MCID: INS005
MIFTS: 66

Insulin Resistance malady

Genetic diseases, Rare diseases, Endocrine diseases categories
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Summaries for Insulin Resistance

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65Wikipedia, 47OMIM, 33MalaCards
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Fully expand this MalaCard
Wikipedia:65 Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal... more...

MalaCards: Insulin Resistance is related to obesity and polycystic ovary syndrome. An important gene associated with Insulin Resistance is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Insulin-mediated glucose transport and Signaling events mediated by PTP1B. The compounds vanadium and ag 1024 have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and skeletal muscle, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Description from OMIM:47 125853

Aliases & Classifications for Insulin Resistance

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47OMIM, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

insulin resistance 47 45 62


Related Diseases for Insulin Resistance

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17GeneCards, 18GeneDecks
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Diseases in the Insulin Resistance family:

Insulin-Resistance Type B

Diseases related to Insulin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.2IRS1, SORBS1, PTPRF, PTPN1, HSD11B1, TNF
2polycystic ovary syndrome31.9IGF1, IGF1R, INSR, IRS1
3hypertension31.8HSD11B1, INSR, IGF1
4diabetes mellitus31.7FABP2, IRS1, PTPN1, HSD11B1, TNF, INSR
5atherosclerosis31.7IGF1, TNF, HSD11B1, PTPN1, IRS1, FABP2
6acanthosis nigricans31.7BSCL2, IGF1, IGF1R, INSR, AGPAT2
7glucose intolerance31.6IGF1, INSR, HSD11B1, ENPP1, SLC2A4
8fatty liver disease31.5HNF4A, FABP2, INSR
9hyperandrogenism31.5IGF1, IGF1R, INSR
10lipodystrophy31.4AGPAT2, AKT2, HSD11B1, INSR, BSCL2
11type 2 diabetes mellitus31.4SLC2A4, HNF4A, HNF1B, MAPK8IP1, AKT2, IRS1
12hypertriglyceridemia31.3BSCL2, INSR, IRS1, FABP2, SLC2A4
13hyperglycemia31.3IGF1, IGF1R, INSR, HSD11B1, IRS1, HNF1B
14gestational diabetes31.3INSR, IRS1, HNF4A, ENPP1, SLC2A4
15hyperinsulinism31.0IGF1, INSR, IRS1
16uremia30.9IGF1, INSR, ENPP1
17metabolic syndrome x30.8SLC2A4, HSD11B1
18rabson-mendenhall syndrome30.8IGF1, INSR
19breast cancer30.8PIK3R1, IGF1, IGF1R, INSR, PTPN1, PTPRF
20hypoglycemia30.8IGF1, INSR, HNF4A, SLC2A4
21type 1 diabetes mellitus30.8IGF1, INSR, HNF4A, ENPP1
22alzheimer's disease30.7MAPK8IP1, PTPN1, INSR, PIK3R1
23liver cirrhosis30.7SLC2A4, IRS1, INSR
24familial partial lipodystrophy30.7AGPAT2, BSCL2
25pancreatic cancer30.5PIK3R1, IGF1, IGF1R, IRS1, AKT2, HNF4A
26adenoma30.5IGF1, IGF1R, INSR, HSD11B1, HNF4A
27sepsis30.5INSR, TNF, IRS1, SLC2A4
28colorectal cancer30.4PPP1R3A, IGF1, IGF1R, INSR, IRS1, HNF4A
29ischemia30.4INSR, FABP2, MAPK8IP1, SLC2A4
30congenital generalized lipodystrophy type 230.4BSCL2, INSR, AGPAT2
31prostate cancer30.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
32maturity-onset diabetes of the young30.2HNF4A, HNF1B
33adenocarcinoma30.2PIK3R1, IGF1R, INSR, HSD11B1, AKT2, HNF1B
34colon cancer30.1HNF4A, IRS1, IGF1R, PIK3R1
35hepatocellular carcinoma30.0PIK3R1, IGF1R, INSR, IRS1, HNF1B, HNF4A
36hepatitis11.1
37liver disease11.0
38endotheliitis10.9
39essential hypertension10.9
40hepatitis c10.9
41artery disease10.8
42coronary artery disease10.8
43kidney disease10.7
44hepatitis c virus10.6
45pancreatitis10.6
46nonalcoholic steatohepatitis10.6
47morbid obesity10.6
48familial combined hyperlipidemia10.6
49arthritis10.6
50acromegaly10.5

Graphical network of the top 20 diseases related to Insulin Resistance:



Diseases related to insulin resistance

Symptoms for Insulin Resistance

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47OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Insulin Resistance

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Insulin Resistance

Search NIH Clinical Center for Insulin Resistance

Genetic Tests for Insulin Resistance

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Anatomical Context for Insulin Resistance

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33MalaCards
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MalaCards organs/tissues related to Insulin Resistance:

33
Ovary, Liver, Skeletal muscle, Adipocyte, Heart, Endothelial, Kidney, Pancreas, Testes, Monocytes, Bone, Thyroid, Breast, Brain, Skin, Prostate, Colon, B cells, Smooth muscle, Pituitary, Lung, T cells, Small intestine, Myeloid, Amygdala, Salivary gland, Pancreatic islet, Hypothalamus, Cortex, Retina, Eye, Placenta, Spinal cord

Animal Models for Insulin Resistance or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Insulin Resistance:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.5PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, TNF
2MP:000537910.5IGF1, INSR, TNF, HSD11B1, PTPN1, PTPRF
3MP:000536710.4BSCL2, IGF1, INSR, PTPRF, FABP2, HNF1B
4MP:000539010.4IGF1, IGF1R, TNF, PTPN1, PTPRF, IRS1
5MP:000538510.4IGF1R, IGF1, BSCL2, PIK3R1, INSR, TNF
6MP:000537010.4PIK3R1, BSCL2, IGF1R, INSR, TNF, HSD11B1
7MP:000539710.4PIK3R1, BSCL2, IGF1, IGF1R, INSR, TNF
8MP:000538410.4INSR, IGF1R, IGF1, BSCL2, PIK3R1, TNF
9MP:000537510.4IGF1, IGF1R, INSR, TNF, HSD11B1, PTPN1
10MP:000538710.3TNF, INSR, IGF1R, IGF1, BSCL2, PIK3R1
11MP:000363110.3IGF1, IGF1R, INSR, TNF, HSD11B1, PTPRF
12MP:001077110.3BSCL2, IGF1, IGF1R, TNF, PTPRF, AKT2
13MP:000537810.3PPP1R3A, PIK3R1, BSCL2, IGF1, IGF1R, INSR
14MP:000538610.3TNF, INSR, IGF1R, BSCL2, HSD11B1, PTPN1
15MP:001076810.3PTPN1, TNF, INSR, IGF1R, IGF1, BSCL2
16MP:000538110.3BSCL2, IGF1R, INSR, TNF, PTPRF, SLC2A4
17MP:000200610.3AKT2, TNF, IGF1R, IGF1, PIK3R1
18MP:000537610.3AGPAT2, IGF1, IGF1R, INSR, TNF, HSD11B1
19MP:000538910.3BSCL2, IGF1, IGF1R, INSR, TNF, AKT2
20MP:000538810.2IGF1, IGF1R, INSR, TNF, HSD11B1, AKT2
21MP:000537110.0IGF1, IGF1R, TNF, IRS1, AGPAT2

Publications for Insulin Resistance

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52PubMed
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Articles related to Insulin Resistance:

(show top 50)    (show all 4999)
idTitleAuthorsYear
1
Accuracy and precision of commonly used methods for quantifying surgery-induced insulin resistance: Prospective observational study. (24257458)
2014
2
The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. (23649472)
2014
3
Correction: Overexpressing STAMP2 Improves Insulin Resistance in Diabetic ApoE(-/-)/LDLR(-/-) Mice via Macrophage Polarization Shift in Adipose Tissues. (24391692)
2013
4
The Severity of Menstrual Dysfunction as a Predictor of Insulin Resistance in PCOS. (24092831)
2013
5
Association between I^2-adrenoceptor (ADRB2) haplotypes and insulin resistance in PCOS. (22900502)
2013
6
Wrist breadth and homeostasis model assessment of insulin resistance in youth: the Fels Longitudinal Study. (23897560)
2013
7
Heat Shock Prevents Insulin Resistance Induced Vascular Complications By Augmenting Angiotensin-(1-7) Signalling. (24270982)
2013
8
Association between insulin resistance and sustained virologic response in hepatitis C treatment, genotypes 1 versus 2 and 3: systematic literature review and meta-analysis. (24055394)
2013
9
Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. (23560057)
2013
10
High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients. (22136974)
2012
11
Increased insulin resistance and C-reactive protein in women with complete hydatidiform mole. (21204606)
2011
12
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
13
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
14
Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. (20107300)
2010
15
Insulin resistance and overweight-obese women with polycystic ovary syndrome. (19903118)
2010
16
The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes. (19139803)
2009
17
Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases. (19146801)
2009
18
Role of mitochondrial dysfunction in insulin resistance. (18309108)
2008
19
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. (18443205)
2008
20
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
21
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
22
Resistin: a hormone which induces insulin resistance is increased in normal pregnancy. (17919114)
2007
23
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
24
Insulin resistance and atherosclerosis. (16823479)
2006
25
Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance. (16478779)
2006
26
Association of inflammatory marker and highly sensitive C-reactive protein with aerobic exercise capacity, maximum oxygen uptake and insulin resistance in healthy middle-aged volunteers. (15791041)
2005
27
Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. (16034720)
2005
28
Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. (16182246)
2005
29
Molecular mechanisms of impaired endothelial function associated with insulin resistance. (15032648)
2004
30
Should we routinely measure a proxy for insulin resistance as well as improve our modelling techniques to better predict the likelihood of coronary heart disease in people with type 2 diabetes. (15171756)
2004
31
Inflammation, insulin resistance, and adiposity: a study of first-degree relatives of type 2 diabetic subjects. (15277436)
2004
32
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
33
Unraveling the mysteries of syndrome X. As the number of Americans with insulin resistance grows, pharmacists can help patients prevent the onset of type 2 diabetes and cardiovascular disease. (14626524)
2003
34
Relationship of insulin resistance and overweight with cortisol and dehydroepiandrosterone-sulfate levels. (12505096)
2002
35
Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia. (12145148)
2002
36
Insulin-regulated transcription factors: molecular link between insulin resistance and cardiovascular risk factors. (11466584)
2001
37
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
38
Serum leptin concentrations in young insulin-sensitive and insulin-resistant volunteers. (10965933)
2000
39
Remodeling of the endocrine pancreas: the central role of amylin and insulin resistance. (10653060)
2000
40
AlstrAPm syndrome with subclinical insulin-resistant diabetes and hepatic dysfunction: a family report. (10845422)
2000
41
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine. (10574416)
1999
42
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
43
Components of the insulin resistance syndrome are associated with progression of atherosclerosis in non-grafted arteries 5 years after coronary artery bypass surgery. (9717003)
1998
44
Cellular mechanism of nutritionally induced insulin resistance: the desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome. (10212843)
1998
45
Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. (9222647)
1997
46
Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. (9056694)
1997
47
Epidemiology of hypertension and insulin resistance syndrome. (9050982)
1997
48
Insulin resistance in insulin-dependent diabetic patients with microalbuminuria. (8105164)
1993
49
Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle. (1547918)
1992
50
Association of specific histocompatibility antigens and acanthosis nigricans with insulin resistance. (2101060)
1990

Variations for Insulin Resistance

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Insulin Resistance:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Insulin Resistance:

1 (show all 16)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
3AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
4INSRNM_000208.2(INSR): c.3481G> A (p.Ala1161Thr)single nucleotide variantPathogenicrs121913139GRCh37Chr 19, 7122673: 7122673
5INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
6INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
7GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
8SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
9GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
10IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
11IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
12MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
13NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
14ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
15ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
16HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Insulin Resistance

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Insulin Resistance

Search GEO for disease gene expression data for Insulin Resistance.

Pathways for genes affiliated with Insulin Resistance

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 53QIAGEN, 54R&D Systems, 61Tocris Bioscience, 55Reactome, 12EMD Millipore, 51PharmGKB, 5Cell Signaling Technology
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Pathways related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PPP1R3A, INSR, AKT2, SLC2A4
210.4PIK3R1, INSR, PTPN1, IRS1
3
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
10.4AKT2, IRS1, PTPN1, PIK3R1
410.4TNF, IRS1, AKT2, SLC2A4
510.4IRS1, INSR, IGF1, PIK3R1
610.4IRS1, PTPN1, IGF1R, PIK3R1
710.4PIK3R1, PTPN1, IRS1, AKT2, SLC2A4
8
Show member pathways
10.4SLC2A4, IRS1, INSR, PIK3R1, PPP1R3A
9
Show member pathways
10.4PIK3R1, INSR, IRS1, AKT2, SLC2A4
1010.4AKT2, INSR, IGF1R, PIK3R1
1110.4PIK3R1, INSR, AKT2, HNF4A, SLC2A4
12
Show member pathways
10.3PIK3R1, IGF1, IGF1R, AKT2
1310.3AKT2, IGF1R, IGF1, PIK3R1
14
Show member pathways
10.3AKT2, INSR, IGF1R, PIK3R1, PPP1R3A
15
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
10.3PIK3R1, IGF1, IGF1R, TNF
16
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
10.3IGF1, IGF1R, TNF, IRS1, AKT2
17
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
18
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
19
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
20
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
21
Show member pathways
Signal transduction PTEN pathway60
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
22
Show member pathways
Signaling Pathways in Glioblastoma38
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
23
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.3AKT2, IRS1, IGF1R, IGF1, PIK3R1
24
Show member pathways
10.3PIK3R1, IGF1, IGF1R, INSR, AKT2
2510.3PIK3R1, IGF1, IGF1R, INSR, AKT2
26
Show member pathways
Insulin Pathway38
10.3PIK3R1, INSR, PTPN1, SORBS1, IRS1, AKT2
2710.3SORBS1, PTPRF, PTPN1, INSR, IGF1R
28
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, IRS1
2910.3PIK3R1, IGF1, IGF1R, TNF, AKT2
3010.3PIK3R1, IGF1, IGF1R, TNF, AKT2
3110.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
32
Show member pathways
10.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
33
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1R, INSR, TNF, SLC2A4
3410.3BSCL2, IGF1, TNF, IRS1, SLC2A4, AGPAT2
35
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, AKT2
36
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
10.3PIK3R1, IGF1, IGF1R, SORBS1, AKT2
37
Show member pathways
10.3PIK3R1, INSR, TNF, IRS1, HNF1B, HNF4A
38
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, PTPN1
3910.3IGF1R, INSR, PTPN1, IRS1, AKT2, HNF4A
40
Show member pathways
10.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
41
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
10.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
42
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
10.3PIK3R1, INSR, TNF, SORBS1, IRS1, AKT2
43
Show member pathways
10.3PIK3R1, IGF1, IGF1R, TNF, IRS1, AKT2
44
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, TNF
45
Show member pathways
10.2PIK3R1, IGF1, IGF1R, INSR, TNF, IRS1
46
Show member pathways
10.2PIK3R1, IGF1, IGF1R, INSR, TNF, IRS1
47
Show member pathways
10.2PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, TNF
4810.2ENPP1, AKT2, IRS1, SORBS1, PTPRF, PTPN1
49
Show member pathways
10.2PIK3R1, IGF1, IGF1R, TNF, PTPN1, PTPRF
50
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.1SLC2A4, PPP1R3A, AKT2, IRS1, SORBS1, PTPRF

Compounds for genes affiliated with Insulin Resistance

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1vanadium4510.8IRS1, SLC2A4, INSR, PTPN1
2ag 10244510.8IGF1, IRS1, INSR, IGF1R
3metformin45 51 1112.8ENPP1, IRS1, IGF1, INSR, SLC2A4, PTPN1
4pioglitazone29 45 51 1113.8TNF, INSR, HSD11B1, PTPN1, IRS1, SLC2A4
5rosiglitazone29 45 51 24 1114.7SLC2A4, IRS1, PTPN1, HSD11B1, TNF, INSR
62-deoxyglucose45 1111.7IRS1, IGF1, PPP1R3A, SLC2A4, PIK3R1, IGF1R
7sterol4510.7HSD11B1, PTPN1, PIK3R1, IRS1, HNF4A, SLC2A4
8c-peptide4510.7IGF1, IGF1R, INSR, IRS1, HNF4A
9bms 5369246110.7IGF1, IGF1R, INSR
10picropodophyllotoxin6110.7INSR, IGF1R, IGF1
11demethylasterriquinone b16110.7IGF1, IGF1R, INSR
12phosphotyrosine4510.7SLC2A4, MAPK8IP1, IRS1, PTPRF, PTPN1, INSR
13insulin (human) recombinant6110.7INSR, IGF1, IGF1R
14sb 20358045 6111.7SLC2A4, AKT2, IRS1, TNF, INSR, IGF1
15rapamycin4510.7SLC2A4, PIK3R1, AKT2, IGF1, INSR, IRS1
16okadaic acid45 6111.7PTPN1, PIK3R1, IRS1, HNF4A, SLC2A4, IGF1R
17wortmannin4510.7IGF1, IGF1R, PIK3R1, IRS1, INSR, AKT2
18pd 98,0594510.7HNF4A, IRS1, IGF1R, IGF1, INSR, TNF
19ly2940024510.7IRS1, INSR, IGF1, IGF1R, TNF, SLC2A4
20phenylalanine4510.7FABP2, IRS1, PTPN1, INSR, IGF1R, PIK3R1
21testosterone45 61 24 1113.7HNF4A, IRS1, SLC2A4, PTPN1, HSD11B1, INSR
22phosphatidylinositol4510.7IRS1, AKT2, PIK3R1, HNF4A, ENPP1, SLC2A4
23palmitate4510.7IRS1, FABP2, HNF4A, SLC2A4, INSR
24genistein45 29 61 3 24 1115.6IRS1, IGF1, PIK3R1, IGF1R, INSR, TNF
25h2o24510.6PIK3R1, SLC2A4, PTPRF, PTPN1, INSR, IGF1R
26mecasermin45 1111.6IGF1R, IGF1, INSR
27glutamine4510.6PTPN1, ENPP1, HNF4A, IGF1, IGF1R, INSR
28dexamethasone45 51 29 1113.6TNF, INSR, IGF1R, IGF1, PIK3R1, ENPP1
29glycogen45 2411.6PPP1R3A, IGF1R, INSR, HSD11B1, PTPN1, PIK3R1
30cholesterol45 29 24 1113.6HSD11B1, IGF1, IGF1R, PTPN1, FABP2, HNF1B
31estrogen4510.6PTPN1, HSD11B1, INSR, AKT2, IRS1, IGF1
32threonine4510.6HNF4A, ENPP1, MAPK8IP1, AKT2, PTPN1, PIK3R1
33ibmx45 61 2912.6SLC2A4, IRS1, INSR, IGF1R, IGF1
34alanine4510.6IGF1R, HSD11B1, INSR, IRS1, FABP2, HNF4A
35thymidine45 2411.6IGF1R, HNF4A, INSR, TNF, IRS1, PIK3R1
36lipid4510.6PPP1R3A, SLC2A4, AGPAT2, ENPP1, PIK3R1, INSR
37serine4510.6PIK3R1, IGF1R, INSR, TNF, SLC2A4, PTPN1
38glucosamine45 24 1112.6INSR, SLC2A4, TNF, IRS1
39tyrosine4510.6SLC2A4, ENPP1, PIK3R1, IGF1, AKT2, IRS1
40cycloheximide4510.5INSR, IGF1R, TNF, PIK3R1, IGF1, IRS1
41actinomycin d4510.5SLC2A4, IRS1, TNF, INSR, IGF1R, IGF1
42glycerol45 24 1112.5SLC2A4, HNF4A, INSR, IRS1, HSD11B1
43phosphoserine45 2411.5PTPN1, IRS1, IGF1R, INSR
44retinoic acid45 2411.5HNF4A, SLC2A4, IGF1R, TNF, IRS1, FABP2
45glucose4510.5SLC2A4, ENPP1, HNF4A, HNF1B, MAPK8IP1, AKT2
46phosphoenolpyruvate45 1111.5HNF4A, HSD11B1, IRS1, SLC2A4
47fatty acid4510.3FABP2, ENPP1, SLC2A4, HNF4A, IRS1, HSD11B1
48c2ceramide4510.3TNF, PIK3R1
49nitric oxide45 24 1112.3PTPN1, PIK3R1, IGF1R, SLC2A4, HNF4A, MAPK8IP1
50arginine4510.0IGF1, PTPN1, INSR, IRS1, HNF1B, HNF4A

GO Terms for genes affiliated with Insulin Resistance

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Sources:
16Gene Ontology
See all sources

Cellular components related to Insulin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor complexGO:00589910.4IRS1, SORBS1, INSR
2integral component of plasma membraneGO:00588710.3SLC2A4, ENPP1, PTPRF, TNF, INSR, IGF1R
3plasma membraneGO:00588610.1PIK3R1, IGF1, IGF1R, INSR, TNF, PTPN1
4caveolaGO:00590110.1IGF1R, INSR, IRS1

Biological processes related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of insulin receptor signaling pathwayGO:04662710.8PTPN1, IRS1, ENPP1
2glucose homeostasisGO:04259310.8SLC2A4, HNF4A, IRS1, INSR
3exocrine pancreas developmentGO:03101710.8INSR, IGF1R, IGF1
4mammary gland developmentGO:03087910.8IGF1, IGF1R, IRS1
5positive regulation of glucose import in response to insulin stimulusGO:200127510.7AKT2, IRS1
6positive regulation of glycogen biosynthetic processGO:04572510.7IGF1, INSR, SORBS1, IRS1, AKT2
7phosphatidylinositol 3-kinase signalingGO:01406510.7PIK3R1, IGF1R, IRS1
8insulin-like growth factor receptor signaling pathwayGO:04800910.7PIK3R1, IGF1, IGF1R, IRS1
9positive regulation of mitosisGO:04584010.7TNF, INSR, IGF1
10sequestering of triglycerideGO:03073010.7ENPP1, TNF
11positive regulation of protein kinase B signalingGO:05189710.7IGF1, IGF1R, INSR, TNF
12cellular response to insulin stimulusGO:03286910.7INSR, SORBS1, IRS1, AKT2, ENPP1, SLC2A4
13positive regulation of glucose metabolic processGO:01090710.7AKT2, IRS1
14positive regulation of glucose importGO:04632610.7AKT2, IRS1, SORBS1, INSR, IGF1, PIK3R1
15positive regulation of DNA replicationGO:04574010.7IGF1, IGF1R, INSR
16positive regulation of cell migrationGO:03033510.7PIK3R1, IGF1R, INSR, IRS1
17positive regulation of fatty acid beta-oxidationGO:03200010.7IRS1, AKT2
18negative regulation of glucose importGO:04632510.7TNF, ENPP1
19phosphatidylinositol-mediated signalingGO:04801510.7IRS1, IGF1R, IGF1, PIK3R1
20positive regulation of MAPK cascadeGO:04341010.7IGF1, IGF1R, INSR
21insulin receptor signaling pathwayGO:00828610.7PIK3R1, IGF1R, INSR, PTPN1, SORBS1, IRS1
22male sex determinationGO:03023810.7INSR, IGF1R
23positive regulation of glycolytic processGO:04582110.6INSR, IGF1
24positive regulation of protein phosphorylationGO:00193410.6INSR, TNF, AKT2
25regulation of JNK cascadeGO:04632810.6MAPK8IP1, IGF1R
26negative regulation of lipid catabolic processGO:05099510.5TNF, BSCL2
27positive regulation of cytokine productionGO:00181910.5AGPAT2, TNF
28positive regulation of transcription from RNA polymerase II promoterGO:04594410.5PIK3R1, IGF1, TNF, HNF1B, HNF4A
29JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.4IRS1, PTPN1
30positive regulation of establishment of protein localization to plasma membraneGO:09000410.4PIK3R1, SORBS1
31positive regulation of cell proliferationGO:00828410.3IRS1, INSR, IGF1R, IGF1
32blood coagulationGO:00759610.1PIK3R1, IGF1, PTPN1, HNF4A

Molecular functions related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.5IRS1, INSR, IGF1, PIK3R1
2phosphatidylinositol 3-kinase bindingGO:04354810.5PIK3R1, IGF1R, INSR, IRS1
3insulin bindingGO:04355910.5INSR, IGF1R, PIK3R1
4insulin receptor bindingGO:00515810.5ENPP1, PIK3R1, IGF1, IGF1R, PTPN1, SORBS1
5fatty acid bindingGO:00550410.4HNF4A, FABP2
6insulin receptor substrate bindingGO:04356010.4PIK3R1, IGF1R, INSR
7insulin-like growth factor I bindingGO:03199410.3INSR, IGF1R
8protein bindingGO:00551510.2PTPN1, TNF, INSR, IGF1R, IGF1, PIK3R1
9transmembrane receptor protein tyrosine kinase adaptor activityGO:00506810.1IRS1, PIK3R1

Products for genes affiliated with Insulin Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Insulin Resistance

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet