MCID: INT007
MIFTS: 53

Intermediate Coronary Syndrome malady

Cardiovascular diseases category

Summaries for Intermediate Coronary Syndrome

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32MalaCards
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MalaCards: Intermediate Coronary Syndrome, also known as myocardial preinfarction syndrome, is related to ischemia and coronary thrombosis. An important gene associated with Intermediate Coronary Syndrome is AMH (anti-Mullerian hormone), and among its related pathways are Dissolution of Fibrin Clot and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs heparin and heparin sodium and the compounds reviparin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Intermediate Coronary Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

intermediate coronary syndrome 8 10
myocardial preinfarction syndrome 60
anginal chest pain at rest 8
preinfarction syndrome 8
impending infarction 8
preinfarction angina 8
angina: crescendo 8
worsening angina 8
angina, unstable 60
crescendo angina 44
unstable angina 8
angina at rest 8
unstable 8
at rest 8


Related Diseases for Intermediate Coronary Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intermediate Coronary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.9MB, TNNT2, PIK3C2A, PF4, PLG, PLAT
2coronary thrombosis30.7PLAT, SERPINC1
3coronary artery disease30.6MB, PIK3C2A, ITGA2B, PF4, PLG, PLAT
4malaria30.5MB
5pneumonia30.5PIK3C2A, MB
6atherosclerosis30.4MB, ITGA2B, PF4, PLG, PLAT, ACE
7myocardial infarction30.4AMH, UBAP1, MB, TNNT2, TNNI3, PIK3C2A
8hypertension30.3ACE, PLAT, PLG
9diabetes mellitus30.3PIK3C2A, ITGA2B, PF4, PLG, PLAT, ACE
10acute myocardial infarction30.2ITGA2B, PF4, PLG, PLAT, ACE, PAPPA
11essential hypertension30.2ACE, PLAT, PF4
12pulmonary embolism30.2PF4, PLG, PLAT, SERPINC1
13congestive heart failure30.1TNNT2, TNNI3
14peripheral vascular disease30.1PF4, ACE
15antiphospholipid syndrome30.1PF4, PLAT, SERPINC1
16intermittent claudication30.1PF4
17vascular disease30.1PLAT, ACE, SERPINC1
18arteriosclerosis obliterans30.1PF4
19ischemic heart disease30.1MB, TNNT2, TNNI3, PIK3C2A, PF4, PLG
20leukemia30.0PLG, PF4, ITGA2B
21adenocarcinoma29.9PLG, PF4
22arthritis29.9PLG, MB
23stroke, ischemic29.9SERPINC1, PLAT, PF4
24respiratory failure29.9PIK3C2A, SERPINC1
25thrombocytopenia29.8PIK3C2A, ITGA2B, PF4, PLG, SERPINC1
26dilated cardiomyopathy29.8MB, TNNT2, TNNI3, PIK3C2A, ACE
27peritonitis29.7MB
28eclampsia29.6SERPINC1
29galactosemia29.6SERPINC1
30hypothyroidism29.6PIK3C2A
31carotid artery disease29.6PLAT
32rheumatoid arthritis29.6PLG, PF4, MB
33neuroleptic malignant syndrome29.6MB, PIK3C2A
34pre-eclampsia29.6SERPINC1, PAPPA, PLAT
35colorectal cancer10.5
36coronary stenosis10.5
37chronic angina10.3
38myocardial stunning10.3
39hemolytic anemia10.3
40colon cancer10.3
41thalassemia10.3
42subclavian steal syndrome10.2
43subendocardial myocardial infarction10.2
44alpha thalassemia10.2
45osteochondritis dissecans10.2
46plasmodium malariae malaria10.2
47spondylolisthesis10.2
48plasmodium falciparum malaria10.2
49spinocerebellar ataxia10.2
50myotonic dystrophy10.2

Graphical network of the top 20 diseases related to Intermediate Coronary Syndrome:



Diseases related to intermediate coronary syndrome

Clinical Features for Intermediate Coronary Syndrome

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Drugs & Therapeutics for Intermediate Coronary Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intermediate Coronary Syndrome

Drug clinical trials:

Search ClinicalTrials for Intermediate Coronary Syndrome

Search NIH Clinical Center for Intermediate Coronary Syndrome

Search CenterWatch for Intermediate Coronary Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Intermediate Coronary Syndrome

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Anatomical Context for Intermediate Coronary Syndrome

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32MalaCards
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MalaCards organs/tissues related to Intermediate Coronary Syndrome:

32
Lung

Animal Models for Intermediate Coronary Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intermediate Coronary Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.3SERPINC1, ACE, PLAT, PLG, ITGA2B, AMH
2MP:00053857.7MB, TNNT2, TNNI3, ITGA2B, PLG, PLAT
3MP:00053977.0MB, PIK3C2A, ITGA2B, PF4, PLAT, ACE
4MP:00107686.5UBAP1, MB, TNNT2, TNNI3, PIK3C2A, PLG
5MP:00053766.5SERPINC1, AMH, MB, TNNT2, PIK3C2A, ITGA2B

Publications for Intermediate Coronary Syndrome

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50PubMed
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Articles related to Intermediate Coronary Syndrome:

(show all 22)
idTitleAuthorsYear
1
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention. (11076127)
2000
2
A prospective study of an algorithm using cardiac troponin I and myoglobin as adjuncts in the diagnosis of acute myocardial infarction and intermediate coronary syndromes in a veteran's hospital. (11129678)
2000
3
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. (2136815)
1990
4
Atenolol, heparin and the intermediate coronary syndrome. (6113419)
1981
5
Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. (6112564)
1981
6
The intermediate coronary syndrome. (6971456)
1981
7
Pathophysiologic significance of S-T and T wave abnormalities in patients with the intermediate coronary syndrome. (299974)
1977
8
Long-term follow-up in patients receiving emergency revascularization for intermediate coronary syndrome. (4600203)
1974
9
SURGICAL MANAGEMENT OF THE INTERMEDIATE CORONARY SYNDROME. (15215960)
1974
10
Editorial: Intermediate coronary syndrome. (4148257)
1973
11
Bradycardia in intermediate coronary syndrome. (4723578)
1973
12
The natural history of intermediate coronary syndrome. (4721961)
1973
13
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects. (4144755)
1973
14
Letter: Intermediate coronary syndrome. (4752330)
1973
15
Early diagnosis of acute myocardial infarction with special reference to the diagnosis of the intermediate coronary syndrome. A clinical study. (4586014)
1972
16
Recognition and management of the intermediate coronary syndrome. (6021604)
1967
17
Diagnosis and management of the intermediate coronary syndrome. A clinical study of 400 cases of the syndrome. (5932254)
1966
18
THE INTERMEDIATE CORONARY SYNDROME. (14061336)
1963
19
Intermediate coronary syndrome. (13779654)
1961
20
Electrocardiographic changes in the intermediate coronary syndrome. II. Location of lesions. (13286446)
1956
21
The intermediate coronary syndrome. (13226558)
1955
22
I. Electrocardiographic changes in the intermediate coronary syndrome. (13211952)
1954

Genetic Variations for Intermediate Coronary Syndrome

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Expression for genes affiliated with Intermediate Coronary Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermediate Coronary Syndrome

Search GEO for disease gene expression data for Intermediate Coronary Syndrome.

Pathways for genes affiliated with Intermediate Coronary Syndrome

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Sources:
53Reactome, 12EMD Millipore, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Intermediate Coronary Syndrome

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1reviparin4410.0PLAT, SERPINC1
2integrilin4410.0SERPINC1, PLAT
3Aminocaproic Acid1110.0PLAT, PLG
4efegatran4410.0PLAT, SERPINC1
5microplasmin4410.0PLG, PLAT
6delapril4410.0ACE, PLAT
7manidipine449.9ACE, PLAT
8spectrozyme449.8SERPINC1, PLAT
9tranexamic acid44 1110.8SERPINC1, PLG, PLAT
10epsilon aminocaproic acid449.8SERPINC1, PLAT, PLG
11polybrene449.6PF4, SERPINC1
12diltiazem44 28 1111.6ACE, PLAT, SERPINC1
13clopidogrel49 44 11 2412.6PLAT, ACE, SERPINC1
14fibrinopeptide a449.6PF4, SERPINC1, PLAT
15eaca449.6SERPINC1, PLAT
16fondaparinux449.6SERPINC1, PLAT, PF4
17protamine sulfate449.6PF4, SERPINC1, PLAT
18ticlopidine44 1110.6SERPINC1, PLAT, PF4
19alpha-hydroxybutyrate449.6PIK3C2A, MB
20iloprost44 59 28 1112.5PLAT, SERPINC1, PF4
21protamine449.5PLAT, PF4, SERPINC1
22dermatan sulfate449.4PLAT, SERPINC1, PF4
23aprotinin44 1110.3PF4, SERPINC1, PLAT, MB
24tirofiban44 1110.3ITGA2B, PF4, PLAT, SERPINC1
25abciximab44 1110.3ITGA2B, PF4, PLAT, SERPINC1
26danaparoid449.3SERPINC1, PF4
27estradiol44 11 2411.3PAPPA, AMH, PIK3C2A
28nicotine44 49 28 1112.3MB, PF4, PLAT, SERPINC1
29warfarin44 49 11 2412.2SERPINC1, PF4, PIK3C2A
30nitroglycerin44 1110.1PLAT, PIK3C2A, ACE
31fluvastatin44 49 28 1112.1PLAT, MB, PIK3C2A
32tamoxifen44 49 28 1112.1AMH, SERPINC1, PLAT, PLG
33heparan sulfate44 2410.0PF4, PLAT, PAPPA, SERPINC1
34aspirin44 49 28 2412.0SERPINC1, ACE, PLAT, PF4
35thromboxane44 249.9PIK3C2A, PF4, PLAT
36citrate448.9PIK3C2A, SERPINC1, MB, PF4
37ptca448.8PF4, PIK3C2A, TNNT2, PLAT
38kininogen448.8SERPINC1, ACE, PLAT, PLG, PF4
39hirudin448.8PIK3C2A, PLAT, SERPINC1, PF4
40lysine448.7PAPPA, PLAT, ITGA2B, PF4, PLG
41lactate448.6TNNT2, TNNI3, PIK3C2A, PF4, MB
42ascorbic acid44 249.6MB, SERPINC1, PIK3C2A, PLAT
43cysteine448.3PAPPA, PLAT, MB, ITGA2B, PLG, PF4
44prostacyclin448.3SERPINC1, PIK3C2A, PF4, PLAT, ACE
45fibrinogen448.1PLG, ITGA2B, PIK3C2A, PLAT, SERPINC1, PF4
46heparin44 28 11 2411.1TNNT2, PAPPA, PLG, PF4, PIK3C2A, MB
47vegf448.0MB, PIK3C2A, PAPPA, PF4, SERPINC1, PLG
48glucose447.6PAPPA, ACE, PLAT, PLG, PIK3C2A, PF4
49calcium44 49 11 2410.2PF4, PLG, PAPPA, ITGA2B, PIK3C2A, ACE
50creatinine446.9TNNI3, TNNT2, PIK3C2A, PF4, PLAT, ACE

GO Terms for genes affiliated with Intermediate Coronary Syndrome

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16Gene Ontology
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Cellular components related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.9TNNI3, TNNT2
2extracellular spaceGO:0056157.5SERPINC1, AMH, PF4, PLG, PLAT, ACE
3extracellular regionGO:0055767.3AMH, PF4, PLG, PLAT, ACE, PAPPA

Biological processes related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.0TNNI3, TNNT2
2ventricular cardiac muscle tissue morphogenesisGO:0550109.9TNNI3, TNNT2
3fibrinolysisGO:0427309.6PLAT, PLG
4platelet degranulationGO:0025769.3ITGA2B, PF4, PLG
5platelet-derived growth factor receptor signaling pathwayGO:0480088.9PLAT, PIK3C2A
6blood coagulationGO:0075968.6SERPINC1, PLAT, PLG, PF4, ITGA2B

Molecular functions related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:0301729.6TNNI3, TNNT2
2endopeptidase activityGO:0041759.5PAPPA, ACE

Products for genes affiliated with Intermediate Coronary Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermediate Coronary Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet