MCID: INT007
MIFTS: 54

Intermediate Coronary Syndrome malady

Cardiovascular diseases category
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Summaries for Intermediate Coronary Syndrome

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33MalaCards
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MalaCards: Intermediate Coronary Syndrome, also known as myocardial preinfarction syndrome, is related to ischemia and coronary thrombosis. An important gene associated with Intermediate Coronary Syndrome is AMH (anti-Mullerian hormone), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The drugs heparin and heparin sodium and the compounds microplasmin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Intermediate Coronary Syndrome

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

intermediate coronary syndrome 8 10
myocardial preinfarction syndrome 62
anginal chest pain at rest 8
preinfarction syndrome 8
impending infarction 8
preinfarction angina 8
angina: crescendo 8
crescendo angina 45
angina, unstable 62
worsening angina 8
unstable angina 8
angina at rest 8
unstable 8
at rest 8


Related Diseases for Intermediate Coronary Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Intermediate Coronary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.9MB, PIK3C2A, PLG, PLAT, PF4, TNNT2
2coronary thrombosis30.7SERPINC1, PLAT
3coronary artery disease30.6PF4, MB, PLG, PIK3C2A, ITGA2B, PLAT
4atherosclerosis30.3MB, PLAT, PLG, SERPINC1, PF4, ITGA2B
5congestive heart failure30.3TNNT2, TNNI3
6thrombocytosis30.2PF4, SERPINC1
7diabetes mellitus30.2PF4, PIK3C2A, ITGA2B, PLAT, PLG, SERPINC1
8antiphospholipid syndrome30.2SERPINC1, PLAT, PF4
9myocardial infarction30.0PIK3C2A, TNNT2, TNNI3, SERPINC1, AMH, PF4
10vascular disease30.0SERPINC1, PIK3C2A, TNNI3, MB, PF4, TNNT2
11acute myocardial infarction30.0SERPINC1, MB, PLG, PLAT, ITGA2B, PF4
12respiratory failure29.9PIK3C2A, SERPINC1
13dilated cardiomyopathy29.9MB, TNNI3, PIK3C2A, TNNT2
14myopathy29.9MB, PIK3C2A, TNNI3, TNNT2
15endotheliitis10.6
16artery disease10.5
17coronary stenosis10.4
18prinzmetal's variant angina10.4
19blindness10.4
20cor pulmonale10.4
21myocardial stunning10.4
22pneumonia10.4
23spontaneous coronary artery dissection10.4
24subendocardial myocardial infarction10.3
25subclavian steal syndrome10.3
26hypertension10.3
27essential thrombocythemia10.3
28cerebritis10.2
29essential hypertension10.2
30schizophrenia10.2
31peripheral vascular disease10.1
32renovascular hypertension10.1
33rheumatic fever10.1
34bernard-soulier syndrome10.1
35pituitary apoplexy10.1
36bronchiectasis10.1
37systolic heart failure10.1
38carotid stenosis10.1
39hodgkin's lymphoma10.1
40carcinoid syndrome10.1
41cytomegalovirus infection10.1
42hypoxia10.1
43coronary arterial fistulas10.1
44cystic fibrosis10.1
45major depressive disorder10.1
46paranoid schizophrenia10.1
47arteriosclerosis obliterans10.1
48chronic fatigue syndrome10.1
49intermittent claudication10.1
50arteriosclerosis10.1

Graphical network of the top 20 diseases related to Intermediate Coronary Syndrome:



Diseases related to intermediate coronary syndrome

Symptoms for Intermediate Coronary Syndrome

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Drugs & Therapeutics for Intermediate Coronary Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Intermediate Coronary Syndrome

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Anatomical Context for Intermediate Coronary Syndrome

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33MalaCards
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MalaCards organs/tissues related to Intermediate Coronary Syndrome:

33
Lung

Animal Models for Intermediate Coronary Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Intermediate Coronary Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5PLG, PLAT, ITGA2B, AMH, SERPINC1
2MP:00053857.7TNNT2, TNNI3, SERPINC1, ITGA2B, PLAT, PLG
3MP:00053977.1PIK3C2A, SERPINC1, PF4, ITGA2B, PLAT, PLG
4MP:00053766.7MB, PIK3C2A, TNNT2, SERPINC1, AMH, PF4
5MP:00107686.4PIK3C2A, TNNT2, TNNI3, SERPINC1, PLAT, PLG

Publications for Intermediate Coronary Syndrome

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Sources:
52PubMed
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Articles related to Intermediate Coronary Syndrome:

(show all 22)
idTitleAuthorsYear
1
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention. (11076127)
2000
2
A prospective study of an algorithm using cardiac troponin I and myoglobin as adjuncts in the diagnosis of acute myocardial infarction and intermediate coronary syndromes in a veteran's hospital. (11129678)
2000
3
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. (2136815)
1990
4
Atenolol, heparin and the intermediate coronary syndrome. (6113419)
1981
5
Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. (6112564)
1981
6
The intermediate coronary syndrome. (6971456)
1981
7
Pathophysiologic significance of S-T and T wave abnormalities in patients with the intermediate coronary syndrome. (299974)
1977
8
Long-term follow-up in patients receiving emergency revascularization for intermediate coronary syndrome. (4600203)
1974
9
SURGICAL MANAGEMENT OF THE INTERMEDIATE CORONARY SYNDROME. (15215960)
1974
10
Editorial: Intermediate coronary syndrome. (4148257)
1973
11
Bradycardia in intermediate coronary syndrome. (4723578)
1973
12
The natural history of intermediate coronary syndrome. (4721961)
1973
13
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects. (4144755)
1973
14
Letter: Intermediate coronary syndrome. (4752330)
1973
15
Early diagnosis of acute myocardial infarction with special reference to the diagnosis of the intermediate coronary syndrome. A clinical study. (4586014)
1972
16
Recognition and management of the intermediate coronary syndrome. (6021604)
1967
17
Diagnosis and management of the intermediate coronary syndrome. A clinical study of 400 cases of the syndrome. (5932254)
1966
18
THE INTERMEDIATE CORONARY SYNDROME. (14061336)
1963
19
Intermediate coronary syndrome. (13779654)
1961
20
Electrocardiographic changes in the intermediate coronary syndrome. II. Location of lesions. (13286446)
1956
21
The intermediate coronary syndrome. (13226558)
1955
22
I. Electrocardiographic changes in the intermediate coronary syndrome. (13211952)
1954

Variations for Intermediate Coronary Syndrome

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Expression for genes affiliated with Intermediate Coronary Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermediate Coronary Syndrome

Search GEO for disease gene expression data for Intermediate Coronary Syndrome.

Pathways for genes affiliated with Intermediate Coronary Syndrome

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 54R&D Systems, 30KEGG, 53QIAGEN
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Compounds for genes affiliated with Intermediate Coronary Syndrome

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1microplasmin459.9PLAT, PLG
2integrilin459.9PLAT, SERPINC1
3reviparin459.9PLAT, SERPINC1
4alpha-hydroxybutyrate459.9PIK3C2A, MB
5efegatran459.9SERPINC1, PLAT
6spectrozyme459.8SERPINC1, PLAT
7eaca459.7SERPINC1, PLAT
8polybrene459.7SERPINC1, PF4
9p-amino benzamidine459.6PLAT, SERPINC1
10danaparoid459.6PF4, SERPINC1
11ancrod459.6SERPINC1, PLAT
12tranexamic acid45 1110.5PLG, PLAT, SERPINC1
13epsilon aminocaproic acid459.5PLAT, SERPINC1, PLG
14isopropanol459.5PF4, MB
15fluvastatin45 51 29 1112.4MB, PIK3C2A, PLAT
16fibrinopeptide a459.3SERPINC1, PF4, PLAT
17fondaparinux459.3PF4, SERPINC1, PLAT
18protamine sulfate459.3SERPINC1, PF4, PLAT
19ticlopidine45 1110.3SERPINC1, PLAT, PF4
20iloprost61 29 45 1112.3SERPINC1, PLAT, PF4
21protamine459.3SERPINC1, PLAT, PF4
22dermatan sulfate459.2PF4, SERPINC1, PLAT
23tamoxifen45 51 29 1112.2SERPINC1, AMH, PLAT, PLG
24polyethylene glycol459.2PF4, MB, SERPINC1
25thromboxane45 2410.2PF4, PIK3C2A, PLAT
26pge1459.1PLAT, PF4, PIK3C2A
27thromboxane a245 2410.1PLAT, PF4, PIK3C2A
28tirofiban45 1110.0ITGA2B, SERPINC1, PF4, PLAT
29abciximab45 1110.0PLAT, ITGA2B, SERPINC1, PF4
30homocysteine45 2410.0PLAT, SERPINC1, PIK3C2A
31ascorbic acid45 249.9MB, PIK3C2A, PLAT, SERPINC1
32kininogen458.9PLG, SERPINC1, PF4, PLAT
33ptca458.9TNNT2, PLAT, PF4, PIK3C2A
34citrate458.9PIK3C2A, SERPINC1, PF4, MB
35nicotine45 29 51 1111.9SERPINC1, PLAT, MB, PF4
36hirudin458.8PIK3C2A, SERPINC1, PF4, PLAT
37warfarin45 51 24 1111.8PIK3C2A, SERPINC1, PF4, PLAT
38prostacyclin458.8PIK3C2A, SERPINC1, PLAT, PF4
39sodium nitroprusside458.7PIK3C2A, PLAT, MB
40estradiol45 24 1110.7AMH, PIK3C2A, PLAT, PF4
41lactate458.7PIK3C2A, TNNT2, PF4, MB, TNNI3
42lysine458.5PF4, ITGA2B, PLAT, PLG
43aprotinin45 119.5PLAT, PLG, SERPINC1, MB, PF4
44alanine458.4MB, PIK3C2A, SERPINC1, PF4, TNNT2
45vegf458.4SERPINC1, MB, PIK3C2A, PLG, PF4
46adp45 29 2410.3SERPINC1, ITGA2B, PLAT, PF4, PIK3C2A
47cysteine458.2MB, PLG, ITGA2B, PLAT, PF4
48fibrinogen458.1PIK3C2A, PLG, PLAT, ITGA2B, PF4, SERPINC1
49creatinine457.7PLAT, PF4, MB, TNNI3, TNNT2, SERPINC1
50heparin45 29 24 1110.7PIK3C2A, PLG, MB, PLAT, PF4, SERPINC1

GO Terms for genes affiliated with Intermediate Coronary Syndrome

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16Gene Ontology
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Cellular components related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.9TNNI3, TNNT2
2sarcomereGO:0300179.5TNNI3, TNNT2
3platelet alpha granule lumenGO:0310939.5PLG, PF4
4blood microparticleGO:0725629.3SERPINC1, ITGA2B, PLG
5extracellular spaceGO:0056158.3PLG, PLAT, PF4, AMH, SERPINC1
6extracellular regionGO:0055768.1SERPINC1, AMH, PF4, PLAT, PLG

Biological processes related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:0327809.9TNNT2, TNNI3
2muscle filament slidingGO:0300499.8TNNI3, TNNT2
3ventricular cardiac muscle tissue morphogenesisGO:0550109.7TNNT2, TNNI3
4fibrinolysisGO:0427309.6PLAT, PLG
5platelet degranulationGO:0025769.3PF4, ITGA2B, PLG
6platelet activationGO:0301689.2PLG, ITGA2B, PF4
7platelet-derived growth factor receptor signaling pathwayGO:0480089.1PIK3C2A, PLAT
8blood coagulationGO:0075968.4PLG, PLAT, ITGA2B, PF4, SERPINC1

Molecular functions related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:0301729.8TNNI3, TNNT2

Products for genes affiliated with Intermediate Coronary Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermediate Coronary Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet