MCID: INT025
MIFTS: 39

Intermittent Explosive Disorder malady

Mental diseases category

Summaries for Intermittent Explosive Disorder

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and bipolar disorder. An important gene associated with Intermittent Explosive Disorder is HTR1B (5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and SIDS Susceptibility Pathways. The compounds mcpp and pindolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:66 Intermittent explosive disorder (IED) is a behavioral disorder characterized by extreme expressions of... more...

Aliases & Classifications for Intermittent Explosive Disorder

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

intermittent explosive disorder 9 11 63
explosive personality disorder 9 63


External Ids:

Disease Ontology9 DOID:12401
ICD9CM28 312.34, 301.3
MeSH36 D007174

Related Diseases for Intermittent Explosive Disorder

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to intermittent explosive disorder

Symptoms for Intermittent Explosive Disorder

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Drugs & Therapeutics for Intermittent Explosive Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Intermittent Explosive Disorder

Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Search CenterWatch for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

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Anatomical Context for Intermittent Explosive Disorder

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34MalaCards
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MalaCards organs/tissues related to Intermittent Explosive Disorder:

34
Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5CGA, HTR1B, CHRNA7
2MP:00053798.5CGA, SLC6A4, HTR1B

Publications for Intermittent Explosive Disorder

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53PubMed
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Articles related to Intermittent Explosive Disorder:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. (24321204)
2014
2
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)
2013
3
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)
2013
4
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)
2013
5
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. (23719736)
2013
6
The prevalence and correlates of intermittent explosive disorder in Iraq. (22443168)
2012
7
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)
2012
8
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)
2012
9
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. (22535310)
2012
10
The relationship between childhood exposure to trauma and intermittent explosive disorder. (22464047)
2012
11
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. (20709410)
2011
12
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)
2011
13
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)
2011
14
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. (21295216)
2011
15
Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)
2010
16
A case of intermittent explosive disorder. (21694793)
2010
17
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)
2010
18
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)
2010
19
Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. (20672913)
2010
20
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)
2010
21
Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. (20496987)
2010
22
Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)
2009
23
A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)
2009
24
P3a and mismatch negativity in individuals with moderate Intermittent Explosive Disorder. (19463896)
2009
25
The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)
2008
26
Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)
2008
27
Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)
2008
28
EEG correlates of moderate intermittent explosive disorder. (18032100)
2008
29
Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)
2008
30
Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)
2007
31
Intermittent explosive disorder is common, has an early age of onset and is associated with the development of other mental disorders in the US population. (17255401)
2007
32
Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)
2006
33
Intermittent explosive disorder. (17131536)
2006
34
The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication. (16754840)
2006
35
Prevalence and features of intermittent explosive disorder in a clinical setting. (16259534)
2005
36
Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)
2004
37
Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)
2004
38
Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. (12900307)
2003
39
Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)
2002
40
Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)
2002
41
Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)
2002
42
Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)
2001
43
Intermittent explosive disorder. (11122935)
2000
44
Recognition and treatment of DSM-IV intermittent explosive disorder. (10418808)
1999
45
DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)
1998
46
Hypothalamic lesions and intermittent explosive disorder. (1627961)
1992
47
The diagnosis of intermittent explosive disorder in violent men. (2039850)
1991
48
Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)
1987
49
Therapeutic use of propranolol for intermittent explosive disorder. (3546964)
1987
50
Metoprolol for intermittent explosive disorder. (4025634)
1985

Variations for Intermittent Explosive Disorder

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Expression for genes affiliated with Intermittent Explosive Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Compounds for genes affiliated with Intermittent Explosive Disorder

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1mcpp469.9SLC6A4, HTR1B
2pindolol46 30 1211.9SLC6A4, HTR1B
3nefazodone46 52 1211.9HTR1B, SLC6A4
4maoa469.9SLC6A4, HTR1B
5fenfluramine46 30 1211.9SLC6A4, HTR1B
6Serotonin259.8HTR1B, SLC6A4
7ketanserin46 3010.8HTR1B, SLC6A4
8clomipramine46 52 1211.8HTR1B, SLC6A4
9venlafaxine46 52 25 1212.8HTR1B, SLC6A4
10paroxetine46 52 30 1212.8SLC6A4, HTR1B
11quetiapine46 52 30 25 1213.8SLC6A4, HTR1B
12risperidone46 52 30 62 25 1214.8HTR1B, SLC6A4
13fluoxetine46 52 30 1212.8SLC6A4, HTR1B
14olanzapine46 52 30 25 1213.8SLC6A4, HTR1B
15lithium46 52 25 1212.8SLC6A4, HTR1B
16cabergoline46 30 1211.7CGA, HTR1B
17amine469.7SLC6A4, HTR1B
18bromocriptine46 30 1211.7CGA, HTR1B
19cocaine46 1210.7HTR1B, SLC6A4
20clonidine46 52 30 1212.7SLC6A4, CGA
21opiate469.7SLC6A4, CGA
22propranolol46 30 52 25 1213.7CGA, HTR1B
23progestin469.6CGA, SLC6A4
24verapamil46 30 52 25 1213.6CGA, SLC6A4
25dihydrotestosterone46 30 25 1212.6CGA, SLC6A4
26lobeline469.6SLC6A4, CHRNA7
27carbon469.6CGA, SLC6A4
28gnrh469.5CGA, SLC6A4
29mptp469.5SLC6A4, CHRNA7
30epinephrine46 25 1211.4SLC6A4, CGA
31choline46 25 1211.4SLC6A4, CHRNA7
32nicotine46 30 52 1212.3CHRNA7, SLC6A4
33tamoxifen46 52 30 1212.3CGA, SLC6A4
34gaba469.3SLC6A4, CHRNA7
35testosterone46 62 25 1212.2CGA, SLC6A4, HTR1B
36ondansetron52 46 25 1212.1SLC6A4, HTR1B, CHRNA7
37clozapine46 30 52 1212.0SLC6A4, HTR1B, CHRNA7
385-hydroxytryptamine469.0CHRNA7, HTR1B, SLC6A4
39nmda46 3010.0CHRNA7, SLC6A4
40norepinephrine46 25 1211.0CGA, SLC6A4
41acetylcholine46 52 30 25 1213.0CGA, CHRNA7
42aspartate468.9CHRNA7, SLC6A4, CGA
43glutamate468.8CHRNA7, SLC6A4, CGA
44alanine468.8CHRNA7, SLC6A4, CGA
45serine468.6CGA, SLC6A4, CHRNA7
46dopamine46 30 25 1211.4CHRNA7, HTR1B, SLC6A4, CGA

GO Terms for genes affiliated with Intermittent Explosive Disorder

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17Gene Ontology
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Cellular components related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.1SLC6A4, CHRNA7

Biological processes related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of organ growthGO:0466219.3CGA, SLC6A4
2vasoconstrictionGO:0423109.3SLC6A4, HTR1B
3response to hypoxiaGO:0016669.1SLC6A4, CHRNA7
4memoryGO:0076138.8SLC6A4, CHRNA7

Molecular functions related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1HTR1B, CHRNA7

Products for genes affiliated with Intermittent Explosive Disorder

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  • Antibodies
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Sources for Intermittent Explosive Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet