MCID: INT007
MIFTS: 50

Intermediate Coronary Syndrome malady

Cardiovascular category

Summaries for Intermediate Coronary Syndrome

Sources:
33MalaCards
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MalaCards: Intermediate Coronary Syndrome, also known as myocardial preinfarction syndrome, is related to coronary thrombosis and coronary artery disease,. An important gene associated with Intermediate Coronary Syndrome is AMH (anti-Mullerian hormone), and among its related pathways are Dissolution of Fibrin Clot and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs heparin and heparin sodium and the compounds integrilin and reviparin have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and cardiovascular system.

Aliases & Classifications for Intermediate Coronary Syndrome

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

intermediate coronary syndrome 8 10
myocardial preinfarction syndrome 61
anginal chest pain at rest 8
preinfarction syndrome 8
impending infarction 8
preinfarction angina 8
angina: crescendo 8
worsening angina 8
angina, unstable 61
crescendo angina 45
unstable angina 8
angina at rest 8
unstable 8
at rest 8


Related Diseases for Intermediate Coronary Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intermediate Coronary Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 288)
idRelated DiseaseScoreTop Affiliating Genes
1coronary thrombosis30.7PLAT, SERPINC1
2coronary artery disease,30.7MB, PIK3C2A, ITGA2B, PF4, PLG, PLAT
3atherosclerosis30.5MB, ITGA2B, PF4, PLG, PLAT, ACE
4acute myocardial infarction30.3ITGA2B, PF4, PLG, PLAT, ACE, PAPPA
5peripheral vascular disease30.1PF4, ACE
6antiphospholipid syndrome30.1PF4, PLAT, SERPINC1
7vascular disease30.1PLAT, ACE, SERPINC1
8intermittent claudication30.1PF4
9arteriosclerosis obliterans30.1PF4
10coronary heart disease30.1SERPINC1, PAPPA, AMH, UBAP1, MB, TNNT2
11adenocarcinoma29.9PLG, PF4
12arthritis29.9PLG, MB
13stroke, ischemic29.9SERPINC1, PLAT, PF4
14thrombocytopenia29.9PIK3C2A, ITGA2B, PF4, PLG, SERPINC1
15eclampsia29.7SERPINC1
16glanzmann's thrombasthenia29.7ITGA2B, PF4
17protein c deficiency29.7PLG, SERPINC1
18neuroleptic malignant syndrome29.7MB, PIK3C2A
19cardiogenic shock29.7PIK3C2A, PLAT
20ectopic pregnancy29.7PIK3C2A, PAPPA
21slipped capital femoral epiphysis10.5
22colorectal cancer10.5
23prinzmetal's variant angina10.4
24chronic angina10.4
25myocardial stunning10.4
26spontaneous coronary artery dissection10.4
27thalassemia10.3
28subclavian steal syndrome10.3
29subendocardial myocardial infarction10.3
30essential thrombocythemia10.3
31myocardial infarction 210.3
32alpha thalassemia10.3
33osteochondritis dissecans10.3
34ataxia10.3
35pulmonary function10.2
36spondylolisthesis10.2
37plasmodium falciparum malaria10.2
38spinocerebellar ataxia10.2
39carotid stenosis10.1
40rheumatic fever10.1
41renovascular hypertension10.1
42thrombocytosis10.1
43bernard-soulier syndrome10.1
44pituitary apoplexy10.1
45bronchiectasis10.1
46coronary restenosis10.1
47systolic heart failure10.1
48diastolic heart failure10.1
49silent myocardial infarction10.1
50brain disease10.1

Graphical network of the top 20 diseases related to Intermediate Coronary Syndrome:



Diseases related to intermediate coronary syndrome

Clinical Features for Intermediate Coronary Syndrome

Drugs & Therapeutics for Intermediate Coronary Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Intermediate Coronary Syndrome

Drug clinical trials:

Search ClinicalTrials for Intermediate Coronary Syndrome

Search NIH Clinical Center for Intermediate Coronary Syndrome

Search CenterWatch for Intermediate Coronary Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

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Genetic Tests for Intermediate Coronary Syndrome

Anatomical Context for Intermediate Coronary Syndrome

Animal Models for Intermediate Coronary Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Intermediate Coronary Syndrome

Sources:
51PubMed
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Articles related to Intermediate Coronary Syndrome:

(show all 23)
idTitleAuthorsYear
1
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention. (11076127)
2000
2
A prospective study of an algorithm using cardiac troponin I and myoglobin as adjuncts in the diagnosis of acute myocardial infarction and intermediate coronary syndromes in a veteran's hospital. (11129678)
2000
3
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. (2136815)
1990
4
Atenolol, heparin and the intermediate coronary syndrome. (6113419)
1981
5
Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. (6112564)
1981
6
The intermediate coronary syndrome. (6971456)
1981
7
Pathophysiologic significance of S-T and T wave abnormalities in patients with the intermediate coronary syndrome. (299974)
1977
8
Long-term follow-up in patients receiving emergency revascularization for intermediate coronary syndrome. (4600203)
1974
9
SURGICAL MANAGEMENT OF THE INTERMEDIATE CORONARY SYNDROME. (15215960)
1974
10
Editorial: Intermediate coronary syndrome. (4148257)
1973
11
Bradycardia in intermediate coronary syndrome. (4723578)
1973
12
The natural history of intermediate coronary syndrome. (4721961)
1973
13
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects. (4144755)
1973
14
Letter: Intermediate coronary syndrome. (4752330)
1973
15
Early diagnosis of acute myocardial infarction with special reference to the diagnosis of the intermediate coronary syndrome. A clinical study. (4586014)
1972
16
Recognition and management of the intermediate coronary syndrome. (6021604)
1967
17
Diagnosis and management of the intermediate coronary syndrome. A clinical study of 400 cases of the syndrome. (5932254)
1966
18
THE INTERMEDIATE CORONARY SYNDROME. (14061336)
1963
19
"Minor" infarction. (The so-called "intermediate coronary syndrome"). (14498476)
1962
20
Intermediate coronary syndrome. (13779654)
1961
21
Electrocardiographic changes in the intermediate coronary syndrome. II. Location of lesions. (13286446)
1956
22
The intermediate coronary syndrome. (13226558)
1955
23
I. Electrocardiographic changes in the intermediate coronary syndrome. (13211952)
1954

Genetic Variations for Intermediate Coronary Syndrome

Expression for genes affiliated with Intermediate Coronary Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intermediate Coronary Syndrome

Search GEO for disease gene expression data for Intermediate Coronary Syndrome.

Pathways for genes affiliated with Intermediate Coronary Syndrome

Sources:
54Reactome, 12EMD Millipore, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Intermediate Coronary Syndrome

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 60Tocris Bioscience
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Compounds related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1integrilin4510.0PLAT, SERPINC1
2reviparin4510.0PLAT, SERPINC1
3Aminocaproic Acid1110.0PLG, PLAT
4microplasmin4510.0PLG, PLAT
5efegatran4510.0PLAT, SERPINC1
6delapril4510.0PLAT, ACE
7manidipine459.9PLAT, ACE
8spectrozyme459.8SERPINC1, PLAT
9tranexamic acid45 1110.8PLG, PLAT, SERPINC1
10epsilon aminocaproic acid459.8SERPINC1, PLAT, PLG
11polybrene459.6SERPINC1, PF4
12diltiazem45 29 1111.6SERPINC1, ACE, PLAT
13clopidogrel50 45 11 2412.6SERPINC1, ACE, PLAT
14fibrinopeptide a459.6SERPINC1, PLAT, PF4
15fondaparinux459.6PF4, PLAT, SERPINC1
16protamine sulfate459.6PF4, PLAT, SERPINC1
17ticlopidine45 1110.6PF4, PLAT, SERPINC1
18alpha-hydroxybutyrate459.6MB, PIK3C2A
19iloprost45 60 29 1112.5SERPINC1, PLAT, PF4
20protamine459.5PF4, PLAT, SERPINC1
21danaparoid459.5PF4, SERPINC1
22dermatan sulfate459.4SERPINC1, PLAT, PF4
23eaca459.4PLAT, SERPINC1
24aprotinin45 1110.3SERPINC1, PLAT, PF4, MB
25tirofiban45 1110.3ITGA2B, PF4, PLAT, SERPINC1
26abciximab45 1110.3ITGA2B, PF4, PLAT, SERPINC1
27estradiol45 11 2411.3PAPPA, PIK3C2A, AMH
28nicotine45 50 29 1112.3SERPINC1, PLAT, PF4, MB
29warfarin45 50 11 2412.2SERPINC1, PF4, PIK3C2A
30nitroglycerin45 1110.1PIK3C2A, PLAT, ACE
31fluvastatin45 50 29 1112.1MB, PIK3C2A, PLAT
32tamoxifen45 50 29 1112.1SERPINC1, PLAT, PLG, AMH
33heparan sulfate45 2410.0PF4, PLAT, PAPPA, SERPINC1
34aspirin45 50 29 2412.0PF4, PLAT, ACE, SERPINC1
35thromboxane45 249.9PLAT, PF4, PIK3C2A
36citrate458.9MB, PIK3C2A, PF4, SERPINC1
37ptca458.8TNNT2, PIK3C2A, PF4, PLAT
38kininogen458.8PF4, PLG, PLAT, ACE, SERPINC1
39hirudin458.8PIK3C2A, PF4, PLAT, SERPINC1
40lysine458.7ITGA2B, PF4, PLG, PLAT, PAPPA
41lactate458.6MB, TNNT2, TNNI3, PIK3C2A, PF4
42ascorbic acid45 249.6MB, PIK3C2A, PLAT, SERPINC1
43cysteine458.3MB, ITGA2B, PF4, PLG, PLAT, PAPPA
44prostacyclin458.3PIK3C2A, PF4, PLAT, ACE, SERPINC1
45fibrinogen458.1PIK3C2A, ITGA2B, PF4, PLG, PLAT, SERPINC1
46heparin45 29 11 2411.1MB, TNNT2, PIK3C2A, PF4, PLG, PAPPA
47vegf458.0MB, PIK3C2A, PF4, PLG, PAPPA, SERPINC1
48glucose457.6PIK3C2A, PF4, PLG, PLAT, ACE, PAPPA
49calcium45 50 11 2410.2TNNT2, TNNI3, PIK3C2A, ITGA2B, PF4, PLG
50creatinine456.9SERPINC1, MB, TNNT2, TNNI3, PIK3C2A, PF4

GO Terms for genes affiliated with Intermediate Coronary Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.9TNNI3, TNNT2
2extracellular spaceGO:0056157.5SERPINC1, AMH, PF4, PLG, PLAT, ACE
3extracellular regionGO:0055767.3AMH, PF4, PLG, PLAT, ACE, PAPPA

Biological processes related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.0TNNI3, TNNT2
2ventricular cardiac muscle tissue morphogenesisGO:0550109.9TNNI3, TNNT2
3fibrinolysisGO:0427309.6PLAT, PLG
4platelet degranulationGO:0025769.3ITGA2B, PF4, PLG
5platelet-derived growth factor receptor signaling pathwayGO:0480088.9PLAT, PIK3C2A
6blood coagulationGO:0075968.6SERPINC1, PLAT, PLG, PF4, ITGA2B

Molecular functions related to Intermediate Coronary Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin C bindingGO:0301729.6TNNI3, TNNT2
2endopeptidase activityGO:0041759.5PAPPA, ACE

Products for genes affiliated with Intermediate Coronary Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermediate Coronary Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet