IC
MCID: INT143
MIFTS: 57

Interstitial Cystitis (IC) malady

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Interstitial Cystitis

Aliases & Descriptions for Interstitial Cystitis:

Name: Interstitial Cystitis 12 50 56 41 3 14 69
Painful Bladder Syndrome 50 56 69
Bladder Pain Syndrome 56 69
Trigonitis 50 69
Ic 50 3
Chronic Interstitial Cystitis 69
Pelvic Congestion Syndrome 69
Cystitis, Interstitial 42
Pelvic Pain Syndrome 50
Ulcerative Cystitis 12
Hunner's Patch 50
Hunner's Ulcer 50
Pelvic Pain 41
Pbs 50

Characteristics:

Orphanet epidemiological data:

56
interstitial cystitis
Prevalence: 1-5/10000 (Finland),1-5/10000 (United States),1-9/1000000 (Finland); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:13949
MeSH 42 D018856
NCIt 47 C27189
SNOMED-CT 64 111409009 197834003
Orphanet 56 ORPHA37202
MESH via Orphanet 43 D018856
UMLS via Orphanet 70 C0282488
ICD10 via Orphanet 34 N30.1
ICD10 33 N30.1
UMLS 69 C0282488

Summaries for Interstitial Cystitis

MedlinePlus : 41 interstitial cystitis (ic) is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. it is far more common in women than in men. the symptoms vary from person to person. some people may have pain without urgency or frequency. others have urgency and frequency without pain. women's symptoms often get worse during their periods. they may also have pain with sexual intercourse. the cause of ic isn't known. there is no one test to tell if you have it. doctors often run tests to rule out other possible causes of symptoms. there is no cure for ic, but treatments can help most people feel better. they include distending, or inflating, the bladder bathing the inside of the bladder with a drug solution oral medicines electrical nerve stimulation physical therapy lifestyle changes bladder training in rare cases, surgery nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Interstitial Cystitis, also known as painful bladder syndrome, is related to splenic marginal zone lymphoma and trigonitis, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Interstitial Cystitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are CREB Pathway and Phospholipase-C Pathway. The drugs Acetylcholine and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and prostate, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 50 interstitial cystitis (ic) is a condition that causes discomfort or pain in the bladder and abdomen. symptoms may vary, but often include an urgent or frequent need to urinate. many of the individuals affected by ic are women. because ic varies so much in symptoms and severity, most researchers believe it is not one, but several diseases. in recent years, scientists have started to use the terms bladder pain syndrome (bps) or painful bladder syndrome (pbs) to describe cases with painful urinary symptoms that may not meet the strictest definition of ic. while there is no cure for ic/pbs, in many cases, the symptoms can be managed. treatments include dietary and lifestyle changes; distending, or inflating, the bladder; bathing the inside of the bladder with a medicine solution; oral medicines and in rare cases, surgery. last updated: 11/30/2011

CDC : 3 Interstitial Cystitis (IC) is a chronic bladder condition resulting in recurring discomfort or pain in the bladder or surrounding pelvic region. People with IC usually have inflamed or irritated bladder walls which can cause scarring and stiffening of the bladder. 

Wikipedia : 71 Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a type of chronic pain that... more...

Related Diseases for Interstitial Cystitis

Diseases in the Interstitial Cystitis family:

Chronic Interstitial Cystitis

Diseases related to Interstitial Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 splenic marginal zone lymphoma 29.3 BDNF CXCL8 IL6
2 trigonitis 12.4
3 chronic interstitial cystitis 12.3
4 congenital disorder of glycosylation, type ic 12.2
5 pseudohypoparathyroidism ic 12.1
6 bladder trigone cancer 12.0
7 cutis laxa, autosomal recessive, type ic 12.0
8 neuropathy, hereditary sensory and autonomic, type ic 11.9
9 lymphedema, hereditary, ic 11.9
10 amelogenesis imperfecta, type ic 11.9
11 glycogen storage disease ic 11.9
12 iridocorneal endothelial syndrome 11.8
13 isolated focal cortical dysplasia type ic 11.8
14 muscular dystrophy, limb-girdle, type ic 11.8
15 prune belly syndrome 11.7
16 alg6-congenital disorder of glycosylation 11.4
17 urethral syndrome 11.3
18 chronic pain 11.3
19 bladder disease 11.3
20 plastic bronchitis 11.1
21 myasthenic syndrome, congenital, 5 11.0
22 cogan-reese syndrome 10.9
23 usher syndrome, type 1c 10.9
24 charcot-marie-tooth disease, type 1c 10.9
25 cystitis 10.9
26 essential iris atrophy 10.9
27 convulsions, familial infantile, with paroxysmal choreoathetosis 10.9
28 autosomal dominant limb-girdle muscular dystrophy type 1c 10.9
29 joint disorders 10.7
30 bursitis 10.7
31 accessory navicular bone 10.7
32 diarrhea 10.7
33 persistent genital arousal disorder 10.7
34 congenital disorder of glycosylation, type ib 10.7
35 piriformis syndrome 10.7
36 corneal endothelial dystrophy 10.7
37 tendinitis 10.7
38 primary ciliary dyskinesia 10.7
39 oculomotor nerve paralysis 10.2 CXCL8 IL6
40 common peroneal nerve lesion 10.2 CXCL8 IL6
41 prostatitis 10.2
42 long bones of lower limb cancer 10.2 EGF IL6 NGF
43 acute necrotizing encephalitis 10.2 CDH1 HBEGF UMOD
44 malignant renovascular hypertension 10.2 NGF TAC1
45 neonatal hypoxic and ischemic brain injury 10.1 CXCL8 IL6
46 pseudoinflammatory fundus dystrophy 10.1 NGF TAC1
47 retinitis pigmentosa 51 10.1 ADRB2 CXCL8 IL6
48 thymic neuroendocrine carcinoma 10.1 CXCL8 IL6
49 neuropathy 10.1 CXCL8 EGF HBEGF IL6
50 urethritis 10.0

Comorbidity relations with Interstitial Cystitis via Phenotypic Disease Network (PDN):


Acute Cystitis Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Interstitial Cystitis:



Diseases related to Interstitial Cystitis

Symptoms & Phenotypes for Interstitial Cystitis

UMLS symptoms related to Interstitial Cystitis:


unspecified symptom associated with female genital organs, mittelschmerz, pain and other symptoms associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Interstitial Cystitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ADRB2 BDNF HBEGF IL6 NGF P2RX3
2 growth/size/body region MP:0005378 9.9 ADRB2 BDNF CDH1 CKAP4 EGF HBEGF
3 cardiovascular system MP:0005385 9.86 ADRB2 CDH1 HBEGF IL6 NGF P2RX3
4 homeostasis/metabolism MP:0005376 9.65 BDNF CDH1 HBEGF IL6 NGF P2RX3
5 integument MP:0010771 9.32 BDNF CDH1 CKAP4 EGF HBEGF IL6

Drugs & Therapeutics for Interstitial Cystitis

Drugs for Interstitial Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 480)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-84-3 187
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757 53477783
3
Desogestrel Approved Phase 4,Phase 3,Phase 2 54024-22-5 40973
4
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
5
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 797-63-7, 17489-40-6 13109
6
Benzocaine Approved Phase 4,Phase 3,Early Phase 1 1994-09-7, 94-09-7 2337
7
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Early Phase 1 15687-27-1 3672
8
Ketorolac Approved Phase 4,Phase 3 74103-06-3, 66635-83-4 3826
9
Drospirenone Approved Phase 4,Phase 3,Phase 2 67392-87-4 68873
10
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
11
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 2180-92-9, 38396-39-3 2474
12
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
13
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
14
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
15
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 137-58-6 3676
16
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-56-6 439302 53477758
17
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 3911 657181
18
Epinephrine Approved, Vet_approved Phase 4,Phase 1 51-43-4 5816
19
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
20
Menthol Approved Phase 4,Phase 2,Phase 1 2216-51-5 16666
21
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
22
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
23
Cycloserine Approved Phase 4 68-41-7 401 6234
24
Ethanol Approved Phase 4,Phase 2 64-17-5 702
25
Nicotine Approved Phase 4 54-11-5 942 89594
26
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2 71-58-9
27
Tibolone Approved Phase 4 5630-53-5
28
Gestodene Approved Phase 4,Phase 1,Phase 2 60282-87-3 3033968
29
Anastrozole Approved, Investigational Phase 4,Phase 2 120511-73-1 2187
30 Dienogest Approved Phase 4,Phase 3,Phase 2 65928-58-7
31
Nandrolone Approved, Experimental, Illicit Phase 4,Phase 3,Phase 2 434-22-0, 62-90-8 9904 229455
32
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3,Phase 2 360-70-3 9677
33
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
34
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
35
Gabapentin Approved, Investigational Phase 4,Phase 2,Phase 3 60142-96-3 3446
36
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
37
Ondansetron Approved Phase 4 99614-02-5 4595
38
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
39
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
40
Mefenamic acid Approved Phase 4,Phase 2 61-68-7 4044
41
Etoricoxib Approved, Investigational Phase 4,Phase 3 202409-33-4 123619
42
Piroxicam Approved, Investigational Phase 4 36322-90-4 5280452 54676228
43
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
44
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
45
Mannitol Approved, Investigational Phase 4,Phase 2 69-65-8 453 6251
46
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
47
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
48
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
49
Copper Approved Phase 4,Phase 3 15158-11-9, 7440-50-8 27099
50
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260

Interventional clinical trials:

(show top 50) (show all 860)
id Name Status NCT ID Phase
1 Efficacy Study of Pentosan Polysulfate Sodium,Hydrodistension and Combination Therapy for Bladder Pain Syndrome Unknown status NCT01895153 Phase 4
2 Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome Unknown status NCT01157507 Phase 4
3 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4
4 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Unknown status NCT02480647 Phase 4
5 A Pilot Study Comparing the Analgesic Efficacy of IV Ibuprofen and IV Ketorolac Unknown status NCT01514175 Phase 4
6 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4
7 Investigation of Sacroiliac Fusion Treatment (INSITE) Unknown status NCT01681004 Phase 4
8 Trigger Point Injections and Pelvic Rehabilitation for the Treatment of Pelvic Floor Myalgia and Sexual Pain Unknown status NCT02022722 Phase 4
9 IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea Unknown status NCT02373514 Phase 4
10 Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis Unknown status NCT02031523 Phase 4
11 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4
12 Study of Local Anesthesia as a Method to Decrease IUD Insertion Related Pain Unknown status NCT01967017 Phase 4
13 Is There Any Relation Between Pain and Stone Location in Retrograde Intrarenal Surgery? Unknown status NCT02430883 Phase 4
14 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4
15 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4
16 Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain Completed NCT02000401 Phase 4
17 Botox as a Treatment for Interstitial Cystitis in Women Completed NCT00194610 Phase 4
18 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4
19 Homeopathic Treatment of Chronic Pelvic Pain in Women With Endometriosis Completed NCT02427386 Phase 4
20 Effect of Nicotine on Chronic Pelvic Pain Completed NCT00440505 Phase 4
21 Paraspinous Anesthetic Block for Non-Responsive Pelvic Pain Completed NCT01635205 Phase 4
22 Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients Completed NCT02534688 Phase 4
23 Decapeptyl SR With Livial Add Back Therapy in the Management of Chronic Cyclical Pelvic Pain in Pre Menopausal Women Completed NCT00735852 Phase 4
24 Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain Completed NCT01056042 Phase 4
25 Tenaculum Pain Control Study Completed NCT01421641 Phase 4
26 Resveratrol for Pain Due to Endometriosis Completed NCT02475564 Phase 4
27 Anastrazole Plus GnRH-agonist in the Treatment of Endometriosis Recurrence Completed NCT01769781 Phase 4
28 Treatment Choice in Primary Dysmenorrhea Completed NCT03124524 Phase 4
29 Decreasing Narcotics in Advanced Pelvic Surgery Completed NCT02110719 Phase 4
30 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4
31 Postoperative Pain in Children With Cerebral Palsy After Pelvic and Femoral Osteotomies Completed NCT00964639 Phase 4
32 The Efficacy of Ayurved Siriraj Prasaplai for Treatment Primary Dysmenorrhea Completed NCT01598012 Phase 4
33 Quality of Life With Arcoxia in Women With Dysmenorrhea (0663-094) Completed NCT00380627 Phase 4
34 A Double Blind, Double Dummy, Randomized, Comparative Study Of The Efficacy And Safety Of Valdecoxib 40 Mg Twice Daily, As Needed In The First Menstrual Cycle Day And Then Once A Day, And Piroxicam 40 Mg Once A Day In The Treatment Of Patients With Primar Completed NCT00649415 Phase 4
35 A Comparison of Analgesic İmpacts of Piroxicam and Diclofenac Sodium in the Treatment of Primary Dysmenorrhea Completed NCT02253446 Phase 4
36 Surgical Pain Control With Ropivacaine by Atomized Delivery Completed NCT01480089 Phase 4
37 Effects of Dexmedetomidine During Radiofrequency Ablation of Abdominal Tumours Completed NCT02016391 Phase 4
38 Local Anaesthetic Infusion For Laparoscopic Hysterectomy Completed NCT01291147 Phase 4
39 Therapeutic Effects Analysis of Pudendal Nerve Infiltrations After 3 Months, in Patients Suffering of Pudendal Neuralgia Completed NCT00851513 Phase 4
40 Dilators for Dyspareunia Prevention Completed NCT01299363 Phase 4
41 Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair Completed NCT00153231 Phase 4
42 Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study Completed NCT00769054 Phase 4
43 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
44 Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache Completed NCT02760862 Phase 4
45 Intravesicular Onabotulinumtoxin A in Interstitial Cystitis Recruiting NCT02297100 Phase 4
46 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Recruiting NCT01312259 Phase 4
47 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4
48 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Recruiting NCT01793584 Phase 4
49 IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair Recruiting NCT02155738 Phase 4
50 Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia Recruiting NCT01935063 Phase 4

Search NIH Clinical Center for Interstitial Cystitis

Cochrane evidence based reviews: cystitis, interstitial

Genetic Tests for Interstitial Cystitis

Anatomical Context for Interstitial Cystitis

MalaCards organs/tissues related to Interstitial Cystitis:

39
Testes, Kidney, Prostate, Endothelial, Heart, B Cells, Pituitary

Publications for Interstitial Cystitis

Articles related to Interstitial Cystitis:

(show top 50) (show all 398)
id Title Authors Year
1
Transurethral Resection Alone Vs Resection Combined With Therapeutic Hydrodistention as Treatment for Ulcerative Interstitial Cystitis: Initial Experience With Propensity Score Matching Studies. ( 27720770 )
2017
2
Fulranumab in patients with interstitial cystitis/bladder pain syndrome: observations from a randomized, double-blind, placebo-controlled study. ( 28056917 )
2017
3
Re: Heparin and Alkalinized Lidocaine versus Alkalinized Lidocaine for Treatment of Interstitial Cystitis Symptoms. ( 27979536 )
2017
4
Revisiting the Role of Potassium Sensitivity Testing and Cystoscopic Hydrodistention for the Diagnosis of Interstitial Cystitis. ( 26999787 )
2016
5
Clinical phenotyping does not differentiate Hunner's lesion subtype of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS): A relook at the role of cystoscopy. ( 27117441 )
2016
6
A Phase II Study of Efficacy and Safety of a Novel, Oral SHIP1 Activator, AQX-1125, in Subjects with Moderate to Severe Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). ( 26968644 )
2016
7
Sensory hyperinnervation distinguishes bladder pain syndrome/interstitial cystitis from overactive bladder syndrome. ( 27378135 )
2016
8
Differences in Urodynamic Parameters between Women with Interstitial Cystitis/Bladder Pain Syndrome and Severe Overactive Bladder. ( 27130264 )
2016
9
Intravesical treatment for interstitial cystitis/painful bladder syndrome: a network meta-analysis. ( 27614759 )
2016
10
Hydrodistention of the bladder for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC). ( 27092957 )
2016
11
Study of the apoptotic effect of urine as a diagnostic biomarker in patients with interstitial cystitis. ( 27174573 )
2016
12
Efficacy and safety of botulinum toxin injection for interstitial cystitis/bladder pain syndrome: a systematic review and meta-analysis. ( 27139498 )
2016
13
Differential Expression of Renal Outer Medullary K(+) Channel and Voltage-gated K(+) Channel 7.1 in Bladder Urothelium of Patients With Interstitial Cystitis/Painful Bladder Syndrome. ( 27856205 )
2016
14
Urothelial Functional Protein and Sensory Receptors in Patients with Interstitial Cystitis/Bladder Pain Syndrome with and Without Hunner's Lesion. ( 27575016 )
2016
15
Elevated level of nerve growth factor in the bladder pain syndrome/interstitial cystitis: a meta-analysis. ( 27462520 )
2016
16
Interstitial cystitis: Another rotation of the kaleidoscope of autoimmunity? ( 27235121 )
2016
17
The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study. ( 27228524 )
2016
18
Long-term outcomes of intravesical dimethyl sulfoxide/heparin/hydrocortisone therapy for interstitial cystitis/bladder pain syndrome. ( 27987022 )
2016
19
CUA guideline: Diagnosis and treatment of interstitial cystitis/bladder pain syndrome. ( 27790294 )
2016
20
Stool-based biomarkers of interstitial cystitis/bladder pain syndrome. ( 27188581 )
2016
21
F16357, a novel PAR1 antagonist improves urodynamic parameters in a rat model of Interstitial Cystitis. ( 27111354 )
2016
22
Bladder Distension Increases Blood Flow in Pain-Related Brain Structures in Subjects With Interstitial Cystitis. ( 27018508 )
2016
23
Effects of hyperbaric oxygen therapy on hydrochloric acid-induced interstitial cystitis in rats: a histological and ultrastructural study. ( 27416685 )
2016
24
Adverse Events of Intravesical Onabotulinum Toxin A Injection between Patients with Overactive Bladder and Interstitial Cystitis-Different Mechanisms of Action of Botox on Bladder Dysfunction? ( 26999201 )
2016
25
Autonomic response during bladder hydrodistention reflects the severity of symptoms in patients with bladder pain syndrome/interstitial cystitis. ( 27028369 )
2016
26
Combined site-specific sacral neuromodulation and pudendal nerve release surgery in a patient with interstitial cystitis and persistent arousal. ( 27284095 )
2016
27
Urinary Metabolomics Identifies a Molecular Correlate of Interstitial Cystitis/Bladder Pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort. ( 27322470 )
2016
28
Increased toxic urinary cations in males with interstitial cystitis: a possible cause of bladder symptoms. ( 27027645 )
2016
29
Nursing Care of Women With Interstitial Cystitis/Painful Bladder Syndrome. ( 27067933 )
2016
30
Re: Classic Interstitial Cystitis: Unrelated to BPS. ( 27321512 )
2016
31
Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis. ( 27976711 )
2016
32
Re: Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation. ( 27302294 )
2016
33
Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis. ( 27376330 )
2016
34
Intravesical Botulinum Toxin A Injections for Bladder Pain Syndrome/Interstitial Cystitis: A Systematic Review and Meta-Analysis of Controlled Studies. ( 27624897 )
2016
35
Is Urethrectomy Necessary During Cystectomy in Patients With Interstitial Cystitis or Bladder Pain Syndrome? ( 27424120 )
2016
36
A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. ( 27654012 )
2016
37
Mindfulness-based stress reduction as a novel treatment for interstitial cystitis/bladder pain syndrome: a randomized controlled trial. ( 27116196 )
2016
38
Bladder dysfunction in 2016: New insights into interstitial cystitis and chronic pelvic pain syndromes. ( 27898100 )
2016
39
Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications and bladder hydrodistension: A case report. ( 27930554 )
2016
40
Update on the Pathology and Diagnosis of Interstitial Cystitis/Bladder Pain Syndrome: A Review. ( 27032552 )
2016
41
A prospective randomized controlled multicentre trial comparing intravesical DMSO and chondroA^tin sulphate 2% for painful bladder syndrome/interstitial cystitis. ( 27819752 )
2016
42
Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis. ( 27339056 )
2016
43
Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome. ( 27627755 )
2016
44
Therapeutic Potential of Human Chorionic Gonadotropin Against Painful Bladder Syndrome/Interstitial Cystitis. ( 27004802 )
2016
45
Important role of physicians in addressing psychological aspects of interstitial cystitis/bladder pain syndrome (IC/BPS): a qualitative analysis. ( 27581769 )
2016
46
Mast cell activation syndrome in pain syndromes bladder pain syndrome/interstitial cystitis and vulvodynia. ( 27297031 )
2016
47
Interstitial Cystitis/Bladder Pain Syndrome: A Urologic Mystery. ( 27032550 )
2016
48
SU-G-IeP1-10: Permeability Evaluation of Interstitial Cystitis by DCE-MRI of the Bladder. ( 28048092 )
2016
49
A cohort study of interstitial cystitis/bladder pain syndrome and hysterectomy. ( 26942595 )
2016
50
Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease. ( 27915472 )
2016

Variations for Interstitial Cystitis

Expression for Interstitial Cystitis

Search GEO for disease gene expression data for Interstitial Cystitis.

Pathways for Interstitial Cystitis

GO Terms for Interstitial Cystitis

Cellular components related to Interstitial Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 BDNF CDH1 CXCL8 EGF HBEGF IL6
2 receptor complex GO:0043235 9.13 ADRB2 EGF P2RX3

Biological processes related to Interstitial Cystitis according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.84 IL6 KNG1 NGF TRPV1
2 cell-cell signaling GO:0007267 9.8 ADRB2 BDNF NGF TAC1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.74 KNG1 TAC1 TRPV1
4 cellular response to tumor necrosis factor GO:0071356 9.72 CXCL8 IL6 TRPV1
5 phosphatidylinositol-mediated signaling GO:0048015 9.7 EGF HBEGF NGF
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 EGF HBEGF IL6
7 response to pain GO:0048265 9.56 TAC1 TRPV1
8 negative regulation of ERBB signaling pathway GO:1901185 9.51 EGF HBEGF
9 activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 9.48 ADRB2 EGF
10 behavioral response to pain GO:0048266 9.46 P2RX3 TRPV1
11 response to heat GO:0009408 9.43 IL6 P2RX3 TRPV1
12 positive regulation of acute inflammatory response GO:0002675 9.4 IL6 TAC1
13 regulation of protein localization to cell surface GO:2000008 9.37 BDNF EGF
14 inflammatory response GO:0006954 9.35 CXCL8 IL6 KNG1 TAC1 TRPV1
15 diet induced thermogenesis GO:0002024 9.32 ADRB2 TRPV1
16 urinary bladder smooth muscle contraction GO:0014832 9.16 P2RX3 TRPV1
17 response to cold GO:0009409 8.8 ADRB2 IL6 P2RX3

Molecular functions related to Interstitial Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.02 BDNF EGF HBEGF IL6 NGF

Sources for Interstitial Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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