MCID: INT064
MIFTS: 54

Intermediate Uveitis malady

Eye diseases, Rare diseases categories

Summaries for Intermediate Uveitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

MalaCards: Intermediate Uveitis, also known as peripheral uveoretinitis, is related to uveitis and multiple sclerosis. An important gene associated with Intermediate Uveitis is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are IL12 signaling mediated by STAT4 and Inflammatory Response Pathway. The compounds gold sodium thiomalate and mip 1alpha have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Intermediate Uveitis

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

intermediate uveitis 9
peripheral uveoretinitis 9
uveitis, intermediate 63
uveitis intermediate 46
chronic cyclitis 9


External Ids:

Disease Ontology9 DOID:12732
NCIt41 C35110
MeSH36 D015867

Related Diseases for Intermediate Uveitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Intermediate Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Uveitis Anterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis31.2TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA
2multiple sclerosis30.2CD69, TNF, CXCR3, CCR5, CCR4, IFNG
3sarcoidosis30.1IL2RA, CD69, IFNG, CCR4, TNF, CXCR3
4melanoma29.8TNF, CXCR3, CCR5, CCR4, IFNG, IL10
5pars planitis10.5
6retinitis10.4
7cataract10.3
8retinal vasculitis10.2
9cystoid macular edema10.2
10vasculitis10.2
11coccidioidomycosis10.1CD69
12farmer's lung10.1IL2RA
13blau syndrome10.1TNF
14pleurisy10.1IL2RA
15wegener's granulomatosis10.1CCR5
16contact dermatitis10.1CCR4, CXCR3
17lymphomatoid papulosis10.1CXCR3, CCR4
18skin disease10.1IL2RA
19allergic contact dermatitis10.1CCR4, CXCR3
20oral lichen planus10.1CCR5, CXCR3
21reticulosarcoma10.1CCR4, CXCR3
22rubella10.1
23posterior uveitis10.1
24choroiditis10.1
25cat-scratch disease10.1
26granuloma annulare10.1
27acne10.1
28alopecia10.1
29alopecia areata10.1
30endophthalmitis10.1
31iridocyclitis10.1
32non-hodgkin lymphoma10.1
33retinoschisis10.1
34extrinsic allergic alveolitis10.0CXCR3, IL2RA
35hypereosinophilic syndrome10.0CD69, IL2RA
36hairy cell leukemia10.0IL2RA, CXCR3
37aids dementia complex10.0CCR5, TNF
38mastocytosis10.0CD69, IL2RA
39central nervous system disease10.0CXCR3, CCR5
40pleural tuberculosis10.0IL2RA, IFNG
41peripheral t-cell lymphoma10.0IL2RA, CCR4, CXCR3
42juvenile rheumatoid arthritis10.0TNF, IL2RA
43tropical spastic paraparesis10.0IL2RA, IFNG
44mycosis fungoides10.0IL2RA, CCR4, CXCR3
45anaplastic large cell lymphoma10.0CXCR3, CCR4, IL2RA
46peritonitis10.0TNF, CD69
47periapical granuloma10.0CXCR3, CCR5, IL2RA
48pneumonia10.0IL10, TNF
49arthropathy10.0CD69, TNF
50b-cell chronic lymphocytic leukemia10.0CD69, IL2RA, CXCR3

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to intermediate uveitis

Symptoms for Intermediate Uveitis

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Drugs & Therapeutics for Intermediate Uveitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Intermediate Uveitis

Drug clinical trials:

Search ClinicalTrials for Intermediate Uveitis

Search NIH Clinical Center for Intermediate Uveitis

Search CenterWatch for Intermediate Uveitis

Genetic Tests for Intermediate Uveitis

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Anatomical Context for Intermediate Uveitis

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34MalaCards
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MalaCards organs/tissues related to Intermediate Uveitis:

34
Eye, Retina, T cells, B cells

Animal Models for Intermediate Uveitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Intermediate Uveitis:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5IL10, IFNG, CCR5, TNF
2MP:00053708.4IL10, IFNG, CCR5, TNF
3MP:00020068.4TNF, CXCR3, CCR5, IFNG, IL10
4MP:00053818.2TNF, CCR5, IFNG, IL2RA, IL10
5MP:00053858.2TNF, CXCR3, CCR5, IFNG, IL10
6MP:00053918.2TNF, CCR5, IFNG, IL10
7MP:00030128.2CD69, IL10, IFNG, CCR5, TNF
8MP:00053887.9TNF, CXCR3, CCR4, IFNG, IL10
9MP:00107687.7TNF, CXCR3, CCR5, IFNG, IL2RA, IL10
10MP:00053847.7TNF, CXCR3, CCR5, IFNG, IL10, CD69
11MP:00053976.7CD69, TNF, CXCR3, CCR5, CCR4, IFNG
12MP:00053876.6TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA

Publications for Intermediate Uveitis

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53PubMed
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Articles related to Intermediate Uveitis:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Tumor necrosis factor polymorphisms associated with tumor necrosis factor production influence the risk of idiopathic intermediate uveitis. (23378732)
2013
2
Interferon versus methotrexate in intermediate uveitis with macular edema: results of a randomized controlled clinical trial. (23786783)
2013
3
Intermediate uveitis, an ophthalmological manifestation of systemic disease. (23238072)
2013
4
Sarcoid intermediate uveitis following etanercept treatment: a case report and review of the literature. (22017171)
2012
5
Intermediate uveitis in Indian population. (21484178)
2011
6
Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant. (21273539)
2011
7
Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis. (20735295)
2011
8
Intraocular and serum cytokine profiles in patients with intermediate uveitis. (21850175)
2011
9
Young age as a risk factor for complicated course and visual outcome in intermediate uveitis in children. (20921016)
2011
10
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
11
Nonprogressive tractional inferior retinal elevation in intermediate uveitis. (20128653)
2010
12
Intermediate uveitis. (20029143)
2010
13
DNA chip-assisted diagnosis of a previously unknown etiology of intermediate uveitis- Toxoplasma gondii. (20952843)
2010
14
Clinical characteristics of intermediate uveitis in Tunisian patients. (20204460)
2010
15
Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. (19241289)
2009
16
Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis. (18321467)
2008
17
Dislocation of in-the-bag posterior chamber intraocular lens in a patient with intermediate uveitis. (17361270)
2007
18
Prospective optical coherence tomographic evaluation of the efficacy of oral and posterior subtenon corticosteroids in patients with intermediate uveitis. (16896918)
2007
19
Nonsteroidal drugs for the treatment of noninfectious posterior and intermediate uveitis. (17435428)
2007
20
Concurrent intermediate uveitis and an enhancing intracranial lesion as the initial manifestation of sarcoidosis. (16710498)
2006
21
Intermediate uveitis. (16282148)
2005
22
Quality of life and visual function in patients with intermediate uveitis. (16113373)
2005
23
Intermediate uveitis: a hospital based study. (16388249)
2004
24
Bilateral dislocation of in-the-bag posterior chamber intraocular lenses in a patient with intermediate uveitis. (14604727)
2003
25
Intermediate uveitis in childhood preceding the diagnosis of multiple sclerosis: a 13-year follow-up. (12788130)
2003
26
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
27
Search for autoantibodies against the HNK-1 carbohydrate epitope in the human eye in intermediate uveitis. (11037910)
2000
28
Ultrasound biomicroscopic imaging in intermediate uveitis. (9797661)
1998
29
The association of HLA-DR15 and intermediate uveitis. (9186099)
1997
30
Chronic Propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. (9145695)
1997
31
Long-term results of pars plana vitrectomy in the management of intermediate uveitis. (10163465)
1996
32
Association of intermediate uveitis with HLA-A28: definition of a new systemic syndrome? (7622075)
1995
33
Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases? (7711475)
1994
34
In search of intraocular antibody production to parvo B19 virus and adenovirus in intermediate uveitis. (8110689)
1993
35
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
36
Corticosteroids in the treatment of intermediate uveitis. (1730352)
1992
37
Plasma exchange and immunoglobulins in the treatment of intermediate uveitis. (1730368)
1992
38
Diseases masquerading intermediate uveitis. (1730373)
1992
39
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
40
Fluorescein angiography in intermediate uveitis. (1730346)
1992
41
Clinical picture of intermediate uveitis. (1730358)
1992
42
Intermediate uveitis and multiple sclerosis: considerations and necessary consequences for treatment. (1730341)
1992
43
Diagnostic vitrectomy in intermediate uveitis. (1730344)
1992
44
Intermediate uveitis and Lyme borreliosis. (1540569)
1992
45
HLA in intermediate uveitis. (1730372)
1992
46
Cataract extraction in intermediate uveitis. (1730359)
1992
47
Laser photocoagulation of retinal neovascularization in intermediate uveitis. (1730365)
1992
48
Do HLA antigens play a role in intermediate uveitis? (1481478)
1992
49
Opening address: intermediate uveitis. (1730339)
1992
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Variations for Intermediate Uveitis

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Expression for genes affiliated with Intermediate Uveitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermediate Uveitis

Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for genes affiliated with Intermediate Uveitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN, 31KEGG, 55R&D Systems, 56Reactome, 13EMD Millipore
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Pathways related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL2RA, IFNG
29.6IL2RA, IFNG
3
Show member pathways
IL-2 Signaling pathway39
9.6IL2RA, IFNG
49.6IL2RA, IFNG
59.5IL10, IFNG
69.4IFNG, TNF
7
Show member pathways
9.4IFNG, TNF
89.4TNF, IFNG
99.4IFNG, TNF
109.4IFNG, TNF
119.3IL10, TNF
129.3IL10, TNF
13
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.2IL2RA, IFNG, CCR5
14
Show member pathways
Type III interferon signaling39
9.1IL10, IL2RA, IFNG
15
Show member pathways
9.0TNF, CCR5, IFNG
16
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.0TNF, IFNG, IL2RA
17
Show member pathways
9.0IL2RA, IFNG, TNF
18
Show member pathways
9.0TNF, IFNG, IL2RA
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.0IL2RA, IFNG, TNF
20
Show member pathways
8.9CXCR3, CCR5, CCR4
21
Show member pathways
8.9CXCR3, CCR5, CCR4
22
Show member pathways
Peptide GPCRs39
8.9CXCR3, CCR5, CCR4
23
Show member pathways
8.9IL10, IFNG, TNF
248.9IL10, IFNG, TNF
258.9IL10, IFNG, TNF
26
Show member pathways
IL27-mediated signaling events39
8.9IL10, IFNG, TNF
27
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.9IL10, IFNG, TNF
288.9IL10, IFNG, TNF
298.9TNF, IFNG, IL10
308.9TNF, IFNG, IL10
31
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.9TNF, IFNG, IL10
328.9TNF, IFNG, IL10
33
Show member pathways
8.5IL10, IFNG, CCR5, TNF
34
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.5TNF, CCR5, IFNG, IL10
35
Show member pathways
8.5IL10, IL2RA, IFNG, TNF
36
Show member pathways
8.5TNF, IFNG, IL2RA, IL10
37
Show member pathways
8.5TNF, IFNG, IL2RA, IL10
38
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
39
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
40
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
41
Show member pathways
6.9IL10, IL2RA, IFNG, CCR4, CCR5, CXCR3

Compounds for genes affiliated with Intermediate Uveitis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate469.3IL2RA, TNF, IFNG
2mip 1alpha469.3IL10, TNF, CCR5
3larc469.2CCR4, CXCR3, CCR5
4interferon gamma469.2IFNG, IL10, TNF
55 aminosalicylic acid469.2IL10, TNF, IL2RA
6il-12469.2TNF, IFNG, IL10
7ribavirin46 52 1211.2CXCR3, IFNG, IL10, CCR5
8adalimumab46 52 1211.1IL10, IFNG, TNF
9indoleamine469.1TNF, IFNG, IL10
10imiquimod46 62 30 1212.1TNF, IL10, IFNG
11ifn-alpha469.1IL10, IL2RA, IFNG, CXCR3
12polymyxin b469.1IL10, IFNG, TNF
13gm-csf46 3010.0TNF, IFNG, IL10
14groalpha469.0TNF, CXCR3, CCR5, IL10
15tuberculin469.0IL10, IFNG, IL2RA, CD69
16allergens469.0CD69, CXCR3, IFNG, IL10
17con a469.0CD69, IL10, IL2RA, IFNG
18polyinosinic-polycytidylic acid468.9IL10, IFNG, TNF
19etanercept46 52 1210.9IL10, IFNG, CXCR3, TNF
20natalizumab46 129.9IL10, IL2RA, IFNG, TNF
21rolipram46 62 3010.9TNF, IFNG, IL10
22okt3468.9IL10, IL2RA, IFNG, TNF
232,5-oligoadenylate468.9IL10, TNF, IL2RA, IFNG
24hydrocortisone46 3 62 1211.9CXCR3, IL10, IFNG, TNF
25mycophenolate mofetil46 52 1210.8IL2RA, IL10, IFNG, TNF
26pentoxifylline46 129.8IL10, IL2RA, TNF, IFNG
27neopterin468.8TNF, IL10, IL2RA, IFNG
28thalidomide46 52 62 1211.8IL2RA, TNF, IL10, IFNG
29endotoxin468.8CXCR3, IL10, IFNG, TNF
30herbimycin a46 629.7CD69, TNF, IFNG, IL2RA
31calcitriol46 62 25 1211.6TNF, IL2RA, IL10, IFNG
32poly(i-c)468.6CD69, TNF, IFNG
33infliximab46 52 1210.6IL10, IL2RA, CXCR3, IFNG, TNF
34ivig468.5TNF, IL10, IL2RA, IFNG, CCR5
35methotrexate52 46 1210.5CD69, IL2RA, TNF, IL10
36ionomycin468.3IL10, CD69, IL2RA, IFNG, TNF
37il 10468.2TNF, IL10, IL2RA, IFNG, CCR5, CXCR3
38histamine46 30 2510.2CCR5, CXCR3, TNF, IL2RA, IL10, IFNG
39simvastatin46 52 62 30 25 1213.1CCR5, TNF, IL10, CCR4, IFNG
40prednisolone46 30 1210.1TNF, CCR4, IFNG, IL2RA, IL10
41tacrolimus46 52 1210.0IL10, CXCR3, IFNG, CD69, TNF, IL2RA
42vegf468.0TNF, IL2RA, IL10, IFNG, CXCR3
43nitric oxide46 25 1210.0IL10, CXCR3, TNF, CD69, IFNG
44thymidine46 259.0IL2RA, TNF, IFNG, IL10, CD69, CXCR3
45cyclosporin a46 30 6210.0IL10, IFNG, IL2RA, CD69, CCR5, TNF
46tarc467.8TNF, CCR5, CCR4, IFNG, IL10, CXCR3
47ccl346 308.8CCR5, IL10, IFNG, CCR4, CXCR3, TNF
48pge2467.7IFNG, IL2RA, IL10, CD69, CXCR3, TNF
49dexamethasone46 52 30 1210.7IFNG, CD69, IL2RA, CXCR3, CCR5, TNF
50rantes467.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10

GO Terms for genes affiliated with Intermediate Uveitis

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Sources:
17Gene Ontology
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Cellular components related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.8TNF, CXCR3, CCR5, CCR4, CD69
2external side of plasma membraneGO:0098976.6TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA

Biological processes related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG
2positive regulation of vitamin D biosynthetic processGO:0605579.8IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
4positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, TNF
5negative regulation of T cell proliferationGO:0421309.7IL10, IL2RA
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
7receptor biosynthetic processGO:0328009.7TNF, IL10
8negative regulation of cytokine secretion involved in immune responseGO:0027409.7TNF, IL10
9positive regulation of osteoclast differentiationGO:0456729.7TNF, IFNG
10protein import into nucleus, translocationGO:0000609.7IFNG, TNF
11negative regulation of interleukin-6 productionGO:0327159.6IL10, TNF
12positive regulation of cytokine secretionGO:0507159.6TNF, IL10
13positive regulation of nitric oxide biosynthetic processGO:0454299.5IFNG, TNF
14response to activityGO:0148239.5TNF, IL10
15calcium-mediated signalingGO:0197229.5CCR5, CXCR3, TNF
16chemokine-mediated signaling pathwayGO:0700989.5CCR4, CCR5
17cellular response to lipopolysaccharideGO:0712229.5IL10, IFNG, CCR5
18extrinsic apoptotic signaling pathwayGO:0971919.5TNF, IFNG
19response to glucocorticoidGO:0513849.3IL10, TNF
20humoral immune responseGO:0069599.3TNF, IFNG
21cell surface receptor signaling pathwayGO:0071669.3CXCR3, CCR5, IFNG, IL2RA
22positive regulation of cytosolic calcium ion concentrationGO:0072049.3CXCR3, CCR5, CCR4
23negative regulation of growth of symbiont in hostGO:0441309.3TNF, IFNG, IL10
24chemotaxisGO:0069359.3CCR4, CCR5, CXCR3
25MAPK cascadeGO:0001659.2CCR5, TNF
26response to drugGO:0424939.0IL10, IFNG, TNF
27apoptotic processGO:0069159.0TNF, CXCR3, IFNG, IL2RA
28immune responseGO:0069558.9IL2RA, CCR4, CCR5
29positive regulation of transcription from RNA polymerase II promoterGO:0459448.8IL10, IFNG, CXCR3, TNF
30inflammatory responseGO:0069548.2IL10, CCR4, CCR5, CXCR3, TNF

Molecular functions related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.0CCR4, CCR5
2cytokine activityGO:0051258.9IL10, IFNG, TNF
3chemokine receptor activityGO:0049508.8CCR4, CCR5, CXCR3

Products for genes affiliated with Intermediate Uveitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Intermediate Uveitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet