MCID: INT064
MIFTS: 55

Intermediate Uveitis malady

Eye diseases, Rare diseases categories
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Summaries for Intermediate Uveitis

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Wikipedia:65 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

MalaCards based summary: Intermediate Uveitis, also known as peripheral uveoretinitis, is related to pars planitis and uveitis. An important gene associated with Intermediate Uveitis is CXCR3 (chemokine (C-X-C motif) receptor 3), and among its related pathways are IL12 signaling mediated by STAT4 and Inflammatory Response Pathway. The compounds gold sodium thiomalate and mip 1alpha have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Intermediate Uveitis

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Intermediate Uveitis, Aliases & Descriptions:

Name: Intermediate Uveitis 8
Peripheral Uveoretinitis 8 62
Uveitis, Intermediate 62
 
Uveitis Intermediate 44
Chronic Cyclitis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:12732
NCIt39 C35110
MeSH34 D015867

Related Diseases for Intermediate Uveitis

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Diseases in the Intermediate Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Uveitis Anterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1pars planitis30.7IL2RA, CCR4, CCR5, CXCR3
2uveitis30.0TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA
3eosinophilia29.4CCR4, IFNG, IL2RA, IL10, CD69
4sarcoidosis29.3IL2RA, CD69, IFNG, CCR4, TNF, CXCR3
5melanoma29.1TNF, CXCR3, CCR5, CCR4, IFNG, IL10
6multiple sclerosis28.9CD69, TNF, CXCR3, CCR5, CCR4, IFNG
7tuberculosis28.8TNF, CXCR3, CCR4, IFNG, IL2RA, IL10
8coccidioidomycosis10.5CD69
9retinitis10.5
10farmer's lung10.4IL2RA
11blau syndrome10.4TNF
12pleurisy10.4IL2RA
13wegener's granulomatosis10.4CCR5
14contact dermatitis10.3CCR4, CXCR3
15lymphomatoid papulosis10.3CXCR3, CCR4
16skin disease10.3IL2RA
17cataract10.3
18allergic contact dermatitis10.3CCR4, CXCR3
19reticulosarcoma10.3CCR4, CXCR3
20oral lichen planus10.3CCR5, CXCR3
21cystoid macular edema10.2
22retinal vasculitis10.2
23choroiditis10.2
24vasculitis10.2
25extrinsic allergic alveolitis10.2CXCR3, IL2RA
26hairy cell leukemia10.2IL2RA, CXCR3
27hypereosinophilic syndrome10.2CD69, IL2RA
28mastocytosis10.2CD69, IL2RA
29aids dementia complex10.2CCR5, TNF
30central nervous system disease10.2CXCR3, CCR5
31pleural tuberculosis10.1IL2RA, IFNG
32peripheral t-cell lymphoma10.1IL2RA, CCR4, CXCR3
33juvenile rheumatoid arthritis10.1TNF, IL2RA
34mycosis fungoides10.1IL2RA, CCR4, CXCR3
35tropical spastic paraparesis10.1IL2RA, IFNG
36anaplastic large cell lymphoma10.1CXCR3, CCR4, IL2RA
37peritonitis10.1TNF, CD69
38periapical granuloma10.1CXCR3, CCR5, IL2RA
39pneumonia10.1IL10, TNF
40arthropathy10.1CD69, TNF
41sjogren's syndrome10.1IL2RA, CXCR3
42acne10.1
43alopecia10.1
44granuloma annulare10.1
45non-hodgkin lymphoma10.1
46posterior uveitis10.1
47rubella10.1
48cat-scratch disease10.1
49acute disseminated encephalomyelitis10.1
50alopecia areata10.1

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to intermediate uveitis

Symptoms for Intermediate Uveitis

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Drugs & Therapeutics for Intermediate Uveitis

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Drug clinical trials:

Search ClinicalTrials for Intermediate Uveitis

Search NIH Clinical Center for Intermediate Uveitis

Genetic Tests for Intermediate Uveitis

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Anatomical Context for Intermediate Uveitis

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MalaCards organs/tissues related to Intermediate Uveitis:

32
Eye, Retina, T cells, B cells

Animal Models for Intermediate Uveitis or affiliated genes

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MGI Mouse Phenotypes related to Intermediate Uveitis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5IL10, IFNG, CCR5, TNF
2MP:00053708.4IL10, IFNG, CCR5, TNF
3MP:00020068.4TNF, CXCR3, CCR5, IFNG, IL10
4MP:00053818.2TNF, CCR5, IFNG, IL2RA, IL10
5MP:00053858.2TNF, CXCR3, CCR5, IFNG, IL10
6MP:00053918.2TNF, CCR5, IFNG, IL10
7MP:00030128.2CD69, IL10, IFNG, CCR5, TNF
8MP:00053887.9TNF, CXCR3, CCR4, IFNG, IL10
9MP:00107687.7TNF, CXCR3, CCR5, IFNG, IL2RA, IL10
10MP:00053847.7TNF, CXCR3, CCR5, IFNG, IL10, CD69
11MP:00053976.7CD69, TNF, CXCR3, CCR5, CCR4, IFNG
12MP:00053876.6TNF, CXCR3, CCR5, CCR4, IFNG, IL2RA

Publications for Intermediate Uveitis

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Articles related to Intermediate Uveitis:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Unilateral snow banking in tuberculosis-related intermediate uveitis. (24507077)
2014
2
Retinal hemorrhages and intermediate uveitis in a patient with drug reaction with eosinophilia and systemic symptoms syndrome: a case report. (25372334)
2014
3
Tumor necrosis factor polymorphisms associated with tumor necrosis factor production influence the risk of idiopathic intermediate uveitis. (23378732)
2013
4
Interferon versus methotrexate in intermediate uveitis with macular edema: results of a randomized controlled clinical trial. (23786783)
2013
5
Intermediate uveitis, an ophthalmological manifestation of systemic disease. (23238072)
2013
6
Sarcoid intermediate uveitis following etanercept treatment: a case report and review of the literature. (22017171)
2012
7
Intermediate uveitis in Indian population. (21484178)
2011
8
Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant. (21273539)
2011
9
Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis. (20735295)
2011
10
Intraocular and serum cytokine profiles in patients with intermediate uveitis. (21850175)
2011
11
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
12
Nonprogressive tractional inferior retinal elevation in intermediate uveitis. (20128653)
2010
13
Intermediate uveitis. (20029143)
2010
14
DNA chip-assisted diagnosis of a previously unknown etiology of intermediate uveitis- Toxoplasma gondii. (20952843)
2010
15
Clinical characteristics of intermediate uveitis in Tunisian patients. (20204460)
2010
16
Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. (19241289)
2009
17
Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis. (18321467)
2008
18
Dislocation of in-the-bag posterior chamber intraocular lens in a patient with intermediate uveitis. (17361270)
2007
19
Prospective optical coherence tomographic evaluation of the efficacy of oral and posterior subtenon corticosteroids in patients with intermediate uveitis. (16896918)
2007
20
Nonsteroidal drugs for the treatment of noninfectious posterior and intermediate uveitis. (17435428)
2007
21
Intermediate uveitis. (16282148)
2005
22
Quality of life and visual function in patients with intermediate uveitis. (16113373)
2005
23
Intermediate uveitis: a hospital based study. (16388249)
2004
24
Bilateral dislocation of in-the-bag posterior chamber intraocular lenses in a patient with intermediate uveitis. (14604727)
2003
25
Intermediate uveitis in childhood preceding the diagnosis of multiple sclerosis: a 13-year follow-up. (12788130)
2003
26
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
27
Pars plana vitrectomy in patients with intermediate uveitis. (11815883)
2001
28
Search for autoantibodies against the HNK-1 carbohydrate epitope in the human eye in intermediate uveitis. (11037910)
2000
29
Ultrasound biomicroscopic imaging in intermediate uveitis. (9797661)
1998
30
The association of HLA-DR15 and intermediate uveitis. (9186099)
1997
31
Chronic Propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. (9145695)
1997
32
Long-term results of pars plana vitrectomy in the management of intermediate uveitis. (10163465)
1996
33
Association of intermediate uveitis with HLA-A28: definition of a new systemic syndrome? (7622075)
1995
34
Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases? (7711475)
1994
35
In search of intraocular antibody production to parvo B19 virus and adenovirus in intermediate uveitis. (8110689)
1993
36
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
37
Corticosteroids in the treatment of intermediate uveitis. (1730352)
1992
38
Plasma exchange and immunoglobulins in the treatment of intermediate uveitis. (1730368)
1992
39
Serological evidence of an association between Lyme borreliosis and intermediate uveitis. (1730342)
1992
40
Diseases masquerading intermediate uveitis. (1730373)
1992
41
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
42
Fluorescein angiography in intermediate uveitis. (1730346)
1992
43
Clinical picture of intermediate uveitis. (1730358)
1992
44
Intermediate uveitis and multiple sclerosis: considerations and necessary consequences for treatment. (1730341)
1992
45
Diagnostic vitrectomy in intermediate uveitis. (1730344)
1992
46
Intermediate uveitis and Lyme borreliosis. (1540569)
1992
47
HLA in intermediate uveitis. (1730372)
1992
48
Cataract extraction in intermediate uveitis. (1730359)
1992
49
Laser photocoagulation of retinal neovascularization in intermediate uveitis. (1730365)
1992
50
A clinical and histopathological review of intermediate uveitis ("pars planitis"). (3073831)
1988

Variations for Intermediate Uveitis

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Expression for genes affiliated with Intermediate Uveitis

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Expression patterns in normal tissues for genes affiliated with Intermediate Uveitis

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Pathways for genes affiliated with Intermediate Uveitis

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Pathways related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL2RA, IFNG
29.6IL2RA, IFNG
3
Show member pathways
IL-2 Signaling pathway37
9.6IL2RA, IFNG
49.6IL2RA, IFNG
59.5IL10, IFNG
69.4IFNG, TNF
7
Show member pathways
9.4IFNG, TNF
89.4TNF, IFNG
99.4IFNG, TNF
109.4IFNG, TNF
119.3IL10, TNF
129.3IL10, TNF
13
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.2IL2RA, IFNG, CCR5
14
Show member pathways
Type III interferon signaling37
9.1IL10, IL2RA, IFNG
15
Show member pathways
9.0TNF, CCR5, IFNG
16
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.0TNF, IFNG, IL2RA
17
Show member pathways
9.0IL2RA, IFNG, TNF
18
Show member pathways
9.0TNF, IFNG, IL2RA
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.0IL2RA, IFNG, TNF
20
Show member pathways
8.9CXCR3, CCR5, CCR4
21
Show member pathways
8.9CXCR3, CCR5, CCR4
22
Show member pathways
Peptide GPCRs37
8.9CXCR3, CCR5, CCR4
23
Show member pathways
8.9IL10, IFNG, TNF
248.9IL10, IFNG, TNF
258.9IL10, IFNG, TNF
26
Show member pathways
IL27-mediated signaling events37
8.9IL10, IFNG, TNF
27
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.9IL10, IFNG, TNF
288.9IL10, IFNG, TNF
298.9TNF, IFNG, IL10
308.9TNF, IFNG, IL10
31
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9TNF, IFNG, IL10
328.9TNF, IFNG, IL10
33
Show member pathways
8.5IL10, IFNG, CCR5, TNF
34
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.5TNF, CCR5, IFNG, IL10
35
Show member pathways
8.5IL10, IL2RA, IFNG, TNF
36
Show member pathways
8.5TNF, IFNG, IL2RA, IL10
37
Show member pathways
8.5TNF, IFNG, IL2RA, IL10
38
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
39
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
40
Show member pathways
7.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10
41
Show member pathways
6.9IL10, IL2RA, IFNG, CCR4, CCR5, CXCR3

Compounds for genes affiliated with Intermediate Uveitis

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Compounds related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate449.3IL2RA, TNF, IFNG
2mip 1alpha449.3IL10, TNF, CCR5
3larc449.2CCR4, CXCR3, CCR5
4interferon gamma449.2IFNG, IL10, TNF
55 aminosalicylic acid449.2IL10, TNF, IL2RA
6il-12449.2TNF, IFNG, IL10
7ribavirin44 50 1111.2CXCR3, IFNG, IL10, CCR5
8adalimumab44 50 1111.1IL10, IFNG, TNF
9indoleamine449.1TNF, IFNG, IL10
10imiquimod44 61 28 1112.1TNF, IL10, IFNG
11ifn-alpha449.1IL10, IL2RA, IFNG, CXCR3
12polymyxin b449.1IL10, IFNG, TNF
13gm-csf44 2810.0TNF, IFNG, IL10
14groalpha449.0TNF, CXCR3, CCR5, IL10
15tuberculin449.0IL10, IFNG, IL2RA, CD69
16allergens449.0CD69, CXCR3, IFNG, IL10
17con a449.0CD69, IL10, IL2RA, IFNG
18polyinosinic-polycytidylic acid448.9IL10, IFNG, TNF
19etanercept44 50 1110.9IL10, IFNG, CXCR3, TNF
20natalizumab44 119.9IL10, IL2RA, IFNG, TNF
21rolipram44 61 2810.9TNF, IFNG, IL10
22okt3448.9IL10, IL2RA, IFNG, TNF
232,5-oligoadenylate448.9IL10, TNF, IL2RA, IFNG
24hydrocortisone44 2 61 1111.9CXCR3, IL10, IFNG, TNF
25mycophenolate mofetil44 50 1110.8IL2RA, IL10, IFNG, TNF
26pentoxifylline44 119.8IL10, IL2RA, TNF, IFNG
27neopterin448.8TNF, IL10, IL2RA, IFNG
28thalidomide44 50 61 1111.8IL2RA, TNF, IL10, IFNG
29endotoxin448.8CXCR3, IL10, IFNG, TNF
30herbimycin a44 619.7CD69, TNF, IFNG, IL2RA
31calcitriol44 61 24 1111.6TNF, IL2RA, IL10, IFNG
32poly(i-c)448.6CD69, TNF, IFNG
33infliximab44 50 1110.6IL10, IL2RA, CXCR3, IFNG, TNF
34ivig448.5TNF, IL10, IL2RA, IFNG, CCR5
35methotrexate50 44 1110.5CD69, IL2RA, TNF, IL10
36ionomycin448.3IL10, CD69, IL2RA, IFNG, TNF
37il 10448.2TNF, IL10, IL2RA, IFNG, CCR5, CXCR3
38histamine44 28 2410.2CCR5, CXCR3, TNF, IL2RA, IL10, IFNG
39simvastatin44 50 61 28 24 1113.1CCR5, TNF, IL10, CCR4, IFNG
40prednisolone44 28 1110.1TNF, CCR4, IFNG, IL2RA, IL10
41tacrolimus44 50 1110.0IL10, CXCR3, IFNG, CD69, TNF, IL2RA
42vegf448.0TNF, IL2RA, IL10, IFNG, CXCR3
43nitric oxide44 24 1110.0IL10, CXCR3, TNF, CD69, IFNG
44thymidine44 249.0IL2RA, TNF, IFNG, IL10, CD69, CXCR3
45cyclosporin a44 28 6110.0IL10, IFNG, IL2RA, CD69, CCR5, TNF
46tarc447.8TNF, CCR5, CCR4, IFNG, IL10, CXCR3
47ccl344 288.8CCR5, IL10, IFNG, CCR4, CXCR3, TNF
48pge2447.7IFNG, IL2RA, IL10, CD69, CXCR3, TNF
49dexamethasone44 50 28 1110.7IFNG, CD69, IL2RA, CXCR3, CCR5, TNF
50rantes447.4TNF, CXCR3, CCR5, CCR4, IL2RA, IL10

GO Terms for genes affiliated with Intermediate Uveitis

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Cellular components related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.8CD69, CCR4, CCR5, CXCR3, TNF
2external side of plasma membraneGO:0098976.6CD69, TNF, CXCR3, CCR5, CCR4, IFNG

Biological processes related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG
2positive regulation of vitamin D biosynthetic processGO:0605579.8IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8TNF, IFNG
4positive regulation of chemokine biosynthetic processGO:0450809.7IFNG, TNF
5negative regulation of T cell proliferationGO:0421309.7IL10, IL2RA
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
7receptor biosynthetic processGO:0328009.7TNF, IL10
8negative regulation of cytokine secretion involved in immune responseGO:0027409.7TNF, IL10
9positive regulation of osteoclast differentiationGO:0456729.7TNF, IFNG
10protein import into nucleus, translocationGO:0000609.7IFNG, TNF
11negative regulation of interleukin-6 productionGO:0327159.6IL10, TNF
12positive regulation of cytokine secretionGO:0507159.6TNF, IL10
13positive regulation of nitric oxide biosynthetic processGO:0454299.5IFNG, TNF
14response to activityGO:0148239.5TNF, IL10
15calcium-mediated signalingGO:0197229.5CCR5, CXCR3, TNF
16chemokine-mediated signaling pathwayGO:0700989.5CCR4, CCR5
17cellular response to lipopolysaccharideGO:0712229.5IL10, IFNG, CCR5
18extrinsic apoptotic signaling pathwayGO:0971919.5TNF, IFNG
19response to glucocorticoidGO:0513849.3IL10, TNF
20humoral immune responseGO:0069599.3TNF, IFNG
21cell surface receptor signaling pathwayGO:0071669.3CXCR3, CCR5, IFNG, IL2RA
22positive regulation of cytosolic calcium ion concentrationGO:0072049.3CXCR3, CCR5, CCR4
23negative regulation of growth of symbiont in hostGO:0441309.3TNF, IFNG, IL10
24chemotaxisGO:0069359.3CCR4, CCR5, CXCR3
25MAPK cascadeGO:0001659.2CCR5, TNF
26response to drugGO:0424939.0IL10, IFNG, TNF
27apoptotic processGO:0069159.0TNF, CXCR3, IFNG, IL2RA
28immune responseGO:0069558.9IL2RA, CCR4, CCR5
29positive regulation of transcription from RNA polymerase II promoterGO:0459448.8IL10, IFNG, CXCR3, TNF
30inflammatory responseGO:0069548.2IL10, CCR4, CCR5, CXCR3, TNF

Molecular functions related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.0CCR4, CCR5
2cytokine activityGO:0051258.9IL10, IFNG, TNF
3chemokine receptor activityGO:0049508.8CCR4, CCR5, CXCR3

Products for genes affiliated with Intermediate Uveitis

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Sources for Intermediate Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet