MCID: INS005
MIFTS: 65

Insulin Resistance malady

Genetic diseases, Rare diseases, Endocrine diseases categories
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Summaries for Insulin Resistance

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Wikipedia:65 Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal... more...

MalaCards based summary: Insulin Resistance is related to polycystic ovary syndrome and glucose intolerance. An important gene associated with Insulin Resistance is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are ERK Signaling and Type II diabetes mellitus. The compounds glucose and glycogen have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and skeletal muscle, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Description from OMIM:46 125853

Aliases & Classifications for Insulin Resistance

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Insulin Resistance, Aliases & Descriptions:

Name: Insulin Resistance 46 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Related Diseases for Insulin Resistance

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Diseases in the Insulin Resistance family:

Insulin-Resistance Type B

Diseases related to Insulin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome32.7CAPN10, IRS1, INSR
2glucose intolerance32.4INSR, PAX4, RETN, CAPN10, SLC2A4
3obesity32.4HNF4A, CAPN10, IL6, RETN, IRS1, LIPC
4hyperandrogenism32.3INSR, RETN, CAPN10
5essential hypertension32.2INSR, PTPN1, RETN, GCGR
6lipodystrophy32.2RETN, AKT2, INSR
7atherosclerosis32.1PTPN1, LIPC, IRS1, TCF7L2, RETN, IL6
8fatty liver disease32.1INSR, LIPC, RETN, HNF4A
9type 2 diabetes mellitus32.0GPD2
10hypertriglyceridemia31.9INSR, LIPC, IRS1, SLC2A4
11gestational diabetes31.8ABCC8, INSR, IRS1, SLC2A4, HNF4A, CAPN10
12hyperinsulinism31.6ABCC8, INSR, IRS1, RETN
13liver cirrhosis31.5INSR, IRS1, RETN, SLC2A4
14diabetes mellitus31.5SLC2A2, SLC2A4, GCGR, HNF4A, HNF1B, CAPN10
15uremia31.4INSR, LIPC, RETN
16hypercholesterolemia31.4INSR, LIPC, RETN, CAPN10
17sepsis31.3INSR, IRS1, RETN, IL6, SLC2A4
18breast cancer31.2INSR, PTPN1, IRS1, TCF7L2, AKT2, HNF4A
19pre-eclampsia31.2IL6, RETN, LIPC, INSR
20metabolic syndrome x31.1ABCC8, INSR, PTPN1, RETN, CAPN10, HNF4A
21hypoglycemia31.0ABCC8, INSR, HNF4A, GCGR, SLC2A4, SLC2A2
22hyperglycemia30.9SLC2A2, SLC2A4, GCGR, HNF4A, HNF1B, RETN
23pancreatic cancer30.9IRS1, AKT2, HNF4A, SLC2A4
24colorectal cancer30.9PPP1R3A, INSR, IRS1, TCF7L2, HNF4A
25type 1 diabetes mellitus30.9INSR, PAX4, LIPC, NEUROD1, RETN, HNF4A
26prostate cancer30.7INSR, IRS1, TCF7L2, AKT2, IL6, MAPK8IP1
27ischemia30.5ABCC8, INSR, MAPK8IP1, SLC2A4
28insulinoma30.5ABCC8, GPD2, INSR, PAX4, HNF4A, SLC2A2
29maturity-onset diabetes of the young30.4PAX4, NEUROD1, HNF1B, HNF4A
30adenocarcinoma30.4INSR, NEUROD1, AKT2, HNF1B, HNF4A, SLC2A4
31liver cancer30.1INSR, LIPC, IRS1, TCF7L2, IL6, HNF1B
32hypertension11.2
33hepatitis11.1
34acanthosis nigricans11.0
35liver disease11.0
36endotheliitis10.9
37hepatitis c10.9
38artery disease10.8
39kidney disease10.7
40hepatitis c virus10.7
41pancreatitis10.6
42nonalcoholic steatohepatitis10.6
43morbid obesity10.6
44arthritis10.6
45acromegaly10.6
46familial combined hyperlipidemia10.6
47congenital heart disease10.6SLC2A4, IL6, RETN, INSR
48thyroiditis10.5
49rheumatoid arthritis10.5
50sleep apnea10.5

Graphical network of the top 20 diseases related to Insulin Resistance:



Diseases related to insulin resistance

Symptoms for Insulin Resistance

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Clinical features from OMIM:

125853

Drugs & Therapeutics for Insulin Resistance

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Drug clinical trials:

Search ClinicalTrials for Insulin Resistance

Search NIH Clinical Center for Insulin Resistance

Genetic Tests for Insulin Resistance

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Anatomical Context for Insulin Resistance

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MalaCards organs/tissues related to Insulin Resistance:

32
Ovary, Liver, Skeletal muscle, Adipocyte, Heart, Endothelial, Kidney, Pancreas, Testes, Monocytes, Bone, Thyroid, Breast, Brain, Skin, Prostate, Colon, Smooth muscle, B cells, Pituitary, Lung, T cells, Small intestine, Myeloid, Neutrophil, Eye, Cortex, Retina, Salivary gland, Placenta, Hypothalamus, Amygdala, Pancreatic islet, Spinal cord

Animal Models for Insulin Resistance or affiliated genes

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MGI Mouse Phenotypes related to Insulin Resistance:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.2HNF4A, GPD2, ABCC8, PPP1R3A, INSR, PTPN1
2MP:000537911.1ABCC8, INSR, GPD2, SLC2A2, SLC2A4, GCGR
3MP:000537811.0IL6, PPP1R3A, SLC2A2, SLC2A4, GCGR, HNF4A
4MP:000537511.0SLC2A4, GCGR, CAPN10, IL6, RETN, AKT2
5MP:000537010.9IRS1, TCF7L2, AKT2, RETN, INSR, IL6
6MP:001076810.9MAPK8IP1, IL6, AKT2, IRS1, NEUROD1, PAX4
7MP:000536910.7SLC2A4, HNF1B, IL6, TCF7L2, AKT2, IRS1
8MP:000363110.7AKT2, INSR, NEUROD1, IL6, MAPK8IP1, HNF4A
9MP:000538410.6SLC2A2, NEUROD1, INSR, IRS1, TCF7L2, AKT2
10MP:000538610.4GPD2, INSR, PTPN1, MAPK8IP1, IL6, NEUROD1

Publications for Insulin Resistance

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Articles related to Insulin Resistance:

(show top 50)    (show all 5087)
idTitleAuthorsYear
1
Accuracy and precision of commonly used methods for quantifying surgery-induced insulin resistance: Prospective observational study. (24257458)
2014
2
Nonalcoholic Fatty Liver Disease and Hyperuricemia: A Close Relation with Hepatic Insulin Resistance after Nicotinic Acid Treatment? (25350520)
2014
3
The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. (23649472)
2014
4
Correction: Overexpressing STAMP2 Improves Insulin Resistance in Diabetic ApoE(-/-)/LDLR(-/-) Mice via Macrophage Polarization Shift in Adipose Tissues. (24391692)
2013
5
The Severity of Menstrual Dysfunction as a Predictor of Insulin Resistance in PCOS. (24092831)
2013
6
Association between I^2-adrenoceptor (ADRB2) haplotypes and insulin resistance in PCOS. (22900502)
2013
7
PPARG2 Pro12Ala and ADAMTS9 rs4607103 as "insulin resistance loci" and "insulin secretion loci" in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4. (23161442)
2013
8
Wrist breadth and homeostasis model assessment of insulin resistance in youth: the Fels Longitudinal Study. (23897560)
2013
9
Heat Shock Prevents Insulin Resistance Induced Vascular Complications By Augmenting Angiotensin-(1-7) Signalling. (24270982)
2013
10
Association between insulin resistance and sustained virologic response in hepatitis C treatment, genotypes 1 versus 2 and 3: systematic literature review and meta-analysis. (24055394)
2013
11
Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. (23560057)
2013
12
High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients. (22136974)
2012
13
Increased insulin resistance and C-reactive protein in women with complete hydatidiform mole. (21204606)
2011
14
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
15
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
16
Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. (20107300)
2010
17
Insulin resistance and overweight-obese women with polycystic ovary syndrome. (19903118)
2010
18
The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes. (19139803)
2009
19
Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases. (19146801)
2009
20
Role of mitochondrial dysfunction in insulin resistance. (18309108)
2008
21
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. (18443205)
2008
22
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
23
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
24
Resistin: a hormone which induces insulin resistance is increased in normal pregnancy. (17919114)
2007
25
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
26
Insulin resistance and atherosclerosis. (16823479)
2006
27
Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance. (16478779)
2006
28
Association of inflammatory marker and highly sensitive C-reactive protein with aerobic exercise capacity, maximum oxygen uptake and insulin resistance in healthy middle-aged volunteers. (15791041)
2005
29
Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. (16034720)
2005
30
Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. (16182246)
2005
31
Molecular mechanisms of impaired endothelial function associated with insulin resistance. (15032648)
2004
32
Should we routinely measure a proxy for insulin resistance as well as improve our modelling techniques to better predict the likelihood of coronary heart disease in people with type 2 diabetes. (15171756)
2004
33
Inflammation, insulin resistance, and adiposity: a study of first-degree relatives of type 2 diabetic subjects. (15277436)
2004
34
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
35
Unraveling the mysteries of syndrome X. As the number of Americans with insulin resistance grows, pharmacists can help patients prevent the onset of type 2 diabetes and cardiovascular disease. (14626524)
2003
36
Relationship of insulin resistance and overweight with cortisol and dehydroepiandrosterone-sulfate levels. (12505096)
2002
37
Insulin-regulated transcription factors: molecular link between insulin resistance and cardiovascular risk factors. (11466584)
2001
38
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
39
Serum leptin concentrations in young insulin-sensitive and insulin-resistant volunteers. (10965933)
2000
40
Remodeling of the endocrine pancreas: the central role of amylin and insulin resistance. (10653060)
2000
41
AlstrAPm syndrome with subclinical insulin-resistant diabetes and hepatic dysfunction: a family report. (10845422)
2000
42
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine. (10574416)
1999
43
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
44
Components of the insulin resistance syndrome are associated with progression of atherosclerosis in non-grafted arteries 5 years after coronary artery bypass surgery. (9717003)
1998
45
Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. (9222647)
1997
46
Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. (9056694)
1997
47
Epidemiology of hypertension and insulin resistance syndrome. (9050982)
1997
48
Insulin resistance in insulin-dependent diabetic patients with microalbuminuria. (8105164)
1993
49
Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle. (1547918)
1992
50
Association of specific histocompatibility antigens and acanthosis nigricans with insulin resistance. (2101060)
1990

Variations for Insulin Resistance

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UniProtKB/Swiss-Prot genetic disease variations for Insulin Resistance:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Insulin Resistance:

6 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
3ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
4PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
5AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
6SLC30A8NM_173851.2(SLC30A8): c.412C> T (p.Arg138Ter)single nucleotide variantprotectivers200185429GRCh37Chr 8, 118165323: 118165323
7SLC30A8NM_173851.2(SLC30A8): c.101_107delAAGATCA (p.Lys34Serfs)deletionprotectiveGRCh37Chr 8, 118159222: 118159228
8LIPCLIPC, -250G-Asingle nucleotide variantrisk factor
9INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
10INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
11IL6IL6, -174G-Csingle nucleotide variantrisk factor
12GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
13SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
14GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
15IGF2BP2NM_006548.4(IGF2BP2): c.239+29254C> Asingle nucleotide variantrisk factorrs4402960GRCh37Chr 3, 185511687: 185511687
16IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
17IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
18HMGA1HMGA1, 1-BP INS, IVS5, -13insertionrisk factor
19RETNRETN, +62G-Asingle nucleotide variantrisk factor
20CAPN10NM_023083.3(CAPN10): c.471-176G> Asingle nucleotide variantrisk factorrs3792267GRCh37Chr 2, 241531174: 241531174
21CAPN10CAPN10, IVS6, INS/DEL, 39-BPindelrisk factor
22CAPN10CAPN10, IVS13, g.16378G-Tsingle nucleotide variantrisk factor
23CAPN10CAPN10, IVS3, g.4841T-Csingle nucleotide variantrisk factor
24MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
25TCF7L2NM_030756.4(TCF7L2): c.382-41435C> Tsingle nucleotide variantrisk factorrs7903146GRCh37Chr 10, 114758349: 114758349
26TCF7L2NM_030756.4(TCF7L2): c.483+9017G> Tsingle nucleotide variantrisk factorrs12255372GRCh37Chr 10, 114808902: 114808902
27TCF7L2NM_030756.4(TCF7L2): c.483+7162G> Csingle nucleotide variantrisk factorrs11196205GRCh37Chr 10, 114807047: 114807047
28NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
29KCNJ11NM_000525.3(KCNJ11): c.67A> G (p.Lys23Glu)single nucleotide variantdrug response, risk factorrs5219GRCh37Chr 11, 17409572: 17409572
30ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
31ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
32HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Insulin Resistance

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Expression patterns in normal tissues for genes affiliated with Insulin Resistance

Search GEO for disease gene expression data for Insulin Resistance.

Pathways for genes affiliated with Insulin Resistance

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Pathways related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.7PPP1R3A, INSR, IRS1, IL6, AKT2, MAPK8IP1
2
Show member pathways
10.7HNF1B, ABCC8, INSR, NEUROD1, IRS1, HNF4A
310.7IRS1, NEUROD1, SLC2A4, INSR, PTPN1, HNF4A
4
Show member pathways
10.7AKT2, NEUROD1, PAX4, SLC2A4, HNF4A, SLC2A2
5
Show member pathways
10.7INSR, IRS1, TCF7L2, IL6, MAPK8IP1, HNF4A
6
Show member pathways
10.6HNF4A, SLC2A2, SLC2A4, IL6, AKT2, TCF7L2
710.6PPP1R3A, INSR, PTPN1, IRS1, AKT2, SLC2A4
8
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.6PTPN1, IRS1, AKT2, SLC2A4, PPP1R3A, INSR
9
Show member pathways
10.6PAX4, NEUROD1, AKT2, HNF1B, HNF4A, SLC2A2
10
Show member pathways
10.6INSR, PTPN1, PPP1R3A, AKT2, IL6, GCGR
11
Show member pathways
10.6INSR, IRS1, IL6, MAPK8IP1, SLC2A4, AKT2
12
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
10.6RETN, INSR, SLC2A4, IRS1, AKT2, IL6
1310.6SLC2A4, AKT2, IRS1, PTPN1, ABCC8
14
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.6INSR, IRS1, SLC2A4, AKT2, IL6
15
Show member pathways
10.6SLC2A4, INSR, IRS1, AKT2, IL6
16
Show member pathways
Insulin Pathway37
10.6AKT2, INSR, PTPN1, IRS1
17
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
10.6PTPN1, AKT2, IRS1, SLC2A2
18
Show member pathways
10.6INSR, IRS1, AKT2, SLC2A4
19
Show member pathways
10.6INSR, AKT2, IL6, IRS1
2010.6IRS1, INSR, IL6, AKT2
21
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
10.6IRS1, AKT2, INSR, TCF7L2
2210.6INSR, HNF4A, SLC2A4, AKT2
23
Show member pathways
10.6NEUROD1, SLC2A2, HNF4A, INSR
24
Show member pathways
10.6SLC2A4, PPP1R3A, IRS1, INSR
2510.6PPP1R3A, SLC2A4, AKT2, INSR
26
Show member pathways
10.6PPP1R3A, IRS1, INSR, IL6
2710.6SLC2A4, IL6, RETN, IRS1
2810.6INSR, PTPN1, IRS1
29
Show member pathways
10.6AKT2, INSR, IRS1
30
Show member pathways
10.6AKT2, PPP1R3A, INSR
3110.6SLC2A4, AKT2, IRS1
3210.6INSR, TCF7L2, PTPN1
33
Show member pathways
10.6GCGR, SLC2A2, ABCC8
34
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
10.6PTPN1, AKT2, IL6
35
Show member pathways
10.6CAPN10, AKT2, INSR
36
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.6IRS1, IL6, AKT2
3710.6ABCC8, HNF4A, SLC2A2
3810.6IL6, AKT2, INSR
39
Show member pathways
Signal transduction PTEN pathway60
10.6AKT2, IRS1, TCF7L2
4010.6HNF4A, SLC2A4, SLC2A2
41
Show member pathways
10.6HNF4A, AKT2, TCF7L2
42
Show member pathways
Development A2B receptor action via G protein alpha s60
10.5IL6, TCF7L2, AKT2
4310.5PTPN1, IRS1
4410.5PTPN1, IRS1

Compounds for genes affiliated with Insulin Resistance

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Compounds related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1glucose4411.4RETN, IL6, MAPK8IP1, CAPN10, HNF1B, GCGR
2glycogen44 2412.3IRS1, ABCC8, AKT2, LIPC, INSR, PTPN1
3lipid4411.2HNF4A, CAPN10, RETN, AKT2, TCF7L2, IRS1
4testosterone44 61 24 1114.2HNF4A, INSR, ABCC8, PTPN1, LIPC, IRS1
5arginine4411.1HNF4A, SLC2A2, CAPN10, IRS1, LIPC, PTPN1
6tyrosine4411.1HNF4A, IL6, RETN, IRS1, SLC2A4, LIPC
7pioglitazone28 44 50 1114.1LIPC, SLC2A4, IL6, RETN, INSR, PTPN1
8sterol4411.1LIPC, PTPN1, SLC2A2, SLC2A4, HNF4A, RETN
9phosphatidylinositol4411.1INSR, TCF7L2, SLC2A4, HNF4A, RETN, AKT2
10threonine4411.1INSR, SLC2A4, LIPC, IRS1, AKT2, MAPK8IP1
11cholesterol44 28 24 1114.1ABCC8, LIPC, HNF4A, PTPN1, HNF1B, CAPN10
12metformin44 50 1113.1ABCC8, INSR, PTPN1, RETN, SLC2A4, IRS1
13serine4411.1IRS1, LIPC, PTPN1, AKT2, ABCC8, MAPK8IP1
14ly2940024411.1IL6, IRS1, RETN, AKT2, TCF7L2, INSR
15c-peptide4411.1SLC2A2, HNF4A, INSR, LIPC, IRS1, RETN
16estrogen4411.1RETN, HNF4A, AKT2, LIPC, IL6, INSR
17rosiglitazone28 44 50 24 1115.1SLC2A4, IL6, RETN, PTPN1, IRS1, INSR
18calcium44 50 24 1114.1NEUROD1, CAPN10, MAPK8IP1, RETN, LIPC, PTPN1
19fatty acid4411.1RETN, IRS1, HNF4A, LIPC, ABCC8, SLC2A4
202-deoxyglucose44 1112.0SLC2A4, IRS1, SLC2A2, PPP1R3A, INSR
21vanadium4411.0SLC2A4, IRS1, PTPN1, INSR
22repaglinide50 44 1113.0ABCC8, TCF7L2, PAX4, NEUROD1
23sulfonylurea4411.0SLC2A2, SLC2A4, ABCC8, IRS1
24glimepiride44 50 1113.0INSR, RETN, SLC2A4, ABCC8
25alanine4411.0SLC2A4, IL6, HNF4A, RETN, IRS1, INSR
26streptozotocin4411.0IRS1, SLC2A4, SLC2A2, INSR
27nitric oxide44 24 1113.0SLC2A4, TCF7L2, RETN, IL6, MAPK8IP1, PTPN1
28glycerol44 24 1113.0HNF4A, INSR, LIPC, SLC2A4, IRS1
29fructose44 1112.0PTPN1, SLC2A2, GCGR, SLC2A4
303-o-methylglucose4410.9SLC2A4, INSR, SLC2A2
31pyruvate4410.9SLC2A2, GPD2, PTPN1, HNF4A, SLC2A4
32fenofibrate44 50 1112.9IL6, RETN, LIPC, INSR
33phosphoenolpyruvate44 1111.9SLC2A2, HNF4A, SLC2A4, IRS1
34glibenclamide44 28 50 6113.9LIPC, ABCC8, INSR, SLC2A4
35atp44 2811.9LIPC, MAPK8IP1, ABCC8, HNF4A, GCGR, PTPN1
36phosphotyrosine4410.9SLC2A4, INSR, PTPN1, IRS1, MAPK8IP1
37anisomycin44 1111.9INSR, IRS1, IL6, SLC2A4
38h2o24410.9IRS1, GPD2, PTPN1, SLC2A4, SLC2A2, INSR
39sb 20358044 6111.9SLC2A4, AKT2, IL6, IRS1, INSR
40gliclazide44 50 1112.8ABCC8, INSR, SLC2A4
41palmitate4410.8HNF4A, INSR, IRS1, SLC2A4
42pd 98,0594410.8INSR, SLC2A4, HNF4A, IL6, IRS1
43oligonucleotide4410.8SLC2A2, GCGR, PTPN1, AKT2, HNF1B, HNF4A
44troglitazone44 28 61 1113.8IL6, IRS1, INSR, SLC2A4
45actinomycin d4410.7SLC2A4, INSR, IRS1, RETN, IL6
46ibmx44 61 2812.7INSR, SLC2A2, SLC2A4, IRS1
47dexamethasone44 50 28 1113.6INSR, HNF4A, IRS1, IL6, RETN, SLC2A4
48phenylarsine oxide4410.6SLC2A4, IRS1, INSR
49thiazolidinedione4410.5IRS1, RETN, SLC2A4
50sodium orthovanadate44 6111.3IRS1, PTPN1, INSR

GO Terms for genes affiliated with Insulin Resistance

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Cellular components related to Insulin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.7ABCC8, INSR, PTPN1, IRS1, AKT2, CAPN10
2insulin receptor complexGO:00589910.2INSR, IRS1

Biological processes related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1glucose homeostasisGO:04259311.0SLC2A4, INSR, NEUROD1, IRS1, TCF7L2, HNF4A
2endocrine pancreas developmentGO:03101811.0PAX4, NEUROD1, IL6, HNF1B, HNF4A, SLC2A2
3cellular response to insulin stimulusGO:03286911.0INSR, IRS1, AKT2, CAPN10, SLC2A4
4positive regulation of glucose importGO:04632610.9INSR, IRS1, AKT2, CAPN10
5response to glucoseGO:00974910.9NEUROD1, TCF7L2, HNF1B, HNF4A
6insulin receptor signaling pathwayGO:00828610.9INSR, PTPN1, IRS1, AKT2
7regulation of insulin secretionGO:05079610.9ABCC8, NEUROD1, HNF4A, SLC2A2
8positive regulation of glycogen biosynthetic processGO:04572510.9AKT2, IRS1, INSR
9response to insulinGO:03286810.9IL6, RETN, IRS1
10fat cell differentiationGO:04544410.9TCF7L2, AKT2, RETN
11positive regulation of type B pancreatic cell apoptotic processGO:200067610.9CAPN10, IL6
12positive regulation of glucose import in response to insulin stimulusGO:200127510.8IRS1, AKT2
13negative regulation of type B pancreatic cell apoptotic processGO:200067510.8NEUROD1, TCF7L2
14regulation of cell cycle arrestGO:07115610.8NEUROD1, AKT2
15positive regulation of glucose metabolic processGO:01090710.8AKT2, IRS1
16positive regulation of protein kinase B signalingGO:05189710.8INSR, TCF7L2, IL6
17carbohydrate metabolic processGO:00597510.8ABCC8, INSR, SLC2A4, SLC2A2
18energy reserve metabolic processGO:00611210.8SLC2A2, GCGR, ABCC8
19positive regulation of fatty acid beta-oxidationGO:03200010.8AKT2, IRS1
20positive regulation of transcription from RNA polymerase II promoterGO:04594410.8NEUROD1, TCF7L2, IL6, HNF1B, HNF4A
21embryonic digestive tract morphogenesisGO:04855710.7HNF1B, TCF7L2
22triglyceride homeostasisGO:07032810.6HNF4A, LIPC
23signal transduction involved in regulation of gene expressionGO:02301910.6HNF4A, NEUROD1
24negative regulation of insulin receptor signaling pathwayGO:04662710.5PTPN1, IRS1
25positive regulation of cell differentiationGO:04559710.5NEUROD1, PAX4
26JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.4IRS1, PTPN1
27positive regulation of transcription, DNA-templatedGO:04589310.3HNF4A, HNF1B, IL6, NEUROD1

Molecular functions related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9INSR, PTPN1, NEUROD1, IRS1, TCF7L2, AKT2
2sequence-specific DNA bindingGO:04356510.8HNF4A, HNF1B, TCF7L2, NEUROD1, PAX4
3D-glucose transmembrane transporter activityGO:05505610.7SLC2A4, SLC2A2
4insulin-like growth factor receptor bindingGO:00515910.6INSR, IRS1
5phosphatidylinositol 3-kinase bindingGO:04354810.5INSR, IRS1
6insulin receptor bindingGO:00515810.5PTPN1, IRS1
7transcription regulatory region DNA bindingGO:04421210.5TCF7L2, HNF1B, HNF4A
8sequence-specific DNA binding transcription factor activityGO:00370010.3HNF1B, TCF7L2, NEUROD1, PAX4, HNF4A

Products for genes affiliated with Insulin Resistance

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  • Antibodies
  • Proteins
  • Lysates

Sources for Insulin Resistance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet