MCID: INT059
MIFTS: 28

Internal Hemorrhoid malady

Cardiovascular diseases category

Summaries for Internal Hemorrhoid

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MalaCards based summary: Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and portal hypertension. An important gene associated with Internal Hemorrhoid is MMP9 (matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)), and among its related pathways are Pathways in cancer and Toll-like receptor signaling pathway. The compounds minocycline and ciglitazone have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Internal Hemorrhoid

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Internal Hemorrhoid, Aliases & Descriptions:

Name: Internal Hemorrhoid 10
 
Internal Hemorrhoids 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:9749
ICD9CM29 455.6
SNOMED-CT57 82985000
ICD1027 I84.1, I84.2

Related Diseases for Internal Hemorrhoid

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Diseases in the Hemorrhoid family:

internal hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhoid10.6
2portal hypertension10.1
3collagenous colitis10.0NOS2
4hypertension, essential10.0MMP9
5vascular disease10.0NOS2, MMP9
6osteoarthritis10.0MMP9, NOS2
7multiple sclerosis, disease progression, modifier of10.0NOS2, MMP9
8astrocytoma10.0MMP9, NOS2
9arthritis10.0MMP9, NOS2
10glioblastoma10.0NOS2, MMP9
11asthma10.0NOS2, MMP9
12atherosclerosis10.0NOS2, MMP9
13breast cancer10.0MMP9, NOS2
14malignant glioma10.0MMP9, NOS2
15rheumatoid arthritis10.0MMP9, NOS2
16adenocarcinoma10.0NOS2, MMP9
17colorectal cancer10.0MMP9, NOS2
18tongue squamous cell carcinoma10.0NOS2, MMP9

Graphical network of diseases related to Internal Hemorrhoid:



Diseases related to internal hemorrhoid

Symptoms for Internal Hemorrhoid

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Drugs & Therapeutics for Internal Hemorrhoid

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Drug clinical trials:

Search ClinicalTrials for Internal Hemorrhoid

Search NIH Clinical Center for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

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Anatomical Context for Internal Hemorrhoid

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MalaCards organs/tissues related to Internal Hemorrhoid:

33
Liver

Animal Models for Internal Hemorrhoid or affiliated genes

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MGI Mouse Phenotypes related to Internal Hemorrhoid:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1NOS2, MMP9
2MP:00020068.8NOS2, MMP9

Publications for Internal Hemorrhoid

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Articles related to Internal Hemorrhoid:

idTitleAuthorsYear
1
Pyogenic liver abscess as a complication of internal hemorrhoid banding. (24480193)
2014
2
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. (23089912)
2012
3
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. (21633644)
2011
4
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. (17665254)
2007
5
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. (17115317)
2006
6
Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. (16149003)
2005
7
Internal hemorrhoid bleeding in patients with portal hypertension. (3498664)
1987
8
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. (18737501)
1918

Variations for Internal Hemorrhoid

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Expression for genes affiliated with Internal Hemorrhoid

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Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for genes affiliated with Internal Hemorrhoid

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Pathways related to Internal Hemorrhoid according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1NOS2, MMP9
2
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1NOS2, MMP9
39.1NOS2, MMP9
49.1NOS2, MMP9

Compounds for genes affiliated with Internal Hemorrhoid

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Compounds related to Internal Hemorrhoid according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1minocycline45 1310.5NOS2, MMP9
2ciglitazone45 3010.5NOS2, MMP9
3parthenolide45 310.5NOS2, MMP9
4ns 39845 6110.5MMP9, NOS2
5alpha lipoic acid459.5NOS2, MMP9
6silymarin459.5NOS2, MMP9
7l-nmma459.5MMP9, NOS2
8fluvastatin45 51 30 1312.5NOS2, MMP9
9celecoxib45 61 30 51 26 1314.5NOS2, MMP9
10pdtc459.4NOS2, MMP9
11resveratrol45 61 26 1312.4MMP9, NOS2
12egcg459.4NOS2, MMP9
13herbimycin a45 6110.4NOS2, MMP9
14curcumin459.4MMP9, NOS2
15n acetylcysteine459.4NOS2, MMP9
16sb 20358045 6110.4NOS2, MMP9
17ly294002459.4MMP9, NOS2
18actinomycin d459.3NOS2, MMP9
19genistein45 30 61 3 26 1314.3NOS2, MMP9
20pge2459.3MMP9, NOS2
21adenylate459.2NOS2, MMP9
22cycloheximide459.2NOS2, MMP9
23dexamethasone45 51 30 1312.1MMP9, NOS2
24estrogen459.1NOS2, MMP9
25vegf459.0NOS2, MMP9
26glutamate458.8NOS2, MMP9

GO Terms for genes affiliated with Internal Hemorrhoid

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Products for genes affiliated with Internal Hemorrhoid

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Internal Hemorrhoid

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet