MCID: INT025
MIFTS: 40

Intermittent Explosive Disorder malady

Mental diseases category
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Summaries for Intermittent Explosive Disorder

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Disease Ontology:8 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and obsessive-compulsive disorder. An important gene associated with Intermittent Explosive Disorder is HTR1B (5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and SIDS Susceptibility Pathways. The compounds mcpp and pindolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:65 Intermittent explosive disorder (IED) is a behavioral disorder characterized by explosive outbursts of... more...

Aliases & Classifications for Intermittent Explosive Disorder

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Intermittent Explosive Disorder, Aliases & Descriptions:

Name: Intermittent Explosive Disorder 8 10 62
 
Explosive Personality Disorder 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:12401
ICD9CM27 312.34, 301.3
MeSH34 D007174

Related Diseases for Intermittent Explosive Disorder

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Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to intermittent explosive disorder

Symptoms for Intermittent Explosive Disorder

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Drugs & Therapeutics for Intermittent Explosive Disorder

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Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

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Anatomical Context for Intermittent Explosive Disorder

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MalaCards organs/tissues related to Intermittent Explosive Disorder:

32
Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

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MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5CGA, HTR1B, CHRNA7
2MP:00053798.5CGA, SLC6A4, HTR1B

Publications for Intermittent Explosive Disorder

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Articles related to Intermittent Explosive Disorder:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
2
Emotion regulation deficits in intermittent explosive disorder. (25403171)
2014
3
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. (25300440)
2014
4
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. (24907536)
2014
5
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. (25106072)
2014
6
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. (24760575)
2014
7
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. (24321204)
2014
8
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. (24582164)
2014
9
Intermittent Explosive Disorder and aversive parental care. (25064384)
2014
10
Intermittent explosive disorder: a study in personalized psychopharmacotherapy. (24441311)
2014
11
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)
2013
12
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)
2013
13
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)
2013
14
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. (23719736)
2013
15
The prevalence and correlates of intermittent explosive disorder in Iraq. (22443168)
2012
16
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)
2012
17
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)
2012
18
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. (22535310)
2012
19
Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. (20709410)
2011
20
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)
2011
21
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)
2011
22
Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)
2010
23
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)
2010
24
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)
2010
25
Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. (20672913)
2010
26
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)
2010
27
Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)
2009
28
A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)
2009
29
P3a and mismatch negativity in individuals with moderate Intermittent Explosive Disorder. (19463896)
2009
30
The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)
2008
31
Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)
2008
32
Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)
2008
33
EEG correlates of moderate intermittent explosive disorder. (18032100)
2008
34
Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)
2008
35
Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)
2007
36
Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)
2006
37
Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)
2004
38
Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)
2004
39
Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. (12900307)
2003
40
Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)
2002
41
Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)
2002
42
Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)
2002
43
Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)
2001
44
Intermittent explosive disorder. (11122935)
2000
45
DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)
1998
46
Hypothalamic lesions and intermittent explosive disorder. (1627961)
1992
47
The diagnosis of intermittent explosive disorder in violent men. (2039850)
1991
48
Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)
1987
49
Therapeutic use of propranolol for intermittent explosive disorder. (3546964)
1987
50
Metoprolol for intermittent explosive disorder. (4025634)
1985

Variations for Intermittent Explosive Disorder

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Expression for genes affiliated with Intermittent Explosive Disorder

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Expression patterns in normal tissues for genes affiliated with Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

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Compounds for genes affiliated with Intermittent Explosive Disorder

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Compounds related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1mcpp449.9SLC6A4, HTR1B
2pindolol44 28 1111.9SLC6A4, HTR1B
3nefazodone44 50 1111.9HTR1B, SLC6A4
4maoa449.9SLC6A4, HTR1B
5fenfluramine44 28 1111.9SLC6A4, HTR1B
6Serotonin249.8HTR1B, SLC6A4
7ketanserin44 2810.8HTR1B, SLC6A4
8clomipramine44 50 1111.8HTR1B, SLC6A4
9venlafaxine44 50 24 1112.8HTR1B, SLC6A4
10paroxetine44 50 28 1112.8SLC6A4, HTR1B
11quetiapine44 50 28 24 1113.8SLC6A4, HTR1B
12risperidone44 50 28 61 24 1114.8HTR1B, SLC6A4
13fluoxetine44 50 28 1112.8SLC6A4, HTR1B
14olanzapine44 50 28 24 1113.8SLC6A4, HTR1B
15lithium44 50 24 1112.8SLC6A4, HTR1B
16cabergoline44 28 1111.7CGA, HTR1B
17amine449.7SLC6A4, HTR1B
18bromocriptine44 28 1111.7CGA, HTR1B
19cocaine44 1110.7HTR1B, SLC6A4
20clonidine44 50 28 1112.7SLC6A4, CGA
21opiate449.7SLC6A4, CGA
22propranolol44 28 50 24 1113.7CGA, HTR1B
23progestin449.6CGA, SLC6A4
24verapamil44 28 50 24 1113.6CGA, SLC6A4
25dihydrotestosterone44 28 24 1112.6CGA, SLC6A4
26lobeline449.6SLC6A4, CHRNA7
27carbon449.6CGA, SLC6A4
28gnrh449.5CGA, SLC6A4
29mptp449.5SLC6A4, CHRNA7
30epinephrine44 24 1111.4SLC6A4, CGA
31choline44 24 1111.4SLC6A4, CHRNA7
32nicotine44 28 50 1112.3CHRNA7, SLC6A4
33tamoxifen44 50 28 1112.3CGA, SLC6A4
34gaba449.3SLC6A4, CHRNA7
35testosterone44 61 24 1112.2CGA, SLC6A4, HTR1B
36ondansetron50 44 24 1112.1SLC6A4, HTR1B, CHRNA7
37clozapine44 28 50 1112.0SLC6A4, HTR1B, CHRNA7
385-hydroxytryptamine449.0CHRNA7, HTR1B, SLC6A4
39nmda44 2810.0CHRNA7, SLC6A4
40norepinephrine44 24 1111.0CGA, SLC6A4
41acetylcholine44 50 28 24 1113.0CGA, CHRNA7
42aspartate448.9CHRNA7, SLC6A4, CGA
43glutamate448.8CHRNA7, SLC6A4, CGA
44alanine448.8CHRNA7, SLC6A4, CGA
45serine448.6CGA, SLC6A4, CHRNA7
46dopamine44 28 24 1111.4CHRNA7, HTR1B, SLC6A4, CGA

GO Terms for genes affiliated with Intermittent Explosive Disorder

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Cellular components related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.1SLC6A4, CHRNA7

Biological processes related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of organ growthGO:0466219.3CGA, SLC6A4
2vasoconstrictionGO:0423109.3SLC6A4, HTR1B
3response to hypoxiaGO:0016669.1SLC6A4, CHRNA7
4memoryGO:0076138.8SLC6A4, CHRNA7

Molecular functions related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1HTR1B, CHRNA7

Products for genes affiliated with Intermittent Explosive Disorder

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Sources for Intermittent Explosive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet