MCID: INT002
MIFTS: 55

Intermittent Claudication malady

Cardiovascular diseases category
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Summaries for Intermittent Claudication

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65Wikipedia, 33MalaCards
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Wikipedia:65 Intermittent claudication (Latin: claudicatio intermittens) is a clinical diagnosis given for muscle... more...

MalaCards: Intermittent Claudication, also known as intermittent claudication nos, is related to ischemia and atherosclerosis. An important gene associated with Intermittent Claudication is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Cell adhesion Plasmin signaling and Complement and coagulation cascades. The drugs pentoxifylline and cilostazol and the compounds sarpogrelate hydrochloride and sarpogrelate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and testes, and related mouse phenotypes are skeleton and hematopoietic system.

Aliases & Classifications for Intermittent Claudication

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8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

intermittent claudication 8 10 45 31 62
intermittent claudication nos 8
charcot's syndrome 8


External Ids:

Disease Ontology8 DOID:3669
MeSH35 D007383

Related Diseases for Intermittent Claudication

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intermittent Claudication via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.7SELP, FGA, FGF2
2atherosclerosis30.5SELP, FGA, VWF, FGF2
3peripheral vascular disease30.4VWF, SELP
4diabetes mellitus30.4FGA, VWF, SELP
5vascular disease30.4SELP, VWF, FGF2
6myocardial infarction30.3FGA, HTR2A, SELP, VWF
7coronary artery disease30.1FGA, SELP
8artery disease10.9
9peripheral artery disease10.9
10blindness10.6
11endotheliitis10.6
12spinal stenosis10.6
13limb ischemia10.5
14critical limb ischemia10.5
15cystic adventitial disease10.5
16arteriosclerosis10.4
17aneurysm10.4
18arteriosclerosis obliterans10.3
19abdominal aortic aneurysm10.3
20aortic aneurysm10.3
21hypertension10.3
22fibromuscular dysplasia10.3
23angina pectoris10.1
24arteriovenous fistula10.1
25pseudoxanthoma elasticum10.1
26spondylosis10.1
27neuronitis10.1
28systolic heart failure10.1
29noonan syndrome10.1
30carotid stenosis10.1
31amyloidosis10.1
32carotid artery disease10.1
33cervicitis10.1
34compartment syndrome10.1
35lipoma10.1
36lymphangioma10.1
37neurofibroma10.1
38obesity10.1
39pneumonia10.1
40proteinuria10.1
41hypoxia10.1
42insulin resistance10.1
43coronary thrombosis10.1VWF
44blood platelet disease10.0SELP, VWF
45von willebrand's disease10.0VWF, SELP
46factor viii deficiency10.0VWF, SELP
47thrombotic thrombocytopenic purpura, acquired10.0SELP, VWF
48hemorrhagic thrombocythemia10.0VWF, SELP
49mitral valve stenosis10.0FGA, SELP
50antiphospholipid syndrome10.0VWF, SELP

Graphical network of the top 20 diseases related to Intermittent Claudication:



Diseases related to intermittent claudication

Symptoms for Intermittent Claudication

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Drugs & Therapeutics for Intermittent Claudication

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Intermittent Claudication

Search NIH Clinical Center for Intermittent Claudication

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intermittent Claudication cell therapies at LifeMap Discovery.

Genetic Tests for Intermittent Claudication

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Anatomical Context for Intermittent Claudication

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Intermittent Claudication:

33
Endothelial, Bone, Testes, Heart, Skeletal muscle, Brain, Spinal cord

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Intermittent Claudication:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate

Animal Models for Intermittent Claudication or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Intermittent Claudication:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2FGF2, FGA, HTR2A, SELP
2MP:00053978.1FGF2, FGA, SELP, VWF
3MP:00053857.8VWF, SELP, FGA, FGF2

Publications for Intermittent Claudication

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Sources:
52PubMed
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Articles related to Intermittent Claudication:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Exercise prescription using the heart of claudication pain onset in patients with intermittent claudication. (23917662)
2013
2
Education and home based training for intermittent claudication: functional effects and quality of life. (24177266)
2013
3
Comparison of two treadmill training programs on walking ability and endothelial function in intermittent claudication. (23117015)
2013
4
Authors' reply: systematic review of thea88efficacya88ofa88cilostazol,a88naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication (Br J Surg 2012; 99: 1630-1638). (24227373)
2013
5
Medical comorbidities but not interventions adversely affect survival in patients with intermittent claudication. (23972525)
2013
6
Free-living physical activity as a novel outcome measure in patients with intermittent claudication. (23265683)
2013
7
X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up. (23403549)
2013
8
Vasculitides as a rare cause of intermittent claudication. (23731050)
2013
9
Randomized clinical trial of a brief psychological intervention to increase walking in patients with intermittent claudication. (22038532)
2012
10
Randomized clinical trial of percutaneous transluminal angioplasty, supervised exercise and combined treatment for intermittent claudication due to femoropopliteal arterial disease. (22021102)
2012
11
Naftidrofuryl for intermittent claudication. (23235580)
2012
12
Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. (22402934)
2012
13
Validation of the Dutch version of the VascuQol questionnaire and the Amsterdam Linear Disability Score in patients with intermittent claudication. (22083223)
2012
14
Noonan syndrome presenting with neurogenic intermittent claudication. (23807040)
2012
15
Effect of supervised exercise therapy for intermittent claudication in patients with diabetes mellitus. (22858162)
2012
16
Long-term effects of structured home-based exercise program on functional capacity and quality of life in patients with intermittent claudication. (21704786)
2011
17
Quality of life and functional status after revascularization or conservative treatment in patients with intermittent claudication. (21278180)
2011
18
Gait variability of patients with intermittent claudication is similar before and after the onset of claudication pain. (21450380)
2011
19
Is remote ischemic preconditioning triggered by intermittent claudication secondary to peripheral arterial disease responsible for preventing early mortality after coronary artery bypass surgery? (21172560)
2011
20
Evaluation of patient compliance, quality of life impact and cost-effectiveness of a "test in-train out" exercise-based rehabilitation program for patients with intermittent claudication. (21712607)
2011
21
Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study. (20101352)
2010
22
Intermittent claudication as a predictor of outcome in patients with ischaemic systolic heart failure: analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure trial (CORONA). (20501489)
2010
23
Community trial of home-based exercise therapy for intermittent claudication. (19366815)
2009
24
Peripheral arterial disease and intermittent claudication: efficacy of short-term upper body strength training, dynamic exercise training, and advice to exercise at home. (20218480)
2009
25
Calf muscle hemoglobin oxygen saturation characteristics and exercise performance in patients with intermittent claudication. (18572363)
2008
26
Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. (18226561)
2008
27
Prevalence of angina, myocardial infarction and intermittent claudication assessed by Rose Questionnaire among patients with Behcet's syndrome. (18270223)
2008
28
Association between ankle-brachial index and risk factor profile in patients newly diagnosed with intermittent claudication. (18296843)
2008
29
Cardiac risk reduction in patients with intermittent claudication. (17400485)
2007
30
AJR Teaching File: intermittent claudication of the lower extremity in a young patient. (17715070)
2007
31
The effects of prostaglandin E-1 in patients with intermittent claudication. (16787192)
2006
32
High-intensity interval training for intermittent claudication in a vascular rehabilitation program. (16737929)
2006
33
Intravascular ultrasound-guided creation of re-entry sites to improve intermittent claudication in patients with aortic dissection. (16784333)
2006
34
A preliminary study on the effects of exercising to maximum walking distance on platelet and endothelial function in patients with intermittent claudication. (16360327)
2006
35
Intermittent claudication. (17095782)
2006
36
Walking exercise in patients with intermittent claudication not well implemented in Dutch primary care. (15841062)
2005
37
Rapid foot and calf compression increases walking distance in patients with intermittent claudication: results of a randomized study. (15886663)
2005
38
Assessment of disease impact in patients with intermittent claudication: discrepancy between health status and quality of life. (15838478)
2005
39
Management options for patients with intermittent claudication. (15150459)
2004
40
Natural history of stenosis in the iliac arteries in patients with intermittent claudication undergoing clinical treatment. (15654487)
2004
41
Bilateral intermittent claudication and the aorta. (15042397)
2004
42
Omega-3 fatty acids for intermittent claudication. (15266504)
2004
43
Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model. (12907137)
2003
44
Efficacy and safety of cilostazol, a novel phosphodiesterase inhibitor in patients with intermittent claudication. (15168999)
2003
45
Platelets' glycoproteins and their ligands in patients with intermittent claudication. (12865882)
2003
46
Effects of simvastatin on walking performance and symptoms of intermittent claudication in hypercholesterolemic patients with peripheral vascular disease. (12714124)
2003
47
Management of intermittent claudication (Br J Surg 2002; 89: 529-31). (12296906)
2002
48
Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication. (11782701)
2001
49
Serum lipoproteins and hemostatic function in intermittent claudication. (8399080)
1993
50
Efficacy of low-molecular-weight heparin in the management of intermittent claudication. (1847026)
1991

Variations for Intermittent Claudication

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Expression for genes affiliated with Intermittent Claudication

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Claudication

Search GEO for disease gene expression data for Intermittent Claudication.

Pathways for genes affiliated with Intermittent Claudication

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Sources:
50PathCards, 60Thomson Reuters, 30KEGG, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 53QIAGEN, 54R&D Systems
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Compounds for genes affiliated with Intermittent Claudication

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Intermittent Claudication according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1sarpogrelate hydrochloride4510.0HTR2A, SELP
2sarpogrelate29 4511.0HTR2A, SELP
3fucoidan459.8FGF2, SELP
4tetramethylpyrazine459.8VWF, SELP
5echistatin459.8SELP, VWF
6hydroxyethyl starch459.8SELP, VWF
7quinapril45 51 1111.8VWF, SELP
8tirofiban45 1110.8VWF, SELP
9ristocetin459.7VWF, SELP
10abciximab45 1110.7SELP, VWF
11batroxobin459.6SELP, FGA
12iohexol459.6FGA, SELP
13desmopressin45 61 29 1112.6SELP, VWF
14bivalirudin45 1110.6FGA, SELP
15yohimbine45 3 29 1112.6VWF, HTR2A
16argatroban45 1110.6SELP, FGA
17clopidogrel45 51 24 1112.6SELP, VWF
18ptca459.5FGA, SELP
19cuprophan459.5FGA, SELP
20sucralfate45 1110.5FGF2, FGA
21kininogen459.4VWF, SELP
22sodium chlorate459.4FGF2, SELP, VWF
236-ketoprostaglandin f1alpha459.4FGA, VWF
24dermatan sulfate459.3SELP, FGF2, VWF
25citrate459.3SELP, VWF, FGF2
26carbohydrates459.3SELP, FGF2, VWF
27amiloride45 29 1111.2SELP, FGF2
28protamine459.1FGA, SELP, FGF2
2911-dehydrothromboxane b2459.1VWF, SELP, FGA
30ppack459.1SELP, VWF, FGA
31ticlopidine45 1110.1SELP, VWF, FGA
32polysulfone459.1VWF, SELP, FGA
33hirudin459.1SELP, FGA, VWF
34txb2459.1VWF, SELP, FGA
35thromboxane45 2410.0VWF, SELP, FGA
36cyclosporin a45 29 6111.0SELP, FGF2, VWF
37thromboxane a245 2410.0SELP, VWF, FGA
38aprotinin45 1110.0FGA, SELP, VWF
39aspirin45 51 29 2412.0FGA, SELP, VWF
40epinephrine45 24 1110.9FGA, VWF, SELP
41fibrinogen458.9VWF, SELP, FGA
42histamine45 29 2410.9FGA, SELP, VWF
43pge2458.8FGF2, SELP, FGA
44lactate458.6VWF, FGA, SELP
45norepinephrine45 24 1110.6FGA, HTR2A, SELP, VWF
46dipyridamole45 61 29 1111.6FGA, FGF2, SELP, VWF
47warfarin45 51 24 1111.6SELP, FGF2, FGA, VWF
48prostacyclin458.5SELP, VWF, FGA, FGF2
49creatinine458.5FGA, SELP, VWF
50heparin45 29 24 1111.5SELP, FGF2, FGA, VWF

GO Terms for genes affiliated with Intermittent Claudication

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16Gene Ontology
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Cellular components related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0FGA, VWF
2platelet alpha granuleGO:0310918.9FGA, VWF
3external side of plasma membraneGO:0098978.3FGA, SELP, VWF

Biological processes related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1release of sequestered calcium ion into cytosolGO:0512099.5HTR2A, FGF2
2positive regulation of ERK1 and ERK2 cascadeGO:0703749.5FGF2, HTR2A
3platelet degranulationGO:0025768.7FGA, SELP, VWF
4platelet activationGO:0301688.7VWF, SELP, FGA
5extracellular matrix organizationGO:0301988.4VWF, FGF2, FGA
6blood coagulationGO:0075968.3VWF, FGA, SELP

Molecular functions related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.5FGF2, SELP
2glycoprotein bindingGO:0019489.3SELP, VWF
3protein N-terminus bindingGO:0474859.0PEX19, VWF

Products for genes affiliated with Intermittent Claudication

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermittent Claudication

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet