MCID: INT042
MIFTS: 40

Internuclear Ophthalmoplegia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

MalaCards integrated aliases for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:538
ICD10 32 H51.2
ICD9CM 34 378.86
MeSH 41 D015835
SNOMED-CT 64 49823009
UMLS 69 C0152134

Summaries for Internuclear Ophthalmoplegia

MalaCards based summary : Internuclear Ophthalmoplegia is related to multiple sclerosis and myelitis, and has symptoms including anomalies of divergence, spasm of conjugate gaze and ophthalmoplegia. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs 4-Aminopyridine and Potassium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and pons, and related phenotypes are behavior/neurological and hematopoietic system

Wikipedia : 72 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

Related Diseases for Internuclear Ophthalmoplegia

Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.4 AQP4 IFNB1 MBP MOG
2 myelitis 30.1 AQP4 MBP MOG
3 neuromyelitis optica 30.1 AQP4 HCRT MBP MOG
4 central pontine myelinolysis 10.4 AQP4 MBP
5 autoimmune encephalitis 10.4 HCRT LGI1
6 acute hemorrhagic leukoencephalitis 10.4 AQP4 MBP
7 transverse myelitis 10.4 AQP4 MBP
8 allergic encephalomyelitis 10.3 MBP MOG
9 head injury 10.3
10 chronic inflammatory demyelinating polyradiculoneuropathy 10.3 IFNB1 MBP
11 obstructive hydrocephalus 10.3 AQP4 NF1
12 mannosidosis, beta a, lysosomal 10.3 HEXA MBP
13 childhood disintegrative disease 10.3 HEXA LGI1 MBP
14 exotropia 10.3
15 lupus erythematosus 10.3
16 panencephalitis, subacute sclerosing 10.3 MBP MOG
17 traumatic brain injury 10.3 AQP4 MBP
18 systemic lupus erythematosus 10.3
19 ataxia and polyneuropathy, adult-onset 10.3
20 myasthenia gravis 10.2
21 myasthenia gravis congenital 10.2
22 spinal cord disease 10.2 AQP4 MBP MOG
23 optic neuritis 10.2 AQP4 MBP MOG
24 neuritis 10.2 AQP4 MBP MOG
25 encephalitis 10.2 AQP4 LGI1 MOG
26 neuroretinitis 10.2 AQP4 IFNB1 MOG
27 oculomotor nerve paralysis 10.2 KANTR MBP
28 supranuclear palsy, progressive, 1 10.2
29 cervicitis 10.2
30 meningitis 10.2
31 classic progressive supranuclear palsy syndrome 10.2
32 third cranial nerve disease 10.2 KANTR MBP
33 expressive language disorder 10.1 NF1 PSEN1
34 anterior spinal artery syndrome 10.1 KANTR MBP
35 tabes dorsalis 10.1 KANTR MBP
36 supranuclear ocular palsy 10.1
37 aneurysm 10.1
38 hyperhidrosis, gustatory 10.0 KANTR NF1
39 strabismus 10.0
40 aceruloplasminemia 10.0
41 ataxia-oculomotor apraxia 3 10.0
42 ptosis 10.0
43 neuronitis 10.0
44 vasculitis 10.0
45 glioma 10.0
46 neuromyelitis optica spectrum disorder 10.0
47 tuberculous meningitis 10.0
48 ideomotor apraxia 10.0 MBP PSEN1
49 balo concentric sclerosis 10.0 AQP4 IFNB1 MBP MOG
50 relapsing-remitting multiple sclerosis 10.0 AQP4 IFNB1 MBP MOG

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to Internuclear Ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

UMLS symptoms related to Internuclear Ophthalmoplegia:


anomalies of divergence, spasm of conjugate gaze, ophthalmoplegia

MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 MOG HCRT HEXA AQP4 CD55 LGI1
2 hematopoietic system MP:0005397 10.07 GKN2 MOG NF1 AQP4 IFNB1 CD55
3 growth/size/body region MP:0005378 10.06 GBA MBP MOG HCRT HEXA AQP4
4 homeostasis/metabolism MP:0005376 10.02 GBA MBP GKN2 HCRT HEXA AQP4
5 immune system MP:0005387 9.96 GBA GKN2 MOG AQP4 IFNB1 CD55
6 nervous system MP:0003631 9.85 MBP GBA MOG HCRT HEXA AQP4
7 normal MP:0002873 9.5 GBA MBP IFNB1 CXCR5 NF1 OMG
8 vision/eye MP:0005391 9.17 MBP MOG HEXA AQP4 LGI1 PSEN1

Drugs & Therapeutics for Internuclear Ophthalmoplegia

Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 2 504-24-5 1727
2 Potassium Channel Blockers Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis Recruiting NCT02391961 Phase 2 Dalfampridine;Placebo

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

Anatomical Context for Internuclear Ophthalmoplegia

MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

38
Eye, Brain, Pons, Testes

Publications for Internuclear Ophthalmoplegia

Articles related to Internuclear Ophthalmoplegia:

(show top 50) (show all 273)
# Title Authors Year
1
Isolated bilateral internuclear ophthalmoplegia due to lacunar infarction. ( 29170848 )
2017
2
A rare cause for visual symptoms in multiple sclerosis: posterior internuclear ophthalmoplegia of Lutz, a historical misnomer. ( 28194531 )
2017
3
Can Wernekink commissure syndrome and wall-eyed bilateral internuclear ophthalmoplegia be ascribed to neuromyelitis optica spectrum disorder? ( 28681309 )
2017
4
Isolated Internuclear Ophthalmoplegia After Massive Supratentorial Epidural Hematoma: A Case Report and Review of the Literature. ( 28143728 )
2017
5
Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review. ( 28774543 )
2017
6
Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 29142084 )
2017
7
Post-operative unilateral internuclear ophthalmoplegia following basilar pneumocephalus after resection of C1 intradural extramedullary tumor. ( 28558345 )
2017
8
Internuclear Ophthalmoplegia Secondary to Cocaine Abuse. ( 28265477 )
2017
9
Internuclear Ophthalmoplegia ( 28722999 )
2017
10
Saccadic hypermetria on abduction of the ipsilesional eye in internuclear ophthalmoplegia. ( 28431591 )
2017
11
Preferential Impairment of the Contralesional Posterior Semicircular Canal in Internuclear Ophthalmoplegia. ( 29018402 )
2017
12
Bilateral internuclear ophthalmoplegia following head trauma. ( 28440256 )
2017
13
Unilateral internuclear ophthalmoplegia, strabismus and transient torsional nystagmus in focal pontine infarction. ( 27448548 )
2016
14
Visualisation of the medial longitudinal fasciculus using fibre tractography in multiple sclerosis patients with internuclear ophthalmoplegia. ( 26787313 )
2016
15
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. ( 26944331 )
2016
16
Internuclear ophthalmoplegia. ( 27927777 )
2016
17
Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction. ( 27567293 )
2016
18
Bilateral Internuclear Ophthalmoplegia as a Presenting Manifestation of Primary SjAPgren's Syndrome. ( 27928415 )
2016
19
Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction. ( 26995360 )
2016
20
A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging. ( 27857923 )
2016
21
Wall-eyed bilateral internuclear ophthalmoplegia. ( 26053827 )
2015
22
Unilateral internuclear ophthalmoplegia with upbeat nystagmus from ischemic origin: evidence for the paramedian tract neurons as a vertical neural integrator? ( 26550407 )
2015
23
Internuclear Ophthalmoplegia Associated with Anti-TNFI+ Medication. ( 25790247 )
2015
24
Large basilar tip aneurysm causing anterior internuclear ophthalmoplegia. ( 25670869 )
2015
25
Gaze palsy and exotropia in internuclear ophthalmoplegia. ( 25911021 )
2015
26
Wall-eyed bilateral internuclear ophthalmoplegia: review of pathogenesis, diagnosis, prognosis and management. ( 25308307 )
2014
27
Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients. ( 24599322 )
2014
28
Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. ( 24770935 )
2014
29
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. ( 24870222 )
2014
30
Brainstem Infarction with Wall-eyed Bilateral Internuclear Ophthalmoplegia Syndrome and Vertical One-and-a-Half Syndrome. ( 24424330 )
2014
31
Pontine infarction responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome. ( 29443142 )
2014
32
Periprocedural stroke presenting as isolated unilateral internuclear ophthalmoplegia. ( 25114281 )
2014
33
Jerky seesaw nystagmus with internuclear ophthalmoplegia as the presenting finding in systemic lupus erythematosus. ( 25455550 )
2014
34
Unilateral Internuclear Ophthalmoplegia as an Isolated Presentation of Metastatic Melanoma. ( 25232840 )
2014
35
Evolution of symmetric upbeat into dissociated torsional-upbeat nystagmus in internuclear ophthalmoplegia. ( 23664561 )
2013
36
An unusual aetiology for internuclear ophthalmoplegia. ( 23737577 )
2013
37
Reversible cortical blindness and internuclear ophthalmoplegia after neurosurgical operation: case report and review of the literature. ( 23042139 )
2013
38
Bilateral internuclear ophthalmoplegia associated with pediatric brain tumor progression: a case series and review of the literature. ( 24048548 )
2013
39
Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct. ( 23830476 )
2013
40
Pediatric internuclear ophthalmoplegia. ( 23470988 )
2013
41
Images in clinical medicine. Bilateral internuclear ophthalmoplegia in multiple sclerosis. ( 23323922 )
2013
42
Motion diplopia in an isolated unilateral internuclear ophthalmoplegia: a new neurological symptom? ( 22790327 )
2013
43
Ocular vestibular evoked myogenic potentials to head tap and cervical vestibular evoked myogenic potentials to air-conducted sounds in isolated internuclear ophthalmoplegia. ( 24238926 )
2013
44
Jerky see-saw nystagmus in internuclear ophthalmoplegia from a lower pontine lesion. ( 23166883 )
2012
45
Rapid reversal of wall-eyed bilateral internuclear ophthalmoplegia. ( 22410451 )
2012
46
Neurocysticercosis presenting as isolated wall-eyed monocular internuclear ophthalmoplegia with contraversive ocular tilt reaction. ( 22346205 )
2012
47
Unilateral internuclear ophthalmoplegia after minor head injury. ( 22461944 )
2012
48
Bilateral internuclear ophthalmoplegia with unilateral horizontal gaze paresis. ( 22728510 )
2012
49
Complete bilateral horizontal internuclear ophthalmoplegia as a sign of multiple sclerosis relapse. ( 23040719 )
2012
50
A small pontine infarct on DWI as a lesion responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome. ( 21655962 )
2012

Variations for Internuclear Ophthalmoplegia

Expression for Internuclear Ophthalmoplegia

Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for Internuclear Ophthalmoplegia

Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 HCRT MBP NF1 PSEN1
2 11.21 AQP4 MBP OMG
3 10.41 GBA HEXA

GO Terms for Internuclear Ophthalmoplegia

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation involved in immune response GO:0002286 9.16 IFNB1 PSEN1
2 negative regulation of axonogenesis GO:0050771 8.96 OMG PSEN1
3 skin morphogenesis GO:0043589 8.62 GBA PSEN1

Sources for Internuclear Ophthalmoplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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