MCID: INT007
MIFTS: 54

Intermediate Coronary Syndrome malady

Cardiovascular diseases category

Summaries for Intermediate Coronary Syndrome

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34MalaCards
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MalaCards: Intermediate Coronary Syndrome, also known as myocardial preinfarction syndrome, is related to ischemia and coronary thrombosis. An important gene associated with Intermediate Coronary Syndrome is AMH (anti-Mullerian hormone), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The drugs heparin and heparin sodium and the compounds microplasmin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Intermediate Coronary Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

intermediate coronary syndrome 9 11
myocardial preinfarction syndrome 63
anginal chest pain at rest 9
preinfarction syndrome 9
impending infarction 9
preinfarction angina 9
angina: crescendo 9
crescendo angina 46
angina, unstable 63
worsening angina 9
unstable angina 9
angina at rest 9
unstable 9
at rest 9


Related Diseases for Intermediate Coronary Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Intermediate Coronary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.9MB, PIK3C2A, PLG, PLAT, PF4, TNNT2
2coronary thrombosis30.7SERPINC1, PLAT
3coronary artery disease30.6PF4, MB, PLG, PIK3C2A, ITGA2B, PLAT
4atherosclerosis30.3MB, PLAT, PLG, SERPINC1, PF4, ITGA2B
5congestive heart failure30.3TNNT2, TNNI3
6thrombocytosis30.2PF4, SERPINC1
7diabetes mellitus30.2PF4, PIK3C2A, ITGA2B, PLAT, PLG, SERPINC1
8antiphospholipid syndrome30.2SERPINC1, PLAT, PF4
9myocardial infarction30.0PIK3C2A, TNNT2, TNNI3, SERPINC1, AMH, PF4
10vascular disease30.0SERPINC1, PIK3C2A, TNNI3, MB, PF4, TNNT2
11acute myocardial infarction30.0SERPINC1, MB, PLG, PLAT, ITGA2B, PF4
12respiratory failure29.9PIK3C2A, SERPINC1
13dilated cardiomyopathy29.9MB, TNNI3, PIK3C2A, TNNT2
14myopathy29.9MB, PIK3C2A, TNNI3, TNNT2
15endotheliitis10.6
16artery disease10.5
17coronary stenosis10.4
18prinzmetal's variant angina10.4
19blindness10.4
20cor pulmonale10.4
21myocardial stunning10.4
22pneumonia10.4
23spontaneous coronary artery dissection10.4
24subendocardial myocardial infarction10.3
25subclavian steal syndrome10.3
26hypertension10.3
27essential thrombocythemia10.3
28cerebritis10.2
29essential hypertension10.2
30schizophrenia10.2
31peripheral vascular disease10.1
32renovascular hypertension10.1
33rheumatic fever10.1
34bernard-soulier syndrome10.1
35pituitary apoplexy10.1
36bronchiectasis10.1
37systolic heart failure10.1
38carotid stenosis10.1
39hodgkin's lymphoma10.1
40carcinoid syndrome10.1
41cytomegalovirus infection10.1
42hypoxia10.1
43coronary arterial fistulas10.1
44cystic fibrosis10.1
45major depressive disorder10.1
46paranoid schizophrenia10.1
47arteriosclerosis obliterans10.1
48chronic fatigue syndrome10.1
49intermittent claudication10.1
50arteriosclerosis10.1

Graphical network of the top 20 diseases related to Intermediate Coronary Syndrome:



Diseases related to intermediate coronary syndrome

Symptoms for Intermediate Coronary Syndrome

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Drugs & Therapeutics for Intermediate Coronary Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Intermediate Coronary Syndrome

Drug clinical trials:

Search ClinicalTrials for Intermediate Coronary Syndrome

Search NIH Clinical Center for Intermediate Coronary Syndrome

Search CenterWatch for Intermediate Coronary Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

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Genetic Tests for Intermediate Coronary Syndrome

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Anatomical Context for Intermediate Coronary Syndrome

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34MalaCards
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MalaCards organs/tissues related to Intermediate Coronary Syndrome:

34
Lung

Animal Models for Intermediate Coronary Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Intermediate Coronary Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5PLG, PLAT, ITGA2B, AMH, SERPINC1
2MP:00053857.7TNNT2, TNNI3, SERPINC1, ITGA2B, PLAT, PLG
3MP:00053977.1PIK3C2A, SERPINC1, PF4, ITGA2B, PLAT, PLG
4MP:00053766.7MB, PIK3C2A, TNNT2, SERPINC1, AMH, PF4
5MP:00107686.4PIK3C2A, TNNT2, TNNI3, SERPINC1, PLAT, PLG

Publications for Intermediate Coronary Syndrome

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Sources:
53PubMed
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Articles related to Intermediate Coronary Syndrome:

(show all 22)
idTitleAuthorsYear
1
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention. (11076127)
2000
2
A prospective study of an algorithm using cardiac troponin I and myoglobin as adjuncts in the diagnosis of acute myocardial infarction and intermediate coronary syndromes in a veteran's hospital. (11129678)
2000
3
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. (2136815)
1990
4
Atenolol, heparin and the intermediate coronary syndrome. (6113419)
1981
5
Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. (6112564)
1981
6
The intermediate coronary syndrome. (6971456)
1981
7
Pathophysiologic significance of S-T and T wave abnormalities in patients with the intermediate coronary syndrome. (299974)
1977
8
Long-term follow-up in patients receiving emergency revascularization for intermediate coronary syndrome. (4600203)
1974
9
SURGICAL MANAGEMENT OF THE INTERMEDIATE CORONARY SYNDROME. (15215960)
1974
10
Editorial: Intermediate coronary syndrome. (4148257)
1973
11
Bradycardia in intermediate coronary syndrome. (4723578)
1973
12
The natural history of intermediate coronary syndrome. (4721961)
1973
13
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects. (4144755)
1973
14
Letter: Intermediate coronary syndrome. (4752330)
1973
15
Early diagnosis of acute myocardial infarction with special reference to the diagnosis of the intermediate coronary syndrome. A clinical study. (4586014)
1972
16
Recognition and management of the intermediate coronary syndrome. (6021604)
1967
17
Diagnosis and management of the intermediate coronary syndrome. A clinical study of 400 cases of the syndrome. (5932254)
1966
18
THE INTERMEDIATE CORONARY SYNDROME. (14061336)
1963
19
Intermediate coronary syndrome. (13779654)
1961
20
Electrocardiographic changes in the intermediate coronary syndrome. II. Location of lesions. (13286446)
1956
21
The intermediate coronary syndrome. (13226558)
1955
22
I. Electrocardiographic changes in the intermediate coronary syndrome. (13211952)
1954

Variations for Intermediate Coronary Syndrome

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Expression for genes affiliated with Intermediate Coronary Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermediate Coronary Syndrome

Search GEO for disease gene expression data for Intermediate Coronary Syndrome.

Pathways for genes affiliated with Intermediate Coronary Syndrome

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 55R&D Systems, 31KEGG, 54QIAGEN
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Compounds for genes affiliated with Intermediate Coronary Syndrome

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1microplasmin469.9PLAT, PLG
2integrilin469.9PLAT, SERPINC1
3reviparin469.9PLAT, SERPINC1
4alpha-hydroxybutyrate469.9PIK3C2A, MB
5efegatran469.9SERPINC1, PLAT
6spectrozyme469.8SERPINC1, PLAT
7eaca469.7SERPINC1, PLAT
8polybrene469.7SERPINC1, PF4
9p-amino benzamidine469.6PLAT, SERPINC1
10danaparoid469.6PF4, SERPINC1
11ancrod469.6SERPINC1, PLAT
12tranexamic acid46 1210.5PLG, PLAT, SERPINC1
13epsilon aminocaproic acid469.5PLAT, SERPINC1, PLG
14isopropanol469.5PF4, MB
15fluvastatin46 52 30 1212.4MB, PIK3C2A, PLAT
16fibrinopeptide a469.3SERPINC1, PF4, PLAT
17fondaparinux469.3PF4, SERPINC1, PLAT
18protamine sulfate469.3SERPINC1, PF4, PLAT
19ticlopidine46 1210.3SERPINC1, PLAT, PF4
20iloprost62 30 46 1212.3SERPINC1, PLAT, PF4
21protamine469.3SERPINC1, PLAT, PF4
22dermatan sulfate469.2PF4, SERPINC1, PLAT
23tamoxifen46 52 30 1212.2SERPINC1, AMH, PLAT, PLG
24polyethylene glycol469.2PF4, MB, SERPINC1
25thromboxane46 2510.2PF4, PIK3C2A, PLAT
26pge1469.1PLAT, PF4, PIK3C2A
27thromboxane a246 2510.1PLAT, PF4, PIK3C2A
28tirofiban46 1210.0ITGA2B, SERPINC1, PF4, PLAT
29abciximab46 1210.0PLAT, ITGA2B, SERPINC1, PF4
30homocysteine46 2510.0PLAT, SERPINC1, PIK3C2A
31ascorbic acid46 259.9MB, PIK3C2A, PLAT, SERPINC1
32kininogen468.9PLG, SERPINC1, PF4, PLAT
33ptca468.9TNNT2, PLAT, PF4, PIK3C2A
34citrate468.9PIK3C2A, SERPINC1, PF4, MB
35nicotine46 30 52 1211.9SERPINC1, PLAT, MB, PF4
36hirudin468.8PIK3C2A, SERPINC1, PF4, PLAT
37warfarin46 52 25 1211.8PIK3C2A, SERPINC1, PF4, PLAT
38prostacyclin468.8PIK3C2A, SERPINC1, PLAT, PF4
39sodium nitroprusside468.7PIK3C2A, PLAT, MB
40estradiol46 25 1210.7AMH, PIK3C2A, PLAT, PF4
41lactate468.7PIK3C2A, TNNT2, PF4, MB, TNNI3
42lysine468.5PF4, ITGA2B, PLAT, PLG
43aprotinin46 129.5PLAT, PLG, SERPINC1, MB, PF4
44alanine468.4MB, PIK3C2A, SERPINC1, PF4, TNNT2
45vegf468.4SERPINC1, MB, PIK3C2A, PLG, PF4
46adp46 30 2510.3SERPINC1, ITGA2B, PLAT, PF4, PIK3C2A
47cysteine468.2MB, PLG, ITGA2B, PLAT, PF4
48fibrinogen468.1PIK3C2A, PLG, PLAT, ITGA2B, PF4, SERPINC1
49creatinine467.7PLAT, PF4, MB, TNNI3, TNNT2, SERPINC1
50heparin46 30 25 1210.7PIK3C2A, PLG, MB, PLAT, PF4, SERPINC1

GO Terms for genes affiliated with Intermediate Coronary Syndrome

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Sources:
17Gene Ontology
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Cellular components related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.9TNNI3, TNNT2
2sarcomereGO:0300179.5TNNI3, TNNT2
3platelet alpha granule lumenGO:0310939.5PLG, PF4
4blood microparticleGO:0725629.3SERPINC1, ITGA2B, PLG
5extracellular spaceGO:0056158.3PLG, PLAT, PF4, AMH, SERPINC1
6extracellular regionGO:0055768.1SERPINC1, AMH, PF4, PLAT, PLG

Biological processes related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:0327809.9TNNT2, TNNI3
2muscle filament slidingGO:0300499.8TNNI3, TNNT2
3ventricular cardiac muscle tissue morphogenesisGO:0550109.7TNNT2, TNNI3
4fibrinolysisGO:0427309.6PLAT, PLG
5platelet degranulationGO:0025769.3PF4, ITGA2B, PLG
6platelet activationGO:0301689.2PLG, ITGA2B, PF4
7platelet-derived growth factor receptor signaling pathwayGO:0480089.1PIK3C2A, PLAT
8blood coagulationGO:0075968.4PLG, PLAT, ITGA2B, PF4, SERPINC1

Molecular functions related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:0301729.8TNNI3, TNNT2

Products for genes affiliated with Intermediate Coronary Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermediate Coronary Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet