Intermittent Explosive Disorder disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Intermittent Explosive Disorder

Sources:
⁹Disease Ontology, ⁶⁴Wikipedia, ³²MalaCards
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Disease Ontology:⁹ An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and obsessive-compulsive disorder. An important gene associated with Intermittent Explosive Disorder is HTR1B (5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and SIDS Susceptibility Pathways. The compounds mcpp and pindolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:⁶⁴ Intermittent explosive disorder (IED) is a behavioral disorder characterized by explosive outbursts of... more...

Aliases & Classifications for Intermittent Explosive Disorder

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁶¹UMLS, ⁵⁶SNOMED-CT, ²⁸ICD9CM, ³⁴MeSH
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Intermittent Explosive Disorder, Aliases & Descriptions:

Name: Intermittent Explosive Disorder ⁹ ¹¹ ⁶¹

Explosive Personality Disorder ⁹ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases

External Ids:

Disease Ontology⁹ DOID:12401

ICD9CM²⁸ 312.34, 301.3

SNOMED-CT⁵⁶ 231527003, 268757006, 192488005 40987004, 191759005, 192096007, more

MeSH³⁴ D007174

UMLS⁶¹ C0021776, C0152183

Related Diseases for Intermittent Explosive Disorder

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
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Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 30)

id	Related Disease	Score	Top Affiliating Genes
1	personality disorder	31.0	SLC6A4, HTR1B
2	obsessive-compulsive disorder	30.6	HTR1B, SLC6A4
3	bipolar disorder	30.2	SLC6A4, CHRNA7
4	borderline personality disorder	30.2	HTR1B, SLC6A4, CGA
5	premature ejaculation	10.4	SLC6A4
6	substance abuse	10.4	SLC6A4
7	avoidant personality disorder	10.2
8	prader-willi syndrome	10.2
9	pyromania	10.2
10	obsessive-compulsive personality disorder	10.2
11	blindness	10.2
12	antisocial personality disorder	10.2	SLC6A4, HTR1B
13	bulimia nervosa	10.2	SLC6A4, HTR1B
14	attention deficit hyperactivity disorder	10.1	SLC6A4, HTR1B
15	conduct disorder	10.1	SLC6A4, CGA
16	pulmonary hypertension	10.1	SLC6A4, HTR1B
17	alcohol dependence	10.1	HTR1B, SLC6A4
18	migraine	10.1	HTR1B, SLC6A4
19	mood disorder	10.1	HTR1B, SLC6A4
20	schizoaffective disorder	10.0	SLC6A4, CHRNA7
21	nicotine dependence	10.0	CHRNA7, SLC6A4
22	central nervous system disease	10.0	SLC6A4, CHRNA7
23	psychotic disorder	10.0	SLC6A4, CHRNA7
24	pre-eclampsia	10.0	SLC6A4, CGA
25	autistic disorder	10.0	SLC6A4, CHRNA7
26	cholera	9.9	CGA, SLC6A4
27	down syndrome	9.8	CHRNA7, CGA
28	choriocarcinoma	9.8	CGA, SLC6A4
29	parkinson's disease	9.8	SLC6A4, HTR1B, CHRNA7
30	schizophrenia	9.8	SLC6A4, HTR1B, CHRNA7

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:

Symptoms for Intermittent Explosive Disorder

Drugs & Therapeutics for Intermittent Explosive Disorder

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

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³²MalaCards
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MalaCards organs/tissues related to Intermittent Explosive Disorder:

³²

Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	8.5	CGA, HTR1B, CHRNA7
2	endocrine/exocrine gland phenotype	MP:0005379	8.5	CGA, SLC6A4, HTR1B

Publications for Intermittent Explosive Disorder

Sources:
⁵¹PubMed
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Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 60)

id	Title	Authors	Year
1	Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)	Hebbar S.	2014
2	Emotion regulation deficits in intermittent explosive disorder. (25403171)	Fettich K.C.... Coccaro E.F.	2014
3	Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. (25300440)	Jenkins A.L.... Coccaro E.F.	2014
4	Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. (24907536)	Reardon A.F.... Miller M.W.	2014
5	Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. (25106072)	Moeller S.J.... Alia-Klein N.	2014
6	Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. (24760575)	Coccaro E.F.... McCloskey M.S.	2014
7	Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. (24321204)	Coccaro E.F.... McCloskey M.S.	2014
8	Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. (24582164)	Coccaro E.F.... Gozal D.	2014
9	Intermittent Explosive Disorder and aversive parental care. (25064384)	Lee R.... Coccaro E.F.	2014
10	Intermittent explosive disorder: a study in personalized psychopharmacotherapy. (24441311)	Leahy L.G.	2014
11	Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)	Liddell B.J.... Steel Z.	2013
12	Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)	Coccaro E.F.... Coussons-Read M.	2013
13	Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)	Rees S.... Steel Z.	2013
14	Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. (23719736)	Anand S.	2013
15	The prevalence and correlates of intermittent explosive disorder in Iraq. (22443168)	Al-Hamzawi A.... McLaughlin K.A.	2012
16	Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)	McLaughlin K.A.... Kessler R.C.	2012
17	Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)	Perez-Rodriguez M.M.... New A.S.	2012
18	Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. (22535310)	Coccaro E.F.	2012
19	Epidemiological aspects of intermittent explosive disorder in Japan; prevalence and psychosocial comorbidity: findings from the World Mental Health Japan Survey 2002-2006. (20709410)	Yoshimasu K.... Kawakami N.	2011
20	Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)		2011
21	Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)	Vu T.H.... Girirajan S.	2011
22	Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)	Ahmed A.O.... Berman M.E.	2010
23	Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)	Dyer C.	2010
24	Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)	Coccaro E.F.... Kavoussi R.J.	2010
25	Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. (20672913)	Maley J.H.... Richardson D.	2010
26	Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)	Murray-Close D.... Coccaro E.F.	2010
27	Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)	Fincham D.... Myer L.	2009
28	A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)	Coccaro E.F.... Kavoussi R.J.	2009
29	P3a and mismatch negativity in individuals with moderate Intermittent Explosive Disorder. (19463896)	Koelsch S.	2009
30	The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)	McCloskey M.S.... Coccaro E.F.	2008
31	Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)	McCloskey M.S.... Coccaro E.F.	2008
32	Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)	Ortega A.N.... Alegria M.	2008
33	EEG correlates of moderate intermittent explosive disorder. (18032100)	Koelsch S.... Siebel W.A.	2008
34	Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)	McCloskey M.S.... Coccaro E.F.	2008
35	Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)	Berner J.E.	2007
36	Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)	McCloskey M.S.... Coccaro E.F.	2006
37	Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)	Coccaro E.F.	2004
38	Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)	Coccaro E.F.... Nestadt G.	2004
39	Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. (12900307)	Davanzo P.... McCracken J.	2003
40	Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)	Olvera R.L.	2002
41	Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)	Galovski T.... Blanchard E.B.	2002
42	Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)	Galovski T.... Veazey C.	2002
43	Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)	Olvera R.L.... Tripp R.F.	2001
44	Intermittent explosive disorder. (11122935)	Coccaro E.F.	2000
45	DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)	McElroy S.L.... Keck P.E.	1998
46	Hypothalamic lesions and intermittent explosive disorder. (1627961)	Tonkonogy J.M.... Geller J.L.	1992
47	The diagnosis of intermittent explosive disorder in violent men. (2039850)	Felthous A.R.... Barratt E.	1991
48	Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)	Gupta B.K.... Yerevanian B.I.	1987
49	Therapeutic use of propranolol for intermittent explosive disorder. (3546964)	Jenkins S.C.... Maruta T.	1987
50	Metoprolol for intermittent explosive disorder. (4025634)	Mattes J.A.	1985

Genes related to Intermittent Explosive Disorder

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
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Genes related to Intermittent Explosive Disorder:

- Elite gene

id	Symbol	Description	Score	Implication
1	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	22.67	GeneCards inferred via : Disorders (show sections)
2	CGA	glycoprotein hormones, alpha polypeptide	17.67	GeneCards inferred via : Disorders (show sections)
3	CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	12.67	GeneCards inferred via : Disorders (show sections)
4	SLC6A4	solute carrier family 6 (neurotransmitter transporter), member 4	7.67	GeneCards inferred via : Publications (show sections)

Products for genes related to Intermittent Explosive Disorder disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	4	-	4	4
2	Novus Biologicals	4	4	4	-

Variations for Intermittent Explosive Disorder

Expression for genes affiliated with Intermittent Explosive Disorder

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

Sources:
⁴⁹PathCards, ⁵⁰PharmGKB, ³⁷NCBI BioSystems Database, ³⁰KEGG, ⁵⁴Reactome
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Pathways related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics⁵⁰	9.4	SLC6A4, HTR1B
2	SIDS Susceptibility Pathways³⁷	9.1	SLC6A4, CHRNA7
3	Circadian entrainment³⁰ Show member pathways Cholinergic synapse³⁰ GABAergic synapse³⁰ Serotonergic synapse³⁰ Retrograde endocannabinoid signaling³⁰ Dopaminergic synapse³⁰ Morphine addiction³⁰ Glutamatergic synapse³⁰	8.6	SLC6A4, HTR1B, CHRNA7
4	Peptide ligand-binding receptors⁵⁴ Show member pathways Vasopressin-like receptors⁵⁴ Relaxin receptors⁵⁴ Formyl peptide receptors bind formyl peptides and many other ligands⁵⁴ GPCRs, Class A Rhodopsin-like³⁷ Class A/1 (Rhodopsin-like receptors)⁵⁴ GPCR ligand binding⁵⁴ Neuroactive ligand-receptor interaction³⁰ G alpha (i) signalling events⁵⁴ Orexin and neuropeptides FF and QRFP bind to their respective receptors⁵⁴ Tachykinin receptors bind tachykinins⁵⁴	8.5	CHRNA7, HTR1B, CGA

Compounds for genes affiliated with Intermittent Explosive Disorder

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ¹²DrugBank, ⁵⁰PharmGKB, ²⁵HMDB, ⁶⁰Tocris Bioscience
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Compounds related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

(show all 46)

id	Compound	Score	Top Affiliating Genes
1	mcpp⁴⁴	9.9	SLC6A4, HTR1B
2	pindolol⁴⁴ ²⁹ ¹²	11.9	SLC6A4, HTR1B
3	nefazodone⁴⁴ ⁵⁰ ¹²	11.9	HTR1B, SLC6A4
4	maoa⁴⁴	9.9	SLC6A4, HTR1B
5	fenfluramine⁴⁴ ²⁹ ¹²	11.9	SLC6A4, HTR1B
6	Serotonin²⁵	9.8	HTR1B, SLC6A4
7	ketanserin⁴⁴ ²⁹	10.8	HTR1B, SLC6A4
8	clomipramine⁴⁴ ⁵⁰ ¹²	11.8	HTR1B, SLC6A4
9	venlafaxine⁴⁴ ⁵⁰ ²⁵ ¹²	12.8	HTR1B, SLC6A4
10	paroxetine⁴⁴ ⁵⁰ ²⁹ ¹²	12.8	SLC6A4, HTR1B
11	quetiapine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.8	SLC6A4, HTR1B
12	risperidone⁴⁴ ⁵⁰ ²⁹ ⁶⁰ ²⁵ ¹²	14.8	HTR1B, SLC6A4
13	fluoxetine⁴⁴ ⁵⁰ ²⁹ ¹²	12.8	SLC6A4, HTR1B
14	olanzapine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.8	SLC6A4, HTR1B
15	lithium⁴⁴ ⁵⁰ ²⁵ ¹²	12.8	SLC6A4, HTR1B
16	cabergoline⁴⁴ ²⁹ ¹²	11.7	CGA, HTR1B
17	amine⁴⁴	9.7	SLC6A4, HTR1B
18	bromocriptine⁴⁴ ²⁹ ¹²	11.7	CGA, HTR1B
19	cocaine⁴⁴ ¹²	10.7	HTR1B, SLC6A4
20	clonidine⁴⁴ ⁵⁰ ²⁹ ¹²	12.7	SLC6A4, CGA
21	opiate⁴⁴	9.7	SLC6A4, CGA
22	propranolol⁴⁴ ²⁹ ⁵⁰ ²⁵ ¹²	13.7	CGA, HTR1B
23	progestin⁴⁴	9.6	CGA, SLC6A4
24	verapamil⁴⁴ ²⁹ ⁵⁰ ²⁵ ¹²	13.6	CGA, SLC6A4
25	dihydrotestosterone⁴⁴ ²⁹ ²⁵ ¹²	12.6	CGA, SLC6A4
26	lobeline⁴⁴	9.6	SLC6A4, CHRNA7
27	carbon⁴⁴	9.6	CGA, SLC6A4
28	gnrh⁴⁴	9.5	CGA, SLC6A4
29	mptp⁴⁴	9.5	SLC6A4, CHRNA7
30	epinephrine⁴⁴ ²⁵ ¹²	11.4	SLC6A4, CGA
31	choline⁴⁴ ²⁵ ¹²	11.4	SLC6A4, CHRNA7
32	nicotine⁴⁴ ²⁹ ⁵⁰ ¹²	12.3	CHRNA7, SLC6A4
33	tamoxifen⁴⁴ ⁵⁰ ²⁹ ¹²	12.3	CGA, SLC6A4
34	gaba⁴⁴	9.3	SLC6A4, CHRNA7
35	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	12.2	CGA, SLC6A4, HTR1B
36	ondansetron⁵⁰ ⁴⁴ ²⁵ ¹²	12.1	SLC6A4, HTR1B, CHRNA7
37	clozapine⁴⁴ ²⁹ ⁵⁰ ¹²	12.0	SLC6A4, HTR1B, CHRNA7
38	5-hydroxytryptamine⁴⁴	9.0	CHRNA7, HTR1B, SLC6A4
39	nmda⁴⁴ ²⁹	10.0	CHRNA7, SLC6A4
40	norepinephrine⁴⁴ ²⁵ ¹²	11.0	CGA, SLC6A4
41	acetylcholine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.0	CGA, CHRNA7
42	aspartate⁴⁴	8.9	CHRNA7, SLC6A4, CGA
43	glutamate⁴⁴	8.8	CHRNA7, SLC6A4, CGA
44	alanine⁴⁴	8.8	CHRNA7, SLC6A4, CGA
45	serine⁴⁴	8.6	CGA, SLC6A4, CHRNA7
46	dopamine⁴⁴ ²⁹ ²⁵ ¹²	11.4	CHRNA7, HTR1B, SLC6A4, CGA

GO Terms for genes affiliated with Intermittent Explosive Disorder

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¹⁷Gene Ontology
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Cellular components related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:045121	9.1	SLC6A4, CHRNA7

Biological processes related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of organ growth	GO:046621	9.3	CGA, SLC6A4
2	vasoconstriction	GO:042310	9.3	SLC6A4, HTR1B
3	response to hypoxia	GO:001666	9.1	SLC6A4, CHRNA7
4	memory	GO:007613	8.8	SLC6A4, CHRNA7

Molecular functions related to Intermittent Explosive Disorder according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	drug binding	GO:008144	9.1	HTR1B, CHRNA7

Products for genes affiliated with Intermittent Explosive Disorder

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⁶³UniProtKB/Swiss-Prot

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MCID: INT025 MIFTS: 39	Intermittent Explosive Disorder malady Mental diseases category
4 genes, 1 tissue, 30 related diseases, clinical trials Download this MalaCard Expand all tables

Intermittent Explosive Disorder malady