MCID: INT042
MIFTS: 37

Internuclear Ophthalmoplegia malady

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

Aliases & Descriptions for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:538
ICD10 33 H51.2
ICD9CM 35 378.86
MeSH 42 D015835
SNOMED-CT 64 49823009
UMLS 69 C0152134

Summaries for Internuclear Ophthalmoplegia

MalaCards based summary : Internuclear Ophthalmoplegia is related to head injury and childhood brainstem astrocytoma, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs 4-Aminopyridine and Potassium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and pons, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 71 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

Related Diseases for Internuclear Ophthalmoplegia

Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 head injury 10.2
2 childhood brainstem astrocytoma 10.2 AQP4 MBP
3 exotropia 10.2
4 lupus erythematosus 10.2
5 active cochlear meniere's disease 10.2 HEXA LGI1 MBP
6 crest syndrome 10.2 AQP4 IFNB1 MBP
7 alopecia-intellectual disability syndrome 10.2 MBP MOG
8 systemic lupus erythematosus 10.2
9 ataxia 10.2
10 myasthenia gravis 10.1
11 schwannoma of twelfth cranial nerve 10.1 AQP4 MBP MOG
12 pulmonary hemosiderosis 10.1 AQP4 MBP MOG
13 endobronchial lipoma 10.1 AQP4 IFNB1 MOG
14 status epilepticus 10.1 AQP4 MBP MOG
15 central neurocytoma 10.1 AQP4 NF1
16 lipomatosis, multiple symmetric 10.1 MBP MOG
17 cervical adenoid basal carcinoma 10.1 HCRT MBP MOG
18 cervicitis 10.1
19 meningitis 10.1
20 cerebral arteritis 10.1 NF1 PSEN1
21 acute serous otitis media 10.1 KANTR MBP
22 ampulla of vater adenosquamous carcinoma 10.0 KANTR MBP
23 persistent mullerian duct syndrome 10.0 IFNB1 MBP MOG OMG
24 neonatal jaundice 10.0 AQP4 IFNB1 MBP MOG
25 niemann-pick disease 10.0 AQP4 HCRT MBP MOG
26 aneurysm 10.0
27 fungal meningitis 10.0 KANTR NF1
28 complex regional pain syndrome 10.0 AQP4 IFNB1 MBP MOG
29 advanced sleep phase syndrome, familial, 1 10.0 AQP4 IFNB1 MBP MOG
30 urethritis 9.9 KANTR MBP PSEN1
31 acrofrontofacionasal dysostosis 9.9 KANTR MBP PSEN1
32 cerebellar ataxia 9.9
33 neuromyelitis optica 9.9
34 ptosis 9.9
35 strabismus 9.9
36 neuronitis 9.9
37 vasculitis 9.9
38 glioma 9.9
39 tuberculous meningitis 9.9
40 angina pectoris 9.9 KANTR LGI1 PSEN1
41 nerve fibre bundle defect 9.9 AQP4 KANTR MBP MOG
42 schwannoma of jugular foramen 9.9 KANTR MBP
43 acquired metabolic disease 9.9 KANTR PSEN1
44 chiari malformation type ii 9.8
45 temporal arteritis 9.8
46 chronic inflammatory demyelinating polyneuropathy 9.8
47 hydrocephalus 9.8
48 african tick-bite fever 9.8
49 myelomeningocele 9.8
50 thrombosis 9.8

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to Internuclear Ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 AQP4 CD55 GBA HCRT HEXA LGI1
2 growth/size/body region MP:0005378 9.91 AQP4 GBA HCRT HEXA LGI1 MBP
3 hematopoietic system MP:0005397 9.81 CD55 CXCR5 GBA IFNB1 MBP MOG
4 nervous system MP:0003631 9.65 AQP4 GBA HCRT HEXA IFNB1 LGI1
5 vision/eye MP:0005391 9.17 AQP4 HEXA LGI1 MBP MOG NF1

Drugs & Therapeutics for Internuclear Ophthalmoplegia

Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 2 504-24-5 1727
2 Potassium Channel Blockers Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis Recruiting NCT02391961 Phase 2

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

Anatomical Context for Internuclear Ophthalmoplegia

MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

39
Eye, Brain, Pons, Testes

Publications for Internuclear Ophthalmoplegia

Articles related to Internuclear Ophthalmoplegia:

(show top 50) (show all 260)
id Title Authors Year
1
Bilateral Internuclear Ophthalmoplegia as a Presenting Manifestation of Primary SjAPgren's Syndrome. ( 27928415 )
2016
2
Visualisation of the medial longitudinal fasciculus using fibre tractography in multiple sclerosis patients with internuclear ophthalmoplegia. ( 26787313 )
2016
3
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. ( 26944331 )
2016
4
Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction. ( 27567293 )
2016
5
A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging. ( 27857923 )
2016
6
Internuclear ophthalmoplegia. ( 27927777 )
2016
7
Unilateral internuclear ophthalmoplegia, strabismus and transient torsional nystagmus in focal pontine infarction. ( 27448548 )
2016
8
Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction. ( 26995360 )
2016
9
Large basilar tip aneurysm causing anterior internuclear ophthalmoplegia. ( 25670869 )
2015
10
Unilateral internuclear ophthalmoplegia with upbeat nystagmus from ischemic origin: evidence for the paramedian tract neurons as a vertical neural integrator? ( 26550407 )
2015
11
Wall-eyed bilateral internuclear ophthalmoplegia. ( 26053827 )
2015
12
Gaze palsy and exotropia in internuclear ophthalmoplegia. ( 25911021 )
2015
13
Internuclear Ophthalmoplegia Associated with Anti-TNFI+ Medication. ( 25790247 )
2015
14
Jerky seesaw nystagmus with internuclear ophthalmoplegia as the presenting finding in systemic lupus erythematosus. ( 25455550 )
2014
15
Brainstem Infarction with Wall-eyed Bilateral Internuclear Ophthalmoplegia Syndrome and Vertical One-and-a-Half Syndrome. ( 24424330 )
2014
16
Wall-eyed bilateral internuclear ophthalmoplegia: review of pathogenesis, diagnosis, prognosis and management. ( 25308307 )
2014
17
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. ( 24870222 )
2014
18
Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients. ( 24599322 )
2014
19
Periprocedural stroke presenting as isolated unilateral internuclear ophthalmoplegia. ( 25114281 )
2014
20
Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. ( 24770935 )
2014
21
Unilateral Internuclear Ophthalmoplegia as an Isolated Presentation of Metastatic Melanoma. ( 25232840 )
2014
22
Pediatric internuclear ophthalmoplegia. ( 23470988 )
2013
23
An unusual aetiology for internuclear ophthalmoplegia. ( 23737577 )
2013
24
Ocular vestibular evoked myogenic potentials to head tap and cervical vestibular evoked myogenic potentials to air-conducted sounds in isolated internuclear ophthalmoplegia. ( 24238926 )
2013
25
Reversible cortical blindness and internuclear ophthalmoplegia after neurosurgical operation: case report and review of the literature. ( 23042139 )
2013
26
Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct. ( 23830476 )
2013
27
Bilateral internuclear ophthalmoplegia associated with pediatric brain tumor progression: a case series and review of the literature. ( 24048548 )
2013
28
Images in clinical medicine. Bilateral internuclear ophthalmoplegia in multiple sclerosis. ( 23323922 )
2013
29
Motion diplopia in an isolated unilateral internuclear ophthalmoplegia: a new neurological symptom? ( 22790327 )
2013
30
Evolution of symmetric upbeat into dissociated torsional-upbeat nystagmus in internuclear ophthalmoplegia. ( 23664561 )
2013
31
Unilateral internuclear ophthalmoplegia after minor head injury. ( 22461944 )
2012
32
A small pontine infarct on DWI as a lesion responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome. ( 21655962 )
2012
33
Ocular tilt reaction, internuclear ophthalmoplegia, and torsional nystagmus following mitral commissurotomy. ( 23084391 )
2012
34
Complete bilateral horizontal internuclear ophthalmoplegia as a sign of multiple sclerosis relapse. ( 23040719 )
2012
35
Bilateral internuclear ophthalmoplegia with unilateral horizontal gaze paresis. ( 22728510 )
2012
36
Jerky see-saw nystagmus in internuclear ophthalmoplegia from a lower pontine lesion. ( 23166883 )
2012
37
Teaching NeuroImages: Duret hemorrhage due to bilateral subdural hematomas causing internuclear ophthalmoplegia. ( 22987747 )
2012
38
Neurocysticercosis presenting as isolated wall-eyed monocular internuclear ophthalmoplegia with contraversive ocular tilt reaction. ( 22346205 )
2012
39
Rapid reversal of wall-eyed bilateral internuclear ophthalmoplegia. ( 22410451 )
2012
40
Transposition surgery for internuclear ophthalmoplegia. ( 22881482 )
2012
41
Pure upbeat nystagmus in association with bilateral internuclear ophthalmoplegia. ( 22445483 )
2012
42
Patterns of dissociate torsional-vertical nystagmus in internuclear ophthalmoplegia. ( 21951004 )
2011
43
Pure isolated internuclear ophthalmoplegia. ( 21841349 )
2011
44
Ocular vestibular evoked myogenic potentials are abnormal in internuclear ophthalmoplegia. ( 21093360 )
2011
45
Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody. ( 21300735 )
2011
46
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. ( 21421770 )
2011
47
"Top of the basilar" occlusion causing bilateral internuclear ophthalmoplegia. ( 21372475 )
2011
48
Bilateral Internuclear Ophthalmoplegia in a Patient with Devic's Neuromyelitis Optica. ( 21113284 )
2010
49
Wall-eyed bilateral internuclear ophthalmoplegia after ruptured aneurysm. ( 20457967 )
2010
50
Ocular tilt reaction and internuclear ophthalmoplegia associated with venous sinus thrombosis: an unusual case. ( 19091852 )
2010

Variations for Internuclear Ophthalmoplegia

Expression for Internuclear Ophthalmoplegia

Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for Internuclear Ophthalmoplegia

Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.43 HCRT MBP NF1 PSEN1
2 11.21 AQP4 MBP OMG
3 10.41 GBA HEXA

GO Terms for Internuclear Ophthalmoplegia

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 T cell activation involved in immune response GO:0002286 9.16 IFNB1 PSEN1
2 negative regulation of axonogenesis GO:0050771 8.96 OMG PSEN1
3 skin morphogenesis GO:0043589 8.62 GBA PSEN1

Sources for Internuclear Ophthalmoplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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