MCID: INT065
MIFTS: 27

Interstitial Keratitis malady

Categories: Eye diseases

Aliases & Classifications for Interstitial Keratitis

Aliases & Descriptions for Interstitial Keratitis:

Name: Interstitial Keratitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9857
ICD10 33 H16.30
ICD9CM 35 370.50
SNOMED-CT 64 1763009 193784002
UMLS 69 C0155088

Summaries for Interstitial Keratitis

MalaCards based summary : Interstitial Keratitis is related to diffuse interstitial keratitis and idiopathic linear interstitial keratitis. An important gene associated with Interstitial Keratitis is DCN (Decorin), and among its related pathways/superpathways are ECM-receptor interaction and ECM proteoglycans. Affiliated tissues include eye, t cells and testes, and related phenotypes are Increased gamma-H2AX phosphorylation and immune system

Wikipedia : 71 Interstitial keratitis (IK) is corneal scarring due to chronic inflammation of the corneal stroma.... more...

Related Diseases for Interstitial Keratitis

Diseases related to Interstitial Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 diffuse interstitial keratitis 12.1
2 idiopathic linear interstitial keratitis 11.9
3 cogan syndrome 11.0
4 late congenital syphilis 11.0
5 keratitis 10.7
6 syphilis 10.1
7 amelogenesis imperfecta 1j 10.0 CD36 DCN
8 germ cell and embryonal cancer 10.0 CD36 DCN
9 onychocytic matricoma 10.0 CD36 DCN
10 congenital syphilis 9.9
11 immunodeficiency 30 9.9 COL9A1 DCN
12 uveitis 9.8
13 hidradenitis suppurativa 9.8
14 hidradenitis 9.8
15 periostitis 9.7
16 aortitis 9.7
17 median arcuate ligament syndrome 9.6 FBXO7 PTPRJ UTP6
18 onchocerciasis 9.6
19 chorioretinitis 9.6
20 lyme disease 9.6
21 leishmaniasis 9.6
22 posterior uveitis 9.6
23 amyloidosis 9.6
24 mucocutaneous leishmaniasis 9.6
25 ophthalmia neonatorum 9.6
26 rheumatoid arthritis 9.6
27 hypothyroidism 9.6
28 malaria 9.6
29 gapo syndrome 9.6
30 mastocytosis 9.6
31 cervicitis 9.6
32 spasticity 9.6
33 arthritis 9.6
34 vaccinia 9.6
35 cataract 9.6
36 sensorineural hearing loss 9.6
37 thyroiditis 9.6
38 herpes simplex 9.6
39 chlamydia 9.6
40 vasculitis 9.6
41 choroiditis 9.6
42 smallpox 9.6
43 alternating esotropia 9.1 CD36 COL9A1 DCN FBXO7 PTPRJ UTP6

Graphical network of the top 20 diseases related to Interstitial Keratitis:



Diseases related to Interstitial Keratitis

Symptoms & Phenotypes for Interstitial Keratitis

GenomeRNAi Phenotypes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 8.92 COL9A1 DCN PTPRJ UTP6

MGI Mouse Phenotypes related to Interstitial Keratitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 CD36 COL9A1 DCN FBXO7 PTPRJ

Drugs & Therapeutics for Interstitial Keratitis

Search Clinical Trials , NIH Clinical Center for Interstitial Keratitis

Genetic Tests for Interstitial Keratitis

Anatomical Context for Interstitial Keratitis

MalaCards organs/tissues related to Interstitial Keratitis:

39
Eye, T Cells, Testes, Bone, Bone Marrow, Thyroid

Publications for Interstitial Keratitis

Articles related to Interstitial Keratitis:

(show top 50) (show all 144)
id Title Authors Year
1
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. ( 27227396 )
2016
2
Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. ( 26960587 )
2016
3
Descemet's scroll in syphilitic interstitial keratitis: a case report with anterior segment evaluation and a literature review. ( 26451126 )
2015
4
Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. ( 24715922 )
2014
5
Bilateral Interstitial Keratitis and Granulomatous Uveitis of Tubercular Origin. ( 23538732 )
2013
6
Linear interstitial keratitis: a distinct clinical entity revisited. ( 22406946 )
2012
7
Interstitial keratitis and sensorineural hearing loss as a manifestation of rheumatoid arthritis: clinical lessons from a rare complication. ( 23242087 )
2012
8
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. ( 22146546 )
2012
9
Exacerbation of zoster interstitial keratitis after zoster vaccination in an adult. ( 20697015 )
2010
10
GAPO syndrome: a case associated with bilateral interstitial keratitis and hypothyroidism. ( 20032780 )
2010
11
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. ( 20628295 )
2010
12
Interstitial keratitis following varicella vaccination. ( 19204247 )
2009
13
Effective treatment with topical cyclosporine of a child with steroid-dependent interstitial keratitis. ( 18850565 )
2008
14
Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. ( 17963106 )
2007
15
Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis. ( 16633043 )
2006
16
Syphilitic interstitial keratitis: treatment with immunosuppressive drug combination therapy. ( 15220743 )
2004
17
Immune recovery disease: a case of interstitial keratitis and tonic pupil following bone marrow transplantation. ( 15548824 )
2004
18
Results of penetrating keratoplasty in syphilitic interstitial keratitis. ( 14750229 )
2003
19
Rapid improvement of chronic interstitial keratitis with acitretin. ( 12446388 )
2002
20
Images in clinical medicine. Interstitial keratitis as the initial expression of syphilitic reactivation. ( 12050340 )
2002
21
A description of human T-lymphotropic virus type I-related chronic interstitial keratitis in 20 patients. ( 11239861 )
2001
22
Interstitial keratitis and deafness in a patient with cutaneous sarcoidosis. ( 11702638 )
2001
23
Gold induced interstitial keratitis. ( 11702733 )
2001
24
Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis. ( 11188990 )
2001
25
Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans. ( 11069987 )
2000
26
Lyme disease associated with unilateral interstitial keratitis. ( 9894947 )
1999
27
Interstitial keratitis in a five-year-old. ( 10093958 )
1999
28
Interstitial keratitis. ( 10081734 )
1998
29
Etiology of immune stromal (interstitial) keratitis. ( 9603383 )
1998
30
In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. ( 9030983 )
1996
31
Syphilitic interstitial keratitis with bilateral funnel-shaped iridocorneal adhesions. A case report. ( 8744842 )
1996
32
Interstitial keratitis as presenting ophthalmic sign of sarcoidosis in a child. ( 7636703 )
1995
33
Characterization of native pathogenic antigens of Onchocerca volvulus: identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model. ( 7789415 )
1995
34
Diagnosis of congenital syphilis in adults presenting with interstitial keratitis. ( 8069759 )
1994
35
Unilateral iridoschisis associated with syphilitic interstitial keratitis and glaucoma. ( 8297067 )
1993
36
Case report: clinical and radiological features of Cogan's syndrome--non-syphilitic interstitial keratitis, audiovestibular symptoms and systemic manifestations. ( 1606804 )
1992
37
Secondary localized amyloidosis in interstitial keratitis. Clinicopathologic findings. ( 1594229 )
1992
38
Interstitial keratitis and iridoschisis in congenital syphilis. ( 1401161 )
1992
39
Syphilitic interstitial keratitis masquerading as staphylococcal marginal keratitis. ( 2929714 )
1989
40
Syphilitic interstitial keratitis. ( 2810630 )
1989
41
Iridoschisis associated with syphilitic interstitial keratitis. ( 2912127 )
1989
42
Late corneal opacities in the syndrome of interstitial keratitis and vestibulo-auditory symptoms. ( 2554651 )
1989
43
Experimental interstitial keratitis induced by Onchocerca volvulus antigens. ( 2460073 )
1988
44
Interstitial keratitis in untreated latent (late) syphilis. ( 3801205 )
1986
45
Cogan's syndrome: acute vestibular and auditory dysfunction with interstitial keratitis. ( 6333187 )
1984
46
Scrolls of Descemet's membrane in healed syphilitic interstitial keratitis. ( 6677851 )
1983
47
The retrocorneal ridge in syphilitic and herpetic interstitial keratitis: an electron-microscopic study. ( 7046592 )
1982
48
Collagenase levels in a new model of experimental herpetic interstitial keratitis. ( 6246865 )
1980
49
Treatment of experimental herpetic interstitial keratitis with medroxyprogesterone. ( 6244808 )
1980
50
Interstitial keratitis caused by American (mucocutaneous) leishmaniasis. ( 434070 )
1979

Variations for Interstitial Keratitis

Expression for Interstitial Keratitis

Search GEO for disease gene expression data for Interstitial Keratitis.

Pathways for Interstitial Keratitis

Pathways related to Interstitial Keratitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 CD36 COL9A1
2 10.38 COL9A1 DCN

GO Terms for Interstitial Keratitis

Cellular components related to Interstitial Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 8.96 CD36 COL9A1
2 specific granule membrane GO:0035579 8.62 CD36 PTPRJ

Biological processes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 8.62 COL9A1 DCN

Sources for Interstitial Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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