MCID: INT064
MIFTS: 46

Intermediate Uveitis malady

Rare diseases category

Summaries for Intermediate Uveitis

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Wikipedia:63 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

MalaCards based summary: Intermediate Uveitis, also known as peripheral uveoretinitis, is related to uveitis and eosinophilia. An important gene associated with Intermediate Uveitis is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are IL12 signaling mediated by STAT4 and Inflammatory Response Pathway. The compounds gold sodium thiomalate and mip 1alpha have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Intermediate Uveitis

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Intermediate Uveitis, Aliases & Descriptions:

Name: Intermediate Uveitis 9
Peripheral Uveoretinitis 9
Uveitis, Intermediate 60
 
Uveitis Intermediate 43
Chronic Cyclitis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:12732
MeSH33 D015867
NCIt38 C35110

Related Diseases for Intermediate Uveitis

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Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
intermediate uveitis Anterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.0TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA
2eosinophilia29.4CCR4, IFNG, IL2RA, IL10, CD69
3melanoma29.1TNF, CXCR3, CCR5, CCR4, IFNG, IL10
4tuberculosis28.8TNF, CXCR3, CCR4, IFNG, IL2RA, IL10
5pars planitis10.6
6coccidioidomycosis10.5CD69
7retinitis10.5
8farmer's lung10.4IL2RA
9blau syndrome10.4TNF
10pleurisy10.4IL2RA
11wegener granulomatosis10.4CCR5
12contact dermatitis10.3CCR4, CXCR3
13lymphomatoid papulosis10.3CXCR3, CCR4
14cataract10.3
15skin disease10.3IL2RA
16allergic contact dermatitis10.3CCR4, CXCR3
17reticulosarcoma10.3CCR4, CXCR3
18oral lichen planus10.3CCR5, CXCR3
19retinal vasculitis10.2
20choroiditis10.2
21endophthalmitis10.2
22vasculitis10.2
23extrinsic allergic alveolitis10.2CXCR3, IL2RA
24hcl-v10.2IL2RA, CXCR3
25hypereosinophilic syndrome10.2CD69, IL2RA
26mastocytosis10.2CD69, IL2RA
27aids dementia complex10.2CCR5, TNF
28central nervous system disease10.2CXCR3, CCR5
29pleural tuberculosis10.1IL2RA, IFNG
30peripheral t-cell lymphoma10.1IL2RA, CCR4, CXCR3
31juvenile rheumatoid arthritis10.1TNF, IL2RA
32mycosis fungoides10.1IL2RA, CCR4, CXCR3
33tropical spastic paraparesis10.1IL2RA, IFNG
34anaplastic large cell lymphoma10.1CXCR3, CCR4, IL2RA
35peritonitis10.1TNF, CD69
36periapical granuloma10.1CXCR3, CCR5, IL2RA
37pneumonia10.1IL10, TNF
38arthropathy10.1CD69, TNF
39retinoschisis10.1
40hodgkin lymphoma10.1
41acne10.1
42alopecia10.1
43granuloma annulare10.1
44rubella10.1
45posterior uveitis10.1
46cat-scratch disease10.1
47acute disseminated encephalomyelitis10.1
48alopecia areata10.1
49iridocyclitis10.1
50sjogren's syndrome10.1IL2RA, CXCR3

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to intermediate uveitis

Symptoms for Intermediate Uveitis

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Drugs & Therapeutics for Intermediate Uveitis

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Drug clinical trials:

Search ClinicalTrials for Intermediate Uveitis

Search NIH Clinical Center for Intermediate Uveitis

Genetic Tests for Intermediate Uveitis

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Anatomical Context for Intermediate Uveitis

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MalaCards organs/tissues related to Intermediate Uveitis:

31
Eye, Retina, T cells, B cells

Animal Models for Intermediate Uveitis or affiliated genes

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MGI Mouse Phenotypes related to Intermediate Uveitis:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5IL10, IFNG, CCR5, TNF
2MP:00053708.4IL10, IFNG, CCR5, TNF
3MP:00020068.4TNF, CXCR3, CCR5, IFNG, IL10
4MP:00053818.2TNF, CCR5, IFNG, IL2RA, IL10
5MP:00053858.2TNF, CXCR3, CCR5, IFNG, IL10
6MP:00053918.2TNF, CCR5, IFNG, IL10
7MP:00030128.2CD69, IL10, IFNG, CCR5, TNF
8MP:00053887.9TNF, CXCR3, CCR4, IFNG, IL10
9MP:00107687.7TNF, CXCR3, CCR5, IFNG, IL2RA, IL10
10MP:00053847.7TNF, CXCR3, CCR5, IFNG, IL10, CD69
11MP:00053976.7CD69, TNF, CXCR3, CCR5, CCR4, IFNG
12MP:00053876.6TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA

Publications for Intermediate Uveitis

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Articles related to Intermediate Uveitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Association analysis of TGFBR3 gene with BehAset's disease and idiopathic intermediate uveitis in a Caucasian population. (25677673)
2015
2
Unilateral snow banking in tuberculosis-related intermediate uveitis. (24507077)
2014
3
Retinal hemorrhages and intermediate uveitis in a patient with drug reaction with eosinophilia and systemic symptoms syndrome: a case report. (25372334)
2014
4
Tumor necrosis factor polymorphisms associated with tumor necrosis factor production influence the risk of idiopathic intermediate uveitis. (23378732)
2013
5
Interferon versus methotrexate in intermediate uveitis with macular edema: results of a randomized controlled clinical trial. (23786783)
2013
6
Intermediate uveitis, an ophthalmological manifestation of systemic disease. (23238072)
2013
7
Sarcoid intermediate uveitis following etanercept treatment: a case report and review of the literature. (22017171)
2012
8
Intermediate uveitis in Indian population. (21484178)
2011
9
Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant. (21273539)
2011
10
Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis. (20735295)
2011
11
Intraocular and serum cytokine profiles in patients with intermediate uveitis. (21850175)
2011
12
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
13
Nonprogressive tractional inferior retinal elevation in intermediate uveitis. (20128653)
2010
14
Intermediate uveitis. (20029143)
2010
15
Clinical characteristics of intermediate uveitis in Tunisian patients. (20204460)
2010
16
Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. (19241289)
2009
17
Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis. (18321467)
2008
18
Dislocation of in-the-bag posterior chamber intraocular lens in a patient with intermediate uveitis. (17361270)
2007
19
Prospective optical coherence tomographic evaluation of the efficacy of oral and posterior subtenon corticosteroids in patients with intermediate uveitis. (16896918)
2007
20
Nonsteroidal drugs for the treatment of noninfectious posterior and intermediate uveitis. (17435428)
2007
21
Concurrent intermediate uveitis and an enhancing intracranial lesion as the initial manifestation of sarcoidosis. (16710498)
2006
22
Intermediate uveitis. (16282148)
2005
23
Quality of life and visual function in patients with intermediate uveitis. (16113373)
2005
24
Intermediate uveitis: a hospital based study. (16388249)
2004
25
Bilateral dislocation of in-the-bag posterior chamber intraocular lenses in a patient with intermediate uveitis. (14604727)
2003
26
Intermediate uveitis in childhood preceding the diagnosis of multiple sclerosis: a 13-year follow-up. (12788130)
2003
27
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
28
Pars plana vitrectomy in patients with intermediate uveitis. (11815883)
2001
29
Search for autoantibodies against the HNK-1 carbohydrate epitope in the human eye in intermediate uveitis. (11037910)
2000
30
Ultrasound biomicroscopic imaging in intermediate uveitis. (9797661)
1998
31
The association of HLA-DR15 and intermediate uveitis. (9186099)
1997
32
Chronic Propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. (9145695)
1997
33
Long-term results of pars plana vitrectomy in the management of intermediate uveitis. (10163465)
1996
34
Association of intermediate uveitis with HLA-A28: definition of a new systemic syndrome? (7622075)
1995
35
Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases? (7711475)
1994
36
In search of intraocular antibody production to parvo B19 virus and adenovirus in intermediate uveitis. (8110689)
1993
37
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
38
Corticosteroids in the treatment of intermediate uveitis. (1730352)
1992
39
Plasma exchange and immunoglobulins in the treatment of intermediate uveitis. (1730368)
1992
40
Serological evidence of an association between Lyme borreliosis and intermediate uveitis. (1730342)
1992
41
Diseases masquerading intermediate uveitis. (1730373)
1992
42
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
43
Clinical picture of intermediate uveitis. (1730358)
1992
44
Intermediate uveitis and multiple sclerosis: considerations and necessary consequences for treatment. (1730341)
1992
45
Diagnostic vitrectomy in intermediate uveitis. (1730344)
1992
46
Intermediate uveitis and Lyme borreliosis. (1540569)
1992
47
HLA in intermediate uveitis. (1730372)
1992
48
Cataract extraction in intermediate uveitis. (1730359)
1992
49
Laser photocoagulation of retinal neovascularization in intermediate uveitis. (1730365)
1992
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Variations for Intermediate Uveitis

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Expression for genes affiliated with Intermediate Uveitis

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Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for genes affiliated with Intermediate Uveitis

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Pathways related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL2RA, IFNG
29.6IL2RA, IFNG
3
Show member pathways
IL-2 Signaling pathway36
9.6IL2RA, IFNG
49.6IL2RA, IFNG
59.5IL10, IFNG
69.4IFNG, TNF
7
Show member pathways
9.4IFNG, TNF
89.4TNF, IFNG
99.4IFNG, TNF
109.4IFNG, TNF
119.3IL10, TNF
129.3IL10, TNF
13
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.2IL2RA, IFNG, CCR5
14
Show member pathways
Type III interferon signaling36
9.1IL10, IL2RA, IFNG
15
Show member pathways
9.0TNF, CCR5, IFNG
16
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0TNF, IFNG, IL2RA
17
Show member pathways
9.0IL2RA, IFNG, TNF
18
Show member pathways
9.0TNF, IFNG, IL2RA
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.0IL2RA, IFNG, TNF
20
Show member pathways
8.9CXCR3, CCR5, CCR4
21
Show member pathways
8.9CXCR3, CCR5, CCR4
22
Show member pathways
8.9IL10, IFNG, TNF
238.9IL10, IFNG, TNF
248.9IL10, IFNG, TNF
25
Show member pathways
IL27-mediated signaling events36
8.9IL10, IFNG, TNF
26
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.9IL10, IFNG, TNF
278.9IL10, IFNG, TNF
288.9TNF, IFNG, IL10
298.9TNF, IFNG, IL10
30
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9TNF, IFNG, IL10
318.9TNF, IFNG, IL10
32
Show member pathways
8.5IL10, IFNG, CCR5, TNF
33
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.5TNF, CCR5, IFNG, IL10
34
Show member pathways
8.5IL10, IL2RA, IFNG, TNF
35
Show member pathways
8.5TNF, IFNG, IL2RA, IL10
36
Show member pathways
8.5TNF, IFNG, IL2RA, IL10
37
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
38
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
39
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
40
Show member pathways
6.9IL10, IL2RA, IFNG, CCR4, CCR5, CXCR3

Compounds for genes affiliated with Intermediate Uveitis

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Compounds related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate439.3IL2RA, TNF, IFNG
2mip 1alpha439.3IL10, TNF, CCR5
3larc439.2CCR4, CXCR3, CCR5
4interferon gamma439.2IFNG, IL10, TNF
55 aminosalicylic acid439.2IL10, TNF, IL2RA
6il-12439.2TNF, IFNG, IL10
7ribavirin43 49 1211.2CXCR3, IFNG, IL10, CCR5
8adalimumab43 49 1211.1IL10, IFNG, TNF
9indoleamine439.1TNF, IFNG, IL10
10imiquimod43 59 28 1212.1TNF, IL10, IFNG
11ifn-alpha439.1IL10, IL2RA, IFNG, CXCR3
12polymyxin b439.1IL10, IFNG, TNF
13gm-csf43 2810.0TNF, IFNG, IL10
14groalpha439.0TNF, CXCR3, CCR5, IL10
15tuberculin439.0IL10, IFNG, IL2RA, CD69
16allergens439.0CD69, CXCR3, IFNG, IL10
17con a439.0CD69, IL10, IL2RA, IFNG
18polyinosinic-polycytidylic acid438.9IL10, IFNG, TNF
19etanercept43 49 1210.9IL10, IFNG, CXCR3, TNF
20natalizumab43 129.9IL10, IL2RA, IFNG, TNF
21rolipram43 59 2810.9TNF, IFNG, IL10
22okt3438.9IL10, IL2RA, IFNG, TNF
232,5-oligoadenylate438.9IL10, TNF, IL2RA, IFNG
24hydrocortisone43 2 59 1211.9CXCR3, IL10, IFNG, TNF
25mycophenolate mofetil43 49 1210.8IL2RA, IL10, IFNG, TNF
26pentoxifylline43 129.8IL10, IL2RA, TNF, IFNG
27neopterin438.8TNF, IL10, IL2RA, IFNG
28thalidomide43 49 59 1211.8IL2RA, TNF, IL10, IFNG
29endotoxin438.8CXCR3, IL10, IFNG, TNF
30herbimycin a43 599.7CD69, TNF, IFNG, IL2RA
31calcitriol43 59 24 1211.6TNF, IL2RA, IL10, IFNG
32poly(i-c)438.6CD69, TNF, IFNG
33infliximab43 49 1210.6IL10, IL2RA, CXCR3, IFNG, TNF
34ivig438.5TNF, IL10, IL2RA, IFNG, CCR5
35methotrexate49 43 1210.5CD69, IL2RA, TNF, IL10
36ionomycin438.3IL10, CD69, IL2RA, IFNG, TNF
37il 10438.2TNF, IL10, IL2RA, IFNG, CCR5, CXCR3
38histamine43 28 2410.2CCR5, CXCR3, TNF, IL2RA, IL10, IFNG
39simvastatin43 49 59 28 24 1213.1CCR5, TNF, IL10, CCR4, IFNG
40prednisolone43 28 1210.1TNF, CCR4, IFNG, IL2RA, IL10
41tacrolimus43 49 1210.0IL10, CXCR3, IFNG, CD69, TNF, IL2RA
42vegf438.0TNF, IL2RA, IL10, IFNG, CXCR3
43nitric oxide43 24 1210.0IL10, CXCR3, TNF, CD69, IFNG
44thymidine43 249.0IL2RA, TNF, IFNG, IL10, CD69, CXCR3
45cyclosporin a43 28 5910.0IL10, IFNG, IL2RA, CD69, CCR5, TNF
46tarc437.8TNF, CCR5, CCR4, IFNG, IL10, CXCR3
47ccl343 288.8CCR5, IL10, IFNG, CCR4, CXCR3, TNF
48pge2437.7IFNG, IL2RA, IL10, CD69, CXCR3, TNF
49dexamethasone43 49 28 1210.7IFNG, CD69, IL2RA, CXCR3, CCR5, TNF
50rantes437.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10

GO Terms for genes affiliated with Intermediate Uveitis

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Cellular components related to Intermediate Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.8CD69, CCR4, CCR5, CXCR3, TNF
2external side of plasma membraneGO:00098976.6CD69, TNF, CXCR3, CCR5, CCR4, IFNG

Biological processes related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:00453489.8IL10, IFNG
2positive regulation of vitamin D biosynthetic processGO:00605579.8IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:00605599.8TNF, IFNG
4positive regulation of chemokine biosynthetic processGO:00450809.7IFNG, TNF
5negative regulation of T cell proliferationGO:00421309.7IL10, IL2RA
6positive regulation of membrane protein ectodomain proteolysisGO:00510449.7IFNG, TNF
7receptor biosynthetic processGO:00328009.7TNF, IL10
8negative regulation of cytokine secretion involved in immune responseGO:00027409.7TNF, IL10
9positive regulation of osteoclast differentiationGO:00456729.7TNF, IFNG
10protein import into nucleus, translocationGO:00000609.7IFNG, TNF
11negative regulation of interleukin-6 productionGO:00327159.6IL10, TNF
12positive regulation of cytokine secretionGO:00507159.6TNF, IL10
13positive regulation of nitric oxide biosynthetic processGO:00454299.5IFNG, TNF
14response to activityGO:00148239.5TNF, IL10
15calcium-mediated signalingGO:00197229.5CCR5, CXCR3, TNF
16chemokine-mediated signaling pathwayGO:00700989.5CCR4, CCR5
17cellular response to lipopolysaccharideGO:00712229.5IL10, IFNG, CCR5
18extrinsic apoptotic signaling pathwayGO:00971919.5TNF, IFNG
19response to glucocorticoidGO:00513849.3IL10, TNF
20humoral immune responseGO:00069599.3TNF, IFNG
21cell surface receptor signaling pathwayGO:00071669.3CXCR3, CCR5, IFNG, IL2RA
22positive regulation of cytosolic calcium ion concentrationGO:00072049.3CXCR3, CCR5, CCR4
23negative regulation of growth of symbiont in hostGO:00441309.3TNF, IFNG, IL10
24chemotaxisGO:00069359.3CCR4, CCR5, CXCR3
25MAPK cascadeGO:00001659.2CCR5, TNF
26response to drugGO:00424939.0IL10, IFNG, TNF
27apoptotic processGO:00069159.0TNF, CXCR3, IFNG, IL2RA
28immune responseGO:00069558.9IL2RA, CCR4, CCR5
29positive regulation of transcription from RNA polymerase II promoterGO:00459448.8IL10, IFNG, CXCR3, TNF
30inflammatory responseGO:00069548.2IL10, CCR4, CCR5, CXCR3, TNF

Molecular functions related to Intermediate Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:00164939.0CCR4, CCR5
2cytokine activityGO:00051258.9IL10, IFNG, TNF
3chemokine receptor activityGO:00049508.8CCR4, CCR5, CXCR3

Products for genes affiliated with Intermediate Uveitis

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Sources for Intermediate Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet