MCID: INT002
MIFTS: 56

Intermittent Claudication malady

Summaries for Intermittent Claudication

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intermittent claudication (Latin: claudicatio intermittens) is a clinical diagnosis given for muscle... more...

MalaCards: Intermittent Claudication, also known as intermittent claudication nos, is related to ischemia and peripheral vascular disease. An important gene associated with Intermittent Claudication is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are GRB2:SOS provides linkage to MAPK signaling for Intergrins and FGFR1b ligand binding and activation. The drugs pentoxifylline and cilostazol and the compounds pge2 and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include endothelial, testes and bone, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Intermittent Claudication

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

intermittent claudication 8 10 44 30 60
intermittent claudication nos 8
charcot's syndrome 8


External Ids:

Disease Ontology8 DOID:3669
MeSH34 D007383

Related Diseases for Intermittent Claudication

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17GeneCards, 18GeneDecks
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Diseases related to Intermittent Claudication via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.8KCNJ5, PF4, FGF1, FGA, FGF2, PGF
2peripheral vascular disease30.7VWF, THBD, SELP
3vascular disease30.7HTR2A, PPBP, FGA, FGF2, VWF, THBD
4atherosclerosis30.5PF4, PPBP, SAA4, LSS, FGF1, FGA
5arteriosclerosis30.4FGF1
6diabetes mellitus30.4KCNJ5, CALCA, PF4, FGA, VWF, THBD
7arteriosclerosis obliterans30.3SELP, PF4
8stroke, ischemic30.3PPBP
9hypertension30.3PGF, PPBP, CALCA
10myocardial infarction30.3FGF1, FGA, PGF, VWF, SELP, PF4
11coronary artery disease30.3PGF, VWF, THBD, SELP, FGA, FGF1
12obesity30.1KCNJ5, SAA4, HTR2A
13proteinuria30.1SAA4, PF4, FGA, PGF
14pneumonia30.1FGA, SAA4
15spinal stenosis10.6
16critical limb ischemia10.4
17abdominal aortic aneurysm10.3
18aortic aneurysm10.3
19angina pectoris10.1
20arteriovenous fistula10.1
21carotid stenosis10.1
22pseudoxanthoma elasticum10.1
23noonan syndrome10.1
24spondylosis10.1
25neuronitis10.1
26systolic heart failure10.1
27cauda equina syndrome10.1
28amyloidosis10.1
29aortic disease10.1
30brain disease10.1
31carotid artery disease10.1
32cervicitis10.1
33compartment syndrome10.1
34lipoma10.1
35lymphangioma10.1
36neurofibroma10.1
37pancreatitis10.0SELP
38peritonitis10.0SELP
39hemangioma10.0FGF2
40psoriasis10.0SELP
41hepatitis10.0UGT1A1
42cystic fibrosis10.0HTR2A
43eclampsia10.0THBD
44cerebrovascular disease10.0SELP
45sarcoma10.0PGF
46leiomyoma10.0FGF1
47acute leukemia10.0FGA
48polycythemia10.0PPBP
49thyroiditis10.0CALCA
50dermatitis10.0PF4

Graphical network of the top 20 diseases related to Intermittent Claudication:



Diseases related to intermittent claudication

Clinical Features for Intermittent Claudication

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Drugs & Therapeutics for Intermittent Claudication

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intermittent Claudication

Drug clinical trials:

Search ClinicalTrials for Intermittent Claudication

Search NIH Clinical Center for Intermittent Claudication

Search CenterWatch for Intermittent Claudication

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intermittent Claudication cell therapies at LifeMap Discovery.

Genetic Tests for Intermittent Claudication

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Anatomical Context for Intermittent Claudication

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Intermittent Claudication:

32
Endothelial, Testes, Bone, Heart, Skeletal muscle, Skin, Spinal cord, Brain

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Intermittent Claudication:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate

Animal Models for Intermittent Claudication or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intermittent Claudication:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.8SELP, PGF, FGA, CALCA, KCNJ5

Publications for Intermittent Claudication

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50PubMed
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Articles related to Intermittent Claudication:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Exercise prescription using the heart of claudication pain onset in patients with intermittent claudication. (23917662)
2013
2
Authors' reply: systematic review of thea88efficacya88ofa88cilostazol,a88naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication (Br J Surg 2012; 99: 1630-1638). (24227373)
2013
3
Medical comorbidities but not interventions adversely affect survival in patients with intermittent claudication. (23972525)
2013
4
Cystic adventitial disease of the popliteal artery causing intermittent exertional claudication in a young male athlete: a case report. (23989350)
2013
5
Characteristics of Postural Sway during Quiet Standing Before and After the Occurrence of Neurogenic Intermittent Claudication in Female Patients with Degenerative Lumbar Spinal Canal Stenosis. (24259826)
2013
6
Compression of common peroneal nerve caused by an extraneural ganglion cyst mimicking intermittent claudication. (23721086)
2013
7
Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication. (24267241)
2013
8
Treatment of intermittent claudication. (23842826)
2013
9
Balance impairment, physical ability, and its link with disease severity in patients with intermittent claudication. (23084732)
2013
10
Percutaneous transluminal angioplasty results inA improved physical function but not balance inA patients with intermittent claudication. (23880550)
2013
11
Current treatment methods for long occlusions of the femoropopliteal segment in patients with intermittent claudication. Minireview. (23549509)
2013
12
Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. (22402934)
2012
13
Lessons learned from recent randomized clinical trials for intermittent claudication. (22511735)
2012
14
The ClaudicatioNet concept: design of a national integrated care network providing active and healthy aging for patients with intermittent claudication. (22942648)
2012
15
Adjunctive pharmacotherapies for intermittent claudication--NICE guidance. (21993771)
2012
16
Evaluation of patient compliance, quality of life impact and cost-effectiveness of a "test in-train out" exercise-based rehabilitation program for patients with intermittent claudication. (21712607)
2011
17
Efficacy of quantified home-based exercise and supervised exercise in patients with intermittent claudication: a randomized controlled trial. (21262997)
2011
18
I^-Blockers in patients with intermittent claudication and arterial hypertension: results from the nebivolol or metoprolol in arterial occlusive disease trial. (21646599)
2011
19
Optimizing supervised exercise therapy for patients with intermittent claudication. (20692797)
2010
20
Total sagittal spinal alignment in patients with lumbar canal stenosis accompanied by intermittent claudication. (20375774)
2010
21
Resting energy expenditure in patients with intermittent claudication and critical limb ischemia. (20382493)
2010
22
The effect of exercise on haemodynamics in intermittent claudication: a systematic review of randomized controlled trials. (20433214)
2010
23
Community trial of home-based exercise therapy for intermittent claudication. (19366815)
2009
24
Effects of exercise training on calf tissue oxygenation in men with intermittent claudication. (19854422)
2009
25
Neurogenic intermittent claudication in lumbar spinal canal stenosis: the clinical relationship between the local pressure of the intervertebral foramen and the clinical findings in lumbar spinal canal stenosis. (19342935)
2009
26
Predictors of walking distance after supervised exercise therapy in patients with intermittent claudication. (19540780)
2009
27
Eccentric strength and endurance in patients with unilateral intermittent claudication. (19488589)
2009
28
Profunda femoris as an access site vessel for a hybrid approach to the treatment of a para-anastomotic common iliac artery aneurysm and intermittent claudication, occurring after previous abdominal aortic thbe graft repair and femoro-femoral bypass graft. A case report. (20184072)
2009
29
Barriers and facilitators for walking in individuals with intermittent claudication. (18212396)
2008
30
Effects of policosanol (10 mg/d) versus aspirin (100 mg/d) in patients with intermittent claudication: a 10-week, randomized, comparative study. (18388038)
2008
31
Images in cardiovascular medicine. Intermittent claudication in a 28-year-old man with pseudoxanthoma elasticum. (18591453)
2008
32
Cost-effectiveness of endovascular revascularization compared to supervised hospital-based exercise training in patients with intermittent claudication: a randomized controlled trial. (18771879)
2008
33
The effect of hypercholestrolemia on calf muscle hemoglobin oxygen saturation in patients with intermittent claudication. (18388089)
2008
34
Intermittent claudication. (17615642)
2007
35
A pilot study of ranolazine in patients with intermittent claudication. (17164742)
2006
36
The constitutive procoagulant and hypofibrinolytic state in patients with intermittent claudication due to infrainguinal disease significantly improves with percutaneous transluminal balloon angioplasty. (16414385)
2006
37
Sarpogrelate, a 5-hT2A receptor antagonist in intermittent claudication. A phase II European study. (16886837)
2006
38
The patient with intermittent claudication. (15902804)
2005
39
Lacunar stroke in patients with intermittent claudication. (15740577)
2005
40
Surgical treatment for intermittent claudication in patients who do not improve with clinical treatment. (15340675)
2004
41
Flavonol and flavone intake and the risk of intermittent claudication in male smokers. (15180100)
2004
42
Reduction of remnant lipoprotein cholesterol concentrations by cilostazol in patients with intermittent claudication. (14644405)
2003
43
Effect of simvastatin versus placebo on treadmill exercise time until the onset of intermittent claudication in older patients with peripheral arterial disease at six months and at one year after treatment. (12972114)
2003
44
Effect of cilostazol on treadmill walking, community-based walking ability, and health-related quality of life in patients with intermittent claudication due to peripheral arterial disease: meta-analysis of six randomized controlled trials. (12473004)
2002
45
Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication. (12417278)
2002
46
Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudication. (11958389)
2001
47
Differential lipogenic effects of cilostazol and pentoxifylline in patients with intermittent claudication: potential role for interleukin-6. (11583728)
2001
48
Exercise training for intermittent claudication: does it adversely affect biochemical markers of the exercise-induced inflammatory response? (9413374)
1997
49
Is intermittent claudication in patients with peripheral arterial occlusive disease relieved under hyperbaric conditions? (9409184)
1997
50
Objective evaluation of cyclandelate in treatment of intermittent claudication associated with arteriosclerosis obliterans. (5866204)
1965

Genetic Variations for Intermittent Claudication

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Expression for genes affiliated with Intermittent Claudication

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Claudication

Search GEO for disease gene expression data for Intermittent Claudication.

Pathways for genes affiliated with Intermittent Claudication

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53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Intermittent Claudication

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Intermittent Claudication according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1pge24410.7PF4
2sarpogrelate hydrochloride4410.5THBD, SELP, HTR2A
3sodium chlorate4410.4FGF2, SELP, VWF, FGF1
4kininogen4410.4VWF
5raloxifene44 28 49 1113.4UGT1A1, CALCA
6fibrinopeptide a4410.3THBD, FGA, PF4
7iohexol4410.3PPBP, PF4, SELP, FGA
8hirudin4410.3THBD, SELP, VWF, PF4, FGA
9protamine4410.3PF4, FGF2, FGA, FGF1, SELP
10ticlopidine44 1111.3PF4, FGA, VWF, PPBP, SELP
11desmopressin44 59 28 1113.3PPBP, SELP, THBD, VWF
12polysulfone4410.2SELP, PF4, FGA, VWF, PPBP
13dexamethasone44 49 28 1113.2FGF2, UGT1A1, PPBP, FGF1
14norepinephrine44 11 2412.2FGF1, PPBP, KCNJ5, HTR2A, CALCA
156-ketoprostaglandin f1alpha4410.2THBD, VWF, FGA, PF4, PPBP
16creatinine4410.2FGA, THBD, PPBP, SAA4, SELP
17bivalirudin44 1111.2SELP, THBD, FGA
18thromboxane a244 2411.2PPBP, PF4, FGA, SELP, VWF
19heparin44 28 11 2413.2PGF, FGA, SELP, PF4, PPBP
20iloprost44 59 28 1113.2SELP, PF4, THBD, PPBP
21dermatan sulfate4410.2FGF1, VWF, FGF2, PF4, SELP, THBD
22warfarin44 49 11 2413.2PF4, FGA, FGF2, VWF, SELP, PPBP
23dipyridamole44 59 28 1113.2SELP, VWF, FGF2, FGA, PPBP, PF4
24pge14410.2PPBP, THBD, VWF, FGA, PF4
2511-dehydrothromboxane b24410.2PF4, PPBP, SELP, THBD, VWF, FGA
26txb24410.1VWF, SELP, FGA, PF4, PPBP, THBD
27thromboxane44 2411.1VWF, SELP, THBD, PPBP, PF4, FGA
28atorvastatin44 49 28 11 2414.1UGT1A1, PGF, VWF, THBD, SELP
29aprotinin44 1111.1THBD, FGA, PF4, PPBP, SELP, VWF
30ptca4410.1SELP, THBD, FGA, PF4, PPBP, SAA4
31latex4410.1PF4, FGA, SAA4, VWF, PPBP
32citrate4410.1PPBP, PF4, SELP, FGF2, VWF, THBD
335-hydroxytryptamine4410.1FGF2, THBD, CALCA, PF4, HTR2A
34thyroxine44 2411.1FGF2, VWF, THBD, CALCA, UGT1A1
35aspirin44 49 28 2413.0VWF, THBD, FGA, PF4, PPBP, SELP
36argatroban44 1111.0FGA, SELP, THBD
37epinephrine44 11 2412.0VWF, PPBP, SELP, FGA, CALCA, PF4
38hyaluronic acid44 2411.0FGF1, FGF2, PPBP, THBD, VWF
39fibrinogen449.9THBD, SELP, FGA, VWF, PF4, PPBP
40heparan sulfate44 2410.9PF4, THBD, FGF2, FGF1, PPBP
41nicotine44 49 28 1112.9VWF, UGT1A1, FGF2, PF4, CYP2A13
42histamine44 28 2411.9SELP, THBD, VWF, CALCA, FGA, PF4
43arachidonic acid44 28 11 2412.8SAA4, SELP, PPBP, UGT1A1, CYP2A13, PF4
44prostacyclin449.8PPBP, PF4, FGF1, FGA, FGF2, PGF
45lactate449.7KCNJ5, VWF, FGF1, PF4, CALCA, PPBP
46fluvastatin44 49 28 1112.7UGT1A1, THBD, SELP, VWF
47vegf449.6FGF1, FGF2, PGF, VWF, THBD, CALCA
48nitric oxide44 11 2411.6SELP, KCNJ5, FGF1, PPBP, CALCA, PGF
49cholesterol44 28 11 2412.6FGF1, LSS, FGA, SAA4, PPBP, SELP
50tyrosine449.4PPBP, SELP, UGT1A1, PF4, FGF1, FGA

GO Terms for genes affiliated with Intermittent Claudication

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16Gene Ontology
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Cellular components related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.3FGA, VWF
2platelet alpha granule lumenGO:0310939.9PPBP, PF4, FGA, VWF
3extracellular spaceGO:0056159.3FGA, FGF1, PF4, PPBP, CALCA, FGF2
4extracellular regionGO:0055768.9PGF, FGF2, FGA, VWF, FGF1, PF4

Biological processes related to Intermittent Claudication according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.2FGF2, FGF1
2positive regulation of macrophage differentiationGO:04565110.1PF4, CALCA
3positive regulation of cell divisionGO:05178110.0PPBP, FGF1, FGF2, PGF
4platelet degranulationGO:00257610.0SELP, VWF, FGA, PF4, PPBP
5platelet activationGO:0301689.9PPBP, PF4, FGA, VWF, SELP
6positive regulation of angiogenesisGO:0457669.8FGF1, FGF2, PGF
7blood coagulationGO:0075969.7PPBP, PF4, FGA, VWF, THBD, SELP

Molecular functions related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9PGF, FGF2, FGF1, PPBP
2heparin bindingGO:0082019.5SELP, PGF, FGF2, FGF1, PF4

Products for genes affiliated with Intermittent Claudication

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermittent Claudication

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet