MCID: INT002
MIFTS: 56

Intermittent Claudication malady

Summaries for Intermittent Claudication

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intermittent claudication (Latin: claudicatio intermittens) is a clinical diagnosis given for muscle... more...

MalaCards: Intermittent Claudication, also known as intermittent claudication nos, is related to ischemia and peripheral vascular disease. An important gene associated with Intermittent Claudication is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are GRB2:SOS provides linkage to MAPK signaling for Intergrins and FGFR1b ligand binding and activation. The drugs pentoxifylline and cilostazol and the compounds pge2 and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and testes, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Intermittent Claudication

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

intermittent claudication 8 10 44 30 60
intermittent claudication nos 8
charcot's syndrome 8


External Ids:

Disease Ontology8 DOID:3669
MeSH34 D007383

Related Diseases for Intermittent Claudication

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17GeneCards, 18GeneDecks
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Diseases related to Intermittent Claudication via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.8KCNJ5, PF4, FGF1, FGA, FGF2, PGF
2peripheral vascular disease30.7VWF, THBD, SELP
3vascular disease30.7HTR2A, PPBP, FGA, FGF2, VWF, THBD
4atherosclerosis30.5PF4, PPBP, SAA4, LSS, FGF1, FGA
5arteriosclerosis30.4FGF1
6diabetes mellitus30.4KCNJ5, CALCA, PF4, FGA, VWF, THBD
7arteriosclerosis obliterans30.3SELP, PF4
8stroke, ischemic30.3PPBP
9hypertension30.3PGF, PPBP, CALCA
10myocardial infarction30.3FGF1, FGA, PGF, VWF, SELP, PF4
11coronary artery disease30.3PGF, VWF, THBD, SELP, FGA, FGF1
12obesity30.1KCNJ5, SAA4, HTR2A
13proteinuria30.1SAA4, PF4, FGA, PGF
14pneumonia30.1FGA, SAA4
15spinal stenosis10.6
16critical limb ischemia10.4
17abdominal aortic aneurysm10.3
18aortic aneurysm10.3
19angina pectoris10.1
20arteriovenous fistula10.1
21carotid stenosis10.1
22pseudoxanthoma elasticum10.1
23noonan syndrome10.1
24spondylosis10.1
25neuronitis10.1
26systolic heart failure10.1
27cauda equina syndrome10.1
28amyloidosis10.1
29aortic disease10.1
30brain disease10.1
31carotid artery disease10.1
32cervicitis10.1
33compartment syndrome10.1
34lipoma10.1
35lymphangioma10.1
36neurofibroma10.1
37pancreatitis10.0SELP
38peritonitis10.0SELP
39hemangioma10.0FGF2
40psoriasis10.0SELP
41hepatitis10.0UGT1A1
42cystic fibrosis10.0HTR2A
43eclampsia10.0THBD
44cerebrovascular disease10.0SELP
45sarcoma10.0PGF
46leiomyoma10.0FGF1
47acute leukemia10.0FGA
48polycythemia10.0PPBP
49thyroiditis10.0CALCA
50dermatitis10.0PF4

Graphical network of the top 20 diseases related to Intermittent Claudication:



Diseases related to intermittent claudication

Clinical Features for Intermittent Claudication

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Drugs & Therapeutics for Intermittent Claudication

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intermittent Claudication

Drug clinical trials:

Search ClinicalTrials for Intermittent Claudication

Search NIH Clinical Center for Intermittent Claudication

Search CenterWatch for Intermittent Claudication

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intermittent Claudication cell therapies at LifeMap Discovery.

Genetic Tests for Intermittent Claudication

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Anatomical Context for Intermittent Claudication

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Intermittent Claudication:

32
Endothelial, Bone, Testes, Heart, Skeletal muscle, Brain, Spinal cord, Skin

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Intermittent Claudication:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate

Animal Models for Intermittent Claudication or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intermittent Claudication:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.8SELP, PGF, FGA, CALCA, KCNJ5

Publications for Intermittent Claudication

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50PubMed
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Articles related to Intermittent Claudication:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Omega-3 fatty acids for intermittent claudication. (23824785)
2013
2
Endovascular Treatment for Intermittent Claudication in Patients with Peripheral Arterial Disease: A Systematic Review. (24342830)
2013
3
Twelve-months follow-up of supervised exercise after percutaneous transluminal angioplasty for intermittent claudication: a randomised clinical trial. (24284358)
2013
4
Systematic review of home-based exercise programmes for individuals with intermittent claudication. (24076079)
2013
5
Prostanoids for intermittent claudication. (23633305)
2013
6
Supervised walking training improves maximum and pain-free walking distances in people with intermittent claudication. (23570696)
2013
7
Re: Interspinous spacers versus decompressive surgery for lumbar neurogenic intermittent claudication. Spine 2013;38:1525. (23900116)
2013
8
Treatment of facet cysts associated with neurogenic intermittent claudication with x-stop. (22134735)
2013
9
Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. (24378378)
2013
10
Exercise for intermittent claudication and peripheral arterial disease. (24324991)
2013
11
Randomized clinical trial of a brief psychological intervention to increase walking in patients with intermittent claudication. (22038532)
2012
12
Effect of supervised exercise therapy for intermittent claudication in patients with diabetes mellitus. (22858162)
2012
13
Incidence and treatment of local stenosis or occlusion at the vascular access site leading to limb ischemia and new-onset intermittent claudication after percutaneous interventions: implications of vascular closure devices. (21542117)
2012
14
Study on differentiation factors for main disease identification of intermittent claudication. (23366976)
2012
15
MRI of arterial flow reserve in patients with intermittent claudication: feasibility and initial experience. (22412836)
2012
16
Extracorporeal shock wave therapy improves the walking ability of patients with peripheral artery disease and intermittent claudication. (22447002)
2012
17
Supervised exercise therapy for intermittent claudication: current status and future perspectives. (22328620)
2012
18
Use of a three-curved rocker sole shoe modification to improve intermittent claudication calf pain--a pilot study. (22321402)
2012
19
Gait variability of patients with intermittent claudication is similar before and after the onset of claudication pain. (21450380)
2011
20
Is remote ischemic preconditioning triggered by intermittent claudication secondary to peripheral arterial disease responsible for preventing early mortality after coronary artery bypass surgery? (21172560)
2011
21
Antiplatelet agents for intermittent claudication. (22071801)
2011
22
Phosphodiesterases as targets for intermittent claudication. (21695642)
2011
23
What is the place of surgery for intermittent claudication? (20359912)
2010
24
Increasing walking in patients with intermittent claudication: protocol for a randomised controlled trial. (20929555)
2010
25
Multicenter randomized clinical trial of supervised exercise therapy with or without feedback versus walking advice for intermittent claudication. (20478681)
2010
26
Ergometric performance during exercise training in men with intermittent claudication. (20630439)
2010
27
Efficacy of cilostazol after endovascular therapy for femoropopliteal artery disease in patients with intermittent claudication. (19118724)
2009
28
Intermittent pneumatic compression in stable claudicants: effect on hemostasis and endothelial function. (19935591)
2009
29
Pain threshold is achieved at intensity above anaerobic threshold in patients with intermittent claudication. (19770807)
2009
30
Effect of ramipril on renal function in patients with intermittent claudication. (18561523)
2008
31
Supervised and home-based exercise training for patients with intermittent claudication. (22477417)
2008
32
Intermittent claudication in the Erfurt Male Cohort (ERFORT) Study: its determinants and the impact on mortality. A population-based prospective cohort study with 30 years of follow-up. (17950299)
2008
33
Measurement of ischaemia-reperfusion in patients with intermittent claudication using NMR-based metabonomics. (18246538)
2008
34
Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication. (19374074)
2008
35
Cardiac risk reduction in patients with intermittent claudication. (17400485)
2007
36
Effect of the oral hypoglycaemic sulphonylurea glibenclamide, a blocker of ATP-sensitive potassium channels, on walking distance in patients with intermittent claudication. (16492219)
2006
37
Insertion loads of the X STOP interspinous process distraction system designed to treat neurogenic intermittent claudication. (15926059)
2006
38
The Baltimore activity scale for intermittent claudication: a validation study. (17038572)
2006
39
Relationship between soluble thrombomodulin in patients with intermittent claudication and critical ischemia. (15890390)
2006
40
Variability in responsiveness to clopidogrel in patients with intermittent claudication. (16549375)
2006
41
Effective training for patients with intermittent claudication. (16118073)
2005
42
Treatment of intermittent claudication: cilostazol. (15330347)
2004
43
Beta-adrenergic blocking agents and intermittent claudication: systematic review. (15516809)
2004
44
Randomized trial of AT-1015 for treatment of intermittent claudication. A novel 5-hydroxytryptamine antagonist with no evidence of efficacy. (15230484)
2004
45
Local infections after above-knee prosthetic femoropopliteal bypass for intermittent claudication. (15353114)
2004
46
Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model. (12907137)
2003
47
Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. (14504183)
2003
48
Endovascular stents for intermittent claudication. (12535463)
2003
49
The influence of iloprost on blood rheology and tissue perfusion in patients with intermittent claudication. (14618196)
2003
50
The intermittent claudication questionnaire: a patient-assessed condition-specific health outcome measure. (12368737)
2002

Genetic Variations for Intermittent Claudication

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Expression for genes affiliated with Intermittent Claudication

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Claudication

Search GEO for disease gene expression data for Intermittent Claudication.

Pathways for genes affiliated with Intermittent Claudication

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Intermittent Claudication

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Intermittent Claudication according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1pge24410.7PF4
2sarpogrelate hydrochloride4410.5THBD, SELP, HTR2A
3sodium chlorate4410.4FGF2, SELP, VWF, FGF1
4kininogen4410.4VWF
5raloxifene44 28 49 1113.4UGT1A1, CALCA
6fibrinopeptide a4410.3THBD, FGA, PF4
7iohexol4410.3PPBP, PF4, SELP, FGA
8hirudin4410.3THBD, SELP, VWF, PF4, FGA
9protamine4410.3PF4, FGF2, FGA, FGF1, SELP
10ticlopidine44 1111.3PF4, FGA, VWF, PPBP, SELP
11desmopressin44 59 28 1113.3PPBP, SELP, THBD, VWF
12polysulfone4410.2SELP, PF4, FGA, VWF, PPBP
13dexamethasone44 49 28 1113.2FGF2, UGT1A1, PPBP, FGF1
14norepinephrine44 11 2412.2FGF1, PPBP, KCNJ5, HTR2A, CALCA
156-ketoprostaglandin f1alpha4410.2THBD, VWF, FGA, PF4, PPBP
16creatinine4410.2FGA, THBD, PPBP, SAA4, SELP
17bivalirudin44 1111.2SELP, THBD, FGA
18thromboxane a244 2411.2PPBP, PF4, FGA, SELP, VWF
19heparin44 28 11 2413.2PGF, FGA, SELP, PF4, PPBP
20iloprost44 59 28 1113.2SELP, PF4, THBD, PPBP
21dermatan sulfate4410.2FGF1, VWF, FGF2, PF4, SELP, THBD
22warfarin44 49 11 2413.2PF4, FGA, FGF2, VWF, SELP, PPBP
23dipyridamole44 59 28 1113.2SELP, VWF, FGF2, FGA, PPBP, PF4
24pge14410.2PPBP, THBD, VWF, FGA, PF4
2511-dehydrothromboxane b24410.2PF4, PPBP, SELP, THBD, VWF, FGA
26txb24410.1VWF, SELP, FGA, PF4, PPBP, THBD
27thromboxane44 2411.1VWF, SELP, THBD, PPBP, PF4, FGA
28atorvastatin44 49 28 11 2414.1UGT1A1, PGF, VWF, THBD, SELP
29aprotinin44 1111.1THBD, FGA, PF4, PPBP, SELP, VWF
30ptca4410.1SELP, THBD, FGA, PF4, PPBP, SAA4
31latex4410.1PF4, FGA, SAA4, VWF, PPBP
32citrate4410.1PPBP, PF4, SELP, FGF2, VWF, THBD
335-hydroxytryptamine4410.1FGF2, THBD, CALCA, PF4, HTR2A
34thyroxine44 2411.1FGF2, VWF, THBD, CALCA, UGT1A1
35aspirin44 49 28 2413.0VWF, THBD, FGA, PF4, PPBP, SELP
36argatroban44 1111.0FGA, SELP, THBD
37epinephrine44 11 2412.0VWF, PPBP, SELP, FGA, CALCA, PF4
38hyaluronic acid44 2411.0FGF1, FGF2, PPBP, THBD, VWF
39fibrinogen449.9THBD, SELP, FGA, VWF, PF4, PPBP
40heparan sulfate44 2410.9PF4, THBD, FGF2, FGF1, PPBP
41nicotine44 49 28 1112.9VWF, UGT1A1, FGF2, PF4, CYP2A13
42histamine44 28 2411.9SELP, THBD, VWF, CALCA, FGA, PF4
43arachidonic acid44 28 11 2412.8SAA4, SELP, PPBP, UGT1A1, CYP2A13, PF4
44prostacyclin449.8PPBP, PF4, FGF1, FGA, FGF2, PGF
45lactate449.7KCNJ5, VWF, FGF1, PF4, CALCA, PPBP
46fluvastatin44 49 28 1112.7UGT1A1, THBD, SELP, VWF
47vegf449.6FGF1, FGF2, PGF, VWF, THBD, CALCA
48nitric oxide44 11 2411.6SELP, KCNJ5, FGF1, PPBP, CALCA, PGF
49cholesterol44 28 11 2412.6FGF1, LSS, FGA, SAA4, PPBP, SELP
50tyrosine449.4PPBP, SELP, UGT1A1, PF4, FGF1, FGA

GO Terms for genes affiliated with Intermittent Claudication

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16Gene Ontology
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Cellular components related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.3VWF, FGA
2platelet alpha granule lumenGO:0310939.9VWF, FGA, PF4, PPBP
3extracellular spaceGO:0056159.3CALCA, PPBP, PF4, FGF1, FGA, FGF2
4extracellular regionGO:0055768.9CALCA, SAA4, PPBP, PF4, FGF1, FGA

Biological processes related to Intermittent Claudication according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.2FGF2, FGF1
2positive regulation of macrophage differentiationGO:04565110.1PF4, CALCA
3positive regulation of cell divisionGO:05178110.0PPBP, FGF1, FGF2, PGF
4platelet degranulationGO:00257610.0SELP, VWF, FGA, PF4, PPBP
5platelet activationGO:0301689.9PPBP, PF4, FGA, VWF, SELP
6positive regulation of angiogenesisGO:0457669.8FGF1, FGF2, PGF
7blood coagulationGO:0075969.7PPBP, PF4, FGA, VWF, THBD, SELP

Molecular functions related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9PGF, FGF2, FGF1, PPBP
2heparin bindingGO:0082019.5SELP, PGF, FGF2, FGF1, PF4

Products for genes affiliated with Intermittent Claudication

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermittent Claudication

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet