Intermittent Explosive Disorder disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Intermittent Explosive Disorder

Sources:
⁸Disease Ontology, ⁶³Wikipedia, ³²MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard

Disease Ontology:⁸ An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to borderline personality disorder and bipolar disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4), and among its related pathways are SIDS Susceptibility Pathways and Monoamine GPCRs. The compounds ondansetron and cabergoline have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia:⁶³ Intermittent explosive disorder (IED) is a behavioral disorder characterized by extreme expressions of... more...

Aliases & Classifications for Intermittent Explosive Disorder

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁶⁰UMLS, ⁵⁶SNOMED-CT, ²⁷ICD9CM, ³⁴MeSH
See all sources

Aliases & Descriptions:

intermittent explosive disorder ⁸ ¹⁰ ⁶⁰

explosive personality disorder ⁸ ⁶⁰

External Ids:

Disease Ontology⁸ DOID:12401

ICD9CM²⁷ 301.3, 312.34

SNOMED-CT⁵⁶ 40987004, 192488005, 268757006 192096007, 191759005, 231527003, more

MeSH³⁴ D007174

UMLS⁶⁰ C0021776, C0152183

Related Diseases for Intermittent Explosive Disorder

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)

id	Related Disease	Score	Top Affiliating Genes
1	borderline personality disorder	35.2	SLC6A4, CGA, HTR1B
2	bipolar disorder	35.2	CHRNA7, SLC6A4
3	personality disorder	35.2	SLC6A4, HTR1B
4	attention deficit hyperactivity disorder	13.3	SLC6A4, HTR1B
5	parkinson's disease	13.3	SLC6A4, CHRNA7, HTR1B
6	primary pulmonary hypertension	13.3	HTR1B, SLC6A4
7	autistic disorder	13.3	SLC6A4, CHRNA7
8	bulimia nervosa	13.3	HTR1B, SLC6A4
9	antisocial personality disorder	13.3	SLC6A4, HTR1B
10	obsessive-compulsive disorder	13.3	SLC6A4, HTR1B
11	conduct disorder	13.3	SLC6A4, CGA
12	schizoaffective disorder	13.3	SLC6A4, CHRNA7
13	down syndrome	13.3	CHRNA7, CGA
14	nicotine dependence	13.3	CHRNA7, SLC6A4
15	central nervous system disease	13.3	CHRNA7, SLC6A4
16	mood disorder	13.3	SLC6A4, HTR1B
17	pre-eclampsia	13.3	CGA, SLC6A4
18	psychotic disorder	13.3	SLC6A4, CHRNA7
19	prader-willi syndrome	10.2
20	physical disorder	10.2
21	premature ejaculation	10.0	SLC6A4
22	hypertension	10.0	SLC6A4
23	substance dependence	10.0	SLC6A4
24	anxiety disorder	10.0	SLC6A4
25	substance abuse	10.0	SLC6A4
26	alcohol abuse	10.0	SLC6A4
27	panic disorder	10.0	SLC6A4

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:

Clinical Features for Intermittent Explosive Disorder

Drugs & Therapeutics for Intermittent Explosive Disorder

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Intermittent Explosive Disorder

Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Search CenterWatch for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Intermittent Explosive Disorder:

³²

Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

Publications for Intermittent Explosive Disorder

Sources:
⁵⁰PubMed
See all sources

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 53)

id	Title	Authors	Year
1	Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. (24321204)	Coccaro E.F.... McCloskey M.S.	2014
2	Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)	Liddell B.J.... Steel Z.	2013
3	Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)	Coccaro E.F.... Coussons-Read M.	2013
4	Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)	Rees S.... Steel Z.	2013
5	Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. (23719736)	Anand S.	2013
6	The prevalence and correlates of intermittent explosive disorder in Iraq. (22443168)	Al-Hamzawi A.... McLaughlin K.A.	2012
7	Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)	McLaughlin K.A.... Kessler R.C.	2012
8	Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)	Perez-Rodriguez M.M.... New A.S.	2012
9	Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. (22535310)	Coccaro E.F.	2012
10	The relationship between childhood exposure to trauma and intermittent explosive disorder. (22464047)	Nickerson A.... Hofmann S.G.	2012
11	Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. (20709410)	Yoshimasu K.... Kawakami N.	2011
12	Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)		2011
13	Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)	Vu T.H.... Girirajan S.	2011
14	Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. (21295216)	Coccaro E.F.	2011
15	Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)	Ahmed A.O.... Berman M.E.	2010
16	A case of intermittent explosive disorder. (21694793)	Saha A.	2010
17	Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)	Dyer C.	2010
18	Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)	Coccaro E.F.... Kavoussi R.J.	2010
19	Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)	Murray-Close D.... Coccaro E.F.	2010
20	Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. (20496987)	McCloskey M.S.... Coccaro E.F.	2010
21	A family history study of intermittent explosive disorder. (20488459)	Coccaro E.F.	2010
22	Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)	Fincham D.... Myer L.	2009
23	A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)	Coccaro E.F.... Kavoussi R.J.	2009
24	The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)	McCloskey M.S.... Coccaro E.F.	2008
25	Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)	McCloskey M.S.... Coccaro E.F.	2008
26	Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)	Ortega A.N.... Alegria M.	2008
27	EEG correlates of moderate intermittent explosive disorder. (18032100)	Koelsch S.... Siebel W.A.	2008
28	Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)	McCloskey M.S.... Coccaro E.F.	2008
29	Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)	Berner J.E.	2007
30	Intermittent explosive disorder is common, has an early age of onset and is associated with the development of other mental disorders in the US population. (17255401)	Lara D.R.	2007
31	Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)	McCloskey M.S.... Coccaro E.F.	2006
32	Intermittent explosive disorder. (17131536)		2006
33	The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication. (16754840)	Kessler R.C.... Walters E.	2006
34	Prevalence and features of intermittent explosive disorder in a clinical setting. (16259534)	Coccaro E.F.... Zimmerman M.	2005
35	Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)	Coccaro E.F.	2004
36	Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)	Coccaro E.F.... Nestadt G.	2004
37	Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. (12900307)	Davanzo P.... McCracken J.	2003
38	Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)	Olvera R.L.	2002
39	Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)	Galovski T.... Blanchard E.B.	2002
40	Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)	Galovski T.... Veazey C.	2002
41	Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)	Olvera R.L.... Tripp R.F.	2001
42	Intermittent explosive disorder. (11122935)	Coccaro E.F.	2000
43	Recognition and treatment of DSM-IV intermittent explosive disorder. (10418808)	McElroy S.L.	1999
44	DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)	McElroy S.L.... Keck P.E.	1998
45	Intermittent explosive disorder-revised: development, reliability, and validity of research criteria. (9829145)	Coccaro E.F.... Lish J.D.	1998
46	Hypothalamic lesions and intermittent explosive disorder. (1627961)	Tonkonogy J.M.... Geller J.L.	1992
47	The diagnosis of intermittent explosive disorder in violent men. (2039850)	Felthous A.R.... Barratt E.	1991
48	Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)	Gupta B.K.... Yerevanian B.I.	1987
49	Therapeutic use of propranolol for intermittent explosive disorder. (3546964)	Jenkins S.C.... Maruta T.	1987
50	Metoprolol for intermittent explosive disorder. (4025634)	Mattes J.A.	1985

Genes related to Intermittent Explosive Disorder

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Intermittent Explosive Disorder:

id	Symbol	Products	Description	Score	Implication
1	SLC6A4		solute carrier family 6 (neurotransmitter transporter), member 4	19.68	GeneCards inferred : Publications (show sections)

Products for genes related to Intermittent Explosive Disorder disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	1	1	1
2	LSBio	-	-	1

Genetic Variations for Intermittent Explosive Disorder

Expression for genes affiliated with Intermittent Explosive Disorder

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

Sources:
³⁷NCBI BioSystems Database, ⁴⁹PharmGKB, ²⁹KEGG
See all sources

Pathways related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	SIDS Susceptibility Pathways³⁷	10.0	SLC6A4
2	Monoamine GPCRs³⁷ Hide members Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics⁴⁹	10.0	SLC6A4
3	Circadian entrainment²⁹ Hide members Serotonergic synapse²⁹	10.0	SLC6A4

Compounds for genes affiliated with Intermittent Explosive Disorder

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ¹¹DrugBank, ²⁴HMDB, ²⁸IUPHAR, ⁵⁹Tocris Bioscience
See all sources

Compounds related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

(show all 34)

id	Compound	Score	Top Affiliating Genes
1	ondansetron⁴⁴ ⁴⁹ ¹¹ ²⁴	13.8
2	cabergoline²⁸ ⁴⁴ ¹¹	12.8
3	bromocriptine²⁸ ⁴⁴ ¹¹	12.8
4	propranolol⁴⁴ ²⁸ ⁴⁹ ¹¹ ²⁴	14.7
5	dopamine⁴⁴ ²⁸ ¹¹ ²⁴	13.4	SLC6A4
6	clozapine⁴⁴ ²⁸ ⁴⁹ ¹¹	13.4	SLC6A4
7	lobeline⁴⁴	10.4	SLC6A4
8	5-hydroxytryptamine⁴⁴	10.3	SLC6A4
9	mcpp⁴⁴	10.3	SLC6A4
10	pindolol⁴⁴ ²⁸ ¹¹	12.3	SLC6A4
11	maoa⁴⁴	10.3	SLC6A4
12	fenfluramine²⁸ ⁴⁴ ¹¹	12.3	SLC6A4
13	venlafaxine⁴⁹ ⁴⁴ ¹¹ ²⁴	13.3	SLC6A4
14	ketanserin²⁸ ⁴⁴	11.3	SLC6A4
15	paroxetine⁴⁴ ⁴⁹ ²⁸ ¹¹	13.3	SLC6A4
16	risperidone²⁸ ⁴⁴ ⁴⁹ ⁵⁹ ¹¹ ²⁴	15.3	SLC6A4
17	aspartate⁴⁴	10.3	SLC6A4
18	fluoxetine⁴⁹ ⁴⁴ ²⁸ ¹¹	13.3	SLC6A4
19	mptp⁴⁴	10.3	SLC6A4
20	clonidine⁴⁴ ²⁸ ¹¹	12.3	SLC6A4
21	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	13.2	SLC6A4
22	opiate⁴⁴	10.2	SLC6A4
23	progestin⁴⁴	10.2	SLC6A4
24	amine⁴⁴	10.2	SLC6A4
25	glutamate⁴⁴	10.2	SLC6A4
26	alanine⁴⁴	10.2	SLC6A4
27	verapamil⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	14.1	SLC6A4
28	cocaine⁴⁴ ¹¹	11.1	SLC6A4
29	dihydrotestosterone⁴⁴ ²⁸ ¹¹ ²⁴	13.1	SLC6A4
30	choline⁴⁴ ¹¹ ²⁴	12.0	SLC6A4
31	carbon⁴⁴	10.0	SLC6A4
32	gaba⁴⁴	10.0	SLC6A4
33	nicotine⁴⁴ ⁴⁹ ²⁸ ¹¹	12.9	SLC6A4
34	gnrh⁴⁴	9.7	SLC6A4

GO Terms for genes affiliated with Intermittent Explosive Disorder

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of organ growth	GO:046621	10.0	SLC6A4
2	response to hypoxia	GO:001666	10.0	SLC6A4
3	vasoconstriction	GO:042310	9.9	SLC6A4
4	memory	GO:007613	9.7	SLC6A4