MCID: INT059
MIFTS: 29

Internal Hemorrhoid malady

Cardiovascular diseases category
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Summaries for Internal Hemorrhoid

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MalaCards based summary: Internal Hemorrhoid, also known as internal hemorrhoids, is related to hypertension and hemorrhoid. An important gene associated with Internal Hemorrhoid is MMP9 (matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)), and among its related pathways are Pathways in cancer and Toll-like receptor signaling pathway. The compounds minocycline and ciglitazone have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Internal Hemorrhoid

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Internal Hemorrhoid, Aliases & Descriptions:

Name: Internal Hemorrhoid 8
 
Internal Hemorrhoids 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:9749
ICD9CM27 455.6
SNOMED-CT57 82985000
ICD1025 I84.1, I84.2

Related Diseases for Internal Hemorrhoid

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Diseases in the Hemorrhoid family:

internal hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.6MMP9
2hemorrhoid10.6
3collagenous colitis10.4NOS2
4portal hypertension10.1
5vascular disease10.0NOS2, MMP9
6osteoarthritis10.0MMP9, NOS2
7multiple sclerosis10.0NOS2, MMP9
8astrocytoma10.0MMP9, NOS2
9arthritis10.0MMP9, NOS2
10glioblastoma10.0NOS2, MMP9
11asthma10.0NOS2, MMP9
12atherosclerosis9.9NOS2, MMP9
13breast cancer9.9MMP9, NOS2
14malignant glioma9.9MMP9, NOS2
15rheumatoid arthritis9.9MMP9, NOS2
16adenocarcinoma9.9NOS2, MMP9
17colonic benign neoplasm9.8MMP9, NOS2
18tongue squamous cell carcinoma9.8NOS2, MMP9

Graphical network of diseases related to Internal Hemorrhoid:



Diseases related to internal hemorrhoid

Symptoms for Internal Hemorrhoid

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Drugs & Therapeutics for Internal Hemorrhoid

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Drug clinical trials:

Search ClinicalTrials for Internal Hemorrhoid

Search NIH Clinical Center for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

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Anatomical Context for Internal Hemorrhoid

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MalaCards organs/tissues related to Internal Hemorrhoid:

32
Liver

Animal Models for Internal Hemorrhoid or affiliated genes

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MGI Mouse Phenotypes related to Internal Hemorrhoid:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1NOS2, MMP9
2MP:00020068.8NOS2, MMP9

Publications for Internal Hemorrhoid

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Articles related to Internal Hemorrhoid:

idTitleAuthorsYear
1
Pyogenic liver abscess as a complication of internal hemorrhoid banding. (24480193)
2014
2
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. (23089912)
2012
3
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. (21633644)
2011
4
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. (17665254)
2007
5
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. (17115317)
2006
6
Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. (16149003)
2005
7
Internal hemorrhoid bleeding in patients with portal hypertension. (3498664)
1987
8
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. (18737501)
1918

Variations for Internal Hemorrhoid

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Expression for genes affiliated with Internal Hemorrhoid

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Expression patterns in normal tissues for genes affiliated with Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for genes affiliated with Internal Hemorrhoid

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Pathways related to Internal Hemorrhoid according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1NOS2, MMP9
2
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1NOS2, MMP9
39.1NOS2, MMP9
49.1NOS2, MMP9

Compounds for genes affiliated with Internal Hemorrhoid

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Compounds related to Internal Hemorrhoid according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1minocycline44 1110.5NOS2, MMP9
2ciglitazone44 2810.5NOS2, MMP9
3parthenolide44 210.5NOS2, MMP9
4ns 39844 6110.5MMP9, NOS2
5alpha lipoic acid449.5NOS2, MMP9
6silymarin449.5NOS2, MMP9
7l-nmma449.5MMP9, NOS2
8fluvastatin44 50 28 1112.5NOS2, MMP9
9celecoxib44 61 28 50 24 1114.5NOS2, MMP9
10pdtc449.4NOS2, MMP9
11resveratrol44 61 24 1112.4MMP9, NOS2
12egcg449.4NOS2, MMP9
13herbimycin a44 6110.4NOS2, MMP9
14curcumin449.4MMP9, NOS2
15n acetylcysteine449.4NOS2, MMP9
16sb 20358044 6110.4NOS2, MMP9
17ly294002449.4MMP9, NOS2
18actinomycin d449.3NOS2, MMP9
19genistein44 28 61 2 24 1114.3NOS2, MMP9
20pge2449.3MMP9, NOS2
21adenylate449.2NOS2, MMP9
22cycloheximide449.2NOS2, MMP9
23dexamethasone44 50 28 1112.1MMP9, NOS2
24estrogen449.1NOS2, MMP9
25vegf449.0NOS2, MMP9
26glutamate448.8NOS2, MMP9

GO Terms for genes affiliated with Internal Hemorrhoid

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Products for genes affiliated with Internal Hemorrhoid

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  • Antibodies
  • Proteins
  • Lysates

Sources for Internal Hemorrhoid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet