MCID: INT064
MIFTS: 46

Intermediate Uveitis malady

Rare diseases category

Aliases & Classifications for Intermediate Uveitis

About this section
Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt
See all sources

Aliases & Descriptions for Intermediate Uveitis:

Name: Intermediate Uveitis 8
Peripheral Uveoretinitis 8
Uveitis, Intermediate 61
 
Uveitis Intermediate 44
Chronic Cyclitis 8


Classifications:



External Ids:

Disease Ontology8 DOID:12732
MeSH33 D015867
NCIt39 C35110

Summaries for Intermediate Uveitis

About this section
Wikipedia:64 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

MalaCards based summary: Intermediate Uveitis, also known as peripheral uveoretinitis, is related to uveitis and eosinophilia. An important gene associated with Intermediate Uveitis is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are IL12 signaling mediated by STAT4 and Inflammatory Response Pathway. The compounds gold sodium thiomalate and mip 1alpha have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotypes are muscle and liver/biliary system.

Related Diseases for Intermediate Uveitis

About this section

Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
intermediate uveitis Anterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.0TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA
2eosinophilia29.4CCR4, IFNG, IL2RA, IL10, CD69
3melanoma29.1TNF, CXCR3, CCR5, CCR4, IFNG, IL10
4tuberculosis28.8TNF, CXCR3, CCR4, IFNG, IL2RA, IL10
5pars planitis10.6
6coccidioidomycosis10.5CD69
7retinitis10.5
8farmer's lung10.4IL2RA
9blau syndrome10.4TNF
10pleurisy10.4IL2RA
11wegener granulomatosis10.4CCR5
12contact dermatitis10.3CCR4, CXCR3
13lymphomatoid papulosis10.3CXCR3, CCR4
14cataract10.3
15skin disease10.3IL2RA
16allergic contact dermatitis10.3CCR4, CXCR3
17reticulosarcoma10.3CCR4, CXCR3
18oral lichen planus10.3CCR5, CXCR3
19retinal vasculitis10.2
20choroiditis10.2
21endophthalmitis10.2
22vasculitis10.2
23extrinsic allergic alveolitis10.2CXCR3, IL2RA
24hcl-v10.2IL2RA, CXCR3
25hypereosinophilic syndrome10.2CD69, IL2RA
26mastocytosis10.2CD69, IL2RA
27aids dementia complex10.2CCR5, TNF
28central nervous system disease10.2CXCR3, CCR5
29pleural tuberculosis10.1IL2RA, IFNG
30peripheral t-cell lymphoma10.1IL2RA, CCR4, CXCR3
31juvenile rheumatoid arthritis10.1TNF, IL2RA
32mycosis fungoides10.1IL2RA, CCR4, CXCR3
33tropical spastic paraparesis10.1IL2RA, IFNG
34anaplastic large cell lymphoma10.1CXCR3, CCR4, IL2RA
35peritonitis10.1TNF, CD69
36periapical granuloma10.1CXCR3, CCR5, IL2RA
37pneumonia10.1IL10, TNF
38arthropathy10.1CD69, TNF
39retinoschisis10.1
40hodgkin lymphoma10.1
41acne10.1
42alopecia10.1
43granuloma annulare10.1
44rubella10.1
45posterior uveitis10.1
46cat-scratch disease10.1
47acute disseminated encephalomyelitis10.1
48alopecia areata10.1
49iridocyclitis10.1
50sjogren's syndrome10.1IL2RA, CXCR3

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to intermediate uveitis

Symptoms for Intermediate Uveitis

About this section

Drugs & Therapeutics for Intermediate Uveitis

About this section

Drug clinical trials:

Search ClinicalTrials for Intermediate Uveitis

Search NIH Clinical Center for Intermediate Uveitis

Genetic Tests for Intermediate Uveitis

About this section

Anatomical Context for Intermediate Uveitis

About this section

MalaCards organs/tissues related to Intermediate Uveitis:

31
Eye, Retina, T cells, B cells

Animal Models for Intermediate Uveitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Intermediate Uveitis:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5CCR5, IFNG, IL10, TNF
2MP:00053708.4IL10, CCR5, IFNG, TNF
3MP:00020068.4TNF, CXCR3, CCR5, IFNG, IL10
4MP:00053818.2TNF, CCR5, IFNG, IL2RA, IL10
5MP:00053858.2CCR5, IL10, TNF, CXCR3, IFNG
6MP:00053918.2IFNG, TNF, CCR5, IL10
7MP:00030128.2IFNG, CD69, IL10, TNF, CCR5
8MP:00053887.9TNF, CXCR3, CCR4, IFNG, IL10
9MP:00107687.7CXCR3, TNF, IL10, CCR5, IFNG, IL2RA
10MP:00053847.7CXCR3, CCR5, IFNG, IL10, CD69, TNF
11MP:00053976.7IL2RA, IFNG, CCR4, CCR5, CXCR3, TNF
12MP:00053876.6CXCR3, CCR4, IFNG, IL2RA, IL10, CCR5

Publications for Intermediate Uveitis

About this section

Articles related to Intermediate Uveitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Association analysis of TGFBR3 gene with BehAset's disease and idiopathic intermediate uveitis in a Caucasian population. (25677673)
2015
2
Unilateral snow banking in tuberculosis-related intermediate uveitis. (24507077)
2014
3
Retinal hemorrhages and intermediate uveitis in a patient with drug reaction with eosinophilia and systemic symptoms syndrome: a case report. (25372334)
2014
4
Tumor necrosis factor polymorphisms associated with tumor necrosis factor production influence the risk of idiopathic intermediate uveitis. (23378732)
2013
5
Interferon versus methotrexate in intermediate uveitis with macular edema: results of a randomized controlled clinical trial. (23786783)
2013
6
Intermediate uveitis, an ophthalmological manifestation of systemic disease. (23238072)
2013
7
Sarcoid intermediate uveitis following etanercept treatment: a case report and review of the literature. (22017171)
2012
8
Intermediate uveitis in Indian population. (21484178)
2011
9
Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant. (21273539)
2011
10
Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis. (20735295)
2011
11
Intraocular and serum cytokine profiles in patients with intermediate uveitis. (21850175)
2011
12
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
13
Nonprogressive tractional inferior retinal elevation in intermediate uveitis. (20128653)
2010
14
Intermediate uveitis. (20029143)
2010
15
Clinical characteristics of intermediate uveitis in Tunisian patients. (20204460)
2010
16
Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. (19241289)
2009
17
Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis. (18321467)
2008
18
Dislocation of in-the-bag posterior chamber intraocular lens in a patient with intermediate uveitis. (17361270)
2007
19
Prospective optical coherence tomographic evaluation of the efficacy of oral and posterior subtenon corticosteroids in patients with intermediate uveitis. (16896918)
2007
20
Nonsteroidal drugs for the treatment of noninfectious posterior and intermediate uveitis. (17435428)
2007
21
Concurrent intermediate uveitis and an enhancing intracranial lesion as the initial manifestation of sarcoidosis. (16710498)
2006
22
Intermediate uveitis. (16282148)
2005
23
Quality of life and visual function in patients with intermediate uveitis. (16113373)
2005
24
Intermediate uveitis: a hospital based study. (16388249)
2004
25
Bilateral dislocation of in-the-bag posterior chamber intraocular lenses in a patient with intermediate uveitis. (14604727)
2003
26
Intermediate uveitis in childhood preceding the diagnosis of multiple sclerosis: a 13-year follow-up. (12788130)
2003
27
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
28
Pars plana vitrectomy in patients with intermediate uveitis. (11815883)
2001
29
Search for autoantibodies against the HNK-1 carbohydrate epitope in the human eye in intermediate uveitis. (11037910)
2000
30
Ultrasound biomicroscopic imaging in intermediate uveitis. (9797661)
1998
31
The association of HLA-DR15 and intermediate uveitis. (9186099)
1997
32
Chronic Propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. (9145695)
1997
33
Long-term results of pars plana vitrectomy in the management of intermediate uveitis. (10163465)
1996
34
Association of intermediate uveitis with HLA-A28: definition of a new systemic syndrome? (7622075)
1995
35
Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases? (7711475)
1994
36
In search of intraocular antibody production to parvo B19 virus and adenovirus in intermediate uveitis. (8110689)
1993
37
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
38
Corticosteroids in the treatment of intermediate uveitis. (1730352)
1992
39
Plasma exchange and immunoglobulins in the treatment of intermediate uveitis. (1730368)
1992
40
Serological evidence of an association between Lyme borreliosis and intermediate uveitis. (1730342)
1992
41
Diseases masquerading intermediate uveitis. (1730373)
1992
42
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
43
Clinical picture of intermediate uveitis. (1730358)
1992
44
Intermediate uveitis and multiple sclerosis: considerations and necessary consequences for treatment. (1730341)
1992
45
Diagnostic vitrectomy in intermediate uveitis. (1730344)
1992
46
Intermediate uveitis and Lyme borreliosis. (1540569)
1992
47
HLA in intermediate uveitis. (1730372)
1992
48
Cataract extraction in intermediate uveitis. (1730359)
1992
49
Laser photocoagulation of retinal neovascularization in intermediate uveitis. (1730365)
1992
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Variations for Intermediate Uveitis

About this section

Expression for genes affiliated with Intermediate Uveitis

About this section
Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for genes affiliated with Intermediate Uveitis

About this section

Pathways related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IFNG, IL2RA
29.6IFNG, IL2RA
3
Show member pathways
IL-2 Signaling pathway36
9.6IL2RA, IFNG
49.6IL2RA, IFNG
59.5IFNG, IL10
69.4IFNG, TNF
7
Show member pathways
9.4TNF, IFNG
89.4IFNG, TNF
99.4TNF, IFNG
109.4IFNG, TNF
119.3IL10, TNF
129.3TNF, IL10
13
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.2CCR5, IL2RA, IFNG
14
Show member pathways
Type III interferon signaling36
9.1IFNG, IL2RA, IL10
15
Show member pathways
9.0CCR5, IFNG, TNF
16
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0IFNG, IL2RA, TNF
17
Show member pathways
9.0IFNG, TNF, IL2RA
18
Show member pathways
9.0IL2RA, IFNG, TNF
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.0IL2RA, IFNG, TNF
20
Show member pathways
8.9CCR4, CCR5, CXCR3
21
Show member pathways
8.9CXCR3, CCR5, CCR4
22
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9IFNG, IL10, TNF
238.9IL10, IFNG, TNF
248.9IFNG, TNF, IL10
258.9IL10, TNF, IFNG
268.9TNF, IL10, IFNG
27
Show member pathways
8.9IFNG, TNF, IL10
288.9TNF, IFNG, IL10
29
Show member pathways
IL27-mediated signaling events36
8.9TNF, IL10, IFNG
30
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.9TNF, IL10, IFNG
318.9IL10, TNF, IFNG
32
Show member pathways
8.5IL10, CCR5, TNF, IFNG
33
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.5TNF, CCR5, IL10, IFNG
34
Show member pathways
8.5IL10, IFNG, TNF, IL2RA
35
Show member pathways
8.5IL2RA, TNF, IFNG, IL10
36
Show member pathways
8.5TNF, IFNG, IL2RA, IL10
37
Show member pathways
7.4IL10, CCR5, IL2RA, CCR4, CXCR3, TNF
38
Show member pathways
7.4TNF, IL10, IL2RA, CCR4, CCR5, CXCR3
39
Show member pathways
7.4IL10, TNF, CXCR3, CCR5, CCR4, IL2RA
40
Show member pathways
6.9IL2RA, TNF, CXCR3, CCR5, CCR4, IFNG

Compounds for genes affiliated with Intermediate Uveitis

About this section

Compounds related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate449.3IL2RA, TNF, IFNG
2mip 1alpha449.3IL10, TNF, CCR5
3larc449.2CCR4, CXCR3, CCR5
4interferon gamma449.2IFNG, IL10, TNF
55 aminosalicylic acid449.2IL10, TNF, IL2RA
6il-12449.2TNF, IFNG, IL10
7ribavirin44 50 1111.2CXCR3, IFNG, IL10, CCR5
8adalimumab44 50 1111.1IL10, IFNG, TNF
9indoleamine449.1TNF, IFNG, IL10
10imiquimod44 60 28 1112.1TNF, IL10, IFNG
11ifn-alpha449.1IL10, IL2RA, IFNG, CXCR3
12polymyxin b449.1IL10, IFNG, TNF
13gm-csf44 2810.0TNF, IFNG, IL10
14groalpha449.0TNF, CXCR3, CCR5, IL10
15tuberculin449.0IL10, IFNG, IL2RA, CD69
16allergens449.0CD69, CXCR3, IFNG, IL10
17con a449.0CD69, IL10, IL2RA, IFNG
18polyinosinic-polycytidylic acid448.9IL10, IFNG, TNF
19etanercept44 50 1110.9IL10, IFNG, CXCR3, TNF
20natalizumab44 119.9IL10, IL2RA, IFNG, TNF
21rolipram44 60 2810.9TNF, IFNG, IL10
22okt3448.9IL10, IL2RA, IFNG, TNF
232,5-oligoadenylate448.9IL10, TNF, IL2RA, IFNG
24hydrocortisone44 1 60 1111.9CXCR3, IL10, IFNG, TNF
25mycophenolate mofetil44 50 1110.8IL2RA, IL10, IFNG, TNF
26pentoxifylline44 119.8IL10, IL2RA, TNF, IFNG
27neopterin448.8TNF, IL10, IL2RA, IFNG
28thalidomide44 50 60 1111.8IL2RA, TNF, IL10, IFNG
29endotoxin448.8CXCR3, IL10, IFNG, TNF
30herbimycin a44 609.7CD69, TNF, IFNG, IL2RA
31calcitriol44 60 24 1111.6TNF, IL2RA, IL10, IFNG
32poly(i-c)448.6CD69, TNF, IFNG
33infliximab44 50 1110.6IL10, IL2RA, CXCR3, IFNG, TNF
34ivig448.5TNF, IL10, IL2RA, IFNG, CCR5
35methotrexate50 44 1110.5CD69, IL2RA, TNF, IL10
36ionomycin448.3IL10, CD69, IL2RA, IFNG, TNF
37il 10448.2TNF, IL10, IL2RA, IFNG, CCR5, CXCR3
38histamine44 28 2410.2CCR5, CXCR3, TNF, IL2RA, IL10, IFNG
39simvastatin44 50 60 28 24 1113.1CCR5, TNF, IL10, CCR4, IFNG
40prednisolone44 28 1110.1TNF, CCR4, IFNG, IL2RA, IL10
41tacrolimus44 50 1110.0IL10, CXCR3, IFNG, CD69, TNF, IL2RA
42vegf448.0TNF, IL2RA, IL10, IFNG, CXCR3
43nitric oxide44 24 1110.0IL10, CXCR3, TNF, CD69, IFNG
44thymidine44 249.0IL2RA, TNF, IFNG, IL10, CD69, CXCR3
45cyclosporin a44 28 6010.0IL10, IFNG, IL2RA, CD69, CCR5, TNF
46tarc447.8TNF, CCR5, CCR4, IFNG, IL10, CXCR3
47ccl344 288.8CCR5, IL10, IFNG, CCR4, CXCR3, TNF
48pge2447.7IFNG, IL2RA, IL10, CD69, CXCR3, TNF
49dexamethasone44 50 28 1110.7IFNG, CD69, IL2RA, CXCR3, CCR5, TNF
50rantes447.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10

GO Terms for genes affiliated with Intermediate Uveitis

About this section

Cellular components related to Intermediate Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.8CD69, CCR4, CCR5, CXCR3, TNF
2external side of plasma membraneGO:00098976.6CD69, TNF, CXCR3, CCR5, CCR4, IFNG

Biological processes related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:00453489.8IFNG, IL10
2positive regulation of vitamin D biosynthetic processGO:00605579.8IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8IFNG, TNF
4positive regulation of chemokine biosynthetic processGO:00450809.7TNF, IFNG
5negative regulation of T cell proliferationGO:00421309.7IL2RA, IL10
6positive regulation of membrane protein ectodomain proteolysisGO:00510449.7TNF, IFNG
7receptor biosynthetic processGO:00328009.7TNF, IL10
8negative regulation of cytokine secretion involved in immune responseGO:00027409.7IL10, TNF
9positive regulation of osteoclast differentiationGO:00456729.7IFNG, TNF
10protein import into nucleus, translocationGO:00000609.7IFNG, TNF
11negative regulation of interleukin-6 productionGO:00327159.6IL10, TNF
12positive regulation of cytokine secretionGO:00507159.6IL10, TNF
13positive regulation of nitric oxide biosynthetic processGO:00454299.5TNF, IFNG
14response to activityGO:00148239.5TNF, IL10
15calcium-mediated signalingGO:00197229.5CXCR3, TNF, CCR5
16chemokine-mediated signaling pathwayGO:00700989.5CCR5, CCR4
17cellular response to lipopolysaccharideGO:00712229.5IL10, IFNG, CCR5
18extrinsic apoptotic signaling pathwayGO:00971919.5IFNG, TNF
19response to glucocorticoidGO:00513849.3TNF, IL10
20humoral immune responseGO:00069599.3TNF, IFNG
21cell surface receptor signaling pathwayGO:00071669.3CXCR3, IL2RA, CCR5, IFNG
22positive regulation of cytosolic calcium ion concentrationGO:00072049.3CCR5, CXCR3, CCR4
23negative regulation of growth of symbiont in hostGO:00441309.3IL10, IFNG, TNF
24chemotaxisGO:00069359.3CCR4, CCR5, CXCR3
25MAPK cascadeGO:00001659.2TNF, CCR5
26response to drugGO:00424939.0TNF, IFNG, IL10
27apoptotic processGO:00069159.0CXCR3, IFNG, IL2RA, TNF
28immune responseGO:00069558.9CCR4, IL2RA, CCR5
29positive regulation of transcription from RNA polymerase II promoterGO:00459448.8IL10, IFNG, TNF, CXCR3
30inflammatory responseGO:00069548.2CCR4, CXCR3, CCR5, IL10, TNF

Molecular functions related to Intermediate Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:00164939.0CCR4, CCR5
2cytokine activityGO:00051258.9IL10, IFNG, TNF
3chemokine receptor activityGO:00049508.8CCR4, CCR5, CXCR3

Sources for Intermediate Uveitis

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet