MCID: INT064
MIFTS: 43

Intermediate Uveitis malady

Summaries for Intermediate Uveitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites... more...

MalaCards: Intermediate Uveitis, also known as peripheral uveoretinitis, is related to uveitis and vasculitis. An important gene associated with Intermediate Uveitis is PRRT2 (proline-rich transmembrane protein 2), and among its related pathways are Leishmaniasis and TGF-Beta Pathway. The compounds endotoxin and ivig have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and respiratory system.

Aliases & Classifications for Intermediate Uveitis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

intermediate uveitis 8
peripheral uveoretinitis 8
uveitis, intermediate 61
uveitis intermediate 45
chronic cyclitis 8


External Ids:

Disease Ontology8 DOID:12732
NCIt40 C35110
MeSH35 D015867

Related Diseases for Intermediate Uveitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the uveitis family:

infectious anterior uveitis posterior uveitis
intermediate uveitis anterior uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis31.5IL10, IL2RA, CXCR3, CD69, TNF, IFNG
2vasculitis30.3TNF
3alopecia areata30.0IFNG
4asthma30.0CCR4, CCR5, IFNG, TNF, CD69, CXCR3
5pars planitis10.5
6posterior uveitis10.5
7anterior uveitis10.4
8cystoid macular edema10.2
9retinal vasculitis10.2
10rubella10.0
11chronic endophthalmitis10.0
12whipple disease10.0
13granuloma annulare10.0
14acne10.0
15alopecia10.0
16nephritis10.0CXCR3
17lichen planus10.0CXCR3
18human immunodeficiency virus infectious disease10.0CD69
19bronchiolitis obliterans10.0CXCR3
20proliferative glomerulonephritis10.0CXCR3
21endometriosis10.0CD69
22coccidioidomycosis10.0CD69
23chagas disease10.0CCR5
24wegener's granulomatosis10.0CCR5
25glomerulonephritis10.0CCR5
26migraine10.0PRRT2
27acquired immunodeficiency syndrome10.0CCR5
28ovarian cancer10.0CD69
29alzheimer's disease10.0CXCR3
30guillain-barre syndrome10.0CCR5
31encephalitis10.0CCR5
32myocardial infarction10.0CCR5
33interstitial lung disease10.0TNF
34polymyositis10.0CCR5
35psoriatic arthritis10.0TNF
36periodontal disease10.0TNF
37ankylosing spondylitis10.0TNF
38coronary heart disease10.0CCR5
39crohn's disease10.0TNF
40pleurisy10.0IL2RA
41dementia10.0CCR5
42insulin resistance10.0TNF
43adenocarcinoma10.0CCR5
44familial mediterranean fever10.0TNF
45osteosarcoma10.0CCR5
46diabetes mellitus10.0TNF
47ulcerative colitis10.0TNF
48aspergillosis10.0IFNG
49obesity10.0TNF
50nephrotic syndrome10.0IL2RA

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to intermediate uveitis

Clinical Features for Intermediate Uveitis

Drugs & Therapeutics for Intermediate Uveitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intermediate Uveitis

Drug clinical trials:

Search ClinicalTrials for Intermediate Uveitis

Search NIH Clinical Center for Intermediate Uveitis

Search CenterWatch for Intermediate Uveitis

Genetic Tests for Intermediate Uveitis

Anatomical Context for Intermediate Uveitis

Animal Models for Intermediate Uveitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Intermediate Uveitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.9CD69
2MP:00053889.8CXCR3
3MP:00020068.2CCR5, IFNG, TNF, CXCR3, IL10
4MP:00053818.1IFNG, TNF, IL2RA, IL10, CCR5
5MP:00053847.2CCR5, IFNG, TNF, CD69, CXCR3, IL2RA
6MP:00053976.9CCR4, CCR5, IFNG, TNF, CD69, IL2RA
7MP:00053876.6IL10, CCR4, CCR5, IFNG, TNF, CD69

Publications for Intermediate Uveitis

Sources:
51PubMed
See all sources

Articles related to Intermediate Uveitis:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Vision-related functioning outcomes of dexamethasone intravitreal implant in noninfectious intermediate or posterior uveitis. (23761087)
2013
2
Psychometric evaluation of the National Eye Institute Visual Function Questionnaire and Visual Function Questionnaire Utility Index in patients with non-infectious intermediate and posterior uveitis. (23645458)
2013
3
Intermediate uveitis, an ophthalmological manifestation of systemic disease. (23238072)
2013
4
Laser photocoagulation in intermediate uveitis associated with retinoschisis. (22827157)
2012
5
Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis. (22876110)
2012
6
Intraocular and serum cytokine profiles in patients with intermediate uveitis. (21850175)
2011
7
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
8
Nonprogressive tractional inferior retinal elevation in intermediate uveitis. (20128653)
2010
9
Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography. (19241289)
2009
10
Intermediate uveitis: long-term course and visual outcome. (19066184)
2009
11
Intravitreal triamcinolone for the treatment of refractory macular edema in idiopathic intermediate or posterior uveitis. (18465727)
2008
12
Anterior and intermediate uveitis cases referred to a tertiary centre in Alberta. (18033328)
2007
13
Concurrent intermediate uveitis and an enhancing intracranial lesion as the initial manifestation of sarcoidosis. (16710498)
2006
14
Combined 50- and 20-MHz frequency ultrasound imaging in intermediate uveitis. (16678517)
2006
15
Intermediate uveitis. (16282148)
2005
16
Clinical features and visual outcome of intermediate uveitis in children. (15670074)
2005
17
Cyclosporine vs tacrolimus therapy for posterior and intermediate uveitis. (15883282)
2005
18
Intermediate uveitis in childhood preceding the diagnosis of multiple sclerosis: a 13-year follow-up. (12788130)
2003
19
Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (12770977)
2003
20
Acute allergy reaction after posterior sub-Tenon's triamcinolone injection in the treatment of intermediate uveitis in the asthmatic patient. (15314977)
2003
21
Metastatic cutaneous melanoma to the vitreous cavity masquerading as intermediate uveitis. (12220005)
2002
22
Intermediate uveitis. (12434479)
2002
23
Pars-plana vitrectomy in cystoid macular edema associated with intermediate uveitis. (11521690)
2001
24
Search for autoantibodies against the HNK-1 carbohydrate epitope in the human eye in intermediate uveitis. (11037910)
2000
25
Familial intermediate uveitis: a case report of two brothers. (10707159)
1999
26
Evaluation of cataract surgery in intermediate uveitis. (10100252)
1999
27
Intermediate uveitis of pars planitis type in identical twins. Report of a case. (10826543)
1998
28
The association of HLA-DR15 and intermediate uveitis. (9186099)
1997
29
Long-term results of pars plana vitrectomy in the management of intermediate uveitis. (10163465)
1996
30
Association of intermediate uveitis with HLA-A28: definition of a new systemic syndrome? (7622075)
1995
31
The effects of posterior subtenon injection of triamcinolone acetonide in patients with intermediate uveitis. (7611330)
1995
32
Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases? (7711475)
1994
33
In search of intraocular antibody production to parvo B19 virus and adenovirus in intermediate uveitis. (8110689)
1993
34
Antiretinal autoantibodies in intermediate uveitis. (1730380)
1992
35
Corticosteroids in the treatment of intermediate uveitis. (1730352)
1992
36
Diseases masquerading intermediate uveitis. (1730373)
1992
37
Intermediate uveitis: what is the significance of the pars plana exudate in 'pars planitis'? A summary. (1730374)
1992
38
Fluorescein angiography in intermediate uveitis. (1730346)
1992
39
Diagnostic vitrectomy in intermediate uveitis. (1730344)
1992
40
Intermediate uveitis and Lyme borreliosis. (1540569)
1992
41
Cataract extraction in intermediate uveitis. (1730359)
1992
42
Laser photocoagulation of retinal neovascularization in intermediate uveitis. (1730365)
1992
43
Epidemiology of intermediate uveitis: a prospective study in Savoy. (1730371)
1992
44
Intermediate uveitis and sarcoidosis. (1730340)
1992
45
Pathology of intermediate uveitis. (1730376)
1992
46
Intermediate uveitis and focal infection. (1730343)
1992
47
Intermediate uveitis: epidemiology, age and sex distribution. (1730379)
1992
48
Cellular phenotype of vitreous cells in intermediate uveitis. (1730347)
1992
49
Nonsteroid anti-inflammatory drugs in the treatment of intermediate uveitis. (1730351)
1992
50
Surgical treatment of intermediate uveitis. (1730355)
1992

Genetic Variations for Intermediate Uveitis

Expression for genes affiliated with Intermediate Uveitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intermediate Uveitis

Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for genes affiliated with Intermediate Uveitis

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems
See all sources

Pathways related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1CCR5
2
Hide members
10.1IL2RA
310.1IL2RA
49.6IFNG, IL2RA
59.6IL2RA, IFNG
69.5IL10, IFNG
79.4IFNG, TNF
89.3TNF, IL10
9
Hide members
9.2IL2RA, IFNG, CCR5
109.1IL10, IL2RA, IFNG
11
Hide members
9.0CCR5, IFNG, TNF
12
Hide members
9.0IL2RA, TNF, IFNG
139.0IL2RA, TNF, IFNG
14
Hide members
8.9CXCR3, CCR5, CCR4
158.9CCR4, CCR5, CXCR3
16
Hide members
8.9CXCR3, CCR5, CCR4
17
Hide members
8.9CXCR3, CCR5, CCR4
18
Hide members
8.9IFNG, TNF, IL10
19
Hide members
8.9IFNG, TNF, IL10
208.9IFNG, TNF, IL10
218.9IFNG, TNF, IL10
228.9IFNG, TNF, IL10
23
Development PDGF signaling via STATs and NF-kB
Hide members
8.9IL10, TNF, IFNG
24
Hide members
8.9IFNG, TNF, IL10
258.9IL10, TNF, IFNG
26
Hide members
8.5CCR4, CCR5, CXCR3, IL2RA
27
Hide members
8.5CCR4, CCR5, CXCR3, IL2RA
28
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8.5CCR5, IFNG, TNF, IL10
29
Hide members
8.5IL10, IL2RA, TNF, IFNG
30
Hide members
8.5IFNG, TNF, IL2RA, IL10
31
Hide members
7.4CCR4, CCR5, TNF, CXCR3, IL2RA, IL10

Compounds for genes affiliated with Intermediate Uveitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.4CXCR3
2ivig4510.1IFNG, CCR5
3ccl11299.9CCR5, CXCR3
4ccl7299.9CCR5, CXCR3
52,5-oligoadenylate459.9IL2RA, TNF
6ccl13299.8CCR5, CXCR3
7ccl5299.8CCR5, CXCR3
8prednisolone45 29 1111.7IL2RA, CCR4
9cyclosporin a45 29 6011.5IFNG, CD69, IL2RA
10gold sodium thiomalate459.3IFNG, TNF, IL2RA
11mip 1alpha459.3IL10, TNF, CCR5
12mycophenolate mofetil45 50 1111.3IL10, IL2RA, IFNG
13larc459.3CXCR3, CCR5, CCR4
14interferon gamma459.3IL10, TNF, IFNG
155 aminosalicylic acid459.3TNF, IL2RA, IL10
16adalimumab45 50 1111.2IFNG, TNF, IL10
17il-12459.2IFNG, TNF, IL10
18imiquimod45 29 60 1112.2IL10, TNF, IFNG
19polymyxin b459.2IFNG, TNF, IL10
20ribavirin45 50 1111.2CCR5, IFNG, CXCR3, IL10
21gm-csf45 2910.2IL10, TNF, IFNG
22polyinosinic-polycytidylic acid459.1IL10, TNF, IFNG
23ifn-alpha459.1IL10, IL2RA, CXCR3, IFNG
24rantes459.1IL2RA, CXCR3, TNF, IFNG
25ccl445 2910.1CXCR3, CCR5, CCR4
26poly(i-c)459.1CD69, TNF, IFNG
27groalpha459.0CCR5, TNF, CXCR3, IL10
28allergens459.0IFNG, CD69, CXCR3, IL10
29tuberculin459.0IFNG, CD69, IL2RA, IL10
30con a459.0IFNG, CD69, IL2RA, IL10
31etanercept45 50 1110.9IFNG, TNF, CXCR3, IL10
32natalizumab45 119.9IL10, IL2RA, TNF, IFNG
33okt3458.9IFNG, TNF, IL2RA, IL10
3415-deoxy-delta-12,14-prostaglandin j2458.9IL10, TNF, IFNG
35neopterin458.8IFNG, TNF, IL2RA, IL10
36thalidomide45 50 60 1111.8IFNG, TNF, IL2RA, IL10
37herbimycin a45 609.8IFNG, TNF, CD69, IL2RA
38calcitriol45 60 11 2411.7IFNG, TNF, IL2RA, IL10
39methotrexate45 50 1110.6TNF, CD69, IL2RA, IL10
40rituximab45 50 1110.6IL10, IL2RA, TNF
41infliximab45 50 1110.6IFNG, TNF, CXCR3, IL2RA, IL10
42ionomycin458.3IFNG, TNF, CD69, IL2RA, IL10
43il 10458.2IL10, IL2RA, CXCR3, TNF, IFNG, CCR5
44histamine45 29 2410.2CCR5, IFNG, TNF, CXCR3, IL2RA, IL10
45simvastatin45 50 60 29 11 2413.1IL10, TNF, IFNG, CCR5, CCR4
46tacrolimus45 50 1110.0IFNG, TNF, CD69, CXCR3, IL2RA, IL10
47vegf458.0IFNG, TNF, CXCR3, IL2RA, IL10
48thymidine45 249.0IFNG, TNF, CD69, CXCR3, IL2RA, IL10
49tarc457.8CCR4, CCR5, IFNG, TNF, CXCR3, IL10
50ccl345 298.8CCR4, CCR5, IFNG, TNF, CXCR3, IL10

GO Terms for genes affiliated with Intermediate Uveitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058877.8CXCR3, CD69, TNF, CCR5, CCR4
2external side of plasma membraneGO:0098976.6IL2RA, CCR4, CCR5, IFNG, TNF, CD69

Biological processes related to Intermediate Uveitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG
2positive regulation of vitamin D biosynthetic processGO:0605579.7TNF, IFNG
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IFNG
4positive regulation of chemokine biosynthetic processGO:0450809.7TNF, IFNG
5receptor biosynthetic processGO:0328009.7IL10, TNF
6positive regulation of membrane protein ectodomain proteolysisGO:0510449.6TNF, IFNG
7negative regulation of cytokine secretion involved in immune responseGO:0027409.6IL10, TNF
8positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
9protein import into nucleus, translocationGO:0000609.5TNF, IFNG
10negative regulation of interleukin-6 productionGO:0327159.5TNF, IL10
11calcium-mediated signalingGO:0197229.5CCR5, TNF, CXCR3
12chemokine-mediated signaling pathwayGO:0700989.5CCR5, CCR4
13cellular response to lipopolysaccharideGO:0712229.4CCR5, IFNG, IL10
14extrinsic apoptotic signaling pathwayGO:0971919.4IFNG, TNF
15response to activityGO:0148239.4IL10, TNF
16positive regulation of nitric oxide biosynthetic processGO:0454299.4TNF, IFNG
17negative regulation of T cell proliferationGO:0421309.2IL10, IL2RA
18cell surface receptor signaling pathwayGO:0071669.2IL2RA, CXCR3, IFNG, CCR5
19positive regulation of cytokine secretionGO:0507159.2TNF, IL10
20negative regulation of growth of symbiont in hostGO:0441309.2IFNG, TNF, IL10
21elevation of cytosolic calcium ion concentrationGO:0072049.2CCR4, CCR5, CXCR3
22chemotaxisGO:0069359.2CXCR3, CCR5, CCR4
23apoptotic processGO:0069158.8IFNG, TNF, CXCR3, IL2RA
24inflammatory responseGO:0069548.2IL10, CXCR3, TNF, CCR5, CCR4

Molecular functions related to Intermediate Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.0CCR5, CCR4
2cytokine activityGO:0051258.9IL10, TNF, IFNG
3chemokine receptor activityGO:0049508.8CXCR3, CCR5, CCR4

Products for genes affiliated with Intermediate Uveitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermediate Uveitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet