MCID: INT025
MIFTS: 32

Intermittent Explosive Disorder malady

Summaries for Intermittent Explosive Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to borderline personality disorder and bipolar disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4), and among its related pathways are SIDS Susceptibility Pathways and Monoamine GPCRs. The compounds ondansetron and cabergoline have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia:63 Intermittent explosive disorder (IED) is a behavioral disorder characterized by extreme expressions of... more...

Aliases & Classifications for Intermittent Explosive Disorder

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

intermittent explosive disorder 8 10 60
explosive personality disorder 8 60


External Ids:

Disease Ontology8 DOID:12401
ICD9CM27 301.3, 312.34
MeSH34 D007174

Related Diseases for Intermittent Explosive Disorder

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to intermittent explosive disorder

Clinical Features for Intermittent Explosive Disorder

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Drugs & Therapeutics for Intermittent Explosive Disorder

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intermittent Explosive Disorder

Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Search CenterWatch for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

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Anatomical Context for Intermittent Explosive Disorder

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32MalaCards
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MalaCards organs/tissues related to Intermittent Explosive Disorder:

32
Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

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Publications for Intermittent Explosive Disorder

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50PubMed
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Articles related to Intermittent Explosive Disorder:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. (24321204)
2014
2
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)
2013
3
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)
2013
4
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)
2013
5
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. (23719736)
2013
6
The prevalence and correlates of intermittent explosive disorder in Iraq. (22443168)
2012
7
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)
2012
8
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)
2012
9
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. (22535310)
2012
10
The relationship between childhood exposure to trauma and intermittent explosive disorder. (22464047)
2012
11
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. (20709410)
2011
12
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)
2011
13
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)
2011
14
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. (21295216)
2011
15
Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)
2010
16
A case of intermittent explosive disorder. (21694793)
2010
17
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)
2010
18
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)
2010
19
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)
2010
20
Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. (20496987)
2010
21
A family history study of intermittent explosive disorder. (20488459)
2010
22
Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)
2009
23
A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)
2009
24
The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)
2008
25
Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)
2008
26
Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)
2008
27
EEG correlates of moderate intermittent explosive disorder. (18032100)
2008
28
Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)
2008
29
Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)
2007
30
Intermittent explosive disorder is common, has an early age of onset and is associated with the development of other mental disorders in the US population. (17255401)
2007
31
Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)
2006
32
Intermittent explosive disorder. (17131536)
2006
33
The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication. (16754840)
2006
34
Prevalence and features of intermittent explosive disorder in a clinical setting. (16259534)
2005
35
Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)
2004
36
Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)
2004
37
Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. (12900307)
2003
38
Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)
2002
39
Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)
2002
40
Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)
2002
41
Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)
2001
42
Intermittent explosive disorder. (11122935)
2000
43
Recognition and treatment of DSM-IV intermittent explosive disorder. (10418808)
1999
44
DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)
1998
45
Intermittent explosive disorder-revised: development, reliability, and validity of research criteria. (9829145)
1998
46
Hypothalamic lesions and intermittent explosive disorder. (1627961)
1992
47
The diagnosis of intermittent explosive disorder in violent men. (2039850)
1991
48
Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)
1987
49
Therapeutic use of propranolol for intermittent explosive disorder. (3546964)
1987
50
Metoprolol for intermittent explosive disorder. (4025634)
1985

Genetic Variations for Intermittent Explosive Disorder

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Expression for genes affiliated with Intermittent Explosive Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

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37NCBI BioSystems Database, 49PharmGKB, 29KEGG
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Pathways related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SLC6A4
2
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10.0SLC6A4
3
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10.0SLC6A4

Compounds for genes affiliated with Intermittent Explosive Disorder

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1ondansetron44 49 11 2413.8
2cabergoline28 44 1112.8
3bromocriptine28 44 1112.8
4propranolol44 28 49 11 2414.7
5dopamine44 28 11 2413.4SLC6A4
6clozapine44 28 49 1113.4SLC6A4
7lobeline4410.4SLC6A4
85-hydroxytryptamine4410.3SLC6A4
9mcpp4410.3SLC6A4
10pindolol44 28 1112.3SLC6A4
11maoa4410.3SLC6A4
12fenfluramine28 44 1112.3SLC6A4
13venlafaxine49 44 11 2413.3SLC6A4
14ketanserin28 4411.3SLC6A4
15paroxetine44 49 28 1113.3SLC6A4
16risperidone28 44 49 59 11 2415.3SLC6A4
17aspartate4410.3SLC6A4
18fluoxetine49 44 28 1113.3SLC6A4
19mptp4410.3SLC6A4
20clonidine44 28 1112.3SLC6A4
21testosterone44 59 11 2413.2SLC6A4
22opiate4410.2SLC6A4
23progestin4410.2SLC6A4
24amine4410.2SLC6A4
25glutamate4410.2SLC6A4
26alanine4410.2SLC6A4
27verapamil44 49 28 11 2414.1SLC6A4
28cocaine44 1111.1SLC6A4
29dihydrotestosterone44 28 11 2413.1SLC6A4
30choline44 11 2412.0SLC6A4
31carbon4410.0SLC6A4
32gaba4410.0SLC6A4
33nicotine44 49 28 1112.9SLC6A4
34gnrh449.7SLC6A4

GO Terms for genes affiliated with Intermittent Explosive Disorder

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16Gene Ontology
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Biological processes related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of organ growthGO:04662110.0SLC6A4
2response to hypoxiaGO:00166610.0SLC6A4
3vasoconstrictionGO:0423109.9SLC6A4
4memoryGO:0076139.7SLC6A4

Products for genes affiliated with Intermittent Explosive Disorder

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  • Antibodies
  • Proteins
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Sources for Intermittent Explosive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet