MCID: INT042
MIFTS: 36

Internuclear Ophthalmoplegia malady

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

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Aliases & Descriptions for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 11 13 66

Classifications:



External Ids:

Disease Ontology11 DOID:538
ICD1028 H51.2
SNOMED-CT60 49823009
ICD9CM30 378.86
MeSH37 D015835

Summaries for Internuclear Ophthalmoplegia

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Wikipedia:69 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

MalaCards based summary: Internuclear Ophthalmoplegia is related to myelitis and hepatic osteogenic sarcoma, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomaly of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways are Other glycan degradation and Spinal Cord Injury. Affiliated tissues include eye, brain and pons, and related mouse phenotypes are vision/eye and hematopoietic system.

Related Diseases for Internuclear Ophthalmoplegia

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Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1myelitis30.1AQP4, IFNB1, MBP
2hepatic osteogenic sarcoma10.7AQP4, MBP
3ovarian papillary cystadenoma10.6AQP4, MBP
4lens disease10.6AQP4, MBP
5neurilemmoma10.6AQP4, MBP
63-hydroxyacyl-coa dehydrogenase deficiency10.5HEXA, MBP
7transsexualism10.4LGI1, PSEN1
8active vestibular meniere's disease10.4HEXA, LGI1, MBP
9measles10.4AQP4, HCRT
10endobronchial lipoma10.4AQP4, IFNB1
11compartment syndrome10.4MBP, NF1
12newborn respiratory distress syndrome10.4AQP4, HCRT, MBP
13bullous retinoschisis10.4AQP4, HCRT, MBP
14head injury10.3
15exotropia10.3
16lupus erythematosus10.3
17rheumatic disease10.3HCRT, PSEN1
18chandler syndrome10.3KANTR, MBP
19adenosquamous breast carcinoma10.3KANTR, MBP
20spleen cancer10.3KANTR, MBP
21systemic lupus erythematosus10.3
22ataxia10.3
23interstitial emphysema10.3KANTR, MBP
24myasthenia gravis10.2
25hypothalamic disease10.2GBA, HEXA
26noninfectious dermatoses of eyelid10.2AQP4, MBP
27nasal cavity inverting papilloma10.2MBP, PSEN1
28cogan-reese syndrome10.2AQP4, IFNB1, MBP
29cervicitis10.2
30meningitis10.2
31infant gynecomastia10.2KANTR, NF1
32kernicterus10.2AQP4, IFNB1, MBP
33proximal symphalangism10.2IFNB1, MBP, OMG
34adenomyoma of uterine corpus10.2MBP, NF1
35aneurysm10.1
36multiple sclerosis, disease progression, modifier of10.1AQP4, IFNB1, MBP
37diffuse alopecia areata10.1KANTR, PSEN1
38peritoneal benign neoplasm10.1KANTR, NF1
39lymphoepithelioma-like carcinoma10.1AQP4, KANTR, MBP
40balanitis10.1KANTR, PSEN1
41progressive relapsing multiple sclerosis10.0IFNB1, MBP
42cerebellar ataxia10.0
43neuromyelitis optica10.0
44ptosis10.0
45strabismus10.0
46neuronitis10.0
47vasculitis10.0
48glioma10.0
49tuberculous meningitis10.0
50apraxia10.0KANTR, PSEN1

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to internuclear ophthalmoplegia

Symptoms for Internuclear Ophthalmoplegia

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UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomaly of divergence

Drugs & Therapeutics for Internuclear Ophthalmoplegia

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Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
4-AminopyridinePhase 267504-24-51727
Synonyms:
.gamma.-Aminopyridine
275875_ALDRICH
36687_FLUKA
36687_RIEDEL
4 AP
4 Aminopyridine
4 Aminopyridine Sustained Release
4-AP
4-Aminopyridine
4-Aminopyridine 10
4-Aminopyridine Sustained Release
4-Pyridinamine
4-Pyridylamine
4-aminopyridine
5-22-09-00106 (Beilstein Handbook Reference)
504-24-5
A 0152
A0414
A78403_ALDRICH
AB1004971
AC-907/25014071
AC1L1C3R
AC1Q52BM
AI3-52547
AKOS000119896
Amaya
Amino-4 pyridine
Amino-4-Pyridine
Ampydin
Ampyra
Avitrol
Avitrol 200
BB_SC-6974
BRN 0105782
BSPBio_001562
Bio1_000353
Bio1_000842
Bio1_001331
Bio2_000282
Bio2_000762
C13728
C5H6N2
CHEBI:34385
CHEMBL284348
CID1727
Caswell No. 038
Compound 1861
D015761
D04127
Dalfampridine
DivK1c_000572
EINECS 207-987-9
EL-970
EPA Pesticide Chemical Code 069201
EU-0100032
FT-0083754
Fampridina
Fampridine
Fampridine (USAN/INN)
Fampridine SR
Fampridine [USAN:INN]
Fampridine-PR
Fampridine-SR
Fampridinum
HC150041
HMS1361O04
HMS1791O04
HMS1921H15
HMS1989O04
HMS2092F05
HMS501M14
HSDB 6037
IDI1_000572
IDI1_034032
InChI=1/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7
KBio1_000572
 
KBio2_000282
KBio2_000635
KBio2_002850
KBio2_003203
KBio2_005418
KBio2_005771
KBio3_000563
KBio3_000564
KBio3_001888
KBioGR_000282
KBioGR_001505
KBioSS_000282
KBioSS_000635
LS-130202
Lopac-A-0152
Lopac0_000032
MLS000069400
Mi-W-3
MolPort-000-146-022
N07XX07
NCGC00015009-01
NCGC00015009-03
NCGC00015009-12
NCGC00024890-01
NCGC00024890-02
NCGC00024890-03
NCGC00024890-04
NCGC00024890-05
NCGC00024890-06
NCGC00024890-07
NCGC00024890-08
NCGC00024890-09
NCGC00024890-10
NINDS_000572
NSC 15041
NSC15041
Neurelan
Neurelan (TN)
P-Aminopyridine
PYRIDINE,4-AMINO
Philips 1861
Phillips 1861
Pimadin (free base)
Prc 1237
Pymadin
Pymadine
RCRA waste no. P008
SDCCGMLS-0066228.P001
SMR000058211
SPBio_001486
SPECTRUM1501130
STK298717
Spectrum2_001413
Spectrum3_000914
Spectrum4_001013
Spectrum5_001501
Spectrum_000155
Sustained Release, 4-Aminopyridine
TL8003344
Tocris-0940
UNII-BH3B64OKL9
UPCMLD-DP125
UPCMLD-DP125:001
VMI 10-3
VMI 103
VMI-10-3
VMI-103
VMI103
WLN: T6NJ DZ
[J.Pharmacol.Exp.Ther. 275:864 (1995)]
gamma-Aminopyridine
nchem.892-comp4
p-Aminopyridine
p-Aminopyridine [UN2671] [Poison]
p-Aminopyridine [UN2671] [Poison]
pyridin-4-amine
pyridin-4-ylamine

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple SclerosisRecruitingNCT02391961Phase 2

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

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Anatomical Context for Internuclear Ophthalmoplegia

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MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

34
Eye, Brain, Pons, Testes

Animal Models for Internuclear Ophthalmoplegia or affiliated genes

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MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4AQP4, HEXA, LGI1, MBP, NF1, PSEN1
2MP:00053977.6AQP4, CD55, CXCR5, GBA, IFNB1, MBP
3MP:00053767.3AQP4, GBA, HCRT, HEXA, IFNB1, MBP
4MP:00036317.3AQP4, GBA, HCRT, HEXA, IFNB1, LGI1
5MP:00053867.2AQP4, CD55, GBA, HCRT, HEXA, LGI1

Publications for Internuclear Ophthalmoplegia

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Articles related to Internuclear Ophthalmoplegia:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. (26944331)
2016
2
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. (24870222)
2014
3
Bilateral internuclear ophthalmoplegia associated with pediatric brain tumor progression: a case series and review of the literature. (24048548)
2013
4
Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct. (23830476)
2013
5
Pediatric internuclear ophthalmoplegia. (23470988)
2013
6
Motion diplopia in an isolated unilateral internuclear ophthalmoplegia: a new neurological symptom? (22790327)
2013
7
Evolution of symmetric upbeat into dissociated torsional-upbeat nystagmus in internuclear ophthalmoplegia. (23664561)
2013
8
Rapid reversal of wall-eyed bilateral internuclear ophthalmoplegia. (22410451)
2012
9
Patterns of dissociate torsional-vertical nystagmus in internuclear ophthalmoplegia. (21951004)
2011
10
Pseudo-internuclear ophthalmoplegia as a sign of overlapping myasthenia gravis in a patient with 'intractable' hypothyroidism. (20046005)
2010
11
Internuclear ophthalmoplegia. (16606784)
2006
12
Reversible bilateral internuclear ophthalmoplegia associated with FK506. (15090580)
2004
13
Bilateral internuclear ophthalmoplegia following minor head trauma. (12554035)
2003
14
Prognosis of ischemic internuclear ophthalmoplegia. (12208716)
2002
15
Internuclear ophthalmoplegia as the first sign of neuroborreliosis. (12420716)
2002
16
Internuclear ophthalmoplegia associated with transient torsional nystagmus. (12189654)
2002
17
Herpes zoster vasculitis presenting as giant cell arteritis with bilateral internuclear ophthalmoplegia. (12470766)
2002
18
Internuclear ophthalmoplegia with skew deviation. Two cases with an isolated circumscribed lesion of the medial longitudinal fasciculus. (11096232)
2000
19
Partial unilateral third nerve palsy and bilateral internuclear ophthalmoplegia: an unusual presentation of multiple sclerosis. (11040928)
2000
20
Internuclear ophthalmoplegia in systemic lupus erythematosus. (9872478)
1998
21
Pontine lesion of the abducens fasciculus producing so-called posterior internuclear ophthalmoplegia. (9018039)
1997
22
Toxic internuclear ophthalmoplegia related to antiobesity treatment. (1477455)
1992
23
Abduction nystagmus in internuclear ophthalmoplegia. (1455982)
1992
24
Bilateral internuclear ophthalmoplegia in a patient with Wernicke's encephalopathy. (1629372)
1992
25
Combined trochlear nerve palsy and internuclear ophthalmoplegia. (1728255)
1992
26
Internuclear ophthalmoplegia in acquired immunodeficiency syndrome. (2802452)
1989
27
Internuclear ophthalmoplegia in tuberculous meningitis. (2781611)
1989
28
Internuclear ophthalmoplegia in pernicious anemia. (2495069)
1989
29
Vertical vestibulo-ocular reflex, smooth pursuit and eye-head tracking dysfunction in internuclear ophthalmoplegia. (3208059)
1988
30
Unilateral internuclear ophthalmoplegia, migraine, and supratentorial arteriovenous malformation. (3618721)
1987
31
Internuclear ophthalmoplegia. (3759887)
1986
32
Anterior internuclear ophthalmoplegia. (4055693)
1985
33
Internuclear ophthalmoplegia in tuberculous meningitis. A report of two cases. (6468455)
1984
34
Anterior internuclear ophthalmoplegia. (6526802)
1984
35
Bilateral internuclear ophthalmoplegia from doxepin overdose. (6538026)
1984
36
Bilateral internuclear ophthalmoplegia reversed by naloxone. (6830474)
1983
37
Internuclear ophthalmoplegia in patients with toxic coma frequency, prognostic value, diagnostic significance. (6655778)
1983
38
Internuclear ophthalmoplegia. (6675807)
1983
39
Internuclear ophthalmoplegia in Fabry's disease. (6794412)
1981
40
Internuclear ophthalmoplegia: recovery and plasticity. (7440105)
1980
41
Experimental internuclear ophthalmoplegia. (403929)
1977
42
An electrooculographic study of internuclear ophthalmoplegia. (617577)
1977
43
Internuclear ophthalmoplegia in progressive supranuclear palsy. (1159448)
1975
44
Abducting nystagmus in the medial longitudinal fasciculus (MLF) syndrome (internuclear ophthalmoplegia (INO)). (4718627)
1973
45
Vestibular influences on internuclear ophthalmoplegia. (5100343)
1971
46
Internuclear ophthalmoplegia, typical and atypical. (5478883)
1970
47
Unilateral internuclear ophthalmoplegia. Report of a case including pathology. (5937495)
1966
48
Myasthenic psuedo-internuclear ophthalmoplegia. (5903821)
1966
49
Internuclear ophthalmoplegia; a review of fifty-eight cases. (13636562)
1959
50
Unilateral internuclear ophthalmoplegia; a report of seven clinical cases and the postmortem findings in one case. (14788115)
1950

Variations for Internuclear Ophthalmoplegia

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Expression for genes affiliated with Internuclear Ophthalmoplegia

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Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for genes affiliated with Internuclear Ophthalmoplegia

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Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8GBA, HEXA
29.7AQP4, MBP, OMG

GO Terms for genes affiliated with Internuclear Ophthalmoplegia

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Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of MAP kinase activityGO:00434079.7GBA, NF1
2T cell activation involved in immune responseGO:00022869.7IFNB1, PSEN1
3skin morphogenesisGO:00435899.5GBA, PSEN1
4negative regulation of axonogenesisGO:00507719.2MBP, OMG, PSEN1

Sources for Internuclear Ophthalmoplegia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet