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MCID: INT025
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Intermittent Explosive Disorder malady
1 gene, 1 tissue, 27 related diseases, clinical trials.

Summaries for Intermittent Explosive Disorder

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8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to borderline personality disorder and bipolar disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4), and among its related pathways are SIDS Susceptibility Pathways and Monoamine GPCRs. The compounds ondansetron and cabergoline have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia:64 Intermittent explosive disorder (IED) is a behavioral disorder characterized by extreme expressions of... more...

Aliases & Classifications for Intermittent Explosive Disorder

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Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

intermittent explosive disorder 8 10 61
explosive personality disorder 8 61


External Ids:

Disease Ontology8 DOID:12401
ICD9CM27 301.3, 312.34
MeSH35 D007174

Related Diseases for Intermittent Explosive Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder35.3SLC6A4, CGA, HTR1B
2bipolar disorder35.3CHRNA7, SLC6A4
3attention deficit hyperactivity disorder13.3SLC6A4, HTR1B
4parkinson's disease13.3SLC6A4, CHRNA7, HTR1B
5primary pulmonary hypertension13.3HTR1B, SLC6A4
6autistic disorder13.3SLC6A4, CHRNA7
7bulimia nervosa13.3HTR1B, SLC6A4
8antisocial personality disorder13.3SLC6A4, HTR1B
9obsessive-compulsive disorder13.3SLC6A4, HTR1B
10conduct disorder13.3SLC6A4, CGA
11schizoaffective disorder13.3SLC6A4, CHRNA7
12down syndrome13.3CHRNA7, CGA
13nicotine dependence13.3CHRNA7, SLC6A4
14central nervous system disease13.3CHRNA7, SLC6A4
15mood disorder13.3SLC6A4, HTR1B
16personality disorder13.3SLC6A4, HTR1B
17pre-eclampsia13.3CGA, SLC6A4
18psychotic disorder13.3SLC6A4, CHRNA7
19prader-willi syndrome10.2
20bipolar i disorder10.2
21premature ejaculation10.0SLC6A4
22hypertension10.0SLC6A4
23substance dependence10.0SLC6A4
24anxiety disorder10.0SLC6A4
25substance abuse10.0SLC6A4
26alcohol abuse10.0SLC6A4
27panic disorder10.0SLC6A4

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to intermittent explosive disorder

Clinical Features for Intermittent Explosive Disorder

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Drugs & Therapeutics for Intermittent Explosive Disorder

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intermittent Explosive Disorder

Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Search CenterWatch for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

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Anatomical Context for Intermittent Explosive Disorder

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33MalaCards
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MalaCards organs/tissues related to Intermittent Explosive Disorder:

33
Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Intermittent Explosive Disorder

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51PubMed
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Articles related to Intermittent Explosive Disorder:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)
2013
2
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)
2013
3
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)
2013
4
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. (23719736)
2013
5
The prevalence and correlates of intermittent explosive disorder in Iraq. (22443168)
2012
6
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)
2012
7
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)
2012
8
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. (22535310)
2012
9
The relationship between childhood exposure to trauma and intermittent explosive disorder. (22464047)
2012
10
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. (20709410)
2011
11
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)
2011
12
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)
2011
13
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. (21295216)
2011
14
Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)
2010
15
A case of intermittent explosive disorder. (21694793)
2010
16
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)
2010
17
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)
2010
18
Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. (20672913)
2010
19
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)
2010
20
Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. (20496987)
2010
21
A family history study of intermittent explosive disorder. (20488459)
2010
22
Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)
2009
23
A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)
2009
24
P3a and mismatch negativity in individuals with moderate Intermittent Explosive Disorder. (19463896)
2009
25
The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)
2008
26
Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)
2008
27
Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)
2008
28
EEG correlates of moderate intermittent explosive disorder. (18032100)
2008
29
Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)
2008
30
Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)
2007
31
Intermittent explosive disorder is common, has an early age of onset and is associated with the development of other mental disorders in the US population. (17255401)
2007
32
Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)
2006
33
Intermittent explosive disorder. (17131536)
2006
34
Prevalence and features of intermittent explosive disorder in a clinical setting. (16259534)
2005
35
Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)
2004
36
Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)
2004
37
Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. (12900307)
2003
38
Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)
2002
39
Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)
2002
40
Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)
2002
41
Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)
2001
42
Intermittent explosive disorder. (11122935)
2000
43
Recognition and treatment of DSM-IV intermittent explosive disorder. (10418808)
1999
44
Treatment of intermittent explosive disorder with sertraline in 3 patients. (10192598)
1999
45
DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)
1998
46
Intermittent explosive disorder-revised: development, reliability, and validity of research criteria. (9829145)
1998
47
The diagnosis of intermittent explosive disorder in violent men. (2039850)
1991
48
Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)
1987
49
Therapeutic use of propranolol for intermittent explosive disorder. (3546964)
1987
50
Metoprolol for intermittent explosive disorder. (4025634)
1985

Genetic Variations for Intermittent Explosive Disorder

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Expression for genes affiliated with Intermittent Explosive Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

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38NCBI BioSystems Database, 50PharmGKB, 30KEGG
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Pathways related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
SIDS Susceptibility Pathways38
10.0SLC6A4
2
Monoamine GPCRs38
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10.0SLC6A4
3
Circadian entrainment30
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10.0SLC6A4

Compounds for genes affiliated with Intermittent Explosive Disorder

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45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1ondansetron45 50 11 2413.8
2cabergoline29 45 1112.8
3bromocriptine29 45 1112.8
4propranolol45 29 50 11 2414.7
5dopamine45 29 11 2413.4SLC6A4
6clozapine45 29 50 1113.4SLC6A4
7lobeline4510.4SLC6A4
85-hydroxytryptamine4510.3SLC6A4
9mcpp4510.3SLC6A4
10pindolol45 29 1112.3SLC6A4
11maoa4510.3SLC6A4
12fenfluramine29 45 1112.3SLC6A4
13venlafaxine50 45 11 2413.3SLC6A4
14ketanserin29 4511.3SLC6A4
15paroxetine45 50 29 1113.3SLC6A4
16risperidone29 45 50 60 11 2415.3SLC6A4
17aspartate4510.3SLC6A4
18fluoxetine50 45 29 1113.3SLC6A4
19mptp4510.3SLC6A4
20clonidine45 29 1112.3SLC6A4
21testosterone45 60 11 2413.2SLC6A4
22opiate4510.2SLC6A4
23progestin4510.2SLC6A4
24amine4510.2SLC6A4
25glutamate4510.2SLC6A4
26alanine4510.2SLC6A4
27verapamil45 50 29 11 2414.1SLC6A4
28cocaine45 1111.1SLC6A4
29dihydrotestosterone45 29 11 2413.1SLC6A4
30choline45 11 2412.0SLC6A4
31carbon4510.0SLC6A4
32gaba4510.0SLC6A4
33nicotine45 50 29 1112.9SLC6A4
34gnrh459.7SLC6A4

GO Terms for genes affiliated with Intermittent Explosive Disorder

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16Gene Ontology
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Biological processes related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of organ growthGO:04662110.0SLC6A4
2response to hypoxiaGO:00166610.0SLC6A4
3vasoconstrictionGO:0423109.9SLC6A4
4memoryGO:0076139.7SLC6A4

Products for genes affiliated with Intermittent Explosive Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intermittent Explosive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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