MCID: INT065
MIFTS: 29

Interstitial Keratitis

Categories: Eye diseases

Aliases & Classifications for Interstitial Keratitis

MalaCards integrated aliases for Interstitial Keratitis:

Name: Interstitial Keratitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9857
ICD10 32 H16.30
ICD9CM 34 370.50
SNOMED-CT 64 1763009 193784002
UMLS 69 C0155088

Summaries for Interstitial Keratitis

MalaCards based summary : Interstitial Keratitis is related to diffuse interstitial keratitis and idiopathic linear interstitial keratitis. An important gene associated with Interstitial Keratitis is DCN (Decorin), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. Affiliated tissues include eye, t cells and testes.

Wikipedia : 72 Interstitial keratitis (IK) is corneal scarring due to chronic inflammation of the corneal stroma.... more...

Related Diseases for Interstitial Keratitis

Graphical network of the top 20 diseases related to Interstitial Keratitis:



Diseases related to Interstitial Keratitis

Symptoms & Phenotypes for Interstitial Keratitis

Drugs & Therapeutics for Interstitial Keratitis

Search Clinical Trials , NIH Clinical Center for Interstitial Keratitis

Genetic Tests for Interstitial Keratitis

Anatomical Context for Interstitial Keratitis

MalaCards organs/tissues related to Interstitial Keratitis:

38
Eye, T Cells, Testes, Bone, Bone Marrow, Thyroid

Publications for Interstitial Keratitis

Articles related to Interstitial Keratitis:

(show top 50) (show all 147)
# Title Authors Year
1
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. ( 29256984 )
2018
2
Syphilitic Interstitial Keratitis in a Patient Diagnosed With SjAPgren's Syndrome. ( 29280828 )
2017
3
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. ( 28687682 )
2017
4
Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. ( 26960587 )
2016
5
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. ( 27227396 )
2016
6
Descemet's scroll in syphilitic interstitial keratitis: a case report with anterior segment evaluation and a literature review. ( 26451126 )
2015
7
Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. ( 24715922 )
2014
8
Bilateral Interstitial Keratitis and Granulomatous Uveitis of Tubercular Origin. ( 23538732 )
2013
9
Interstitial keratitis and sensorineural hearing loss as a manifestation of rheumatoid arthritis: clinical lessons from a rare complication. ( 23242087 )
2012
10
Linear interstitial keratitis: a distinct clinical entity revisited. ( 22406946 )
2012
11
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. ( 22146546 )
2012
12
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. ( 20628295 )
2010
13
GAPO syndrome: a case associated with bilateral interstitial keratitis and hypothyroidism. ( 20032780 )
2010
14
Exacerbation of zoster interstitial keratitis after zoster vaccination in an adult. ( 20697015 )
2010
15
Interstitial keratitis following varicella vaccination. ( 19204247 )
2009
16
Effective treatment with topical cyclosporine of a child with steroid-dependent interstitial keratitis. ( 18850565 )
2008
17
Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. ( 17963106 )
2007
18
Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis. ( 16633043 )
2006
19
Syphilitic interstitial keratitis: treatment with immunosuppressive drug combination therapy. ( 15220743 )
2004
20
Immune recovery disease: a case of interstitial keratitis and tonic pupil following bone marrow transplantation. ( 15548824 )
2004
21
Results of penetrating keratoplasty in syphilitic interstitial keratitis. ( 14750229 )
2003
22
Images in clinical medicine. Interstitial keratitis as the initial expression of syphilitic reactivation. ( 12050340 )
2002
23
Rapid improvement of chronic interstitial keratitis with acitretin. ( 12446388 )
2002
24
Interstitial keratitis and deafness in a patient with cutaneous sarcoidosis. ( 11702638 )
2001
25
Gold induced interstitial keratitis. ( 11702733 )
2001
26
A description of human T-lymphotropic virus type I-related chronic interstitial keratitis in 20 patients. ( 11239861 )
2001
27
Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis. ( 11188990 )
2001
28
Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans. ( 11069987 )
2000
29
Interstitial keratitis in a five-year-old. ( 10093958 )
1999
30
Lyme disease associated with unilateral interstitial keratitis. ( 9894947 )
1999
31
Interstitial keratitis. ( 10081734 )
1998
32
Etiology of immune stromal (interstitial) keratitis. ( 9603383 )
1998
33
In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. ( 9030983 )
1996
34
Syphilitic interstitial keratitis with bilateral funnel-shaped iridocorneal adhesions. A case report. ( 8744842 )
1996
35
Characterization of native pathogenic antigens of Onchocerca volvulus: identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model. ( 7789415 )
1995
36
Interstitial keratitis as presenting ophthalmic sign of sarcoidosis in a child. ( 7636703 )
1995
37
Diagnosis of congenital syphilis in adults presenting with interstitial keratitis. ( 8069759 )
1994
38
Unilateral iridoschisis associated with syphilitic interstitial keratitis and glaucoma. ( 8297067 )
1993
39
Interstitial keratitis and iridoschisis in congenital syphilis. ( 1401161 )
1992
40
Secondary localized amyloidosis in interstitial keratitis. Clinicopathologic findings. ( 1594229 )
1992
41
Case report: clinical and radiological features of Cogan's syndrome--non-syphilitic interstitial keratitis, audiovestibular symptoms and systemic manifestations. ( 1606804 )
1992
42
Iridoschisis associated with syphilitic interstitial keratitis. ( 2912127 )
1989
43
Syphilitic interstitial keratitis masquerading as staphylococcal marginal keratitis. ( 2929714 )
1989
44
Syphilitic interstitial keratitis. ( 2810630 )
1989
45
Late corneal opacities in the syndrome of interstitial keratitis and vestibulo-auditory symptoms. ( 2554651 )
1989
46
Experimental interstitial keratitis induced by Onchocerca volvulus antigens. ( 2460073 )
1988
47
Interstitial keratitis in untreated latent (late) syphilis. ( 3801205 )
1986
48
Cogan's syndrome: acute vestibular and auditory dysfunction with interstitial keratitis. ( 6333187 )
1984
49
Scrolls of Descemet's membrane in healed syphilitic interstitial keratitis. ( 6677851 )
1983
50
The retrocorneal ridge in syphilitic and herpetic interstitial keratitis: an electron-microscopic study. ( 7046592 )
1982

Variations for Interstitial Keratitis

Expression for Interstitial Keratitis

Search GEO for disease gene expression data for Interstitial Keratitis.

Pathways for Interstitial Keratitis

Pathways related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 COL9A1 DCN TNC
2
Show member pathways
11.31 CD36 COL9A1 TNC
3 10.56 COL9A1 DCN TNC

GO Terms for Interstitial Keratitis

Cellular components related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 9.16 CD36 COL9A1
2 specific granule membrane GO:0035579 8.96 CD36 PTPRJ
3 proteinaceous extracellular matrix GO:0005578 8.8 COL9A1 DCN TNC

Biological processes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.26 COL9A1 DCN
2 wound healing GO:0042060 9.16 DCN TNC
3 response to mechanical stimulus GO:0009612 8.96 DCN TNC
4 extracellular matrix organization GO:0030198 8.8 COL9A1 DCN TNC

Sources for Interstitial Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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