MCID: INT007
MIFTS: 57

Intermediate Coronary Syndrome malady

Cardiovascular diseases category
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Summaries for Intermediate Coronary Syndrome

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MalaCards based summary: Intermediate Coronary Syndrome, also known as anginal chest pain at rest, is related to coronary thrombosis and congestive heart failure. An important gene associated with Intermediate Coronary Syndrome is AMH (anti-Mullerian hormone), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The drugs heparin and heparin sodium and the compounds microplasmin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Intermediate Coronary Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 44Novoseek, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Intermediate Coronary Syndrome, Aliases & Descriptions:

Name: Intermediate Coronary Syndrome 8 10 62
Anginal Chest Pain at Rest 8 62
Impending Infarction 8 62
Angina at Rest 8 62
Myocardial Preinfarction Syndrome 62
Preinfarction Syndrome 8
Angina, Preinfarction 62
Preinfarction Angina 8
 
Angina: Crescendo 8
Crescendo Angina 44
Angina, Unstable 62
Worsening Angina 8
Unstable Angina 8
Unstable 8
at Rest 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Intermediate Coronary Syndrome

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Diseases related to Intermediate Coronary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1coronary thrombosis30.8PLAT, SERPINC1
2congestive heart failure30.7TNNT2, TNNI3
3thrombocytosis30.3SERPINC1, PF4
4ischemia30.2PIK3C2A, TNNT2, PF4, PLAT, PLG, MB
5antiphospholipid syndrome30.1PLAT, PF4, SERPINC1
6respiratory failure29.9SERPINC1, PIK3C2A
7dilated cardiomyopathy29.7PIK3C2A, TNNT2, TNNI3, MB
8myopathy29.7MB, TNNI3, TNNT2, PIK3C2A
9atherosclerosis29.6SERPINC1, PF4, ITGA2B, PLAT, PLG, MB
10diabetes mellitus29.4PIK3C2A, SERPINC1, PF4, ITGA2B, PLAT, PLG
11vascular disease29.3PIK3C2A, TNNT2, TNNI3, SERPINC1, PF4, MB
12acute myocardial infarction28.6PIK3C2A, TNNT2, TNNI3, SERPINC1, PF4, ITGA2B
13myocardial infarction28.3SERPINC1, AMH, PF4, ITGA2B, PLAT, PLG
14endotheliitis10.6
15artery disease10.5
16acute poststreptococcal glomerulonephritis10.5PF4
17coronary stenosis10.4
18prinzmetal's variant angina10.4
19blindness10.4
20cor pulmonale10.4
21central retinal artery occlusion10.4PLAT
22central retinal vein occlusion10.4PLAT
23myocardial stunning10.4
24pneumonia10.4
25spontaneous coronary artery dissection10.4
26diabetic ketoacidosis10.4PIK3C2A
27malaria10.3MB
28familial restrictive cardiomyopathy10.3TNNI3, TNNT2
29hypertension10.3
30subendocardial myocardial infarction10.3
31subclavian steal syndrome10.3
32essential thrombocythemia10.3
33glanzmann's thrombasthenia10.3ITGA2B, PF4
34corneal neovascularization10.3PF4, PLG
35retinal vein occlusion10.3SERPINC1
36familial hypertrophic cardiomyopathy10.3TNNI3, TNNT2
37sneddon syndrome10.3SERPINC1
38sudden cardiac death multi-gene panels10.3TNNI3, TNNT2
39purpura10.3SERPINC1
40hypertrophic cardiomyopathy10.3TNNT2, TNNI3
41intracranial thrombosis10.2PLAT, PLG
42schizophrenia10.2
43cerebritis10.2
44essential hypertension10.2
45gas gangrene10.2PIK3C2A, TNNT2
46cardiogenic shock10.2PIK3C2A, PLAT
47creatine phosphokinase, elevated serum10.2PIK3C2A, MB
48peripheral vascular disease10.1
49hodgkin's lymphoma10.1
50ischemic heart disease10.1

Graphical network of the top 20 diseases related to Intermediate Coronary Syndrome:



Diseases related to intermediate coronary syndrome

Symptoms for Intermediate Coronary Syndrome

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Drugs & Therapeutics for Intermediate Coronary Syndrome

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Genetic Tests for Intermediate Coronary Syndrome

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Anatomical Context for Intermediate Coronary Syndrome

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MalaCards organs/tissues related to Intermediate Coronary Syndrome:

32
Lung

Animal Models for Intermediate Coronary Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Intermediate Coronary Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5PLG, PLAT, ITGA2B, AMH, SERPINC1
2MP:00053857.7TNNT2, TNNI3, SERPINC1, ITGA2B, PLAT, PLG
3MP:00053977.1PIK3C2A, SERPINC1, PF4, ITGA2B, PLAT, PLG
4MP:00053766.7MB, PIK3C2A, TNNT2, SERPINC1, AMH, PF4
5MP:00107686.4PIK3C2A, TNNT2, TNNI3, SERPINC1, PLAT, PLG

Publications for Intermediate Coronary Syndrome

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Articles related to Intermediate Coronary Syndrome:

(show all 22)
idTitleAuthorsYear
1
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention. (11076127)
2000
2
A prospective study of an algorithm using cardiac troponin I and myoglobin as adjuncts in the diagnosis of acute myocardial infarction and intermediate coronary syndromes in a veteran's hospital. (11129678)
2000
3
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. (2136815)
1990
4
Atenolol, heparin and the intermediate coronary syndrome. (6113419)
1981
5
Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. (6112564)
1981
6
The intermediate coronary syndrome. (6971456)
1981
7
Pathophysiologic significance of S-T and T wave abnormalities in patients with the intermediate coronary syndrome. (299974)
1977
8
Long-term follow-up in patients receiving emergency revascularization for intermediate coronary syndrome. (4600203)
1974
9
SURGICAL MANAGEMENT OF THE INTERMEDIATE CORONARY SYNDROME. (15215960)
1974
10
Editorial: Intermediate coronary syndrome. (4148257)
1973
11
Bradycardia in intermediate coronary syndrome. (4723578)
1973
12
The natural history of intermediate coronary syndrome. (4721961)
1973
13
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects. (4144755)
1973
14
Letter: Intermediate coronary syndrome. (4752330)
1973
15
Early diagnosis of acute myocardial infarction with special reference to the diagnosis of the intermediate coronary syndrome. A clinical study. (4586014)
1972
16
Recognition and management of the intermediate coronary syndrome. (6021604)
1967
17
Diagnosis and management of the intermediate coronary syndrome. A clinical study of 400 cases of the syndrome. (5932254)
1966
18
THE INTERMEDIATE CORONARY SYNDROME. (14061336)
1963
19
Intermediate coronary syndrome. (13779654)
1961
20
Electrocardiographic changes in the intermediate coronary syndrome. II. Location of lesions. (13286446)
1956
21
The intermediate coronary syndrome. (13226558)
1955
22
I. Electrocardiographic changes in the intermediate coronary syndrome. (13211952)
1954

Variations for Intermediate Coronary Syndrome

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Expression for genes affiliated with Intermediate Coronary Syndrome

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Expression patterns in normal tissues for genes affiliated with Intermediate Coronary Syndrome

Search GEO for disease gene expression data for Intermediate Coronary Syndrome.

Pathways for genes affiliated with Intermediate Coronary Syndrome

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Compounds for genes affiliated with Intermediate Coronary Syndrome

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Compounds related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1microplasmin449.9PLAT, PLG
2integrilin449.9PLAT, SERPINC1
3reviparin449.9PLAT, SERPINC1
4alpha-hydroxybutyrate449.9PIK3C2A, MB
5efegatran449.9SERPINC1, PLAT
6spectrozyme449.8SERPINC1, PLAT
7eaca449.7SERPINC1, PLAT
8polybrene449.7SERPINC1, PF4
9p-amino benzamidine449.6PLAT, SERPINC1
10danaparoid449.6PF4, SERPINC1
11ancrod449.6SERPINC1, PLAT
12tranexamic acid44 1110.5PLG, PLAT, SERPINC1
13epsilon aminocaproic acid449.5PLAT, SERPINC1, PLG
14isopropanol449.5PF4, MB
15fluvastatin44 50 28 1112.4MB, PIK3C2A, PLAT
16fibrinopeptide a449.3SERPINC1, PF4, PLAT
17fondaparinux449.3PF4, SERPINC1, PLAT
18protamine sulfate449.3SERPINC1, PF4, PLAT
19ticlopidine44 1110.3SERPINC1, PLAT, PF4
20iloprost61 28 44 1112.3SERPINC1, PLAT, PF4
21protamine449.3SERPINC1, PLAT, PF4
22dermatan sulfate449.2PF4, SERPINC1, PLAT
23tamoxifen44 50 28 1112.2SERPINC1, AMH, PLAT, PLG
24polyethylene glycol449.2PF4, MB, SERPINC1
25thromboxane44 2410.2PF4, PIK3C2A, PLAT
26pge1449.1PLAT, PF4, PIK3C2A
27thromboxane a244 2410.1PLAT, PF4, PIK3C2A
28tirofiban44 1110.0ITGA2B, SERPINC1, PF4, PLAT
29abciximab44 1110.0PLAT, ITGA2B, SERPINC1, PF4
30homocysteine44 2410.0PLAT, SERPINC1, PIK3C2A
31ascorbic acid44 249.9MB, PIK3C2A, PLAT, SERPINC1
32kininogen448.9PLG, SERPINC1, PF4, PLAT
33ptca448.9TNNT2, PLAT, PF4, PIK3C2A
34citrate448.9PIK3C2A, SERPINC1, PF4, MB
35nicotine44 28 50 1111.9SERPINC1, PLAT, MB, PF4
36hirudin448.8PIK3C2A, SERPINC1, PF4, PLAT
37warfarin44 50 24 1111.8PIK3C2A, SERPINC1, PF4, PLAT
38prostacyclin448.8PIK3C2A, SERPINC1, PLAT, PF4
39sodium nitroprusside448.7PIK3C2A, PLAT, MB
40estradiol44 24 1110.7AMH, PIK3C2A, PLAT, PF4
41lactate448.7PIK3C2A, TNNT2, PF4, MB, TNNI3
42lysine448.5PF4, ITGA2B, PLAT, PLG
43aprotinin44 119.5PLAT, PLG, SERPINC1, MB, PF4
44alanine448.4MB, PIK3C2A, SERPINC1, PF4, TNNT2
45vegf448.4SERPINC1, MB, PIK3C2A, PLG, PF4
46adp44 28 2410.3SERPINC1, ITGA2B, PLAT, PF4, PIK3C2A
47cysteine448.2MB, PLG, ITGA2B, PLAT, PF4
48fibrinogen448.1PIK3C2A, PLG, PLAT, ITGA2B, PF4, SERPINC1
49creatinine447.7PLAT, PF4, MB, TNNI3, TNNT2, SERPINC1
50heparin44 28 24 1110.7PIK3C2A, PLG, MB, PLAT, PF4, SERPINC1

GO Terms for genes affiliated with Intermediate Coronary Syndrome

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Cellular components related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.9TNNI3, TNNT2
2sarcomereGO:0300179.5TNNI3, TNNT2
3platelet alpha granule lumenGO:0310939.5PLG, PF4
4blood microparticleGO:0725629.3SERPINC1, ITGA2B, PLG
5extracellular spaceGO:0056158.3PLG, PLAT, PF4, AMH, SERPINC1
6extracellular regionGO:0055768.1SERPINC1, AMH, PF4, PLAT, PLG

Biological processes related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:0327809.9TNNT2, TNNI3
2muscle filament slidingGO:0300499.8TNNI3, TNNT2
3ventricular cardiac muscle tissue morphogenesisGO:0550109.7TNNT2, TNNI3
4fibrinolysisGO:0427309.6PLAT, PLG
5platelet degranulationGO:0025769.3PF4, ITGA2B, PLG
6platelet activationGO:0301689.2PLG, ITGA2B, PF4
7platelet-derived growth factor receptor signaling pathwayGO:0480089.1PIK3C2A, PLAT
8blood coagulationGO:0075968.4PLG, PLAT, ITGA2B, PF4, SERPINC1

Molecular functions related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:0301729.8TNNI3, TNNT2

Products for genes affiliated with Intermediate Coronary Syndrome

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  • Antibodies
  • Proteins
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Sources for Intermediate Coronary Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet