MCID: INT002
MIFTS: 55

Intermittent Claudication malady

Cardiovascular diseases category
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Summaries for Intermittent Claudication

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Wikipedia:65 Intermittent claudication (Latin: claudicatio intermittens) is a clinical diagnosis given for muscle... more...

MalaCards based summary: Intermittent Claudication, also known as intermittent claudication nos, is related to peripheral vascular disease and ischemia. An important gene associated with Intermittent Claudication is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Cell adhesion Plasmin signaling and Complement and coagulation cascades. The drugs pentoxifylline and cilostazol and the compounds sarpogrelate hydrochloride and sarpogrelate have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and bone, and related mouse phenotypes are skeleton and hematopoietic system.

Aliases & Classifications for Intermittent Claudication

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Intermittent Claudication, Aliases & Descriptions:

Name: Intermittent Claudication 30 8 10 44 62
Intermittent Claudication Nos 8
 
Charcot's Syndrome 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:3669
MeSH34 D007383

Related Diseases for Intermittent Claudication

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Diseases related to Intermittent Claudication via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease30.7VWF, SELP
2ischemia30.5SELP, FGA, FGF2
3vascular disease30.3VWF, SELP, FGF2
4diabetes mellitus30.1FGA, SELP, VWF
5atherosclerosis30.0FGF2, FGA, SELP, VWF
6myocardial infarction29.9VWF, SELP, HTR2A, FGA
7artery disease10.9
8peripheral artery disease10.9
9endotheliitis10.7
10blindness10.6
11spinal stenosis10.6
12limb ischemia10.5
13cystic adventitial disease10.5
14critical limb ischemia10.5
15arteriosclerosis10.4
16aneurysm10.4
17coronary thrombosis10.3VWF
18hypertension10.3
19abdominal aortic aneurysm10.3
20arteriosclerosis obliterans10.3
21aortic aneurysm10.3
22fibromuscular dysplasia10.3
23blood platelet disease10.2VWF, SELP
24von willebrand's disease10.2SELP, VWF
25factor viii deficiency10.1VWF, SELP
26thrombotic thrombocytopenic purpura, acquired10.1VWF, SELP
27angina pectoris10.1
28arteriovenous fistula10.1
29obesity10.1
30pseudoxanthoma elasticum10.1
31spondylosis10.1
32carotid stenosis10.1
33systolic heart failure10.1
34neuronitis10.1
35noonan syndrome10.1
36amyloidosis10.1
37carotid artery disease10.1
38cervicitis10.1
39compartment syndrome10.1
40lipoma10.1
41lymphangioma10.1
42neurofibroma10.1
43pneumonia10.1
44proteinuria10.1
45hypoxia10.1
46insulin resistance10.1
47hemorrhagic thrombocythemia10.1SELP, VWF
48mitral valve stenosis10.1SELP, FGA
49antiphospholipid syndrome10.1VWF, SELP
50proliferative diabetic retinopathy10.1FGF2, SELP

Graphical network of the top 20 diseases related to Intermittent Claudication:



Diseases related to intermittent claudication

Symptoms for Intermittent Claudication

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Drugs & Therapeutics for Intermittent Claudication

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Drug clinical trials:

Search ClinicalTrials for Intermittent Claudication

Search NIH Clinical Center for Intermittent Claudication

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intermittent Claudication cell therapies at LifeMap Discovery.

Genetic Tests for Intermittent Claudication

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Anatomical Context for Intermittent Claudication

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MalaCards organs/tissues related to Intermittent Claudication:

32
Testes, Endothelial, Bone, Heart, Skeletal muscle, Brain, Spinal cord

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Intermittent Claudication:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate

Animal Models for Intermittent Claudication or affiliated genes

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MGI Mouse Phenotypes related to Intermittent Claudication:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2FGF2, FGA, HTR2A, SELP
2MP:00053978.1FGF2, FGA, SELP, VWF
3MP:00053857.8VWF, SELP, FGA, FGF2

Publications for Intermittent Claudication

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Articles related to Intermittent Claudication:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Effect of diabetes on the cutaneous microcirculation of the feet in patients with intermittent claudication. (25335813)
2014
2
Role of the latest endovascular technology in the treatment of intermittent claudication. (25018633)
2014
3
Modes of exercise training for intermittent claudication. (24993079)
2014
4
Vascular Reactivity Is Impaired and Associated With Walking Ability in Patients With Intermittent Claudication. (25100750)
2014
5
Exercise prescription using the heart of claudication pain onset in patients with intermittent claudication. (23917662)
2013
6
Education and home based training for intermittent claudication: functional effects and quality of life. (24177266)
2013
7
Comparison of two treadmill training programs on walking ability and endothelial function in intermittent claudication. (23117015)
2013
8
Authors' reply: systematic review of thea88efficacya88ofa88cilostazol,a88naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication (Br J Surg 2012; 99: 1630-1638). (24227373)
2013
9
Medical comorbidities but not interventions adversely affect survival in patients with intermittent claudication. (23972525)
2013
10
Free-living physical activity as a novel outcome measure in patients with intermittent claudication. (23265683)
2013
11
X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up. (23403549)
2013
12
Vasculitides as a rare cause of intermittent claudication. (23731050)
2013
13
Randomized clinical trial of a brief psychological intervention to increase walking in patients with intermittent claudication. (22038532)
2012
14
Randomized clinical trial of percutaneous transluminal angioplasty, supervised exercise and combined treatment for intermittent claudication due to femoropopliteal arterial disease. (22021102)
2012
15
Naftidrofuryl for intermittent claudication. (23235580)
2012
16
Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. (22402934)
2012
17
Validation of the Dutch version of the VascuQol questionnaire and the Amsterdam Linear Disability Score in patients with intermittent claudication. (22083223)
2012
18
Noonan syndrome presenting with neurogenic intermittent claudication. (23807040)
2012
19
Effect of supervised exercise therapy for intermittent claudication in patients with diabetes mellitus. (22858162)
2012
20
Long-term effects of structured home-based exercise program on functional capacity and quality of life in patients with intermittent claudication. (21704786)
2011
21
Quality of life and functional status after revascularization or conservative treatment in patients with intermittent claudication. (21278180)
2011
22
Gait variability of patients with intermittent claudication is similar before and after the onset of claudication pain. (21450380)
2011
23
Is remote ischemic preconditioning triggered by intermittent claudication secondary to peripheral arterial disease responsible for preventing early mortality after coronary artery bypass surgery? (21172560)
2011
24
Evaluation of patient compliance, quality of life impact and cost-effectiveness of a "test in-train out" exercise-based rehabilitation program for patients with intermittent claudication. (21712607)
2011
25
Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study. (20101352)
2010
26
Intermittent claudication as a predictor of outcome in patients with ischaemic systolic heart failure: analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure trial (CORONA). (20501489)
2010
27
Community trial of home-based exercise therapy for intermittent claudication. (19366815)
2009
28
Peripheral arterial disease and intermittent claudication: efficacy of short-term upper body strength training, dynamic exercise training, and advice to exercise at home. (20218480)
2009
29
Calf muscle hemoglobin oxygen saturation characteristics and exercise performance in patients with intermittent claudication. (18572363)
2008
30
Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. (18226561)
2008
31
Prevalence of angina, myocardial infarction and intermittent claudication assessed by Rose Questionnaire among patients with Behcet's syndrome. (18270223)
2008
32
Association between ankle-brachial index and risk factor profile in patients newly diagnosed with intermittent claudication. (18296843)
2008
33
Cardiac risk reduction in patients with intermittent claudication. (17400485)
2007
34
The effects of prostaglandin E-1 in patients with intermittent claudication. (16787192)
2006
35
High-intensity interval training for intermittent claudication in a vascular rehabilitation program. (16737929)
2006
36
Intravascular ultrasound-guided creation of re-entry sites to improve intermittent claudication in patients with aortic dissection. (16784333)
2006
37
A preliminary study on the effects of exercising to maximum walking distance on platelet and endothelial function in patients with intermittent claudication. (16360327)
2006
38
Intermittent claudication. (17095782)
2006
39
Walking exercise in patients with intermittent claudication not well implemented in Dutch primary care. (15841062)
2005
40
Rapid foot and calf compression increases walking distance in patients with intermittent claudication: results of a randomized study. (15886663)
2005
41
Management options for patients with intermittent claudication. (15150459)
2004
42
Natural history of stenosis in the iliac arteries in patients with intermittent claudication undergoing clinical treatment. (15654487)
2004
43
Bilateral intermittent claudication and the aorta. (15042397)
2004
44
Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model. (12907137)
2003
45
Efficacy and safety of cilostazol, a novel phosphodiesterase inhibitor in patients with intermittent claudication. (15168999)
2003
46
Platelets' glycoproteins and their ligands in patients with intermittent claudication. (12865882)
2003
47
Management of intermittent claudication (Br J Surg 2002; 89: 529-31). (12296906)
2002
48
Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication. (11782701)
2001
49
Serum lipoproteins and hemostatic function in intermittent claudication. (8399080)
1993
50
Efficacy of low-molecular-weight heparin in the management of intermittent claudication. (1847026)
1991

Variations for Intermittent Claudication

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Expression for genes affiliated with Intermittent Claudication

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Expression patterns in normal tissues for genes affiliated with Intermittent Claudication

Search GEO for disease gene expression data for Intermittent Claudication.

Pathways for genes affiliated with Intermittent Claudication

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Compounds for genes affiliated with Intermittent Claudication

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Compounds related to Intermittent Claudication according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1sarpogrelate hydrochloride4410.0HTR2A, SELP
2sarpogrelate28 4411.0HTR2A, SELP
3tetramethylpyrazine449.8SELP, VWF
4fucoidan449.8SELP, FGF2
5echistatin449.8VWF, SELP
6hydroxyethyl starch449.8SELP, VWF
7quinapril44 50 1111.8VWF, SELP
8tirofiban44 1110.8VWF, SELP
9ristocetin449.7SELP, VWF
10abciximab44 1110.7SELP, VWF
11batroxobin449.6FGA, SELP
12desmopressin44 61 28 1112.6SELP, VWF
13iohexol449.6SELP, FGA
14bivalirudin44 1110.6SELP, FGA
15argatroban44 1110.6FGA, SELP
16yohimbine44 2 28 1112.6HTR2A, VWF
17clopidogrel44 50 24 1112.6VWF, SELP
18ptca449.5SELP, FGA
19cuprophan449.5FGA, SELP
20sucralfate44 1110.5FGA, FGF2
21kininogen449.4SELP, VWF
22sodium chlorate449.4FGF2, SELP, VWF
236-ketoprostaglandin f1alpha449.4FGA, VWF
24dermatan sulfate449.3VWF, SELP, FGF2
25citrate449.3VWF, SELP, FGF2
26carbohydrates449.3FGF2, SELP, VWF
27amiloride44 28 1111.2FGF2, SELP
28protamine449.1FGF2, FGA, SELP
2911-dehydrothromboxane b2449.1FGA, SELP, VWF
30ppack449.1VWF, SELP, FGA
31ticlopidine44 1110.1FGA, SELP, VWF
32polysulfone449.1FGA, SELP, VWF
33hirudin449.1FGA, SELP, VWF
34txb2449.1VWF, SELP, FGA
35thromboxane44 2410.0FGA, SELP, VWF
36cyclosporin a44 28 6111.0FGF2, SELP, VWF
37thromboxane a244 2410.0VWF, SELP, FGA
38aprotinin44 1110.0FGA, SELP, VWF
39aspirin44 50 28 2412.0FGA, SELP, VWF
40epinephrine44 24 1110.9FGA, SELP, VWF
41fibrinogen448.9FGA, SELP, VWF
42histamine44 28 2410.9VWF, SELP, FGA
43pge2448.8FGF2, FGA, SELP
44lactate448.6VWF, SELP, FGA
45norepinephrine44 24 1110.6FGA, HTR2A, SELP, VWF
46dipyridamole44 61 28 1111.6FGF2, FGA, SELP, VWF
47warfarin44 50 24 1111.6VWF, SELP, FGA, FGF2
48prostacyclin448.5VWF, SELP, FGA, FGF2
49creatinine448.5FGA, SELP, VWF
50heparin44 28 24 1111.5VWF, SELP, FGA, FGF2

GO Terms for genes affiliated with Intermittent Claudication

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Cellular components related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0FGA, VWF
2platelet alpha granuleGO:0310918.9FGA, VWF
3external side of plasma membraneGO:0098978.3FGA, SELP, VWF

Biological processes related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1release of sequestered calcium ion into cytosolGO:0512099.5FGF2, HTR2A
2positive regulation of ERK1 and ERK2 cascadeGO:0703749.5FGF2, HTR2A
3platelet degranulationGO:0025768.7FGA, SELP, VWF
4platelet activationGO:0301688.7FGA, SELP, VWF
5extracellular matrix organizationGO:0301988.4VWF, FGA, FGF2
6blood coagulationGO:0075968.3FGA, SELP, VWF

Molecular functions related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.5FGF2, SELP
2glycoprotein bindingGO:0019489.3SELP, VWF
3protein N-terminus bindingGO:0474859.0PEX19, VWF

Products for genes affiliated with Intermittent Claudication

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  • Antibodies
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Sources for Intermittent Claudication

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet