MCID: INT064
MIFTS: 54

Intermediate Uveitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Intermediate Uveitis

MalaCards integrated aliases for Intermediate Uveitis:

Name: Intermediate Uveitis 12 55 14
Uveitis, Intermediate 41 69
Peripheral Uveoretinitis 12
Uveitis Intermediate 51
Chronic Cyclitis 12
Iu 55

Characteristics:

Orphanet epidemiological data:

55
intermediate uveitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 55  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12732
MeSH 41 D015867
NCIt 46 C35110
Orphanet 55 ORPHA279914
UMLS via Orphanet 70 C0042166
ICD10 via Orphanet 33 H30.2
UMLS 69 C0042166

Summaries for Intermediate Uveitis

MalaCards based summary : Intermediate Uveitis, also known as uveitis, intermediate, is related to cervicitis and panuveitis. An important gene associated with Intermediate Uveitis is IL2RA (Interleukin 2 Receptor Subunit Alpha), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Azathioprine and Chlorambucil have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related phenotypes are cardiovascular system and cellular

Related Diseases for Intermediate Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 313)
# Related Disease Score Top Affiliating Genes
1 cervicitis 29.9 IL2 IL2RA
2 panuveitis 29.8 HLA-B IL10 TNF
3 choroiditis 29.7 IL10 TNF
4 uveitis 29.6 CXCR3 HLA-B IFNG IL10 IL2RA TNF
5 posterior uveitis 29.5 IFNG IL2 IL2RA TNF
6 rubella 29.1 HLA-B IL10 TNF
7 pneumonia 28.8 IL10 IL6 TNF
8 alopecia areata 28.7 IFNG IL2 IL2RA TNF
9 mycobacterium tuberculosis 1 28.7 CXCR3 IFNG IL10 TNF
10 aphthous stomatitis 28.4 HLA-B IL10 IL6 TNF
11 crohn's disease 28.4 IFNG IL10 IL6 TNF
12 multiple sclerosis 27.8 CXCR3 IFNG IL10 IL2 IL2RA IL6
13 brucellosis 27.5 IFNG IL10 IL2 IL2RA IL6 TNF
14 autoimmune disease 26.7 CXCR3 HLA-B IFNG IL10 IL2 IL2RA
15 congenital disorder of glycosylation, type iu 12.2
16 pars planitis 12.0
17 rickets 11.4
18 epileptic encephalopathy, early infantile, 36 11.3
19 factor xi deficiency 11.0
20 folliculitis 10.3 IFNG IL2RA
21 toxic oil syndrome 10.3 IFNG IL2RA
22 lymphoproliferative syndrome 2 10.3 CXCR3 IL2RA
23 idiopathic bronchiectasis 10.3 HLA-B IFNG
24 histoplasmosis 10.3 HLA-B IFNG
25 hypersplenism 10.3 IFNG IL2RA
26 variola major 10.3 IFNG IL2
27 berylliosis 10.3 IFNG IL2
28 nonspecific interstitial pneumonia 10.3 CXCR3 IFNG
29 sporotrichosis 10.3 IFNG IL10
30 baylisascariasis 10.2 IFNG IL10
31 atopic keratoconjunctivitis 10.2 IFNG IL2
32 pericardial tuberculosis 10.2 IFNG IL10
33 tuberculoid leprosy 10.2 IFNG IL10
34 buruli ulcer 10.2 IFNG IL10
35 chronic eosinophilic pneumonia 10.2 CXCR3 IL6
36 retinitis 10.2
37 b-cell growth factor 10.2 IFNG IL6
38 human herpesvirus 8 10.2 HLA-B IL6
39 taeniasis 10.2 IL10 TGFBR3
40 fascioliasis 10.2 IFNG IL10
41 ascaris lumbricoides infection 10.2 IFNG IL6
42 vulvovaginal candidiasis 10.2 IFNG IL2
43 peanut allergy 10.1 IFNG IL10
44 retinitis pigmentosa 44 10.1 IL10 IL2
45 relapsing polychondritis 10.1 IFNG IL6
46 eye lymphoma 10.1 IL10 IL6
47 acute transverse myelitis 10.1 IL10 IL6
48 ileocolitis 10.1 IL2RA TNF
49 extramedullary plasmacytoma 10.1 IL2 IL6
50 pure red-cell aplasia 10.1 HLA-B IL2 IL2RA

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to Intermediate Uveitis

Symptoms & Phenotypes for Intermediate Uveitis

MGI Mouse Phenotypes related to Intermediate Uveitis:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.05 CXCR3 IL2 IFNG IL10 TGFBR3 TNF
2 cellular MP:0005384 10.04 CXCR3 IL2 IFNG IL10 IL6 TGFBR3
3 hematopoietic system MP:0005397 10.03 CXCR3 IL2 IFNG IL2RA IL10 IL6
4 immune system MP:0005387 10.01 CXCR3 IL2 IFNG IL2RA IL10 IL6
5 digestive/alimentary MP:0005381 9.95 IL2 IFNG IL2RA IL10 IL6 TNF
6 endocrine/exocrine gland MP:0005379 9.93 IL2 IFNG IL2RA IL10 TNF IL6
7 mortality/aging MP:0010768 9.92 CXCR3 IL2 IFNG IL2RA IL10 TGFBR3
8 liver/biliary system MP:0005370 9.85 IL2 IFNG IL10 IL6 TGFBR3 TNF
9 neoplasm MP:0002006 9.73 IL2 IFNG IL10 IL6 CXCR3 TNF
10 reproductive system MP:0005389 9.63 IL2 IFNG IL10 TGFBR3 TNF IL6
11 respiratory system MP:0005388 9.5 IL2 IFNG IL2RA IL10 IL6 CXCR3
12 vision/eye MP:0005391 9.1 IL2 IFNG IL2RA IL10 TNF IL6

Drugs & Therapeutics for Intermediate Uveitis

Drugs for Intermediate Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4 446-86-6 2265
2
Chlorambucil Approved Phase 4 305-03-3 2708
3
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
4
Daclizumab Approved, Investigational Phase 4 152923-56-3
5
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 3 67-73-2 6215
6
Infliximab Approved Phase 4,Phase 1,Phase 2 170277-31-3
7
Methotrexate Approved Phase 4,Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941
8
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
9
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
10
Prednisone Approved, Vet_approved Phase 4,Phase 3 53-03-2 5865
11
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
15 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
16 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Alkylating Agents Phase 4
18 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Antimetabolites Phase 4,Phase 3,Phase 1,Phase 2
20 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 1,Phase 2
21 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Antitubercular Agents Phase 4,Phase 3
23 Cyclosporins Phase 4
24 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
25 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
26 Hormones Phase 4,Phase 3,Phase 2,Phase 1
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
28 Adrenocorticotropic Hormone Phase 4,Phase 2
29 beta-endorphin Phase 4,Phase 2
30 Melanocyte-Stimulating Hormones Phase 4,Phase 2
31 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
32 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
33 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
34 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1
35 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
37 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
39
protease inhibitors Phase 4,Phase 2,Phase 3
40
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
41
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
42
Adalimumab Approved Phase 3 331731-18-1 16219006
43
Difluprednate Approved Phase 3 23674-86-4 443936
44
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
45
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 59-30-3 6037
46
leucovorin Approved, Nutraceutical Phase 3,Phase 1,Phase 2 58-05-9 143 6006
47 Methylprednisolone acetate Phase 3
48 Methylprednisolone Hemisuccinate Phase 3
49 Neuroprotective Agents Phase 3
50 Prednisolone acetate Phase 3

Interventional clinical trials:

(show top 50) (show all 57)

# Name Status NCT ID Phase Drugs
1 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
3 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
4 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3 Myfortic;Decortin
5 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
6 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
7 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3 Dexamethasone;dexamethasone;Sham injection
8 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
9 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3 AIN457;AIN457;Placebo
10 Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery Completed NCT01124045 Phase 3 Difluprednate ophthalmic emulsion, 0.05%;Prednisolone acetate ophthalmic suspension, 1.0%
11 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3 Placebo;LX211;LX211;LX211
12 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3 Placebo;LX211;LX211;LX211
13 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Active, not recruiting NCT02748512 Phase 3 FAI insert
14 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3 Sham Injection;FAI Insert
15 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3 FAI insert;Sham injection
16 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Active, not recruiting NCT03097315 Phase 3
17 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Active, not recruiting NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
18 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3 adalimumab
19 Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01095250 Phase 3 AIN457;AIN457;AIN457;Placebo
20 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3 Placebo
21 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3 AIN457;AIN457;Placebo AIN457
22 Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X) Terminated NCT02375685 Phase 3
23 Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01103024 Phase 3
24 Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment Terminated NCT01747538 Phase 3 Placebo;Dose 1 gevokizumab;Dose 2 gevokizumab
25 Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis Terminated NCT01684345 Phase 3 Placebo;Dose 1 gevokizumab;Dose 2 gevokizumab
26 An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety Data Terminated NCT02258854 Phase 3 Dose 2 gevokizumab
27 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3 AIN457;Placebo
28 Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis Withdrawn NCT01327664 Phase 3
29 Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis Completed NCT00615693 Phase 2 AEB071
30 Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis , Completed NCT01526889 Phase 2 LFG316;Conventional Therapy
31 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
32 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis Completed NCT01582880 Phase 1, Phase 2 Riboflavin
33 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
34 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
35 Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study Completed NCT02620618 Phase 1, Phase 2 Intravitreal Infliximab
36 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
37 Leflunomide to Treat Uveitis Completed NCT00001863 Phase 2 Leflunomide
38 Intravitreal Sirolimus as Therapeutic Approach to Uveitis Recruiting NCT01280669 Phase 2 Intravitreal injection 440mcg;Intravitreal injection of sirolimus 880mcg
39 Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis (STAR Study) Recruiting NCT02911116 Phase 2 Ustekinumab
40 Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit Recruiting NCT02863809 Phase 1, Phase 2 Riboflavin;Dextran
41 Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study Active, not recruiting NCT01717170 Phase 1, Phase 2 Tocilizumab
42 ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) Not yet recruiting NCT02931175 Phase 2 ACTH gel
43 Safety and Preliminary Efficacy Study of V404 PDS in Uveitis Terminated NCT02125266 Phase 1, Phase 2 V404
44 Safety &Efficacy of CF101 to Subjects With Uveitis Withdrawn NCT01905124 Phase 2 CF101;Placebo
45 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
46 Sirolimus as Therapeutic Approach to Uveitis Unknown status NCT00908466 Phase 1 Sirolimus (rapamycin);Sirolimus (rapamycin)
47 The Treatment of Uveitic Cystoid Macular Edema With Topical Interferon Gamma Completed NCT00943982 Phase 1 Interferon Gamma 1-b
48 Quality of Life in Patients With Intermediate Uveitis Completed NCT01314469
49 Retisert and Cataract Surgery in Patients With Severe Uveitis Completed NCT00570830
50 Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema Completed NCT01170481

Search NIH Clinical Center for Intermediate Uveitis

Cochrane evidence based reviews: uveitis, intermediate

Genetic Tests for Intermediate Uveitis

Anatomical Context for Intermediate Uveitis

MalaCards organs/tissues related to Intermediate Uveitis:

38
Eye, Endothelial, Testes, T Cells, B Cells

Publications for Intermediate Uveitis

Articles related to Intermediate Uveitis:

(show top 50) (show all 171)
# Title Authors Year
1
Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up. ( 29370567 )
2018
2
Efficacy of Natalizumab in Intermediate Uveitis Related to Multiple Sclerosis: A Case Report. ( 29452449 )
2018
3
Long-term results of pars plana vitrectomy as an anti-inflammatory therapy of pediatric intermediate uveitis resistant to standard medical treatment. ( 28862736 )
2017
4
Amblyopia due to intermediate uveitis as the presenting symptom of Crohn's disease in a 6-year-old boy. ( 29102673 )
2017
5
Effect of Adalimumab on Visual Functioning in Patients With Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis in the VISUAL-1 and VISUAL-2 Trials. ( 28426849 )
2017
6
Patterns of Intermediate Uveitis in Children Presenting at a Tertiary Eye Care Center in South India. ( 28936054 )
2017
7
PERIPHERAL RETINOSCHISIS IN INTERMEDIATE UVEITIS. ( 28590967 )
2017
8
Enteric-coated mycophenolate sodium in the treatment of non-infectious intermediate uveitis: results of a prospective, controlled, randomised, open-label, early terminated multicentre trial. ( 28903965 )
2017
9
Disease Remission in Children and Adolescents with Intermediate Uveitis: A Survival Analysis. ( 29241207 )
2017
10
Cystoid Macular Edema in Retinitis Pigmentosa with Intermediate Uveitis Responded Well to Oral and Posterior Subtenon Steroid. ( 28353369 )
2017
11
Association between intermediate uveitis and toxocariasis in the Korean population. ( 28151857 )
2017
12
A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults. ( 29183563 )
2017
13
Re: Niederer etA al.: Predictors of long-term visual outcome in intermediate uveitis (Ophthalmology. 2017;124:393-398). ( 28645347 )
2017
14
Preoperative Inflammatory Control and Surgical Outcome of Vitrectomy in Intermediate Uveitis. ( 28465834 )
2017
15
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. ( 28570435 )
2017
16
Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center. ( 28449695 )
2017
17
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: two-year results (Ophthalmology. 2016;123:1940-1948). ( 28335961 )
2017
18
Ultra-Widefield Fluorescein Angiography in Intermediate Uveitis. ( 29040047 )
2017
19
Listeria Monocytogenes Endophthalmitis after Intermediate Uveitis and ppV for Retinal Detachment. ( 28329887 )
2017
20
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: 2-year results (Ophthalmology. 2016;123:1940-1948). ( 28734339 )
2017
21
Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. ( 27421623 )
2016
22
Bilateral intermediate uveitis with appearance of frosted branch angiitis and associated with Mycoplasma pneumoniae infection: case report and review of the literature. ( 27132140 )
2016
23
Ocular Siderosis Subsequent to a Missed Pars Plana Metallic Foreign Body that Masqueraded as Refractory Intermediate Uveitis. ( 27849408 )
2016
24
Retinal Dystrophy in 6 Young Patients Who Presented with Intermediate Uveitis. ( 27157150 )
2016
25
Peripheral Vasculitis, Intermediate Uveitis and Interferon Use in Multiple Sclerosis. ( 27800257 )
2016
26
INFLIXIMAB THERAPY IN PATIENTS WITH NONINFECTIOUS INTERMEDIATE UVEITIS RESISTANT TO CONVENTIONAL IMMUNOMODULATORY THERAPY. ( 27681002 )
2016
27
Ultra-wide Field Fluorescein Angiography in Retinitis Pigmentosa with Intermediate Uveitis. ( 27413510 )
2016
28
Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis. ( 26712559 )
2016
29
A cross-sectional study of submacular thickening in intermediate uveitis and determination of treatment threshold. ( 27188332 )
2016
30
Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis. ( 27989897 )
2016
31
Influence of baseline demographic and clinical characteristics in the visual outcome of intermediate uveitis: a survival analysis. ( 27030281 )
2016
32
Use of Immunosuppressive Medications for Treatment of Pediatric Intermediate Uveitis. ( 27960602 )
2016
33
Predictors of Long-Term Visual Outcome in Intermediate Uveitis. ( 28017424 )
2016
34
Remission of Intermediate Uveitis: Incidence and Predictive Factors. ( 26772874 )
2016
35
Associations of Systemic Diseases with Intermediate Uveitis. ( 26786193 )
2016
36
Chikungunya Virus Infection Manifesting as Intermediate Uveitis. ( 28010143 )
2016
37
Efficacy of Ozurdex implant in treatment of noninfectious intermediate uveitis. ( 26655000 )
2015
38
Discrepancy in Fluorescein Angiography and Optical Coherence Tomography Findings of Macular Edema in Intermediate Uveitis. ( 26645484 )
2015
39
Intermediate uveitis: an unusual presentation of cytomegalovirus intraocular infection in an immunocompetent patient. ( 25969485 )
2015
40
Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases. ( 26640809 )
2015
41
Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis. ( 25634309 )
2015
42
Association analysis of TGFBR3 gene with BehAset's disease and idiopathic intermediate uveitis in a Caucasian population. ( 25677673 )
2015
43
Clinical characteristics of intermediate uveitis in adult Turkish patients. ( 26309876 )
2015
44
Chronic candida endophthalmitis as a cause of intermediate uveitis. ( 25870216 )
2015
45
Quality of Life and Risks Associated with Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, or Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment Trial and Follow-up Study. ( 26298718 )
2015
46
Associations of Independent IL2RA Gene Variants with Intermediate Uveitis. ( 26133380 )
2015
47
Treatment of cystoid macular edema secondary to chronic non-infectious intermediate uveitis with an intraocular dexamethasone implant. ( 26222112 )
2015
48
A case of multiple sclerosis with bilateral intermediate uveitis. ( 26289756 )
2015
49
Benefits of Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study. ( 26298715 )
2015
50
Intermediate uveitis associated with familial Mediterranean fever. ( 26487035 )
2015

Variations for Intermediate Uveitis

Expression for Intermediate Uveitis

Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for Intermediate Uveitis

Pathways related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
2
Show member pathways
13.57 CXCR3 IFNG IL10 IL2 IL2RA IL6
3
Show member pathways
13.45 IFNG IL10 IL2 IL2RA IL6 TGFBR3
4
Show member pathways
13.32 CXCR3 IL10 IL2 IL2RA IL6 TNF
5
Show member pathways
13.28 HLA-B IFNG IL10 IL2 IL2RA IL6
6
Show member pathways
13.22 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
7
Show member pathways
12.92 HLA-B IL2 IL2RA IL6 TNF
8 12.75 IFNG IL2 IL2RA IL6
9
Show member pathways
12.74 HLA-B IFNG IL2 IL2RA IL6 TNF
10
Show member pathways
12.7 IL2 IL2RA IL6 TNF
11
Show member pathways
12.69 HLA-B IFNG IL10 IL2 IL2RA IL6
12
Show member pathways
12.61 IFNG IL10 IL2 IL2RA TNF
13
Show member pathways
12.57 IFNG IL10 IL2 IL6 TNF
14 12.54 IFNG IL10 IL2 IL2RA TNF
15
Show member pathways
12.51 IFNG IL10 IL2 IL6 TNF
16
Show member pathways
12.49 IFNG IL10 IL2 IL2RA IL6 TNF
17
Show member pathways
12.48 HLA-B IFNG IL2 TNF
18
Show member pathways
12.41 IFNG IL10 IL2 IL6 TNF
19 12.4 HLA-B IL2 IL2RA IL6 TNF
20
Show member pathways
12.33 IFNG IL10 IL2 IL2RA IL6
21
Show member pathways
12.32 IFNG IL2 IL6 TNF
22
Show member pathways
12.25 IFNG IL6 TNF
23 12.22 HLA-B IFNG IL10
24 12.22 IFNG IL10 IL6 TNF
25
Show member pathways
12.2 IFNG IL6 TNF
26
Show member pathways
12.19 IFNG IL10 TNF
27
Show member pathways
12.12 IFNG IL6 TNF
28 12.12 IFNG IL6 TNF
29 12.11 IL10 IL6 TNF
30
Show member pathways
12.02 IFNG IL2 IL2RA
31 12.02 IFNG IL2 IL6 TNF
32
Show member pathways
12.01 HLA-B IFNG IL10 IL2 IL6 TNF
33 11.95 IL10 IL6 TNF
34
Show member pathways
11.94 IFNG IL2 IL2RA
35 11.9 IFNG IL10 IL6 TNF
36 11.88 IL2RA IL6 TNF
37
Show member pathways
11.85 IFNG IL6 TGFBR3
38
Show member pathways
11.85 IFNG IL10 IL2 IL6 TNF
39 11.84 IFNG IL6 TNF
40 11.8 IFNG IL2 IL6
41 11.8 IFNG IL10 IL2 IL2RA IL6
42 11.8 IFNG IL10 IL2 IL2RA IL6 TNF
43
Show member pathways
11.77 IFNG IL2 IL2RA TNF
44 11.75 IL10 IL6 TNF
45 11.7 IL10 IL2RA IL6 TNF
46
Show member pathways
11.67 IFNG IL2 IL6 TNF
47
Show member pathways
11.64 IFNG IL2 IL2RA TNF
48 11.64 IFNG IL10 IL2 IL6 TNF
49 11.63 IFNG TGFBR3 TNF
50 11.55 IL10 IL6 TNF

GO Terms for Intermediate Uveitis

Cellular components related to Intermediate Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 IFNG IL10 IL2 IL6 TGFBR3 TNF
2 extracellular space GO:0005615 9.63 IFNG IL10 IL2 IL6 TGFBR3 TNF
3 external side of plasma membrane GO:0009897 9.26 CXCR3 IL2RA TGFBR3 TNF
4 cell surface GO:0009986 9.02 CXCR3 HLA-B IL2RA TGFBR3 TNF

Biological processes related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.8 IFNG IL2 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.77 IL10 IL6 TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.75 IL10 IL6 TNF
4 negative regulation of inflammatory response GO:0050728 9.73 IL10 IL2 IL2RA
5 regulation of receptor activity GO:0010469 9.72 IFNG IL10 IL2 IL6 TNF
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 IFNG IL2 IL6
7 response to glucocorticoid GO:0051384 9.67 IL10 IL6 TNF
8 negative regulation of mitotic cell cycle GO:0045930 9.66 IL10 TNF
9 positive regulation of cytokine secretion GO:0050715 9.66 IL10 TNF
10 protein import into nucleus, translocation GO:0000060 9.65 IFNG TNF
11 positive regulation of activated T cell proliferation GO:0042104 9.65 IL2 IL2RA
12 negative regulation of interleukin-6 production GO:0032715 9.65 IL10 TNF
13 positive regulation of T cell proliferation GO:0042102 9.65 IL2 IL2RA IL6
14 positive regulation of protein complex assembly GO:0031334 9.64 IFNG TNF
15 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.64 IL10 TNF
16 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG TNF
17 humoral immune response GO:0006959 9.63 IFNG IL6 TNF
18 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
19 positive regulation of T cell differentiation GO:0045582 9.62 IL2 IL2RA
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL10 TNF
23 positive regulation of immunoglobulin secretion GO:0051024 9.58 IL2 IL6
24 negative regulation of lipid storage GO:0010888 9.57 IL6 TNF
25 endothelial cell apoptotic process GO:0072577 9.55 IL10 TNF
26 inflammatory response GO:0006954 9.55 CXCR3 IL10 IL2RA IL6 TNF
27 negative regulation of lymphocyte proliferation GO:0050672 9.54 IL2 IL2RA
28 negative regulation of cytokine secretion involved in immune response GO:0002740 9.52 IL10 TNF
29 receptor biosynthetic process GO:0032800 9.43 IL10 TNF
30 regulation of T cell homeostatic proliferation GO:0046013 9.4 IL2 IL2RA
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
33 immune response GO:0006955 9.23 HLA-B IFNG IL10 IL2 IL2RA IL6
34 regulation of regulatory T cell differentiation GO:0045589 9.13 IFNG IL2 IL2RA

Molecular functions related to Intermediate Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL10 IL2 IL6
2 cytokine activity GO:0005125 9.02 IFNG IL10 IL2 IL6 TNF

Sources for Intermediate Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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