MCID: INT025
MIFTS: 38

Intermittent Explosive Disorder malady

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

Aliases & Descriptions for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 14 69
Explosive Personality Disorder 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD10 33 F60.3 F63.81
ICD9CM 35 301.3 312.34
MeSH 42 D007174
NCIt 47 C94332

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to pyromania and coloboma of iris. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Monoamine GPCRs. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include amygdala and brain, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia : 71 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 pyromania 11.0
2 coloboma of iris 10.2 CRP IL6
3 apperceptive agnosia 10.2 CRP HTR1A SLC6A4
4 tactile agnosia 10.2 SMOC1 SMUG1
5 dry eye syndrome 10.2 HTR1A HTR7 SLC6A4
6 renpenning syndrome 10.2 HTR1A HTR7 SLC6A4
7 cutaneous sclerosis 10.2 CRP IL6
8 antisocial personality disorder 10.2 HTR1A SMOC1
9 tinea pedis 10.1 HTR1A HTR7 SLC6A4
10 human immunodeficiency virus infectious disease 10.1 CRP IL6 SMUG1
11 keratosis 10.1 HTR1A HTR7 SLC6A4
12 lichen disease 10.1 HTR1A IL6 SLC6A4
13 toxic myocarditis 10.1 ADRB1 CRP IL6
14 fallopian tube adenomatoid tumor 10.1 CRP SMUG1
15 abnormal pupillary function 10.1 HTR1A HTR7
16 stiff-person syndrome 10.1 CRP IL6 SMUG1
17 shoulder impingement syndrome 10.1 CRP IL6
18 chronic eosinophilic pneumonia 10.1 HTR1A PRL SLC6A4
19 ellis-van creveld syndrome 10.1 CHRFAM7A CHRNA7 HTR1A SLC6A4
20 unilateral multicystic dysplastic kidney 10.1 CRP IL6
21 nodular nonsuppurative panniculitis 10.1 CRP IL6 SMOC1
22 personality disorder 10.0
23 conjunctival pigmentation 10.0 HTR7 SLC6A4
24 adrenal adenoma 10.0 CRP IL6 NPY
25 benign epilepsy with centrotemporal spikes 10.0 HTR1A IL6 NPY SLC6A4
26 chronic conjunctivitis 10.0 CHRNA7 HTR1A PRL SLC6A4
27 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.0 NPY PRL SLC6A4
28 alzheimer disease 17 10.0 HTR1A HTR7 PRL SLC6A4
29 hepatitis d 10.0 HTR1A NPY PRL SLC6A4
30 microcephaly 13, primary, autosomal recessive 9.9 GOLPH3 HTR1A HTR7 SLC6A4
31 body dysmorphic disorder 9.9 CRP IL6 NPY PRL
32 breast hemangiopericytoma 9.9 CRP IL6 PRL SMOC1
33 mucinous adenocarcinoma 9.9 GABRA2 NPY PRL SLC6A4
34 autism spectrum disorder 9.9 HTR7 MFAP4 SLC6A4
35 preeclampsia/eclampsia 5 9.8 GABRA2 HTR1A HTR7 NPY SLC6A4
36 obsessive-compulsive disorder 9.8
37 prader-willi syndrome 9.8
38 bipolar disorder 9.8
39 borderline personality disorder 9.8
40 obsessive-compulsive personality disorder 9.8
41 avoidant personality disorder 9.8
42 schizophrenia 9.5 CHRFAM7A CHRNA7 CRP HTR1A HTR7 NPY
43 luxation of globe 7.9 ADRB1 CGA CHRFAM7A CHRNA7 CRP CTSH

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 HTR7 IL6 NPY PRL SLC6A4 SMUG1
2 nervous system MP:0003631 9.32 CGA CHRNA7 GABRA2 HTR1A HTR7 IL6

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
3 Adrenergic Agents Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic alpha-2 Receptor Agonists Phase 4
6 Adrenergic alpha-Agonists Phase 4
7 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
8 Antihypertensive Agents Phase 4
9
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
10 Serotonin Agents Phase 4,Phase 3,Phase 2
11 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
12 Serotonin 5-HT1 Receptor Agonists Phase 4
13
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
14
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
15 Serotonin Antagonists Phase 3
16 Tranquilizing Agents Phase 3
17 Dopamine Agents Phase 3
18 Dopamine Antagonists Phase 3
19 Psychotropic Drugs Phase 3,Phase 2
20 Antipsychotic Agents Phase 3
21 Central Nervous System Depressants Phase 3
22
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
23 SRX246 Phase 1, Phase 2
24 Serotonin Uptake Inhibitors Phase 2
25 Natriuretic Agents Phase 1, Phase 2
26 Coagulants Phase 1, Phase 2
27 Neurotransmitter Uptake Inhibitors Phase 2
28 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
29 Cytochrome P-450 Enzyme Inhibitors Phase 2
30 Hemostatics Phase 1, Phase 2
31 Hormones Phase 1, Phase 2
32 Vasopressins Phase 1, Phase 2
33 Antidepressive Agents Phase 2
34 Antidepressive Agents, Second-Generation Phase 2
35 Arginine Vasopressin Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Unknown status NCT02048241 Phase 4
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4
3 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3
4 Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
5 Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder Completed NCT02055638 Phase 1, Phase 2
6 A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder Completed NCT00078754 Phase 2
7 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED Completed NCT00127400 Phase 2

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

39
Amygdala, Brain

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 82)
id Title Authors Year
1
Amygdala hyperactivation to angry faces in intermittent explosive disorder. ( 27145325 )
2016
2
Social cognition in Intermittent Explosive Disorder and aggression. ( 27621104 )
2016
3
Negative urgency and reward/punishment sensitivity in intermittent explosive disorder. ( 27155024 )
2016
4
Prevalence of DSM-IV Intermittent Explosive Disorder in Black Adolescents: Findings From the National Survey of American Life, Adolescent Supplement. ( 27078052 )
2016
5
Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. ( 27624432 )
2016
6
The cross-national epidemiology of DSM-IV intermittent explosive disorder. ( 27572872 )
2016
7
Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). ( 28088746 )
2016
8
Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. ( 27693977 )
2016
9
Substance use disorders: Relationship with intermittent explosive disorder and with aggression, anger, and impulsivity. ( 27442963 )
2016
10
Defense styles in Intermittent Explosive Disorder. ( 27086223 )
2016
11
Single Case Study: Neuropsychological Functioning in a Patient Diagnosed with Intermittent Explosive Disorder Pre and Post Neurosurgery. ( 27161981 )
2016
12
White Matter Integrity Reductions in Intermittent Explosive Disorder. ( 27206265 )
2016
13
Verbal versus physical aggression in Intermittent Explosive Disorder. ( 25534757 )
2015
14
The experience of aggressive outbursts in Intermittent Explosive Disorder. ( 25541537 )
2015
15
The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. ( 25754605 )
2015
16
Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. ( 26105140 )
2015
17
Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder. ( 26277033 )
2015
18
Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. ( 25477263 )
2015
19
Emotion regulation deficits in intermittent explosive disorder. ( 27539871 )
2015
20
Intermittent Explosive Disorder and aversive parental care. ( 25064384 )
2014
21
Emotion regulation deficits in intermittent explosive disorder. ( 25403171 )
2014
22
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. ( 24760575 )
2014
23
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
24
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. ( 24321204 )
2014
25
Intermittent explosive disorder: a study in personalized psychopharmacotherapy. ( 24441311 )
2014
26
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. ( 25300440 )
2014
27
History of childhood maltreatment in intermittent explosive disorder and suicidal behavior. ( 24935900 )
2014
28
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. ( 24582164 )
2014
29
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. ( 25106072 )
2014
30
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. ( 24907536 )
2014
31
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. ( 23950885 )
2013
32
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. ( 23835102 )
2013
33
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. ( 24352431 )
2013
34
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. ( 23719736 )
2013
35
The prevalence and correlates of intermittent explosive disorder in Iraq. ( 22443168 )
2012
36
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. ( 22535310 )
2012
37
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. ( 22464337 )
2012
38
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. ( 22752056 )
2012
39
The relationship between childhood exposure to trauma and intermittent explosive disorder. ( 22464047 )
2012
40
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. ( 21812102 )
2011
41
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. ( 20709410 )
2011
42
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. ( 21295216 )
2011
43
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. ( 21786470 )
2011
44
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. ( 19767013 )
2010
45
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. ( 21147742 )
2010
46
A family history study of intermittent explosive disorder. ( 20488459 )
2010
47
Latent structure of intermittent explosive disorder in an epidemiological sample. ( 20064645 )
2010
48
Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. ( 20672913 )
2010
49
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. ( 19822329 )
2010
50
Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. ( 20496987 )
2010

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for Intermittent Explosive Disorder

GO Terms for Intermittent Explosive Disorder

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.76 CRP CTSH IL6 SLC6A4
2 circadian rhythm GO:0007623 9.58 HTR7 PRL SLC6A4
3 positive regulation of JAK-STAT cascade GO:0046427 9.43 IL6 PRL
4 positive regulation of cell proliferation GO:0008284 9.43 CGA CHRNA7 CTSH HTR1A IL6 PRL
5 behavior GO:0007610 9.37 HTR1A NPY
6 negative regulation of organ growth GO:0046621 9.32 CGA SLC6A4
7 negative regulation of lipid storage GO:0010888 9.26 CRP IL6
8 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.16 HTR1A HTR7
9 vasoconstriction GO:0042310 8.8 HTR1A HTR7 SLC6A4

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 CGA NPY PRL
2 serotonin binding GO:0051378 8.96 HTR1A HTR7
3 extracellular ligand-gated ion channel activity GO:0005230 8.8 CHRFAM7A CHRNA7 GABRA2

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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