MCID: INT042
MIFTS: 36

Internuclear Ophthalmoplegia malady

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

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Aliases & Descriptions for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:538
ICD1027 H51.2
SNOMED-CT59 49823009
ICD9CM29 378.86
MeSH36 D015835
UMLS65 C0152134

Summaries for Internuclear Ophthalmoplegia

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Wikipedia:68 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

MalaCards based summary: Internuclear Ophthalmoplegia is related to nemaline myopathy and neutropenia. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways are Other glycan degradation and Spinal Cord Injury. Affiliated tissues include eye, liver and lung, and related mouse phenotypes are vision/eye and normal.

Related Diseases for Internuclear Ophthalmoplegia

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Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1nemaline myopathy30.7AQP4, MBP
2neutropenia30.5AQP4, HCRT, MBP
3breast cancer10.4
4treponema infection10.4AQP4, MBP
5acral lentiginous melanoma10.4AQP4, MBP
6causalgia10.4AQP4, MBP
7arthritis10.4
8prostatitis10.4
9myopathy10.4
10thyroiditis10.4
11neuronitis10.4
12immature cataract10.4AQP4, MBP
133-hydroxyacyl-coa dehydrogenase deficiency10.3HEXA, MBP
14schizophrenia10.3
15rheumatoid arthritis10.3
16lung cancer10.3
17prostate cancer10.3
18silver-russell syndrome10.3
19adult respiratory distress syndrome10.3
20hepatitis10.3
21lymphoma10.3
22hyperandrogenism10.3
23dental caries10.3
24antiphospholipid syndrome10.3
25retinitis10.3
26pneumonia10.3
27periodontitis10.3
28endotheliitis10.3
29diplegia of upper limb10.3AQP4, HCRT
30lipid-rich carcinoma10.3AQP4, MBP
31childhood pilocytic astrocytoma10.3MBP, NF1
32malignant hypertensive renal disease10.3AQP4, IFNB1
33encephalitozoonosis10.2GBA, MBP
34active cochleovestibular meniere's disease10.2HEXA, LGI1, MBP
35metanephric adenoma10.2AQP4, HCRT, MBP
36inflammatory spondylopathy10.2AQP4, HCRT, MBP
37neurogenic bowel10.2MBP, PSEN1
38reproductive organ cancer10.2GBA, HEXA
39rectal disease10.2HCRT, MBP
40atrial fibrillation10.1MBP, PSEN1
41primary progressive multiple sclerosis10.1IFNB1, MBP
42systemic lupus erythematosus10.1
43malaria10.1
44esophageal cancer10.1
45myelodysplastic syndrome10.1
46cystic fibrosis10.1
47avascular necrosis of the femoral head10.1
48tay-sachs disease10.1
49pancreatic cancer10.1
50cryptorchidism10.1

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to internuclear ophthalmoplegia

Symptoms for Internuclear Ophthalmoplegia

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Drugs & Therapeutics for Internuclear Ophthalmoplegia

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Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DalfampridineapprovedPhase 262504-24-51727
Synonyms:
.gamma.-Aminopyridine
275875_ALDRICH
36687_FLUKA
36687_RIEDEL
4 AP
4 Aminopyridine
4 Aminopyridine Sustained Release
4-AP
4-Aminopyridine
4-Aminopyridine 10
4-Aminopyridine Sustained Release
4-Pyridinamine
4-Pyridylamine
4-aminopyridine
5-22-09-00106 (Beilstein Handbook Reference)
504-24-5
A 0152
A0414
A78403_ALDRICH
AB1004971
AC-907/25014071
AC1L1C3R
AC1Q52BM
AI3-52547
AKOS000119896
Amaya
Amino-4 pyridine
Amino-4-Pyridine
Ampydin
Ampyra
Avitrol
Avitrol 200
BB_SC-6974
BRN 0105782
BSPBio_001562
Bio1_000353
Bio1_000842
Bio1_001331
Bio2_000282
Bio2_000762
C13728
C5H6N2
CHEBI:34385
CHEMBL284348
CID1727
Caswell No. 038
Compound 1861
D015761
D04127
Dalfampridine
DivK1c_000572
EINECS 207-987-9
EL-970
EPA Pesticide Chemical Code 069201
EU-0100032
FT-0083754
Fampridina
Fampridine
Fampridine (USAN/INN)
Fampridine SR
Fampridine [USAN:INN]
Fampridine-PR
Fampridine-SR
Fampridinum
Fampyra
HC150041
HMS1361O04
HMS1791O04
HMS1921H15
HMS1989O04
HMS2092F05
HMS501M14
HSDB 6037
IDI1_000572
IDI1_034032
InChI=1/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7
 
KBio1_000572
KBio2_000282
KBio2_000635
KBio2_002850
KBio2_003203
KBio2_005418
KBio2_005771
KBio3_000563
KBio3_000564
KBio3_001888
KBioGR_000282
KBioGR_001505
KBioSS_000282
KBioSS_000635
LS-130202
Lopac-A-0152
Lopac0_000032
MLS000069400
Mi-W-3
MolPort-000-146-022
N07XX07
NCGC00015009-01
NCGC00015009-03
NCGC00015009-12
NCGC00024890-01
NCGC00024890-02
NCGC00024890-03
NCGC00024890-04
NCGC00024890-05
NCGC00024890-06
NCGC00024890-07
NCGC00024890-08
NCGC00024890-09
NCGC00024890-10
NINDS_000572
NSC 15041
NSC15041
Neurelan
Neurelan (TN)
P-Aminopyridine
PYRIDINE,4-AMINO
Philips 1861
Phillips 1861
Pimadin (free base)
Prc 1237
Pymadin
Pymadine
RCRA waste no. P008
SDCCGMLS-0066228.P001
SMR000058211
SPBio_001486
SPECTRUM1501130
STK298717
Spectrum2_001413
Spectrum3_000914
Spectrum4_001013
Spectrum5_001501
Spectrum_000155
Sustained Release, 4-Aminopyridine
TL8003344
Tocris-0940
UNII-BH3B64OKL9
UPCMLD-DP125
UPCMLD-DP125:001
VMI 10-3
VMI 103
VMI-10-3
VMI-103
VMI103
WLN: T6NJ DZ
[J.Pharmacol.Exp.Ther. 275:864 (1995)]
gamma-Aminopyridine
nchem.892-comp4
p-Aminopyridine
p-Aminopyridine [UN2671] [Poison]
p-Aminopyridine [UN2671] [Poison]
pyridin-4-amine
pyridin-4-ylamine
2Potassium Channel BlockersPhase 2151

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple SclerosisRecruitingNCT02391961Phase 2

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

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Anatomical Context for Internuclear Ophthalmoplegia

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MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

33
Eye, Liver, Lung, Prostate, T cells, Testes, Thyroid

Animal Models for Internuclear Ophthalmoplegia or affiliated genes

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MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4AQP4, HEXA, LGI1, MBP, NF1, PSEN1
2MP:00028738.2GBA, IFNB1, MBP, NF1, OMG, PSEN1
3MP:00053867.3AQP4, CD55, GBA, HCRT, HEXA, LGI1
4MP:00053977.1AQP4, CD55, CXCR5, GBA, IFNB1, MBP
5MP:00036317.0AQP4, GBA, HCRT, HEXA, IFNB1, LGI1
6MP:00053766.8AQP4, GBA, HCRT, HEXA, IFNB1, MBP

Publications for Internuclear Ophthalmoplegia

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Articles related to Internuclear Ophthalmoplegia:

(show top 50)    (show all 252)
idTitleAuthorsYear
1
Autoimmune response to PARP and BRCA1/BRCA2 in cancer. (25865228)
2015
2
Expression of G1/S-cyclins and cyclin-dependent kinase inhibitors in actinic keratosis and squamous cell carcinoma. (26349899)
2015
3
Dental implants and osteomyelitis in a patient with osteopetrosis. (25126646)
2014
4
Esthetic restoration in progressive hemifacial atrophy (Romberg disease): structural fat grafting versus local/free flaps. (24769615)
2014
5
YKL-40 and alcoholic liver and pancreas damage and disease in 86,258 individuals from the general population: cohort and mendelian randomization studies. (25225167)
2014
6
Use of the UPOINT phenotype system in treating Chinese patients with chronic prostatitis/chronic pelvic pain syndrome: a prospective study. (25248659)
2014
7
Is methemoglobin an inert bystander, biomarker or a mediator of oxidative stress-The example of anemia? (24024138)
2013
8
A comparison between the fluocinolone acetonide (Retisert) and dexamethasone (Ozurdex) intravitreal implants in uveitis. (23297752)
2013
9
MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1I^-induced catabolic effects in human articular chondrocytes. (23611898)
2013
10
The use of a low dose hydrocortisone to prevent pulmonary embolism in patients with multiple trauma. (23605143)
2013
11
Hepatitis B virus infection and fatty liver in the general population. (22027575)
2012
12
Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in Japanese. (22402017)
2012
13
Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosis. (22360692)
2012
14
Large sacrococcygeal teratoma hindering vaginal delivery attempted at home. (22866184)
2012
15
Immune reconstitution--the footing of Chinese medicine treatment for acquired immunodeficiency syndrome. (21611894)
2011
16
Tumor necrosis factor-receptor 2 and TROY gene expression patterns in cutaneous squamous cell carcinoma in a Tunisian population. (22057614)
2011
17
Clinical spectrum and molecular pathophysiology of Shwachman-Diamond syndrome. (21124213)
2010
18
Nicotine promotes cardiomyocyte apoptosis via oxidative stress and altered apoptosis-related gene expression. (20339300)
2010
19
Inherited thrombophilia and preeclampsia: is the evidence beginning to congeal? (19185098)
2009
20
Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor. (18675787)
2008
21
Autophosphorylated residues involved in the regulation of human chk2 in vitro. (18538787)
2008
22
Targeting of the 5-HT1A serotonin receptor to neuronal dendrites is mediated by Yif1B. (18685031)
2008
23
Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. (18385090)
2008
24
Merkel cell carcinoma: molecular pathogenesis, clinical features and therapy. (19000060)
2008
25
Oncocytic mucoepidermoid carcinoma of a submandibular gland: a case report and review of the literature. (17331704)
2007
26
Interleukin 1 receptor antagonist therapy-induced thrombocytopenia in adult onset Still's disease. (17407250)
2007
27
The prevalence and prognostic value of BRAF mutation in thyroid cancer. (17717450)
2007
28
Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. (17721310)
2007
29
Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons. (17114052)
2006
30
Imported Plasmodium falciparum malaria: are patients originating from disease-endemic areas less likely to develop severe disease? A prospective, observational study. (17172392)
2006
31
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. (16227588)
2005
32
Histone deacetylase is a target of valproic acid-mediated cellular differentiation. (14871841)
2004
33
Relation between the angiotensin-converting enzyme insertion/deletion polymorphism and blood pressure in Japanese male subjects. (14504630)
2003
34
Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo. (12520531)
2003
35
Molecular basis for the loss of CD28 expression in senescent T cells. (12324461)
2002
36
Thoracoscopically managed parathyroid adenoma in the upper anterior mediastinum. (11822866)
2001
37
Retinoic acid homeostasis: retinoic acid regulates liver retinol esterification as well as its own catabolic oxidation in liver. (11766909)
2001
38
Examination of factors affecting efficacy and adverse effect, for the retrospective study of vancomycin hydrochloride (VCM)]. (11523122)
2001
39
Acute quadriplegia in a 34-year-old man. (11142462)
2000
40
American Chemical Society 217th National Meeting division of Medicinal Chemistry general session. 21-25 March 1999, Anaheim, CA, USA. (16127601)
1999
41
The in vivo association of BiP with newly synthesized proteins is dependent on the rate and stability of folding and not simply on the presence of sequences that can bind to BiP. (9885241)
1999
42
Interferon-alpha: evolving therapy for AIDS-associated Kaposi's sarcoma. (9568721)
1998
43
An epithelioid cell type of amelanotic melanoma of the pinna in a Fischer-344 rat: a case report. (8992617)
1996
44
Astrocyte membrane Na+, K(+)-ATPase and Mg(2+)-ATPase as targets of organic solvent impact. (7475975)
1995
45
NBQX, a competitive non-NMDA receptor antagonist, reduces degeneration due to focal spinal cord ischemia. (7925838)
1994
46
Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. (1443986)
1992
47
Plasma concentrations of regulatory peptides in obesity following modified sham feeding (MSF) and a liquid test meal. (1349761)
1992
48
Subependymoma of the lateral ventricle--case report. (1723163)
1991
49
Transient cortical blindness and occipital seizures with cyclosporine toxicity. (2922804)
1989
50
Central serotonergic neurons and experimental neurogenic and renal hypertension in the rabbit. (1077778)
1975

Variations for Internuclear Ophthalmoplegia

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Expression for genes affiliated with Internuclear Ophthalmoplegia

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Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for genes affiliated with Internuclear Ophthalmoplegia

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Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7GBA, HEXA
29.7AQP4, MBP, OMG

GO Terms for genes affiliated with Internuclear Ophthalmoplegia

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Cellular components related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:00057919.5HCRT, PSEN1

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sphingolipid metabolic processGO:00066659.9GBA, HEXA
2T cell activation involved in immune responseGO:00022869.8IFNB1, PSEN1
3negative regulation of protein kinase activityGO:00064699.4NF1, PSEN1
4cerebral cortex developmentGO:00219879.3NF1, PSEN1
5skin morphogenesisGO:00435899.1GBA, PSEN1

Sources for Internuclear Ophthalmoplegia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet