MCID: INT025
MIFTS: 38

Intermittent Explosive Disorder

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 14 69
Explosive Personality Disorder 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD10 33 F60.3 F63.81
ICD9CM 35 301.3 312.34
MeSH 42 D007174
NCIt 47 C94332

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and pyromania. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include amygdala and brain, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia : 72 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 personality disorder 30.4 HTR1A HTR7 SLC6A4
2 pyromania 11.0
3 uterus intravascular leiomyomatosis 10.6 HTR1A SLC6A4
4 meconium aspiration syndrome 10.6 HTR1A SMUG1
5 conjunctival pigmentation 10.6 HTR7 SLC6A4
6 anodontia 10.5 HTR1A SLC6A4
7 pompholyx 10.5 HTR1A SLC6A4
8 nodular ganglioneuroblastoma 10.5 CRP SMUG1
9 collagenopathy type 2 alpha 1 10.5 CRP IL6
10 abnormal pupillary function 10.5 HTR1A HTR7
11 crystal arthropathies 10.5 CRP IL6
12 dyserythropoietic anemia, congenital, type iii 10.5 CHRFAM7A CHRNA7
13 shoulder impingement syndrome 10.5 CRP IL6
14 brachydactyly-distal symphalangism syndrome 10.5 CRP IL6
15 neurogenic bladder 10.4 HTR7 SLC6A4
16 epstein-barr virus hepatitis 10.4 CRP IL6
17 x-linked dominant intellectual disability-epilepsy syndrome 10.4 CRP IL6
18 erythema elevatum diutinum 10.4 CRP IL6
19 anosognosia 10.4 CRP HTR1A SLC6A4
20 cataract congenital autosomal dominant 10.4 CRP IL6
21 chronic diarrhea due to guanylate cyclase 2c overactivity 10.4 CRP IL6
22 lymphocytic colitis 10.3 IL6 SLC6A4
23 conjunctival degeneration 10.3 HTR1A HTR7 SLC6A4
24 vallecula cancer 10.3 HTR1A IL6 SLC6A4
25 tinea pedis 10.3 HTR1A HTR7 SLC6A4
26 renpenning syndrome 10.3 HTR1A HTR7 SLC6A4
27 ornithosis 10.3 PRL SLC6A4
28 keratosis 10.3 HTR1A HTR7 SLC6A4
29 malignant gastric granular cell tumor 10.3 CRP IL6
30 hematocele of tunica vaginalis testis 10.3 HTR7 SLC6A4
31 placental abruption 10.2 ADRB1 CRP IL6
32 hepatitis d 10.2 HTR1A NPY SLC6A4
33 peroxisomal biogenesis disorders 10.2 ADRB1 PRL
34 central nervous system leiomyosarcoma 10.2 CRP IL6 SMUG1
35 euthyroid sick syndrome 10.2 CRP PRL
36 dermatitis herpetiformis, familial 10.2 CRP IL6 SMUG1
37 chronic dacryoadenitis 10.1 HTR1A PRL SLC6A4
38 nodular nonsuppurative panniculitis 10.1 CRP IL6
39 lung occult large cell carcinoma 10.1 CRP IL6
40 dyspepsia 10.1 NPY PRL
41 aicardi-goutieres syndrome 2 10.0 HTR1A PRL SLC6A4
42 hemangioma of spleen 10.0 CRP IL6
43 inherited metabolic disorder 10.0 CRP IL6 NPY
44 chromosome 11p13 deletion syndrome, distal 9.9 NPY PRL SLC6A4
45 colonic disease 9.9 CRP IL6 PRL
46 chronic conjunctivitis 9.9 CHRNA7 HTR1A PRL SLC6A4
47 partial motor epilepsy 9.8 HTR1A IL6 NPY SLC6A4
48 obsessive-compulsive personality disorder 9.8
49 avoidant personality disorder 9.8
50 eating disorder 9.8

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ADRB1 CGA CHRNA7 CRP GABRA2 HTR1A
2 nervous system MP:0003631 9.28 GABRA2 HTR1A HTR7 IL6 NPY PRL

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
3
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
4 Adrenergic Agents Phase 4
5 Adrenergic Agonists Phase 4
6 Adrenergic alpha-2 Receptor Agonists Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Antihypertensive Agents Phase 4
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
10
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
11 Serotonin Agents Phase 4,Phase 3,Phase 2
12 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
13 Serotonin 5-HT1 Receptor Agonists Phase 4
14
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
15
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
16 Antipsychotic Agents Phase 3
17 Central Nervous System Depressants Phase 3
18 Dopamine Agents Phase 3
19 Dopamine Antagonists Phase 3
20 Psychotropic Drugs Phase 3,Phase 2
21 Serotonin Antagonists Phase 3
22 Tranquilizing Agents Phase 3
23
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
24 Arginine Vasopressin Phase 1, Phase 2
25 Coagulants Phase 1, Phase 2
26 Hemostatics Phase 1, Phase 2
27 Hormones Phase 1, Phase 2
28 Natriuretic Agents Phase 1, Phase 2
29 SRX246 Phase 1, Phase 2
30 Vasopressins Phase 1, Phase 2
31 Antidepressive Agents Phase 2
32 Antidepressive Agents, Second-Generation Phase 2
33 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
34 Cytochrome P-450 Enzyme Inhibitors Phase 2
35 Neurotransmitter Uptake Inhibitors Phase 2
36 Serotonin Uptake Inhibitors Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Unknown status NCT02048241 Phase 4 Intuniv
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
3 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
4 Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
5 Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder Completed NCT02055638 Phase 1, Phase 2 SRX246;Placebo
6 A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder Completed NCT00078754 Phase 2 Fluoxetine;Divalproex;Placebo
7 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED Completed NCT00127400 Phase 2

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

39
Amygdala, Brain

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 85)
id Title Authors Year
1
A Wait-List Controlled Study of a Trauma-Focused Cognitive Behavioral Treatment for Intermittent Explosive Disorder in Timor-Leste. ( 28749158 )
2017
2
Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample. ( 28252880 )
2017
3
Intermittent explosive disorder and eating disorders: Analysis of national comorbidity and research samples. ( 28324677 )
2017
4
Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. ( 27693977 )
2016
5
Amygdala hyperactivation to angry faces in intermittent explosive disorder. ( 27145325 )
2016
6
Substance use disorders: Relationship with intermittent explosive disorder and with aggression, anger, and impulsivity. ( 27442963 )
2016
7
Defense styles in Intermittent Explosive Disorder. ( 27086223 )
2016
8
Prevalence of DSM-IV Intermittent Explosive Disorder in Black Adolescents: Findings From the National Survey of American Life, Adolescent Supplement. ( 27078052 )
2016
9
Social cognition in Intermittent Explosive Disorder and aggression. ( 27621104 )
2016
10
Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. ( 27624432 )
2016
11
Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). ( 28088746 )
2016
12
Negative urgency and reward/punishment sensitivity in intermittent explosive disorder. ( 27155024 )
2016
13
White Matter Integrity Reductions in Intermittent Explosive Disorder. ( 27206265 )
2016
14
The cross-national epidemiology of DSM-IV intermittent explosive disorder. ( 27572872 )
2016
15
Single Case Study: Neuropsychological Functioning in a Patient Diagnosed with Intermittent Explosive Disorder Pre and Post Neurosurgery. ( 27161981 )
2016
16
The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. ( 25754605 )
2015
17
Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. ( 25477263 )
2015
18
Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder. ( 26277033 )
2015
19
Emotion regulation deficits in intermittent explosive disorder. ( 27539871 )
2015
20
Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. ( 26105140 )
2015
21
The experience of aggressive outbursts in Intermittent Explosive Disorder. ( 25541537 )
2015
22
Verbal versus physical aggression in Intermittent Explosive Disorder. ( 25534757 )
2015
23
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. ( 24582164 )
2014
24
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. ( 24907536 )
2014
25
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. ( 24321204 )
2014
26
Intermittent Explosive Disorder and aversive parental care. ( 25064384 )
2014
27
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. ( 24760575 )
2014
28
History of childhood maltreatment in intermittent explosive disorder and suicidal behavior. ( 24935900 )
2014
29
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. ( 25106072 )
2014
30
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
31
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. ( 25300440 )
2014
32
Emotion regulation deficits in intermittent explosive disorder. ( 25403171 )
2014
33
Intermittent explosive disorder: a study in personalized psychopharmacotherapy. ( 24441311 )
2014
34
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. ( 23835102 )
2013
35
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. ( 23950885 )
2013
36
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. ( 24352431 )
2013
37
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. ( 23719736 )
2013
38
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. ( 22752056 )
2012
39
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. ( 22535310 )
2012
40
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. ( 22464337 )
2012
41
The prevalence and correlates of intermittent explosive disorder in Iraq. ( 22443168 )
2012
42
The relationship between childhood exposure to trauma and intermittent explosive disorder. ( 22464047 )
2012
43
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. ( 21295216 )
2011
44
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. ( 20709410 )
2011
45
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. ( 21786470 )
2011
46
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. ( 21812102 )
2011
47
Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. ( 20496987 )
2010
48
A family history study of intermittent explosive disorder. ( 20488459 )
2010
49
Latent structure of intermittent explosive disorder in an epidemiological sample. ( 20064645 )
2010
50
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. ( 19822329 )
2010

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for Intermittent Explosive Disorder

Pathways related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 ADRB1 CGA CHRNA7 GABRA2 HTR1A HTR7
2 11.82 ADRB1 CGA HTR7
3
Show member pathways
11.64 ADRB1 HTR1A HTR7
4 11.6 HTR1A HTR7 SLC6A4
5 11.41 CGA IL6 PRL
6 11.23 CHRFAM7A CHRNA7 HTR1A IL6 SLC6A4
7 11.06 ADRB1 CGA NPY
8 10.82 ADRB1 NPY
9 10.71 CRP IL6
10 10.58 HTR1A HTR7 SLC6A4

GO Terms for Intermittent Explosive Disorder

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.78 GOLPH3 HTR1A NPY PRL
2 positive regulation of gene expression GO:0010628 9.76 CRP CTSH IL6 SLC6A4
3 positive regulation of cell proliferation GO:0008284 9.72 CGA CHRNA7 CTSH HTR1A IL6
4 positive regulation of JAK-STAT cascade GO:0046427 9.43 IL6 PRL
5 behavior GO:0007610 9.4 HTR1A NPY
6 negative regulation of organ growth GO:0046621 9.37 CGA SLC6A4
7 negative regulation of lipid storage GO:0010888 9.26 CRP IL6
8 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.16 HTR1A HTR7
9 response to cold GO:0009409 8.96 ADRB1 IL6
10 vasoconstriction GO:0042310 8.8 HTR1A HTR7 SLC6A4

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 CGA NPY PRL
2 neurotransmitter receptor activity GO:0030594 9.32 HTR1A HTR7
3 G-protein coupled serotonin receptor activity GO:0004993 9.26 HTR1A HTR7
4 serotonin binding GO:0051378 8.96 HTR1A HTR7
5 extracellular ligand-gated ion channel activity GO:0005230 8.8 CHRFAM7A CHRNA7 GABRA2

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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