MCID: INS001
MIFTS: 59

Insulinoma malady

Gastrointestinal, Endocrine, Cancer categories

Summaries for Insulinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 An insulinoma is a tumor of the pancreas that is derived from beta cells and secretes insulin. more...

MalaCards: Insulinoma, also known as islet cell adenoma, is related to hypoglycemia and multiple endocrine neoplasia. An important gene associated with Insulinoma is ITS (Insulinoma tumor suppressor gene locus), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The compounds glucose and calcium have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lymph node, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Disease Ontology:8 An adenoma that is a tumor in the pancreas that produces too much insulin.

Aliases & Classifications for Insulinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal, Endocrine


Aliases & Descriptions:

insulinoma 8 43 47 10 45 49 61
islet cell adenoma 8 61
insulin-producing tumor of islet cells 8
adenoma islet cell 45
insulinoma nos 8
insuloma 49


External Ids:

Disease Ontology8 DOID:3892
NCIt40 C3140
MeSH35 D007340
ICD10 via Orphanet26 E16.8
MESH via Orphanet36 D007340
SNOMED-CT via Orphanet58 25324008, 302822000
UMLS via Orphanet62 C0021670

Related Diseases for Insulinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Insulinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia31.0GLP1R, GCK, IAPP, SCT, SST
2multiple endocrine neoplasia30.8MEN1
3glucagonoma30.6SCT, MEN1, SSTR5, SST
4gastrinoma30.5GLP1R, SST, IAPP, MEN1, SCT, CASR
5insulin resistance30.4GCK, PAX4, IAPP, GLP1R, SST
6hyperinsulinism30.3IAPP, GCK, SCT, SST, GLP1R, PAX4
7hyperinsulinemic hypoglycemia30.3SCT, SST
8pheochromocytoma30.2MEN1, SCT, IAPP, SST, SSTR4, SSTR5
9adenoma30.2GIPR, SSTR5, SSTR4, MEN1, CASR, SCT
10hypercalcemia30.0SCT, MEN1, IAPP, CASR
11zollinger-ellison syndrome30.0SST, MEN1, SCT
12primary hyperparathyroidism30.0SCT, MEN1, CASR
13pancreatic islet cell tumors29.8MEN1, SST, IAPP
14glucose intolerance29.8GLP1R, IAPP, GCK
15pancreatitis, chronic29.8SST, SCT, CASR
16dumping syndrome29.8SST
17metastatic insulinoma10.7
18somatostatin analog10.3
19seizure disorder10.2
20n syndrome10.2
21fasting hypoglycemia10.2
22gastroduodenitis10.2
23hypokalemia10.2
24wdha syndrome10.2
25sdha-related hereditary paraganglioma-pheochromocytoma syndrome10.2
26neurofibromatosis10.0
27duodenal ulcer10.0
28adult syndrome10.0
29adenocarcinoma10.0
30familial hypocalciuric hypercalcemia10.0
31adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia10.0
32diabetes mellitus10.0PTPRN, GCK, CASR, PAX4, INSM2, GLP1R
33hyperglycemia10.0PTPRN, SST, IAPP, GCK, PAX4, SCT
34type 1 diabetes10.0PTPRN, PAX4, IAPP, WFS1, SCT, GCK
35carcinoid syndrome10.0SCT, MEN1, IAPP, SSTR5, SST, GLP1R
36type 2 diabetes mellitus10.0PTPRN, PAX4, SCT, IAPP, GLP1R, GCK
37pituitary tumors10.0SSTR4, SST, SSTR5, MEN1, INSM1
38thyroid medullary carcinoma10.0CASR, MEN1, IAPP, SSTR5, SST
39neuroendocrine tumor10.0MEN1, SST, GLP1R, SCT, INSM1
40pituitary adenoma10.0SST, CASR, MEN1, SSTR5
41prolactinoma10.0SST, SSTR4, SSTR5, MEN1
42pancreatitis10.0CASR, SCT, SST
43hyperparathyroidism10.0CASR, SCT, MEN1
44obesity10.0GLP1R, GCK, IAPP
45vipoma10.0SCT, SST, MEN1
46atrophic gastritis10.0MEN1, SCT, SST
47acromegaly10.0SST, MEN1, SSTR5
48lung small cell carcinoma10.0SCT, MEN1, INSM1, SST
49maturity-onset diabetes of the young10.0PAX4, GCK
50gestational diabetes10.0IAPP, GCK, PTPRN

Graphical network of the top 20 diseases related to Insulinoma:



Diseases related to insulinoma

Clinical Features for Insulinoma

Drugs & Therapeutics for Insulinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Insulinoma

Drug clinical trials:

Search ClinicalTrials for Insulinoma

Search NIH Clinical Center for Insulinoma

Search CenterWatch for Insulinoma

Genetic Tests for Insulinoma

Anatomical Context for Insulinoma

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Insulinoma:

33
Liver, Brain, Lymph node, Lung, Spleen, Whole blood, Retina, Pancreas, T cells, B cells, Temporal lobe, Hypothalamus, Appendix, Pancreatic islet, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Insulinoma:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease

Animal Models for Insulinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Insulinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3PTPRN, KCNA5, GCK, CASR, SCT, MEN1
2MP:000537811.0CASR, MEN1, WFS1, IAPP, SSTR5, SST
3MP:000537910.8GCK, CASR, MEN1, WFS1, SSTR5, MAFA

Publications for Insulinoma

Sources:
51PubMed
See all sources

Articles related to Insulinoma:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
Scaffold Architecture Controls Insulinoma Clustering, Viability and Insulin Production. (24410263)
2014
2
Insulinoma of genetic aetiology. (23769271)
2013
3
Thioredoxin-mimetic peptides (TXM) reverse auranofin induced apoptosis and restore insulin secretion in insulinoma cells. (23327993)
2013
4
Prospective evaluation of biweekly streptozotocin in 19 dogs with insulinoma. (23600734)
2013
5
Reduced expression of the LRP16 gene in mouse insulinoma (MIN6) cells exerts multiple effects on insulin content, proliferation and apoptosis. (22528219)
2012
6
Effective therapy of insulinoma by using long-acting somatostatin analogue. A case report and literature review. (22187292)
2012
7
Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents. (23213352)
2012
8
Associations of ATP-binding cassette transporter A1 and G1 with insulin secretion in human insulinomas. (22466164)
2012
9
Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. (21734072)
2011
10
Pregnenolone sulfate activates basic region leucine zipper transcription factors in insulinoma cells: role of voltage-gated Ca2+ channels and transient receptor potential melastatin 3 channels. (21948387)
2011
11
Enucleation of an Insulinoma of the Pancreas Using Reduced Port Surgery: Report of a Case. (22504977)
2011
12
Insulinoma presenting as postprandial hypoglycaemia. (22678942)
2011
13
The gene encoding cyclooxygenase-2 is regulated by IL-1I^ and prostaglandins in 832/13 rat insulinoma cells. (21885043)
2011
14
Nanomechanical analysis of insulinoma cells after glucose and capsaicin stimulation using atomic force microscopy. (21623392)
2011
15
Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1. (21265734)
2011
16
Metabolic acidosis as a complication of intravenous dextrose administration in a patient with insulinoma. (20972720)
2010
17
A case of insulinoma following total gastrectomy--effects of an alpha-glucosidase inhibitor on suppressing GIP and GLP-1 elevations. (20122751)
2010
18
Association between insulinoma and adrenal insufficiency: a case report and review of the literature. (20418760)
2010
19
Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. (20829364)
2010
20
Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. (20033320)
2010
21
Increased EpCAM expression in malignant insulinoma: potential clinical implications. (20097833)
2010
22
Rare case of insulinoma diagnosed after laparoscopic gastric banding. (18539089)
2009
23
Peritoneal dialysis masking symptoms of an insulinoma uncovered during the perioperative period: a case report. (19139696)
2009
24
Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma. (18430790)
2008
25
Insulinoma presenting itself as a night paroxysmal disorder with spontaneous recovery. (18592970)
2008
26
Can insulinoma cause generalised epilepsy? (17849747)
2007
27
Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome. (16555022)
2006
28
The management of insulinoma. (16498592)
2006
29
Insulinoma: Diagnosis and surgical treatment. Retrospective analysis of 31 cases. (17090842)
2006
30
Insulinoma in Iran: a 20-year review. (16438457)
2005
31
Insulinoma in 2 guinea pigs (Cavia porcellus). (15943120)
2005
32
Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma. (15365726)
2004
33
FADDdel-GFP modified mouse insulinoma cells counteract the cytotoxicity of reactive T cells. (16285899)
2004
34
Gene expression profiling in human insulinoma tissue: genes involved in the insulin secretion pathway and cloning of novel full-length cDNAs. (15163304)
2004
35
An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures. (12941771)
2003
36
Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. (10871193)
2000
37
Clinical presentation of PCOS following development of an insulinoma: case report. (10611194)
2000
38
Role of hepatic arterial embolisation in the treatment for metastatic insulinoma. Report of two cases and review of the literature. (9489120)
1997
39
Insulinoma. Clinical and surgical considerations concerning a case]. (9148220)
1997
40
Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma. (8813473)
1996
41
Treatment of metastatic malignant insulinomas. 2 cases]. (7638129)
1995
42
Regulation of insulinoma cell proliferation and insulin accumulation by peptides and second messengers. (8808183)
1995
43
Cytological pattern of multihormonal carcinoid of the appendix with metastasis to the liver corresponding a clinical insulinoma. (7953441)
1994
44
GLUT2 surface expression and intracellular transport via the constitutive pathway in pancreatic beta cells and insulinoma: evidence for a block in trans-Golgi network exit by brefeldin A. (8276890)
1993
45
Insulinoma in pregnancy presenting as a seizure disorder: a case report. (1505386)
1992
46
Use of the glucose clamp technique for confirmation of insulinoma autonomous hyperinsulinism. (3034180)
1987
47
Surgical treatment of organic hyperinsulinism in infancy. Surgical procedure in the absence of a demonstrable insulinoma and a peroperative diagnosis of nesidioblastosis. (6328789)
1984
48
An insulinoma without fasting hypoglycemia. (188337)
1976
49
Notes on streptozotocin in metastatic insulinoma. (4329781)
1971
50
Streptozotocin for metastatic insulinoma. (4319193)
1970

Genetic Variations for Insulinoma

Expression for genes affiliated with Insulinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Insulinoma

Search GEO for disease gene expression data for Insulinoma.

Pathways for genes affiliated with Insulinoma

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Insulinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Insulinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1glucose4511.5PAX4, GLP1R, SST, IAPP, SCT, CASR
2calcium45 50 11 2414.3MEN1, WFS1, GLP1R, SCT, KCNA5, SSTR5
3c-peptide4511.3GLP1R, SST, IAPP, SCT, GCK, PTPRN
4adenylate4511.3SCT, GLP1R, CASR, SST, IAPP, GCK
5acth4511.2GIPR, SST, SCT, CASR, SSTR5
6potassium45 11 2413.2CASR, SCT, KCNA5, GLP1R, GCK
7octreotide45 60 29 1114.2SCT, SSTR5, SSTR4, SST
8arginine4511.1GCK, SST, SCT, PTPRN, CASR, IAPP
9cyn 1548066011.1SST, SSTR5, SSTR4
10cyclosomatostatin6011.1SSTR5, SST, SSTR4
11(1r,1s,3r/1r,1r,3s)-l-054,2646011.1SST, SSTR4, SSTR5
12somatostatin60 2412.1SSTR5, SSTR4, SST
13incretin4511.1GCK, GLP1R, IAPP
14oxyntomodulin45 6012.1SST, SCT, GLP1R
15lanreotide45 2912.1SSTR4, SST, SSTR5
16sulfonylurea4511.1GLP1R, IAPP, GCK
17[125i]tyr11-srif-142911.0SSTR4, SSTR5
18prl-29152911.0SSTR4, SSTR5
19des-aa5-[d-trp8]srif2911.0SSTR5, SSTR4
20srif-282911.0SSTR5, SSTR4
21[125i]ltt-srif-282911.0SSTR4, SSTR5
22srif-142911.0SSTR5, SSTR4
23[125i]tyr10-cst142911.0SSTR5, SSTR4
24pasireotide45 1112.0SSTR5, SST
25[d-tyr8]cyn 1548062911.0SSTR5, SSTR4
26[l-tyr8]cyn 1548062911.0SSTR5, SSTR4
27streptozotocin4511.0SST, GCK, IAPP
28bim 236272911.0SSTR5, SSTR4
29bim 230522911.0SSTR4, SSTR5
30cgp 239962911.0SSTR5, SSTR4
31ke 1082910.9SSTR4, SSTR5
32l-362,8552910.9SSTR4, SSTR5
33[125i]cgp 239962910.9SSTR5, SSTR4
34bim 234542910.9SSTR5, SSTR4
35cst-172910.9SSTR4, SSTR5
36taurodeoxycholate4510.9SCT, SST
37cst-142910.9SSTR5, SSTR4
38glp-1 (7-36)amide4510.9GLP1R, SCT
39metformin45 50 1112.9IAPP, GCK, GLP1R
40lafutidine4510.9SST, SCT
41liraglutide45 29 1112.8IAPP, GLP1R
42exenatide45 1111.8IAPP, GLP1R
43loxiglumide4510.8SST, SCT
44vapreotide29 45 1112.7SSTR5, SST
45ribonucleic acid4510.7GIPR, SSTR4, SSTR5, CASR
46111in-pentetreotide4510.7SSTR5, SST
47sitagliptin45 1111.7IAPP, GLP1R
48proglucagon4510.6GCK, GLP1R
49i-app4510.5IAPP, GCK
50repaglinide45 50 1112.3PAX4, IAPP

GO Terms for genes affiliated with Insulinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Insulinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1endocrine pancreas developmentGO:03101811.0PAX4, INSM1, GIPR, IAPP, GCK
2regulation of insulin secretionGO:05079610.9KCNA5, GCK, SSTR5, GLP1R
3response to glucose stimulusGO:00974910.8PTPRN, GIPR, MAFA
4regulation of potassium ion transportGO:04326610.7GCK, KCNA5
5glucose homeostasisGO:04259310.7GCK, WFS1, SSTR5
6negative regulation of cell proliferationGO:00828510.7SST, SSTR4, SSTR5, MEN1
7elevation of cytosolic calcium ion concentrationGO:00720410.7GLP1R, GIPR, GCK
8G-protein coupled receptor signaling pathwayGO:00718610.6CASR, SSTR5, SSTR4, SST
9calcium ion importGO:07050910.3CASR, GCK

Molecular functions related to Insulinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7SST, IAPP, SCT
2somatostatin receptor activityGO:00499410.3SSTR4, SSTR5

Products for genes affiliated with Insulinoma

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  • Lysates
  • Antibodies

Sources for Insulinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet