Interstitial Cystitis

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Interstitial Cystitis

MalaCards integrated aliases for Interstitial Cystitis:

Name: Interstitial Cystitis 12 50 56 41 3 14 69
Painful Bladder Syndrome 50 56 69
Bladder Pain Syndrome 56 69
Trigonitis 50 69
Ic 50 3
Interstitial Cystitis/painful Bladder Syndrome 56
Interstitial Cystitis/bladder Pain Syndrome 56
Chronic Interstitial Cystitis 69
Pelvic Congestion Syndrome 69
Cystitis, Interstitial 42
Pelvic Pain Syndrome 50
Ulcerative Cystitis 12
Hunner's Patch 50
Hunner's Ulcer 50
Pelvic Pain 41
Ic/bps 56
Ic/pbs 56
Pbs 50


Orphanet epidemiological data:

interstitial cystitis
Prevalence: 1-5/10000 (Finland),1-5/10000 (United States),1-9/1000000 (Finland); Age of onset: All ages; Age of death: normal life expectancy;


External Ids:

Disease Ontology 12 DOID:13949
MeSH 42 D018856
NCIt 47 C27189
SNOMED-CT 64 111409009 197834003
Orphanet 56 ORPHA37202
MESH via Orphanet 43 D018856
UMLS via Orphanet 70 C0282488 C0600040 C3160917 more
ICD10 via Orphanet 34 N30.1
ICD10 33 N30.1
UMLS 69 C0282488

Summaries for Interstitial Cystitis

MedlinePlus : 41 interstitial cystitis (ic) is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. it is far more common in women than in men. the symptoms vary from person to person. some people may have pain without urgency or frequency. others have urgency and frequency without pain. women's symptoms often get worse during their periods. they may also have pain with sexual intercourse. the cause of ic isn't known. there is no one test to tell if you have it. doctors often run tests to rule out other possible causes of symptoms. there is no cure for ic, but treatments can help most people feel better. they include distending, or inflating, the bladder bathing the inside of the bladder with a drug solution oral medicines electrical nerve stimulation physical therapy lifestyle changes bladder training in rare cases, surgery nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Interstitial Cystitis, also known as painful bladder syndrome, is related to trigonitis and chronic interstitial cystitis, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Interstitial Cystitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are CREB Pathway and Phospholipase-C Pathway. The drugs Acetylcholine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and prostate, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 50 interstitial cystitis (ic) is a condition that causes discomfort or pain in the bladder and abdomen. symptoms may vary, but often include an urgent or frequent need to urinate. many of the individuals affected by ic are women. because ic varies so much in symptoms and severity, most researchers believe it is not one, but several diseases. in recent years, scientists have started to use the terms bladder pain syndrome (bps) or painful bladder syndrome (pbs) to describe cases with painful urinary symptoms that may not meet the strictest definition of ic. while there is no cure for ic/pbs, in many cases, the symptoms can be managed. treatments include dietary and lifestyle changes; distending, or inflating, the bladder; bathing the inside of the bladder with a medicine solution; oral medicines and in rare cases, surgery. last updated: 11/30/2011

CDC : 3 Interstitial Cystitis (IC) is a chronic bladder condition resulting in recurring discomfort or pain in the bladder or surrounding pelvic region. People with IC usually have inflamed or irritated bladder walls which can cause scarring and stiffening of the bladder. 

Wikipedia : 72 Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a type of chronic pain that... more...

Related Diseases for Interstitial Cystitis

Diseases in the Interstitial Cystitis family:

Chronic Interstitial Cystitis

Diseases related to Interstitial Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
id Related Disease Score Top Affiliating Genes
1 trigonitis 12.4
2 chronic interstitial cystitis 12.3
3 congenital disorder of glycosylation, type ic 12.2
4 bladder trigone cancer 12.0
5 pseudohypoparathyroidism ic 12.0
6 cutis laxa, autosomal recessive, type ic 12.0
7 neuropathy, hereditary sensory and autonomic, type ic 11.9
8 amelogenesis imperfecta, type ic 11.9
9 lymphedema, hereditary, ic 11.8
10 glycogen storage disease ic 11.8
11 muscular dystrophy, limb-girdle, type ic 11.8
12 iridocorneal endothelial syndrome 11.8
13 isolated focal cortical dysplasia type ic 11.8
14 prune belly syndrome 11.7
15 alg6-congenital disorder of glycosylation 11.4
16 urethral syndrome 11.3
17 chronic pain 11.3
18 bladder disease 11.3
19 plastic bronchitis 11.1
20 myasthenic syndrome, congenital, 5 11.0
21 charcot-marie-tooth disease, type 1c 10.9
22 cogan-reese syndrome 10.9
23 cystitis 10.9
24 essential iris atrophy 10.9
25 usher syndrome, type 1c 10.9
26 convulsions, familial infantile, with paroxysmal choreoathetosis 10.9
27 joint disorders 10.7
28 primary ciliary dyskinesia 10.7
29 bursitis 10.7
30 accessory navicular bone 10.7
31 diarrhea 10.7
32 persistent genital arousal disorder 10.7
33 congenital disorder of glycosylation, type ib 10.7
34 piriformis syndrome 10.7
35 tendinitis 10.7
36 chandler syndrome 10.7
37 oculomotor nerve paralysis 10.6 CXCL8 IL6
38 common peroneal nerve lesion 10.6 CXCL8 IL6
39 drug rash with eosinophilia and systemic symptoms 10.6 CXCL8 IL6
40 spirillary rat-bite fever 10.5 CXCL8 IL6
41 thymus lymphoma 10.5 EGF IL6 NGF
42 hypermobility of coccyx 10.5 NGF TRPV1
43 malignant renovascular hypertension 10.5 NGF TAC1
44 schwannoma of ureter 10.5 CXCL8 IL6
45 psychotic disorder 10.4 CXCL8 IL6
46 marasmus 10.4 NGF TRPV1
47 pseudoainhum 10.4 NGF TAC1
48 choroiditis 10.4 CXCL8 IL6 UMOD
49 infancy electroclinical syndrome 10.4 CXCL8 IL6
50 x-linked intellectual disability, porteous type 10.3 CKAP4 EGF

Comorbidity relations with Interstitial Cystitis via Phenotypic Disease Network (PDN):

Acute Cystitis Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Interstitial Cystitis:

Diseases related to Interstitial Cystitis

Symptoms & Phenotypes for Interstitial Cystitis

UMLS symptoms related to Interstitial Cystitis:

unspecified symptom associated with female genital organs, mittelschmerz, pain and other symptoms associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Interstitial Cystitis:

id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 BDNF HBEGF IL6 NGF P2RX3 TAC1
2 growth/size/body region MP:0005378 9.9 ADRB2 BDNF CDH1 CKAP4 EGF HBEGF
3 cardiovascular system MP:0005385 9.86 ADRB2 CDH1 HBEGF IL6 NGF P2RX3
4 homeostasis/metabolism MP:0005376 9.65 ADRB2 BDNF CDH1 HBEGF IL6 NGF
5 integument MP:0010771 9.32 BDNF CDH1 CKAP4 EGF HBEGF IL6

Drugs & Therapeutics for Interstitial Cystitis

Drugs for Interstitial Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Acetaminophen Approved Phase 4 103-90-2 1983
Cycloserine Approved Phase 4 68-41-7 401 6234
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
11 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
14 abobotulinumtoxinA Phase 4,Phase 2,Phase 1
15 Botulinum Toxins Phase 4,Phase 2,Phase 1
16 Botulinum Toxins, Type A Phase 4,Phase 2,Phase 1
17 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Neuromuscular Agents Phase 4,Phase 2,Phase 1
19 onabotulinumtoxinA Phase 4,Phase 2,Phase 1
20 Anti-Arrhythmia Agents Phase 4,Phase 2
21 Adrenergic Agents Phase 4,Phase 3
22 Adrenergic Agonists Phase 4,Phase 3
23 Adrenergic alpha-2 Receptor Agonists Phase 4
24 Adrenergic alpha-Agonists Phase 4
25 Analgesics Phase 4,Phase 3,Phase 2
26 Analgesics, Non-Narcotic Phase 4,Phase 3
27 Anti-Anxiety Agents Phase 4
28 Hypnotics and Sedatives Phase 4
29 Oxytocics Phase 4
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4
32 Antirheumatic Agents Phase 4,Phase 3,Phase 2
33 Cyclooxygenase Inhibitors Phase 4
34 Ketorolac Tromethamine Phase 4
35 Anti-Bacterial Agents Phase 4,Phase 3
36 Antibiotics, Antitubercular Phase 4,Phase 3
37 Anti-Infective Agents Phase 4,Phase 2
38 Antimetabolites Phase 4
39 Antitubercular Agents Phase 4
40 Renal Agents Phase 4
41 Analgesics, Opioid Phase 4,Phase 2
42 Narcotics Phase 4,Phase 2
43 Anticoagulants Phase 4,Phase 2
44 Calcium, Dietary Phase 4,Phase 2
45 Psychotropic Drugs Phase 4,Phase 3
46 Tranquilizing Agents Phase 4,Phase 3
47 Adrenergic Antagonists Phase 4
48 Adrenergic beta-1 Receptor Antagonists Phase 4
49 Adrenergic beta-Antagonists Phase 4
50 Antihypertensive Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 139)

id Name Status NCT ID Phase Drugs
1 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
2 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
3 Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
4 Botox as a Treatment for Interstitial Cystitis in Women Completed NCT00194610 Phase 4 Botox
5 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
6 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Oral Tablet;Placebo Oral Tablet
7 Intravesicular Onabotulinumtoxin A in Interstitial Cystitis Recruiting NCT02297100 Phase 4 Onabotulinumtoxin A
8 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Recruiting NCT01312259 Phase 4
9 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
10 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository Enrolling by invitation NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
11 Effectiveness and Safety Study of Pentosan Polysulfate Sodium for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
12 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
13 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
14 Acupuncture for the Treatment of Interstitial Cystitis (IC) Symptoms Unknown status NCT00094874 Phase 3
15 Efficacy Study of Adalimumab to Treat Interstitial Cystitis Completed NCT01295814 Phase 3 Adalimumab
16 Omalizumab in Interstitial Cystitis/Bladder Pain Syndrome Completed NCT01294878 Phase 3 omalizumab
17 URACYST® For the Treatment of GAG Deficient Interstitial Cystitis Completed NCT00150488 Phase 2, Phase 3
18 Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS) Completed NCT00124306 Phase 3 Amitriptyline
19 A Pilot Study of the Effects of Mirabegron on Symptoms in Patients With Interstitial Cystitis Recruiting NCT02787083 Phase 3 Mirabegron;Placebo
20 Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome Recruiting NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
21 A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression Recruiting NCT02497287 Phase 3 Esketamine (Intranasal Spray);Duloxetine (Oral Antidepressant);Escitalopram (Oral Antidepressant);Sertraline (Oral Antidepressant);Venlafaxine Extended Release (XR) (Oral Antidepressant)
22 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Active, not recruiting NCT02497976 Phase 3 Placebo
23 A Randomized Multicenter Double-Blind CT to Evaluate the Efficacy and Safety of Mycophenolate Mofetil . . . Terminated NCT00451867 Phase 3 Mycophenolate Mofetil;Mycofenolate Mofetil (MMF);Placebo
24 Efficacy of Botulinum Toxin Type A in Patients With Bladder Pain Syndrome/Intersticial Cystitis and Hunners' Lesions Unknown status NCT01437579 Phase 2
25 Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action Completed NCT01990898 Phase 2 Cyclosporine
26 Interstitial Cystitis Completed NCT00056251 Phase 2
27 Prospective Trial Comparing Response to Hyperbaric Oxygen Treatment in Patients With Interstitial Cystitis Completed NCT01479725 Phase 2
28 Efficacy and Safety Study of Uracyst to Treat Interstitial Cystitis/Painful Bladder Syndrome Completed NCT00919113 Phase 2 2% sodium chondroitin sulfate;Placebo
29 An Effectiveness And Safety Study Of PD 0299685 For The Treatment Of Symptoms Associated With Interstitial Cystitis Completed NCT00739739 Phase 2 PD 0299685 at 15mg BID;PD 0299685 at 30mg BID;placebo for PD 0299685
30 Phase II Study Efficacy and Safety of Two Dosing Regimens of MN-001 in Patients With Interstitial Cystitis Completed NCT00295854 Phase 2 MN-001 BID;MN-001;Placebo
31 Intravesical Botulinum Toxin A Injections in Treatment of Interstitial Cystitis Refractory to Conventional Treatment Completed NCT01969773 Phase 2 Botulinum toxin A;Normal saline instillation
32 A Pilot Clinical Investigation of the Efficacy and Safety of Uracyst® Versus Placebo in Patients With Interstitial Cystitis/Painful Bladder Syndrome. Completed NCT00527917 Phase 2
33 Intravesical Instillation of Liposome Encapsulated Botulinum Toxin A (Lipotoxin) in Treatment of Interstitial Cystitis Completed NCT02247557 Phase 2 Liposome encapsulated BoNT-A;BOTOX 200U in normal saline;Normal saline
34 Study of Biomarkers and the Relaxation Response Using Guided Imagery in Women With IC Completed NCT00420550 Phase 2
35 A Randomized Study Comparing Placebo and ASP3652 in the Treatment of Women With Bladder Pain Syndrome / Interstitial Cystitis (BPS/IC) Completed NCT01613586 Phase 2 ASP3652;Placebo
36 An Effectiveness and Safety Study of PF-04383119 for the Treatment of Pain in Interstitial Cystitis Completed NCT00601484 Phase 2 PF-04383119;Placebo
37 Efficacy and Safety of AQX-1125 in IC/BPS Completed NCT01882543 Phase 2 AQX-1125;Placebo
38 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
39 A Safety and Efficacy Study of LiRIS® in Females With Interstitial Cystitis/Bladder Pain Syndrome Completed NCT02411110 Phase 2
40 Efficacy and Safety of Intravesical Instillations of Botulinum Toxin in TC-3 Gel in IC Patients Completed NCT01997983 Phase 1, Phase 2
41 The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Subjects With Interstitial Cystitis /Bladder Pain Syndrome Completed NCT01569438 Phase 2 Gefapixant;Sugar Pill
42 Study of URG101 in Painful Bladder Syndrome and Interstitial Cystitis Completed NCT00517868 Phase 2 URG101;Placebo
43 OXN PR vs Placebo in Opioid-naive Subjects Suffering From Severe Pain Due to Bladder Pain Syndrome (BPS) Completed NCT01197261 Phase 2 Oxycodone naloxone prolonged release tablets;Placebo tablets
44 Study of U101 for Bladder Pain and/or Urgency Completed NCT00256542 Phase 2 Alkalinized Lidocaine-Heparin
45 A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression Completed NCT01998958 Phase 2 Esketamine 14 mg;Esketamine 28 mg;Esketamine 56 mg;Esketamine 84 mg;Placebo
46 A Study to Investigate Efficacy, Safety, Pharmacodynamics and Pharmacokinetics of ASP6294 in the Treatment of Female Subjects With Bladder Pain Syndrome/Interstitial Cystitis Recruiting NCT03282318 Phase 2 ASP6294;Placebo
47 Evaluation of Intravesical LP08 in Patients With Interstitial Cystitis/Painful Bladder Syndrome Recruiting NCT01393223 Phase 2 LP-08 80mg;Normal Saline Placebo;LP-08 20mg
48 Engage 24: Evaluation of the Safety and Effectiveness of URG101 in Subjects With Interstitial Cystitis/Bladder Pain Syndrome Recruiting NCT02591199 Phase 2 URG101;Placebo;Lidocaine;Heparin
49 Comparative Study Suburothelial and Trigonal Botulinum Toxin A Injection in Treatment of Interstitial Cystitis Recruiting NCT03076762 Phase 2 intravesical onabotulinumtoxinA injection
50 Bladder Directed vs. Pelvic Floor Therapy in IC/BPS Recruiting NCT02870738 Phase 2 Bladder Instillations

Search NIH Clinical Center for Interstitial Cystitis

Cochrane evidence based reviews: cystitis, interstitial

Genetic Tests for Interstitial Cystitis

Anatomical Context for Interstitial Cystitis

MalaCards organs/tissues related to Interstitial Cystitis:

Testes, Kidney, Prostate, Brain, Skin, Endothelial, Pituitary

Publications for Interstitial Cystitis

Articles related to Interstitial Cystitis:

(show top 50) (show all 419)
id Title Authors Year
Naftopidil Improves Symptoms in a Rat Model of Tranilast-Induced Interstitial Cystitis. ( 28394500 )
Evaluation of the incidence and risk factors associated with persistent frequency in interstitial cystitis/bladder pain syndrome and the efficacy of antimuscarinic treatment. ( 28868507 )
Sacral Neuromodulation for Refractory Bladder Pain Syndrome/Interstitial Cystitis: a Global Systematic Review and Meta-analysis. ( 28887515 )
Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain. ( 28595240 )
Sensory mapping of pelvic dermatomes in women with interstitial cystitis/bladder pain syndrome. ( 28628232 )
Childhood bladder and bowel dysfunction predicts irritable bowel syndrome phenotype in adult interstitial cystitis/bladder pain syndrome patients. ( 28798827 )
Somatoform disorder as a predictor of interstitial cystitis/bladder pain syndrome: Evidence from a nested case-control study and a retrospective cohort study. ( 28471951 )
Clinical Efficacy of 1-Year Intensive Systematic Dietary Manipulation as Complementary and Alternative Medicine Therapies on Female Patients With Interstitial Cystitis/Bladder Pain Syndrome. ( 28435032 )
An Immunogenic Peptide, T2 Induces Interstitial Cystitis/Painful Bladder Syndrome: an Autoimmune Mouse Model for Interstitial Cystitis/Painful Bladder Syndrome. ( 28799018 )
Inhibition of microRNA-214 promotes epithelial-mesenchymal transition process and induces interstitial cystitis in postmenopausal women by upregulating Mfn2. ( 28729638 )
Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. ( 28482861 )
Re: Heparin and Alkalinized Lidocaine versus Alkalinized Lidocaine for Treatment of Interstitial Cystitis Symptoms. ( 27979536 )
Efficacy, Side Effects, and Monitoring of Oral Cyclosporine in Interstitial Cystitis-Bladder Pain Syndrome. ( 28528859 )
Clinical comparison of intravesical hyaluronic acid and chondroitin sulfate therapies in the treatment of bladder pain syndrome/interstitial cystitis. ( 28480984 )
Kenalog Injection into Hunner's Lesions as a Treatment for Interstitial Cystitis/Bladder Pain Syndrome. ( 28878600 )
Significant Linkage Evidence for Interstitial Cystitis/Painful Bladder Syndrome on Chromosome 3. ( 28734863 )
Fulranumab in patients with interstitial cystitis/bladder pain syndrome: observations from a randomized, double-blind, placebo-controlled study. ( 28056917 )
A new player in interstitial cystitis/bladder pain syndrome: platelet-activating factor - PAF and its connection to smoking. ( 28408637 )
Somatic symptoms are sensitive in predicting interstitial cystitis/bladder pain syndrome. ( 28486876 )
Transurethral Resection Alone Vs Resection Combined With Therapeutic Hydrodistention as Treatment for Ulcerative Interstitial Cystitis: Initial Experience With Propensity Score Matching Studies. ( 27720770 )
Alexithymia and anesthetic bladder capacity in interstitial cystitis/bladder pain syndrome. ( 28789788 )
Interstitial cystitis intravesical therapy. ( 28791236 )
Expression profile of urothelial transcription factors in bladder biopsies with interstitial cystitis. ( 28626955 )
Urothelial Functional Protein and Sensory Receptors in Patients with Interstitial Cystitis/Bladder Pain Syndrome with and Without Hunner's Lesion. ( 27575016 )
A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. ( 27654012 )
Intravesical Botulinum Toxin A Injections for Bladder Pain Syndrome/Interstitial Cystitis: A Systematic Review and Meta-Analysis of Controlled Studies. ( 27624897 )
Therapeutic Potential of Human Chorionic Gonadotropin Against Painful Bladder Syndrome/Interstitial Cystitis. ( 27004802 )
F16357, a novel PAR1 antagonist improves urodynamic parameters in a rat model of Interstitial Cystitis. ( 27111354 )
Pathomechanism of Interstitial Cystitis/Bladder Pain Syndrome and Mapping the Heterogeneity of Disease. ( 27915472 )
Efficacy and safety of botulinum toxin injection for interstitial cystitis/bladder pain syndrome: a systematic review and meta-analysis. ( 27139498 )
Study of the apoptotic effect of urine as a diagnostic biomarker in patients with interstitial cystitis. ( 27174573 )
Interstitial Cystitis/Bladder Pain Syndrome: A Urologic Mystery. ( 27032550 )
Hydrodistention of the bladder for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC). ( 27092957 )
Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015. ( 27218442 )
Long-term outcomes of intravesical dimethyl sulfoxide/heparin/hydrocortisone therapy for interstitial cystitis/bladder pain syndrome. ( 27987022 )
Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome. ( 27627755 )
Differences in Urodynamic Parameters between Women with Interstitial Cystitis/Bladder Pain Syndrome and Severe Overactive Bladder. ( 27130264 )
Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis. ( 27339056 )
Elevated level of nerve growth factor in the bladder pain syndrome/interstitial cystitis: a meta-analysis. ( 27462520 )
SU-G-IeP1-10: Permeability Evaluation of Interstitial Cystitis by DCE-MRI of the Bladder. ( 28048092 )
Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis. ( 27376330 )
Urinary Metabolomics Identifies a Molecular Correlate of Interstitial Cystitis/Bladder Pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort. ( 27322470 )
Mast cell activation syndrome in pain syndromes bladder pain syndrome/interstitial cystitis and vulvodynia. ( 27297031 )
Bladder dysfunction in 2016: New insights into interstitial cystitis and chronic pelvic pain syndromes. ( 27898100 )
Re: Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation. ( 27302294 )
CUA guideline: Diagnosis and treatment of interstitial cystitis/bladder pain syndrome. ( 27790294 )
Combined site-specific sacral neuromodulation and pudendal nerve release surgery in a patient with interstitial cystitis and persistent arousal. ( 27284095 )
Update on the Pathology and Diagnosis of Interstitial Cystitis/Bladder Pain Syndrome: A Review. ( 27032552 )
A prospective randomized controlled multicentre trial comparing intravesical DMSO and chondroA^tin sulphate 2% for painful bladder syndrome/interstitial cystitis. ( 27819752 )
Autonomic response during bladder hydrodistention reflects the severity of symptoms in patients with bladder pain syndrome/interstitial cystitis. ( 27028369 )

Variations for Interstitial Cystitis

Expression for Interstitial Cystitis

Search GEO for disease gene expression data for Interstitial Cystitis.

Pathways for Interstitial Cystitis

GO Terms for Interstitial Cystitis

Cellular components related to Interstitial Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 BDNF CDH1 CXCL8 EGF HBEGF IL6
2 receptor complex GO:0043235 9.13 ADRB2 EGF P2RX3

Biological processes related to Interstitial Cystitis according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.85 IL6 KNG1 NGF TRPV1
2 cell-cell signaling GO:0007267 9.81 ADRB2 BDNF NGF TAC1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.74 KNG1 TAC1 TRPV1
4 cellular response to tumor necrosis factor GO:0071356 9.71 CXCL8 IL6 TRPV1
5 phosphatidylinositol-mediated signaling GO:0048015 9.7 EGF HBEGF NGF
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 EGF HBEGF IL6
7 response to pain GO:0048265 9.56 TAC1 TRPV1
8 negative regulation of ERBB signaling pathway GO:1901185 9.49 EGF HBEGF
9 activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 9.48 ADRB2 EGF
10 positive regulation of acute inflammatory response GO:0002675 9.46 IL6 TAC1
11 behavioral response to pain GO:0048266 9.43 P2RX3 TRPV1
12 regulation of protein localization to cell surface GO:2000008 9.37 BDNF EGF
13 inflammatory response GO:0006954 9.35 CXCL8 IL6 KNG1 TAC1 TRPV1
14 response to heat GO:0009408 9.33 IL6 P2RX3 TRPV1
15 diet induced thermogenesis GO:0002024 9.32 ADRB2 TRPV1
16 urinary bladder smooth muscle contraction GO:0014832 9.26 P2RX3 TRPV1
17 response to cold GO:0009409 8.8 ADRB2 IL6 P2RX3

Molecular functions related to Interstitial Cystitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.02 BDNF EGF HBEGF IL6 NGF

Sources for Interstitial Cystitis

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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