MCID: INT025
MIFTS: 42

Intermittent Explosive Disorder

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 14 69
Explosive Personality Disorder 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD10 32 F60.3 F63.81
ICD9CM 34 301.3 312.34
MeSH 41 D007174
NCIt 46 C94332

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to disease of mental health and obsessive-compulsive disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include amygdala and brain, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia : 72 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 disease of mental health 30.2 HTR1A HTR7 SLC6A4
2 obsessive-compulsive disorder 29.8 HTR1A PRL SLC6A4
3 bipolar disorder 29.4 CHRNA7 HTR1A PRL SLC6A4
4 pyromania 11.1
5 dissociative amnesia 10.4 HTR1A SMUG1
6 atypical depressive disorder 10.4 HTR7 SLC6A4
7 phobic disorder 10.4 HTR1A SLC6A4
8 ovarian squamous cell carcinoma 10.4 CRP SMUG1
9 periodic limb movement disorder 10.3 HTR1A SLC6A4
10 aortitis 10.3 CRP SMUG1
11 cold agglutinin disease 10.3 CRP IL6
12 diabetic foot ulcers 10.3 CRP IL6
13 cryopyrin-associated periodic syndrome 10.3 CRP IL6
14 neutrophilia, hereditary 10.3 CRP IL6
15 acute cholangitis 10.3 CRP IL6
16 rumination disorder 10.3 HTR1A HTR7
17 cardiogenic shock 10.3 CRP IL6
18 cartilage disease 10.3 CRP SMUG1
19 dysthymic disorder 10.3 HTR7 SLC6A4
20 uremic pruritus 10.3 CRP IL6
21 spinal disease 10.3 CRP IL6
22 castleman disease 10.2 CRP IL6
23 alexithymia 10.2 CRP HTR1A SLC6A4
24 premature ejaculation 10.2 HTR1A SLC6A4
25 microscopic colitis 10.2 IL6 SLC6A4
26 angina pectoris 10.2 CRP IL6
27 psychosexual disorder 10.2 HTR1A HTR7 SLC6A4
28 chronic fatigue syndrome 10.2 HTR1A IL6 SLC6A4
29 kleptomania 10.2 HTR1A HTR7 SLC6A4
30 brunner syndrome 10.2 HTR1A HTR7 SLC6A4
31 mental depression 10.2 HTR1A HTR7 SLC6A4
32 chronic pulmonary heart disease 10.2 HTR7 SLC6A4
33 social phobia 10.2 PRL SLC6A4
34 viral pneumonia 10.2 CRP IL6
35 motion sickness 10.1 HTR1A HTR7
36 systolic heart failure 10.1 ADRB1 CRP IL6
37 personality disorder 10.1
38 melancholia 10.1 CRP PRL
39 central nervous system vasculitis 10.1 CRP IL6 SMUG1
40 schizoaffective disorder 10.1 CHRFAM7A PRL SLC6A4
41 temporal arteritis 10.1 CRP IL6 SMUG1
42 anxiety 10.1 HTR1A NPY SLC6A4
43 postpartum depression 10.1 HTR1A PRL SLC6A4
44 migraine without aura 10.0 HTR1A PRL SLC6A4
45 bulimia nervosa 1 10.0 HTR7 NPY SLC6A4
46 coronary artery anomaly 10.0 ADRB1 CRP IL6
47 cecal disease 10.0 CRP IL6
48 stereotypic movement disorder 10.0 NPY PRL
49 relapsing polychondritis 9.9 CRP IL6
50 overnutrition 9.9 CRP IL6 NPY

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ADRB1 CGA CHRNA7 CRP GABRA2 HTR1A
2 nervous system MP:0003631 9.28 CGA CHRNA7 GABRA2 HTR1A HTR7 IL6

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
3
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
4 Adrenergic Agents Phase 4
5 Adrenergic Agonists Phase 4
6 Adrenergic alpha-2 Receptor Agonists Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Antihypertensive Agents Phase 4
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
10
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
11 Serotonin Agents Phase 4,Phase 3,Phase 2
12 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
13 Serotonin 5-HT1 Receptor Agonists Phase 4
14
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
15
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
16 Antipsychotic Agents Phase 3
17 Central Nervous System Depressants Phase 3
18 Dopamine Agents Phase 3
19 Dopamine Antagonists Phase 3
20 Psychotropic Drugs Phase 3,Phase 2
21 Serotonin Antagonists Phase 3
22 Tranquilizing Agents Phase 3
23
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
24
Quinidine Approved, Investigational Phase 2 56-54-2 441074
25 Arginine Vasopressin Phase 1, Phase 2
26 Coagulants Phase 1, Phase 2
27 Hemostatics Phase 1, Phase 2
28 Hormones Phase 1, Phase 2
29 Natriuretic Agents Phase 1, Phase 2
30 SRX246 Phase 1, Phase 2
31 Vasopressins Phase 1, Phase 2
32 Antidepressive Agents Phase 2
33 Antidepressive Agents, Second-Generation Phase 2
34 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
35 Cytochrome P-450 Enzyme Inhibitors Phase 2
36 Neurotransmitter Uptake Inhibitors Phase 2
37 Serotonin Uptake Inhibitors Phase 2
38 Quinidine gluconate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
3 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
4 Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder Completed NCT02055638 Phase 1, Phase 2 SRX246;Placebo
5 Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
6 A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder Completed NCT00078754 Phase 2 Fluoxetine;Divalproex;Placebo
7 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED Completed NCT00127400 Phase 2
8 Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Intermittent Explosive Disorder Recruiting NCT03420222 Phase 2 AVP-786;Placebo

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

38
Amygdala, Brain

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 86)
# Title Authors Year
1
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. ( 29106553 )
2018
2
A Wait-List Controlled Study of a Trauma-Focused Cognitive Behavioral Treatment for Intermittent Explosive Disorder in Timor-Leste. ( 28749158 )
2017
3
Intermittent explosive disorder and eating disorders: Analysis of national comorbidity and research samples. ( 28324677 )
2017
4
Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample. ( 28252880 )
2017
5
Single Case Study: Neuropsychological Functioning in a Patient Diagnosed with Intermittent Explosive Disorder Pre and Post Neurosurgery. ( 27161981 )
2016
6
Substance use disorders: Relationship with intermittent explosive disorder and with aggression, anger, and impulsivity. ( 27442963 )
2016
7
The cross-national epidemiology of DSM-IV intermittent explosive disorder. ( 27572872 )
2016
8
Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). ( 28088746 )
2016
9
Prevalence of DSM-IV Intermittent Explosive Disorder in Black Adolescents: Findings From the National Survey of American Life, Adolescent Supplement. ( 27078052 )
2016
10
Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. ( 27693977 )
2016
11
White Matter Integrity Reductions in Intermittent Explosive Disorder. ( 27206265 )
2016
12
Social cognition in Intermittent Explosive Disorder and aggression. ( 27621104 )
2016
13
Negative urgency and reward/punishment sensitivity in intermittent explosive disorder. ( 27155024 )
2016
14
Amygdala hyperactivation to angry faces in intermittent explosive disorder. ( 27145325 )
2016
15
Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. ( 27624432 )
2016
16
Defense styles in Intermittent Explosive Disorder. ( 27086223 )
2016
17
Verbal versus physical aggression in Intermittent Explosive Disorder. ( 25534757 )
2015
18
The experience of aggressive outbursts in Intermittent Explosive Disorder. ( 25541537 )
2015
19
The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. ( 25754605 )
2015
20
Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. ( 26105140 )
2015
21
Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder. ( 26277033 )
2015
22
Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. ( 25477263 )
2015
23
Emotion regulation deficits in intermittent explosive disorder. ( 27539871 )
2015
24
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. ( 24907536 )
2014
25
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
26
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. ( 24760575 )
2014
27
History of childhood maltreatment in intermittent explosive disorder and suicidal behavior. ( 24935900 )
2014
28
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. ( 24582164 )
2014
29
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. ( 25300440 )
2014
30
Intermittent explosive disorder: a study in personalized psychopharmacotherapy. ( 24441311 )
2014
31
Emotion regulation deficits in intermittent explosive disorder. ( 25403171 )
2014
32
Intermittent Explosive Disorder and aversive parental care. ( 25064384 )
2014
33
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. ( 24321204 )
2014
34
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. ( 25106072 )
2014
35
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. ( 23950885 )
2013
36
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. ( 24352431 )
2013
37
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. ( 23835102 )
2013
38
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. ( 23719736 )
2013
39
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. ( 22464337 )
2012
40
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. ( 22535310 )
2012
41
The prevalence and correlates of intermittent explosive disorder in Iraq. ( 22443168 )
2012
42
The relationship between childhood exposure to trauma and intermittent explosive disorder. ( 22464047 )
2012
43
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. ( 22752056 )
2012
44
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. ( 21812102 )
2011
45
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. ( 21786470 )
2011
46
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. ( 21295216 )
2011
47
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. ( 20709410 )
2011
48
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. ( 19767013 )
2010
49
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. ( 21147742 )
2010
50
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. ( 19822329 )
2010

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for Intermittent Explosive Disorder

Pathways related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 ADRB1 CGA CHRNA7 GABRA2 HTR1A HTR7
2 11.82 ADRB1 CGA HTR7
3
Show member pathways
11.64 ADRB1 HTR1A HTR7
4 11.6 HTR1A HTR7 SLC6A4
5 11.41 CGA IL6 PRL
6 11.23 CHRFAM7A CHRNA7 HTR1A IL6 SLC6A4
7 11.06 ADRB1 CGA NPY
8 10.82 ADRB1 NPY
9 10.71 CRP IL6
10 10.58 HTR1A HTR7 SLC6A4

GO Terms for Intermittent Explosive Disorder

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.76 CRP CTSH IL6 SLC6A4
2 cell proliferation GO:0008283 9.73 GOLPH3 HTR1A NPY PRL
3 positive regulation of cell proliferation GO:0008284 9.65 CGA CHRNA7 CTSH HTR1A IL6
4 positive regulation of JAK-STAT cascade GO:0046427 9.4 IL6 PRL
5 behavior GO:0007610 9.37 HTR1A NPY
6 negative regulation of organ growth GO:0046621 9.32 CGA SLC6A4
7 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
8 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 8.96 HTR1A HTR7
9 vasoconstriction GO:0042310 8.8 HTR1A HTR7 SLC6A4

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 CGA NPY PRL
2 neurotransmitter receptor activity GO:0030594 9.32 HTR1A HTR7
3 G-protein coupled serotonin receptor activity GO:0004993 9.26 HTR1A HTR7
4 serotonin binding GO:0051378 8.96 HTR1A HTR7
5 extracellular ligand-gated ion channel activity GO:0005230 8.8 CHRFAM7A CHRNA7 GABRA2

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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