MCID: INT064
MIFTS: 52

Intermediate Uveitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Intermediate Uveitis

Aliases & Descriptions for Intermediate Uveitis:

Name: Intermediate Uveitis 12 14
Uveitis, Intermediate 42 69
Peripheral Uveoretinitis 12
Uveitis Intermediate 52
Chronic Cyclitis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:12732
MeSH 42 D015867
NCIt 47 C35110
UMLS 69 C0042166

Summaries for Intermediate Uveitis

MalaCards based summary : Intermediate Uveitis, also known as uveitis, intermediate, is related to choroiditis and tuberculosis. An important gene associated with Intermediate Uveitis is IL2RA (Interleukin 2 Receptor Subunit Alpha), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Azathioprine and Chlorambucil have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotypes are cardiovascular system and cellular

Wikipedia : 71 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

Related Diseases for Intermediate Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
id Related Disease Score Top Affiliating Genes
1 choroiditis 29.5 IL10 IL6 TNF
2 tuberculosis 28.8 IL10 IL2 IL6 TNF
3 pars planitis 11.9
4 uveitis 10.7
5 brown shrimp allergy 10.2 IL10 IL2RA
6 amyotrophic lateral sclerosis type 5 10.2 IL2RA TNF
7 tungiasis 10.2 IFNG IL10
8 pseudohypoaldosteronism, type iic 10.1 CXCR3 IL2RA
9 mirizzi syndrome 10.1 HLA-B TNF
10 latent syphilis 10.1 CXCR3 IL6
11 stocco dos santos syndrome 10.1 IFNG TNF
12 cataract, total congenital 10.1 IFNG IL6
13 ureter inverted papilloma 10.1 IL10 IL6
14 distal trisomy 14q 10.1 IFNG TNF
15 neonatal hypoxic and ischemic brain injury 10.1 IL10 IL6
16 pyridoxal 5'-phosphate-dependent epilepsy 10.1 IL10 TNF
17 anterior corneal pigmentation 10.1 HLA-B IL2RA TGFBR3
18 smooth muscle tumor 10.1 CXCR3 IL2RA IL6
19 tubular renal disease-cardiomyopathy syndrome 10.1 IL10 TNF
20 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.1 IL6 TNF
21 childhood electroclinical syndrome 10.1 IL10 IL6
22 lagophthalmos 10.1 IL10 TNF
23 asymptomatic neurosyphilis 10.1 IFNG IL10 IL2RA
24 dyslexia 5 10.1 IL6 TNF
25 aortic atherosclerosis 10.1 IL6 TNF
26 degenerative disc disease 10.1 IL6 TNF
27 cervical adenoid basal carcinoma 10.1 HLA-B IL10
28 ciliary discoordination, due to random ciliary orientation 10.1 IFNG IL10 IL2RA
29 multiple vertebral anomalies unusual facies 10.1 IL10 TNF
30 conidiobolomycosis 10.1 IL10 TNF
31 unilateral multicystic dysplastic kidney 10.1 IL6 TNF
32 aniseikonia 10.1 IFNG TNF
33 endosalpingiosis 10.1 IL10 TNF
34 t-cell prolymphocytic leukemia 10.1 CXCR3 IL2RA TNF
35 retinitis 10.1
36 drug dependence 10.1 IL6 TNF
37 urethral intrinsic sphincter deficiency 10.1 IFNG TNF
38 idiopathic hypertrophic pachymeningitis 10.1 IL10 TNF
39 immune-complex glomerulonephritis 10.1 CXCR3 IFNG IL6
40 proximal symphalangism 10.1 CXCR3 IFNG IL10
41 centronuclear myopathy 5 10.1 IFNG IL10
42 anal paget's disease 10.1 IL6 TNF
43 vestibule of mouth cancer 10.1 IL10 TNF
44 tarsal tunnel syndrome 10.1 IL10 TNF
45 paralytic poliomyelitis 10.1 IFNG IL2
46 papilledema 10.1 IL6 TNF
47 caplan's syndrome 10.1 IFNG IL2
48 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.1 IL6 TNF
49 glucose intolerance 10.0 IFNG IL2RA TNF
50 oral cavity cancer 10.0 CXCR3 IFNG TNF

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to Intermediate Uveitis

Symptoms & Phenotypes for Intermediate Uveitis

MGI Mouse Phenotypes related to Intermediate Uveitis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.05 CXCR3 IFNG IL10 IL2 IL6 TGFBR3
2 cellular MP:0005384 10.04 CXCR3 IFNG IL10 IL2 IL6 TGFBR3
3 hematopoietic system MP:0005397 10.03 CXCR3 IFNG IL10 IL2 IL2RA IL6
4 immune system MP:0005387 10.01 CXCR3 IFNG IL10 IL2 IL2RA IL6
5 digestive/alimentary MP:0005381 9.95 IFNG IL10 IL2 IL2RA IL6 TNF
6 endocrine/exocrine gland MP:0005379 9.93 IFNG IL10 IL2 IL2RA IL6 TNF
7 mortality/aging MP:0010768 9.92 IL10 IL2 IL2RA IL6 TGFBR3 TNF
8 liver/biliary system MP:0005370 9.85 IFNG IL10 IL2 IL6 TGFBR3 TNF
9 neoplasm MP:0002006 9.73 CXCR3 IFNG IL10 IL2 IL6 TNF
10 reproductive system MP:0005389 9.63 IFNG IL10 IL2 IL6 TGFBR3 TNF
11 respiratory system MP:0005388 9.5 CXCR3 IFNG IL10 IL2 IL2RA IL6
12 vision/eye MP:0005391 9.1 IFNG IL10 IL2 IL2RA IL6 TNF

Drugs & Therapeutics for Intermediate Uveitis

Drugs for Intermediate Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 132)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4 446-86-6 2265
2
Chlorambucil Approved Phase 4 305-03-3 2708
3
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
4
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
5
Daclizumab Approved, Investigational Phase 4,Phase 2,Phase 1 152923-56-3
6
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 67-73-2 6215
7
Infliximab Approved Phase 4,Phase 1,Phase 2 170277-31-3
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
9
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
10
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
11
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
12
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
14 Alkylating Agents Phase 4,Phase 3
15 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
17 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
21 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
24 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Alkylating Phase 4
26 Adrenocorticotropic Hormone Phase 4,Phase 2
27 beta-endorphin Phase 4,Phase 2
28 Melanocyte-Stimulating Hormones Phase 4,Phase 2
29 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
31 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
32 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1
33 Dexamethasone 21-phosphate Phase 4,Phase 2,Phase 3,Phase 1
34 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
35 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
36 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
37
protease inhibitors Phase 4,Phase 2,Phase 3
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
39 Gramicidin Phase 4
40 Ophthalmic Solutions Phase 4
41 Polymyxin B Phase 4
42 Polymyxins Phase 4
43
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
44
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
45
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
46
Adalimumab Approved Phase 3,Phase 2 331731-18-1 16219006
47
Difluprednate Approved Phase 3,Phase 2 23674-86-4 443936
48
Sulfamethoxazole Approved Phase 3 723-46-6 5329
49
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 109)
id Name Status NCT ID Phase
1 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
3 Corneal Specular Microscopy in Infectious and Noninfectious Uveitis Completed NCT00789984 Phase 4
4 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4
5 Frozen Versus Fresh Corneal Carriers for the Boston KPro Type I Donor Carriers Enrolling by invitation NCT01950598 Phase 4
6 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Not yet recruiting NCT03133767 Phase 4
7 Oculusgen (Ologen) Glaucoma MMC Control in Estonia Unknown status NCT00524758 Phase 3
8 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3
9 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3
10 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3
11 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3
12 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3
13 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3
14 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3
15 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3
16 Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Completed NCT01243983 Phase 3
17 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3
18 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3
19 Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implants Completed NCT00407082 Phase 2, Phase 3
20 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3
21 Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery Completed NCT01124045 Phase 3
22 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Recruiting NCT03097315 Phase 3
23 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Recruiting NCT02595398 Phase 3
24 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3
25 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3
26 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Active, not recruiting NCT02748512 Phase 3
27 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3
28 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3
29 Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01095250 Phase 3
30 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3
31 Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis Terminated NCT01684345 Phase 3
32 Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment Terminated NCT01747538 Phase 3
33 Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01103024 Phase 3
34 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3
35 Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X) Terminated NCT02375685 Phase 3
36 An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety Data Terminated NCT02258854 Phase 3
37 Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implant Terminated NCT00456482 Phase 2, Phase 3
38 Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis Withdrawn NCT01327664 Phase 3
39 Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis Completed NCT00615693 Phase 2
40 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2
41 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2
42 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2
43 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2
44 Combination Daclizumab/Denileukin Diftitox to Treat Uveitis Completed NCT00326508 Phase 2
45 Phase II Study to Analyze Sarilumab in Non-Infectious Uveitis Completed NCT01900431 Phase 2
46 Everolimus for the Treatment of Uveitis Unresponsive to Cyclosporine A Completed NCT00803816 Phase 2
47 Daclizumab to Treat Non-Infectious Sight-Threatening Uveitis Completed NCT00070759 Phase 2
48 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2
49 Lucentis for Inflammatory Macular Edema Trial Completed NCT00498355 Phase 1, Phase 2
50 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2

Search NIH Clinical Center for Intermediate Uveitis

Cochrane evidence based reviews: uveitis, intermediate

Genetic Tests for Intermediate Uveitis

Anatomical Context for Intermediate Uveitis

MalaCards organs/tissues related to Intermediate Uveitis:

39
Eye, Retina, T Cells, B Cells

Publications for Intermediate Uveitis

Articles related to Intermediate Uveitis:

(show top 50) (show all 151)
id Title Authors Year
1
Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis. ( 27989897 )
2016
2
A cross-sectional study of submacular thickening in intermediate uveitis and determination of treatment threshold. ( 27188332 )
2016
3
Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. ( 27421623 )
2016
4
Chikungunya Virus Infection Manifesting as Intermediate Uveitis. ( 28010143 )
2016
5
Ocular Siderosis Subsequent to a Missed Pars Plana Metallic Foreign Body that Masqueraded as Refractory Intermediate Uveitis. ( 27849408 )
2016
6
Use of Immunosuppressive Medications for Treatment of Pediatric Intermediate Uveitis. ( 27960602 )
2016
7
Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis. ( 26712559 )
2016
8
Influence of baseline demographic and clinical characteristics in the visual outcome of intermediate uveitis: a survival analysis. ( 27030281 )
2016
9
Ultra-wide Field Fluorescein Angiography in Retinitis Pigmentosa with Intermediate Uveitis. ( 27413510 )
2016
10
Bilateral intermediate uveitis with appearance of frosted branch angiitis and associated with Mycoplasma pneumoniae infection: case report and review of the literature. ( 27132140 )
2016
11
INFLIXIMAB THERAPY IN PATIENTS WITH NONINFECTIOUS INTERMEDIATE UVEITIS RESISTANT TO CONVENTIONAL IMMUNOMODULATORY THERAPY. ( 27681002 )
2016
12
Retinal Dystrophy in 6 Young Patients Who Presented with Intermediate Uveitis. ( 27157150 )
2016
13
Peripheral Vasculitis, Intermediate Uveitis and Interferon Use in Multiple Sclerosis. ( 27800257 )
2016
14
Associations of Systemic Diseases with Intermediate Uveitis. ( 26786193 )
2016
15
Remission of Intermediate Uveitis: Incidence and Predictive Factors. ( 26772874 )
2016
16
Predictors of Long-Term Visual Outcome in Intermediate Uveitis. ( 28017424 )
2016
17
Associations of Independent IL2RA Gene Variants with Intermediate Uveitis. ( 26133380 )
2015
18
Treatment of cystoid macular edema secondary to chronic non-infectious intermediate uveitis with an intraocular dexamethasone implant. ( 26222112 )
2015
19
Clinical characteristics of intermediate uveitis in adult Turkish patients. ( 26309876 )
2015
20
Efficacy of Ozurdex implant in treatment of noninfectious intermediate uveitis. ( 26655000 )
2015
21
Intermediate uveitis associated with familial Mediterranean fever. ( 26487035 )
2015
22
Association analysis of TGFBR3 gene with BehAset's disease and idiopathic intermediate uveitis in a Caucasian population. ( 25677673 )
2015
23
Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis. ( 25634309 )
2015
24
Anterior and Intermediate Uveitis with Retinal Vasculitis: An Unusual Manifestation of Post-Streptococcal Uveitis Syndrome. ( 26713592 )
2015
25
Quality of Life and Risks Associated with Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, or Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment Trial and Follow-up Study. ( 26298718 )
2015
26
Discrepancy in Fluorescein Angiography and Optical Coherence Tomography Findings of Macular Edema in Intermediate Uveitis. ( 26645484 )
2015
27
Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA. ( 26345421 )
2015
28
Chronic candida endophthalmitis as a cause of intermediate uveitis. ( 25870216 )
2015
29
Intermediate uveitis: an unusual presentation of cytomegalovirus intraocular infection in an immunocompetent patient. ( 25969485 )
2015
30
Benefits of Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study. ( 26298715 )
2015
31
A case of multiple sclerosis with bilateral intermediate uveitis. ( 26289756 )
2015
32
Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases. ( 26640809 )
2015
33
Intermediate uveitis and multiple sclerosis: to scan or not to scan. ( 26338960 )
2015
34
Trends in patterns of intermediate uveitis in a tertiary institution in Singapore. ( 24626440 )
2014
35
Intermediate uveitis: comparison between childhood-onset and adult-onset disease. ( 23813110 )
2014
36
Unilateral snow banking in tuberculosis-related intermediate uveitis. ( 24507077 )
2014
37
Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis. ( 25176513 )
2014
38
A case of intermediate uveitis as a precursor to acute disseminated encephalomyelitis (ADEM) in a teenager. ( 24603426 )
2014
39
Intermediate uveitis in children and young adults: differences in clinical course, associations and visual outcome. ( 24713505 )
2014
40
Retinal hemorrhages and intermediate uveitis in a patient with drug reaction with eosinophilia and systemic symptoms syndrome: a case report. ( 25372334 )
2014
41
Tumor necrosis factor polymorphisms associated with tumor necrosis factor production influence the risk of idiopathic intermediate uveitis. ( 23378732 )
2013
42
Interferon versus methotrexate in intermediate uveitis with macular edema: results of a randomized controlled clinical trial. ( 23786783 )
2013
43
Review of Intermediate Uveitis. ( 26107150 )
2013
44
Intermediate uveitis, an ophthalmological manifestation of systemic disease. ( 23238072 )
2013
45
Clinical characteristics of intermediate uveitis in Chinese patients. ( 23323585 )
2013
46
Laser photocoagulation in intermediate uveitis associated with retinoschisis. ( 22827157 )
2012
47
Sarcoid intermediate uveitis following etanercept treatment: a case report and review of the literature. ( 22017171 )
2012
48
IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways? ( 21911588 )
2011
49
Intermediate uveitis in Indian population. ( 21484178 )
2011
50
Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis. ( 20735295 )
2011

Variations for Intermediate Uveitis

Expression for Intermediate Uveitis

Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for Intermediate Uveitis

Pathways related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
2
Show member pathways
13.57 CXCR3 IFNG IL10 IL2 IL2RA IL6
3
Show member pathways
13.45 IFNG IL10 IL2 IL2RA IL6 TGFBR3
4
Show member pathways
13.32 CXCR3 IL10 IL2 IL2RA IL6 TNF
5
Show member pathways
13.28 HLA-B IFNG IL10 IL2 IL2RA IL6
6
Show member pathways
13.22 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
7
Show member pathways
12.87 IFNG IL10 IL2 IL6 TNF
8
Show member pathways
12.74 HLA-B IFNG IL2 IL2RA IL6 TNF
9
Show member pathways
12.72 HLA-B IFNG IL10 IL2 IL2RA IL6
10
Show member pathways
12.71 IL2 IL2RA IL6 TNF
11
Show member pathways
12.61 IFNG IL10 IL2 IL2RA TNF
12
Show member pathways
12.56 IFNG IL10 IL2 IL6 TNF
13 12.52 IFNG IL10 IL2 IL2RA TNF
14
Show member pathways
12.51 IFNG IL10 IL2 IL2RA IL6 TNF
15
Show member pathways
12.48 HLA-B IFNG IL2 TNF
16
Show member pathways
12.41 IFNG IL10 IL2 IL6 TNF
17 12.4 HLA-B IL2 IL2RA IL6 TNF
18
Show member pathways
12.32 IFNG IL2 IL6 TNF
19
Show member pathways
12.25 IFNG IL6 TNF
20 12.22 HLA-B IFNG IL10
21 12.22 IFNG IL10 IL6 TNF
22
Show member pathways
12.2 IFNG IL6 TNF
23
Show member pathways
12.18 IFNG IL10 TNF
24
Show member pathways
12.17 IFNG IL10 IL2 IL2RA IL6
25
Show member pathways
12.12 IFNG IL6 TNF
26 12.12 IFNG IL6 TNF
27 12.11 IL10 IL6 TNF
28
Show member pathways
12.02 IFNG IL2 IL2RA
29 12.02 IFNG IL2 IL6 TNF
30
Show member pathways
12.01 HLA-B IFNG IL10 IL2 IL6 TNF
31 11.95 IL10 IL6 TNF
32
Show member pathways
11.94 IFNG IL2 IL2RA
33 11.9 IFNG IL10 IL6 TNF
34
Show member pathways
11.89 IFNG IL6 TGFBR3
35
Show member pathways
11.88 IFNG IL10 IL2 IL6 TNF
36 11.87 IL2RA IL6 TNF
37 11.84 IFNG IL6 TNF
38 11.79 IFNG IL2 IL6
39
Show member pathways
11.77 IFNG IL2 IL2RA TNF
40 11.75 IL10 IL6 TNF
41 11.73 IL10 IL2RA IL6 TNF
42 11.7 IFNG IL10 IL2 IL2RA IL6 TNF
43 11.68 IFNG IL10 IL2 IL6 TNF
44
Show member pathways
11.67 IFNG IL2 IL6 TNF
45
Show member pathways
11.64 IFNG IL2 IL2RA TNF
46 11.63 IFNG TGFBR3 TNF
47 11.59 IFNG IL10 IL2 IL2RA IL6
48 11.56 IFNG IL2 IL6 TNF
49 11.55 IL10 IL6 TNF
50 11.54 IFNG IL2 TNF

GO Terms for Intermediate Uveitis

Cellular components related to Intermediate Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 IFNG IL10 IL2 IL6 TGFBR3 TNF
2 extracellular space GO:0005615 9.63 IFNG IL10 IL2 IL6 TGFBR3 TNF
3 cell surface GO:0009986 9.35 CXCR3 HLA-B IL2RA TGFBR3 TNF
4 external side of plasma membrane GO:0009897 9.1 CXCR3 IFNG IL2RA IL6 TGFBR3 TNF

Biological processes related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show all 44)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 IFNG IL10 IL6 TNF
2 defense response to bacterium GO:0042742 9.87 IFNG IL10 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.84 IFNG IL2 TNF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.8 IL10 IL6 TNF
5 inflammatory response GO:0006954 9.77 CXCR3 IL10 IL2RA IL6 TNF
6 negative regulation of inflammatory response GO:0050728 9.76 IL10 IL2 IL2RA
7 response to glucocorticoid GO:0051384 9.75 IL10 IL6 TNF
8 humoral immune response GO:0006959 9.71 IFNG IL6 TNF
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 IFNG IL2 IL6
10 positive regulation of cytokine secretion GO:0050715 9.69 IL10 TNF
11 protein import into nucleus, translocation GO:0000060 9.69 IFNG TNF
12 negative regulation of mitotic cell cycle GO:0045930 9.68 IL10 TNF
13 positive regulation of activated T cell proliferation GO:0042104 9.68 IL2 IL2RA
14 negative regulation of interleukin-6 production GO:0032715 9.68 IL10 TNF
15 positive regulation of protein complex assembly GO:0031334 9.67 IFNG TNF
16 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
17 positive regulation of T cell differentiation GO:0045582 9.66 IL2 IL2RA
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.66 IL10 TNF
19 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG TNF
21 cellular response to hepatocyte growth factor stimulus GO:0035729 9.64 IL10 IL6
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 IL10 TNF
23 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL6
24 positive regulation of protein import into nucleus, translocation GO:0033160 9.63 IFNG IL6
25 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IFNG TNF
26 cellular response to lipopolysaccharide GO:0071222 9.62 IFNG IL10 IL6 TNF
27 positive regulation of isotype switching to IgG isotypes GO:0048304 9.61 IFNG IL2
28 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 IFNG IL6 TNF
30 endothelial cell apoptotic process GO:0072577 9.6 IL10 TNF
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 IFNG IL10
32 negative regulation of cytokine secretion involved in immune response GO:0002740 9.57 IL10 TNF
33 negative regulation of lymphocyte proliferation GO:0050672 9.56 IL2 IL2RA
34 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.55 IL6 TNF
35 receptor biosynthetic process GO:0032800 9.51 IL10 TNF
36 regulation of T cell homeostatic proliferation GO:0046013 9.49 IL2 IL2RA
37 neutrophil apoptotic process GO:0001781 9.48 IFNG IL6
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IFNG TNF
39 defense response to protozoan GO:0042832 9.43 IFNG IL10 IL6
40 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
41 negative regulation of growth of symbiont in host GO:0044130 9.33 IFNG IL10 TNF
42 positive regulation of T cell proliferation GO:0042102 9.26 IFNG IL2 IL2RA IL6
43 immune response GO:0006955 9.23 HLA-B IFNG IL10 IL2 IL2RA IL6
44 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.05 IFNG IL10 IL2 IL6 TNF

Molecular functions related to Intermediate Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL10 IL2 IL6
2 cytokine activity GO:0005125 9.02 IFNG IL10 IL2 IL6 TNF

Sources for Intermediate Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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37 KEGG
38 LifeMap
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65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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