MCID: INT063
MIFTS: 51

Intellectual Disability malady

Neuronal diseases category

Summaries for Intellectual Disability

About this section
Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.

MalaCards: Intellectual Disability, also known as mental retardation, autosomal recessive 15, is related to mental retardation and alpha-thalassemia x-linked intellectual disability syndrome. An important gene associated with Intellectual Disability is MAN1B1 (mannosidase, alpha, class 1B, member 1). Affiliated tissues include testes, brain and breast.

Wikipedia:63 Intellectual disability (ID) or general learning disability is a generalized disorder appearing before... more...

Description from OMIM:46 309583, 614202, 300436, 300387, 300849 300486, 300210, 300844, 300143, 300558, 613192 more

Aliases & Classifications for Intellectual Disability

About this section
Sources:
8Disease Ontology, 20GeneTests, 10DISEASES, 9diseasecard, 22GTR, 46OMIM, 27ICD9CM, 56SNOMED-CT, 60UMLS, 34MeSH, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

intellectual disability 8 20 10
mental retardation, autosomal recessive 15 8 9 22 46


Related Diseases for Intellectual Disability

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Intellectual Disability family:

Kansl1-Related Intellectual Disability Syndrome Cask-Related Intellectual Disability

Diseases related to Intellectual Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 370)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation30.4FRAXE, ATRX
2alpha-thalassemia x-linked intellectual disability syndrome10.6
3developmental disabilities10.5
4down syndrome10.5
5autism spectrum disorder10.5
6microcephaly10.4
7fragile x syndrome10.4
8obesity10.4
9blepharophimosis intellectual disability syndromes10.4
10male pseudohermaphroditism intellectual disability syndrome, verloes type10.3
11dementia10.3
12williams syndrome10.3
13cask-related intellectual disability10.3
14neuronitis10.3
15learning disability10.3
16trichomegaly with intellectual disability, dwarfism and pigmentary degeneration of retina10.3
17x-linked intellectual disability-retinitis pigmentosa syndrome10.3
18bipolar disorder10.2
19attention deficit hyperactivity disorder10.2
20angelman syndrome10.2
21autistic disorder10.2
22phenylketonuria10.2
23cervicitis10.2
24epilepsy syndrome10.2
25schizophrenia10.2
26kansl1-related intellectual disability syndrome10.2
27snyder-robinson syndrome10.2
28fragile xe syndrome10.2
29rett syndrome10.1
30williams-beuren syndrome10.1
31kbg syndrome10.1
32congenital hypothyroidism10.1
33cerebritis10.1
34wolf-hirschhorn syndrome10.1
35lennox-gastaut syndrome10.1
36west syndrome10.1
37succinic semialdehyde dehydrogenase deficiency10.1
38cleft palate10.1
39breast cancer10.1
40cerebral palsy10.1
41cervical cancer10.1
42congenital heart defect10.1
43muscular dystrophy10.1
44paraplegia10.1
45sleep disorder10.1
46kabuki syndrome10.1
47pitt-hopkins syndrome10.1
48pallister-killian mosaic syndrome10.1
49ring chromosome 1410.1
50ppm-x syndrome10.1

Graphical network of the top 20 diseases related to Intellectual Disability:



Diseases related to intellectual disability

Clinical Features for Intellectual Disability

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

309583, 614202, 300436, 300387, 300849, 300486, 300210, 300844, 300143, 300558 613192 more

Clinical synopsis from OMIM:

614202

Drugs & Therapeutics for Intellectual Disability

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Intellectual Disability

Drug clinical trials:

Search ClinicalTrials for Intellectual Disability

Search NIH Clinical Center for Intellectual Disability

Search CenterWatch for Intellectual Disability

Genetic Tests for Intellectual Disability

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Intellectual Disability:

id Genetic test Affiliating Genes
1 Intellectual Disability Multi-Gene Panels20
2 Mental Retardation, Autosomal Recessive 1522

Anatomical Context for Intellectual Disability

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Intellectual Disability:

32
Testes, Brain, Breast, Bone, Heart, Skin, Eye, Thyroid, Kidney, Pituitary

Animal Models for Intellectual Disability or affiliated genes

About this section

Publications for Intellectual Disability

About this section
Sources:
50PubMed
See all sources

Articles related to Intellectual Disability:

(show top 50)    (show all 797)
idTitleAuthorsYear
1
Parent-child problem solving in families of children with or without intellectual disability. (23336566)
2014
2
Intellectual disability in young people in custody in New South Wales, Australia - prevalence and markers. (24422559)
2014
3
Residential treatment of serious behavioral disturbance in autism spectrum disorder and intellectual disability. (24231171)
2014
4
Diagnostic Exome Sequencing Identifies Two Novel IQSEC2 Mutations Associated with X-Linked Intellectual Disability with Seizures: Implications for Genetic Counseling and Clinical Diagnosis. (24306141)
2013
5
Classification of intellectual disability using the Wechsler Intelligence Scale for Children: Full Scale IQ or General Abilities Index? (23859669)
2013
6
Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation. (23335808)
2013
7
Maternal conditions and perinatal characteristics associated with autism spectrum disorder and intellectual disability. (23308096)
2013
8
Homozygous deletion in TUSC3 causing syndromic intellectual disability: a new patient. (23825019)
2013
9
Ageing with an intellectual disability: the impact of personal resources on well-being. (22974110)
2013
10
XY sex reversal, pontocerebellar hypoplasia and intellectual disability: confirmation of a new syndrome. (23686794)
2013
11
Autism and intellectual disability. (23423245)
2013
12
Systematic molecular and cytogenetic screening of 100 patients with marfanoid syndromes and intellectual disability. (23506379)
2013
13
Intellectual disability, unusual facial morphology and hand anomalies in sibs. (23949889)
2013
14
Friendship quality in adolescents with and without an intellectual disability. (23620246)
2013
15
Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders: a perspective. (24198768)
2013
16
Intellectual disability and space: critical narratives of exclusion. (23360410)
2013
17
De novo 3q22.1 q24 deletion associated with multiple congenital anomalies, growth retardation and intellectual disability. (23313878)
2013
18
AP1S2 is mutated in X-linked Dandy-Walker malformation with intellectual disability, basal ganglia disease and seizures (Pettigrew syndrome). (23756445)
2013
19
Intellectual disability and co-occurring mental health and physical disorders in aggressive behaviour. (23952483)
2013
20
Parent education for adults with intellectual disability: A review and suggestions for future research. (24088181)
2013
21
The auditory and speech performance of children with intellectual disability after cochlear implantation. (23066719)
2013
22
Using administrative health data to identify individuals with intellectual and developmental disabilities: a comparison of algorithms. (23116328)
2013
23
A controlled clinical evaluation of the Parents Plus Children's Programme for parents of children aged 6-12 with mild intellectual disability in a school setting. (23104965)
2013
24
Feasibility of eight physical fitness tests in 1,050 older adults with intellectual disability: results of the healthy ageing with intellectual disabilities study. (23360407)
2013
25
Train the trainer? A randomized controlled trial of a multi-tiered oral health education programme in community-based residential services for adults with intellectual disability. (23039926)
2013
26
Adapted Physical Activity Programme and Self-Perception in Obese Adolescents with Intellectual Disability: Between Morphological Awareness and Positive Illusory Bias. (23657846)
2013
27
Palmo-Plantar hyperkeratosis, intellectual disability, and spastic paraplegia in two maternal half brothers: further evidence for an X-linked inheritance. (23613454)
2013
28
A parallel study of different array-CGH platforms in a set of Spanish patients with developmental delay and intellectual disability. (23524024)
2013
29
Predictors of health-related and global quality of life among young adults with difficult-to-treat epilepsy and mild intellectual disability. (23324453)
2013
30
Tackling stigma associated with intellectual disability among the general public: a study of two indirect contact interventions. (23644953)
2013
31
Death by mental retardation? The influence of ambiguity on death certificate coding error for adults with intellectual disability. (22957894)
2013
32
Preventable visual impairment in children a8"with nonprofound intellectual disability. (23640505)
2013
33
Computerized training of non-verbal reasoning and working memory in children with intellectual disability. (23060775)
2012
34
Intellectual disability associated with retinal dystrophy in the Xp11.3 deletion syndrome: ZNF674 on trial. Guilty or innocent? (22126752)
2012
35
Trauma in people with intellectual and developmental disabilities: reactions of parents and caregivers to research participation. (22731969)
2012
36
Experiencing rights within positive, person-centred support networks of people with intellectual disability in Australia. (23106750)
2012
37
Effectiveness of a caregiver education program on providing oral care to individuals with intellectual and developmental disabilities. (22731971)
2012
38
Post-electroconvulsive therapy status epilepticus and tardive seizure in a patient with rapid cycling bipolar disorder, epilepsy, and intellectual disability. (22868490)
2012
39
Superior mesenteric artery syndrome in intellectually disabled children. (22453730)
2012
40
A de novo 1.13A Mb microdeletion in 12q13.13 associated with congenital distal arthrogryposis, intellectual disability and mild dysmorphism. (22534424)
2012
41
Family members' reports of the technology use of family members with intellectual and developmental disabilities. (21988242)
2012
42
A novel deletion mutation in the TUSC3 gene in a consanguineous Pakistani family with autosomal recessive nonsyndromic intellectual disability. (21513506)
2011
43
De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment. (20950788)
2010
44
Expenditure patterns for ICF/MR and HCBS long-term supports for persons with intellectual or developmental disabilities: fiscal years 2004-2009, with projections to fiscal year 2012. (21166554)
2010
45
Blood parameters in adults with intellectual disability at rest and after endurance exercise. (19479628)
2009
46
Penile hygiene: puberty, paraphimosis and personal care for men and boys with an intellectual disability. (19054270)
2009
47
Behavioural effects of phenylalanine-free amino acid tablet supplementation in intellectually disabled adults with untreated phenylketonuria. (16278987)
2005
48
Helicobacter pylori: has the killer escaped from the institution? A possible cause of increased stomach cancer in a population with intellectual disability. (11422646)
2001
49
'A woman's heaven is at her husband's feet'? The dilemmas for a community learning disability team posed by the arranged marriage of a Bangladeshi client with intellectual disability. (10622372)
1999
50
Multiple personality disorder in an intellectually disabled man: a case report. (7625965)
1995

Genetic Variations for Intellectual Disability

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Intellectual Disability:

62
id Symbol AA change Variation ID SNP ID
1MAN1B1p.Arg334CysVAR_066592
2MAN1B1p.Glu397LysVAR_066593

Expression for genes affiliated with Intellectual Disability

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intellectual Disability

Search GEO for disease gene expression data for Intellectual Disability.

Pathways for genes affiliated with Intellectual Disability

About this section

Compounds for genes affiliated with Intellectual Disability

About this section

GO Terms for genes affiliated with Intellectual Disability

About this section

Products for genes affiliated with Intellectual Disability

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intellectual Disability

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet