MCID: INT042
MIFTS: 41

Internuclear Ophthalmoplegia malady

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

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Aliases & Descriptions for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:538
ICD1027 H51.2
SNOMED-CT59 49823009
ICD9CM29 378.86
MeSH36 D015835
UMLS65 C0152134

Summaries for Internuclear Ophthalmoplegia

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Wikipedia:68 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

MalaCards based summary: Internuclear Ophthalmoplegia is related to ophthalmoplegia and treponema infection, and has symptoms including anomaly of divergence, spasm of conjugate gaze and ophthalmoplegia. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways are Other glycan degradation and Spinal Cord Injury. Affiliated tissues include eye, thyroid and liver, and related mouse phenotypes are vision/eye and normal.

Related Diseases for Internuclear Ophthalmoplegia

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Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1ophthalmoplegia11.1
2treponema infection10.6AQP4, MBP
3acral lentiginous melanoma10.6AQP4, MBP
4causalgia10.6AQP4, MBP
5immature cataract10.6AQP4, MBP
6nemaline myopathy10.5AQP4, MBP
73-hydroxyacyl-coa dehydrogenase deficiency10.5HEXA, MBP
8diplegia of upper limb10.4AQP4, HCRT
9lipid-rich carcinoma10.4AQP4, MBP
10childhood pilocytic astrocytoma10.4MBP, NF1
11malignant hypertensive renal disease10.4AQP4, IFNB1
12encephalitozoonosis10.4GBA, MBP
13head injury10.4
14exotropia10.3
15lupus erythematosus10.3
16active cochleovestibular meniere's disease10.3HEXA, LGI1, MBP
17metanephric adenoma10.3AQP4, HCRT, MBP
18neutropenia10.3AQP4, HCRT, MBP
19inflammatory spondylopathy10.3AQP4, HCRT, MBP
20systemic lupus erythematosus10.3
21ataxia10.3
22neurogenic bowel10.3MBP, PSEN1
23myasthenia gravis10.2
24reproductive organ cancer10.2GBA, HEXA
25rectal disease10.2HCRT, MBP
26atrial fibrillation10.2MBP, PSEN1
27primary progressive multiple sclerosis10.2IFNB1, MBP
28cervicitis10.2
29meningitis10.2
30cogan syndrome10.2AQP4, IFNB1, MBP
31inverted transitional papilloma10.2MBP, PSEN1
32pupil disease10.1AQP4, IFNB1, MBP
33progressive relapsing multiple sclerosis10.1IFNB1, MBP, OMG
34jejunal somatostatinoma10.1AQP4, IFNB1, MBP
35aneurysm10.1
36multiple sclerosis, disease progression, modifier of10.1AQP4, IFNB1, MBP
37cellular schwannoma10.1MBP, NF1
38cerebellar ataxia10.1
39neuromyelitis optica10.1
40ptosis10.1
41neuronitis10.1
42vasculitis10.1
43glioma10.1
44tuberculous meningitis10.1
45eczematous dermatitis of eyelid10.0AQP4, MBP
46mood disorder10.0GBA, HEXA
47split hand foot malformation10.0GBA, NF1
48chronic inflammatory demyelinating polyneuropathy9.9
49hydrocephalus9.9
50african tick-bite fever9.9

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to internuclear ophthalmoplegia

Symptoms for Internuclear Ophthalmoplegia

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UMLS symptoms related to Internuclear Ophthalmoplegia:


anomaly of divergence, spasm of conjugate gaze, ophthalmoplegia

Drugs & Therapeutics for Internuclear Ophthalmoplegia

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Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DalfampridineapprovedPhase 262504-24-51727
Synonyms:
.gamma.-Aminopyridine
275875_ALDRICH
36687_FLUKA
36687_RIEDEL
4 AP
4 Aminopyridine
4 Aminopyridine Sustained Release
4-AP
4-Aminopyridine
4-Aminopyridine 10
4-Aminopyridine Sustained Release
4-Pyridinamine
4-Pyridylamine
4-aminopyridine
5-22-09-00106 (Beilstein Handbook Reference)
504-24-5
A 0152
A0414
A78403_ALDRICH
AB1004971
AC-907/25014071
AC1L1C3R
AC1Q52BM
AI3-52547
AKOS000119896
Amaya
Amino-4 pyridine
Amino-4-Pyridine
Ampydin
Ampyra
Avitrol
Avitrol 200
BB_SC-6974
BRN 0105782
BSPBio_001562
Bio1_000353
Bio1_000842
Bio1_001331
Bio2_000282
Bio2_000762
C13728
C5H6N2
CHEBI:34385
CHEMBL284348
CID1727
Caswell No. 038
Compound 1861
D015761
D04127
Dalfampridine
DivK1c_000572
EINECS 207-987-9
EL-970
EPA Pesticide Chemical Code 069201
EU-0100032
FT-0083754
Fampridina
Fampridine
Fampridine (USAN/INN)
Fampridine SR
Fampridine [USAN:INN]
Fampridine-PR
Fampridine-SR
Fampridinum
Fampyra
HC150041
HMS1361O04
HMS1791O04
HMS1921H15
HMS1989O04
HMS2092F05
HMS501M14
HSDB 6037
IDI1_000572
IDI1_034032
InChI=1/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7
 
KBio1_000572
KBio2_000282
KBio2_000635
KBio2_002850
KBio2_003203
KBio2_005418
KBio2_005771
KBio3_000563
KBio3_000564
KBio3_001888
KBioGR_000282
KBioGR_001505
KBioSS_000282
KBioSS_000635
LS-130202
Lopac-A-0152
Lopac0_000032
MLS000069400
Mi-W-3
MolPort-000-146-022
N07XX07
NCGC00015009-01
NCGC00015009-03
NCGC00015009-12
NCGC00024890-01
NCGC00024890-02
NCGC00024890-03
NCGC00024890-04
NCGC00024890-05
NCGC00024890-06
NCGC00024890-07
NCGC00024890-08
NCGC00024890-09
NCGC00024890-10
NINDS_000572
NSC 15041
NSC15041
Neurelan
Neurelan (TN)
P-Aminopyridine
PYRIDINE,4-AMINO
Philips 1861
Phillips 1861
Pimadin (free base)
Prc 1237
Pymadin
Pymadine
RCRA waste no. P008
SDCCGMLS-0066228.P001
SMR000058211
SPBio_001486
SPECTRUM1501130
STK298717
Spectrum2_001413
Spectrum3_000914
Spectrum4_001013
Spectrum5_001501
Spectrum_000155
Sustained Release, 4-Aminopyridine
TL8003344
Tocris-0940
UNII-BH3B64OKL9
UPCMLD-DP125
UPCMLD-DP125:001
VMI 10-3
VMI 103
VMI-10-3
VMI-103
VMI103
WLN: T6NJ DZ
[J.Pharmacol.Exp.Ther. 275:864 (1995)]
gamma-Aminopyridine
nchem.892-comp4
p-Aminopyridine
p-Aminopyridine [UN2671] [Poison]
p-Aminopyridine [UN2671] [Poison]
pyridin-4-amine
pyridin-4-ylamine
2Potassium Channel BlockersPhase 2151

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple SclerosisRecruitingNCT02391961Phase 2

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

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Anatomical Context for Internuclear Ophthalmoplegia

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MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

33
Eye, Thyroid, Liver, Prostate, Kidney, B cells, Lung

Animal Models for Internuclear Ophthalmoplegia or affiliated genes

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MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4AQP4, HEXA, LGI1, MBP, NF1, PSEN1
2MP:00028738.2GBA, IFNB1, MBP, NF1, OMG, PSEN1
3MP:00053867.3AQP4, CD55, GBA, HCRT, HEXA, LGI1
4MP:00053977.1AQP4, CD55, CXCR5, GBA, IFNB1, MBP
5MP:00036317.0AQP4, GBA, HCRT, HEXA, IFNB1, LGI1
6MP:00053766.8AQP4, GBA, HCRT, HEXA, IFNB1, MBP

Publications for Internuclear Ophthalmoplegia

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Articles related to Internuclear Ophthalmoplegia:

(show top 50)    (show all 255)
idTitleAuthorsYear
1
Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction. (26995360)
2016
2
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. (26944331)
2016
3
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. (24870222)
2014
4
Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. (24770935)
2014
5
Bilateral internuclear ophthalmoplegia associated with pediatric brain tumor progression: a case series and review of the literature. (24048548)
2013
6
Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct. (23830476)
2013
7
Pediatric internuclear ophthalmoplegia. (23470988)
2013
8
Motion diplopia in an isolated unilateral internuclear ophthalmoplegia: a new neurological symptom? (22790327)
2013
9
Rapid reversal of wall-eyed bilateral internuclear ophthalmoplegia. (22410451)
2012
10
Unilateral internuclear ophthalmoplegia after minor head injury. (22461944)
2012
11
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
12
Patterns of dissociate torsional-vertical nystagmus in internuclear ophthalmoplegia. (21951004)
2011
13
Bilateral Internuclear Ophthalmoplegia in a Patient with Devic's Neuromyelitis Optica. (21113284)
2010
14
Progressive supranuclear palsy with wall-eyed bilateral internuclear ophthalmoplegia syndrome. (18541806)
2008
15
Abducens-oculomotor synkinesis associated with internuclear ophthalmoplegia and acquired abducens nerve palsy. (16915907)
2006
16
Internuclear ophthalmoplegia. (16606784)
2006
17
Prognosis of ischemic internuclear ophthalmoplegia. (12208716)
2002
18
Internuclear ophthalmoplegia as the first sign of neuroborreliosis. (12420716)
2002
19
Reversible bilateral internuclear ophthalmoplegia following head injury. (11167289)
2001
20
Abduction paresis with rostral pontine and/or mesencephalic lesions: Pseudoabducens palsy and its relation to the so-called posterior internuclear ophthalmoplegia of Lutz. (11570979)
2001
21
Internuclear ophthalmoplegia with skew deviation. Two cases with an isolated circumscribed lesion of the medial longitudinal fasciculus. (11096232)
2000
22
Partial unilateral third nerve palsy and bilateral internuclear ophthalmoplegia: an unusual presentation of multiple sclerosis. (11040928)
2000
23
Pontine lesion of the abducens fasciculus producing so-called posterior internuclear ophthalmoplegia. (9018039)
1997
24
Toxic internuclear ophthalmoplegia related to antiobesity treatment. (1477455)
1992
25
Abduction nystagmus in internuclear ophthalmoplegia. (1455982)
1992
26
Bilateral internuclear ophthalmoplegia after smoking "crack" cocaine. (1838554)
1991
27
Internuclear ophthalmoplegia in acquired immunodeficiency syndrome. (2802452)
1989
28
Internuclear ophthalmoplegia in tuberculous meningitis. (2781611)
1989
29
Unilateral internuclear ophthalmoplegia, migraine, and supratentorial arteriovenous malformation. (3618721)
1987
30
Bilateral internuclear ophthalmoplegia in systemic lupus erythematosus. (2956286)
1987
31
Iatrogenic internuclear ophthalmoplegia. (3746320)
1986
32
Bilateral internuclear ophthalmoplegia due to hydrocephalus: a case report. (4069338)
1985
33
Anterior internuclear ophthalmoplegia. (4055693)
1985
34
Paresis of lateral gaze alternating with so-called posterior internuclear ophthalmoplegia. A partial paramedian pontine reticular formation-abducens nucleus syndrome. (3998774)
1985
35
Internuclear ophthalmoplegia in tuberculous meningitis. A report of two cases. (6468455)
1984
36
Bilateral internuclear ophthalmoplegia reversed by naloxone. (6830474)
1983
37
Drug-induced internuclear ophthalmoplegia. (6831328)
1983
38
Internuclear ophthalmoplegia in patients with toxic coma frequency, prognostic value, diagnostic significance. (6655778)
1983
39
Internuclear ophthalmoplegia after head trauma. (7258960)
1981
40
Bilateral internuclear ophthalmoplegia after intrathecal chemotherapy and cranial irradiation. (6172039)
1981
41
Internuclear ophthalmoplegia: recovery and plasticity. (7440105)
1980
42
Internuclear ophthalmoplegia following head injury. (7359205)
1980
43
Internuclear ophthalmoplegia. I. Saccades and dissociated nystagmus. (666604)
1978
44
Experimental internuclear ophthalmoplegia. (403929)
1977
45
An electrooculographic study of internuclear ophthalmoplegia. (617577)
1977
46
Abducting nystagmus in the medial longitudinal fasciculus (MLF) syndrome (internuclear ophthalmoplegia (INO)). (4718627)
1973
47
Vestibular influences on internuclear ophthalmoplegia. (5100343)
1971
48
Unilateral internuclear ophthalmoplegia. Report of a case including pathology. (5937495)
1966
49
Lateral gaze and convergence in internuclear ophthalmoplegia: a note on examination. (5948645)
1966
50
Unilateral internuclear ophthalmoplegia; a report of seven clinical cases and the postmortem findings in one case. (14788115)
1950

Variations for Internuclear Ophthalmoplegia

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Expression for genes affiliated with Internuclear Ophthalmoplegia

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Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for genes affiliated with Internuclear Ophthalmoplegia

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Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7GBA, HEXA
29.7AQP4, MBP, OMG

GO Terms for genes affiliated with Internuclear Ophthalmoplegia

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Cellular components related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:00057919.5HCRT, PSEN1

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sphingolipid metabolic processGO:00066659.9GBA, HEXA
2T cell activation involved in immune responseGO:00022869.8IFNB1, PSEN1
3negative regulation of protein kinase activityGO:00064699.4NF1, PSEN1
4cerebral cortex developmentGO:00219879.3NF1, PSEN1
5skin morphogenesisGO:00435899.1GBA, PSEN1

Sources for Internuclear Ophthalmoplegia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet