MCID: INT042
MIFTS: 37

Internuclear Ophthalmoplegia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

MalaCards integrated aliases for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:538
ICD10 33 H51.2
ICD9CM 35 378.86
MeSH 42 D015835
SNOMED-CT 64 49823009
UMLS 69 C0152134

Summaries for Internuclear Ophthalmoplegia

MalaCards based summary : Internuclear Ophthalmoplegia is related to temporal arteritis and hypersplenism, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs 4-Aminopyridine and Potassium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and pons, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 72 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

Related Diseases for Internuclear Ophthalmoplegia

Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
id Related Disease Score Top Affiliating Genes
1 temporal arteritis 30.4 MBP MOG
2 hypersplenism 10.7 AQP4 MBP
3 lens disease 10.6 AQP4 MBP
4 tricho onychic dysplasia 10.6 AQP4 MBP
5 alopecia intellectual disability syndrome 2 10.5 MBP MOG
6 ulcerative colitis 10.5 AQP4 MBP
7 3-hydroxyacyl-coa dehydrogenase deficiency 10.5 HEXA MBP
8 central neurocytoma 10.5 AQP4 NF1
9 active cochlear meniere's disease 10.5 HEXA LGI1 MBP
10 cogan-reese syndrome 10.5 AQP4 IFNB1 MBP
11 tracheal stenosis 10.3 AQP4 MBP MOG
12 cellular schwannoma 10.3 AQP4 MBP MOG
13 pulmonary hemosiderosis 10.3 AQP4 MBP MOG
14 status epilepticus 10.3 AQP4 MBP MOG
15 diabetic peripheral angiopathy 10.3 AQP4 IFNB1 MOG
16 fuchs' endothelial dystrophy 10.3 KANTR MBP
17 adenosquamous bile duct carcinoma 10.3 KANTR MBP
18 littre gland carcinoma 10.3 KANTR MBP
19 cerebral arteritis 10.2 NF1 PSEN1
20 interstitial emphysema 10.2 KANTR MBP
21 ovarian surface papilloma 10.2 HCRT MBP MOG
22 head injury 10.2
23 exotropia 10.2
24 lupus erythematosus 10.2
25 systemic lupus erythematosus 10.2
26 ataxia 10.2
27 autoimmune-related retinopathy and optic neuropathy 10.1 MBP NF1 OMG
28 fungal meningitis 10.1 KANTR NF1
29 hepatopulmonary syndrome 10.1 AQP4 HCRT MOG
30 myasthenia gravis 10.1
31 pancreatoblastoma 10.1 MBP NF1
32 cervicitis 10.1
33 meningitis 10.1
34 submandibular adenitis 10.1 MBP PSEN1
35 neonatal jaundice 10.0 AQP4 IFNB1 MBP MOG
36 proximal symphalangism 10.0 IFNB1 MBP MOG OMG
37 causalgia 10.0 AQP4 IFNB1 MBP MOG
38 hypolipoproteinemia 10.0 IFNB1 KANTR MBP
39 newborn respiratory distress syndrome 10.0 AQP4 HCRT MBP MOG
40 diffuse alopecia areata 10.0 KANTR PSEN1
41 neuromyelitis optica 10.0
42 aneurysm 10.0
43 advanced sleep phase syndrome, familial, 1 10.0 AQP4 IFNB1 MBP MOG
44 peripheral vertigo 10.0 KANTR NF1
45 pleomorphic carcinoma 10.0 AQP4 KANTR MOG
46 cerebellar ataxia 9.9
47 ptosis 9.9
48 strabismus 9.9
49 neuronitis 9.9
50 vasculitis 9.9

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to Internuclear Ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 NF1 PSEN1 AQP4 CD55 GBA HCRT
2 growth/size/body region MP:0005378 10.06 AQP4 GBA HCRT HEXA LGI1 MBP
3 hematopoietic system MP:0005397 10.02 AQP4 CD55 CXCR5 GBA IFNB1 MBP
4 homeostasis/metabolism MP:0005376 9.97 HCRT HEXA IFNB1 MBP NF1 OMG
5 immune system MP:0005387 9.86 AQP4 CXCR5 GBA IFNB1 MBP MOG
6 nervous system MP:0003631 9.85 AQP4 GBA HCRT HEXA IFNB1 LGI1
7 normal MP:0002873 9.43 GBA IFNB1 MBP NF1 OMG PSEN1
8 vision/eye MP:0005391 9.17 AQP4 HEXA LGI1 MBP MOG NF1

Drugs & Therapeutics for Internuclear Ophthalmoplegia

Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 2 504-24-5 1727
2 Potassium Channel Blockers Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis Recruiting NCT02391961 Phase 2 Dalfampridine;Placebo

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

Anatomical Context for Internuclear Ophthalmoplegia

MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

39
Eye, Brain, Pons, Testes

Publications for Internuclear Ophthalmoplegia

Articles related to Internuclear Ophthalmoplegia:

(show top 50) (show all 269)
id Title Authors Year
1
Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review. ( 28774543 )
2017
2
Internuclear Ophthalmoplegia Secondary to Cocaine Abuse. ( 28265477 )
2017
3
Post-operative unilateral internuclear ophthalmoplegia following basilar pneumocephalus after resection of C1 intradural extramedullary tumor. ( 28558345 )
2017
4
Isolated Internuclear Ophthalmoplegia After Massive Supratentorial Epidural Hematoma: A Case Report and Review of the Literature. ( 28143728 )
2017
5
Internuclear Ophthalmoplegia ( 28722999 )
2017
6
Bilateral internuclear ophthalmoplegia following head trauma. ( 28440256 )
2017
7
A rare cause for visual symptoms in multiple sclerosis: posterior internuclear ophthalmoplegia of Lutz, a historical misnomer. ( 28194531 )
2017
8
Can Wernekink commissure syndrome and wall-eyed bilateral internuclear ophthalmoplegia be ascribed to neuromyelitis optica spectrum disorder? ( 28681309 )
2017
9
Saccadic hypermetria on abduction of the ipsilesional eye in internuclear ophthalmoplegia. ( 28431591 )
2017
10
Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction. ( 26995360 )
2016
11
Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction. ( 27567293 )
2016
12
Internuclear ophthalmoplegia. ( 27927777 )
2016
13
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. ( 26944331 )
2016
14
Unilateral internuclear ophthalmoplegia, strabismus and transient torsional nystagmus in focal pontine infarction. ( 27448548 )
2016
15
Visualisation of the medial longitudinal fasciculus using fibre tractography in multiple sclerosis patients with internuclear ophthalmoplegia. ( 26787313 )
2016
16
A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging. ( 27857923 )
2016
17
Bilateral Internuclear Ophthalmoplegia as a Presenting Manifestation of Primary SjAPgren's Syndrome. ( 27928415 )
2016
18
Gaze palsy and exotropia in internuclear ophthalmoplegia. ( 25911021 )
2015
19
Wall-eyed bilateral internuclear ophthalmoplegia. ( 26053827 )
2015
20
Unilateral internuclear ophthalmoplegia with upbeat nystagmus from ischemic origin: evidence for the paramedian tract neurons as a vertical neural integrator? ( 26550407 )
2015
21
Internuclear Ophthalmoplegia Associated with Anti-TNFI+ Medication. ( 25790247 )
2015
22
Large basilar tip aneurysm causing anterior internuclear ophthalmoplegia. ( 25670869 )
2015
23
Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients. ( 24599322 )
2014
24
Wall-eyed bilateral internuclear ophthalmoplegia: review of pathogenesis, diagnosis, prognosis and management. ( 25308307 )
2014
25
Periprocedural stroke presenting as isolated unilateral internuclear ophthalmoplegia. ( 25114281 )
2014
26
Jerky seesaw nystagmus with internuclear ophthalmoplegia as the presenting finding in systemic lupus erythematosus. ( 25455550 )
2014
27
Unilateral Internuclear Ophthalmoplegia as an Isolated Presentation of Metastatic Melanoma. ( 25232840 )
2014
28
Brainstem Infarction with Wall-eyed Bilateral Internuclear Ophthalmoplegia Syndrome and Vertical One-and-a-Half Syndrome. ( 24424330 )
2014
29
Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. ( 24770935 )
2014
30
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. ( 24870222 )
2014
31
Ocular vestibular evoked myogenic potentials to head tap and cervical vestibular evoked myogenic potentials to air-conducted sounds in isolated internuclear ophthalmoplegia. ( 24238926 )
2013
32
Bilateral internuclear ophthalmoplegia associated with pediatric brain tumor progression: a case series and review of the literature. ( 24048548 )
2013
33
Reversible cortical blindness and internuclear ophthalmoplegia after neurosurgical operation: case report and review of the literature. ( 23042139 )
2013
34
Pediatric internuclear ophthalmoplegia. ( 23470988 )
2013
35
Images in clinical medicine. Bilateral internuclear ophthalmoplegia in multiple sclerosis. ( 23323922 )
2013
36
Evolution of symmetric upbeat into dissociated torsional-upbeat nystagmus in internuclear ophthalmoplegia. ( 23664561 )
2013
37
Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct. ( 23830476 )
2013
38
An unusual aetiology for internuclear ophthalmoplegia. ( 23737577 )
2013
39
Motion diplopia in an isolated unilateral internuclear ophthalmoplegia: a new neurological symptom? ( 22790327 )
2013
40
Rapid reversal of wall-eyed bilateral internuclear ophthalmoplegia. ( 22410451 )
2012
41
Neurocysticercosis presenting as isolated wall-eyed monocular internuclear ophthalmoplegia with contraversive ocular tilt reaction. ( 22346205 )
2012
42
Unilateral internuclear ophthalmoplegia after minor head injury. ( 22461944 )
2012
43
Teaching NeuroImages: Duret hemorrhage due to bilateral subdural hematomas causing internuclear ophthalmoplegia. ( 22987747 )
2012
44
Jerky see-saw nystagmus in internuclear ophthalmoplegia from a lower pontine lesion. ( 23166883 )
2012
45
A small pontine infarct on DWI as a lesion responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome. ( 21655962 )
2012
46
Transposition surgery for internuclear ophthalmoplegia. ( 22881482 )
2012
47
Pure upbeat nystagmus in association with bilateral internuclear ophthalmoplegia. ( 22445483 )
2012
48
Complete bilateral horizontal internuclear ophthalmoplegia as a sign of multiple sclerosis relapse. ( 23040719 )
2012
49
Ocular tilt reaction, internuclear ophthalmoplegia, and torsional nystagmus following mitral commissurotomy. ( 23084391 )
2012
50
Bilateral internuclear ophthalmoplegia with unilateral horizontal gaze paresis. ( 22728510 )
2012

Variations for Internuclear Ophthalmoplegia

Expression for Internuclear Ophthalmoplegia

Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for Internuclear Ophthalmoplegia

Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.43 HCRT MBP NF1 PSEN1
2 11.21 AQP4 MBP OMG
3 10.41 GBA HEXA

GO Terms for Internuclear Ophthalmoplegia

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 T cell activation involved in immune response GO:0002286 9.16 IFNB1 PSEN1
2 negative regulation of axonogenesis GO:0050771 8.96 OMG PSEN1
3 skin morphogenesis GO:0043589 8.62 GBA PSEN1

Sources for Internuclear Ophthalmoplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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