MCID: INT025
MIFTS: 33

Intermittent Explosive Disorder malady

Aliases & Classifications for Intermittent Explosive Disorder

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Aliases & Descriptions for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 8 10 61
 
Explosive Personality Disorder 8 61


External Ids:

Disease Ontology8 DOID:12401
MeSH33 D007174
ICD9CM27 301.3, 312.34

Summaries for Intermittent Explosive Disorder

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Disease Ontology:8 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary: Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and obsessive-compulsive disorder. An important gene associated with Intermittent Explosive Disorder is HTR1B (5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and SIDS Susceptibility Pathways. The compounds mcpp and pindolol have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:64 Intermittent explosive disorder (IED) is a behavioral disorder characterized by explosive outbursts of... more...

Related Diseases for Intermittent Explosive Disorder

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Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to intermittent explosive disorder

Symptoms for Intermittent Explosive Disorder

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Drugs & Therapeutics for Intermittent Explosive Disorder

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Drug clinical trials:

Search ClinicalTrials for Intermittent Explosive Disorder

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

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Anatomical Context for Intermittent Explosive Disorder

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MalaCards organs/tissues related to Intermittent Explosive Disorder:

31
Brain

Animal Models for Intermittent Explosive Disorder or affiliated genes

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MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5CGA, HTR1B, CHRNA7
2MP:00053798.5CGA, SLC6A4, HTR1B

Publications for Intermittent Explosive Disorder

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Articles related to Intermittent Explosive Disorder:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Verbal versus physical aggression in Intermittent Explosive Disorder. (25534757)
2015
2
The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. (25754605)
2015
3
Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. (25477263)
2015
4
The experience of aggressive outbursts in Intermittent Explosive Disorder. (25541537)
2015
5
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
6
Emotion regulation deficits in intermittent explosive disorder. (25403171)
2014
7
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. (25300440)
2014
8
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. (24907536)
2014
9
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. (25106072)
2014
10
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. (24760575)
2014
11
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. (24321204)
2014
12
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. (24582164)
2014
13
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. (23835102)
2013
14
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. (24352431)
2013
15
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. (23950885)
2013
16
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. (22752056)
2012
17
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. (22464337)
2012
18
Treating intermittent explosive disorder. Emerging data show medication and cognitive behavioral therapy may help some patients. (21786470)
2011
19
Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder. (21812102)
2011
20
Latent structure of intermittent explosive disorder in an epidemiological sample. (20064645)
2010
21
A case of intermittent explosive disorder. (21694793)
2010
22
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears. (21147742)
2010
23
Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder. (19767013)
2010
24
Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. (20672913)
2010
25
Proactive, reactive, and romantic relational aggression in adulthood: measurement, predictive validity, gender differences, and association with Intermittent Explosive Disorder. (19822329)
2010
26
Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures. (19225243)
2009
27
A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. (19389333)
2009
28
P3a and mismatch negativity in individuals with moderate Intermittent Explosive Disorder. (19463896)
2009
29
The relationship between impulsive verbal aggression and intermittent explosive disorder. (17654692)
2008
30
Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial. (18837604)
2008
31
Lifetime and 12-month intermittent explosive disorder in Latinos. (18444735)
2008
32
EEG correlates of moderate intermittent explosive disorder. (18032100)
2008
33
Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder. (18221794)
2008
34
Intranasal ketamine for intermittent explosive disorder: a case report. (17854260)
2007
35
Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity. (16153657)
2006
36
Intermittent explosive disorder. (17131536)
2006
37
Intermittent explosive disorder and impulsive aggression: the time for serious study is now. (14738696)
2004
38
Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. (15291659)
2004
39
Intermittent explosive disorder: epidemiology, diagnosis and management. (12096933)
2002
40
Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. (12375724)
2002
41
Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. (12051483)
2002
42
Validation of the Interview Module for Intermittent Explosive Disorder (M-IED) in children and adolescents: a pilot study. (11311929)
2001
43
Intermittent explosive disorder. (11122935)
2000
44
Recognition and treatment of DSM-IV intermittent explosive disorder. (10418808)
1999
45
DSM-IV intermittent explosive disorder: a report of 27 cases. (9590677)
1998
46
Hypothalamic lesions and intermittent explosive disorder. (1627961)
1992
47
The diagnosis of intermittent explosive disorder in violent men. (2039850)
1991
48
Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient. (3667542)
1987
49
Therapeutic use of propranolol for intermittent explosive disorder. (3546964)
1987
50
Metoprolol for intermittent explosive disorder. (4025634)
1985

Variations for Intermittent Explosive Disorder

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Expression for genes affiliated with Intermittent Explosive Disorder

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Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for genes affiliated with Intermittent Explosive Disorder

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Compounds for genes affiliated with Intermittent Explosive Disorder

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Compounds related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1mcpp449.9HTR1B, SLC6A4
2pindolol44 28 1111.9HTR1B, SLC6A4
3nefazodone44 50 1111.9HTR1B, SLC6A4
4maoa449.9HTR1B, SLC6A4
5fenfluramine44 28 1111.9HTR1B, SLC6A4
6ketanserin44 2810.8HTR1B, SLC6A4
7Serotonin249.8HTR1B, SLC6A4
8venlafaxine44 50 24 1112.8SLC6A4, HTR1B
9clomipramine44 50 1111.8HTR1B, SLC6A4
10paroxetine44 50 28 1112.8HTR1B, SLC6A4
11quetiapine44 50 28 24 1113.8SLC6A4, HTR1B
12risperidone44 50 28 60 24 1114.8HTR1B, SLC6A4
13fluoxetine44 50 28 1112.8HTR1B, SLC6A4
14olanzapine44 50 28 24 1113.8HTR1B, SLC6A4
15lithium44 50 24 1112.8SLC6A4, HTR1B
16cabergoline44 28 1111.7HTR1B, CGA
17amine449.7SLC6A4, HTR1B
18bromocriptine44 28 1111.7HTR1B, CGA
19cocaine44 1110.7SLC6A4, HTR1B
20clonidine44 50 28 1112.7CGA, SLC6A4
21opiate449.7SLC6A4, CGA
22propranolol44 28 50 24 1113.7HTR1B, CGA
23progestin449.6SLC6A4, CGA
24verapamil44 28 50 24 1113.6CGA, SLC6A4
25dihydrotestosterone44 28 24 1112.6SLC6A4, CGA
26lobeline449.6CHRNA7, SLC6A4
27carbon449.6CGA, SLC6A4
28gnrh449.5CGA, SLC6A4
29mptp449.5CHRNA7, SLC6A4
30epinephrine44 24 1111.4CGA, SLC6A4
31choline44 24 1111.4CHRNA7, SLC6A4
32nicotine44 28 50 1112.3CHRNA7, SLC6A4
33tamoxifen44 50 28 1112.3SLC6A4, CGA
34gaba449.3SLC6A4, CHRNA7
35testosterone44 60 24 1112.2CGA, HTR1B, SLC6A4
36ondansetron50 44 24 1112.1HTR1B, SLC6A4, CHRNA7
37clozapine44 28 50 1112.0SLC6A4, CHRNA7, HTR1B
385-hydroxytryptamine449.0CHRNA7, SLC6A4, HTR1B
39nmda44 2810.0CHRNA7, SLC6A4
40norepinephrine44 24 1111.0CGA, SLC6A4
41acetylcholine44 50 28 24 1113.0CGA, CHRNA7
42aspartate448.9CHRNA7, SLC6A4, CGA
43glutamate448.8CHRNA7, CGA, SLC6A4
44alanine448.8CHRNA7, SLC6A4, CGA
45serine448.6CHRNA7, SLC6A4, CGA
46dopamine44 28 24 1111.4SLC6A4, CGA, CHRNA7, HTR1B

GO Terms for genes affiliated with Intermittent Explosive Disorder

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Cellular components related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451219.1SLC6A4, CHRNA7

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of organ growthGO:00466219.3CGA, SLC6A4
2vasoconstrictionGO:00423109.3SLC6A4, HTR1B
3response to hypoxiaGO:00016669.1SLC6A4, CHRNA7
4memoryGO:00076138.8SLC6A4, CHRNA7

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00081449.1HTR1B, CHRNA7

Sources for Intermittent Explosive Disorder

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet