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MCID: INS001

Insulinoma malady
18 drugs, 201 genes, 9 tissues, 1450 related diseases, 29 phenotypes, 257 articles, clinical trials.

Summaries for Insulinoma

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Wikipedia: An insulinoma is a tumor of the pancreas that is derived from beta cells and secretes insulin.44 more...

MalaCards: Insulinoma, also known as islet cell adenoma, is related to thyroid cancer and endocrine gland cancer. An important gene associated with Insulinoma is IAPP (islet amyloid polypeptide), and among its related pathways are Maturity onset diabetes of the young and Type II diabetes mellitus. The drugs dexamethasone and prednisone and the compounds glucose and histidine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, liver and pancreas, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: An adenoma that is a tumor in the pancreas that produces too much insulin.6

Aliases & Descriptions for Insulinoma

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6Disease Ontology, 7diseasecard, 30NIH Rare Diseases, 8DISEASES, 33OMIM, 32Novoseek , 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH
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Aliases & Descriptions:

insulinoma 6 7 30 8 33 32 43
islet cell adenoma 6 43
islet cell adenoma (morphologic abnormality) 6
insulinoma nos (morphologic abnormality) 6
insulin-producing tumor of islet cells 6
insulinoma (morphologic abnormality) 6
insulinoma (disorder) 6
neoplasms 43

Related Diseases for Insulinoma

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13GeneCards, 14GeneDecks
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Diseases related to insulinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1447)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer31.5CALCA, KRT19, PRKCA, NME1, ADCY10
2endocrine gland cancer31.5GCG, VIP, CHGA, MLH1, IAPP, SST
3multiple endocrine neoplasia30.8GCG, VIP, BRCA1, PBX1, SDHB, SDHD
4obesity30.8PCSK1, UCP1, UCP2, GHRL
5gastrinoma30.7GCG, VIP, SCT, CHGA, INS, MEN1
6parathyroid carcinoma30.7RB1, MEN1, CASR, CXADR
7hyperinsulinemic hypoglycemia30.6SCT, CHGA, INS, IGF2, SST, ABCC8
8neuroendocrine tumor30.6GCG, VIP, SDHD, SCG2, SCGN, SCT
9hyperproinsulinemia30.5PCSK2, PCSK1, SCT, INS, CPE
10nasopharynx carcinoma30.5SDHD, KCNA4, CDK4, CYCS, SMAD4, EGFR
11hypoglycemia30.3PIK3CG, PC, PCSK1, GCK, GCG, KCNJ11
12hypocalciuric hypercalcemia30.1CASR, CALCA, CXADR, GAST
13glucagonoma30.0PCSK2, PCSK1, GCG, VIP, SCG5, SCT
14ovarian mucinous neoplasm29.6RB1, MYC, CHGA, CDKN1A, MLH1, IL1B
15hypoglycemia of infancy29.3GCK, KCNJ11, KCNJ5, INS, IGF2, GLUD1
16somatostatinoma29.2GCG, VIP, CHGA, MEN1, CALCA, GIP
17pancreatic cancer29.1GCG, VIP, SCT, CHGA, CEL, CDKN1A
18primary hyperparathyroidism29.1PBX1, SCT, CHGA, MEN1, CASR, CALCA
19lipoma29.0UCP1, CDK4, INS, MEN1, GHR, TNF
20persistent hyperinsulinemic hypoglycemia of infancy29.0GCK, KCNJ11, GLUD1, ABCC8
21glucose intolerance28.9GCK, GCG, KCNJ11, LEPR, UCP2, UCP3
22brain cancer28.9PIK3CG, GCG, RB1, CGB5, CDKN1A, CDK4
23thyrotoxicosis28.8SDHB, INS, IL11, CALCA, GH1, GHRL
24pancreatic endocrine carcinoma28.6CALCA, SST, SSTR2, SSTR5, SMAD4, EGFR
25myelodysplastic syndrome28.5LEPR, XIAP, IL11, IL1A, CASP1, NF1
26craniopharyngioma28.4INS, IL1A, IGF1, CALCA, GH1, GHRL
27hematologic cancer28.3XIAP, CDKN1B, MLH1, IL11, CYCS, EGR1
28neurofibromatosis28.2SDHB, SDHD, MLH1, MEN1, GHR, SST
29testicular cancer28.2CGB5, CDKN1A, CDKN1B, IGF1, CASR, GH1
30zollinger-ellison syndrome28.0SCT, CHGA, MEN1, GRP, GHRH, SST
31breast cancer27.9BRCA1, MYC, CDKN1B, CDK4, AKT1, ESR2
32acanthosis nigricans27.9INS, INSR, IGF1, GH1, TGFA, SLC2A1
33squamous cell carcinoma27.9KRT19, EGF, EGFR, TGFA, NME1, EPCAM
34pancreatic endocrine tumors27.7PCSK2, PCSK1, GCG, VIP, CHGA, CDKN1B
35pituitary tumor27.7PCSK2, PCSK1, RB1, VIP, PBX1, SCG5
36paraganglioma27.7VIP, SDHB, SDHD, SCG2, CHGA, B3GAT1
37non-hodgkin lymphoma27.2MYC, XIAP, CDKN1B, CDKN3, INSR, IL15
38pancreatic islet cell tumors27.2VIP, CHGA, INS, MEN1, IGF2, IAPP
39hyperandrogenism27.1CGB5, INS, INSR, IGF2, IGF1, GH1
40neuroendocrine carcinoma27.0GCG, SCG2, CHGA, MEN1, GRP, CALCA
41liver cancer26.9PIK3CG, REG3A, RB1, SERPINA1, MYC, XIAP
42smooth muscle tumor26.9RB1, CDKN1A, IGF2, AKT1, CR2, NME1
43lung benign neoplasm26.9PIK3CG, RB1, CHGA, CDK4, INSM1, GSR
44pancreatic ductal carcinoma26.8PIK3CG, IL1B, NTS, PDIA3, EGF, EGFR
45pancreatic ductal adenocarcinoma26.7REG3A, MYC, CHGA, CDKN1A, MLH1, MEN1
46insulin resistance26.6PIK3CG, PCSK1, GCK, GCG, PBX1, PAX4
47skin cancer26.6BRCA1, P2RY4, CDKN3, CDK4, FOS, MAPK1
48type 2 diabetes mellitus26.5GCK, GCG, PBX1, PAX4, SDHB, KCNJ11
49gastrointestinal stromal tumor26.5PIK3CG, SDHB, SDHD, CDKN1A, MLH1, MAPK1
50peptic ulcer26.5GCG, SCT, CDKN3, GSR, MEN1, GRP

Graphical network of the top 20 diseases related to insulinoma:



Graphical network of diseases related to insulinoma

Clinical Features for Insulinoma

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Drugs & Therapeutics for Insulinoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for insulinoma

Inferred drug relations via UMLS/NDF-RT:

43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

Genetic Tests for Insulinoma

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Anatomical Context for Insulinoma

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21LifeMap Discovery™, 22MalaCards
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MalaCards organs/tissues related to insulinoma:

22
Whole blood, Liver, Pancreas, T cells, B cells, Appendix, Pancreatic islet, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to insulinoma:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Pancreas -> Islets of Langerhans -> Mature Beta Cells Affected by disease

Phenotypes for genes affiliated with Insulinoma

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25MGI
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MGI Mouse Phenotypes related to insulinoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.6BRCA1, RAB3A, SCG5, LEPR, UCP2, P2RY6
2endocrine/exocrine gland phenotypeMP:000537910.5PCSK2, PCSK1, BRCA1, VAMP2, KCNJ11, KCNJ6
3craniofacial phenotypeMP:000538210.3PBX1, KCNH2, ARNT, INSM1, MEN1, HMX1
4other phenotypeMP:00053959.9PBX1, LEPR, IDE, CASR, ESR2, CTSB
5taste/olfaction phenotypeMP:00053949.8INSM1, FFAR1, MAPK1, GNAL, SNAP25, PRLR
6liver/biliary system phenotypeMP:00053709.7GCK, PBX1, SCG5, CEL, ATF2, FURIN
7hematopoietic system phenotypeMP:00053979.6PCSK1, BRCA1, LCN2, XIAP, P2RY6, ATF2
8normal phenotypeMP:00028739.0BTC, VIP, BRCA1, VAMP2, MYC, RAB3A
9no phenotypic analysisMP:00030128.9RB1, MYC, KCNJ11, LEPR, P2RY6, CDKN1B
10renal/urinary system phenotypeMP:00053678.9GCK, BRCA1, PBX1, KCNMA1, LEPR, CHGA
11limbs/digits/tail phenotypeMP:00053718.7RB1, BRCA1, PBX1, CHKB, ATF2, IGF2
12immune system phenotypeMP:00053878.6PCSK1, BRCA1, VAMP2, PBX1, KCNA5, SCG5
13behavior/neurological phenotypeMP:00053868.2PCSK2, PCSK1, RB1, SEMA6A, VIP, RAB3A
14embryogenesis phenotypeMP:00053808.1BRCA1, MYC, PBX1, SDHD, KCNH2, ATF2
15reproductive system phenotypeMP:00053897.7PCSK2, PCSK1, SEMA6A, VIP, BRCA1, PBX1
16digestive/alimentary phenotypeMP:00053817.6PCSK1, GCG, RB1, BRCA1, MYC, PBX1
17mortality/agingMP:00107687.4PCSK2, PCSK1, GCK, GCG, BTC, RB1
18hearing/vestibular/ear phenotypeMP:00053777.3RB1, MYC, PBX1, KCNMA1, ATF2, CDKN1A
19skeleton phenotypeMP:00053907.3PIK3CG, BTC, RB1, BRCA1, MYC, PBX1
20integument phenotypeMP:00107717.1PIK3CG, PCSK2, RB1, BRCA1, MYC, PBX1
21adipose tissue phenotypeMP:00053757.0PCSK1, RB1, BRCA1, MYC, KCNJ11, SCG5
22vision/eye phenotypeMP:00053916.9RB1, SEMA6A, LEPR, ATF2, CDKN1A, CDKN1B
23growth/size phenotypeMP:00053786.4PIK3CG, PCSK1, GCK, GCG, BTC, RB1
24nervous system phenotypeMP:00036316.3RB1, SEMA6A, BRCA1, MYC, RAB3A, PBX1
25muscle phenotypeMP:00053695.8PIK3CG, PCSK1, BTC, RB1, BRCA1, MYC
26homeostasis/metabolism phenotypeMP:00053765.3PIK3CG, REG3A, PCSK2, PCSK1, GCK, GCG
27cellular phenotypeMP:00053844.7PIK3CG, PCSK2, PCSK1, RB1, BRCA1, MYC
28tumorigenesisMP:00020064.7RB1, BRCA1, MYC, SDHD, LEPR, ATF2
29cardiovascular system phenotypeMP:00053854.4PIK3CG, PCSK2, PCSK1, BTC, RB1, BRCA1

Publications for genes affiliated with Insulinoma

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35PubMed
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Articles related to insulinoma:

(show top 50)    (show all 257)
idTitleAuthorsYearAffiliating Genes
1cMyc is a principal upstream driver of beta-cell prol iferation in rat insulinoma cell lines and is an effective mediator of human be ta-cell replication. (21885567)Karslioglu E.... Stewart A.F.2011MYC
2Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. (18783846)Mayer S.I.... Thiel G.2009EGR1, ELK1
3Hypoglycemia and insulinoma (19878764)Cazabat L.... Chanson P.2009GLP1R
4Role of aryl hydrocarbon receptor nuclear translocator in KATP channel-mediated insulin secretion in INS-1 insulinoma cells. (19141293)Kim J.S.... Chun Y.S.2009ARNT
5Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells. (19691144)Macdonald M.J.... Kendrick M.A.2009ME2
6Glucagon-like peptide-1 receptor imaging for localiza tion of insulinomas. (19820010)Christ E.... Reubi J.C.2009GLP1R
7Application of the intravenous glucose tolerance test and the minimal model to patients with insulinoma: insulin sensitivity (Si) and glucose effectiveness (Sg) before and after surgical excision. (18445139)Vethakkan S.R.... Ward G.M.2009INS
8Non-insulinoma persistent hyperinsulinaemic hypoglycaemia caused by an activating glucokinase mutation: hypoglycaemia unawareness and attacks. (18208578)Christesen H.B.... Brock Jacobsen B.2008GCK
9Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma. (18430790)Ono Y.... Itoh M.2008CASR
10Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. (18692019)Azzu V.... Brand M.D.2008UCP2
11Leptin induces inflammation-related genes in RINm5F insulinoma cells. (17521427)Hekerman P.... Becker W.2007SOD2, LCN2
12Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes. (17689130)Wang M.... Shen G.X.2007HSPA5, DDIT3
13Long-term in vitro growth of human insulin-secreting insulinoma cells. (16888402)Gartner W.... Wagner L.2006SCGN
14Usefullness of scintigraphy with somatostatin analogues in the imaging of insulinoma of the pancreas (16617742)Owecki M.... SowiA8ski J.2006SST
15Chromosomal instability predicts metastatic disease in patients with insulinomas. (15947114)Jonkers Y.M.... Speel E.J.2005MEN1
16Successful long-term treatment with once-daily injection of low-dose octreotide in an aged patient with insulinoma. (16284444)Katabami T.... Saito N.2005SST
17Chromosome 1q loss of heterozygosity frequently occurs in sporadic insulinomas and is associated with tumor malignancy. (15900598)Yang Y.M.... Chen J.2005MEN1
18IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation. (16154537)Kim H.S.... Lee M.S.2005XIAP
19The diagnosis and treatment of insulinoma and gastrinoma (15045936)Honda M.... Ishibashi M.2004SCT
20Genetically-driven or supposed genetic-related insulinomas in adults: validation of the surgical strategy proposed by the A.F.C.E./G.E.N.E.M. (15247875)Proye C.... .2004SCT
21Insulinomas and expression of an insulin splice variant. (15070567)Minn A.H.... Shalev A.2004INS
22Molecular pathways involved in the antineoplastic eff ects of calcitriol on insulinoma cells. (12697689)Galbiati F.... Davalli A.M.2003IGF1, CDKN1A, IGF2
23An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures. (12941771)Bennett R.G.... Duckworth W.C.2003IDE, IAPP
24An insulinoma for which secretin test and selective arterial calcium injection test were useful. (12413006)Tanaka N.... Fujii S.2002INS, SCT
25Study of the insulinotropic effect of the novel antih yperglycemic agent KAD-1229 using HIT T15 cells, a hamster's insulinoma cell li ne. (12236048)Ichikawa K.... Kojima M.2002ABCC8, INS
26Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells. (12475794)Bernal-Mizrachi E.... Permutt M.A.2002TNF
27Anesthetic management of two patients with insulinoma using propofol--in association with rapid radioimmunoassay for insulin (11244767)Kunisawa T.... Iwasaki H.2001INS
28Beta-cell gene expression and functional characterisation of the human insulinoma cell line CM. (10194529)1999GCK, SLC2A2
29Insulinoma with hyperproinsulinemia during hypoglycemia and loss of expression of vacuolar-type H(+)-ATPase (V-ATPase) in the tumor tissue. (10211416)Hiura A.... Satake K.1999SCT
30Functioning human insulinomas. An immunohistochemical analysis of intracellular insulin processing. (9870681)Azzoni C.... Bordi C.1998PCSK1, CPE, PCSK2
31Insulinoma. Clinical and surgical considerations concerning a case (9148220)Porzio O.... Porzio R.1997INS
32Overexpressed syntaxin 1A/HPC-1 inhibits insulin secretion via a regulated pathway, but does not influence glucose metabolism and intracellular Ca2+ in insulinoma cell line beta TC3 cells. (9070225)Nagamatsu S.... Akagawa K.1997SLC2A1, STX1A
33Expression of constructs between the glucose-6-phosphatase promoter and a reporter gene in an insulinoma cell line: regulation by glucose, dibutyryl cAMP and dexamethasone. (9191224)Schmoll D.... Burchell A.1997G6PC
34Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells. (7895663)Leech C.A.... Habener J.F.1995ADCYAP1
35The effect of botulinum neurotoxins on the release of insulin from the insulinoma cell lines HIT-15 and RINm5F. (7629139)Boyd R.S.... Foster K.A.1995INS
36Regulation of insulinoma cell proliferation and insulin accumulation by peptides and second messengers. (8808183)SjAPholm A.1995INS
37Expression of the ras-related rab3a gene in human insulinomas and normal human pancreatic islets. (7524063)Lankat-Buttgereit B.... Goke B.1994RAB3A
38Tumor and serum levels of proinsulin and insulin in insulinoma patients. (7951510)Tasaka Y.... Omori Y.1993INS
39A multiplicity of protein antigens in subcellular fractions of rat insulinoma tissue are able to stimulate T cells obtained from non-obese diabetic mice. (8314441)Bieg S.... Banga J.P.1993CPE
40Inhibitory effect of islet amyloid polypeptide of glucose-induced proinsulin biosynthesis in rat insulinoma cells. (1641390)Chuang L.M.... Lin B.J.1992INS
41A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs. (1634555)Goto Y.... Lan M.S.1992INSM1
42Involvement of pertussis toxin-sensitive G-proteins i n the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insu lin-secreting cell line (RINm5F). 18025-33 Adrenaline inhibits insulin secretion via pertuss is toxin-sensitive mechanisms. Since voltage-dependent Ca2+ currents play a key role in insulin secretion, we examined whether adrenaline modulates voltage-de pendent Ca2+ currents of the rat insulinoma cell line, RINm5F. In the whole-cel l configuration of the patch-clamp technique, dihydropyridine- but not omega-co notoxin-sensitive Ca2+ currents were identified. Adrenaline via alpha 2-adrenoc eptors inhibited the Ca2+ currents by about 50%. Somatostatin which also inhibi ts insulin secretion was less efficient (inhibition by 20%). The hormonal inhib ition of Ca2+ currents was not affected by intracellularly applied cAMP but blo cked by the intracellularly applied GDP analog guanosine 5'-O-(2-thiodiphosphat e) and by pretreatment of cells with pertussis toxin. In contrast to adrenaline and somatostatin, galanin, another inhibitor of insulin secretion, reduced Ca2 + currents by about 40% in a pertussis toxin-insensitive manner. Immunoblot exp eriments performed with antibodies generated against synthetic peptides reveale d that membranes of RINm5F cells possess four pertussis toxin-sensitive G-prote ins including Gi1, Gi2, Go2, and another Go subtype, most likely representing G o1. In membranes of control but not of pertussis toxin-treated cells, adrenalin e via alpha 2-adrenoceptors stimulated incorporation of the photo-reactive GTP analog [alpha-32P]GTP azidoanilide into pertussis toxin substrates comigrating with the alpha-subunits of Gi2, Go2, and the not further identified Go subtype. The present findings indicate that activated alpha 2-adrenoceptors of RINm5F c ells interact with multiple G-proteins, i.e. two forms of Go and with Gi2. Thes e G-proteins are likely to be involved in the adrenaline-induced inhibition of dihydropyridine-sensitive Ca2+ currents and in other signal transduction pathwa ys contributing to the adrenaline-induced inhibition of insulin secretion. Institut fA1r Pharmakologie, Freie UniversitAot Berlin, Federal Republic of Germany. Schmidt A A Hescheler J J Offermanns S S Spicher K K Hinsch K D KD Klinz F J FJ Codina J J Birnbaumer L L Gausepohl H H Frank R R eng Journal Article Research Support, Non-U.S. Gov't UNITED STATES J Biol Chem 2985121R 0021-9258 0 Dihydropyridines 0 Hormones 0 Virulence Factors, Bordetella 11061-68-0 Insulin 3337-17-5 1,4-dihydropyridine 4205-90-7 Clonidine 51-43-4 Epinephrine 51110-01-1 Somatostatin 7440-70-2 Calcium EC 2.4.2.31 Pertussis Toxin EC 3.6.1.- GTP-Binding Proteins IM Animals Calcium metabolism Clonidine pharmacology Dihydropyridines pharmacology Electrophoresis, Polyacrylamid e Gel Epinephrine physiology GTP-Binding Proteins metabolism Hormones physiology Insulin secretion Insulinoma pathology secretion Membrane Potentials Pertussis Toxin Rats Somatostatin physiology Tumor Cells, Cultured secretion Virulence Factors, Bordetella pharmacology 1991 9 25 1991 9 25 0 1 1991 9 25 0 0 ppublish 1680855 1680855 1991 10 29 1991 10 29 2006 11 15
0021-9258 266 27 1991 Sep 25 The Journal of biological chemistry J. Biol. Chem. Involvement of pertussis toxin-sensitive G-proteins i n the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insu lin-secreting cell line (RINm5F). (4)
Schmidt A.... Frank R.1991KLK5
43Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. (1986382)Philipson L.H.... Steiner D.F.1991KCNA3, KCNA5, KCNA4
44Expression of functional human Epstein-Barr virus/C3d receptor ([CR2] CD21) on insulinoma cell line. Induction of tumor rejection but not diabetes in syngeneic rats. (1647992)Carel J.C.... Lacy P.E.1991CR2
45Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats. (1954888)Hakes D.J.... Dixon J.E.1991FURIN
46Expression of liver type pyruvate kinase in insulinoma cells: involvement of LF-B1 (HNF1). (1720308)Noguchi T.... Tanaka T.1991PKLR, HNF1A
47Unresponsiveness of insulinoma cells to secretin: significance of the secretin test in patients with insulinoma. (2166285)Imamura M.... Tobe T.1990INS, SCT
48Somatostatin analogues in the management of benign insulinomas. (2155883)Laron Z.1990SST
49Stimulatory effects of maitotoxin on insulin release in insulinoma HIT cells: role of calcium uptake and phosphoinositide breakdown. (2175805)Soergel D.G.... Daly J.W.1990INS
50Evolutionary conservation of the insulinoma gene rig and its possible function. (2821540)Inoue C.... Okamoto H.1987RPS15

Expression for genes affiliated with Insulinoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Insulinoma

Pathways for genes affiliated with Insulinoma

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20KEGG, 34PharmGKB, 3Cell Signaling Technology, 10EMD Millipore, 37R&D Systems, 41Thomson Reuters, 36QIAGEN
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Pathways related to insulinoma according to GeneDecks:

(show top 50)    (show all 219)
idPathwayScoreTop Affiliating Genes
1Maturity onset diabetes of the young2011.3NEUROG3, NEUROD1, SLC2A2, PDX1, PKLR, HNF4A
2Type II diabetes mellitus2011.1ABCC8, SLC2A2, PDX1, PKLR, GCK, KCNJ11
3Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics3411.1KCNJ11, INS, INSR, MAFA, CACNA1D, AKT1
4Glucose / Energy Metabolism310.8PDX1, PRKAA1, OGT, NEUROD1, WFS1, GAD2
5EGFR Inhibitor Pathway, Pharmacodynamics3410.8CAMK2D, STAT5A
6Development EGFR signaling pathway1010.8BTC
7Potassium transporters- outward current1010.7KCNA3, KCNA5, KCNJ11, KCNJ6, ABCC8, KCNMA1
8Adipocytokines & Insulin Signaling3710.4ELK1, FOS, PIK3CG, INSR, PRKAA1, PRKCB
9Development_Growth hormone signaling via PI3K/AKT and MAPK cascades4110.1ELK1, EGR1, DDIT3, ATF2, GHR, GH1
10CREB Pathway3610.0ELK1, PLCD1, PLCB1, GHRH, GH1, CAMK2D
11Type I diabetes mellitus2010.0INS, IL1A, IL1B, ICA1, TNF, PTPRN2
12Akt Signaling369.6TNF, ERBB4, GNAL, IL15, IL11, BTC
13Development Growth hormone signaling via PI3K/AKT and MAPK cascades109.2FOS, ELK1, DDIT3, GHR, GH1, AKT1
14Breast Cancer Regulation by Stathmin1369.1PLCB1, PLCD1, ERBB4, GHRH, CAMK2D, GNAL
15Development ERBB-family signaling108.9MYC, BTC, ERBB4, EGF, TGFA, ELK1
1614-3-3 Induced Intracellular Signaling368.8ERBB4, BTC, INSR, IL9, MAPK1, IGF1
17Activation of cAMP-Dependent PKA368.8GCG, BTC, IL9, MAPK1, CXCL12, IGF2
18Non-small cell lung cancer208.7PRKCA, PRKCB, TGFA, EGF, AKT1, CDK4
19Development_ERBB-family signaling418.5ERBB4, BTC, FOS, MAPK1, EGF, ELK1
20Chronic myeloid leukemia208.3PIK3CG, STAT5A, TGFB1, SMAD4, MYC, AKT1
21Tec Kinases Signaling368.3IL9, IGF1, IL11, INSR, FOS, BTC
22Glioblastoma Multiforme368.3IGF2, RB1, CDKN1A, CDKN1B, CDK4, MAPK1
23Ras Pathway368.1CXCL12, TGFA, ELK1, EGFR, EGF, ERBB4
24Signaling Involved in Cardiac Hypertrophy368.1ELK1, TGFB1, PRKCA, AKT1, EGFR, PLCB1
25IP3 Pathway368.0BTC, CXCL12, GNAL, IL9, IGF2, IGF1
26Endothelin-1 Signaling Pathway368.0IL11, IL1A, IL1B, IL9, GNAL, CASP1
27DHA Signaling368.0CASP1, TGFA, EGF, PLA2G6, CXCL12, CYCS
28Rap1 Pathway367.8GH1, GHRH, ERBB4, EGF, EGFR, TGFA
29Intracellular Calcium Signaling367.8GHRH, TGFA, CACNA1E, PLCD1, GH1, CACNA1D
30Development_EGFR signaling pathway417.7FOS, TGFA, PRKCB, ELK1, AKT1, EGFR
31ErbB signaling pathway207.7MAPK1, CAMK2D, AKT1, ERBB4, EGF, EGFR
32Activation of PKC through GPCR367.7BTC, EGFR, IL9, MAPK1, IGF2, EGF
33GPCR Pathway367.5PLCB1, CXCL12, EGF, EGFR, ELK1, TGFA
34Glioma207.5PIK3CG, RB1, AKT1, PRKCA, PRKCB, EGFR
35NFAT in Immune Response367.4GNAL, IGF1, IGF2, MAPK1, IL9, INSR
36cAMP Pathway367.3IGF2, GHRH, PLA2G6, PLCD1, EGF, EGFR
37Pancreatic Adenocarcinoma367.3MAPK1, ELK1, TGFA, IGF1, EGFR, EGF
38NF-KappaB Family Pathway367.3IGF1, CXCL12, PRKCA, TNF, TGFB1, TGFA
39Estrogen Pathway367.3GHRH, ERBB4, EGF, EGFR, ELK1, TGFA
40NF-KappaB (p50-p65) Pathway367.3AKT1, CXCL12, BTC, IL1A, IL1B, IL1R1
41p38 Signaling367.0INSR, IGF1, IGF2, IL9, IL1R1, IL1B
42ERK Signaling367.0ELK1, CACNA1E, GNAL, IGF2, MAPK1, IL9
43TGF-Beta Pathway367.0CXCL12, EGFR, EGF, TGFA, GHRH, IL11
44MAPK Family Pathway366.7EGF, GHRH, GH1, IGF1, MAPK1, TNF
45JAK-STAT Pathway366.5MYC, INSR, IL11, IL15, IL1A, IL1B
46Pathways in cancer206.5AKT1, RB1, TGFA, PIK3CG, TGFB1, PRKCB
47Antioxidant Action of Vitamin-C366.4EGF, PLCB1, EGFR, ELK1, PLCD1, TNF
48MAPK signaling pathway206.2EGFR, CACNA1E, NF1, TNF, DDIT3, PLA2G6
49MAPK Signaling366.0BTC, PLCB1, EGF, EGFR, ELK1, TGFA
50Molecular Mechanisms of Cancer365.7IL9, IL1R1, IL15, IL11, INSR, FOS

Compounds for genes affiliated with Insulinoma

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to insulinoma according to GeneDecks:

(show top 50)    (show all 484)
idCompoundScoreTop Affiliating Genes
1glucose32 11.4REG3A, PC, PCSK2, PCSK1, GCG, BTC
2histidine32 11.1KCNH2, KCNJ11, SCG5, SCT, CHGA, FURIN
3potassium32 9 18 9 13.9GCK, VIP, KCNA3, KCNA5, KCNH2, KCNJ11
4sulfonylurea32 10.8GCK, GCG, KCNJ11, KCNJ5, IAPP, GLP1R
5carbachol32 9 9 12.8GCG, SCT, GRP, IL11, CACNA1B, SST
6glibenclamide32 34 11.8GCG, VIP, KCNJ11, KCNJ5, KCNMA1, INS
7pyruvate32 10.7PC, PCSK2, GCK, SDHB, CHKB, UCP1
8propranolol32 34 9 18 9 14.6VIP, KCNH2, SCT, CHGA, CGB5, CDKN3
9oxyntomodulin32 42 11.6PCSK2, PCSK1, GCG, VIP, SCT, CHGA
10lanreotide32 10.5CHGA, IGF1, GH1, GHR, GHRH, GHSR
11dmso32 10.4SDHB, CHGA, CGB5, INSR, CASP1, GH1
12triiodothyronine32 10.4PCSK2, LEPR, CHKB, UCP1, UCP2, UCP3
13haloperidol32 34 9 9 13.2VIP, KCNH2, KCNJ5, CHGA, FOS, IL1R1
14egcg32 10.1PIK3CG, XIAP, IL1A, CAT, DDIT3, CYCS
15nifedipine32 9 9 12.1PIK3CG, GCG, VIP, KCNJ5, KCNMA1, CHGA
165-hydroxytryptamine32 10.0GCG, VIP, SCG2, CHGA, CDKN3, GRP
17octreotide32 42 9 9 13.0GCG, VIP, SCT, CHGA, INS, INSR
18threonine32 10.0KCNH2, SCG5, CDKN1B, IL1RAPL2, GLUD1, HNF4A
19thyroxine32 18 10.8VIP, SCT, LEPR, CHKB, UCP1, UCP2
20cyclic amp32 18 10.8PCSK2, GCG, RB1, PBX1, KCNH2, KCNMA1
21gtp32 9.7GCK, VIP, RAB3A, KCNJ3, KCNMA1, CHKB
22clonidine32 9 9 11.6SCT, CHGA, IL1RAPL2, IGF1, CACNA1B, CALCA
23gnrh32 9.6PCSK1, GCG, PBX1, SCG2, LEPR, CGB5
24corticosterone32 18 10.5GCG, VIP, LEPR, CGB5, FOS, GRP
25cysteine32 9.1GCK, GCG, SERPINA1, BRCA1, SDHB, SCG2
26dihydrotestosterone32 9 18 9 12.0VIP, CHKB, CGB5, CDKN1B, CDK4, INSR
27thapsigargin32 42 9.9PIK3CG, VIP, KCNMA1, CDKN3, GRP, MAPK1
28chelerythrine32 8.9PIK3CG, KCNJ5, CDKN3, FOS, MAPK1, IGF1
29vitamin d32 8.9SCG5, LEPR, CHGA, CHKB, CDKN1A, CDK4
30prostaglandin32 8.8VIP, KCNJ5, SCT, UCP2, CGB5, CDK4
31hydrocortisone32 9 9 10.7PBX1, INS, INSR, GRP, IL15, IL1A
32nitric oxide32 9 18 9 11.7GCK, RB1, SERPINA1, KCNJ5, KCNMA1, CHGA
33calcium32 9 18 9 11.6PCSK2, PCSK1, GCK, BTC, RB1, VIP
34glutamine32 8.6PIK3CG, PC, GCK, GCG, VIP, BRCA1
35rosiglitazone32 9 18 9 11.5PIK3CG, UCP1, UCP2, UCP3, LCN2, CDKN1A
36atp32 8.5PC, GCK, RB1, BRCA1, SDHB, KCNJ11
37pge232 8.5VIP, KCNMA1, SCT, CGB5, ATF2, GSR
38calcitriol32 42 9 18 9 12.4RB1, MYC, XIAP, ATF2, CDKN1A, CDKN1B
39arsenite32 18 9.0PIK3CG, MYC, KCNH2, XIAP, CDKN1A, CDKN3
40progesterone32 42 9 18 9 12.0PCSK1, GCK, BTC, RB1, BRCA1, PBX1
41gf 109203x32 42 8.9PIK3CG, CDKN1A, CDKN3, FOS, GRP, MAPK1
42phosphoinositide32 7.9PIK3CG, LEPR, CDKN1B, CDKN3, FOS, INSR
43testosterone32 9 18 9 10.9RB1, VIP, BRCA1, PBX1, SDHB, KCNH2
44ribonucleic acid32 7.7PCSK2, PCSK1, MYC, LEPR, CHGA, UCP1
45indomethacin32 9 9 9.5GCG, VIP, MYC, KCNJ5, SCT, CGB5
46tamoxifen32 34 9 9 10.0BRCA1, MYC, KCNMA1, CHGA, CHKB, CGB5
47paclitaxel32 34 9 9 8.7PIK3CG, RB1, BRCA1, MYC, CHGA, XIAP
48thymidine32 18 6.4REG3A, BTC, RB1, SERPINA1, VIP, BRCA1
49pd 98,05932 5.2PIK3CG, GCG, BTC, RB1, MYC, SCT
50genistein32 9 18 9 8.1PIK3CG, GCG, RB1, BRCA1, MYC, CGB5

GO Terms for genes affiliated with Insulinoma

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Sources:
12Gene Ontology
See all sources

Cellular components related to insulinoma according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.9GAL, GCK, PCSK1, PCSK2, GCG, SCG2
2transport vesicle membraneGO:03065810.8CPE, SLC30A8, SNTB2, PTPRN2, ICA1, CHGA
3voltage-gated potassium channel complexGO:00807610.8KCNJ3, KCNJ5, KCNMA1, SNAP25, ABCC8, KCNA4
4clathrin sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.7GAD2, GAD1, SYT1, RAB3A, VAMP2
5clathrin sculpted monoamine transport vesicle membraneGO:07008310.6SLC18A2, SYT1, RAB3A, VAMP2
6neuronal cell bodyGO:04302510.6ADCY10, SLC18A2, PRKCA, TGFB1, SNAP25, SST
7synaptic vesicle membraneGO:03067210.5GAD2, SLC18A2, STX1A, SYT1, ICA1, VAMP2
8clathrin sculpted glutamate transport vesicle membraneGO:06020310.4VAMP2, RAB3A, SYT1
9integral to plasma membraneGO:00588710.1SSTR2, SSTR1, PTPRN, PTPRN2, PTPRU, SSTR3
10caveolaGO:0059019.8SLC2A1, CTSB, ERBB4, MAPK1, INSR, KCNMA1
11basolateral plasma membraneGO:0163239.2EPCAM, SLC2A2, SLC2A1, CXADR, TGFA, EGFR
12axonGO:0304249.2GAD2, ADCY10, TGFB1, NF1, DDC, GHRL
13cell surfaceGO:0099868.9EPCAM, PRLR, TGFB1, TGFA, PTPRT, TNF
14extracellular regionGO:0055768.4ADM, EMC10, CPE, NPY, CST3, CXCL12
15cytosolGO:0058298.4RPS15, NNMT, PLCB1, PLCD1, PLA2G6, SMAD4
16nucleoplasmGO:0056548.2DDIT3, ERBB4, ESR2, HNF4A, AKT1, SMAD4
17plasma membraneGO:0058867.6PTPRT, CACNA1D, CACNA1E, CACNA1B, GNAL, GOPC
18extracellular spaceGO:0056157.4INS, FURIN, SCG2, SERPINA1, BTC, GCG

Biological processes related to insulinoma according to GeneDecks:

(show top 50)    (show all 78)
idNameGO IDScoreTop Affiliating Genes
1endocrine pancreas developmentGO:03101811.2PAX4, INS, INSM1, IAPP, AKT1, HNF4A
2glucose homeostasisGO:04259311.1FFAR1, AKT1, HNF1A, HNF4A, SSTR5, CRTC2
3somatostatin signaling pathwayGO:03817011.1SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
4positive regulation of insulin secretionGO:03202411.1SLC30A8, SNAP25, GHRL, GIPR, GIP, GLUD1
5insulin secretionGO:03007311.0GAL, NEUROD1, SLC18A2, SLC30A8, PDX1, HNF1A
6growth hormone secretionGO:03025211.0GAL, SNAP25, GHSR, GHRL, GHRH
7positive regulation of multicellular organism growthGO:04001811.0STAT5A, GHSR, GHRL, GHRH, GHR, GH1
8response to nutrientGO:00758410.9OGT, PKLR, SSTR2, SSTR1, SST, DDIT3
9neurotransmitter secretionGO:00726910.8GAD2, GAD1, SLC18A2, STX1A, SYT1, SNAP25
10G-protein coupled receptor signaling pathwayGO:00718610.8GHSR, SST, SSTR4, SSTR5, CXCL12, GAST
11response to glucose stimulusGO:00974910.8PCSK1, NEUROD1, SLC2A2, INSR, MAFA, GLP1R
12elevation of cytosolic calcium ion concentrationGO:00720410.7ADM, GHRL, GHRH, GIPR, GLP1R, CALCA
13activation of adenylate cyclase activityGO:00719010.7ADCYAP1, PRKCA, GIPR, GLP1R, CALCA, GNAL
14energy reserve metabolic processGO:00611210.7INS, FFAR1, CACNA1E, CACNA1D, GLP1R, GIP
15potassium ion transportGO:00681310.7KCNJ5, KCNMA1, CDKN1B, ABCC8, KCNJ3, KCNA4
16response to foodGO:03209410.6GHSR, GHRH, GHR, AKT1
17positive regulation of glycolysisGO:04582110.6PRKAA1, IGF1, INSR, INS, ARNT, GCK
18glutamate secretionGO:01404710.6STX1A, SYT1, SNAP25, RAB3A, VAMP2
19glucose transportGO:01575810.6SLC2A2, SLC2A1, G6PC, GH1, AKT1, INS
20cell-cell signalingGO:00726710.6SST, SSTR1, SSTR2, SSTR3, ADM, ADCYAP1
21small molecule metabolic processGO:04428110.6CRAT, SMPD2, SNAP25, CYCS, DDC, GIP
22G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.5NPY, SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
23positive regulation of glycogen biosynthetic processGO:04572510.5AKT1, IGF1, IGF2, INSR, INS, GCK
24regulation of insulin secretionGO:05079610.4SNAP25, ABCC8, STX1A, PRKCA, SLC2A1, SLC2A2
25positive regulation of anti-apoptosisGO:04576810.2ADM, PRKAA1, ERBB4, AKT1, CDKN1A, PAX4
26agingGO:00756810.1ADM, SLC18A2, PRKCA, TGFB1, TSPO, DDIT3
27response to organic cyclic compoundGO:01407010.1PRKCA, PKLR, CTSB, GIP, CASP1, IL1A
28positive regulation of cell divisionGO:0517819.9TGFB1, TGFA, CAT, IGF2, IL1B, IL1A
29glucose metabolic processGO:0060069.8PRKAA1, PDX1, PKLR, TNF, GHRL, AKT1
30synaptic transmissionGO:0072689.6VAMP2, CAMK2D, SST, SNAP25, PLCB1, ABCC8
31positive regulation of protein phosphorylationGO:0019349.4PRKCA, TGFB1, TNF, ERBB4, AKT1, IGF2
32positive regulation of apoptotic processGO:0430659.3PDIA3, TSPO, NEUROD1, ADCY10, GAL, NF1
33activation of MAPK activityGO:0001879.3PRKAA1, TGFA, TNF, GHRL, GHR, MAPK1
34cell cycle arrestGO:0070509.1TGFB1, DDIT3, MEN1, CDKN3, CDKN1B, CDKN1A
35response to drugGO:0424939.1TGFA, TSPO, NNMT, SST, TGFB1, NME1
36negative regulation of cell proliferationGO:0082859.0SSTR2, SSTR3, SSTR4, SSTR5, SMAD4, PDX1
37positive regulation of mitosisGO:0458409.0TGFA, EGF, TNF, IGF1, IGF2, IL1B
38positive regulation of nitric oxide biosynthetic processGO:0454299.0EGFR, TNF, AKT1, IL1B, INSR, INS
39response to hypoxiaGO:0016668.9SMAD4, PKLR, NF1, TGFB1, PRKAA1, CXCL12
40anti-apoptosisGO:0069168.8PRLR, TGFA, TNF, GHRL, AKT1, HSPA5
41positive regulation of protein kinase B signaling cascadeGO:0518978.7TGFB1, EGFR, TNF, IGF1, IGF2, GPX1
42positive regulation of epithelial cell proliferationGO:0506798.5NME1, TGFB1, TGFA, EGFR, ERBB4, IGF1
43positive regulation of cell proliferationGO:0082848.4PDX1, ERBB4, GHRH, GLP1R, EGF, EGFR
44positive regulation of MAP kinase activityGO:0434068.3TGFB1, EGFR, EGF, TNF, GH1, PIK3CG
45positive regulation of transcription from RNA polymerase II promoterGO:0459448.1PDX1, SMAD4, DDIT3, TNF, HNF4A, EGR1
46negative regulation of apoptotic processGO:0430668.0TNF, ERBB4, GHRL, AKT1, EGFR, PRKAA1
47platelet activationGO:0301687.9PRKCA, PRKCB, TGFB1, EGF, AKT1, HSPA5
48MAPK cascadeGO:0001657.6TGFB1, TGFA, EGFR, NF1, TNF, MAPK1
49positive regulation of transcription, DNA-dependentGO:0458937.5ERBB4, TNF, SMAD4, PLCB1, EGF, EGR1
50signal transductionGO:0071657.1NTS, PLCB1, PDIA3, EGF, EGFR, PRKAA1

Molecular functions related to insulinoma according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:00499411.0SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
2hormone activityGO:00517910.7GIP, GH1, SST, ADM, GAST, CALCA
3peptide hormone bindingGO:01704610.7PRLR, GHSR, GHR, GIPR, GLP1R
4neuropeptide hormone activityGO:00518410.7GAL, ADCYAP1, NPY, NTS, GRP, VIP
5G-protein activated inward rectifier potassium channel activityGO:01546710.5KCNJ6, KCNJ3, KCNJ5
6receptor bindingGO:00510210.3CRAT, CXADR, CXCL12, NPY, ADM, ADCYAP1
7sequence-specific DNA bindingGO:0435659.9HMX1, DDIT3, SMAD4, PDX1, EGR1, ELK1
8insulin-like growth factor receptor bindingGO:0051599.9IGF1, IGF2, INSR, INS
9protease bindingGO:0020209.7CST3, TNF, IL1R1, INS, FURIN, SERPINA1
10double-stranded DNA bindingGO:0036909.4NEUROG3, NEUROD1, STAT5A, EGR1, EGFR, MEN1
11sequence-specific DNA binding transcription factor activityGO:0037009.4HMX1, DDIT3, SMAD4, PDX1, EGR1, ELK1
12growth factor activityGO:0080838.9CXCL12, TGFB1, TGFA, EGF, GH1, IGF1
13enzyme bindingGO:0198998.3PRKCA, TGFB1, THRB, EGFR, PLCB1, ESR2
14protein bindingGO:0055153.3ETV7, CYCS, SSTR2, SSTR3, CTSB, SNTB2

Sources for Insulinoma

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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