MCID: INT002
MIFTS: 54

Intermittent Claudication malady

Summaries for Intermittent Claudication

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64Wikipedia, 33MalaCards
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Wikipedia:64 Intermittent claudication (Latin: claudicatio intermittens) is a clinical diagnosis given for muscle... more...

MalaCards: Intermittent Claudication, also known as intermittent claudication nos, is related to peripheral vascular disease and vascular disease. An important gene associated with Intermittent Claudication is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are GRB2:SOS provides linkage to MAPK signaling for Intergrins and FGFR1b ligand binding and activation. The drugs pentoxifylline and cilostazol and the compounds pge2 and sarpogrelate hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Intermittent Claudication

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

intermittent claudication 8 10 45 31 61
intermittent claudication nos 8
charcot's syndrome 8


External Ids:

Disease Ontology8 DOID:3669
MeSH35 D007383

Related Diseases for Intermittent Claudication

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Intermittent Claudication via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease30.7VWF, THBD, SELP
2vascular disease30.7HTR2A, PPBP, FGA, FGF2, VWF, THBD
3atherosclerosis30.6PF4, PPBP, SAA4, LSS, FGF1, FGA
4arteriosclerosis30.5FGF1
5arteriosclerosis obliterans30.4SELP, PF4
6stroke, ischemic30.4PPBP
7coronary artery disease,30.3PGF, VWF, THBD, SELP, FGA, FGF1
8insulin resistance30.1HTR2A, PGF, VWF
9spinal stenosis10.7
10cystic adventitial disease10.5
11critical limb ischemia10.5
12abdominal aortic aneurysm10.3
13n syndrome10.3
14aortic aneurysm10.3
15fibromuscular dysplasia10.3
16angina pectoris10.1
17carotid stenosis10.1
18pseudoxanthoma elasticum10.1
19noonan syndrome10.1
20spondylosis10.1
21systolic heart failure10.1
22cauda equina syndrome10.1
23amyloidosis10.1
24aortic disease10.1
25brain disease10.1
26hypoxia10.1
27brain ischemia10.1
28pancreatitis10.0SELP
29peritonitis10.0SELP
30hemangioma10.0FGF2
31psoriasis10.0SELP
32hepatitis10.0UGT1A1
33cystic fibrosis10.0HTR2A
34eclampsia10.0THBD
35cerebrovascular disease10.0SELP
36sarcoma10.0PGF
37leiomyoma10.0FGF1
38acute leukemia10.0FGA
39polycythemia10.0PPBP
40thyroiditis10.0CALCA
41dermatitis10.0PF4
42uremia10.0PF4, VWF
43placental insufficiency10.0PGF
44diabetic retinopathy10.0PGF, FGF2
45schistosomiasis10.0PPBP
46pulmonary embolism10.0PF4, FGA
47proliferative diabetic retinopathy10.0SELP, FGF2
48nephrotic syndrome10.0FGA, PPBP
49protein c deficiency10.0THBD
50thalassemia10.0UGT1A1

Graphical network of the top 20 diseases related to Intermittent Claudication:



Diseases related to intermittent claudication

Clinical Features for Intermittent Claudication

Drugs & Therapeutics for Intermittent Claudication

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intermittent Claudication

Drug clinical trials:

Search ClinicalTrials for Intermittent Claudication

Search NIH Clinical Center for Intermittent Claudication

Search CenterWatch for Intermittent Claudication

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intermittent Claudication cell therapies at LifeMap Discovery.

Genetic Tests for Intermittent Claudication

Anatomical Context for Intermittent Claudication

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Intermittent Claudication:

33
Spinal cord, Brain, Bone marrow, Heart, Skeletal muscle, Placenta, T cells, B cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Intermittent Claudication:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate

Animal Models for Intermittent Claudication or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Intermittent Claudication:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.8SELP, PGF, FGA, CALCA, KCNJ5

Publications for Intermittent Claudication

Sources:
51PubMed
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Articles related to Intermittent Claudication:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Effect of Cilostazol Prescribed in a Pragmatic Treatment Program for Intermittent Claudication. (24399131)
2014
2
Cost-Effectiveness of Cilostazol, Naftidrofuryl Oxalate, and Pentoxifylline for the Treatment of Intermittent Claudication in People With Peripheral Arterial Disease. (23378195)
2013
3
Treatment of intermittent claudication. (23842826)
2013
4
Circulating anti-beta2-glycoprotein I antibodies are associated with endothelial dysfunction, inflammation, and high nitrite plasma levels in patients with intermittent claudication. (24222887)
2013
5
Balance impairment, physical ability, and its link with disease severity in patients with intermittent claudication. (23084732)
2013
6
Naftidrofuryl for intermittent claudication. (23235580)
2012
7
Endurance athletes with intermittent claudication caused by iliac artery stenosis treated by endarterectomy with vein patch--short- and mid-term results. (22264590)
2012
8
SUPERvised exercise therapy or immediate PTA for intermittent claudication in patients with an iliac artery obstruction--a multicentre randomised controlled trial; SUPER study design and rationale. (22326696)
2012
9
Near-infrared spectroscopy assessment following exercise training in patients with intermittent claudication and in untrained healthy participants. (22529160)
2012
10
C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication: a prospective study. (22474034)
2012
11
Long-term effects of structured home-based exercise program on functional capacity and quality of life in patients with intermittent claudication. (21704786)
2011
12
Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication. (20889294)
2011
13
Prevalence and predictors of persistent health status impairment in patients referred to a vascular clinic with intermittent claudication. (21376642)
2011
14
Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study. (20101352)
2010
15
Test-retest reliability of isokinetic strength and endurance tests in patients with intermittent claudication. (20584820)
2010
16
The efficacy of oral beraprost sodium, a prostaglandin I2 analogue, for treating intermittent claudication in patients with arteriosclerosis obliterans. (20357749)
2010
17
Total sagittal spinal alignment in patients with lumbar canal stenosis accompanied by intermittent claudication. (20375774)
2010
18
Peripheral arterial disease and intermittent claudication: efficacy of short-term upper body strength training, dynamic exercise training, and advice to exercise at home. (20218480)
2009
19
Evaluation of a telephone clinic for patients with intermittent claudication. (19377396)
2009
20
Effects of exercise training on calf tissue oxygenation in men with intermittent claudication. (19854422)
2009
21
Two-year results of interspinous spacer (X-Stop) implantation in 175 patients with neurologic intermittent claudication due to lumbar spinal stenosis. (19387698)
2009
22
Cilostazol: new drug. Intermittent claudication: too little efficacy, too many risks. (19585717)
2009
23
Regarding "Altered fibrin clot structure and function in individuals with intermittent claudication". (19147322)
2009
24
Naftidrofuryl for intermittent claudication: meta-analysis based on individual patient data. (19276131)
2009
25
Resting energy expenditure in subjects with and without intermittent claudication. (19394975)
2009
26
Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. (18226561)
2008
27
A randomized trial of iloprost in patients with intermittent claudication. (18372433)
2008
28
Long-term effects of supervised exercise training on walking capacity and quality of life in patients with intermittent claudication. (18690592)
2008
29
Association between daily ambulatory activity patterns and exercise performance in patients with intermittent claudication. (18771878)
2008
30
Safety and efficacy of cilostazol in the management of intermittent claudication. (19337533)
2008
31
Clinical practice. Intermittent claudication. (17377162)
2007
32
Omega-3 fatty acids for intermittent claudication. (17943801)
2007
33
Adventitial cystic disease of the popliteal artery: a potential cause of intermittent claudication. (17427023)
2007
34
Completing the audit cycle: comparison of cardiac risk factor management in patients with intermittent claudication in two time periods. (17336105)
2007
35
The relationship between ankle-brachial index and leisure-time physical activity in patients with intermittent claudication. (17067975)
2006
36
Rapid foot and calf compression increases walking distance in patients with intermittent claudication: results of a randomized study. (15886663)
2005
37
The effect of exercise intensity on the response to exercise rehabilitation in patients with intermittent claudication. (16242558)
2005
38
PGE1 and other prostaglandins in the treatment of intermittent claudication: a meta-analysis. (16079924)
2005
39
Intermittent claudication in an Afghan hound due to aortic arteriosclerosis. (15822573)
2005
40
The patient with intermittent claudication. (15902804)
2005
41
Anticardiolipin antibodies as a risk factor of atherosclerosis in intermittent claudication. (15258681)
2004
42
Exercise rehabilitation for the patient with intermittent claudication: a highly effective yet underutilized treatment. (15379615)
2004
43
Surgical treatment for intermittent claudication in patients who do not improve with clinical treatment. (15340675)
2004
44
The role of cilostazol in the treatment of intermittent claudication. (15462700)
2004
45
Predictors of treatment outcome in intermittent claudication. (14652833)
2004
46
Gait analysis of patients with neurogenic intermittent claudication. (12435983)
2002
47
Management of intermittent claudication (Br J Surg 2002; 89: 529-31). (12296907)
2002
48
Differential lipogenic effects of cilostazol and pentoxifylline in patients with intermittent claudication: potential role for interleukin-6. (11583728)
2001
49
The white blood cell adhesion molecule E-selectin predicts restenosis in patients with intermittent claudication undergoing percutaneous transluminal angioplasty. (9133511)
1997
50
Uncommon causes of intermittent claudication: cystic adventitial disease of the popliteal artery and popliteal artery entrapment syndrome. (535000)
1979

Genetic Variations for Intermittent Claudication

Expression for genes affiliated with Intermittent Claudication

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Claudication

Search GEO for disease gene expression data for Intermittent Claudication.

Pathways for genes affiliated with Intermittent Claudication

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Compounds for genes affiliated with Intermittent Claudication

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB
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Compounds related to Intermittent Claudication according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1pge24510.7PF4
2sarpogrelate hydrochloride4510.5HTR2A, THBD, SELP
3sodium chlorate4510.4FGF1, FGF2, VWF, SELP
4kininogen4510.4VWF
5raloxifene45 29 50 1113.4CALCA, UGT1A1
6fibrinopeptide a4510.3PF4, FGA, THBD
7iohexol4510.3PPBP, PF4, FGA, SELP
8hirudin4510.3PF4, FGA, VWF, THBD, SELP
9protamine4510.3PF4, FGF1, FGA, FGF2, SELP
10ticlopidine45 1111.3PPBP, PF4, FGA, VWF, SELP
11desmopressin45 60 29 1113.3PPBP, VWF, THBD, SELP
12polysulfone4510.2PPBP, PF4, FGA, VWF, SELP
13dexamethasone45 50 29 1113.2FGF2, FGF1, UGT1A1, PPBP
14norepinephrine45 11 2412.2KCNJ5, CALCA, HTR2A, PPBP, FGF1
156-ketoprostaglandin f1alpha4510.2PPBP, PF4, FGA, VWF, THBD
16creatinine4510.2SELP, THBD, FGA, PPBP, SAA4
17bivalirudin45 1111.2FGA, THBD, SELP
18iloprost45 60 29 1113.2PPBP, PF4, THBD, SELP
19thromboxane a245 2411.2PPBP, PF4, FGA, VWF, SELP
20heparin45 29 11 2413.2PPBP, PF4, FGA, PGF, SELP
21dermatan sulfate4510.2PF4, FGF1, FGF2, VWF, THBD, SELP
22warfarin45 50 11 2413.2PPBP, PF4, FGA, FGF2, VWF, SELP
23dipyridamole45 60 29 1113.2PPBP, PF4, FGA, FGF2, VWF, SELP
24pge14510.2PPBP, PF4, FGA, VWF, THBD
2511-dehydrothromboxane b24510.2SELP, PPBP, PF4, FGA, VWF, THBD
26txb24510.1PPBP, PF4, FGA, VWF, THBD, SELP
27thromboxane45 2411.1PPBP, PF4, FGA, VWF, THBD, SELP
28atorvastatin45 50 29 11 2414.1UGT1A1, PGF, VWF, THBD, SELP
29aprotinin45 1111.1PPBP, PF4, FGA, VWF, THBD, SELP
30ptca4510.1SAA4, PPBP, PF4, FGA, THBD, SELP
31latex4510.1SAA4, PPBP, PF4, FGA, VWF
32citrate4510.1PPBP, PF4, FGF2, VWF, THBD, SELP
335-hydroxytryptamine4510.1CALCA, HTR2A, PF4, FGF2, THBD
34thyroxine45 2411.1CALCA, UGT1A1, FGF2, VWF, THBD
35aspirin45 50 29 2413.0PPBP, PF4, FGA, VWF, THBD, SELP
36argatroban45 1111.0FGA, THBD, SELP
37epinephrine45 11 2412.0CALCA, PPBP, PF4, FGA, VWF, SELP
38hyaluronic acid45 2411.0THBD, VWF, FGF2, FGF1, PPBP
39fibrinogen459.9SAA4, PPBP, PF4, FGA, VWF, THBD
40heparan sulfate45 2410.9THBD, FGF2, FGF1, PF4, PPBP
41nicotine45 50 29 1112.9VWF, FGF2, PF4, CYP2A13, UGT1A1
42histamine45 29 2411.9KCNJ5, CALCA, PPBP, PF4, FGA, VWF
43arachidonic acid45 29 11 2412.8SAA4, PPBP, UGT1A1, CYP2A13, PF4, FGF1
44prostacyclin459.8PPBP, PF4, FGF1, FGA, FGF2, PGF
45lactate459.7KCNJ5, CALCA, PPBP, PF4, FGF1, FGA
46fluvastatin45 50 29 1112.7SELP, THBD, VWF, UGT1A1
47vegf459.6CALCA, PPBP, PF4, FGF1, FGF2, PGF
48nitric oxide45 11 2411.6KCNJ5, CALCA, PPBP, FGF1, PGF, VWF
49cholesterol45 29 11 2412.6LSS, SAA4, PPBP, UGT1A1, PF4, FGF1
50tyrosine459.4KCNJ5, PPBP, UGT1A1, PF4, FGF1, FGA

GO Terms for genes affiliated with Intermittent Claudication

Sources:
16Gene Ontology
See all sources

Cellular components related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.3VWF, FGA
2platelet alpha granule lumenGO:0310939.9VWF, FGA, PF4, PPBP
3extracellular spaceGO:0056159.3CALCA, PPBP, PF4, FGF1, FGA, FGF2
4extracellular regionGO:0055768.9CALCA, SAA4, PPBP, PF4, FGF1, FGA

Biological processes related to Intermittent Claudication according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.2FGF2, FGF1
2positive regulation of macrophage differentiationGO:04565110.1PF4, CALCA
3positive regulation of cell divisionGO:05178110.0PPBP, FGF1, FGF2, PGF
4platelet degranulationGO:00257610.0SELP, VWF, FGA, PF4, PPBP
5platelet activationGO:0301689.9PPBP, PF4, FGA, VWF, SELP
6positive regulation of angiogenesisGO:0457669.8FGF1, FGF2, PGF
7blood coagulationGO:0075969.7PPBP, PF4, FGA, VWF, THBD, SELP

Molecular functions related to Intermittent Claudication according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9PGF, FGF2, FGF1, PPBP
2heparin bindingGO:0082019.5SELP, PGF, FGF2, FGF1, PF4

Products for genes affiliated with Intermittent Claudication

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermittent Claudication

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet