MCID: INT059
MIFTS: 39

Internal Hemorrhoid

Categories: Cardiovascular diseases

Aliases & Classifications for Internal Hemorrhoid

MalaCards integrated aliases for Internal Hemorrhoid:

Name: Internal Hemorrhoid 12 14
Internal Hemorrhoids 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9749
ICD9CM 34 455.6
SNOMED-CT 64 82985000
ICD10 32 I84.1 I84.2

Summaries for Internal Hemorrhoid

MalaCards based summary : Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and brain glioblastoma multiforme. An important gene associated with Internal Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Integrin Pathway. The drugs Lidocaine and Prilocaine have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Internal Hemorrhoid

Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 hemorrhoid 32.7 MMP9 NOS2
2 brain glioblastoma multiforme 10.4 MMP7 MMP9
3 chronic actinic dermatitis 10.4 MMP1 MMP9
4 pediatric multiple sclerosis 10.4 MMP7 MMP9
5 squamous cell carcinoma of the hypopharynx 10.4 MMP1 MMP9
6 tendinopathy 10.4 MMP1 NOS2
7 chromoblastomycosis 10.4 MMP1 MMP9
8 extracranial arteriovenous malformation 10.4 MMP2 MMP9
9 lentigo maligna melanoma 10.4 MMP2 MMP9
10 villous adenocarcinoma 10.4 MMP2 MMP9
11 mycetoma 10.3 MMP9 NOS2
12 acute transverse myelitis 10.3 MMP2 MMP9
13 parotitis 10.3 MMP2 MMP9
14 conjunctival nevus 10.3 MMP2 MMP9
15 middle ear squamous cell carcinoma 10.3 CD34 MMP9
16 microcystic meningioma 10.3 MMP2 MMP9
17 klatskin's tumor 10.3 MMP2 MMP9
18 cholesteatoma of middle ear 10.3 MMP1 MMP9
19 hypercementosis 10.3 MMP2 MMP9
20 corneal ulcer 10.3 MMP2 MMP9
21 sorsby fundus dystrophy 10.3 MMP2 MMP9
22 nasal cavity squamous cell carcinoma 10.3 MMP2 MMP9
23 transverse myelitis 10.3 MMP2 MMP9
24 collagenous colitis 10.3 MMP1 NOS2
25 lung giant cell carcinoma 10.3 MMP2 MMP9
26 fibromatosis, gingival, 1 10.3 MMP1 MMP2
27 conjunctivochalasis 10.2 MMP1 MMP2
28 septic arthritis 10.2 MMP2 MMP7
29 coronary artery aneurysm 10.2 MMP1 MMP7
30 nodular malignant melanoma 10.2 MMP1 MMP2
31 pulmonary emphysema 10.2 MMP1 MMP9
32 pneumothorax 10.1 MMP2 MMP9
33 adult astrocytic tumour 10.1 MMP1 MMP7 MMP9
34 focal myositis 10.1 MMP2 MMP7 MMP9
35 senile ectropion 10.1 MMP2 MMP7 MMP9
36 tongue cancer 10.1 MMP2 MMP9
37 krabbe disease 10.1 CASP3 NOS2
38 adenomyosis 10.1 MMP1 MMP2 MMP9
39 odontogenic myxoma 10.1 MMP1 MMP2 MMP9
40 pelvic organ prolapse 10.1 MMP1 MMP2 MMP9
41 hypertensive heart disease 10.1 MMP1 MMP2 MMP9
42 aortic aneurysm, familial thoracic 1 10.1 MMP1 MMP2 MMP9
43 inguinal hernia 10.1 MMP1 MMP2 MMP9
44 aortic aneurysm, familial abdominal, 1 10.1 MMP1 MMP2 MMP9
45 pulmonary fibrosis, idiopathic 10.1 MMP1 MMP7 MMP9
46 periodontitis 10.1 MMP1 MMP2 MMP9
47 periodontal disease 10.0 MMP1 MMP2 MMP9
48 pharynx cancer 10.0 CASP3 MMP9
49 carotid artery disease 10.0 MMP1 MMP9
50 fibrosarcoma 10.0 MMP1 MMP2 MMP9

Graphical network of the top 20 diseases related to Internal Hemorrhoid:



Diseases related to Internal Hemorrhoid

Symptoms & Phenotypes for Internal Hemorrhoid

MGI Mouse Phenotypes related to Internal Hemorrhoid:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.98 ACE2 CASP3 CD34 HSPA4 MMP7 MMP9
2 homeostasis/metabolism MP:0005376 9.97 ACE2 CASP3 CD34 MMP1 MMP2 MMP7
3 cardiovascular system MP:0005385 9.93 ACE2 CASP3 MMP2 MMP7 MMP9 NOS2
4 immune system MP:0005387 9.92 NOS2 ACE2 CASP3 CD34 MMP1 MMP2
5 digestive/alimentary MP:0005381 9.8 ACE2 CASP3 MMP7 MMP9 NOS2
6 muscle MP:0005369 9.65 MMP2 MMP9 NOS2 ACE2 CASP3
7 neoplasm MP:0002006 9.63 CD34 MMP1 MMP2 MMP7 MMP9 NOS2
8 respiratory system MP:0005388 9.35 ACE2 CASP3 MMP2 MMP9 NOS2
9 vision/eye MP:0005391 9.02 CASP3 MMP2 MMP7 MMP9 NOS2

Drugs & Therapeutics for Internal Hemorrhoid

Drugs for Internal Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
2
Prilocaine Approved Phase 3 721-50-6 4906
3 Central Nervous System Depressants Phase 3
4 Sodium Channel Blockers Phase 3
5 Anesthetics Phase 3
6 Anesthetics, Local Phase 3
7 Diuretics, Potassium Sparing Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Anti-Arrhythmia Agents Phase 3
10
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
11
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
12 Cortisol succinate Phase 2
13 Hydrocortisone 17-butyrate 21-propionate Phase 2
14 Hydrocortisone acetate Phase 2
15 Hydrocortisone-17-butyrate Phase 2
16 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
2 Study About Patient Comfort and Long-term Outcome After Stapled Hemorrhoidopexy Completed NCT01533363 Phase 3
3 Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
4 Safety and Efficacy Study of Anucort HC TM 25mg Rectal Suppositories to Treat Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
5 Study of the Safety and Efficacy of Hydrocortisone Acetate Suppositories, 25 mg in the Treatment of Symptomatic Internal Hemorrhoids Not yet recruiting NCT03335774 Phase 2 Hydrocortisone Acetate Suppository, 25 mg;Placebo (Vehicle) Suppository
6 Comparison Between Single and Triple Rubber Band Ligation for the Treatment of Hemorrhoids Unknown status NCT01383577
7 A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421
8 Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe Completed NCT00630669
9 Safety and Efficacy Study of HET Bipolar System for Treatment of Stage I and Stage II Hemorrhoids Completed NCT01841970
10 Multicenter Prospective Trial on Hemorrhoids Recruiting NCT03245086
11 HET Bipolar System: Validation of Outpatient Hemorrhoid Treatment Active, not recruiting NCT02773420
12 Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD) Terminated NCT01199679

Search NIH Clinical Center for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

Anatomical Context for Internal Hemorrhoid

MalaCards organs/tissues related to Internal Hemorrhoid:

38
Liver

Publications for Internal Hemorrhoid

Articles related to Internal Hemorrhoid:

# Title Authors Year
1
Rectal arterio-venous malformation (AVM) with bleeding of an internal hemorrhoid. ( 26879656 )
2016
2
Pyogenic liver abscess as a complication of internal hemorrhoid banding. ( 24480193 )
2014
3
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. ( 23089912 )
2012
4
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. ( 21633644 )
2011
5
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. ( 17665254 )
2007
6
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. ( 17115317 )
2006
7
[Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. ( 16149003 )
2005
8
Internal hemorrhoid bleeding in patients with portal hypertension. ( 3498664 )
1987
9
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. ( 18737501 )
1918

Variations for Internal Hemorrhoid

Expression for Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for Internal Hemorrhoid

Pathways related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 CASP3 MMP1 MMP2 MMP9 NOS2
2
Show member pathways
13.12 CASP3 MMP1 MMP2 MMP7 MMP9
3 12.63 CASP3 MMP1 MMP2 MMP9 NOS2
4
Show member pathways
12.55 CASP3 MMP1 MMP2 MMP7 MMP9
5
Show member pathways
12.39 MMP1 MMP2 MMP9 NOS2
6
Show member pathways
12.13 CASP3 MMP1 MMP9
7 12.1 CASP3 MMP2 MMP9
8
Show member pathways
12 MMP1 MMP2 MMP7 MMP9
9 11.83 CASP3 MMP9 NOS2
10 11.76 MMP1 MMP2 MMP9 NOS2
11 11.68 MMP2 MMP7 MMP9
12
Show member pathways
11.66 MMP1 MMP2 MMP7 MMP9
13 11.59 MMP1 MMP2 MMP9
14 11.53 CASP3 MMP2 MMP9
15 11.41 CASP3 MMP1 NOS2
16
Show member pathways
11.36 MMP1 MMP2 MMP9 NOS2
17 11.33 MMP2 MMP9
18 11.32 CASP3 MMP1 MMP2 MMP7 MMP9 NOS2
19 11.3 CASP3 MMP1
20
Show member pathways
11.29 MMP2 MMP9
21 11.24 MMP1 MMP2 MMP7 MMP9
22 11.22 MMP1 MMP9
23 11.18 MMP1 MMP2 MMP9
24 11.17 CASP3 MMP2 MMP7 MMP9 NOS2
25 11.15 CASP3 MMP2
26 11.14 ACE2 MMP2 MMP9
27 11.02 MMP2 MMP9
28 10.97 ACE2 MMP2 MMP9
29 10.92 MMP1 MMP2
30 10.73 MMP1 MMP7 MMP9

GO Terms for Internal Hemorrhoid

Cellular components related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ACE2 CD34 MMP1 MMP2 MMP7 MMP9
2 extracellular matrix GO:0031012 9.26 MMP1 MMP2 MMP7 MMP9
3 proteinaceous extracellular matrix GO:0005578 8.92 MMP1 MMP2 MMP7 MMP9

Biological processes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.63 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 leukocyte migration GO:0050900 9.58 CD34 MMP1 MMP9
3 embryo implantation GO:0007566 9.43 MMP2 MMP9
4 response to hypoxia GO:0001666 9.43 CASP3 MMP2 NOS2
5 endodermal cell differentiation GO:0035987 9.37 MMP2 MMP9
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.32 MMP2 MMP9
7 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP2 MMP7 MMP9
8 collagen catabolic process GO:0030574 8.92 MMP1 MMP2 MMP7 MMP9

Molecular functions related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.88 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 zinc ion binding GO:0008270 9.77 ACE2 MMP1 MMP2 MMP7 MMP9
3 serine-type endopeptidase activity GO:0004252 9.56 MMP1 MMP2 MMP7 MMP9
4 endopeptidase activity GO:0004175 9.5 ACE2 MMP1 MMP9
5 metalloendopeptidase activity GO:0004222 9.46 MMP1 MMP2 MMP7 MMP9
6 peptidase activity GO:0008233 9.43 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
7 metallopeptidase activity GO:0008237 9.02 ACE2 MMP1 MMP2 MMP7 MMP9

Sources for Internal Hemorrhoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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