MCID: INS001
MIFTS: 59

Insulinoma malady

Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Insulinoma

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Wikipedia:65 An insulinoma is a tumor of the pancreas that is derived from beta cells and secretes insulin. It is a... more...

MalaCards based summary: Insulinoma, also known as insulin-producing tumor of islet cells, is related to glucagonoma and hypoglycemia. An important gene associated with Insulinoma is ITS (Insulinoma tumor suppressor gene locus), and among its related pathways are Selected targets of HNF1 and G alpha (s) signalling events. The compounds repaglinide and secretoneurin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and pancreatic islet, and related mouse phenotypes are growth/size/body and endocrine/exocrine gland.

Disease Ontology:8 An adenoma that is a tumor in the pancreas that produces too much insulin.

Aliases & Classifications for Insulinoma

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Insulinoma, Aliases & Descriptions:

Name: Insulinoma 30 8 42 46 10 44 48 62
Insulin-Producing Tumor of Islet Cells 8 62
Islet Cell Adenoma 8 62
 
Adenoma Islet Cell 44
Insuloma 48


Classifications:



External Ids:

Disease Ontology8 DOID:3892
NCIt39 C3140
MeSH34 D007340
MESH via Orphanet35 D007340
ICD10 via Orphanet26 E16.8
UMLS via Orphanet63 C0021670

Related Diseases for Insulinoma

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Diseases related to Insulinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1glucagonoma30.9SSTR5, SCT
2hypoglycemia30.7SCT, IAPP, GCK, SLC2A2
3gastrinoma30.4SCT, IAPP, SSTR5, CASR
4primary hyperparathyroidism30.4CASR, SCT
5hyperparathyroidism30.4SCT, CASR
6hypercalcemia30.3CASR, IAPP, SCT
7neuroendocrine tumor30.3INSM1, SCT, SCG2
8hyperinsulinism30.3GCK, IAPP, PAX4, SCT
9insulin resistance30.1GCK, IAPP, PAX4
10pheochromocytoma30.0SCT, SCG2, IAPP, SSTR5
11type 2 diabetes mellitus29.8SCT, PAX4, IAPP, GCK, SLC2A2
12pituitary adenoma29.8CASR, SSTR5, SCG2
13glucose intolerance29.7SLC2A2, GCK, IAPP
14adenocarcinoma29.6CASR, IAPP, SCG2, SCT
15diabetes mellitus29.3SCT, PAX4, GIPR, IAPP, WFS1, CASR
16adenoma29.3SCT, SCG2, GIPR, SSTR5, CASR
17hyperglycemia29.2SLC2A2, GCK, IAPP, PAX4, SCT
18pancreatitis10.8
19metastatic insulinoma10.7
20multiple endocrine neoplasia10.6
21hepatitis10.5
22osteomalacia10.4CASR
23obesity10.3
24duodenitis10.3
25seizure disorder10.3
26hyperinsulinemic hypoglycemia10.3
27fasting hypoglycemia10.2
28somatostatin analog10.2
29wermer syndrome10.2SCT, CASR
30hypokalemia10.2
31gastroduodenitis10.2
32diarrhea10.2
33hereditary paraganglioma-pheochromocytoma syndromes10.2
34pancreatic adenoma10.2
35wdha syndrome10.2
36islet cell tumor10.2
37primary hyperoxaluria10.1SCT, IAPP, CASR
38gestational diabetes10.1GCK, IAPP
39maturity-onset diabetes of the young10.1GCK, PAX4
40thyroid medullary carcinoma10.1IAPP, SSTR5, CASR
41hypertension10.1
42pancreatic cancer10.1
43duodenal ulcer10.1
44zollinger-ellison syndrome10.1
45acanthosis nigricans10.1
46neuropathy10.1
47familial hypocalciuric hypercalcemia10.1
48adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia10.1
49neonatal diabetes mellitus10.0SLC2A2, GCK
50lung small cell carcinoma10.0INSM1, SCT, SCG2

Graphical network of the top 20 diseases related to Insulinoma:



Diseases related to insulinoma

Symptoms for Insulinoma

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Drugs & Therapeutics for Insulinoma

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Drug clinical trials:

Search ClinicalTrials for Insulinoma

Search NIH Clinical Center for Insulinoma

Genetic Tests for Insulinoma

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Anatomical Context for Insulinoma

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MalaCards organs/tissues related to Insulinoma:

32
Pancreas, Testes, Pancreatic islet, Liver, T cells, Spleen, Pituitary, Brain, B cells, Bone, Lymph node, Retina, Lung, Hypothalamus, Temporal lobe

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Insulinoma:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease

Animal Models for Insulinoma or affiliated genes

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MGI Mouse Phenotypes related to Insulinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.3IAPP, SSTR5, WFS1, CASR, GCK, SLC2A2
2MP:00053796.5SLC2A2, INSM1, PAX4, GIPR, SSTR5, WFS1
3MP:00053765.8KCNA5, INSM1, SCT, GIPR, IAPP, SSTR5

Publications for Insulinoma

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Articles related to Insulinoma:

(show top 50)    (show all 763)
idTitleAuthorsYear
1
mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells. (25370781)
2014
2
Somatostatin analog inhibits the growth of insulinoma cells by p27-mediated G1 cell cycle arrest. (24694834)
2014
3
Insulinoma presenting with long-standing depression, primary hypogonadism, and sertoli cell only syndrome. (24455334)
2013
4
Canine insulinoma as a model for studying molecular genetics of tumorigenesis and metastasis. (23707578)
2013
5
An insulinoma presenting with hypochondriac delusions and food refusal. (23835036)
2013
6
Giant pancreatic insulinoma. The bigger the worse? Report of two cases and literature review. (23333851)
2013
7
Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. (22155656)
2012
8
Management of insulinoma: Tunisians' experience. (22695091)
2012
9
Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. (21734072)
2011
10
Pregnenolone sulfate activates basic region leucine zipper transcription factors in insulinoma cells: role of voltage-gated Ca2+ channels and transient receptor potential melastatin 3 channels. (21948387)
2011
11
Successful laparoscope resection of ectopic insulinoma in duodenohepatic ligament. (21358311)
2011
12
Metabolic acidosis as a complication of intravenous dextrose administration in a patient with insulinoma. (20972720)
2010
13
Clinical profile of insulinoma: analysis from a tertiary care referral center in India. (20953750)
2010
14
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. (20555035)
2010
15
Insulinoma and squamous cell carcinoma with peripheral polyneuropathy in an aged Sprague-Dawley rat. (21205453)
2010
16
Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. (18783846)
2009
17
Localization of insulinoma associated protein 2, IA-2 in mouse neuroendocrine tissues using two novel monoclonal antibodies. (19233214)
2009
18
A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2. (18535195)
2008
19
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. (18252785)
2008
20
Re: "Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome". (17171485)
2007
21
Karyotype of the human insulinoma CM cell line--beta cell model in vitro? (17492774)
2007
22
Crystal structure of the major diabetes autoantigen insulinoma-associated protein 2 reveals distinctive immune epitopes. (17192463)
2007
23
Rapid intraoperative insulin assay: a novel method to differentiate insulinoma from nesidioblastosis in the pediatric patient. (17958895)
2007
24
The role of intra-arterial calcium stimulation test with hepatic venous sampling (IACS) in the management of occult insulinomas. (17431724)
2007
25
The insulinoma-associated 1: a novel promoter for targeted cancer gene therapy for small-cell lung cancer. (16052225)
2006
26
Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome. (16555022)
2006
27
Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells. (16150114)
2005
28
Effect of PK11195, a peripheral benzodiazepine receptor agonist, on insulinoma cell death and insulin secretion. (15909116)
2005
29
Malignant insulinoma in ectopic pancreatic tissue. (16432300)
2005
30
Insulinoma in Iran: a 20-year review. (16438457)
2005
31
The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5. (16263117)
2005
32
Insulin determination by specific and unspecific immunoassays in patients with insulinoma evaluated by the arterial stimulation and venous sampling test. (15248832)
2004
33
The diagnosis and treatment of insulinoma and gastrinoma]. (15045936)
2004
34
Locating an insulinoma by surgical exploration. (15524227)
2004
35
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. (12941803)
2003
36
Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells. (12475794)
2002
37
An insulinoma for which secretin test and selective arterial calcium injection test were useful. (12413006)
2002
38
A novel insulinoma tumor suppressor gene locus on chromosome 22q with potential prognostic implications. (11739439)
2001
39
Proteins spontaneously released by rat insulinoma (RIN) cells are anchored on cell membrane by a glycosyl-phosphatidyl-inositol link and inhibit increased RIN cell adhesion of lymphocytes from type 1 diabetic patients and non-obese diabetic mice in vitro. (8985653)
1996
40
Correlations of plasma concentrations of B-cell polypeptides with pathologic features of insulinomas. (15251555)
1996
41
Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress. (7672482)
1995
42
HLA-DR-restricted T cell lines from newly diagnosed type 1 diabetic patients specific for insulinoma and normal islet beta cell proteins: lack of reactivity to glutamic acid decarboxylase. (7554382)
1995
43
Intracellular degradation of the C-peptide of proinsulin, in a human insulinoma: identification of sites of cleavage and evidence for a role for cathepsin B. (7716141)
1995
44
Expression, intracellular localization, and gene transcription regulation of the secretory protein 7B2 in endocrine pancreatic cell lines and human insulinomas. (7517367)
1994
45
Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes. (8112494)
1994
46
GLUT2 surface expression and intracellular transport via the constitutive pathway in pancreatic beta cells and insulinoma: evidence for a block in trans-Golgi network exit by brefeldin A. (8276890)
1993
47
Control of plasma glucose with somatostatin analogue (SMS 201-995) during surgical removal of insulinomas. (8121865)
1993
48
Unresponsiveness of insulinoma cells to secretin: significance of the secretin test in patients with insulinoma. (2166285)
1990
49
Forced diuresis to reduce nephrotoxicity of streptozotocin in the treatment of advanced metastatic insulinoma. (3034373)
1987
50
Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin. (4358644)
1974

Variations for Insulinoma

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Expression for genes affiliated with Insulinoma

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Expression patterns in normal tissues for genes affiliated with Insulinoma

Search GEO for disease gene expression data for Insulinoma.

Pathways for genes affiliated with Insulinoma

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Pathways related to Insulinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SLC2A2, IAPP
29.5IAPP, GIPR, SCT
3
Show member pathways
9.5SCT, GIPR, IAPP
49.0SLC2A2, GCK
5
Show member pathways
9.0SLC2A2, GCK
6
Show member pathways
8.7SCT, GIPR, IAPP, SSTR5, CASR
7
Show member pathways
7.9INSM1, PAX4, IAPP, GCK, SLC2A2
8
Show member pathways
7.9SLC2A2, GCK, IAPP, PAX4, INSM1

Compounds for genes affiliated with Insulinoma

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Compounds related to Insulinoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1repaglinide50 44 1112.0PAX4, IAPP
2secretoneurin4410.0SCT, SCG2
3i-app449.7GCK, IAPP
4ibmx44 61 2811.5SCT, IAPP, SLC2A2
5norepinephrine44 24 1111.4IAPP, SCG2, SCT
6alloxan449.4SLC2A2, GCK
73-o-methylglucose449.4GCK, SLC2A2
8preproinsulin449.4GCK, SLC2A2
9ribonucleic acid449.4CASR, SSTR5, GIPR
10histamine44 28 2411.3SCT, SCG2, IAPP
11acth449.3SCT, GIPR, SSTR5, CASR
12cyclic amp44 2410.3CASR, IAPP, SCG2, SCT
13proglucagon449.3SLC2A2, GCK
14incretin449.2SLC2A2, GCK, IAPP
15katp449.2SLC2A2, GCK
16sulfonylurea449.2SLC2A2, GCK, IAPP
17dopamine44 28 24 1112.2SSTR5, IAPP, SCG2, SCT
18streptozotocin449.2IAPP, GCK, SLC2A2
19acetylcholine44 50 28 24 1113.1IAPP, SCG2, SCT
20fructose44 1110.0SLC2A2, GCK
21mannitol44 1110.0SLC2A2, GCK, SCT
22c-peptide448.8SCT, IAPP, GCK, SLC2A2
23h2o2448.7KCNA5, IAPP, GCK, SLC2A2
24hydrogen44 249.6SCT, CASR, GCK, SLC2A2
25adenylate448.6GCK, CASR, IAPP, SCG2, SCT
26oligonucleotide448.5SCT, IAPP, GCK, SLC2A2
27cysteine448.5SCT, SCG2, IAPP, CASR, GCK
28arginine448.4SLC2A2, GCK, CASR, IAPP, SCT
29potassium44 24 1110.4KCNA5, SCT, CASR, GCK, SLC2A2
30atp44 289.2SLC2A2, GCK, IAPP, SCG2, SCT
31forskolin44 50 1110.0SLC2A2, GCK, CASR, IAPP, SCG2, SCT
32glucose447.6SCT, SCG2, PAX4, IAPP, CASR, GCK
33calcium44 50 24 1110.5KCNA5, SCT, SCG2, IAPP, SSTR5, WFS1

GO Terms for genes affiliated with Insulinoma

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Biological processes related to Insulinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of potassium ion transportGO:0432669.5KCNA5, GCK
2positive regulation of cell differentiationGO:0455979.4INSM1, PAX4
3calcium ion importGO:0705099.3GCK, CASR
4hexose transportGO:0086459.0SLC2A2, GCK
5positive regulation of insulin secretionGO:0320249.0GCK, GIPR
6glucose homeostasisGO:0425938.9GCK, WFS1, SSTR5
7regulation of insulin secretionGO:0507968.4SLC2A2, GCK, SSTR5, KCNA5
8endocrine pancreas developmentGO:0310187.7SLC2A2, INSM1, PAX4, GIPR, IAPP, GCK

Products for genes affiliated with Insulinoma

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Sources for Insulinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet