGF2R, INSR
27picropodophyllotoxin6011.6IGF2R, IGF1, IGF1R, INSR
28insulin (human) recombinant6011.6INSR, IGF2R, IGF1, IGF1R
29bms 5369246011.6IGF2R, INSR, IGF1, IGF1R
30mecasermin45 1112.6IGF1R, INSR, IGF2R, IGF1
31ag 10244511.6IGF1, INSR, IRS1, IGF1R
32sb 20358045 6012.5IGF1, IRS1, TNF, PIK3R1, INSR
33phosphoserine45 2412.5PTPN1, IRS1, IGF1R, INSR
34c-peptide4511.5INSR, IGF1, IGF1R, IRS1
35vegf4511.4IGF1, IGF1R, PIK3R1, TNF, INSR, IGF2R
36chloroquine45 2 50 29 1115.4INSR, IGF2R, IGF1R, TNF
37progestin4511.4PIK3R1, INSR, IGF1, IGF1R
38lactacystin4511.4TNF, IRS1, INSR, IGF1R
39mannose 6-phosphate45 2412.3IGF2R, IGF1, IGF1R, INSR
40vanadium4511.3IRS1, INSR, PTPN1
41hydrocortisone45 2 60 1114.3INSR, TNF, HSD11B1, IGF1
42actinomycin d4511.3IGF1R, IGF1, TNF, INSR, IRS1
43clomiphene citrate4511.2INSR, IGF1, IGF1R
44ibmx45 29 6013.2IGF1R, IGF1, INSR, IRS1
45estrogen4511.0HSD11B1
46[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID1111.0IRS1, INSR
47Insulin Glargine1110.9INSR, IGF1R
48Insulin Lispro1110.9INSR, IGF1R
49sodium orthovanadate45 6011.9PTPN1, IRS1, INSR
50sterol4510.8PTPN1, PIK3R1, HSD11B1, IRS1

GO Terms for genes affiliated with Insulin Resistance

Sources:
16Gene Ontology
See all sources

Cellular components related to Insulin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.1IRS1, FABP2, PIK3R1, IGF1R, IGF1, INSR
2endoplasmic reticulum membraneGO:00578911.3PTPN1, SLC27A4, AGPAT2, LPIN3, LPIN2, HSD11B1
3insulin receptor complexGO:00589910.8INSR, IRS1
4caveolaGO:00590110.7IRS1, IGF1R, INSR

Biological processes related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor signaling pathwayGO:04800911.7IGF2R, IGF1, IGF1R, PIK3R1, IRS1
2insulin receptor signaling pathwayGO:00828611.6IRS1, PIK3R1, IGF1R, INSR, PTPN1
3positive regulation of glucose importGO:04632611.5IRS1, PIK3R1, IGF1, INSR
4positive regulation of protein kinase B signaling cascadeGO:05189711.5TNF, IGF1R, IGF1, INSR
5positive regulation of cell migrationGO:03033511.4IRS1, PIK3R1, IGF1R, INSR
6phosphatidylinositol-mediated signalingGO:04801511.4IGF1, IGF1R, PIK3R1, IRS1
7phospholipid metabolic processGO:00664411.3AGPAT2, LPIN3, LPIN2, PIK3R1
8negative regulation of glucose importGO:04632511.3TNF, ENPP1, PEA15
9exocrine pancreas developmentGO:03101711.3IGF1R, IGF1, INSR
10positive regulation of glycogen biosynthetic processGO:04572511.3INSR, IGF1, IRS1
11mammary gland developmentGO:03087911.3IGF1, IGF1R, IRS1
12phosphatidylinositol 3-kinase cascadeGO:01406511.3IRS1, PIK3R1, IGF1R
13negative regulation of insulin receptor signaling pathwayGO:04662711.3ENPP1, PTPN1, IRS1
14positive regulation of mitosisGO:04584011.3INSR, IGF1, TNF
15positive regulation of DNA replicationGO:04574011.2IGF1R, IGF1, INSR
16fatty acid metabolic processGO:00663111.2LPIN3, LPIN2, FABP2
17cellular response to insulin stimulusGO:03286911.1IRS1, INSR, ENPP1
18positive regulation of MAPK cascadeGO:04341011.1INSR, IGF1, IGF1R
19sequestering of triglycerideGO:03073011.1ENPP1, TNF
20lipid particle organizationGO:03438910.9CIDEC, BSCL2
21positive regulation of glycolysisGO:04582110.9IGF1, INSR
22glycerophospholipid biosynthetic processGO:04647410.9AGPAT2, LPIN3, LPIN2
23male sex determinationGO:03023810.8IGF1R, INSR
24negative regulation of lipid catabolic processGO:05099510.8BSCL2, TNF
25phosphatidylethanolamine biosynthetic processGO:00664610.5LPIN3, LPIN2

Molecular functions related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:00515811.7ENPP1, PTPN1, IGF1, IGF1R, PIK3R1, IRS1
2insulin-like growth factor receptor bindingGO:00515911.3IRS1, PIK3R1, IGF1, INSR
3phosphatidylinositol 3-kinase bindingGO:04354811.3INSR, IGF1R, PIK3R1, IRS1
4insulin bindingGO:04355911.1PIK3R1, IGF1R, INSR
5insulin receptor substrate bindingGO:04356011.0INSR, IGF1R, PIK3R1
6insulin-like growth factor-activated receptor activityGO:00501010.8IGF2R, IGF1R
7phosphatidate phosphatase activityGO:00819510.8LPIN3, LPIN2
8insulin-like growth factor I bindingGO:03199410.7IGF1R, INSR
9transmembrane receptor protein tyrosine kinase adaptor activityGO:00506810.5PIK3R1, IRS1

Products for genes affiliated with Insulin Resistance

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Insulin Resistance

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet