MCID: INT065
MIFTS: 27

Interstitial Keratitis malady

Category: Eye diseases

Aliases & Classifications for Interstitial Keratitis

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Aliases & Descriptions for Interstitial Keratitis:

Name: Interstitial Keratitis 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:9857
ICD1030 H16.30
SNOMED-CT62 1763009, 193784002
ICD9CM32 370.50

Summaries for Interstitial Keratitis

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Wikipedia:71 Interstitial keratitis (IK) is corneal scarring due to chronic inflammation of the corneal stroma.... more...

MalaCards based summary: Interstitial Keratitis is related to diffuse interstitial keratitis and idiopathic linear interstitial keratitis. An important gene associated with Interstitial Keratitis is DCN (Decorin), and among its related pathways are ECM proteoglycans and ECM-receptor interaction. Affiliated tissues include eye, t cells and testes, and related mouse phenotypes are Increased gamma-H2AX phosphorylation and immune system.

Related Diseases for Interstitial Keratitis

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Graphical network of the top 20 diseases related to Interstitial Keratitis:



Diseases related to interstitial keratitis

Symptoms & Phenotypes for Interstitial Keratitis

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GenomeRNAi Phenotypes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00053-A8.1COL9A1, DCN, PTPRJ, UTP6

MGI Mouse Phenotypes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5CD36, COL9A1, DCN, FBXO7, PTPRJ

Drugs & Therapeutics for Interstitial Keratitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Interstitial Keratitis

Genetic Tests for Interstitial Keratitis

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Anatomical Context for Interstitial Keratitis

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MalaCards organs/tissues related to Interstitial Keratitis:

36
Eye, T cells, Testes, Bone, Bone marrow, Thyroid

Publications for Interstitial Keratitis

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Articles related to Interstitial Keratitis:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. (27227396)
2016
2
Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. (26960587)
2016
3
Descemet's scroll in syphilitic interstitial keratitis: a case report with anterior segment evaluation and a literature review. (26451126)
2015
4
Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. (24715922)
2014
5
Bilateral Interstitial Keratitis and Granulomatous Uveitis of Tubercular Origin. (23538732)
2013
6
Linear interstitial keratitis: a distinct clinical entity revisited. (22406946)
2012
7
Interstitial keratitis and sensorineural hearing loss as a manifestation of rheumatoid arthritis: clinical lessons from a rare complication. (23242087)
2012
8
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. (22146546)
2012
9
Exacerbation of zoster interstitial keratitis after zoster vaccination in an adult. (20697015)
2010
10
GAPO syndrome: a case associated with bilateral interstitial keratitis and hypothyroidism. (20032780)
2010
11
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. (20628295)
2010
12
Interstitial keratitis following varicella vaccination. (19204247)
2009
13
Effective treatment with topical cyclosporine of a child with steroid-dependent interstitial keratitis. (18850565)
2008
14
Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. (17963106)
2007
15
Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis. (16633043)
2006
16
Syphilitic interstitial keratitis: treatment with immunosuppressive drug combination therapy. (15220743)
2004
17
Immune recovery disease: a case of interstitial keratitis and tonic pupil following bone marrow transplantation. (15548824)
2004
18
Results of penetrating keratoplasty in syphilitic interstitial keratitis. (14750229)
2003
19
Rapid improvement of chronic interstitial keratitis with acitretin. (12446388)
2002
20
Images in clinical medicine. Interstitial keratitis as the initial expression of syphilitic reactivation. (12050340)
2002
21
A description of human T-lymphotropic virus type I-related chronic interstitial keratitis in 20 patients. (11239861)
2001
22
Interstitial keratitis and deafness in a patient with cutaneous sarcoidosis. (11702638)
2001
23
Gold induced interstitial keratitis. (11702733)
2001
24
Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis. (11188990)
2001
25
Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans. (11069987)
2000
26
Lyme disease associated with unilateral interstitial keratitis. (9894947)
1999
27
Interstitial keratitis in a five-year-old. (10093958)
1999
28
Interstitial keratitis. (10081734)
1998
29
Etiology of immune stromal (interstitial) keratitis. (9603383)
1998
30
In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. (9030983)
1996
31
Syphilitic interstitial keratitis with bilateral funnel-shaped iridocorneal adhesions. A case report. (8744842)
1996
32
Interstitial keratitis as presenting ophthalmic sign of sarcoidosis in a child. (7636703)
1995
33
Characterization of native pathogenic antigens of Onchocerca volvulus: identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model. (7789415)
1995
34
Diagnosis of congenital syphilis in adults presenting with interstitial keratitis. (8069759)
1994
35
Unilateral iridoschisis associated with syphilitic interstitial keratitis and glaucoma. (8297067)
1993
36
Case report: clinical and radiological features of Cogan's syndrome--non-syphilitic interstitial keratitis, audiovestibular symptoms and systemic manifestations. (1606804)
1992
37
Secondary localized amyloidosis in interstitial keratitis. Clinicopathologic findings. (1594229)
1992
38
Interstitial keratitis and iridoschisis in congenital syphilis. (1401161)
1992
39
Syphilitic interstitial keratitis masquerading as staphylococcal marginal keratitis. (2929714)
1989
40
Syphilitic interstitial keratitis. (2810630)
1989
41
Iridoschisis associated with syphilitic interstitial keratitis. (2912127)
1989
42
Late corneal opacities in the syndrome of interstitial keratitis and vestibulo-auditory symptoms. (2554651)
1989
43
Experimental interstitial keratitis induced by Onchocerca volvulus antigens. (2460073)
1988
44
Interstitial keratitis in untreated latent (late) syphilis. (3801205)
1986
45
Cogan's syndrome: acute vestibular and auditory dysfunction with interstitial keratitis. (6333187)
1984
46
Scrolls of Descemet's membrane in healed syphilitic interstitial keratitis. (6677851)
1983
47
The retrocorneal ridge in syphilitic and herpetic interstitial keratitis: an electron-microscopic study. (7046592)
1982
48
Collagenase levels in a new model of experimental herpetic interstitial keratitis. (6246865)
1980
49
Treatment of experimental herpetic interstitial keratitis with medroxyprogesterone. (6244808)
1980
50
Interstitial keratitis caused by American (mucocutaneous) leishmaniasis. (434070)
1979

Variations for Interstitial Keratitis

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Expression for genes affiliated with Interstitial Keratitis

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Search GEO for disease gene expression data for Interstitial Keratitis.

Pathways for genes affiliated with Interstitial Keratitis

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Pathways related to Interstitial Keratitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5COL9A1, DCN
2
Show member pathways
9.5CD36, COL9A1

GO Terms for genes affiliated with Interstitial Keratitis

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Cellular components related to Interstitial Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen trimerGO:000558110.0CD36, COL9A1
2specific granule membraneGO:00355799.2CD36, PTPRJ

Biological processes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1animal organ morphogenesisGO:00098879.5COL9A1, DCN

Sources for Interstitial Keratitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet