Aliases & Classifications for Intermittent Claudication

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Aliases & Descriptions for Intermittent Claudication:

Name: Intermittent Claudication 30 8 10 44 61
Intermittent Claudication Nos 8
 
Charcot's Syndrome 8


External Ids:

Disease Ontology8 DOID:3669
MeSH33 D007383

Summaries for Intermittent Claudication

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Wikipedia:64 Intermittent claudication (Latin: claudicatio intermittens) is a symptom that describes muscle pain... more...

MalaCards based summary: Intermittent Claudication, also known as intermittent claudication nos, is related to peripheral vascular disease and ischemia. An important gene associated with Intermittent Claudication is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Cell adhesion Plasmin signaling and Complement and coagulation cascades. The drugs pentoxifylline and cilostazol and the compounds sarpogrelate hydrochloride and sarpogrelate have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and bone, and related mouse phenotypes are skeleton and hematopoietic system.

Related Diseases for Intermittent Claudication

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Diseases related to Intermittent Claudication via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease30.7VWF, SELP
2ischemia30.5SELP, FGA, FGF2
3vascular disease30.3SELP, VWF, FGF2
4coronary artery disease30.1FGA, SELP
5atherosclerosis30.0SELP, FGA, VWF, FGF2
6myocardial infarction30.0FGA, HTR2A, SELP, VWF
7artery disease10.9
8peripheral artery disease10.9
9endotheliitis10.7
10blindness10.7
11spinal stenosis10.6
12limb ischemia10.6
13critical limb ischemia10.5
14cystic adventitial disease10.5
15arteriosclerosis10.4
16fibromuscular dysplasia10.4
17aneurysm10.4
18coronary thrombosis10.3VWF
19pseudoxanthoma elasticum10.3
20angina pectoris10.3
21arteriosclerosis obliterans10.3
22abdominal aortic aneurysm10.3
23aortic aneurysm10.3
24blood platelet disease10.2SELP, VWF
25von willebrand's disease10.1VWF, SELP
26hemophilia a10.1VWF, SELP
27obesity10.1
28lipoma10.1
29hyperoxaluria, primary, type 110.1
30arteriovenous fistula10.1
31spondylosis10.1
32neuronitis10.1
33systolic heart failure10.1
34carotid stenosis10.1
35amyloidosis10.1
36carotid artery disease10.1
37cervicitis10.1
38compartment syndrome10.1
39lymphangioma10.1
40pneumonia10.1
41hypoxia10.1
42proteinuria10.1
43thrombotic thrombocytopenic purpura, acquired10.1SELP, VWF
44essential thrombocythemia10.1VWF, SELP
45mitral valve stenosis10.1FGA, SELP
46antiphospholipid syndrome10.1VWF, SELP
47microvascular complications of diabetes 110.1SELP, FGF2
48intracranial thrombosis10.0VWF, FGA
49hyperhomocysteinemia10.0SELP, VWF
50brain disease10.0VWF, SELP, FGF2

Graphical network of the top 20 diseases related to Intermittent Claudication:



Diseases related to intermittent claudication

Symptoms for Intermittent Claudication

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Drugs & Therapeutics for Intermittent Claudication

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Drug clinical trials:

Search ClinicalTrials for Intermittent Claudication

Search NIH Clinical Center for Intermittent Claudication

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Intermittent Claudication cell therapies at LifeMap Discovery.

Genetic Tests for Intermittent Claudication

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Anatomical Context for Intermittent Claudication

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MalaCards organs/tissues related to Intermittent Claudication:

31
Testes, Endothelial, Bone, Heart, Skeletal muscle, Brain, Spinal cord

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Intermittent Claudication:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate

Animal Models for Intermittent Claudication or affiliated genes

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MGI Mouse Phenotypes related to Intermittent Claudication:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2FGF2, FGA, HTR2A, SELP
2MP:00053978.1FGF2, FGA, SELP, VWF
3MP:00053857.8VWF, SELP, FGA, FGF2

Publications for Intermittent Claudication

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Articles related to Intermittent Claudication:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Assessing the quality of available patient reported outcome measures for intermittent claudication: a systematic review using the COSMIN checklist. (25618453)
2015
2
Time-dependent effect of preinfarction angina pectoris and intermittent claudication on mortality following myocardial infarction: A Danish nationwide cohort study. (25846654)
2015
3
Effect of diabetes on the cutaneous microcirculation of the feet in patients with intermittent claudication. (25335813)
2014
4
Role of the latest endovascular technology in the treatment of intermittent claudication. (25018633)
2014
5
Modes of exercise training for intermittent claudication. (24993079)
2014
6
Vascular Reactivity Is Impaired and Associated With Walking Ability in Patients With Intermittent Claudication. (25100750)
2014
7
Exercise prescription using the heart of claudication pain onset in patients with intermittent claudication. (23917662)
2013
8
Education and home based training for intermittent claudication: functional effects and quality of life. (24177266)
2013
9
Comparison of two treadmill training programs on walking ability and endothelial function in intermittent claudication. (23117015)
2013
10
Authors' reply: systematic review of thea88efficacya88ofa88cilostazol,a88naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication (Br J Surg 2012; 99: 1630-1638). (24227373)
2013
11
Medical comorbidities but not interventions adversely affect survival in patients with intermittent claudication. (23972525)
2013
12
Free-living physical activity as a novel outcome measure in patients with intermittent claudication. (23265683)
2013
13
X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up. (23403549)
2013
14
Vasculitides as a rare cause of intermittent claudication. (23731050)
2013
15
Randomized clinical trial of a brief psychological intervention to increase walking in patients with intermittent claudication. (22038532)
2012
16
Randomized clinical trial of percutaneous transluminal angioplasty, supervised exercise and combined treatment for intermittent claudication due to femoropopliteal arterial disease. (22021102)
2012
17
Naftidrofuryl for intermittent claudication. (23235580)
2012
18
Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. (22402934)
2012
19
Validation of the Dutch version of the VascuQol questionnaire and the Amsterdam Linear Disability Score in patients with intermittent claudication. (22083223)
2012
20
Noonan syndrome presenting with neurogenic intermittent claudication. (23807040)
2012
21
Effect of supervised exercise therapy for intermittent claudication in patients with diabetes mellitus. (22858162)
2012
22
Long-term effects of structured home-based exercise program on functional capacity and quality of life in patients with intermittent claudication. (21704786)
2011
23
Quality of life and functional status after revascularization or conservative treatment in patients with intermittent claudication. (21278180)
2011
24
Gait variability of patients with intermittent claudication is similar before and after the onset of claudication pain. (21450380)
2011
25
Is remote ischemic preconditioning triggered by intermittent claudication secondary to peripheral arterial disease responsible for preventing early mortality after coronary artery bypass surgery? (21172560)
2011
26
Evaluation of patient compliance, quality of life impact and cost-effectiveness of a "test in-train out" exercise-based rehabilitation program for patients with intermittent claudication. (21712607)
2011
27
Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study. (20101352)
2010
28
Intermittent claudication as a predictor of outcome in patients with ischaemic systolic heart failure: analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure trial (CORONA). (20501489)
2010
29
Community trial of home-based exercise therapy for intermittent claudication. (19366815)
2009
30
Peripheral arterial disease and intermittent claudication: efficacy of short-term upper body strength training, dynamic exercise training, and advice to exercise at home. (20218480)
2009
31
Calf muscle hemoglobin oxygen saturation characteristics and exercise performance in patients with intermittent claudication. (18572363)
2008
32
Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. (18226561)
2008
33
Prevalence of angina, myocardial infarction and intermittent claudication assessed by Rose Questionnaire among patients with Behcet's syndrome. (18270223)
2008
34
Association between ankle-brachial index and risk factor profile in patients newly diagnosed with intermittent claudication. (18296843)
2008
35
The effects of prostaglandin E-1 in patients with intermittent claudication. (16787192)
2006
36
High-intensity interval training for intermittent claudication in a vascular rehabilitation program. (16737929)
2006
37
Intravascular ultrasound-guided creation of re-entry sites to improve intermittent claudication in patients with aortic dissection. (16784333)
2006
38
A preliminary study on the effects of exercising to maximum walking distance on platelet and endothelial function in patients with intermittent claudication. (16360327)
2006
39
Walking exercise in patients with intermittent claudication not well implemented in Dutch primary care. (15841062)
2005
40
Rapid foot and calf compression increases walking distance in patients with intermittent claudication: results of a randomized study. (15886663)
2005
41
Management options for patients with intermittent claudication. (15150459)
2004
42
Natural history of stenosis in the iliac arteries in patients with intermittent claudication undergoing clinical treatment. (15654487)
2004
43
Bilateral intermittent claudication and the aorta. (15042397)
2004
44
Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model. (12907137)
2003
45
Efficacy and safety of cilostazol, a novel phosphodiesterase inhibitor in patients with intermittent claudication. (15168999)
2003
46
Platelets' glycoproteins and their ligands in patients with intermittent claudication. (12865882)
2003
47
Management of intermittent claudication (Br J Surg 2002; 89: 529-31). (12296906)
2002
48
Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication. (11782701)
2001
49
Serum lipoproteins and hemostatic function in intermittent claudication. (8399080)
1993
50
Efficacy of low-molecular-weight heparin in the management of intermittent claudication. (1847026)
1991

Variations for Intermittent Claudication

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Expression for genes affiliated with Intermittent Claudication

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Search GEO for disease gene expression data for Intermittent Claudication.

Pathways for genes affiliated with Intermittent Claudication

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Compounds for genes affiliated with Intermittent Claudication

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Compounds related to Intermittent Claudication according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1sarpogrelate hydrochloride4410.0HTR2A, SELP
2sarpogrelate28 4411.0HTR2A, SELP
3fucoidan449.8FGF2, SELP
4tetramethylpyrazine449.8VWF, SELP
5echistatin449.8SELP, VWF
6hydroxyethyl starch449.8SELP, VWF
7quinapril44 50 1111.8VWF, SELP
8tirofiban44 1110.8VWF, SELP
9ristocetin449.7VWF, SELP
10abciximab44 1110.7SELP, VWF
11batroxobin449.6SELP, FGA
12iohexol449.6FGA, SELP
13desmopressin44 60 28 1112.6SELP, VWF
14bivalirudin44 1110.6FGA, SELP
15yohimbine44 1 28 1112.6VWF, HTR2A
16argatroban44 1110.6SELP, FGA
17clopidogrel44 50 24 1112.6SELP, VWF
18ptca449.5FGA, SELP
19cuprophan449.5FGA, SELP
20sucralfate44 1110.5FGF2, FGA
21kininogen449.4VWF, SELP
22sodium chlorate449.4FGF2, SELP, VWF
236-ketoprostaglandin f1alpha449.4FGA, VWF
24dermatan sulfate449.3SELP, FGF2, VWF
25citrate449.3SELP, VWF, FGF2
26carbohydrates449.3SELP, FGF2, VWF
27amiloride44 28 1111.2SELP, FGF2
28protamine449.1FGA, SELP, FGF2
2911-dehydrothromboxane b2449.1VWF, SELP, FGA
30ppack449.1SELP, VWF, FGA
31ticlopidine44 1110.1SELP, VWF, FGA
32polysulfone449.1VWF, SELP, FGA
33hirudin449.1SELP, FGA, VWF
34txb2449.1VWF, SELP, FGA
35thromboxane44 2410.0VWF, SELP, FGA
36cyclosporin a44 28 6011.0SELP, FGF2, VWF
37thromboxane a244 2410.0SELP, VWF, FGA
38aprotinin44 1110.0FGA, SELP, VWF
39aspirin44 50 28 2412.0FGA, SELP, VWF
40epinephrine44 24 1110.9FGA, VWF, SELP
41fibrinogen448.9VWF, SELP, FGA
42histamine44 28 2410.9FGA, SELP, VWF
43pge2448.8FGF2, SELP, FGA
44lactate448.6VWF, FGA, SELP
45norepinephrine44 24 1110.6FGA, HTR2A, SELP, VWF
46dipyridamole44 60 28 1111.6FGA, FGF2, SELP, VWF
47warfarin44 50 24 1111.6SELP, FGF2, FGA, VWF
48prostacyclin448.5SELP, VWF, FGA, FGF2
49creatinine448.5FGA, SELP, VWF
50heparin44 28 24 1111.5SELP, FGF2, FGA, VWF

GO Terms for genes affiliated with Intermittent Claudication

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Cellular components related to Intermittent Claudication according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.0FGA, VWF
2platelet alpha granuleGO:00310918.9FGA, VWF
3external side of plasma membraneGO:00098978.3FGA, SELP, VWF

Biological processes related to Intermittent Claudication according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1release of sequestered calcium ion into cytosolGO:00512099.5FGF2, HTR2A
2positive regulation of ERK1 and ERK2 cascadeGO:00703749.5FGF2, HTR2A
3platelet degranulationGO:00025768.7FGA, SELP, VWF
4platelet activationGO:00301688.7FGA, SELP, VWF
5extracellular matrix organizationGO:00301988.4VWF, FGA, FGF2
6blood coagulationGO:00075968.3FGA, SELP, VWF

Molecular functions related to Intermittent Claudication according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.5FGF2, SELP
2glycoprotein bindingGO:00019489.3SELP, VWF
3protein N-terminus bindingGO:00474859.0PEX19, VWF

Sources for Intermittent Claudication

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet