MCID: INT063
MIFTS: 42

Intellectual Disability malady

Summaries for Intellectual Disability

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.

MalaCards: Intellectual Disability, also known as mental retardation, autosomal recessive 15, is related to mental retardation and alpha-thalassemia x-linked intellectual disability syndrome. An important gene associated with Intellectual Disability is MAN1B1 (mannosidase, alpha, class 1B, member 1).

Wikipedia:64 Intellectual disability (ID) or general learning disability is a generalized disorder appearing before... more...

Description from OMIM:47 309583, 614202, 300436, 300387, 300849 300486, 300210, 300844, 300143, 300558, 613192 more

Aliases & Classifications for Intellectual Disability

Sources:
8Disease Ontology, 20GeneTests, 10DISEASES, 9diseasecard, 22GTR, 47OMIM, 27ICD9CM, 57SNOMED-CT, 61UMLS, 35MeSH, 40NCIt
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Aliases & Descriptions:

intellectual disability 8 20 10
mental retardation, autosomal recessive 15 8 9 22 47


Related Diseases for Intellectual Disability

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intellectual Disability via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 357)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation30.6FRAXE, ATRX
2alpha-thalassemia x-linked intellectual disability syndrome10.6
3autism spectrum disorder10.5
4micro syndrome10.5
5microcephaly10.4
6blepharophimosis intellectual disability syndromes10.4
7short stature10.4
8down syndrome10.4
9male pseudohermaphroditism intellectual disability syndrome, verloes type10.4
10williams syndrome10.3
11n syndrome10.3
12developmental disabilities10.3
13trichomegaly with intellectual disability, dwarfism and pigmentary degeneration of retina10.3
14x-linked intellectual disability-retinitis pigmentosa syndrome10.3
15bipolar i disorder10.3
16fragile x syndrome10.3
17bipolar disorder10.3
18attention deficit hyperactivity disorder10.2
19angelman syndrome10.2
20autistic disorder10.2
21phenylketonuria10.2
22kansl1-related intellectual disability syndrome10.2
23snyder-robinson syndrome10.2
24blepharophimosis-ptosis-intellectual disability syndrome10.2
25rett syndrome10.1
26williams-beuren syndrome10.1
27congenital hypothyroidism10.1
28wolf-hirschhorn syndrome10.1
29lennox-gastaut syndrome10.1
30west syndrome10.1
31succinic semialdehyde dehydrogenase deficiency10.1
32cleft palate10.1
33sleep disorder10.1
34kabuki syndrome10.1
35pitt-hopkins syndrome10.1
36short syndrome10.1
37pallister-killian mosaic syndrome10.1
38ring chromosome 1410.1
39potocki-shaffer syndrome10.1
40ppm-x syndrome10.1
41momo syndrome10.1
42oral cancer10.1
43koolen-de vries syndrome10.1
44hypotonia10.1
45spasticity10.1
46recessive intellectual disability - motor dysfunction - multiple joint contractures10.1
47congenital muscular dystrophy without intellectual disability10.1
48x-linked intellectual disability due to gria3 anomalies10.1
49colobomatous microphthalmia-obesity-hypogenitalism-intellectual disability syndrome10.1
50intellectual disability-brachydactyly-pierre robin syndrome10.1

Graphical network of the top 20 diseases related to Intellectual Disability:



Diseases related to intellectual disability

Clinical Features for Intellectual Disability

Sources:
47OMIM
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Clinical features from OMIM:

309583, 614202, 300436, 300387, 300849, 300486, 300210, 300844, 300143, 300558 613192 more

Clinical synopsis from OMIM:

614202

Drugs & Therapeutics for Intellectual Disability

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intellectual Disability

Drug clinical trials:

Search ClinicalTrials for Intellectual Disability

Search NIH Clinical Center for Intellectual Disability

Search CenterWatch for Intellectual Disability

Genetic Tests for Intellectual Disability

Sources:
20GeneTests, 22GTR
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Genetic tests related to Intellectual Disability:

id Genetic test Affiliating Genes
1 Intellectual Disability Multi-gene Panels20
2 Mental Retardation, Autosomal Recessive 1522

Anatomical Context for Intellectual Disability

Animal Models for Intellectual Disability or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Intellectual Disability

Sources:
51PubMed
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Articles related to Intellectual Disability:

(show top 50)    (show all 652)
idTitleAuthorsYear
1
Inhibition deficits in individuals with intellectual disability: a meta-regression analysis. (23902129)
2014
2
Eliciting perceptions of satisfaction with services and supports from persons with intellectual disability and developmental disabilities: a review of the literature. (24433252)
2014
3
Exome sequencing in a family with intellectual disability, early onset spasticity, and cerebellar atrophy detects a novel mutation in EXOSC3. (23975261)
2013
4
An Amino Acid Deletion inSZT2 in a Family with Non-Syndromic Intellectual Disability. (24324832)
2013
5
Mutations of the synapse genes and intellectual disability syndromes. (23872408)
2013
6
Recessive TRAPPC11 mutations cause a disease spectrum of limb girdle muscular dystrophy and myopathy with movement disorder and intellectual disability. (23830518)
2013
7
Homozygous deletion in TUSC3 causing syndromic intellectual disability: a new patient. (23825019)
2013
8
Genetics and the investigation of developmental delay/intellectual disability. (24344174)
2013
9
Effects of controlled discontinuation of long-term used antipsychotics on weight and metabolic parameters in individuals with intellectual disability. (23775048)
2013
10
Attributions, criticism and warmth in mothers of children with intellectual disability and challenging behaviour: a pilot study. (23464804)
2013
11
Evaluating a health behaviour model for persons with and without an intellectual disability. (23627702)
2013
12
Staff members of community services for people with intellectual disability and severe mental illness: values, attitudes, and burnout. (24025436)
2013
13
Menopause experiences and attitudes in women with intellectual disability and in their family carers. (23510003)
2013
14
Chromosomal microarray among children with intellectual disability: a useful diagnostic tool for the clinical geneticist. (24266756)
2013
15
Students' attitudes towards individuals with an intellectual disability. (24196840)
2013
16
Complete and pure trisomy 18p due to a complex chromosomal rearrangement in a male adult with mild intellectual disability. (23695988)
2013
17
Intellectual Disability, Mild Cognitive Impairment, and Risk for Dementia. (24273589)
2013
18
The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. (23821644)
2013
19
A novel in-frame deletion affecting the BAR domain of OPHN1 in a family with intellectual disability and hippocampal alterations. (24105372)
2013
20
Intelligence quotient is associated with epilepsy in children with intellectual disability in India. (24347947)
2013
21
Intellectual disability and co-occurring mental health and physical disorders in aggressive behaviour. (23952483)
2013
22
Parent education for adults with intellectual disability: A review and suggestions for future research. (24088181)
2013
23
Reliability of a method for establishing the capacity of individuals with an intellectual disability to respond to Likert scales. (24279784)
2013
24
The iconicity of picture communication symbols for children with english additional language and mild intellectual disability. (24229339)
2013
25
Pre-trial reported defendants in the Netherlands with intellectual disability, borderline and normal intellectual functioning. (23925958)
2013
26
Person-centred reviews as a mechanism for planning the post-school transition of young people with intellectual disability. (23796061)
2013
27
Infant's engagement and emotion as predictors of autism or intellectual disability in West syndrome. (23728914)
2013
28
Dysfunction of SHANK2 and CHRNA7 in a patient with intellectual disability and language impairment supports genetic epistasis of the two loci. (23350639)
2013
29
Train the trainer? A randomized controlled trial of a multi-tiered oral health education programme in community-based residential services for adults with intellectual disability. (23039926)
2013
30
Why do some people with intellectual disability engage in offending behaviour and what can we do about it? Editorial. (23925957)
2013
31
Agreement in quality of life assessment between adolescents with intellectual disability and their parents. (23584169)
2013
32
Self-reported versus informant-reported depressive symptoms in adults with mild intellectual disability. (23902265)
2013
33
Individuals with intellectual disability can self-teach in reading. (23464609)
2013
34
A novel de novo 1.8 Mb microdeletion of 17q21.33 associated with intellectual disability and dysmorphic features. (22842074)
2012
35
Alcohol and intellectual disability: personal problem or cultural exclusion? (22821896)
2012
36
Predictors of visual-motor integration in children with intellectual disability. (23032939)
2012
37
Reliability and validity of the Dutch version of the Glasgow Anxiety Scale for people with an Intellectual Disability (GAS-ID). (23046166)
2012
38
Post-electroconvulsive therapy status epilepticus and tardive seizure in a patient with rapid cycling bipolar disorder, epilepsy, and intellectual disability. (22868490)
2012
39
Aphonia, microstomia, deafness, retinal dystrophy, duplicated halluces and intellectual disability. (22991300)
2012
40
A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections. (22909152)
2012
41
Service development for intellectual disability mental health: a human rights approach. (23106753)
2012
42
Behavioral features of Williams Beuren syndrome compared to Fragile X syndrome and subjects with intellectual disability without defined etiology. (21211940)
2011
43
Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability. (21609749)
2011
44
Absence seizures with intellectual disability as a phenotype of the 15q13.3 microdeletion syndrome. (22050399)
2011
45
Deletion in Xp22.11: PTCHD1 is a candidate gene for X-linked intellectual disability with or without autism. (21091464)
2011
46
The serum level of interleukin-6 in patients with intellectual disability and refractory epilepsy. (21530175)
2011
47
SOBP is mutated in syndromic and nonsyndromic intellectual disability and is highly expressed in the brain limbic system. (21035105)
2010
48
Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. (20844286)
2010
49
Comments on: M. Zigmond et al. (2006) The outcome of a preventive dental care programme on the prevalence of localized aggressive periodontitis in Down's syndrome (DS) individuals (Journal of Intellectual Disability Research, 50(7), pp. 492-500). (18173577)
2008
50
Vitamin B12 deficiency in persons with intellectual disability in a vegetarian residential care community. (15674451)
2005

Genetic Variations for Intellectual Disability

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Intellectual Disability:

63
id Symbol AA change Variation SNP ID
1MAN1B1p.Arg334CysVAR_066592
2MAN1B1p.Glu397LysVAR_066593

Expression for genes affiliated with Intellectual Disability

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intellectual Disability

Search GEO for disease gene expression data for Intellectual Disability.

Pathways for genes affiliated with Intellectual Disability

Compounds for genes affiliated with Intellectual Disability

GO Terms for genes affiliated with Intellectual Disability

Products for genes affiliated with Intellectual Disability

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Sources for Intellectual Disability

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet