MCID: INT059
MIFTS: 36

Internal Hemorrhoid

Categories: Cardiovascular diseases

Aliases & Classifications for Internal Hemorrhoid

MalaCards integrated aliases for Internal Hemorrhoid:

Name: Internal Hemorrhoid 12 14
Internal Hemorrhoids 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9749
ICD9CM 35 455.6
SNOMED-CT 64 82985000
ICD10 33 I84.1 I84.2
UMLS 69 C0041844

Summaries for Internal Hemorrhoid

MalaCards based summary : Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and emphysematous cholecystitis. An important gene associated with Internal Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Internal Hemorrhoid

Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
id Related Disease Score Top Affiliating Genes
1 hemorrhoid 11.3
2 emphysematous cholecystitis 10.6 MMP9 NOS2
3 brain ischemia 10.6 MMP7 MMP9
4 immunodeficiency 27b, mycobacteriosis, ad 10.6 MMP7 MMP9
5 hemoglobin lepore-beta-thalassemia syndrome 10.5 MMP1 MMP9
6 mycobacterium gordonae 10.5 MMP9 NOS2
7 pellagra like syndrome 10.5 MMP7 MMP9
8 congenital chloride diarrhea 10.5 MMP1 NOS2
9 ectropion 10.5 MMP1 MMP9
10 lacrimal gland squamous cell carcinoma 10.5 CD34 MMP9
11 facial arteriovenous malformation 10.5 MMP2 MMP9
12 leucocyte adhesion defect 10.5 MMP2 MMP9
13 acquired hemangioma 10.5 MMP2 MMP9
14 drug rash with eosinophilia and systemic symptoms 10.5 MMP2 MMP9
15 collagenous colitis 10.5 MMP2 MMP9
16 sialadenitis 10.5 MMP2 MMP9
17 cecum adenoma 10.4 MMP2 MMP9
18 corneal staphyloma 10.4 MMP2 MMP9
19 lipoid nephrosis 10.4 MMP1 MMP9
20 spindle epithelial tumor with thymus-like differentiation tumor 10.4 MMP2 MMP9
21 nasal cavity adenocarcinoma 10.4 MMP2 MMP9
22 ulnar neuropathy 10.4 MMP2 MMP9
23 charcot-marie-tooth disease, axonal, type 2cc 10.4 MMP2 MMP9
24 colon squamous cell carcinoma 10.4 MMP2 MMP9
25 influenza 10.4 MMP2 MMP9
26 acquired thrombocytopenia 10.4 MMP1 NOS2
27 myopathy 10.4 MMP1 MMP9
28 tricho onychic dysplasia 10.4 MMP2 MMP9
29 lung papillary adenocarcinoma 10.4 MMP2 MMP9
30 liver lymphoma 10.3 MMP1 MMP2
31 gait apraxia 10.3 MMP1 MMP2
32 thymus clear cell carcinoma 10.2 MMP2 MMP7
33 corpus callosum agenesis of blepharophimosis robin type 10.2 MMP1 MMP7
34 cystitis 10.2 MMP2 MMP9
35 pulmonary sarcoidosis 10.2 MMP1 MMP9
36 skin amelanotic melanoma 10.2 MMP1 MMP2
37 early myoclonic encephalopathy 10.2 MMP1 MMP7 MMP9
38 bleeding disorder, platelet-type, 21 10.2 MMP1 MMP2
39 familial short qt syndrome 10.1 MMP2 MMP7 MMP9
40 tinea profunda 10.1 MMP2 MMP7 MMP9
41 polyneuropathy in collagen vascular disease 10.1 HSPA4 MMP9
42 intra-abdominal lymph node mast cell malignancy 10.1 MMP1 MMP9
43 retroperitoneal sarcoma 10.1 CASP3 NOS2
44 diamond-blackfan anemia 3 10.1 MMP1 MMP7 MMP9
45 spinal stenosis 10.1 CASP3 MMP9 NOS2
46 adenosine monophosphate deaminase 1 deficiency 10.1 MMP1 MMP2 MMP9
47 oligomeganephronic renal hypoplasia 10.1 MMP1 MMP2 MMP9
48 rare endometriosis 10.1 MMP1 MMP2 MMP9
49 laryngostenosis 10.1 MMP1 MMP2 MMP9
50 mastoiditis 10.0 MMP1 MMP2 MMP9

Graphical network of the top 20 diseases related to Internal Hemorrhoid:



Diseases related to Internal Hemorrhoid

Symptoms & Phenotypes for Internal Hemorrhoid

MGI Mouse Phenotypes related to Internal Hemorrhoid:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 MMP9 NOS2 ACE2 CASP3 CD34 MMP1
2 immune system MP:0005387 9.92 ACE2 CASP3 CD34 MMP1 MMP2 MMP7
3 cardiovascular system MP:0005385 9.91 ACE2 CASP3 MMP2 MMP7 MMP9 NOS2
4 digestive/alimentary MP:0005381 9.8 ACE2 CASP3 MMP7 MMP9 NOS2
5 muscle MP:0005369 9.65 ACE2 CASP3 MMP2 MMP9 NOS2
6 neoplasm MP:0002006 9.63 CD34 MMP1 MMP2 MMP7 MMP9 NOS2
7 respiratory system MP:0005388 9.35 ACE2 CASP3 MMP2 MMP9 NOS2
8 vision/eye MP:0005391 9.02 CASP3 MMP2 MMP7 MMP9 NOS2

Drugs & Therapeutics for Internal Hemorrhoid

Drugs for Internal Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Botulinum Toxins Phase 4
4 Botulinum Toxins, Type A Phase 4
5 Cholinergic Agents Phase 4
6 Neurotransmitter Agents Phase 4
7 onabotulinumtoxinA Phase 4
8 Pharmaceutical Solutions Phase 4
9
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
10
Prilocaine Approved Phase 3 721-50-6 4906
11 Anesthetics Phase 3
12 Anesthetics, Local Phase 3
13 Anti-Arrhythmia Agents Phase 3
14 Central Nervous System Depressants Phase 3
15 Diuretics, Potassium Sparing Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Sodium Channel Blockers Phase 3
18
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
19
Butyric Acid Experimental Phase 2 107-92-6 264
20 Anti-Inflammatory Agents Phase 2
21 Cortisol succinate Phase 2
22 Hydrocortisone 17-butyrate 21-propionate Phase 2
23 Hydrocortisone acetate Phase 2
24 Hydrocortisone-17-butyrate Phase 2
25
Trimebutine Approved 39133-31-8
26 Autonomic Agents
27 Gastrointestinal Agents
28 Parasympatholytics

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Pain Relief for Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
2 Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
3 Study About Patient Comfort and Long-term Outcome After Stapled Hemorrhoidopexy Completed NCT01533363 Phase 3
4 Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
5 Safety and Efficacy Study of Anucort HC TM 25mg Rectal Suppositories to Treat Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
6 Comparison Between Single and Triple Rubber Band Ligation for the Treatment of Hemorrhoids Unknown status NCT01383577
7 A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421
8 The Relationship Between Haemorrhoids and Pelvic Vein Reflux Unknown status NCT02039570
9 Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe Completed NCT00630669
10 Safety and Efficacy Study of HET Bipolar System for Treatment of Stage I and Stage II Hemorrhoids Completed NCT01841970
11 Multicenter Prospective Trial on Hemorrhoids Recruiting NCT03245086
12 HET Bipolar System: Validation of Outpatient Hemorrhoid Treatment Active, not recruiting NCT02773420
13 Effect of Topical Trimebutine on Pain After Hemorrhoidectomy Suspended NCT03036111 Trimebutine
14 Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD) Terminated NCT01199679

Search NIH Clinical Center for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

Anatomical Context for Internal Hemorrhoid

MalaCards organs/tissues related to Internal Hemorrhoid:

39
Liver

Publications for Internal Hemorrhoid

Articles related to Internal Hemorrhoid:

id Title Authors Year
1
Rectal arterio-venous malformation (AVM) with bleeding of an internal hemorrhoid. ( 26879656 )
2016
2
Pyogenic liver abscess as a complication of internal hemorrhoid banding. ( 24480193 )
2014
3
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. ( 23089912 )
2012
4
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. ( 21633644 )
2011
5
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. ( 17665254 )
2007
6
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. ( 17115317 )
2006
7
[Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. ( 16149003 )
2005
8
Internal hemorrhoid bleeding in patients with portal hypertension. ( 3498664 )
1987
9
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. ( 18737501 )
1918

Variations for Internal Hemorrhoid

Expression for Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for Internal Hemorrhoid

Pathways related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CASP3 MMP1 MMP2 MMP7 MMP9
2
Show member pathways
13.11 CASP3 MMP1 MMP2 MMP9 NOS2
3
Show member pathways
12.56 CASP3 MMP1 MMP2 MMP7 MMP9
4 12.45 CASP3 MMP1 MMP2 MMP9 NOS2
5
Show member pathways
12.11 CASP3 MMP1 MMP9
6 12.07 CASP3 MMP2 MMP9
7 11.82 CASP3 MMP9 NOS2
8 11.76 MMP1 MMP2 MMP9 NOS2
9 11.67 MMP2 MMP7 MMP9
10
Show member pathways
11.66 MMP1 MMP2 MMP7 MMP9
11 11.59 MMP1 MMP2 MMP9
12 11.53 CASP3 MMP2 MMP9
13 11.41 CASP3 MMP1 NOS2
14
Show member pathways
11.36 MMP1 MMP2 MMP9 NOS2
15 11.32 MMP2 MMP9
16 11.32 CASP3 MMP1 MMP2 MMP7 MMP9 NOS2
17 11.3 CASP3 MMP1
18
Show member pathways
11.28 MMP2 MMP9
19 11.24 MMP1 MMP2 MMP7 MMP9
20 11.21 MMP1 MMP9
21 11.2 MMP1 MMP2 MMP9
22 11.2 ACE2 MMP2 MMP9
23 11.17 CASP3 MMP2 MMP7 MMP9 NOS2
24 11.13 CASP3 MMP2
25 11.02 ACE2 MMP2 MMP9
26 11 MMP2 MMP9
27 10.9 MMP1 MMP2
28 10.73 MMP1 MMP7 MMP9

GO Terms for Internal Hemorrhoid

Cellular components related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ACE2 CD34 MMP1 MMP2 MMP7 MMP9
2 proteinaceous extracellular matrix GO:0005578 9.26 MMP1 MMP2 MMP7 MMP9
3 extracellular matrix GO:0031012 8.92 MMP1 MMP2 MMP7 MMP9

Biological processes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.63 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 leukocyte migration GO:0050900 9.58 CD34 MMP1 MMP9
3 embryo implantation GO:0007566 9.43 MMP2 MMP9
4 response to hypoxia GO:0001666 9.43 CASP3 MMP2 NOS2
5 endodermal cell differentiation GO:0035987 9.37 MMP2 MMP9
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.32 MMP2 MMP9
7 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP2 MMP7 MMP9
8 collagen catabolic process GO:0030574 8.92 MMP1 MMP2 MMP7 MMP9

Molecular functions related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.88 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 zinc ion binding GO:0008270 9.77 ACE2 MMP1 MMP2 MMP7 MMP9
3 serine-type endopeptidase activity GO:0004252 9.56 MMP1 MMP2 MMP7 MMP9
4 endopeptidase activity GO:0004175 9.5 ACE2 MMP1 MMP9
5 metalloendopeptidase activity GO:0004222 9.46 MMP1 MMP2 MMP7 MMP9
6 peptidase activity GO:0008233 9.43 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
7 metallopeptidase activity GO:0008237 9.02 ACE2 MMP1 MMP2 MMP7 MMP9

Sources for Internal Hemorrhoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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