Insulin Resistance malady

Wikipedia: Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal...⁴⁴ more...

MalaCards: Insulin Resistance is related to obesity and diabetes mellitus. An important gene associated with Insulin Resistance is PTPRF (protein tyrosine phosphatase, receptor type, F), and among its related pathways are Metabolic pathways and Metabolism of lipids and lipoproteins. The compounds tyrosine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are homeostasis/metabolism and growth/size.

OMIM: 125853

insulin resistance 7 33 32 43

Disease types for insulin resistance family:

insulin-resistance type b

Diseases related to insulin resistance by text searches and GeneDecks gene sharing:

(show top 50)    (show all 822)

id	Related Disease	Score	Top Affiliating Genes
1	obesity	89.7	ZNF318, PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1
2	diabetes mellitus	81.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, COG2
3	carcinoma	79.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
4	cholesterol	74.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
5	pancreatitis	71.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
6	prostatitis	70.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
7	atherosclerosis	68.8	PIK3CG, LRP1, COG2, REN, RETN, CNR1
8	hypertension	67.6	PIK3CB, PIK3R1, PIK3CG, LRP1, COG2, PDE3B
9	type 2 diabetes mellitus	66.5	PIK3R1, COG2, PDE3B, RETN, SGK1, CNR1
10	leukemia	61.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
11	hyperglycemia	60.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, COG2, RETN
12	thyroiditis	59.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, COG2
13	alzheimer's disease	58.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, COG2
14	colorectal cancer	57.2	ZNF318, PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG
15	adenocarcinoma	56.2	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, RELA
16	hypoxia	54.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, RELA
17	fibrosis	54.2	PIK3CA, PIK3CG, LRP1, RELA, REN, RETN
18	arthritis	53.4	PIK3CG, LRP1, RELA, RETN, CNBP, CNR1
19	hyperlipidemia	52.1	PIK3CB, PIK3CG, LRP1, COG2, RETN, VWF
20	lipodystrophy	52.0	LRP1, RETN, RBP4, SERPINE1, BSCL2, NAMPT
21	coronary heart disease	52.0	LRP1, COG2, RETN, VWF, GCKR, GCG
22	rheumatoid arthritis	51.7	PIK3CG, LRP1, RELA, RETN, CNR1, CNTF
23	fatty liver disease	51.5	COG2, RETN, CNR1, PCK2, RBP4, SERPINE1
24	nephropathy	51.2	LRP1, COG2, RELA, REN, RETN, SGK1
25	schizophrenia	51.2	PIK3CB, PIK3CA, PIK3R1, PIK3CG, CNR1, CNTF
26	essential hypertension	50.8	COG2, REN, RETN, SGK1, KISS1, VWF
27	hypertriglyceridemia	49.4	LRP1, COG2, GCKR, RBP4, SELE, SELP
28	myocardial infarction	49.0	PIK3CG, LRP1, COG2, REN, RETN, CNR1
29	ischemia	49.0	PIK3CA, PIK3CG, COG2, RELA, REN, RETN
30	twinning	47.4	ZNF318, PIK3R1, LRP1, COG2, REN, RETN
31	cerebritis	47.3	PIK3R1, PIK3CG, LRP1, COG2, RELA, REN
32	retinitis	46.8	PIK3CA, PIK3CG, LRP1, PDE3B, SGK1, CNBP
33	adenoma	46.5	PIK3CA, REN, RETN, CNR1, CNTF, KISS1
34	peritonitis	46.1	LRP1, COG2, PDE3B, RELA, REN, SGK1
35	hyperandrogenism	45.7	REN, RETN, NAMPT, LMNA, LEP, BAIAP2L1
36	obesity, association with	45.0	RETN, CNR1, VWF, RBP4, SERPINA12, SERPINE1
37	hypoglycemia	43.6	PIK3CG, PCK2, PCSK1, PCK1, GCKR, GCK
38	homocysteine	43.2	PIK3R1, COG2, RELA, REN, RETN, VWF
39	retinol binding protein	43.0	RETN, PCK2, RBP4, NAGLU, NAMPT, LPA
40	apnea	43.0	REN, RETN, VWF, RBP4, SELE, SELP
41	type 1 diabetes mellitus	43.0	PIK3CG, RETN, GCK, GCG, RBP4, NAGLU
42	hypercholesterolemia	42.9	LRP1, COG2, RETN, VWF, GCG, RBP4
43	blindness	42.9	PIK3CG, COG2, REN, CNBP, CNR1, CNTF
44	hyperinsulinism	42.9	RETN, GCKR, GCK, GCG, SELE, SERPINE1
45	polycystic ovary syndrome	42.8	LEP, CGA, CGB5, FST, IRS1, IRS2
46	breast carcinoma	42.6	PIK3CA, PIK3R1, PIK3CG, LRP1, KISS1, VWF
47	sleep apnea	42.6	REN, RETN, VWF, RBP4, SELE, SELP
48	lupus erythematosus	42.3	PIK3CG, COG2, RETN, CNBP, CNTF, VWF
49	gestational diabetes	42.0	RETN, GCK, GCG, RBP4, NAMPT, KCNJ11
50	anorexia nervosa	41.9	COG2, RETN, CNR1, GCG, SERPINE1, LPA

Clinical features from OMIM: 125853

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to insulin resistance:

²²

MGI Mouse Phenotypes related to insulin resistance:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	39.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
2	growth/size phenotype	MP:0005378	32.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, PDE3B
3	mortality/aging	MP:0010768	29.3	PIK3CB, PIK3CA, LRP1, RELA, REN, RETNLB
4	behavior/neurological phenotype	MP:0005386	27.0	PIK3CA, LRP1, REN, CNR1, CNTF, PCSK1
5	cellular phenotype	MP:0005384	25.0	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, CNBP
6	cardiovascular system phenotype	MP:0005385	23.3	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
7	adipose tissue phenotype	MP:0005375	22.8	PIK3CA, PIK3R1, LRP1, PDE3B, RETN, CNR1
8	immune system phenotype	MP:0005387	22.3	LRP1, REN, RETNLB, CNTF, VWF, PCSK1
9	nervous system phenotype	MP:0003631	20.2	LRP1, RELA, REN, CNBP, CNR1, CNTF
10	muscle phenotype	MP:0005369	19.9	PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, RELA
11	liver/biliary system phenotype	MP:0005370	19.6	RETN, VTI1B, PCK1, GCK, SERPINA6, SEPP1
12	normal phenotype	MP:0002873	19.6	PIK3R1, LRP1, KLF11, RELA, REN, PCK1
13	renal/urinary system phenotype	MP:0005367	16.9	REN, SGK1, KISS1, PCBD1, GCK, SELP
14	integument phenotype	MP:0010771	16.9	PIK3CG, PDE3B, RELA, CNR1, KISS1, PCBD1
15	reproductive system phenotype	MP:0005389	16.7	PIK3CA, REN, KISS1, PCSK1, GCGR, RBP4
16	digestive/alimentary phenotype	MP:0005381	16.3	RETNLB, KISS1, VWF, PCSK1, GCG, SERPINF1
17	embryogenesis phenotype	MP:0005380	16.0	PIK3CB, PIK3CA, CNBP, PCNT, SETD2, MYOG
18	no phenotypic analysis	MP:0003012	15.8	PIK3R1, SGK1, CNR1, PCK1, SERPINA6, BSCL2
19	hematopoietic system phenotype	MP:0005397	15.0	CNTF, PCSK1, BSCL2, USP4, CMKLR1, ZFP36
20	skeleton phenotype	MP:0005390	15.0	PIK3CG, LRP1, RELA, CNBP, CNR1, SEPN1
21	endocrine/exocrine gland phenotype	MP:0005379	14.3	KISS1, VTI1B, PCSK1, SELL, BDKRB2, KCNJ11
22	vision/eye phenotype	MP:0005391	14.2	PIK3CA, RELA, CNBP, VTI1B, PCBD1, RBP4
23	craniofacial phenotype	MP:0005382	14.1	CNBP, NAGLU, LIAS, PBX1, BDNF, MSTN
24	respiratory system phenotype	MP:0005388	14.0	SELL, SELP, LPL, MYOG, MYOD1, RAB3C
25	tumorigenesis	MP:0002006	13.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, KLF11, SELL
26	hearing/vestibular/ear phenotype	MP:0005377	12.8	NAGLU, VDR, LMNA, BMP7, PBX1, BDNF
27	limbs/digits/tail phenotype	MP:0005371	12.5	RELA, PCNT, SEPP1, VEGFA, VDR, LMNA
28	other phenotype	MP:0005395	11.0	CNR1, CLU, PBX1, KDR, LEPR, LDLR

Articles related to insulin resistance:

(show top 50)    (show all 3738)

id	Title	Authors	Year	Affiliating Genes
1	Reduction of insulin resistance with effective cleara nce of hepatitis C infection: results from the HALT-C trial. (20156586)	Delgado-Borrego A.... Chung R.T.	2010	ADIPOQ
2	Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance. (19949414)	Moreno-Navarrete J.M.... FernA!ndez-Real J.M.	2010	LCN2
3	Dissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt. (20022950)	Ng Y.... James D.E.	2010	INSR, INS
4	Plasma visfatin concentrations in childhood obesity: relationships with insulin resistance and anthropometric indices. (19142752)	Davutoglu M.... Kilinc M.	2009	NAMPT
5	Association of urinary albumin excretion with insulin resistance in Japanese subjects: impact of gender difference on insulin resist ance. (19755764)	Utsunomiya K.... Tajima N.	2009	ALB
6	Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. (18401671)	Catalan V.... Fruhbeck G.	2008	INS, AQP7, AQP9
7	Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa. (17919459)	Nakahara T.... Inui A.	2008	GHRL
8	Correlation of calculated indices of insulin resistance (QUICKI and HOMA) with the euglycaemic hyperinsulinaemic clamp technique for evaluating insulin resistance in critically ill patients. (17655809)	Holzinger U.... Ratheiser K.	2007	INS
9	Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine. (16644688)	Federico L.M.... Adeli K.	2006	PTPN1, INS
10	Prediction models for insulin resistance in girls wit h premature adrenarche. The premature adrenarche insulin resistance score: PAIR score. (16549934)	Vuguin P.... DiMartino Nardi J.	2006	INS
11	Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance. (16691186)	Nolsoe R.L.... Mandrup-Poulsen T.	2006	FAS, FASLG
12	The frequency of insulin resistance calculated upon the basis of a fasting glucose to insulin ratio and characteristics of insulin resistant women with polycystic ovary syndrome. (16985482)	Popovska-Dimova Z.... Krstevska B.	2006	SHBG
13	Selective insulin resistance affecting nitric oxide release but not plasminogen activator inhibitor-1 synthesis in fibroblasts from insulin-resistant individuals. (16151016)	Pandolfi A.... Consoli A.	2005	SERPINE1
14	Serum levels of soluble tumor necrosis factor-alpha receptor 2 are linked to insulin resistance and glucose intolerance in children. (15679072)	Gupta A.... Anhalt H.	2005	INS
15	Insulin resistance, LDL particle size, and LDL susceptibility to oxidation in pediatric kidney and liver recipients. (15840056)	Siirtola A.... Salo M.K.	2005	APOA1
16	Insulin resistance and adiposity influence lipoprotein size and subclass concentrations. Results from the Insulin Resistance Atherosclerosis Study. (15690322)	Goff D.C.... Otvos J.D.	2005	INS
17	Insulin resistance in obese adolescents. (16302580)	Li H.J.... Lee Y.J.	2005	INS
18	Effects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients. (15811141)	Faria A.N.... Zanella M.T.	2005	LEP, INS
19	Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome. (15598674)	Ortega-GonzA!lez C.... Parra A.	2005	INS
20	Insulin resistance, the insulin resistance syndrome, and cardiovascular disease. (16489319)	Reaven G.M.	2005	SERPINE1, INS
21	Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. (14962155)	Abbatecola A.M.... Paolisso G.	2004	IL6
22	Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease. (15365613)	Wannamethee S.G.... Whincup P.H.	2004	INS
23	Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance. (15542929)	Bahceci M.... Aslan C.	2004	CRP, PRL, INS
24	Insulin resistance and hypertension: the Insulin Resistance Atherosclerosis study. (15123571)	Saad M.F.... Haffner S.M.	2004	INS
25	Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. (12663464)	Brozinick J.T.... Dohm G.L.	2003	AKT2, AKT1, AKT3
26	Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. (12952969)	Rotter V.... Smith U.	2003	TNF, IL6, IL8
27	Plasma ghrelin, body fat, insulin resistance, and smoking in clinically healthy men: the atherosclerosis and insulin resistance study. (14624407)	Fagerberg B.... Hulthe J.	2003	GHRL
28	Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. (14557464)	Lee J.H.... Mantzoros C.S.	2003	RETN, LSL
29	C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients. (12489071)	Taniguchi A.... Nakai Y.	2002	CRP
30	NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. (11826411)	Chitturi S.... George J.	2002	INS
31	Skeletal muscle triglyceride. An aspect of regional a diposity and insulin resistance. (11347757)	Kelley D.E.... Goodpaster B.H.	2001	INS
32	Temporary reversal by topotecan of marked insulin resistance in a patient with myelodysplastic syndrome: case report and possible mechanism for tumor necrosis factor alpha (TNF-alpha)-induced insulin resistance. (11404500)	Huntington M.O.... Liljenquist J.E.	2001	INSR, INS
33	Insulin resistance in essential hypertension: a psych ophysiological approach to the 'chicken and egg' question. (11213537)	Nazzaro P.... Pirrelli A.M.	2000	INS
34	Clinical significance and pathogenic mechanisms of insulin resistance in chronic renal insufficiency (part II): pathogenic factors of insulin resistance in chronic renal insufficiency (10965681)	RasiA8-MilutinoviA8 Z.... Pljesa S.	2000	INS
35	Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). (10880413)	Festa A.... Haffner S.M.	2000	CRP
36	Clinical importance and pathogenic mechanisms of insulin resistance in chronic renal insufficiency (part I): insulin resistance in patients with chronic renal insufficiency (10953550)	RasiA8-MilutinoviA8 Z.... PeruniciA8-PekoviA8 G.	2000	INS
37	The relation between insulin resistance and cardiovascular complications of the insulin resistance syndrome. (11220289)	Rett K.	1999	PPARG
38	Gender differences in the relation between fibrinogen, tissue-type plasminogen activator antigen and markers of insulin resistance: effects of smoking. D.E.S.I.R. Study Group. Data from an Epidemiological Study on Insulin Resistance Syndrome. (10494772)	Mennen L.I.... le Mauff J.M.	1999	INS
39	Dominant negative mutations in human PPAR-gamma associated with severe insulin resistance, diabetes mellitus and hypertension. (10622252)	Barroso I.... O'Rahilly S.	1999	PPARG, ESRRB
40	Disordered expression of the sucrase-isomaltase compl ex in the small intestine in Otsuka Long-Evans tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance. (9878708)	Adachi T.... Nakano Y.	1999	SI
41	Cellular mechanism of nutritionally induced insulin resistance: the desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome. (10212843)	SHAFRIR E.... Ziv E.	1998	INSR, INS, TKT
42	Relationships between insulin resistance and lipoproteins in nondiabetic African Americans, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study. (9781617)	Howard B.V.... Haffner S.M.	1998	INS
43	Plasma amylin immunoreactivity and insulin resistance in insulin resistant relatives of patients with non-insulin-dependent diabetes mellitus. (9623635)	Nyholm B.... Schmitz O.	1998	IAPP
44	Analysis of the insulin receptor gene tyrosine kinase domain in obese patients with hyperandrogenism, insulin resistance and acanthosis nigricans (type C insulin resistance). (9578241)	Globerman H.... Karnieli E.	1998	INS, BAIAP2L1
45	Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance. (9486982)	Dib K.... O'Rahilly S.	1998	INSR, INS
46	Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study. (9588452)	MykkAonen L.... Haffner S.M.	1998	ALB, INS
47	Does insulin resistance unite the separate components of the insulin resistance syndrome? Evidence from the Miami Community Health Study. (9409209)	Donahue R.P.... Prineas R.J.	1997	TTF2
48	Insulin resistance in young salt-sensitive normotensive subjects. (8478036)	Sharma A.M.... Distler A.	1993	SST
49	Insulin resistance and hyperinsulinemia induce hyperandrogenism in a young type B insulin-resistant female. (2026751)	DeClue T.J.... Malone J.I.	1991	HSD3BP4
50	Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance). (2460770)	Moller D.E.... Flier J.S.	1988	INSR

Genes related to insulin resistance according to GeneCards:

(show top 50)    (show all 665)

id	Symbol	Description	Score	GeneCards Section Context
1	PTPRF	protein tyrosine phosphatase, receptor type, F	11.1	Summaries, Publications
2	INSR	insulin receptor	11.1	Publications, Summaries
3	IRS1	insulin receptor substrate 1	11.1	Publications, Summaries
4	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.1	Publications, Summaries
5	AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	11.1	Publications, Summaries
6	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	11.1	Publications, Summaries
7	FABP2	fatty acid binding protein 2, intestinal	11.1	Publications, Summaries
8	PEA15	phosphoprotein enriched in astrocytes 15	11.1	Publications, Summaries
9	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	11.1	Publications, Summaries
10	IGF1	insulin-like growth factor 1 (somatomedin C)	11.1	Publications, Summaries
11	TNF	tumor necrosis factor	11.1	Publications, Functions, Summaries
12	IGF1R	insulin-like growth factor 1 receptor	11.1	Publications, Summaries
13	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	11.1	Publications, Summaries
14	CIDEC	cell death-inducing DFFA-like effector c	11.0	Publications, Summaries
15	SLC27A4	solute carrier family 27 (fatty acid transporter), member 4	11.0	Publications, UniProt Related, Summaries
16	RETN	resistin	11.0	Publications
17	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
18	PPP1R3A	protein phosphatase 1, regulatory subunit 3A	11.0	Publications
19	PTPN1	protein tyrosine phosphatase, non-receptor type 1	11.0	Publications
20	INS	insulin	11.0	Publications
21	SOD3	superoxide dismutase 3, extracellular	11.0	Publications
22	LEPR	leptin receptor	11.0	Publications
23	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	11.0	Publications
24	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	11.0	Publications
25	LPIN3	lipin 3	11.0	Summaries
26	LPIN2	lipin 2	11.0	Summaries
27	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications, UniProt Related
28	RBP4	retinol binding protein 4, plasma	11.0	Publications
29	IRS2	insulin receptor substrate 2	11.0	Publications
30	SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	11.0	Publications
31	LSL	Leptin, serum levels of	11.0	Publications
32	RRAD	Ras-related associated with diabetes	11.0	Publications, Functions
33	SHBG	sex hormone-binding globulin	11.0	Publications
34	ADIPOR1	adiponectin receptor 1	11.0	Publications
35	ADRB3	adrenoceptor beta 3	11.0	Publications
36	GYS1	glycogen synthase 1 (muscle)	11.0	Publications
37	LEP	leptin	11.0	Publications
38	MSBP1	minisatellite binding protein 1	11.0	Publications
39	NAMPT	nicotinamide phosphoribosyltransferase	11.0	Publications
40	ADIPOR2	adiponectin receptor 2	11.0	Publications
41	CAPN10	calpain 10	11.0	Publications
42	DIO2	deiodinase, iodothyronine, type II	11.0	Publications
43	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	11.0	Publications
44	IAPP	islet amyloid polypeptide	11.0	Publications
45	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
46	ITLN1	intelectin 1 (galactofuranose binding)	11.0	Publications
47	PAX4	paired box 4	11.0	Publications
48	PNPLA2	patatin-like phospholipase domain containing 2	11.0	Publications
49	RARRES2	retinoic acid receptor responder (tazarotene induced) 2	11.0	Publications
50	RETNLB	resistin like beta	11.0

Pathways related to insulin resistance according to GeneDecks:

(show top 50)    (show all 352)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	17.6	PCK2, PCK1, GCK, GCH1, NAGLU, LIAS
2	Metabolism of lipids and lipoproteins38	15.4	LPIN1, LPIN2, LPIN3, LPL, LIPE, SCARB1
3	Akt Signaling36	15.2	PIK3R1, PIK3CG, PDE3B, BMP7, UTS2, CHUK
4	cAMP Pathway36	14.5	PIK3R2, PIK3R1, PDE3B, GCG, GCGR, BMP6
5	Development IGF-RI signaling10	13.9	PIK3CB, PIK3CA, PIK3R1, RELA, CHUK, YWHAB
6	Development Leptin signaling via PI3K-dependent pathway10	13.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PDE3B, KCNJ11
7	NFAT and Cardiac Hypertrophy36	13.2	PIK3R2, PIK3R1, GSK3B, MEF2A, IL11, IL6
8	Signaling Involved in Cardiac Hypertrophy36	13.0	PIK3R2, PIK3R1, RAC1, JUN, JAK2, IRS1
9	Translation _Regulation of EIF2 activity41	13.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, IRS1, IRS2
10	Development_Thrombopoietin-regulated cell processes41	12.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAC1, JUN
11	Statin Pathway, Pharmacodynamics34	12.9	LRP1, LPL, LIPC, SCARB1, LDLR, LCAT
12	Neurotrophin signaling pathway20	12.9	PIK3CB, PIK3CA, PIK3R2, PIK3CG, RELA, RAC1
13	PI3K / Akt Signaling3	12.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, SGK1
14	Influenza A20	12.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA
15	Development_CNTF receptor signaling41	12.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, CNTF, CLCF1
16	Jak-STAT signaling pathway20	12.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, CNTF
17	Development_Endothelin-1/EDNRA transactivation of EGFR41	12.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, MTOR, FOS
18	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis10	12.7	PIK3CB, PIK3CA, PIK3R2, PIK3R1, MYOG, MYOD1
19	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways37	12.7	PIK3CB, PIK3R1, PIK3CG, FOXO1, FOXO3, IRS1
20	Translation _Regulation of EIF4F activity41	12.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAC1, MTOR
21	Transcription PPAR Pathway10	12.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, MAP2K6, MAPK3
22	Immune response_IL-9 signaling pathway41	12.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, CISH
23	Development FGFR signaling pathway10	12.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAC1, JUN
24	Erythropoietin Pathway36	12.4	PIK3R2, PIK3R1, JUN, JAK2, FOS, MAPK8
25	Development_Flt3 signaling41	12.3	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAC1, JUN
26	TGF-beta Signaling Pathways37	12.2	PIK3CB, PIK3R2, PIK3R1, PIK3CG, RELA, MYOD1
27	Toll-like receptor signaling pathway20	12.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA
28	Translation Insulin regulation of translation10	12.0	PIK3CB, PIK3R2, PIK3R1, IRS1, GSK3B, AKT2
29	Development Prolactin receptor signaling10	12.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, RAC1
30	Development_Neurotrophin family signaling41	12.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RAC1, BDNF
31	Estrogen Pathway36	11.9	PIK3R2, PIK3R1, BMP6, BMP7, UTS2, BDNF
32	CD40 Signaling36	11.8	PIK3R2, MAPK8, MAP2K6, MAP3K14, MAPK10, MAPK1
33	IL-2 Pathway36	11.7	PIK3R2, PIK3R1, CHUK, JUN, FOS, MAPK8
34	Renin-Angiotensin Pathway36	11.7	PIK3R2, PIK3R1, REN, VCAM1, BMP6, BMP7
35	Focal adhesion20	11.7	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, VWF
36	IL-3 Pathway36	11.7	PIK3R2, PIK3R1, CHUK, YWHAB, YWHAE, YWHAG
37	SUMO Pathway36	11.6	CHUK, IL1B, IL1R1, MAPK8, MAP2K6, MAPK14
38	NFAT in Immune Response36	11.6	PIK3R2, PIK3R1, BMP6, BMP7, UTS2, BDNF
39	VEGF Signaling Pathway34	11.5	VEGFA, KDR, MAPK8, MAP2K6, MAPK3, MAPK14
40	MAP Kinase Signaling3	11.5	RAC1, YWHAB, YWHAE, YWHAQ, JUN, FOS
41	Colorectal cancer20	11.4	PIK3CB, PIK3R2, PIK3R1, PIK3CG, RAC1, FOS
42	Cellular Apoptosis Pathway36	11.2	PIK3R2, PIK3R1, BMP6, BMP7, UTS2, BDNF
43	Immune response IL-6 signaling pathway10	11.0	RELA, CEBPD, FOS, IL6, IL6R, IL6ST
44	Pathways in cancer20	11.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA
45	Rac1 Pathway36	11.0	PIK3R2, PIK3R1, BMP6, BMP7, RAC1, UTS2
46	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.9	LEPR, JAK2, PTPN1, PTPN11, EGR1, TIMP1
47	Immune response Oncostatin M signaling via MAPK in human cells10	10.9	RAC1, JUN, FOS, IL6ST, MAPK8, MAPK3
48	Bacterial infections in CF airways41	10.7	RELA, SFTPA1, CHUK, IL1R1, IL1RAP, MAP3K14
49	Immune response_IL-1 signaling pathway41	10.0	RELA, SERPINE1, CHUK, JUN, FOS, IL1B
50	Malaria20	9.3	LRP1, SELE, SELP, VCAM1, CD36, CD40LG

Compounds related to insulin resistance according to GeneDecks:

(show top 50)    (show all 498)

id	Compound	Score	Top Affiliating Genes
1	tyrosine32	31.3	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, PDE3B
2	estrogen32	24.7	PIK3CB, PIK3R1, COG2, RETN, KISS1, VWF
3	glycogen32 18	24.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, RETN
4	oxygen32 18	22.7	GCK, GCH1, RBP4, SETD2, SERPINF1, SEPP1
5	lactate32	19.0	PIK3CA, VWF, PCK2, GCK, GCG, RBP4
6	superoxide32 18	18.8	PIK3CA, PIK3R1, PDE3B, CNTF, GCH1, SELL
7	dopamine32 9 18 9	20.6	PIK3CA, PDE3B, REN, CNTF, GCG, GCH1
8	fibrinogen32	17.6	PIK3CB, COG2, RETN, SELE, SELP, SERPINE1
9	palmitate32	16.6	GCG, SELE, LIPA, SCD, SCP2, LDLR
10	vitamin a32 9 18 9	19.4	RETN, VWF, PCK2, RBP4, SERPINA6, SERPINA3
11	fenofibrate32 9 9	18.1	COG2, RETN, SELE, SELP, SERPINE1, LPA
12	acth32	16.0	PDE3B, REN, PCSK1, SERPINA6, PBX1, BDNF
13	aspartate32	15.8	PIK3R1, RETN, CNR1, PCK2, PCNT, RBP4
14	carnitine32	15.2	PCK2, PCK1, LPL, LIPE, CHKB, UCP1
15	bezafibrate32 9 9	17.0	COG2, SERPINE1, LPA, LPL, LIPC, CHKB
16	troglitazone32 42 9 9	17.5	PIK3CG, PCK2, SELE, SERPINE1, LPL, VDR
17	2-deoxyglucose32	14.4	PIK3R1, PIK3CG, GCK, LIPE, BAIAP2L1, FOS
18	chloramphenicol32 9 9	16.2	SGK1, PCK2, SELE, SETD2, SERPINE1, LPL
19	ibmx32	14.0	PDE3B, PCK2, PCSK1, GCG, LPL, VCAM1
20	phosphoenolpyruvate32 9 9	15.8	PCK2, PCK1, GCK, FOXO1, IRS1, FABP1
21	gaba32 42	14.2	CNR1, CNTF, GCG, BDKRB2, BDNF, CHGA
22	lysine32	13.1	RELA, MYOD1, KCNJ11, CISH, CHKB, CHUK
23	carbon32	13.0	CNR1, VWF, NAGA, LPL, VDR, LIPE
24	cgmp32	13.0	PDE3B, REN, PCSK1, GCH1, LPA, LIPE
25	sialic acid32	12.8	RBP4, SELL, SERPINA6, SERPINA3, NAGLU, LPA
26	clozapine32 34 9 9	15.8	BDNF, SCD, LEP, CHKB, MPO, FOS
27	orlistat32 42 9 9	15.7	CNR1, GCG, LPL, LIPC, LEP, INS
28	retinoid32	12.6	PCK2, RBP4, SELL, VDR, BMP6, RARRES2
29	intralipid32	12.5	LPL, LIPC, LEP, UCP3, LCAT, CETP
30	sodium nitroprusside32	12.5	REN, VWF, BMP6, BDKRB2, CGA, CGB5
31	cytochalasin d32 42	13.4	PIK3CG, VWF, SELE, SELL, LPL, VCAM1
32	vitamin b1232	12.4	VWF, SERPINA3, LPA, MTHFR, MTR, MPO
33	prostaglandin f2alpha32	12.3	SERPINE1, LPL, CGA, CGB5, FABP12, MAPK3
34	carbamazepine32 34 9 9	15.2	COG2, NAGLU, CD36, IGFBP3, ALPP, GLUD1
35	succinate32	12.2	SELE, SETD2, CHKB, UCP2, MMP9, FASN
36	tocopherol32	12.0	RBP4, LPL, SCARB1, LDLR, APOA1, APOB
37	nicotine32 34 9 9	15.0	SELL, GPT, HSD11B2, CYP1A2, CYP2E1, CYP2D6
38	c2ceramide32	11.9	PIK3CG, MYOG, CHUK, CGB5, JUN, IRS1
39	ursodeoxycholic acid32 9 18 9	14.8	LPA, BMP6, LDLR, CD40LG, APOE, CCK
40	sp 60012532 42	12.8	PIK3CG, VCAM1, CD40, MAP3K14, MAP2K7, IKBKB
41	atropine32 9 9	13.8	GCG, UTS2, BCHE, CCK, GNAI1, HSPG2
42	diphenyleneiodonium32	11.2	SETD2, SERPINF1, VEGFA, VCAM1, RAC1, MPO
43	5-aza-2deoxycytidine32	11.1	MYOD1, BMP6, CLU, CISH, FST, JAK2
44	progestin32	11.1	PIK3R1, VEGFA, KDR, CGA, CGB5, AR
45	25-hydroxyvitamin d32	10.9	VDR, BGLAP, LEP, ALPP, CASR, TNFRSF11B
46	ramipril32 9 9	12.9	REN, SERPINE1, BCHE, INS, ALB, HMGCR
47	neomycin32	10.6	PCK2, SCP2, MAPK3, CCK, IGF2, F9
48	ciglitazone32	10.4	SERPINE1, JUN, MMP9, IL1B, IL6, IL8
49	5fluorouracil32	10.2	PIK3CA, PIK3CG, GCG, SELE, VEGFA, VDR
50	desmopressin32 42 9 9	13.1	REN, VWF, SELP, SERPINE1, NAGLU, AVP

Cellular components related to insulin resistance according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	24.2	PIK3R1, PIK3CG, SGK1, CNR1, GCG, GCGR
2	cytosol	GO:005829	22.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PDE3B
3	cytoplasm	GO:005737	21.0	ZNF318, PIK3CG, LRP1, RELA, PCBD1, PCNT
4	extracellular region	GO:005576	19.1	RETN, RETNLB, KISS1, VWF, SFTPA1, GCG
5	extracellular space	GO:005615	16.8	REN, CNTF, SFTPA1, PCSK1, GCG, RBP4
6	endoplasmic reticulum	GO:005783	14.2	PDE3B, CNBP, VWF, RAB1A, CLU, SCD
7	nucleoplasm	GO:005654	14.1	RELA, GCKR, GCK, VDR, LMNA, MYOG
8	high-density lipoprotein particle	GO:034364	11.8	LIPC, LCAT, SAA1, CETP, APOA1, APOA2
9	perinuclear region of cytoplasm	GO:048471	11.8	PCSK1, SELE, VLDLR, LPXN, LMNA, RAB8A
10	caveola	GO:005901	11.5	SELE, LIPE, SCARB1, JAK2, IRS1, INSR
11	cell surface	GO:009986	11.4	VLDLR, VEGFA, LPL, VCAM1, SCARB1, LDLR
12	external side of plasma membrane	GO:009897	11.2	VWF, SELL, SELP, VCAM1, KDR, LDLR
13	secretory granule	GO:030141	11.0	PCSK1, GCK, GCG, VEGFA, CHGA, AVP
14	platelet alpha granule lumen	GO:031093	8.9	VWF, SERPINE1, VEGFA, CLU, APP, IGF1

Biological processes related to insulin resistance according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	25.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PCBD1
2	signal transduction	GO:007165	16.8	PIK3CB, CNTF, GCG, VLDLR, NAMPT, LPXN
3	insulin receptor signaling pathway	GO:008286	15.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PDE3B, NAMPT
4	lipid metabolic process	GO:006629	15.0	LPA, LPIN2, LPL, LIPE, CLU, SCARB1
5	cellular lipid metabolic process	GO:044255	15.0	LPIN1, LPIN2, SCP2, CD36, APOA1, APOA2
6	glucose metabolic process	GO:006006	14.5	PIK3CA, PCK2, PCK1, SERPINA12, KCNJ11, LEP
7	energy reserve metabolic process	GO:006112	13.9	PCSK1, GCG, GCGR, KCNJ11, LEP, LEPR
8	cellular response to insulin stimulus	GO:032869	13.8	PDE3B, GCK, VLDLR, IRS1, IRS2, INHBB
9	negative regulation of apoptotic process	GO:043066	13.5	PIK3CG, RELA, GCG, SERPINE1, VEGFA, CLCF1
10	glucose homeostasis	GO:042593	13.5	PDE3B, PCK1, GCK, RBP4, SERPINE1, IRS1
11	apoptotic process	GO:006915	13.5	KLF11, SGK1, PCNT, LMNA, RAC1, ZBTB16
12	positive regulation of cell proliferation	GO:008284	13.4	CNBP, CNTF, NAMPT, VEGFA, CLCF1, KDR
13	cholesterol homeostasis	GO:042632	13.3	LIPC, SCARB1, LDLR, LCAT, CETP, APOA1
14	cholesterol metabolic process	GO:008203	13.3	VLDLR, LIPE, LIPC, LEP, LEPR, LDLR
15	nerve growth factor receptor signaling pathway	GO:048011	13.2	PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, RAC1
16	innate immune response	GO:045087	13.2	PIK3CG, RELA, CLU, CHUK, LCN2, CFB
17	positive regulation of transcription from RNA polymerase II promoter	GO:045944	13.1	RELA, CNBP, SERPINE1, VEGFA, LPIN2, VDR
18	phosphatidylinositol-mediated signaling	GO:048015	12.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, CHUK, MTOR
19	fibroblast growth factor receptor signaling pathway	GO:008543	12.9	PIK3CA, PIK3R1, CHUK, YWHAB, MTOR, CDK1
20	response to nutrient	GO:007584	12.9	CNR1, GCGR, VLDLR, VCAM1, UCP3, MTOR
21	lipoprotein metabolic process	GO:042157	12.8	LPA, LPL, SCARB1, LDLR, LCAT, MTTP
22	response to insulin stimulus	GO:032868	12.8	PCK1, RBP4, LEP, UCP3, FOXA2, IRS1
23	cell-cell signaling	GO:007267	12.7	PCSK1, NAMPT, CGA, AVP, FZD1, CD80
24	positive regulation of glucose import	GO:046326	12.7	PIK3R1, ITLN1, IRS1, IRS2, INS, INSR
25	triglyceride metabolic process	GO:006641	12.6	LPL, CETP, APOA2, APOA5, APOC1, APOC3
26	response to glucocorticoid stimulus	GO:051384	12.5	PCK2, PCSK1, SERPINF1, SERPINE1, BGLAP, BCHE
27	response to glucose stimulus	GO:009749	12.5	PCSK1, IRS2, INSR, APOA2, ANGPT2, MAPK14
28	positive regulation of MAPK cascade	GO:043410	12.3	CNTF, KDR, LEP, CD36, AR, INS
29	blood coagulation	GO:007596	12.3	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, PDE3B
30	toll-like receptor signaling pathway	GO:002224	12.2	RELA, CHUK, JUN, CDK1, FOS, MEF2A
31	MyD88-dependent toll-like receptor signaling pathway	GO:002755	12.2	RELA, CHUK, JUN, CDK1, FOS, MEF2A
32	Toll signaling pathway	GO:008063	12.1	RELA, CHUK, JUN, CD14, CDK1, FOS
33	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.1	VEGFA, MTOR, JAK2, CD36, CD3E, CD80
34	MyD88-independent toll-like receptor signaling pathway	GO:002756	12.1	RELA, CHUK, JUN, CDK1, FOS, MEF2A
35	toll-like receptor 3 signaling pathway	GO:034138	12.1	RELA, CHUK, JUN, CD14, CDK1, FOS
36	TRIF-dependent toll-like receptor signaling pathway	GO:035666	12.1	RELA, CHUK, JUN, CD14, CDK1, FOS
37	toll-like receptor 1 signaling pathway	GO:034130	12.1	RELA, CHUK, JUN, CDK1, FOS, MEF2A
38	toll-like receptor 2 signaling pathway	GO:034134	12.1	RELA, CHUK, JUN, CDK1, FOS, MEF2A
39	toll-like receptor 4 signaling pathway	GO:034142	12.1	RELA, CHUK, JUN, CD14, CDK1, FOS
40	anti-apoptosis	GO:006916	11.9	PIK3CA, RELA, BDNF, YWHAZ, MPO, CD40LG
41	response to organic cyclic compound	GO:014070	11.7	SELP, JUN, CDK1, ANGPT2, CCND1, F7
42	response to lipopolysaccharide	GO:032496	11.7	CNR1, PCSK1, GCH1, SELE, SELP, LIAS
43	organ regeneration	GO:031100	11.7	CEBPA, CDK1, APOA2, APOA5, APOH, ANGPT2
44	epidermal growth factor receptor signaling pathway	GO:007173	11.6	PIK3CA, PIK3R1, CHUK, YWHAB, MTOR, CDK1
45	platelet activation	GO:030168	11.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, VWF
46	regulation of insulin secretion	GO:050796	11.5	CNR1, PCSK1, GCK, GCG, KCNJ11, LEP
47	regulation of blood pressure	GO:008217	11.4	REN, SGK1, GCGR, GCH1, UTS2, LEP
48	inflammatory response	GO:006954	11.2	PIK3CG, RELA, SELE, SELP, SERPINA3, BMP6
49	aging	GO:007568	11.1	CNR1, SERPINF1, VDR, VCAM1, UCP3, JUN
50	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.8	RELA, RAB7B, CLU, CHUK, CD40, AR

Molecular functions related to insulin resistance according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	30.7	CALCA, ERN1, TXN, TRIB3, TRIM37, TNF
2	protein homodimerization activity	GO:042803	14.5	PTS, PTGS2, PYCARD, TRIM37, HMGCR, HMOX1
3	receptor binding	GO:005102	13.7	ARRB2, AR, INHA, APLN, APP, FASLG
4	hormone activity	GO:005179	13.0	RETN, RETNLB, GCG, UTS2, GH1, PTH
5	protein kinase binding	GO:019901	12.9	RHEB, PDPK1, HIF1A, TCF7L2, STAT3, ADIPOR1
6	protein heterodimerization activity	GO:046982	12.6	ADD1, ADIPOR2, ADIPOR1, ADORA1, CEBPA, FZD1
7	insulin receptor binding	GO:005158	12.2	SLC2A2, SORBS1, SHC1, PDPK1, PTPN11, IRS1
8	insulin-like growth factor receptor binding	GO:005159	11.4	SHC1, SOCS1, IGF1, IGF2, INSR, INS
9	steroid hormone receptor activity	GO:003707	11.3	PPARG, ESRRB, ESRRA, ESR2, ESR1, HNF4A
10	cytokine activity	GO:005125	10.6	MIF, IFNA2, FASLG, IL6, IL18, IL11
11	enzyme binding	GO:019899	10.3	PPARG, YWHAH, PRKCA, ESR2, HMOX1, HMGA1
12	growth factor activity	GO:008083	10.2	GH1, AMH, IGF1, IGF2, IL6, CTGF