MCID: INT064
MIFTS: 50

Intermediate Uveitis malady

Summaries for Intermediate Uveitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

MalaCards: Intermediate Uveitis, also known as peripheral uveoretinitis, is related to uveitis and multiple sclerosis. An important gene associated with Intermediate Uveitis is PRRT2 (proline-rich transmembrane protein 2), and among its related pathways are Leishmaniasis and TGF-Beta Pathway. The compounds endotoxin and ivig have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Aliases & Classifications for Intermediate Uveitis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

intermediate uveitis 8
peripheral uveoretinitis 8
uveitis, intermediate 60
uveitis intermediate 44
chronic cyclitis 8


External Ids:

Disease Ontology8 DOID:12732
NCIt39 C35110
MeSH34 D015867

Related Diseases for Intermediate Uveitis

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17GeneCards, 18GeneDecks
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Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
intermediate uveitis Anterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis31.5IL10, IL2RA, CXCR3, CD69, TNF, IFNG
2multiple sclerosis30.5CCR4, CCR5, IFNG, TNF, CD69, CXCR3
3vasculitis30.2TNF
4sarcoidosis30.2CCR4, CCR5, IFNG, TNF, CD69, CXCR3
5alopecia areata30.0IFNG
6melanoma30.0CCR4, CCR5, IFNG, TNF, CXCR3, IL10
7pars planitis10.5
8posterior uveitis10.5
9retinitis10.3
10cataract10.3
11cystoid macular edema10.2
12retinal vasculitis10.2
13rubella10.0
14non-hodgkin lymphoma10.0
15choroiditis10.0
16cat-scratch disease10.0
17chronic endophthalmitis10.0
18posterior dislocation of lens10.0
19granuloma annulare10.0
20acne10.0
21alopecia10.0
22endophthalmitis10.0
23iridocyclitis10.0
24retinal disease10.0
25retinoschisis10.0
26nephritis10.0CXCR3
27lichen planus10.0CXCR3
28human immunodeficiency virus infectious disease10.0CD69
29bronchiolitis obliterans10.0CXCR3
30proliferative glomerulonephritis10.0CXCR3
31endometriosis10.0CD69
32coccidioidomycosis10.0CD69
33chagas disease10.0CCR5
34wegener's granulomatosis10.0CCR5
35glomerulonephritis10.0CCR5
36migraine10.0PRRT2
37acquired immunodeficiency syndrome10.0CCR5
38ovarian cancer10.0CD69
39alzheimer's disease10.0CXCR3
40guillain-barre syndrome10.0CCR5
41encephalitis10.0CCR5
42myocardial infarction10.0CCR5
43interstitial lung disease10.0TNF
44polymyositis10.0CCR5
45psoriatic arthritis10.0TNF
46periodontal disease10.0TNF
47ankylosing spondylitis10.0TNF
48coronary heart disease10.0CCR5
49crohn's disease10.0TNF
50pleurisy10.0IL2RA

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to intermediate uveitis

Clinical Features for Intermediate Uveitis

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Drugs & Therapeutics for Intermediate Uveitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intermediate Uveitis

Drug clinical trials:

Search ClinicalTrials for Intermediate Uveitis

Search NIH Clinical Center for Intermediate Uveitis

Search CenterWatch for Intermediate Uveitis

Genetic Tests for Intermediate Uveitis

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Anatomical Context for Intermediate Uveitis

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32MalaCards
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MalaCards organs/tissues related to Intermediate Uveitis:

32
Eye, Retina, T cells, B cells

Animal Models for Intermediate Uveitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intermediate Uveitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.9CD69
2MP:00053889.8CXCR3
3MP:00020068.2CCR5, IFNG, TNF, CXCR3, IL10
4MP:00053818.1IFNG, TNF, IL2RA, IL10, CCR5
5MP:00053847.2CCR5, IFNG, TNF, CD69, CXCR3, IL2RA
6MP:00053976.9CCR4, CCR5, IFNG, TNF, CD69, IL2RA
7MP:00053876.6IL10, CCR4, CCR5, IFNG, TNF, CD69

Publications for Intermediate Uveitis

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50PubMed
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Articles related to Intermediate Uveitis:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Vision-related functioning outcomes of dexamethasone intravitreal implant in noninfectious intermediate or posterior uveitis. (23761087)
2013
2
Interferon versus methotrexate in intermediate uveitis with macular edema: results of a randomized controlled clinical trial. (23786783)
2013
3
Psychometric evaluation of the National Eye Institute Visual Function Questionnaire and Visual Function Questionnaire Utility Index in patients with non-infectious intermediate and posterior uveitis. (23645458)
2013
4
Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. (21840602)
2011
5
Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant. (21273539)
2011
6
Rubella-related intermediate uveitis in pregnancy--a rare presentation. (21595530)
2011
7
Intermediate uveitis and alopecia areata: is there a relationship? Report of 3 pediatric cases. (21949137)
2011
8
IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways? (21911588)
2011
9
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
10
DNA chip-assisted diagnosis of a previously unknown etiology of intermediate uveitis- Toxoplasma gondii. (20952843)
2010
11
Clinical characteristics of intermediate uveitis in Tunisian patients. (20204460)
2010
12
Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. (19241289)
2009
13
Searching for intraocular antibody production against Parvovirus B19, Mumps virus and Measles virus in patients with intermediate and posterior uveitis. (19471008)
2009
14
An unusual optic disc neovascularization in a case of intermediate uveitis associated with multiple sclerosis. (18988181)
2008
15
Prospective optical coherence tomographic evaluation of the efficacy of oral and posterior subtenon corticosteroids in patients with intermediate uveitis. (16896918)
2007
16
Intermediate and posterior uveitis. (17264499)
2007
17
Fluorescein angiographic findings in cases with intermediate uveitis in the inactive phase. (17361250)
2007
18
Anterior and intermediate uveitis cases referred to a tertiary centre in Alberta. (18033328)
2007
19
Long-term follow-up of intermediate uveitis in children. (16564794)
2006
20
Intermediate uveitis. (16282148)
2005
21
Quality of life and visual function in patients with intermediate uveitis. (16113373)
2005
22
Clinical features and visual outcome of intermediate uveitis in children. (15670074)
2005
23
Cyclosporine vs tacrolimus therapy for posterior and intermediate uveitis. (15883282)
2005
24
Systemic CD4(+) T cell phenotype and activation status in intermediate uveitis. (14977779)
2004
25
Intermediate uveitis in childhood preceding the diagnosis of multiple sclerosis: a 13-year follow-up. (12788130)
2003
26
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
27
Effect of a drug combination treatment on ocular perfusion in recurrent idiopathic intermediate uveitis. (14704901)
2003
28
Intermediate uveitis. (12434479)
2002
29
Search for autoantibodies against the HNK-1 carbohydrate epitope in the human eye in intermediate uveitis. (11037910)
2000
30
Soluble ICAM-1 serum levels in patients with intermediate uveitis. (10381673)
1999
31
Familial intermediate uveitis: a case report of two brothers. (10707159)
1999
32
Evaluation of cataract surgery in intermediate uveitis. (10100252)
1999
33
Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. (10377437)
1999
34
Ultrasound biomicroscopic imaging in intermediate uveitis. (9797661)
1998
35
Intermediate uveitis of pars planitis type in identical twins. Report of a case. (10826543)
1998
36
The association of HLA-DR15 and intermediate uveitis. (9186099)
1997
37
Long-term results of pars plana vitrectomy in the management of intermediate uveitis. (10163465)
1996
38
Tear deficiency in Fuchs' intermediate uveitis. (8925480)
1996
39
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
40
Diseases masquerading intermediate uveitis. (1730373)
1992
41
Intermediate uveitis and multiple sclerosis: considerations and necessary consequences for treatment. (1730341)
1992
42
Diagnostic vitrectomy in intermediate uveitis. (1730344)
1992
43
Cataract extraction in intermediate uveitis. (1730359)
1992
44
Laser photocoagulation of retinal neovascularization in intermediate uveitis. (1730365)
1992
45
Epidemiology of intermediate uveitis: a prospective study in Savoy. (1730371)
1992
46
Intermediate uveitis and sarcoidosis. (1730340)
1992
47
Pathology of intermediate uveitis. (1730376)
1992
48
Cellular phenotype of vitreous cells in intermediate uveitis. (1730347)
1992
49
Nonsteroid anti-inflammatory drugs in the treatment of intermediate uveitis. (1730351)
1992
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Genetic Variations for Intermediate Uveitis

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Expression for genes affiliated with Intermediate Uveitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermediate Uveitis

Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for genes affiliated with Intermediate Uveitis

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems
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Pathways related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1CCR5
2
Hide members
10.1IL2RA
310.1IL2RA
49.6IFNG, IL2RA
59.6IL2RA, IFNG
69.5IL10, IFNG
79.4IFNG, TNF
89.3TNF, IL10
9
Hide members
9.2IL2RA, IFNG, CCR5
109.1IL10, IL2RA, IFNG
11
Hide members
9.0CCR5, IFNG, TNF
12
Hide members
9.0IL2RA, TNF, IFNG
139.0IL2RA, TNF, IFNG
14
Hide members
8.9CXCR3, CCR5, CCR4
158.9CCR4, CCR5, CXCR3
16
Hide members
8.9CXCR3, CCR5, CCR4
17
Hide members
8.9CXCR3, CCR5, CCR4
18
Hide members
8.9IFNG, TNF, IL10
19
Hide members
8.9IFNG, TNF, IL10
208.9IFNG, TNF, IL10
218.9IFNG, TNF, IL10
228.9IFNG, TNF, IL10
23
Development PDGF signaling via STATs and NF-kB
Hide members
8.9IL10, TNF, IFNG
24
Hide members
8.9IFNG, TNF, IL10
258.9IL10, TNF, IFNG
26
Hide members
8.5CCR4, CCR5, CXCR3, IL2RA
27
Hide members
8.5CCR4, CCR5, CXCR3, IL2RA
28
Hide members
8.5CCR5, IFNG, TNF, IL10
29
Hide members
8.5IL10, IL2RA, TNF, IFNG
30
Hide members
8.5IFNG, TNF, IL2RA, IL10
31
Hide members
7.4CCR4, CCR5, TNF, CXCR3, IL2RA, IL10

Compounds for genes affiliated with Intermediate Uveitis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.4CXCR3
2ivig4410.1CCR5, IFNG
3ccl11289.9CCR5, CXCR3
4ccl13289.9CXCR3, CCR5
52,5-oligoadenylate449.9IL2RA, TNF
6ccl5289.8CXCR3, CCR5
7ccl7289.8CXCR3, CCR5
8prednisolone44 28 1111.7CCR4, IL2RA
9cyclosporin a44 28 5911.5CD69, IL2RA, IFNG
10gold sodium thiomalate449.3TNF, IL2RA, IFNG
11mip 1alpha449.3IL10, CCR5, TNF
12mycophenolate mofetil44 49 1111.3IL2RA, IL10, IFNG
13larc449.3CCR5, CXCR3, CCR4
14interferon gamma449.3TNF, IFNG, IL10
155 aminosalicylic acid449.3IL10, IL2RA, TNF
16adalimumab44 49 1111.2IFNG, IL10, TNF
17il-12449.2IL10, IFNG, TNF
18imiquimod44 28 59 1112.2IFNG, TNF, IL10
19polymyxin b449.2IL10, TNF, IFNG
20ribavirin44 49 1111.2IFNG, CXCR3, IL10, CCR5
21gm-csf44 2810.2TNF, IFNG, IL10
22polyinosinic-polycytidylic acid449.1IFNG, TNF, IL10
23ifn-alpha449.1IL2RA, IL10, CXCR3, IFNG
24poly(i-c)449.1TNF, IFNG, CD69
25rantes449.1CXCR3, TNF, IFNG, IL2RA
26ccl444 2810.1CXCR3, CCR5, CCR4
27groalpha449.0CXCR3, IL10, TNF, CCR5
28allergens449.0CD69, IFNG, IL10, CXCR3
29tuberculin449.0IL10, CD69, IL2RA, IFNG
30con a449.0IFNG, CD69, IL2RA, IL10
31etanercept44 49 1110.9TNF, CXCR3, IFNG, IL10
32natalizumab44 119.9IFNG, IL10, IL2RA, TNF
33okt3448.9IFNG, TNF, IL2RA, IL10
3415-deoxy-delta-12,14-prostaglandin j2448.9IL10, TNF, IFNG
35neopterin448.8IL2RA, IL10, TNF, IFNG
36thalidomide44 49 59 1111.8TNF, IL2RA, IL10, IFNG
37herbimycin a44 599.8IL2RA, CD69, TNF, IFNG
38calcitriol44 59 11 2411.7IL2RA, TNF, IFNG, IL10
39methotrexate44 49 1110.6IL10, IL2RA, TNF, CD69
40rituximab44 49 1110.6IL10, TNF, IL2RA
41infliximab44 49 1110.6IL10, TNF, IFNG, IL2RA, CXCR3
42ionomycin448.3IL10, IFNG, CD69, IL2RA, TNF
43il 10448.2CCR5, IFNG, TNF, CXCR3, IL2RA, IL10
44histamine44 28 2410.2CCR5, IFNG, TNF, CXCR3, IL2RA, IL10
45simvastatin44 49 59 28 11 2413.1TNF, IFNG, CCR5, CCR4, IL10
46tacrolimus44 49 1110.0TNF, IFNG, IL2RA, IL10, CD69, CXCR3
47vegf448.0IL2RA, CXCR3, IFNG, TNF, IL10
48thymidine44 249.0IL10, IL2RA, IFNG, TNF, CXCR3, CD69
49tarc447.8CXCR3, TNF, IFNG, CCR5, IL10, CCR4
50ccl344 288.8TNF, IFNG, CCR4, CCR5, CXCR3, IL10

GO Terms for genes affiliated with Intermediate Uveitis

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16Gene Ontology
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Cellular components related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058877.8CXCR3, CD69, TNF, CCR5, CCR4
2external side of plasma membraneGO:0098976.6IL2RA, CCR4, CCR5, IFNG, TNF, CD69

Biological processes related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG
2positive regulation of vitamin D biosynthetic processGO:0605579.7TNF, IFNG
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IFNG
4positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IFNG
5receptor biosynthetic processGO:0328009.7IL10, TNF
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.6TNF, IFNG
7negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
8positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
9protein import into nucleus, translocationGO:0000609.5TNF, IFNG
10negative regulation of interleukin-6 productionGO:0327159.5TNF, IL10
11calcium-mediated signalingGO:0197229.5CCR5, TNF, CXCR3
12chemokine-mediated signaling pathwayGO:0700989.5CCR5, CCR4
13cellular response to lipopolysaccharideGO:0712229.4CCR5, IFNG, IL10
14extrinsic apoptotic signaling pathwayGO:0971919.4IFNG, TNF
15response to activityGO:0148239.4IL10, TNF
16positive regulation of nitric oxide biosynthetic processGO:0454299.4TNF, IFNG
17negative regulation of T cell proliferationGO:0421309.2IL10, IL2RA
18cell surface receptor signaling pathwayGO:0071669.2IL2RA, CXCR3, IFNG, CCR5
19positive regulation of cytokine secretionGO:0507159.2TNF, IL10
20negative regulation of growth of symbiont in hostGO:0441309.2IFNG, TNF, IL10
21elevation of cytosolic calcium ion concentrationGO:0072049.2CCR4, CCR5, CXCR3
22chemotaxisGO:0069359.2CXCR3, CCR5, CCR4
23apoptotic processGO:0069158.8IFNG, TNF, CXCR3, IL2RA
24inflammatory responseGO:0069548.2IL10, CXCR3, TNF, CCR5, CCR4

Molecular functions related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.0CCR5, CCR4
2cytokine activityGO:0051258.9IL10, TNF, IFNG
3chemokine receptor activityGO:0049508.8CXCR3, CCR5, CCR4

Products for genes affiliated with Intermediate Uveitis

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  • Antibodies
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Sources for Intermediate Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet