MCID: INT059
MIFTS: 24

Internal Hemorrhoid malady

Cardiovascular diseases category

Summaries for Internal Hemorrhoid

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32MalaCards
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MalaCards: Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and portal hypertension. An important gene associated with Internal Hemorrhoid is MMP9 (matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)), and among its related pathways are Pathways in cancer and Toll-like receptor signaling pathway. The compounds minocycline and ciglitazone have been mentioned in the context of this disorder.

Aliases & Classifications for Internal Hemorrhoid

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Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Related Diseases for Internal Hemorrhoid

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17GeneCards, 18GeneDecks
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Diseases in the Hemorrhoid family:

internal hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 20)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhoid10.5
2portal hypertension10.1
3hypertension10.1
4collagenous colitis10.0NOS2
5gastrointestinal system disease10.0NOS2
6myocarditis10.0NOS2
7hypercholesterolemia10.0NOS2
8diabetic retinopathy10.0NOS2
9encephalomyelitis10.0NOS2
10gastritis10.0NOS2
11cholesteatoma10.0MMP9
12glomerulonephritis10.0NOS2
13vascular disease10.0NOS2
14kawasaki disease10.0MMP9
15abdominal aortic aneurysm10.0MMP9
16hyperglycemia10.0NOS2
17fibrosarcoma10.0MMP9
18meningitis10.0MMP9
19pulmonary fibrosis10.0MMP9
20pulmonary disease, chronic obstructive10.0MMP9

Graphical network of diseases related to Internal Hemorrhoid:



Diseases related to internal hemorrhoid

Clinical Features for Internal Hemorrhoid

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Drugs & Therapeutics for Internal Hemorrhoid

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Internal Hemorrhoid

Drug clinical trials:

Search ClinicalTrials for Internal Hemorrhoid

Search NIH Clinical Center for Internal Hemorrhoid

Search CenterWatch for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

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Anatomical Context for Internal Hemorrhoid

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Animal Models for Internal Hemorrhoid or affiliated genes

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Publications for Internal Hemorrhoid

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50PubMed
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Articles related to Internal Hemorrhoid:

idTitleAuthorsYear
1
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. (23089912)
2012
2
PPH-01 versus PPH-03 to perform STARR for the treatment of hemorrhoids associated with large internal rectal prolapse: a prospective multicenter randomized trial. (21737467)
2011
3
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. (21633644)
2011
4
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. (17665254)
2007
5
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. (17115317)
2006
6
Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. (16149003)
2005
7
Internal hemorrhoid bleeding in patients with portal hypertension. (3498664)
1987
8
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. (18737501)
1918

Genetic Variations for Internal Hemorrhoid

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Expression for genes affiliated with Internal Hemorrhoid

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for genes affiliated with Internal Hemorrhoid

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Internal Hemorrhoid according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1NOS2, MMP9
2
Hide members
9.1NOS2, MMP9
39.1NOS2, MMP9
49.1NOS2, MMP9

Compounds for genes affiliated with Internal Hemorrhoid

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Internal Hemorrhoid according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1minocycline44 1110.5NOS2, MMP9
2ciglitazone44 2810.5MMP9, NOS2
3parthenolide44 210.5MMP9, NOS2
4ns 39844 5910.4NOS2, MMP9
5silymarin449.4MMP9, NOS2
6alpha lipoic acid449.4MMP9, NOS2
7l-nmma449.4NOS2, MMP9
8fluvastatin44 49 28 1112.4MMP9, NOS2
9celecoxib44 59 28 49 11 2414.4NOS2, MMP9
10pdtc449.4NOS2, MMP9
11resveratrol44 59 11 2412.4MMP9, NOS2
12egcg449.3NOS2, MMP9
13herbimycin a44 5910.3NOS2, MMP9
14curcumin449.3MMP9, NOS2
15n acetylcysteine449.2NOS2, MMP9
16sb 20358044 5910.2MMP9, NOS2
17ly294002449.1NOS2, MMP9
18pge2449.1NOS2, MMP9
19actinomycin d449.0NOS2, MMP9
20genistein44 28 59 2 11 2413.8NOS2, MMP9

GO Terms for genes affiliated with Internal Hemorrhoid

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Products for genes affiliated with Internal Hemorrhoid

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Internal Hemorrhoid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet