MCID: INT007
MIFTS: 47

Intermediate Coronary Syndrome malady

Cardiovascular diseases category

Summaries for Intermediate Coronary Syndrome

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MalaCards based summary: Intermediate Coronary Syndrome, also known as myocardial preinfarction syndrome, is related to coronary thrombosis and congestive heart failure. An important gene associated with Intermediate Coronary Syndrome is AMH (anti-Mullerian hormone), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The drugs heparin and heparin sodium and the compounds microplasmin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Intermediate Coronary Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Intermediate Coronary Syndrome, Aliases & Descriptions:

Name: Intermediate Coronary Syndrome 9 11
Myocardial Preinfarction Syndrome 60
Anginal Chest Pain at Rest 9
Preinfarction Syndrome 9
Preinfarction Angina 9
Impending Infarction 9
Angina: Crescendo 9
Worsening Angina 9
 
Crescendo Angina 43
Angina, Unstable 60
Angina Decubitus 60
Unstable Angina 9
Angina at Rest 9
Unstable 9
at Rest 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Intermediate Coronary Syndrome

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Diseases related to Intermediate Coronary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1coronary thrombosis30.8SERPINC1, PLAT
2congestive heart failure30.7TNNT2, TNNI3
3thrombocytosis30.3PF4, SERPINC1
4atrial fibrillation30.2PF4, PLAT
5ischemia30.2MB, PIK3C2A, PLG, PLAT, PF4, TNNT2
6antiphospholipid syndrome30.1SERPINC1, PLAT, PF4
7coronary artery disease30.1PF4, MB, PLG, PIK3C2A, ITGA2B, PLAT
8respiratory failure29.9PIK3C2A, SERPINC1
9dilated cardiomyopathy29.7MB, TNNI3, PIK3C2A, TNNT2
10myopathy29.7MB, PIK3C2A, TNNI3, TNNT2
11atherosclerosis29.6MB, PLAT, PLG, SERPINC1, PF4, ITGA2B
12vascular disease29.3SERPINC1, PIK3C2A, TNNI3, MB, PF4, TNNT2
13acute myocardial infarction28.4SERPINC1, MB, PLG, PLAT, ITGA2B, PF4
14myocardial infarction28.2PIK3C2A, TNNT2, TNNI3, SERPINC1, AMH, PF4
15endotheliitis10.6
16artery disease10.6
17acute poststreptococcal glomerulonephritis10.5PF4
18coronary stenosis10.5
19blindness10.5
20cor pulmonale10.4
21central retinal artery occlusion10.4PLAT
22central retinal vein occlusion10.4PLAT
23myocardial stunning10.4
24pneumonia10.4
25prinzmetal's variant angina10.4
26spontaneous coronary artery dissection10.4
27diabetic ketoacidosis10.4PIK3C2A
28malaria10.3MB
29restrictive cardiomyopathy10.3TNNI3, TNNT2
30subendocardial myocardial infarction10.3
31subclavian steal syndrome10.3
32essential thrombocythemia10.3
33corneal neovascularization10.3PF4, PLG
34glanzmann thrombasthenia10.3PF4, ITGA2B
35retinal vein occlusion10.3SERPINC1
36sneddon syndrome10.3SERPINC1
37sudden cardiac death multi-gene panels10.3TNNT2, TNNI3
38intermittent claudication10.3
39purpura10.3SERPINC1
40hypertrophic cardiomyopathy10.3TNNI3, TNNT2
41intracranial thrombosis10.2PLG, PLAT
42schizophrenia10.2
43cerebritis10.2
44spinocerebellar ataxia10.2TNNT2, MB
45gas gangrene10.2TNNT2, PIK3C2A
46peripheral vascular disease10.2
47ischemic heart disease10.2
48renovascular hypertension10.2
49rheumatic fever10.2
50pituitary apoplexy10.2

Graphical network of the top 20 diseases related to Intermediate Coronary Syndrome:



Diseases related to intermediate coronary syndrome

Symptoms for Intermediate Coronary Syndrome

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Drugs & Therapeutics for Intermediate Coronary Syndrome

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Genetic Tests for Intermediate Coronary Syndrome

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Anatomical Context for Intermediate Coronary Syndrome

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MalaCards organs/tissues related to Intermediate Coronary Syndrome:

31
Lung

Animal Models for Intermediate Coronary Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Intermediate Coronary Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5PLG, PLAT, ITGA2B, AMH, SERPINC1
2MP:00053857.7TNNT2, TNNI3, SERPINC1, ITGA2B, PLAT, PLG
3MP:00053977.1PIK3C2A, SERPINC1, PF4, ITGA2B, PLAT, PLG
4MP:00053766.7MB, PIK3C2A, TNNT2, SERPINC1, AMH, PF4
5MP:00107686.4PIK3C2A, TNNT2, TNNI3, SERPINC1, PLAT, PLG

Publications for Intermediate Coronary Syndrome

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Articles related to Intermediate Coronary Syndrome:

(show all 21)
idTitleAuthorsYear
1
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention. (11076127)
2000
2
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. (2136815)
1990
3
Atenolol, heparin and the intermediate coronary syndrome. (6113419)
1981
4
Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. (6112564)
1981
5
The intermediate coronary syndrome. (6971456)
1981
6
Pathophysiologic significance of S-T and T wave abnormalities in patients with the intermediate coronary syndrome. (299974)
1977
7
Long-term follow-up in patients receiving emergency revascularization for intermediate coronary syndrome. (4600203)
1974
8
SURGICAL MANAGEMENT OF THE INTERMEDIATE CORONARY SYNDROME. (15215960)
1974
9
Editorial: Intermediate coronary syndrome. (4148257)
1973
10
Bradycardia in intermediate coronary syndrome. (4723578)
1973
11
The natural history of intermediate coronary syndrome. (4721961)
1973
12
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects. (4144755)
1973
13
Letter: Intermediate coronary syndrome. (4752330)
1973
14
Early diagnosis of acute myocardial infarction with special reference to the diagnosis of the intermediate coronary syndrome. A clinical study. (4586014)
1972
15
Recognition and management of the intermediate coronary syndrome. (6021604)
1967
16
Diagnosis and management of the intermediate coronary syndrome. A clinical study of 400 cases of the syndrome. (5932254)
1966
17
THE INTERMEDIATE CORONARY SYNDROME. (14061336)
1963
18
Intermediate coronary syndrome. (13779654)
1961
19
Electrocardiographic changes in the intermediate coronary syndrome. II. Location of lesions. (13286446)
1956
20
The intermediate coronary syndrome. (13226558)
1955
21
I. Electrocardiographic changes in the intermediate coronary syndrome. (13211952)
1954

Variations for Intermediate Coronary Syndrome

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Expression for genes affiliated with Intermediate Coronary Syndrome

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Search GEO for disease gene expression data for Intermediate Coronary Syndrome.

Pathways for genes affiliated with Intermediate Coronary Syndrome

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Compounds for genes affiliated with Intermediate Coronary Syndrome

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Compounds related to Intermediate Coronary Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1microplasmin439.9PLAT, PLG
2integrilin439.9PLAT, SERPINC1
3reviparin439.9PLAT, SERPINC1
4alpha-hydroxybutyrate439.9PIK3C2A, MB
5efegatran439.9SERPINC1, PLAT
6spectrozyme439.8SERPINC1, PLAT
7eaca439.7SERPINC1, PLAT
8polybrene439.7SERPINC1, PF4
9p-amino benzamidine439.6PLAT, SERPINC1
10danaparoid439.6PF4, SERPINC1
11ancrod439.6SERPINC1, PLAT
12tranexamic acid43 1210.5PLG, PLAT, SERPINC1
13epsilon aminocaproic acid439.5PLAT, SERPINC1, PLG
14isopropanol439.5PF4, MB
15fluvastatin43 49 28 1212.4MB, PIK3C2A, PLAT
16fibrinopeptide a439.3SERPINC1, PF4, PLAT
17fondaparinux439.3PF4, SERPINC1, PLAT
18protamine sulfate439.3SERPINC1, PF4, PLAT
19ticlopidine43 1210.3SERPINC1, PLAT, PF4
20iloprost59 28 43 1212.3SERPINC1, PLAT, PF4
21protamine439.3SERPINC1, PLAT, PF4
22dermatan sulfate439.2PF4, SERPINC1, PLAT
23tamoxifen43 49 28 1212.2SERPINC1, AMH, PLAT, PLG
24polyethylene glycol439.2PF4, MB, SERPINC1
25thromboxane43 2410.2PF4, PIK3C2A, PLAT
26pge1439.1PLAT, PF4, PIK3C2A
27thromboxane a243 2410.1PLAT, PF4, PIK3C2A
28tirofiban43 1210.0ITGA2B, SERPINC1, PF4, PLAT
29abciximab43 1210.0PLAT, ITGA2B, SERPINC1, PF4
30homocysteine43 2410.0PLAT, SERPINC1, PIK3C2A
31ascorbic acid43 249.9MB, PIK3C2A, PLAT, SERPINC1
32kininogen438.9PLG, SERPINC1, PF4, PLAT
33ptca438.9TNNT2, PLAT, PF4, PIK3C2A
34citrate438.9PIK3C2A, SERPINC1, PF4, MB
35nicotine43 28 49 1211.9SERPINC1, PLAT, MB, PF4
36hirudin438.8PIK3C2A, SERPINC1, PF4, PLAT
37warfarin43 49 24 1211.8PIK3C2A, SERPINC1, PF4, PLAT
38prostacyclin438.8PIK3C2A, SERPINC1, PLAT, PF4
39sodium nitroprusside438.7PIK3C2A, PLAT, MB
40estradiol43 24 1210.7AMH, PIK3C2A, PLAT, PF4
41lactate438.7PIK3C2A, TNNT2, PF4, MB, TNNI3
42lysine438.5PF4, ITGA2B, PLAT, PLG
43aprotinin43 129.5PLAT, PLG, SERPINC1, MB, PF4
44alanine438.4MB, PIK3C2A, SERPINC1, PF4, TNNT2
45vegf438.4SERPINC1, MB, PIK3C2A, PLG, PF4
46adp43 28 2410.3SERPINC1, ITGA2B, PLAT, PF4, PIK3C2A
47cysteine438.2MB, PLG, ITGA2B, PLAT, PF4
48fibrinogen438.1PIK3C2A, PLG, PLAT, ITGA2B, PF4, SERPINC1
49creatinine437.7PLAT, PF4, MB, TNNI3, TNNT2, SERPINC1
50heparin43 28 24 1210.7PIK3C2A, PLG, MB, PLAT, PF4, SERPINC1

GO Terms for genes affiliated with Intermediate Coronary Syndrome

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Cellular components related to Intermediate Coronary Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:00058619.9TNNI3, TNNT2
2sarcomereGO:00300179.5TNNI3, TNNT2
3platelet alpha granule lumenGO:00310939.5PLG, PF4
4blood microparticleGO:00725629.3SERPINC1, ITGA2B, PLG
5extracellular spaceGO:00056158.3PLG, PLAT, PF4, AMH, SERPINC1
6extracellular regionGO:00055768.1SERPINC1, AMH, PF4, PLAT, PLG

Biological processes related to Intermediate Coronary Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:00327809.9TNNT2, TNNI3
2muscle filament slidingGO:00300499.8TNNI3, TNNT2
3ventricular cardiac muscle tissue morphogenesisGO:00550109.7TNNT2, TNNI3
4fibrinolysisGO:00427309.6PLAT, PLG
5platelet degranulationGO:00025769.3PF4, ITGA2B, PLG
6platelet activationGO:00301689.2PLG, ITGA2B, PF4
7platelet-derived growth factor receptor signaling pathwayGO:00480089.1PIK3C2A, PLAT
8blood coagulationGO:00075968.4PLG, PLAT, ITGA2B, PF4, SERPINC1

Molecular functions related to Intermediate Coronary Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:00301729.8TNNI3, TNNT2

Products for genes affiliated with Intermediate Coronary Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Intermediate Coronary Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet