MCID: INT059
MIFTS: 27

Internal Hemorrhoid malady

Cardiovascular diseases category

Summaries for Internal Hemorrhoid

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34MalaCards
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MalaCards: Internal Hemorrhoid, also known as internal hemorrhoids, is related to hypertension and hemorrhoid. An important gene associated with Internal Hemorrhoid is MMP9 (matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)), and among its related pathways are Pathways in cancer and Toll-like receptor signaling pathway. The compounds minocycline and ciglitazone have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Internal Hemorrhoid

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Related Diseases for Internal Hemorrhoid

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Hemorrhoid family:

internal hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.3MMP9
2hemorrhoid10.5
3portal hypertension10.1
4collagenous colitis10.1NOS2
5vascular disease10.0NOS2, MMP9
6osteoarthritis10.0NOS2, MMP9
7multiple sclerosis10.0NOS2, MMP9
8astrocytoma10.0NOS2, MMP9
9arthritis10.0MMP9, NOS2
10glioblastoma multiforme10.0NOS2, MMP9
11asthma10.0NOS2, MMP9
12atherosclerosis10.0MMP9, NOS2
13breast cancer10.0NOS2, MMP9
14malignant glioma10.0MMP9, NOS2
15rheumatoid arthritis10.0NOS2, MMP9
16adenocarcinoma10.0NOS2, MMP9
17colon cancer10.0NOS2, MMP9
18tongue squamous cell carcinoma9.9NOS2, MMP9

Graphical network of diseases related to Internal Hemorrhoid:



Diseases related to internal hemorrhoid

Symptoms for Internal Hemorrhoid

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Drugs & Therapeutics for Internal Hemorrhoid

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Internal Hemorrhoid

Drug clinical trials:

Search ClinicalTrials for Internal Hemorrhoid

Search NIH Clinical Center for Internal Hemorrhoid

Search CenterWatch for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

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Anatomical Context for Internal Hemorrhoid

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Animal Models for Internal Hemorrhoid or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Internal Hemorrhoid:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1NOS2, MMP9
2MP:00020068.8NOS2, MMP9

Publications for Internal Hemorrhoid

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53PubMed
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Articles related to Internal Hemorrhoid:

idTitleAuthorsYear
1
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. (23089912)
2012
2
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. (21633644)
2011
3
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. (17665254)
2007
4
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. (17115317)
2006
5
Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. (16149003)
2005
6
Internal hemorrhoid bleeding in patients with portal hypertension. (3498664)
1987
7
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. (18737501)
1918

Variations for Internal Hemorrhoid

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Expression for genes affiliated with Internal Hemorrhoid

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for genes affiliated with Internal Hemorrhoid

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database
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Pathways related to Internal Hemorrhoid according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1NOS2, MMP9
2
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1NOS2, MMP9
39.1NOS2, MMP9
49.1NOS2, MMP9

Compounds for genes affiliated with Internal Hemorrhoid

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 3BitterDB, 62Tocris Bioscience, 52PharmGKB, 25HMDB
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Compounds related to Internal Hemorrhoid according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1minocycline46 1210.5NOS2, MMP9
2ciglitazone46 3010.5NOS2, MMP9
3parthenolide46 310.5NOS2, MMP9
4ns 39846 6210.5MMP9, NOS2
5alpha lipoic acid469.5NOS2, MMP9
6silymarin469.5NOS2, MMP9
7l-nmma469.5MMP9, NOS2
8fluvastatin46 52 30 1212.5NOS2, MMP9
9celecoxib46 62 30 52 25 1214.5NOS2, MMP9
10pdtc469.4NOS2, MMP9
11resveratrol46 62 25 1212.4MMP9, NOS2
12egcg469.4NOS2, MMP9
13herbimycin a46 6210.4NOS2, MMP9
14curcumin469.4MMP9, NOS2
15n acetylcysteine469.4NOS2, MMP9
16sb 20358046 6210.4NOS2, MMP9
17ly294002469.4MMP9, NOS2
18actinomycin d469.3NOS2, MMP9
19genistein46 30 62 3 25 1214.3NOS2, MMP9
20pge2469.3MMP9, NOS2
21adenylate469.2NOS2, MMP9
22cycloheximide469.2NOS2, MMP9
23dexamethasone46 52 30 1212.1MMP9, NOS2
24estrogen469.1NOS2, MMP9
25vegf469.0NOS2, MMP9
26glutamate468.8NOS2, MMP9

GO Terms for genes affiliated with Internal Hemorrhoid

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Products for genes affiliated with Internal Hemorrhoid

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Internal Hemorrhoid

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet