MCID: INT059
MIFTS: 18

Internal Hemorrhoid malady

Cardiovascular category

Summaries for Internal Hemorrhoid

Sources:
33MalaCards
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MalaCards: Internal Hemorrhoid, also known as internal hemorrhoids, is related to portal hypertension and collagenous colitis. An important gene associated with Internal Hemorrhoid is MMP9 (matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)), and among its related pathways are Pathways in cancer and Toll-like receptor signaling pathway. The compounds minocycline and ciglitazone have been mentioned in the context of this disorder.

Aliases & Classifications for Internal Hemorrhoid

Sources:
8Disease Ontology, 61UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

internal hemorrhoid 8
internal hemorrhoids 61


External Ids:

Disease Ontology8 DOID:9749
ICD9CM27 455.6
SNOMED-CT57 82985000
ICD1025 I84.1, I84.2

Related Diseases for Internal Hemorrhoid

Sources:
17GeneCards, 18GeneDecks
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Diseases in the hemorrhoid family:

internal hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension10.1
2collagenous colitis10.0NOS2
3gastrointestinal system disease10.0NOS2
4myocarditis10.0NOS2
5hypercholesterolemia10.0NOS2
6diabetic retinopathy10.0NOS2
7encephalomyelitis10.0NOS2
8gastritis10.0NOS2
9cholesteatoma10.0MMP9
10glomerulonephritis10.0NOS2
11vascular disease10.0NOS2
12kawasaki disease10.0MMP9
13abdominal aortic aneurysm10.0MMP9
14hyperglycemia10.0NOS2
15fibrosarcoma10.0MMP9
16meningitis10.0MMP9
17pulmonary fibrosis10.0MMP9
18pulmonary disease, chronic obstructive10.0MMP9

Graphical network of diseases related to Internal Hemorrhoid:



Diseases related to internal hemorrhoid

Clinical Features for Internal Hemorrhoid

Drugs & Therapeutics for Internal Hemorrhoid

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Internal Hemorrhoid

Drug clinical trials:

Search ClinicalTrials for Internal Hemorrhoid

Search NIH Clinical Center for Internal Hemorrhoid

Search CenterWatch for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

Anatomical Context for Internal Hemorrhoid

Animal Models for Internal Hemorrhoid or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Internal Hemorrhoid

Sources:
51PubMed
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Articles related to Internal Hemorrhoid:

idTitleAuthorsYear
1
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. (23089912)
2012
2
PPH-01 versus PPH-03 to perform STARR for the treatment of hemorrhoids associated with large internal rectal prolapse: a prospective multicenter randomized trial. (21737467)
2011
3
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. (21633644)
2011
4
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. (17665254)
2007
5
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. (17115317)
2006
6
Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. (16149003)
2005
7
Internal hemorrhoid bleeding in patients with portal hypertension. (3498664)
1987
8
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. (18737501)
1918

Genetic Variations for Internal Hemorrhoid

Expression for genes affiliated with Internal Hemorrhoid

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for genes affiliated with Internal Hemorrhoid

Sources:
30KEGG, 38NCBI BioSystems Database
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Pathways related to Internal Hemorrhoid according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1NOS2, MMP9
2
Hide members
9.1NOS2, MMP9
39.1NOS2, MMP9
49.1NOS2, MMP9

Compounds for genes affiliated with Internal Hemorrhoid

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Internal Hemorrhoid according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1minocycline45 1110.5NOS2, MMP9
2ciglitazone45 2910.5MMP9, NOS2
3parthenolide45 210.5MMP9, NOS2
4ns 39845 6010.4NOS2, MMP9
5silymarin459.4MMP9, NOS2
6alpha lipoic acid459.4MMP9, NOS2
7l-nmma459.4NOS2, MMP9
8fluvastatin45 50 29 1112.4MMP9, NOS2
9celecoxib45 60 29 50 11 2414.4NOS2, MMP9
10pdtc459.4NOS2, MMP9
11resveratrol45 60 11 2412.4MMP9, NOS2
12egcg459.3NOS2, MMP9
13herbimycin a45 6010.3NOS2, MMP9
14curcumin459.3MMP9, NOS2
15n acetylcysteine459.2NOS2, MMP9
16sb 20358045 6010.2MMP9, NOS2
17ly294002459.1NOS2, MMP9
18pge2459.1NOS2, MMP9
19actinomycin d459.0NOS2, MMP9
20genistein45 29 60 2 11 2413.8NOS2, MMP9

GO Terms for genes affiliated with Internal Hemorrhoid

Products for genes affiliated with Internal Hemorrhoid

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Internal Hemorrhoid

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet