MCID: INT064
MIFTS: 50

Intermediate Uveitis malady

Summaries for Intermediate Uveitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

MalaCards: Intermediate Uveitis, also known as peripheral uveoretinitis, is related to uveitis and multiple sclerosis. An important gene associated with Intermediate Uveitis is PRRT2 (proline-rich transmembrane protein 2), and among its related pathways are Leishmaniasis and TGF-Beta Pathway. The compounds endotoxin and ivig have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Aliases & Classifications for Intermediate Uveitis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

intermediate uveitis 8
peripheral uveoretinitis 8
uveitis, intermediate 60
uveitis intermediate 44
chronic cyclitis 8


External Ids:

Disease Ontology8 DOID:12732
NCIt39 C35110
MeSH34 D015867

Related Diseases for Intermediate Uveitis

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17GeneCards, 18GeneDecks
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Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
intermediate uveitis Anterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis31.5IL10, IL2RA, CXCR3, CD69, TNF, IFNG
2multiple sclerosis30.5CCR4, CCR5, IFNG, TNF, CD69, CXCR3
3vasculitis30.2TNF
4sarcoidosis30.2CCR4, CCR5, IFNG, TNF, CD69, CXCR3
5alopecia areata30.0IFNG
6melanoma30.0CCR4, CCR5, IFNG, TNF, CXCR3, IL10
7pars planitis10.5
8posterior uveitis10.5
9retinitis10.3
10cataract10.3
11cystoid macular edema10.2
12retinal vasculitis10.2
13rubella10.0
14non-hodgkin lymphoma10.0
15choroiditis10.0
16cat-scratch disease10.0
17chronic endophthalmitis10.0
18posterior dislocation of lens10.0
19granuloma annulare10.0
20acne10.0
21alopecia10.0
22endophthalmitis10.0
23iridocyclitis10.0
24retinal disease10.0
25retinoschisis10.0
26nephritis10.0CXCR3
27lichen planus10.0CXCR3
28human immunodeficiency virus infectious disease10.0CD69
29bronchiolitis obliterans10.0CXCR3
30proliferative glomerulonephritis10.0CXCR3
31endometriosis10.0CD69
32coccidioidomycosis10.0CD69
33chagas disease10.0CCR5
34wegener's granulomatosis10.0CCR5
35glomerulonephritis10.0CCR5
36migraine10.0PRRT2
37acquired immunodeficiency syndrome10.0CCR5
38ovarian cancer10.0CD69
39alzheimer's disease10.0CXCR3
40guillain-barre syndrome10.0CCR5
41encephalitis10.0CCR5
42myocardial infarction10.0CCR5
43interstitial lung disease10.0TNF
44polymyositis10.0CCR5
45psoriatic arthritis10.0TNF
46periodontal disease10.0TNF
47ankylosing spondylitis10.0TNF
48coronary heart disease10.0CCR5
49crohn's disease10.0TNF
50pleurisy10.0IL2RA

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to intermediate uveitis

Clinical Features for Intermediate Uveitis

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Drugs & Therapeutics for Intermediate Uveitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intermediate Uveitis

Drug clinical trials:

Search ClinicalTrials for Intermediate Uveitis

Search NIH Clinical Center for Intermediate Uveitis

Search CenterWatch for Intermediate Uveitis

Genetic Tests for Intermediate Uveitis

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Anatomical Context for Intermediate Uveitis

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32MalaCards
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MalaCards organs/tissues related to Intermediate Uveitis:

32
Eye, Retina, T cells, B cells

Animal Models for Intermediate Uveitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intermediate Uveitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.9CD69
2MP:00053889.8CXCR3
3MP:00020068.2IL10, CCR5, CXCR3, IFNG, TNF
4MP:00053818.1CCR5, IFNG, TNF, IL2RA, IL10
5MP:00053847.2TNF, IFNG, CCR5, CXCR3, IL2RA, IL10
6MP:00053976.9CCR4, CCR5, IFNG, TNF, CD69, IL2RA
7MP:00053876.6IFNG, CCR4, CCR5, TNF, CD69, CXCR3

Publications for Intermediate Uveitis

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50PubMed
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Articles related to Intermediate Uveitis:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Role of IL-10 gene polymorphisms in intermediate and HLA-B27-associated uveitis. (23506437)
2013
2
Intermediate uveitis, an ophthalmological manifestation of systemic disease. (23238072)
2013
3
Laser photocoagulation in intermediate uveitis associated with retinoschisis. (22827157)
2012
4
Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis. (22876110)
2012
5
Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis. (20735295)
2011
6
Intraocular and serum cytokine profiles in patients with intermediate uveitis. (21850175)
2011
7
Young age as a risk factor for complicated course and visual outcome in intermediate uveitis in children. (20921016)
2011
8
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
9
Nonprogressive tractional inferior retinal elevation in intermediate uveitis. (20128653)
2010
10
Intermediate uveitis. (20029143)
2010
11
Intermediate uveitis and arthralgia as early symptoms in Whipple's disease. (20400351)
2010
12
Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. (19241289)
2009
13
Intermediate uveitis: long-term course and visual outcome. (19066184)
2009
14
Idiopathic intermediate uveitis in childhood. (18645400)
2008
15
Intermediate uveitis complicated by choroidal granuloma following subretinal neovascular membrane: case reports. (19169529)
2008
16
Intravitreal triamcinolone for the treatment of refractory macular edema in idiopathic intermediate or posterior uveitis. (18465727)
2008
17
Dislocation of in-the-bag posterior chamber intraocular lens in a patient with intermediate uveitis. (17361270)
2007
18
Concurrent intermediate uveitis and an enhancing intracranial lesion as the initial manifestation of sarcoidosis. (16710498)
2006
19
Combined 50- and 20-MHz frequency ultrasound imaging in intermediate uveitis. (16678517)
2006
20
The use of low dose methotrexate in children with chronic anterior and intermediate uveitis. (15965154)
2005
21
Are cytokine gene polymorphisms associated with outcome in patients with idiopathic intermediate uveitis in the United Kingdom? (16024856)
2005
22
Bilateral dislocation of in-the-bag posterior chamber intraocular lenses in a patient with intermediate uveitis. (14604727)
2003
23
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
24
Acute allergy reaction after posterior sub-Tenon's triamcinolone injection in the treatment of intermediate uveitis in the asthmatic patient. (15314977)
2003
25
Metastatic cutaneous melanoma to the vitreous cavity masquerading as intermediate uveitis. (12220005)
2002
26
Pars plana vitrectomy in patients with intermediate uveitis. (11815883)
2001
27
Pars-plana vitrectomy in cystoid macular edema associated with intermediate uveitis. (11521690)
2001
28
Chronic Propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. (9145695)
1997
29
Course and complications of intermediate uveitis. (9088408)
1997
30
Intermediate uveitis and retinal vasculitis as manifestations of cat scratch disease. (8862061)
1996
31
Association of intermediate uveitis with HLA-A28: definition of a new systemic syndrome? (7622075)
1995
32
The effects of posterior subtenon injection of triamcinolone acetonide in patients with intermediate uveitis. (7611330)
1995
33
Vitreoretinal surgery in intermediate uveitis. (7728108)
1995
34
Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases? (7711475)
1994
35
In search of intraocular antibody production to parvo B19 virus and adenovirus in intermediate uveitis. (8110689)
1993
36
Corticosteroids in the treatment of intermediate uveitis. (1730352)
1992
37
Plasma exchange and immunoglobulins in the treatment of intermediate uveitis. (1730368)
1992
38
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
39
Fluorescein angiography in intermediate uveitis. (1730346)
1992
40
Intermediate uveitis and Lyme borreliosis. (1540569)
1992
41
HLA in intermediate uveitis. (1730372)
1992
42
Do HLA antigens play a role in intermediate uveitis? (1481478)
1992
43
Opening address: intermediate uveitis. (1730339)
1992
44
International workshop on intermediate uveitis, GA1tersloh, July 5-6, 1990. (1346119)
1992
45
Biomicroscopy in intermediate uveitis. (1730369)
1992
46
Intermediate uveitis and focal infection. (1730343)
1992
47
Intermediate uveitis: epidemiology, age and sex distribution. (1730379)
1992
48
Surgical treatment of intermediate uveitis. (1730355)
1992
49
Light as alternative treatment of intermediate uveitis and chronic iridocyclitis. (1730367)
1992
50
Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. (4000641)
1985

Genetic Variations for Intermediate Uveitis

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Expression for genes affiliated with Intermediate Uveitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermediate Uveitis

Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for genes affiliated with Intermediate Uveitis

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems
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Pathways related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1CCR5
2
Hide members
10.1IL2RA
310.1IL2RA
49.6IFNG, IL2RA
59.6IL2RA, IFNG
69.5IL10, IFNG
79.4IFNG, TNF
89.3TNF, IL10
9
Hide members
9.2IL2RA, IFNG, CCR5
109.1IL10, IL2RA, IFNG
11
Hide members
9.0CCR5, IFNG, TNF
12
Hide members
9.0IL2RA, TNF, IFNG
139.0IL2RA, TNF, IFNG
14
Hide members
8.9CXCR3, CCR5, CCR4
158.9CCR4, CCR5, CXCR3
16
Hide members
8.9CXCR3, CCR5, CCR4
17
Hide members
8.9CXCR3, CCR5, CCR4
18
Hide members
8.9IFNG, TNF, IL10
19
Hide members
8.9IFNG, TNF, IL10
208.9IFNG, TNF, IL10
218.9IFNG, TNF, IL10
228.9IFNG, TNF, IL10
23
Development PDGF signaling via STATs and NF-kB
Hide members
8.9IL10, TNF, IFNG
24
Hide members
8.9IFNG, TNF, IL10
258.9IL10, TNF, IFNG
26
Hide members
8.5CCR4, CCR5, CXCR3, IL2RA
27
Hide members
8.5CCR4, CCR5, CXCR3, IL2RA
28
Hide members
8.5CCR5, IFNG, TNF, IL10
29
Hide members
8.5IL10, IL2RA, TNF, IFNG
30
Hide members
8.5IFNG, TNF, IL2RA, IL10
31
Hide members
7.4CCR4, CCR5, TNF, CXCR3, IL2RA, IL10

Compounds for genes affiliated with Intermediate Uveitis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.4CXCR3
2ivig4410.1CCR5, IFNG
3ccl11289.9CCR5, CXCR3
4ccl13289.9CXCR3, CCR5
52,5-oligoadenylate449.9IL2RA, TNF
6ccl5289.8CXCR3, CCR5
7ccl7289.8CXCR3, CCR5
8prednisolone44 28 1111.7CCR4, IL2RA
9cyclosporin a44 28 5911.5CD69, IL2RA, IFNG
10gold sodium thiomalate449.3TNF, IL2RA, IFNG
11mip 1alpha449.3IL10, CCR5, TNF
12mycophenolate mofetil44 49 1111.3IL2RA, IL10, IFNG
13larc449.3CCR5, CXCR3, CCR4
14interferon gamma449.3TNF, IFNG, IL10
155 aminosalicylic acid449.3IL10, IL2RA, TNF
16adalimumab44 49 1111.2IFNG, IL10, TNF
17il-12449.2IL10, IFNG, TNF
18imiquimod44 28 59 1112.2IFNG, TNF, IL10
19polymyxin b449.2IL10, TNF, IFNG
20ribavirin44 49 1111.2IFNG, CXCR3, IL10, CCR5
21gm-csf44 2810.2TNF, IFNG, IL10
22polyinosinic-polycytidylic acid449.1IFNG, TNF, IL10
23ifn-alpha449.1IL2RA, IL10, CXCR3, IFNG
24poly(i-c)449.1TNF, IFNG, CD69
25rantes449.1CXCR3, TNF, IFNG, IL2RA
26ccl444 2810.1CXCR3, CCR5, CCR4
27groalpha449.0CXCR3, IL10, TNF, CCR5
28allergens449.0CD69, IFNG, IL10, CXCR3
29tuberculin449.0IL10, CD69, IL2RA, IFNG
30con a449.0IFNG, CD69, IL2RA, IL10
31etanercept44 49 1110.9TNF, CXCR3, IFNG, IL10
32natalizumab44 119.9IFNG, IL10, IL2RA, TNF
33okt3448.9IFNG, TNF, IL2RA, IL10
3415-deoxy-delta-12,14-prostaglandin j2448.9IL10, TNF, IFNG
35neopterin448.8IL2RA, IL10, TNF, IFNG
36thalidomide44 49 59 1111.8TNF, IL2RA, IL10, IFNG
37herbimycin a44 599.8IL2RA, CD69, TNF, IFNG
38calcitriol44 59 11 2411.7IL2RA, TNF, IFNG, IL10
39methotrexate44 49 1110.6IL10, IL2RA, TNF, CD69
40rituximab44 49 1110.6IL10, TNF, IL2RA
41infliximab44 49 1110.6IL10, TNF, IFNG, IL2RA, CXCR3
42ionomycin448.3IL10, IFNG, CD69, IL2RA, TNF
43il 10448.2CCR5, IFNG, TNF, CXCR3, IL2RA, IL10
44histamine44 28 2410.2CCR5, IFNG, TNF, CXCR3, IL2RA, IL10
45simvastatin44 49 59 28 11 2413.1TNF, IFNG, CCR5, CCR4, IL10
46tacrolimus44 49 1110.0TNF, IFNG, IL2RA, IL10, CD69, CXCR3
47vegf448.0IL2RA, CXCR3, IFNG, TNF, IL10
48thymidine44 249.0IL10, IL2RA, IFNG, TNF, CXCR3, CD69
49tarc447.8CXCR3, TNF, IFNG, CCR5, IL10, CCR4
50ccl344 288.8TNF, IFNG, CCR4, CCR5, CXCR3, IL10

GO Terms for genes affiliated with Intermediate Uveitis

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16Gene Ontology
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Cellular components related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058877.8CXCR3, CD69, TNF, CCR5, CCR4
2external side of plasma membraneGO:0098976.6IL2RA, CCR4, CCR5, IFNG, TNF, CD69

Biological processes related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG
2positive regulation of vitamin D biosynthetic processGO:0605579.7TNF, IFNG
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IFNG
4positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IFNG
5receptor biosynthetic processGO:0328009.7IL10, TNF
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.6TNF, IFNG
7negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
8positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
9protein import into nucleus, translocationGO:0000609.5TNF, IFNG
10negative regulation of interleukin-6 productionGO:0327159.5TNF, IL10
11calcium-mediated signalingGO:0197229.5CCR5, TNF, CXCR3
12chemokine-mediated signaling pathwayGO:0700989.5CCR5, CCR4
13cellular response to lipopolysaccharideGO:0712229.4CCR5, IFNG, IL10
14extrinsic apoptotic signaling pathwayGO:0971919.4IFNG, TNF
15response to activityGO:0148239.4IL10, TNF
16positive regulation of nitric oxide biosynthetic processGO:0454299.4TNF, IFNG
17negative regulation of T cell proliferationGO:0421309.2IL10, IL2RA
18cell surface receptor signaling pathwayGO:0071669.2IL2RA, CXCR3, IFNG, CCR5
19positive regulation of cytokine secretionGO:0507159.2TNF, IL10
20negative regulation of growth of symbiont in hostGO:0441309.2IFNG, TNF, IL10
21elevation of cytosolic calcium ion concentrationGO:0072049.2CCR4, CCR5, CXCR3
22chemotaxisGO:0069359.2CXCR3, CCR5, CCR4
23apoptotic processGO:0069158.8IFNG, TNF, CXCR3, IL2RA
24inflammatory responseGO:0069548.2IL10, CXCR3, TNF, CCR5, CCR4

Molecular functions related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.0CCR5, CCR4
2cytokine activityGO:0051258.9IL10, TNF, IFNG
3chemokine receptor activityGO:0049508.8CXCR3, CCR5, CCR4

Products for genes affiliated with Intermediate Uveitis

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  • Antibodies
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Sources for Intermediate Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet