MCID: INT059
MIFTS: 38

Internal Hemorrhoid malady

Categories: Cardiovascular diseases

Aliases & Classifications for Internal Hemorrhoid

Aliases & Descriptions for Internal Hemorrhoid:

Name: Internal Hemorrhoid 12 14
Internal Hemorrhoids 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9749
ICD9CM 35 455.6
SNOMED-CT 64 82985000
ICD10 33 I84.1 I84.2
UMLS 69 C0041844

Summaries for Internal Hemorrhoid

MalaCards based summary : Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and mycobacterium xenopi. An important gene associated with Internal Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Nitrendipine and Captopril have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Internal Hemorrhoid

Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 hemorrhoid 11.3
2 mycobacterium xenopi 10.3 MMP9 NOS2
3 diastolic heart failure 10.3 MMP9 NOS2
4 facio skeletal genital syndrome rippberger type 10.3 MMP2 MMP9
5 adult-onset distal myopathy due to vcp mutation 10.3 MMP1 MMP9
6 diffuse large b-cell lymphoma 10.3 MMP1 MMP9
7 leukoencephalopathy palmoplantar keratoderma 10.3 MMP2 MMP9
8 brain meningioma 10.3 MMP7 MMP9
9 thymus adenocarcinoma 10.3 MMP2 MMP9
10 chronic diarrhea due to guanylate cyclase 2c overactivity 10.3 MMP1 NOS2
11 neonatal hypoxic and ischemic brain injury 10.2 MMP2 MMP9
12 penis agenesis 10.2 MMP7 MMP9
13 chondrodysplasia punctata, rhizomelic, type 1 10.2 MMP7 MMP9
14 ectropion 10.2 MMP1 MMP9
15 kidney osteogenic sarcoma 10.2 MMP9 VEGFA
16 viral meningitis 10.2 MMP2 MMP9
17 lymphocytic colitis 10.2 MMP2 MMP9
18 renal pelvis squamous cell carcinoma 10.2 CD34 MMP9
19 noonan syndrome 4 10.2 MMP1 MMP2
20 hepatic vascular disease 10.2 MMP9 VEGFA
21 adenocarcinoma in situ 10.2 MMP2 MMP9
22 large cell medulloblastoma 10.2 MMP9 VEGFA
23 appendix carcinoid tumor 10.2 MMP2 MMP9
24 polyp of corpus uteri 10.2 MMP1 MMP2
25 corneal staphyloma 10.2 MMP2 MMP9
26 schwannomatosis 10.2 MMP2 MMP9
27 angiomyoma 10.2 MMP1 MMP2
28 striated muscle rhabdoid tumor 10.2 MMP2 MMP9
29 retinal artery occlusion 10.2 MMP2 MMP9
30 bulbomembranous urethral cancer 10.2 MMP2 MMP9
31 thyroid angiosarcoma 10.2 CD34 VEGFA
32 cystic lymphangioma 10.2 MMP1 MMP7 MMP9
33 acute tricyclic antidepressant poisoning 10.1 MMP2 MMP7 MMP9
34 tinea profunda 10.1 MMP2 MMP7 MMP9
35 breast papillary carcinoma 10.1 MMP2 MMP9
36 retinal drusen 10.1 MMP2 MMP7 MMP9
37 laryngeal adenoid cystic carcinoma 10.1 CD34 VEGFA
38 laryngostenosis 10.1 MMP1 MMP2 MMP9
39 nodular cutaneous amyloidosis 10.1 MMP1 MMP2 MMP9
40 breast abscess 10.1 MMP1 MMP2 MMP9
41 central nervous system teratoma 10.1 MMP1 MMP2 MMP9
42 mixed ductal-endocrine carcinoma 10.1 MMP1 MMP2 MMP9
43 histiocytosis 10.1 MMP1 MMP2 MMP9
44 localized junctional epidermolysis bullosa, non-herlitz type 10.1 MMP1 VEGFA
45 pediatric osteosarcoma 10.1 MMP1 MMP2 MMP9
46 polyneuropathy in collagen vascular disease 10.1 HSPA4 MMP9
47 spastic hemiplegia 10.1 MMP1 MMP9
48 maxillary neoplasm 10.1 MMP2 MMP9 VEGFA
49 marginal zone b-cell lymphoma 10.1 MMP2 MMP9 VEGFA
50 spinal meninges cancer 10.1 CD34 MMP2 MMP9

Graphical network of the top 20 diseases related to Internal Hemorrhoid:



Diseases related to Internal Hemorrhoid

Symptoms & Phenotypes for Internal Hemorrhoid

MGI Mouse Phenotypes related to Internal Hemorrhoid:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 ACE2 CASP3 CD34 MMP1 MMP2 MMP7
2 immune system MP:0005387 10.09 ACE2 CASP3 CD34 MMP1 MMP2 MMP7
3 cardiovascular system MP:0005385 10.07 ACE2 CASP3 MMP2 MMP7 MMP9 NOS2
4 cellular MP:0005384 10.05 HSPA4 MMP7 MMP9 NOS2 VEGFA CASP3
5 hematopoietic system MP:0005397 10.02 CASP3 CD34 MMP2 MMP7 MMP9 NOS2
6 digestive/alimentary MP:0005381 9.97 ACE2 CASP3 MMP7 MMP9 NOS2 VEGFA
7 mortality/aging MP:0010768 9.97 ACE2 CASP3 HSPA4 MMP2 MMP7 MMP9
8 integument MP:0010771 9.88 ACE2 CASP3 CD34 MMP9 NOS2 VEGFA
9 muscle MP:0005369 9.8 ACE2 CASP3 MMP2 MMP9 NOS2 VEGFA
10 neoplasm MP:0002006 9.8 CD34 MMP1 MMP2 MMP7 MMP9 NOS2
11 renal/urinary system MP:0005367 9.55 ACE2 CASP3 MMP9 NOS2 VEGFA
12 respiratory system MP:0005388 9.43 MMP9 NOS2 VEGFA ACE2 CASP3 MMP2
13 vision/eye MP:0005391 9.1 CASP3 MMP2 MMP7 MMP9 NOS2 VEGFA

Drugs & Therapeutics for Internal Hemorrhoid

Drugs for Internal Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitrendipine Approved Phase 4 39562-70-4 4507
2
Captopril Approved Phase 4 62571-86-2 44093
3
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
4
Acetylcholine Approved Phase 4 51-84-3 187
5 calcium channel blockers Phase 4
6 diuretics Phase 4
7
protease inhibitors Phase 4
8 Natriuretic Agents Phase 4
9 Sodium Chloride Symporter Inhibitors Phase 4
10 HIV Protease Inhibitors Phase 4
11 Vasodilator Agents Phase 4
12 Angiotensin-Converting Enzyme Inhibitors Phase 4
13 Antihypertensive Agents Phase 4
14 Calcium, Dietary Phase 4
15 Cholinergic Agents Phase 4
16 Neurotransmitter Agents Phase 4
17 Pharmaceutical Solutions Phase 4
18 abobotulinumtoxinA Phase 4
19 incobotulinumtoxinA Phase 4
20 onabotulinumtoxinA Phase 4
21 Botulinum Toxins Phase 4
22 Botulinum Toxins, Type A Phase 4
23
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
24
Prilocaine Approved Phase 3 721-50-6 4906
25 Sodium Channel Blockers Phase 3
26 Anesthetics Phase 3
27 Diuretics, Potassium Sparing Phase 3
28 Peripheral Nervous System Agents Phase 3
29 Anesthetics, Local Phase 3
30 Anti-Arrhythmia Agents Phase 3
31 Central Nervous System Depressants Phase 3
32
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
33
Butyric Acid Experimental Phase 2 107-92-6 264
34 Cortisol succinate Phase 2
35 Hydrocortisone 17-butyrate 21-propionate Phase 2
36 Hydrocortisone acetate Phase 2
37 Hydrocortisone-17-butyrate Phase 2
38 Anti-Inflammatory Agents Phase 2
39 Trimebutine Approved 39133-31-8
40 Chelating Agents
41 Gastrointestinal Agents
42 Parasympatholytics
43 Autonomic Agents

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Treatment of Hypertension in Tibetan Adult Population Unknown status NCT02217852 Phase 4
2 Pain Relief for Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
3 Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids Completed NCT02130830 Phase 3
4 Study About Patient Comfort and Long-term Outcome After Stapled Hemorrhoidopexy Completed NCT01533363 Phase 3
5 Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3
6 Safety and Efficacy Study of Anucort HC TM 25mg Rectal Suppositories to Treat Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2
7 Comparison Between Single and Triple Rubber Band Ligation for the Treatment of Hemorrhoids Unknown status NCT01383577
8 A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421
9 The Relationship Between Haemorrhoids and Pelvic Vein Reflux Unknown status NCT02039570
10 Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe Completed NCT00630669
11 Safety and Efficacy Study of HET Bipolar System for Treatment of Stage I and Stage II Hemorrhoids Completed NCT01841970
12 The Feasibility of Self or Partner-assisted Digital Anal Exam Screening Completed NCT02384005
13 Feasibility of Superior Rectal Artery Embolization for the Treatment of Hemorrhoidal Disease Recruiting NCT02303925
14 HET Bipolar System: Validation of Outpatient Hemorrhoid Treatment Active, not recruiting NCT02773420
15 Effect of Topical Trimebutine on Pain After Hemorrhoidectomy Not yet recruiting NCT03036111
16 Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD) Terminated NCT01199679

Search NIH Clinical Center for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

Anatomical Context for Internal Hemorrhoid

MalaCards organs/tissues related to Internal Hemorrhoid:

39
Liver

Publications for Internal Hemorrhoid

Articles related to Internal Hemorrhoid:

id Title Authors Year
1
Rectal arterio-venous malformation (AVM) with bleeding of an internal hemorrhoid. ( 26879656 )
2016
2
Pyogenic liver abscess as a complication of internal hemorrhoid banding. ( 24480193 )
2014
3
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. ( 23089912 )
2012
4
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. ( 21633644 )
2011
5
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. ( 17665254 )
2007
6
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. ( 17115317 )
2006
7
[Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. ( 16149003 )
2005
8
Internal hemorrhoid bleeding in patients with portal hypertension. ( 3498664 )
1987
9
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. ( 18737501 )
1918

Variations for Internal Hemorrhoid

Expression for Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for Internal Hemorrhoid

Pathways related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 CASP3 MMP1 MMP2 MMP7 MMP9 VEGFA
2
Show member pathways
13.16 CASP3 MMP1 MMP2 MMP9 NOS2 VEGFA
3
Show member pathways
12.62 CASP3 MMP2 MMP9 VEGFA
4
Show member pathways
12.59 CASP3 MMP1 MMP2 MMP7 MMP9
5 12.4 CASP3 MMP1 MMP2 MMP9 NOS2 VEGFA
6
Show member pathways
12.16 CASP3 MMP1 MMP9
7 12.16 CASP3 MMP2 MMP9 VEGFA
8
Show member pathways
12.09 CASP3 MMP1 VEGFA
9 11.99 CASP3 MMP1 VEGFA
10 11.94 MMP2 MMP9 VEGFA
11 11.86 CASP3 MMP9 NOS2
12
Show member pathways
11.77 MMP1 MMP2 MMP7 MMP9
13 11.76 CASP3 MMP2 VEGFA
14 11.71 MMP1 MMP2 MMP9 NOS2 VEGFA
15 11.7 MMP2 MMP7 MMP9
16 11.6 MMP1 MMP2 MMP9 VEGFA
17 11.56 CASP3 MMP2 MMP9
18 11.5 CASP3 MMP9 VEGFA
19 11.49 MMP1 MMP2 MMP7 MMP9
20 11.38 CASP3 MMP1 NOS2 VEGFA
21 11.38 CASP3 MMP1 MMP2 MMP7 MMP9 NOS2
22 11.37 CASP3 MMP2 MMP7 MMP9 NOS2
23 11.26 MMP1 MMP9
24 11.24 ACE2 MMP2 MMP9
25 11.23 NOS2 VEGFA
26 11.22 MMP1 MMP2 MMP9
27 11.17 CASP3 MMP2
28
Show member pathways
11.15 MMP1 MMP2 MMP9 NOS2 VEGFA
29 11.09 ACE2 MMP2 MMP9
30 11.06 MMP2 MMP9
31 11.02 MMP9 VEGFA
32 10.96 MMP1 MMP2
33 10.9 MMP1 VEGFA
34 10.86 MMP1 MMP7 MMP9
35 10.82 MMP1 VEGFA

GO Terms for Internal Hemorrhoid

Cellular components related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ACE2 CD34 MMP1 MMP2 MMP7 MMP9
2 cell surface GO:0009986 9.56 ACE2 CD34 MMP7 VEGFA
3 extracellular matrix GO:0031012 9.26 MMP1 MMP2 MMP7 MMP9
4 proteinaceous extracellular matrix GO:0005578 9.02 MMP1 MMP2 MMP7 MMP9 VEGFA

Biological processes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.63 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 leukocyte migration GO:0050900 9.61 CD34 MMP1 MMP9
3 response to hypoxia GO:0001666 9.56 CASP3 MMP2 NOS2 VEGFA
4 endodermal cell differentiation GO:0035987 9.4 MMP2 MMP9
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.37 MMP2 MMP9
6 macrophage differentiation GO:0030225 9.32 MMP9 VEGFA
7 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP2 MMP7 MMP9
8 collagen catabolic process GO:0030574 8.92 MMP1 MMP2 MMP7 MMP9

Molecular functions related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.85 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 zinc ion binding GO:0008270 9.8 ACE2 MMP1 MMP2 MMP7 MMP9
3 serine-type endopeptidase activity GO:0004252 9.56 MMP1 MMP2 MMP7 MMP9
4 endopeptidase activity GO:0004175 9.5 ACE2 MMP1 MMP9
5 metalloendopeptidase activity GO:0004222 9.46 MMP1 MMP2 MMP7 MMP9
6 peptidase activity GO:0008233 9.43 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
7 metallopeptidase activity GO:0008237 9.02 ACE2 MMP1 MMP2 MMP7 MMP9

Sources for Internal Hemorrhoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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