MCID: INS005
MIFTS: 48

Insulin Resistance malady

Summaries for Insulin Resistance

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal... more...

MalaCards: Insulin Resistance is related to obesity and diabetes mellitus. An important gene associated with Insulin Resistance is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Translation Insulin regulation of translation and Insulin Signaling. The compounds lipid and serine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Description from OMIM:46 125853

Aliases & Classifications for Insulin Resistance

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46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

insulin resistance 46 44 60


Related Diseases for Insulin Resistance

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17GeneCards, 18GeneDecks
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Diseases in the Insulin Resistance family:

Insulin-Resistance Type B

Diseases related to Insulin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 307)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.1ENPP1, PTPN1, PTPRF, SLC2A4, INSR, IGF1
2diabetes mellitus31.7ENPP1, PTPN1, SLC2A4, INSR, IGF1, AKT2
3hypertension31.7INSR, IGF1, HSD11B1
4polycystic ovary syndrome31.7INSR, IGF1, IGF1R, IRS1
5hepatitis31.6HNF4A
6atherosclerosis31.5HSD11B1, HNF4A, TNF, IRS1, FABP2, IGF1
7type 2 diabetes mellitus31.4SLC2A4, INSR, MAPK8IP1, AKT2, PPP1R3A, IRS1
8acanthosis nigricans31.4INSR, IGF1, IGF1R, AGPAT2, BSCL2
9fatty liver disease31.3INSR, FABP2, HNF4A
10glucose intolerance31.3HSD11B1, IGF1, INSR, SLC2A4, ENPP1
11essential hypertension31.3INSR, PTPN1
12hepatitis c31.2PIK3R1, IRS1
13hyperandrogenism31.2INSR, IGF1, IGF1R
14lipodystrophy31.2HSD11B1, INSR, AGPAT2, AKT2, BSCL2
15hyperglycemia31.2IRS1, HNF1B, HNF4A, HSD11B1, IGF1R, IGF1
16gestational diabetes31.1HNF4A, IRS1, INSR, SLC2A4, ENPP1
17acromegaly30.8IGF1, HSD11B1
18hyperinsulinism30.7IRS1, IGF1, INSR
19breast cancer30.7AKT2, PIK3R1, IRS1, HNF4A, IGF1R, IGF1
20metabolic syndrome x30.7HSD11B1, HNF4A, INSR, PTPN1
21myocardial infarction30.6ENPP1
22schizophrenia30.6INSR
23hypoglycemia30.6HNF4A, IGF1, INSR, SLC2A4
24uremia30.6ENPP1, INSR, IGF1
25alzheimer's disease30.5PIK3R1, MAPK8IP1, INSR, PTPN1
26liver cirrhosis30.5SLC2A4, INSR, IRS1, HNF4A
27diabetic retinopathy30.5INSR, IGF1
28hyperthyroidism30.5INSR, IGF1
29hypogonadism30.4IGF1
30werner syndrome30.4INSR
31pancreatic cancer30.4HNF4A, IRS1, PIK3R1, AKT2, IGF1R, IGF1
32adenoma30.4HSD11B1, HNF4A, IGF1R, IGF1, INSR
33insulinoma30.4INSR, HNF4A
34familial partial lipodystrophy30.4BSCL2, AGPAT2
35hyperuricemia30.4FABP2, HNF1B
36gout30.4HNF1B
37prostate cancer30.3HNF4A, HNF1B, IRS1, PIK3R1, AKT2, IGF1R
38leukemia30.3TNF, IRS1, PPP1R3A, PIK3R1, PTPN1
39myopathy30.3SLC2A4, IGF1
40colorectal cancer30.2HNF4A, IRS1, PPP1R3A, IGF1R, IGF1, INSR
41colon cancer30.2HNF4A, IRS1, PIK3R1, IGF1R, IGF1
42ischemia30.2FABP2, MAPK8IP1, INSR, SLC2A4
43rabson-mendenhall syndrome30.2INSR, IGF1
44turner syndrome30.2IGF1
45adenocarcinoma30.1HSD11B1, HNF4A, HNF1B, PIK3R1, AKT2, IGF1R
46congenital generalized lipodystrophy type 230.1BSCL2, AGPAT2, INSR
47maturity-onset diabetes of the young30.1HNF4A, HNF1B
48hepatocellular carcinoma29.9HNF4A, HNF1B, IRS1, PIK3R1, IGF1R, INSR
49liver disease10.9
50coronary artery disease10.8

Graphical network of the top 20 diseases related to Insulin Resistance:



Diseases related to insulin resistance

Clinical Features for Insulin Resistance

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46OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Insulin Resistance

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Insulin Resistance

Drug clinical trials:

Search ClinicalTrials for Insulin Resistance

Search NIH Clinical Center for Insulin Resistance

Search CenterWatch for Insulin Resistance

Genetic Tests for Insulin Resistance

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Anatomical Context for Insulin Resistance

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32MalaCards
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MalaCards organs/tissues related to Insulin Resistance:

32
Pancreas

Animal Models for Insulin Resistance or affiliated genes

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36MGI
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Publications for Insulin Resistance

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Genetic Variations for Insulin Resistance

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Insulin Resistance:

62 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Expression for genes affiliated with Insulin Resistance

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Insulin Resistance

Search GEO for disease gene expression data for Insulin Resistance.

Pathways for genes affiliated with Insulin Resistance

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 49PharmGKB, 52R&D Systems, 53Reactome, 59Tocris Bioscience
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Pathways related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Translation Insulin regulation of translation
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12.3TNF, PTPRF, IRS1, PPP1R3A, PIK3R1, SLC2A4
212.1PIK3R1, PTPN1, ENPP1, PTPRF, SLC2A4, INSR
3
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12.1TNF, HNF4A, PPP1R3A, PIK3R1, IRS1, INSR
4
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11.9SLC2A4, INSR, MAPK8IP1, IGF1, IGF1R, PIK3R1
5
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11.9AKT2, INSR, IRS1, TNF, HNF4A, IGF1R
6
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11.9HNF4A, TNF, PIK3R1, AKT2, PTPN1, PTPRF
711.8IGF1R, HNF4A, IRS1, AKT2, INSR, PTPN1
8
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11.6INSR, HNF1B, TNF, IRS1, SLC2A4, PIK3R1
9
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11.6PTPN1, PPP1R3A, PIK3R1, IGF1, INSR, IGF1R
10
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11.6SLC2A4, INSR, IGF1, PIK3R1, IRS1, AKT2
11
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11.6IGF1, INSR, PIK3R1, IGF1R, PPP1R3A, TNF
12
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11.6SLC2A4, PIK3R1, IRS1, IGF1, TNF, AKT2
13
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11.4SLC2A4, TNF, IRS1, PIK3R1, INSR, AKT2
14
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11.4IGF1R, INSR, IGF1, IRS1, PIK3R1, PPP1R3A
1511.4IRS1, INSR, IGF1, IGF1R, AKT2, PIK3R1
16
Development Ligand-independent activation of ESR1 and ESR2
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11.4AKT2, IRS1, PIK3R1, IGF1R, IGF1, INSR
17
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11.4IGF1, INSR, IGF1R, AKT2, PIK3R1, IRS1
18
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11.4INSR, IGF1R, PPP1R3A, PIK3R1, AKT2, IGF1
1911.3PTPN1, INSR, AKT2, PIK3R1, IRS1
20
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11.3PIK3R1, INSR, SLC2A4, PPP1R3A, IRS1
21
Development Leptin signaling via PI3K-dependent pathway
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11.3AKT2, PTPN1, PIK3R1, SLC2A4, IRS1
2211.3IRS1, INSR, PIK3R1, SLC2A4, AKT2
2311.3PIK3R1, AKT2, INSR, HNF4A, SLC2A4
24
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11.3INSR, IGF1R, PPP1R3A, AKT2, PIK3R1
25
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11.3PIK3R1, IRS1, IGF1R, IGF1, INSR
26
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11.3IRS1, PIK3R1, AKT2, IGF1R, IGF1
27
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11.3PIK3R1, IRS1, AKT2, IGF1, IGF1R
28
Development Dopamine D2 receptor transactivation of EGFR
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11.3IRS1, PIK3R1, AKT2, IGF1, IGF1R
29
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11.3IGF1, AKT2, PIK3R1, IRS1, IGF1R
30
Transcription Androgen Receptor nuclear signaling
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11.3IRS1, AKT2, PIK3R1, IGF1R, IGF1
31
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11.3AKT2, IGF1R, IGF1, IRS1, PIK3R1
3211.3IGF1, BSCL2, IRS1, SLC2A4, AGPAT2
3311.3INSR, IGF1R, AKT2, IGF1, PIK3R1
34
Apoptosis and survival Caspase cascade
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11.3IGF1R, IGF1, TNF, IRS1, AKT2
3511.3AKT2, PIK3R1, IGF1R, IGF1, TNF
3611.1PPP1R3A, AKT2, INSR, SLC2A4
3711.1INSR, PTPN1, PIK3R1, IRS1
38
Development Prolactin receptor signaling
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11.1PTPN1, AKT2, IRS1, PIK3R1
3911.1AKT2, IRS1, SLC2A4, TNF
4011.1PTPN1, IGF1R, PTPRF, INSR
4111.1INSR, PIK3R1, IGF1, IRS1
4211.1IGF1R, IRS1, PTPN1, PIK3R1
43
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11.1PIK3R1, AKT2, IGF1R, INSR
4411.1IGF1R, AKT2, INSR, PIK3R1
4511.1AKT2, PIK3R1, IGF1, IGF1R
46
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11.1IGF1, IGF1R, AKT2, PIK3R1
47
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11.1TNF, PIK3R1, IGF1R, IGF1
4811.0PIK3R1, INSR, PTPN1
49
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11.0HNF4A, AKT2, HNF1B
5011.0PIK3R1, AKT2, TNF

Compounds for genes affiliated with Insulin Resistance

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1lipid4413.0PTPN1, IRS1, TNF, HSD11B1, PPP1R3A, ENPP1
2serine4413.0PIK3R1, HNF4A, TNF, IRS1, ENPP1, PTPN1
3glycogen44 2413.9HNF4A, INSR, IGF1R, HSD11B1, AKT2, ENPP1
4threonine4412.9PIK3R1, FABP2, IRS1, AKT2, IGF1R, MAPK8IP1
5tyrosine4412.8INSR, ENPP1, PTPN1, PTPRF, IGF1, IGF1R
6glucose4412.7MAPK8IP1, IGF1R, PPP1R3A, HNF1B, HNF4A, IGF1
7phosphatidylinositol4412.5IGF1, AKT2, IGF1R, PTPN1, HNF4A, INSR
8testosterone44 59 11 2415.3HNF4A, PTPN1, IGF1R, INSR, IRS1, PIK3R1
9phosphotyrosine4412.2PTPN1, PTPRF, SLC2A4, IGF1R, IRS1, PIK3R1
10dexamethasone44 49 28 1115.2INSR, IRS1, PIK3R1, HSD11B1, IGF1R, ENPP1
11rapamycin4412.2IGF1, IGF1R, AKT2, IRS1, INSR, SLC2A4
12pd 98,0594412.2TNF, HNF4A, SLC2A4, IRS1, PIK3R1, IGF1R
13ly2940024412.2PIK3R1, TNF, IGF1, INSR, SLC2A4, IRS1
14h2o24412.1IGF1R, PTPRF, PIK3R1, IRS1, TNF, SLC2A4
15cholesterol44 28 11 2415.1PIK3R1, FABP2, PTPN1, IGF1, IGF1R, HNF1B
162-deoxyglucose44 1113.1IGF1, SLC2A4, IGF1R, INSR, PPP1R3A, IRS1
17alanine4412.0PTPN1, HNF4A, HSD11B1, FABP2, IGF1R, INSR
18sb 20358044 5913.0TNF, INSR, IRS1, PIK3R1, AKT2, IGF1
19wortmannin4412.0SLC2A4, IGF1R, AKT2, PIK3R1, IRS1, INSR
20genistein44 28 59 2 11 2417.0INSR, TNF, IGF1, IRS1, PIK3R1, IGF1R
21glutamine4411.9IGF1R, IGF1, INSR, PTPN1, ENPP1, HNF4A
22retinoic acid44 2412.9HNF4A, FABP2, SLC2A4, IGF1, TNF, IRS1
23thymidine44 2412.9TNF, INSR, IGF1, IGF1R, HNF4A, IRS1
24metformin44 49 1113.9SLC2A4, PTPN1, INSR, IGF1, IRS1, ENPP1
25pioglitazone44 49 28 1114.9HSD11B1, SLC2A4, TNF, INSR, PTPN1, IRS1
26rosiglitazone44 49 28 11 2415.8INSR, SLC2A4, PTPN1, HSD11B1, IRS1, TNF
27sterol4411.8PTPN1, PIK3R1, IRS1, HNF4A, HSD11B1, SLC2A4
28okadaic acid44 5912.8IGF1R, PTPN1, SLC2A4, PIK3R1, IRS1, HNF4A
29phenylalanine4411.8INSR, IRS1, FABP2, PIK3R1, PTPN1, IGF1R
30c-peptide4411.7HNF4A, IRS1, IGF1R, IGF1, INSR
31actinomycin d4411.7TNF, IGF1R, INSR, IRS1, SLC2A4, IGF1
32arginine4411.6PTPN1, INSR, IGF1, IGF1R, HNF1B, HNF4A
33ibmx44 28 5913.5IGF1R, IGF1, IRS1, SLC2A4, INSR
34vanadium4411.5INSR, SLC2A4, IRS1, PTPN1
35ag 10244411.5IGF1R, IRS1, IGF1, INSR
36palmitate4411.4SLC2A4, HNF4A, FABP2, IRS1
37glycerol44 11 2413.4HSD11B1, HNF4A, IRS1, SLC2A4, INSR
38glucosamine44 11 2413.4SLC2A4, INSR, TNF, IRS1
39fatty acid4411.3SLC2A4, ENPP1, HSD11B1, FABP2, IRS1, HNF4A
40picropodophyllotoxin5911.3IGF1R, IGF1, INSR
41insulin (human) recombinant5911.3INSR, IGF1R, IGF1
42phosphoserine44 2412.3PTPN1, IRS1, INSR, IGF1R
43bms 5369245911.3IGF1, INSR, IGF1R
44demethylasterriquinone b15911.3IGF1R, IGF1, INSR
45phosphoenolpyruvate44 1112.3HSD11B1, HNF4A, IRS1, SLC2A4
46mecasermin44 1112.3IGF1, IGF1R, INSR
47c2ceramide4411.2IRS1, TNF, PIK3R1, SLC2A4
48estrogen4411.0HSD11B1
492,4-dinitrophenol4411.0IRS1, IGF1, SLC2A4
50anisomycin44 1111.7INSR, SLC2A4, IRS1

GO Terms for genes affiliated with Insulin Resistance

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16Gene Ontology
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Cellular components related to Insulin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.0TNF, IRS1, FABP2, PIK3R1, AKT2, IGF1R
2caveolaGO:00590111.0INSR, IGF1R, IRS1
3insulin receptor complexGO:00589910.7INSR, IRS1

Biological processes related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1insulin receptor signaling pathwayGO:00828611.8IRS1, PIK3R1, AKT2, IGF1R, INSR, PTPN1
2positive regulation of glucose importGO:04632611.7INSR, IGF1, AKT2, PIK3R1, IRS1
3cellular response to insulin stimulusGO:03286911.6IRS1, AKT2, INSR, SLC2A4, ENPP1
4insulin-like growth factor receptor signaling pathwayGO:04800911.5IRS1, PIK3R1, IGF1R, IGF1
5positive regulation of glycogen biosynthetic processGO:04572511.5IRS1, AKT2, IGF1, INSR
6positive regulation of protein kinase B signaling cascadeGO:05189711.5TNF, IGF1R, IGF1, INSR
7glucose homeostasisGO:04259311.5HNF4A, IRS1, INSR, SLC2A4
8positive regulation of cell migrationGO:03033511.4IRS1, PIK3R1, IGF1R, INSR
9phosphatidylinositol-mediated signalingGO:04801511.4IGF1, IGF1R, PIK3R1, IRS1
10exocrine pancreas developmentGO:03101711.3IGF1R, IGF1, INSR
11regulation of JNK cascadeGO:04632811.3MAPK8IP1, IGF1R, AKT2
12mammary gland developmentGO:03087911.3IGF1, IGF1R, IRS1
13phosphatidylinositol 3-kinase cascadeGO:01406511.3IRS1, PIK3R1, IGF1R
14negative regulation of insulin receptor signaling pathwayGO:04662711.3ENPP1, PTPN1, IRS1
15positive regulation of mitosisGO:04584011.3INSR, IGF1, TNF
16positive regulation of DNA replicationGO:04574011.2INSR, IGF1, IGF1R
17positive regulation of MAPK cascadeGO:04341011.1INSR, IGF1, IGF1R
18sequestering of triglycerideGO:03073011.1TNF, ENPP1
19positive regulation of glucose import in response to insulin stimulusGO:200127511.0IRS1, AKT2
20positive regulation of glucose metabolic processGO:01090711.0AKT2, IRS1
21negative regulation of glucose importGO:04632510.9TNF, ENPP1
22lipid particle organizationGO:03438910.9BSCL2, CIDEC
23positive regulation of fatty acid beta-oxidationGO:03200010.9IRS1, AKT2
24positive regulation of glycolysisGO:04582110.8IGF1, INSR
25negative regulation of lipid catabolic processGO:05099510.8BSCL2, TNF
26male sex determinationGO:03023810.7IGF1R, INSR
27positive regulation of protein phosphorylationGO:00193410.7INSR, AKT2, TNF

Molecular functions related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.5HNF4A, HNF1B, TNF, IRS1, PIK3R1, AKT2
2insulin receptor bindingGO:00515811.6ENPP1, PTPN1, IGF1, IGF1R, PIK3R1, IRS1
3insulin-like growth factor receptor bindingGO:00515911.3IRS1, PIK3R1, IGF1, INSR
4phosphatidylinositol 3-kinase bindingGO:04354811.2IRS1, PIK3R1, IGF1R, INSR
5insulin bindingGO:04355911.0INSR, IGF1R, PIK3R1
6insulin receptor substrate bindingGO:04356011.0PIK3R1, IGF1R, INSR
7transmembrane receptor protein tyrosine kinase adaptor activityGO:00506810.8PIK3R1, IRS1
8insulin-like growth factor I bindingGO:03199410.5INSR, IGF1R

Products for genes affiliated with Insulin Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Insulin Resistance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet