MCID: INS005
MIFTS: 66

Insulin Resistance malady

Genetic diseases, Rare diseases, Endocrine diseases categories

Summaries for Insulin Resistance

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal... more...

MalaCards: Insulin Resistance is related to obesity and polycystic ovary syndrome. An important gene associated with Insulin Resistance is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Insulin-mediated glucose transport and Signaling events mediated by PTP1B. The compounds vanadium and ag 1024 have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and skeletal muscle, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Description from OMIM:48 125853

Aliases & Classifications for Insulin Resistance

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48OMIM, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

insulin resistance 48 46 63


Related Diseases for Insulin Resistance

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18GeneCards, 19GeneDecks
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Diseases in the Insulin Resistance family:

Insulin-Resistance Type B

Diseases related to Insulin Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1obesity32.2IRS1, SORBS1, PTPRF, PTPN1, HSD11B1, TNF
2polycystic ovary syndrome31.9IGF1, IGF1R, INSR, IRS1
3hypertension31.8HSD11B1, INSR, IGF1
4diabetes mellitus31.7FABP2, IRS1, PTPN1, HSD11B1, TNF, INSR
5atherosclerosis31.7IGF1, TNF, HSD11B1, PTPN1, IRS1, FABP2
6acanthosis nigricans31.7BSCL2, IGF1, IGF1R, INSR, AGPAT2
7glucose intolerance31.6IGF1, INSR, HSD11B1, ENPP1, SLC2A4
8fatty liver disease31.5HNF4A, FABP2, INSR
9hyperandrogenism31.5IGF1, IGF1R, INSR
10lipodystrophy31.4AGPAT2, AKT2, HSD11B1, INSR, BSCL2
11type 2 diabetes mellitus31.4SLC2A4, HNF4A, HNF1B, MAPK8IP1, AKT2, IRS1
12hypertriglyceridemia31.3BSCL2, INSR, IRS1, FABP2, SLC2A4
13hyperglycemia31.3IGF1, IGF1R, INSR, HSD11B1, IRS1, HNF1B
14gestational diabetes31.3INSR, IRS1, HNF4A, ENPP1, SLC2A4
15hyperinsulinism31.0IGF1, INSR, IRS1
16uremia30.9IGF1, INSR, ENPP1
17metabolic syndrome x30.8SLC2A4, HSD11B1
18rabson-mendenhall syndrome30.8IGF1, INSR
19breast cancer30.8PIK3R1, IGF1, IGF1R, INSR, PTPN1, PTPRF
20hypoglycemia30.8IGF1, INSR, HNF4A, SLC2A4
21type 1 diabetes mellitus30.8IGF1, INSR, HNF4A, ENPP1
22alzheimer's disease30.7MAPK8IP1, PTPN1, INSR, PIK3R1
23liver cirrhosis30.7SLC2A4, IRS1, INSR
24familial partial lipodystrophy30.7AGPAT2, BSCL2
25pancreatic cancer30.5PIK3R1, IGF1, IGF1R, IRS1, AKT2, HNF4A
26adenoma30.5IGF1, IGF1R, INSR, HSD11B1, HNF4A
27sepsis30.5INSR, TNF, IRS1, SLC2A4
28colorectal cancer30.4PPP1R3A, IGF1, IGF1R, INSR, IRS1, HNF4A
29ischemia30.4INSR, FABP2, MAPK8IP1, SLC2A4
30congenital generalized lipodystrophy type 230.4BSCL2, INSR, AGPAT2
31prostate cancer30.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
32maturity-onset diabetes of the young30.2HNF4A, HNF1B
33adenocarcinoma30.2PIK3R1, IGF1R, INSR, HSD11B1, AKT2, HNF1B
34colon cancer30.1HNF4A, IRS1, IGF1R, PIK3R1
35hepatocellular carcinoma30.0PIK3R1, IGF1R, INSR, IRS1, HNF1B, HNF4A
36hepatitis11.1
37liver disease11.0
38endotheliitis10.9
39essential hypertension10.9
40hepatitis c10.9
41artery disease10.8
42coronary artery disease10.8
43kidney disease10.7
44hepatitis c virus10.6
45pancreatitis10.6
46nonalcoholic steatohepatitis10.6
47morbid obesity10.6
48familial combined hyperlipidemia10.6
49arthritis10.6
50acromegaly10.5

Graphical network of the top 20 diseases related to Insulin Resistance:



Diseases related to insulin resistance

Symptoms for Insulin Resistance

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48OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Insulin Resistance

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Insulin Resistance

Drug clinical trials:

Search ClinicalTrials for Insulin Resistance

Search NIH Clinical Center for Insulin Resistance

Search CenterWatch for Insulin Resistance

Genetic Tests for Insulin Resistance

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Anatomical Context for Insulin Resistance

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34MalaCards
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MalaCards organs/tissues related to Insulin Resistance:

34
Ovary, Liver, Skeletal muscle, Adipocyte, Heart, Endothelial, Kidney, Pancreas, Testes, Monocytes, Bone, Thyroid, Breast, Brain, Skin, Prostate, Colon, B cells, Smooth muscle, Pituitary, Lung, T cells, Small intestine, Myeloid, Amygdala, Salivary gland, Pancreatic islet, Hypothalamus, Cortex, Retina, Eye, Placenta, Spinal cord

Animal Models for Insulin Resistance or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Insulin Resistance:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.5PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, TNF
2MP:000537910.5IGF1, INSR, TNF, HSD11B1, PTPN1, PTPRF
3MP:000536710.4BSCL2, IGF1, INSR, PTPRF, FABP2, HNF1B
4MP:000539010.4IGF1, IGF1R, TNF, PTPN1, PTPRF, IRS1
5MP:000538510.4IGF1R, IGF1, BSCL2, PIK3R1, INSR, TNF
6MP:000537010.4PIK3R1, BSCL2, IGF1R, INSR, TNF, HSD11B1
7MP:000539710.4PIK3R1, BSCL2, IGF1, IGF1R, INSR, TNF
8MP:000538410.4INSR, IGF1R, IGF1, BSCL2, PIK3R1, TNF
9MP:000537510.4IGF1, IGF1R, INSR, TNF, HSD11B1, PTPN1
10MP:000538710.3TNF, INSR, IGF1R, IGF1, BSCL2, PIK3R1
11MP:000363110.3IGF1, IGF1R, INSR, TNF, HSD11B1, PTPRF
12MP:001077110.3BSCL2, IGF1, IGF1R, TNF, PTPRF, AKT2
13MP:000537810.3PPP1R3A, PIK3R1, BSCL2, IGF1, IGF1R, INSR
14MP:000538610.3TNF, INSR, IGF1R, BSCL2, HSD11B1, PTPN1
15MP:001076810.3PTPN1, TNF, INSR, IGF1R, IGF1, BSCL2
16MP:000538110.3BSCL2, IGF1R, INSR, TNF, PTPRF, SLC2A4
17MP:000200610.3AKT2, TNF, IGF1R, IGF1, PIK3R1
18MP:000537610.3AGPAT2, IGF1, IGF1R, INSR, TNF, HSD11B1
19MP:000538910.3BSCL2, IGF1, IGF1R, INSR, TNF, AKT2
20MP:000538810.2IGF1, IGF1R, INSR, TNF, HSD11B1, AKT2
21MP:000537110.0IGF1, IGF1R, TNF, IRS1, AGPAT2

Publications for Insulin Resistance

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53PubMed
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Articles related to Insulin Resistance:

(show top 50)    (show all 4999)
idTitleAuthorsYear
1
Accuracy and precision of commonly used methods for quantifying surgery-induced insulin resistance: Prospective observational study. (24257458)
2014
2
The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. (23649472)
2014
3
Correction: Overexpressing STAMP2 Improves Insulin Resistance in Diabetic ApoE(-/-)/LDLR(-/-) Mice via Macrophage Polarization Shift in Adipose Tissues. (24391692)
2013
4
The Severity of Menstrual Dysfunction as a Predictor of Insulin Resistance in PCOS. (24092831)
2013
5
Association between I^2-adrenoceptor (ADRB2) haplotypes and insulin resistance in PCOS. (22900502)
2013
6
Wrist breadth and homeostasis model assessment of insulin resistance in youth: the Fels Longitudinal Study. (23897560)
2013
7
Heat Shock Prevents Insulin Resistance Induced Vascular Complications By Augmenting Angiotensin-(1-7) Signalling. (24270982)
2013
8
Association between insulin resistance and sustained virologic response in hepatitis C treatment, genotypes 1 versus 2 and 3: systematic literature review and meta-analysis. (24055394)
2013
9
Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. (23560057)
2013
10
High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients. (22136974)
2012
11
Increased insulin resistance and C-reactive protein in women with complete hydatidiform mole. (21204606)
2011
12
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
13
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
14
Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. (20107300)
2010
15
Insulin resistance and overweight-obese women with polycystic ovary syndrome. (19903118)
2010
16
The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes. (19139803)
2009
17
Vascular insulin resistance: a potential link between cardiovascular and metabolic diseases. (19146801)
2009
18
Role of mitochondrial dysfunction in insulin resistance. (18309108)
2008
19
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. (18443205)
2008
20
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
21
The metabolic syndrome X or insulin resistance syndrome]. (17304724)
2007
22
Resistin: a hormone which induces insulin resistance is increased in normal pregnancy. (17919114)
2007
23
Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. (17582143)
2007
24
Insulin resistance and atherosclerosis. (16823479)
2006
25
Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance. (16478779)
2006
26
Association of inflammatory marker and highly sensitive C-reactive protein with aerobic exercise capacity, maximum oxygen uptake and insulin resistance in healthy middle-aged volunteers. (15791041)
2005
27
Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. (16034720)
2005
28
Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. (16182246)
2005
29
Molecular mechanisms of impaired endothelial function associated with insulin resistance. (15032648)
2004
30
Should we routinely measure a proxy for insulin resistance as well as improve our modelling techniques to better predict the likelihood of coronary heart disease in people with type 2 diabetes. (15171756)
2004
31
Inflammation, insulin resistance, and adiposity: a study of first-degree relatives of type 2 diabetic subjects. (15277436)
2004
32
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
33
Unraveling the mysteries of syndrome X. As the number of Americans with insulin resistance grows, pharmacists can help patients prevent the onset of type 2 diabetes and cardiovascular disease. (14626524)
2003
34
Relationship of insulin resistance and overweight with cortisol and dehydroepiandrosterone-sulfate levels. (12505096)
2002
35
Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia. (12145148)
2002
36
Insulin-regulated transcription factors: molecular link between insulin resistance and cardiovascular risk factors. (11466584)
2001
37
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
38
Serum leptin concentrations in young insulin-sensitive and insulin-resistant volunteers. (10965933)
2000
39
Remodeling of the endocrine pancreas: the central role of amylin and insulin resistance. (10653060)
2000
40
AlstrAPm syndrome with subclinical insulin-resistant diabetes and hepatic dysfunction: a family report. (10845422)
2000
41
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine. (10574416)
1999
42
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
43
Components of the insulin resistance syndrome are associated with progression of atherosclerosis in non-grafted arteries 5 years after coronary artery bypass surgery. (9717003)
1998
44
Cellular mechanism of nutritionally induced insulin resistance: the desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome. (10212843)
1998
45
Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. (9222647)
1997
46
Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. (9056694)
1997
47
Epidemiology of hypertension and insulin resistance syndrome. (9050982)
1997
48
Insulin resistance in insulin-dependent diabetic patients with microalbuminuria. (8105164)
1993
49
Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle. (1547918)
1992
50
Association of specific histocompatibility antigens and acanthosis nigricans with insulin resistance. (2101060)
1990

Variations for Insulin Resistance

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Insulin Resistance:

65 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Insulin Resistance:

1 (show all 16)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
3AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
4INSRNM_000208.2(INSR): c.3481G> A (p.Ala1161Thr)single nucleotide variantPathogenicrs121913139GRCh37Chr 19, 7122673: 7122673
5INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
6INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
7GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
8SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
9GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
10IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
11IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
12MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
13NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
14ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
15ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
16HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Insulin Resistance

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Insulin Resistance

Search GEO for disease gene expression data for Insulin Resistance.

Pathways for genes affiliated with Insulin Resistance

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 54QIAGEN, 55R&D Systems, 62Tocris Bioscience, 56Reactome, 13EMD Millipore, 52PharmGKB, 5Cell Signaling Technology
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Pathways related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PPP1R3A, INSR, AKT2, SLC2A4
210.4PIK3R1, INSR, PTPN1, IRS1
3
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
10.4AKT2, IRS1, PTPN1, PIK3R1
410.4TNF, IRS1, AKT2, SLC2A4
510.4IRS1, INSR, IGF1, PIK3R1
610.4IRS1, PTPN1, IGF1R, PIK3R1
710.4PIK3R1, PTPN1, IRS1, AKT2, SLC2A4
8
Show member pathways
10.4SLC2A4, IRS1, INSR, PIK3R1, PPP1R3A
9
Show member pathways
10.4PIK3R1, INSR, IRS1, AKT2, SLC2A4
1010.4AKT2, INSR, IGF1R, PIK3R1
1110.4PIK3R1, INSR, AKT2, HNF4A, SLC2A4
12
Show member pathways
10.3PIK3R1, IGF1, IGF1R, AKT2
1310.3AKT2, IGF1R, IGF1, PIK3R1
14
Show member pathways
10.3AKT2, INSR, IGF1R, PIK3R1, PPP1R3A
15
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
10.3PIK3R1, IGF1, IGF1R, TNF
16
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
10.3IGF1, IGF1R, TNF, IRS1, AKT2
17
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis61
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
18
Show member pathways
Development Ligand independent activation of ESR1 and ESR261
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
19
Show member pathways
Apoptosis and survival BAD phosphorylation61
Development Alpha 2 adrenergic receptor activation of ERK61
Chemotaxis CXCR4 signaling pathway61
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
20
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
21
Show member pathways
Signal transduction PTEN pathway61
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
22
Show member pathways
Signaling Pathways in Glioblastoma39
10.3PIK3R1, IGF1, IGF1R, IRS1, AKT2
23
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
10.3AKT2, IRS1, IGF1R, IGF1, PIK3R1
24
Show member pathways
10.3PIK3R1, IGF1, IGF1R, INSR, AKT2
2510.3PIK3R1, IGF1, IGF1R, INSR, AKT2
26
Show member pathways
Insulin Pathway39
10.3PIK3R1, INSR, PTPN1, SORBS1, IRS1, AKT2
2710.3SORBS1, PTPRF, PTPN1, INSR, IGF1R
28
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, IRS1
2910.3PIK3R1, IGF1, IGF1R, TNF, AKT2
3010.3PIK3R1, IGF1, IGF1R, TNF, AKT2
3110.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
32
Show member pathways
10.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
33
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1R, INSR, TNF, SLC2A4
3410.3BSCL2, IGF1, TNF, IRS1, SLC2A4, AGPAT2
35
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, AKT2
36
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
10.3PIK3R1, IGF1, IGF1R, SORBS1, AKT2
37
Show member pathways
10.3PIK3R1, INSR, TNF, IRS1, HNF1B, HNF4A
38
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, PTPN1
3910.3IGF1R, INSR, PTPN1, IRS1, AKT2, HNF4A
40
Show member pathways
10.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
41
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
10.3PIK3R1, IGF1, IGF1R, INSR, IRS1, AKT2
42
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
10.3PIK3R1, INSR, TNF, SORBS1, IRS1, AKT2
43
Show member pathways
10.3PIK3R1, IGF1, IGF1R, TNF, IRS1, AKT2
44
Show member pathways
10.3PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, TNF
45
Show member pathways
10.2PIK3R1, IGF1, IGF1R, INSR, TNF, IRS1
46
Show member pathways
10.2PIK3R1, IGF1, IGF1R, INSR, TNF, IRS1
47
Show member pathways
10.2PPP1R3A, PIK3R1, IGF1, IGF1R, INSR, TNF
4810.2ENPP1, AKT2, IRS1, SORBS1, PTPRF, PTPN1
49
Show member pathways
10.2PIK3R1, IGF1, IGF1R, TNF, PTPN1, PTPRF
50
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
10.1SLC2A4, PPP1R3A, AKT2, IRS1, SORBS1, PTPRF

Compounds for genes affiliated with Insulin Resistance

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Insulin Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1vanadium4610.8IRS1, SLC2A4, INSR, PTPN1
2ag 10244610.8IGF1, IRS1, INSR, IGF1R
3metformin46 52 1212.8ENPP1, IRS1, IGF1, INSR, SLC2A4, PTPN1
4pioglitazone30 46 52 1213.8TNF, INSR, HSD11B1, PTPN1, IRS1, SLC2A4
5rosiglitazone30 46 52 25 1214.7SLC2A4, IRS1, PTPN1, HSD11B1, TNF, INSR
62-deoxyglucose46 1211.7IRS1, IGF1, PPP1R3A, SLC2A4, PIK3R1, IGF1R
7sterol4610.7HSD11B1, PTPN1, PIK3R1, IRS1, HNF4A, SLC2A4
8c-peptide4610.7IGF1, IGF1R, INSR, IRS1, HNF4A
9bms 5369246210.7IGF1, IGF1R, INSR
10picropodophyllotoxin6210.7INSR, IGF1R, IGF1
11demethylasterriquinone b16210.7IGF1, IGF1R, INSR
12phosphotyrosine4610.7SLC2A4, MAPK8IP1, IRS1, PTPRF, PTPN1, INSR
13insulin (human) recombinant6210.7INSR, IGF1, IGF1R
14sb 20358046 6211.7SLC2A4, AKT2, IRS1, TNF, INSR, IGF1
15rapamycin4610.7SLC2A4, PIK3R1, AKT2, IGF1, INSR, IRS1
16okadaic acid46 6211.7PTPN1, PIK3R1, IRS1, HNF4A, SLC2A4, IGF1R
17wortmannin4610.7IGF1, IGF1R, PIK3R1, IRS1, INSR, AKT2
18pd 98,0594610.7HNF4A, IRS1, IGF1R, IGF1, INSR, TNF
19ly2940024610.7IRS1, INSR, IGF1, IGF1R, TNF, SLC2A4
20phenylalanine4610.7FABP2, IRS1, PTPN1, INSR, IGF1R, PIK3R1
21testosterone46 62 25 1213.7HNF4A, IRS1, SLC2A4, PTPN1, HSD11B1, INSR
22phosphatidylinositol4610.7IRS1, AKT2, PIK3R1, HNF4A, ENPP1, SLC2A4
23palmitate4610.7IRS1, FABP2, HNF4A, SLC2A4, INSR
24genistein46 30 62 3 25 1215.6IRS1, IGF1, PIK3R1, IGF1R, INSR, TNF
25h2o24610.6PIK3R1, SLC2A4, PTPRF, PTPN1, INSR, IGF1R
26mecasermin46 1211.6IGF1R, IGF1, INSR
27glutamine4610.6PTPN1, ENPP1, HNF4A, IGF1, IGF1R, INSR
28dexamethasone46 52 30 1213.6TNF, INSR, IGF1R, IGF1, PIK3R1, ENPP1
29glycogen46 2511.6PPP1R3A, IGF1R, INSR, HSD11B1, PTPN1, PIK3R1
30cholesterol46 30 25 1213.6HSD11B1, IGF1, IGF1R, PTPN1, FABP2, HNF1B
31estrogen4610.6PTPN1, HSD11B1, INSR, AKT2, IRS1, IGF1
32threonine4610.6HNF4A, ENPP1, MAPK8IP1, AKT2, PTPN1, PIK3R1
33ibmx46 62 3012.6SLC2A4, IRS1, INSR, IGF1R, IGF1
34alanine4610.6IGF1R, HSD11B1, INSR, IRS1, FABP2, HNF4A
35thymidine46 2511.6IGF1R, HNF4A, INSR, TNF, IRS1, PIK3R1
36lipid4610.6PPP1R3A, SLC2A4, AGPAT2, ENPP1, PIK3R1, INSR
37serine4610.6PIK3R1, IGF1R, INSR, TNF, SLC2A4, PTPN1
38glucosamine46 25 1212.6INSR, SLC2A4, TNF, IRS1
39tyrosine4610.6SLC2A4, ENPP1, PIK3R1, IGF1, AKT2, IRS1
40cycloheximide4610.5INSR, IGF1R, TNF, PIK3R1, IGF1, IRS1
41actinomycin d4610.5SLC2A4, IRS1, TNF, INSR, IGF1R, IGF1
42glycerol46 25 1212.5SLC2A4, HNF4A, INSR, IRS1, HSD11B1
43phosphoserine46 2511.5PTPN1, IRS1, IGF1R, INSR
44retinoic acid46 2511.5HNF4A, SLC2A4, IGF1R, TNF, IRS1, FABP2
45glucose4610.5SLC2A4, ENPP1, HNF4A, HNF1B, MAPK8IP1, AKT2
46phosphoenolpyruvate46 1211.5HNF4A, HSD11B1, IRS1, SLC2A4
47fatty acid4610.3FABP2, ENPP1, SLC2A4, HNF4A, IRS1, HSD11B1
48c2ceramide4610.3TNF, PIK3R1
49nitric oxide46 25 1212.3PTPN1, PIK3R1, IGF1R, SLC2A4, HNF4A, MAPK8IP1
50arginine4610.0IGF1, PTPN1, INSR, IRS1, HNF1B, HNF4A

GO Terms for genes affiliated with Insulin Resistance

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Sources:
17Gene Ontology
See all sources

Cellular components related to Insulin Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor complexGO:00589910.4IRS1, SORBS1, INSR
2integral component of plasma membraneGO:00588710.3SLC2A4, ENPP1, PTPRF, TNF, INSR, IGF1R
3plasma membraneGO:00588610.1PIK3R1, IGF1, IGF1R, INSR, TNF, PTPN1
4caveolaGO:00590110.1IGF1R, INSR, IRS1

Biological processes related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of insulin receptor signaling pathwayGO:04662710.8PTPN1, IRS1, ENPP1
2glucose homeostasisGO:04259310.8SLC2A4, HNF4A, IRS1, INSR
3exocrine pancreas developmentGO:03101710.8INSR, IGF1R, IGF1
4mammary gland developmentGO:03087910.8IGF1, IGF1R, IRS1
5positive regulation of glucose import in response to insulin stimulusGO:200127510.7AKT2, IRS1
6positive regulation of glycogen biosynthetic processGO:04572510.7IGF1, INSR, SORBS1, IRS1, AKT2
7phosphatidylinositol 3-kinase signalingGO:01406510.7PIK3R1, IGF1R, IRS1
8insulin-like growth factor receptor signaling pathwayGO:04800910.7PIK3R1, IGF1, IGF1R, IRS1
9positive regulation of mitosisGO:04584010.7TNF, INSR, IGF1
10sequestering of triglycerideGO:03073010.7ENPP1, TNF
11positive regulation of protein kinase B signalingGO:05189710.7IGF1, IGF1R, INSR, TNF
12cellular response to insulin stimulusGO:03286910.7INSR, SORBS1, IRS1, AKT2, ENPP1, SLC2A4
13positive regulation of glucose metabolic processGO:01090710.7AKT2, IRS1
14positive regulation of glucose importGO:04632610.7AKT2, IRS1, SORBS1, INSR, IGF1, PIK3R1
15positive regulation of DNA replicationGO:04574010.7IGF1, IGF1R, INSR
16positive regulation of cell migrationGO:03033510.7PIK3R1, IGF1R, INSR, IRS1
17positive regulation of fatty acid beta-oxidationGO:03200010.7IRS1, AKT2
18negative regulation of glucose importGO:04632510.7TNF, ENPP1
19phosphatidylinositol-mediated signalingGO:04801510.7IRS1, IGF1R, IGF1, PIK3R1
20positive regulation of MAPK cascadeGO:04341010.7IGF1, IGF1R, INSR
21insulin receptor signaling pathwayGO:00828610.7PIK3R1, IGF1R, INSR, PTPN1, SORBS1, IRS1
22male sex determinationGO:03023810.7INSR, IGF1R
23positive regulation of glycolytic processGO:04582110.6INSR, IGF1
24positive regulation of protein phosphorylationGO:00193410.6INSR, TNF, AKT2
25regulation of JNK cascadeGO:04632810.6MAPK8IP1, IGF1R
26negative regulation of lipid catabolic processGO:05099510.5TNF, BSCL2
27positive regulation of cytokine productionGO:00181910.5AGPAT2, TNF
28positive regulation of transcription from RNA polymerase II promoterGO:04594410.5PIK3R1, IGF1, TNF, HNF1B, HNF4A
29JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.4IRS1, PTPN1
30positive regulation of establishment of protein localization to plasma membraneGO:09000410.4PIK3R1, SORBS1
31positive regulation of cell proliferationGO:00828410.3IRS1, INSR, IGF1R, IGF1
32blood coagulationGO:00759610.1PIK3R1, IGF1, PTPN1, HNF4A

Molecular functions related to Insulin Resistance according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.5IRS1, INSR, IGF1, PIK3R1
2phosphatidylinositol 3-kinase bindingGO:04354810.5PIK3R1, IGF1R, INSR, IRS1
3insulin bindingGO:04355910.5INSR, IGF1R, PIK3R1
4insulin receptor bindingGO:00515810.5ENPP1, PIK3R1, IGF1, IGF1R, PTPN1, SORBS1
5fatty acid bindingGO:00550410.4HNF4A, FABP2
6insulin receptor substrate bindingGO:04356010.4PIK3R1, IGF1R, INSR
7insulin-like growth factor I bindingGO:03199410.3INSR, IGF1R
8protein bindingGO:00551510.2PTPN1, TNF, INSR, IGF1R, IGF1, PIK3R1
9transmembrane receptor protein tyrosine kinase adaptor activityGO:00506810.1IRS1, PIK3R1

Products for genes affiliated with Insulin Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Insulin Resistance

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet