MCID: INT042
MIFTS: 37

Internuclear Ophthalmoplegia malady

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

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Aliases & Descriptions for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:538
ICD1030 H51.2
SNOMED-CT62 49823009
ICD9CM32 378.86
MeSH39 D015835

Summaries for Internuclear Ophthalmoplegia

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Wikipedia:71 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

MalaCards based summary: Internuclear Ophthalmoplegia is related to head injury and childhood brainstem astrocytoma, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways are Other glycan degradation and Spinal Cord Injury. Affiliated tissues include eye, brain and pons, and related mouse phenotypes are growth/size/body region and vision/eye.

Related Diseases for Internuclear Ophthalmoplegia

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Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1head injury10.2
2childhood brainstem astrocytoma10.2AQP4, MBP
3exotropia10.2
4lupus erythematosus10.2
5active cochlear meniere's disease10.2HEXA, LGI1, MBP
6crest syndrome10.2AQP4, IFNB1, MBP
7alopecia-intellectual disability syndrome10.2MBP, MOG
8systemic lupus erythematosus10.2
9ataxia10.2
10myasthenia gravis10.1
11schwannoma of twelfth cranial nerve10.1AQP4, MBP, MOG
12pulmonary hemosiderosis10.1AQP4, MBP, MOG
13endobronchial lipoma10.1AQP4, IFNB1, MOG
14status epilepticus10.1AQP4, MBP, MOG
15central neurocytoma10.1AQP4, NF1
16lipomatosis, multiple symmetric10.1MBP, MOG
17cervical adenoid basal carcinoma10.1HCRT, MBP, MOG
18cervicitis10.1
19meningitis10.1
20cerebral arteritis10.1NF1, PSEN1
21acute serous otitis media10.1KANTR, MBP
22ampulla of vater adenosquamous carcinoma10.0KANTR, MBP
23persistent mullerian duct syndrome10.0IFNB1, MBP, MOG, OMG
24neonatal jaundice10.0AQP4, IFNB1, MBP, MOG
25niemann-pick disease10.0AQP4, HCRT, MBP, MOG
26aneurysm10.0
27fungal meningitis10.0KANTR, NF1
28complex regional pain syndrome10.0AQP4, IFNB1, MBP, MOG
29advanced sleep phase syndrome, familial, 110.0AQP4, IFNB1, MBP, MOG
30urethritis9.9KANTR, MBP, PSEN1
31acrofrontofacionasal dysostosis9.9KANTR, MBP, PSEN1
32cerebellar ataxia9.9
33neuromyelitis optica9.9
34ptosis9.9
35strabismus9.9
36neuronitis9.9
37vasculitis9.9
38glioma9.9
39tuberculous meningitis9.9
40angina pectoris9.9KANTR, LGI1, PSEN1
41nerve fibre bundle defect9.9AQP4, KANTR, MBP, MOG
42schwannoma of jugular foramen9.9KANTR, MBP
43acquired metabolic disease9.9KANTR, PSEN1
44chiari malformation type ii9.8
45temporal arteritis9.8
46chronic inflammatory demyelinating polyneuropathy9.8
47hydrocephalus9.8
48african tick-bite fever9.8
49myelomeningocele9.8
50thrombosis9.8

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to internuclear ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

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UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1AQP4, GBA, HCRT, HEXA, LGI1, MBP
2MP:00053918.1AQP4, HEXA, LGI1, MBP, MOG, NF1
3MP:00053867.9AQP4, CD55, GBA, HCRT, HEXA, LGI1
4MP:00053977.8AQP4, CD55, CXCR5, GBA, IFNB1, MBP
5MP:00036317.7AQP4, GBA, HCRT, HEXA, IFNB1, LGI1

Drugs & Therapeutics for Internuclear Ophthalmoplegia

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Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
4-AminopyridineapprovedPhase 269504-24-51727
Synonyms:
.gamma.-Aminopyridine
275875_ALDRICH
36687_FLUKA
36687_RIEDEL
4 AP
4 Aminopyridine
4 Aminopyridine Sustained Release
4-AP
4-Aminopyridine
4-Aminopyridine 10
4-Aminopyridine Sustained Release
4-Pyridinamine
4-Pyridylamine
4-aminopyridine
5-22-09-00106 (Beilstein Handbook Reference)
504-24-5
A 0152
A0414
A78403_ALDRICH
AB1004971
AC-907/25014071
AC1L1C3R
AC1Q52BM
AI3-52547
AKOS000119896
Amaya
Amino-4 pyridine
Amino-4-Pyridine
Ampydin
Ampyra
Avitrol
Avitrol 200
BB_SC-6974
BRN 0105782
BSPBio_001562
Bio1_000353
Bio1_000842
Bio1_001331
Bio2_000282
Bio2_000762
C13728
C5H6N2
CHEBI:34385
CHEMBL284348
CID1727
Caswell No. 038
Compound 1861
D015761
D04127
Dalfampridine
DivK1c_000572
EINECS 207-987-9
EL-970
EPA Pesticide Chemical Code 069201
EU-0100032
FT-0083754
Fampridina
Fampridine
Fampridine (USAN/INN)
Fampridine SR
Fampridine [USAN:INN]
Fampridine-PR
Fampridine-SR
Fampridinum
HC150041
HMS1361O04
HMS1791O04
HMS1921H15
HMS1989O04
HMS2092F05
HMS501M14
HSDB 6037
IDI1_000572
IDI1_034032
InChI=1/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7
KBio1_000572
 
KBio2_000282
KBio2_000635
KBio2_002850
KBio2_003203
KBio2_005418
KBio2_005771
KBio3_000563
KBio3_000564
KBio3_001888
KBioGR_000282
KBioGR_001505
KBioSS_000282
KBioSS_000635
LS-130202
Lopac-A-0152
Lopac0_000032
MLS000069400
Mi-W-3
MolPort-000-146-022
N07XX07
NCGC00015009-01
NCGC00015009-03
NCGC00015009-12
NCGC00024890-01
NCGC00024890-02
NCGC00024890-03
NCGC00024890-04
NCGC00024890-05
NCGC00024890-06
NCGC00024890-07
NCGC00024890-08
NCGC00024890-09
NCGC00024890-10
NINDS_000572
NSC 15041
NSC15041
Neurelan
Neurelan (TN)
P-Aminopyridine
PYRIDINE,4-AMINO
Philips 1861
Phillips 1861
Pimadin (free base)
Prc 1237
Pymadin
Pymadine
RCRA waste no. P008
SDCCGMLS-0066228.P001
SMR000058211
SPBio_001486
SPECTRUM1501130
STK298717
Spectrum2_001413
Spectrum3_000914
Spectrum4_001013
Spectrum5_001501
Spectrum_000155
Sustained Release, 4-Aminopyridine
TL8003344
Tocris-0940
UNII-BH3B64OKL9
UPCMLD-DP125
UPCMLD-DP125:001
VMI 10-3
VMI 103
VMI-10-3
VMI-103
VMI103
WLN: T6NJ DZ
[J.Pharmacol.Exp.Ther. 275:864 (1995)]
gamma-Aminopyridine
nchem.892-comp4
p-Aminopyridine
p-Aminopyridine [UN2671] [Poison]
p-Aminopyridine [UN2671] [Poison]
pyridin-4-amine
pyridin-4-ylamine
2Potassium Channel BlockersPhase 2180

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple SclerosisRecruitingNCT02391961Phase 2

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

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Anatomical Context for Internuclear Ophthalmoplegia

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MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

36
Eye, Brain, Pons, Testes

Publications for Internuclear Ophthalmoplegia

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Articles related to Internuclear Ophthalmoplegia:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Bilateral Internuclear Ophthalmoplegia as a Presenting Manifestation of Primary SjAPgren's Syndrome. (27928415)
2016
2
Visualisation of the medial longitudinal fasciculus using fibre tractography in multiple sclerosis patients with internuclear ophthalmoplegia. (26787313)
2016
3
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. (26944331)
2016
4
Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction. (27567293)
2016
5
A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging. (27857923)
2016
6
Internuclear ophthalmoplegia. (27927777)
2016
7
Unilateral internuclear ophthalmoplegia, strabismus and transient torsional nystagmus in focal pontine infarction. (27448548)
2016
8
Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction. (26995360)
2016
9
Large basilar tip aneurysm causing anterior internuclear ophthalmoplegia. (25670869)
2015
10
Unilateral internuclear ophthalmoplegia with upbeat nystagmus from ischemic origin: evidence for the paramedian tract neurons as a vertical neural integrator? (26550407)
2015
11
Wall-eyed bilateral internuclear ophthalmoplegia. (26053827)
2015
12
Gaze palsy and exotropia in internuclear ophthalmoplegia. (25911021)
2015
13
Internuclear Ophthalmoplegia Associated with Anti-TNFI+ Medication. (25790247)
2015
14
Jerky seesaw nystagmus with internuclear ophthalmoplegia as the presenting finding in systemic lupus erythematosus. (25455550)
2014
15
Brainstem Infarction with Wall-eyed Bilateral Internuclear Ophthalmoplegia Syndrome and Vertical One-and-a-Half Syndrome. (24424330)
2014
16
Wall-eyed bilateral internuclear ophthalmoplegia: review of pathogenesis, diagnosis, prognosis and management. (25308307)
2014
17
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. (24870222)
2014
18
Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients. (24599322)
2014
19
Periprocedural stroke presenting as isolated unilateral internuclear ophthalmoplegia. (25114281)
2014
20
Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. (24770935)
2014
21
Unilateral Internuclear Ophthalmoplegia as an Isolated Presentation of Metastatic Melanoma. (25232840)
2014
22
Pediatric internuclear ophthalmoplegia. (23470988)
2013
23
An unusual aetiology for internuclear ophthalmoplegia. (23737577)
2013
24
Ocular vestibular evoked myogenic potentials to head tap and cervical vestibular evoked myogenic potentials to air-conducted sounds in isolated internuclear ophthalmoplegia. (24238926)
2013
25
Reversible cortical blindness and internuclear ophthalmoplegia after neurosurgical operation: case report and review of the literature. (23042139)
2013
26
Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct. (23830476)
2013
27
Bilateral internuclear ophthalmoplegia associated with pediatric brain tumor progression: a case series and review of the literature. (24048548)
2013
28
Images in clinical medicine. Bilateral internuclear ophthalmoplegia in multiple sclerosis. (23323922)
2013
29
Motion diplopia in an isolated unilateral internuclear ophthalmoplegia: a new neurological symptom? (22790327)
2013
30
Evolution of symmetric upbeat into dissociated torsional-upbeat nystagmus in internuclear ophthalmoplegia. (23664561)
2013
31
Unilateral internuclear ophthalmoplegia after minor head injury. (22461944)
2012
32
A small pontine infarct on DWI as a lesion responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome. (21655962)
2012
33
Ocular tilt reaction, internuclear ophthalmoplegia, and torsional nystagmus following mitral commissurotomy. (23084391)
2012
34
Complete bilateral horizontal internuclear ophthalmoplegia as a sign of multiple sclerosis relapse. (23040719)
2012
35
Bilateral internuclear ophthalmoplegia with unilateral horizontal gaze paresis. (22728510)
2012
36
Jerky see-saw nystagmus in internuclear ophthalmoplegia from a lower pontine lesion. (23166883)
2012
37
Teaching NeuroImages: Duret hemorrhage due to bilateral subdural hematomas causing internuclear ophthalmoplegia. (22987747)
2012
38
Neurocysticercosis presenting as isolated wall-eyed monocular internuclear ophthalmoplegia with contraversive ocular tilt reaction. (22346205)
2012
39
Rapid reversal of wall-eyed bilateral internuclear ophthalmoplegia. (22410451)
2012
40
Transposition surgery for internuclear ophthalmoplegia. (22881482)
2012
41
Pure upbeat nystagmus in association with bilateral internuclear ophthalmoplegia. (22445483)
2012
42
Patterns of dissociate torsional-vertical nystagmus in internuclear ophthalmoplegia. (21951004)
2011
43
Pure isolated internuclear ophthalmoplegia. (21841349)
2011
44
Ocular vestibular evoked myogenic potentials are abnormal in internuclear ophthalmoplegia. (21093360)
2011
45
Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody. (21300735)
2011
46
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
47
Top of the basilar" occlusion causing bilateral internuclear ophthalmoplegia. (21372475)
2011
48
Bilateral Internuclear Ophthalmoplegia in a Patient with Devic's Neuromyelitis Optica. (21113284)
2010
49
Wall-eyed bilateral internuclear ophthalmoplegia after ruptured aneurysm. (20457967)
2010
50
Ocular tilt reaction and internuclear ophthalmoplegia associated with venous sinus thrombosis: an unusual case. (19091852)
2010

Variations for Internuclear Ophthalmoplegia

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Expression for genes affiliated with Internuclear Ophthalmoplegia

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Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for genes affiliated with Internuclear Ophthalmoplegia

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Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8GBA, HEXA
29.7AQP4, MBP, OMG
38.9HCRT, MBP, NF1, PSEN1

GO Terms for genes affiliated with Internuclear Ophthalmoplegia

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Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:005077110.1OMG, PSEN1
2skin morphogenesisGO:00435899.9GBA, PSEN1
3T cell activation involved in immune responseGO:00022869.6IFNB1, PSEN1

Sources for Internuclear Ophthalmoplegia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet