MCID: INT025
MIFTS: 39

Intermittent Explosive Disorder malady

Mental diseases category
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Summaries for Intermittent Explosive Disorder

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and bipolar disorder. An important gene associated with Intermittent Explosive Disorder is HTR1B (5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and SIDS Susceptibility Pathways. The compounds mcpp and pindolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:65 Intermittent explosive disorder (IED) is a behavioral disorder characterized by extreme expressions of... more...

Aliases & Classifications for Intermittent Explosive Disorder

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8Disease Ontology, 10DISEASES, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

intermittent explosive disorder 8 10 62
explosive personality disorder 8 62


External Ids:

Disease Ontology8 DOID:12401
ICD9CM27 312.34, 301.3
MeSH35 D007174

Related Diseases for Intermittent Explosive Disorder

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to intermittent explosive disorder

Symptoms for Intermittent Explosive Disorder

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Drugs & Therapeutics for Intermittent Explosive Disorder

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

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Anatomical Context for Intermittent Explosive Disorder

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33MalaCards
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MalaCards organs/tissues related to Intermittent Explosive Disorder:

33
Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5CGA, HTR1B, CHRNA7
2MP:00053798.5CGA, SLC6A4, HTR1B

Publications for Intermittent Explosive Disorder

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52PubMed
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Articles related to Intermittent Explosive Disorder:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. (24321204)
2014
2
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)
2013
3
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)
2013
4
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)
2013
5
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. (23719736)
2013
6
The prevalence and correlates of intermittent explosive disorder in Iraq. (22443168)
2012
7
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)
2012
8
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)
2012
9
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. (22535310)
2012
10
The relationship between childhood exposure to trauma and intermittent explosive disorder. (22464047)
2012
11
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. (20709410)
2011
12
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)
2011
13
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)
2011
14
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. (21295216)
2011
15
Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)
2010
16
A case of intermittent explosive disorder. (21694793)
2010
17
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)
2010
18
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)
2010
19
Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. (20672913)
2010
20
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)
2010
21
Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. (20496987)
2010
22
Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)
2009
23
A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)
2009
24
P3a and mismatch negativity in individuals with moderate Intermittent Explosive Disorder. (19463896)
2009
25
The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)
2008
26
Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)
2008
27
Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)
2008
28
EEG correlates of moderate intermittent explosive disorder. (18032100)
2008
29
Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)
2008
30
Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)
2007
31
Intermittent explosive disorder is common, has an early age of onset and is associated with the development of other mental disorders in the US population. (17255401)
2007
32
Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)
2006
33
Intermittent explosive disorder. (17131536)
2006
34
The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication. (16754840)
2006
35
Prevalence and features of intermittent explosive disorder in a clinical setting. (16259534)
2005
36
Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)
2004
37
Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)
2004
38
Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. (12900307)
2003
39
Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)
2002
40
Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)
2002
41
Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)
2002
42
Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)
2001
43
Intermittent explosive disorder. (11122935)
2000
44
Recognition and treatment of DSM-IV intermittent explosive disorder. (10418808)
1999
45
DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)
1998
46
Hypothalamic lesions and intermittent explosive disorder. (1627961)
1992
47
The diagnosis of intermittent explosive disorder in violent men. (2039850)
1991
48
Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)
1987
49
Therapeutic use of propranolol for intermittent explosive disorder. (3546964)
1987
50
Metoprolol for intermittent explosive disorder. (4025634)
1985

Variations for Intermittent Explosive Disorder

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Expression for genes affiliated with Intermittent Explosive Disorder

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

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50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 30KEGG, 55Reactome
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Compounds for genes affiliated with Intermittent Explosive Disorder

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45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1mcpp459.9SLC6A4, HTR1B
2pindolol45 29 1111.9SLC6A4, HTR1B
3nefazodone45 51 1111.9HTR1B, SLC6A4
4maoa459.9SLC6A4, HTR1B
5fenfluramine45 29 1111.9SLC6A4, HTR1B
6Serotonin249.8HTR1B, SLC6A4
7ketanserin45 2910.8HTR1B, SLC6A4
8clomipramine45 51 1111.8HTR1B, SLC6A4
9venlafaxine45 51 24 1112.8HTR1B, SLC6A4
10paroxetine45 51 29 1112.8SLC6A4, HTR1B
11quetiapine45 51 29 24 1113.8SLC6A4, HTR1B
12risperidone45 51 29 61 24 1114.8HTR1B, SLC6A4
13fluoxetine45 51 29 1112.8SLC6A4, HTR1B
14olanzapine45 51 29 24 1113.8SLC6A4, HTR1B
15lithium45 51 24 1112.8SLC6A4, HTR1B
16cabergoline45 29 1111.7CGA, HTR1B
17amine459.7SLC6A4, HTR1B
18bromocriptine45 29 1111.7CGA, HTR1B
19cocaine45 1110.7HTR1B, SLC6A4
20clonidine45 51 29 1112.7SLC6A4, CGA
21opiate459.7SLC6A4, CGA
22propranolol45 29 51 24 1113.7CGA, HTR1B
23progestin459.6CGA, SLC6A4
24verapamil45 29 51 24 1113.6CGA, SLC6A4
25dihydrotestosterone45 29 24 1112.6CGA, SLC6A4
26lobeline459.6SLC6A4, CHRNA7
27carbon459.6CGA, SLC6A4
28gnrh459.5CGA, SLC6A4
29mptp459.5SLC6A4, CHRNA7
30epinephrine45 24 1111.4SLC6A4, CGA
31choline45 24 1111.4SLC6A4, CHRNA7
32nicotine45 29 51 1112.3CHRNA7, SLC6A4
33tamoxifen45 51 29 1112.3CGA, SLC6A4
34gaba459.3SLC6A4, CHRNA7
35testosterone45 61 24 1112.2CGA, SLC6A4, HTR1B
36ondansetron51 45 24 1112.1SLC6A4, HTR1B, CHRNA7
37clozapine45 29 51 1112.0SLC6A4, HTR1B, CHRNA7
385-hydroxytryptamine459.0CHRNA7, HTR1B, SLC6A4
39nmda45 2910.0CHRNA7, SLC6A4
40norepinephrine45 24 1111.0CGA, SLC6A4
41acetylcholine45 51 29 24 1113.0CGA, CHRNA7
42aspartate458.9CHRNA7, SLC6A4, CGA
43glutamate458.8CHRNA7, SLC6A4, CGA
44alanine458.8CHRNA7, SLC6A4, CGA
45serine458.6CGA, SLC6A4, CHRNA7
46dopamine45 29 24 1111.4CHRNA7, HTR1B, SLC6A4, CGA

GO Terms for genes affiliated with Intermittent Explosive Disorder

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16Gene Ontology
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Cellular components related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.1SLC6A4, CHRNA7

Biological processes related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of organ growthGO:0466219.3CGA, SLC6A4
2vasoconstrictionGO:0423109.3SLC6A4, HTR1B
3response to hypoxiaGO:0016669.1SLC6A4, CHRNA7
4memoryGO:0076138.8SLC6A4, CHRNA7

Molecular functions related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1HTR1B, CHRNA7

Products for genes affiliated with Intermittent Explosive Disorder

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Sources for Intermittent Explosive Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet