ILD
MCID: INT066
MIFTS: 53

Interstitial Lung Disease (ILD) malady

Respiratory diseases category
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Summaries for Interstitial Lung Disease

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MedlinePlus:33 Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. the inflammation and scarring make it hard to get enough oxygen. the scarring is called pulmonary fibrosis. breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. specific types include black lung disease among coal miners, from inhaling coal dust farmer's lung, from inhaling farm dust asbestosis, from inhaling asbestos fibers siderosis, from inhaling iron from mines or welding fumes silicosis, from inhaling silica dust other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. some types of interstitial lung disease have no known cause. treatment depends on the type of exposure and the stage of the disease. it may involve medicines, oxygen therapy, or a lung transplant in severe cases.

MalaCards based summary: Interstitial Lung Disease, also known as lung diseases, interstitial, is related to pulmonary hypertension and lung cancer. An important gene associated with Interstitial Lung Disease is SFTPC (surfactant protein C), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and ERK Signaling. The compounds infasurf and popg have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:65 Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD), refers to a... more...

Aliases & Classifications for Interstitial Lung Disease

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Interstitial Lung Disease, Aliases & Descriptions:

Name: Interstitial Lung Disease 8 10
Lung Diseases, Interstitial 62
Lung Diseases Interstitial 44
 
Interstitial Lung Diseases 33
Ild 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:3082
SNOMED-CT57 233703007, 64667001
MeSH34 D017563

Related Diseases for Interstitial Lung Disease

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Diseases related to Interstitial Lung Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary hypertension31.3SFTPC, SFTPB
2lung cancer31.0SFTPB, SFTPD, CCL22, ITGA3
3respiratory failure30.9SFTPD, SFTPB
4pulmonary fibrosis30.7CCL22, CCL17, SFTPC, SFTPD
5lung adenocarcinoma30.7SFTPC, SFTPD, SFTPB
6adenocarcinoma30.5SFTPB, SFTPD, SFTPC, ITGA3
7pneumonia30.4SFTPB, SFTPD, SFTPC, CCL17, CCL22, IL22
8non-small cell lung carcinoma30.3SFTPC, SFTPD, SFTPB
9idiopathic pulmonary fibrosis30.3SFTPB, SFTPD, SFTPC, CCL17, CCL22
10eosinophilic pneumonia30.2CCL22, CCL17
11sarcoidosis30.1CD27, CHIT1, SFTPD
12cystic fibrosis29.9SFTPB, SFTPD, SFTPC, CCL17, CCL22
13asthma29.1SFTPB, SFTPD, SFTPC, SCGB3A2, CHIT1, CCL17
14dermatomyositis11.0
15arthritis10.8
16rheumatoid arthritis10.8
17connective tissue disease10.8
18polymyositis10.8
19scleroderma10.8
20hypertension10.7
21amyopathic dermatomyositis10.7
22bronchiolitis10.7
23respiratory bronchiolitis-associated interstitial lung disease10.7
24antisynthetase syndrome10.6
25children's interstitial lung disease10.6
26myopathy10.6
27myositis10.5
28common variable immunodeficiency10.4
29desquamative interstitial pneumonia10.4
30usual interstitial pneumonia10.4
31respiratory bronchiolitis - interstitial lung disease10.4
32filariasis10.4CHIT1
33colorectal cancer10.3
34mixed connective tissue disease10.3
35esophagitis10.3
36melanoma10.3
37pneumothorax10.3
38pulmonary function10.3
39interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.3
40adenosquamous carcinoma10.3SFTPC, SFTPD
41nonspecific interstitial pneumonia10.3
42erdheim-chester disease10.3
43hermansky-pudlak syndrome10.3
44idiopathic interstitial pneumonia10.3
45lupus erythematosus10.3
46pancreatitis10.3
47surfactant dysfunction10.3
48cor pulmonale10.3
49pulmonary alveolar proteinosis10.2SFTPB, SFTPD, SFTPC
50large cell carcinoma10.2SFTPB, SFTPD, SFTPC

Graphical network of the top 20 diseases related to Interstitial Lung Disease:



Diseases related to interstitial lung disease

Symptoms for Interstitial Lung Disease

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Drugs & Therapeutics for Interstitial Lung Disease

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Drug clinical trials:

Search ClinicalTrials for Interstitial Lung Disease

Search NIH Clinical Center for Interstitial Lung Disease

Genetic Tests for Interstitial Lung Disease

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Anatomical Context for Interstitial Lung Disease

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MalaCards organs/tissues related to Interstitial Lung Disease:

32
Lung, Testes, Monocytes, Brain, Skin, T cells, B cells, Thyroid, Breast, Endothelial, Neutrophil, Bone, Lymph node, Heart, Smooth muscle

Animal Models for Interstitial Lung Disease or affiliated genes

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MGI Mouse Phenotypes related to Interstitial Lung Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9SFTPB, SFTPD, SFTPC, ITGA3, IL22
2MP:00053877.0SFTPD, SFTPC, CHIT1, CCL17, ITGA3, IL22

Publications for Interstitial Lung Disease

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Articles related to Interstitial Lung Disease:

(show top 50)    (show all 751)
idTitleAuthorsYear
1
Cardiorespiratory Function Before and After Aerobic Exercise Training in Patients With Interstitial Lung Disease. (25313451)
2014
2
"Interstitial Lung Disease in Undifferentiated Forms of Connective Tissue Disease" (25048539)
2014
3
Subclinical interstitial lung disease: Is it a risk factor for fatal radiation pneumonitis following stereotactic body radiotherapy? (24199683)
2014
4
Anti-PL7 antisynthetase syndrome: A rare cause of autoimmune-mediated interstitial lung disease. (25092352)
2014
5
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma. (23797722)
2013
6
Statins and the risk of interstitial lung disease: a cohort study. (23299962)
2013
7
Anti-CADM-140/MDA5 autoantibody titer correlates with disease activity and predicts disease outcome in patients with dermatomyositis and rapidly progressive interstitial lung disease. (22644102)
2013
8
Severe acute interstitial lung disease after crizotinib therapy in a patient with EML4-ALK-positive non-small-cell lung cancer. (23169500)
2013
9
Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease. (23716070)
2013
10
Riociguat for interstitial lung disease and pulmonary hypertension: a pilot trial. (22936711)
2013
11
Connective Tissue Disease-Associated Interstitial Lung Disease: A Focused Review. (24371251)
2013
12
Natural history of five children with surfactant protein C mutations and interstitial lung disease. (24347114)
2013
13
Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control study. (24038004)
2013
14
Mycophenolate mofetil therapy for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. (23615839)
2013
15
Comparison of characteristics of connective tissue disease-associated interstitial lung diseases, undifferentiated connective tissue disease-associated interstitial lung diseases, and idiopathic pulmonary fibrosis in Chinese Han population: a retrospective study. (24171031)
2013
16
MUC5B and interstitial lung disease. (24029742)
2013
17
Nilotinib-induced interstitial lung disease. (23877149)
2013
18
The clinical significance of HRCT in evaluation of patients with rheumatoid arthritis-associated interstitial lung disease: a report from China. (21132550)
2012
19
Obstructive sleep apnea does not promote esophageal reflux in fibrosing interstitial lung disease. (22521226)
2012
20
Rituximab therapy for refractory interstitial lung disease related to antisynthetase syndrome. (22280877)
2012
21
Interstitial lung disease in connective tissue disorders. (22901890)
2012
22
Subclinical interstitial lung disease: no place for crackles? (22855543)
2012
23
Bronchoalveolar lavage for the evaluation of interstitial lung disease: is it clinically useful? (21540304)
2011
24
Interstitial lung disease in a child heterozygous for the 1549C-->GAA (121ins2) mutation of surfactant protein B. (21965505)
2011
25
Idiopathic interstitial lung disease with anti-SSA antibody. (21984768)
2011
26
Enhanced expression of Fas Ligand (FasL) in the lower airways of patients with fibrotic interstitial lung diseases (ILDs). (22252758)
2011
27
Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease. (21791074)
2011
28
Interstitial lung disease induced or exacerbated by TNF-targeted therapies: analysis of 122 cases. (21277618)
2011
29
IV immunoglobulin might be considered as a first-line treatment of severe interstitial lung disease associated with polymyositis. (21813543)
2011
30
Effect of stem cell therapy on amiodarone induced fibrosing interstitial lung disease in albino rat. (24298346)
2011
31
Interstitial lung disease in children. (21572385)
2011
32
Pulmonary hypertension secondary to interstitial lung disease. (21510729)
2011
33
Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis. (20506355)
2010
34
A case of bilateral endogenous Pantoea agglomerans endophthalmitis with interstitial lung disease. (20714391)
2010
35
Aspects of interstitial lung disease review series. (20478853)
2010
36
Serum KL-6 levels in lung cancer patients with or without interstitial lung disease. (20872562)
2010
37
Interstitial lung disease - An approach to diagnosis and management. (20369109)
2010
38
Tacrolimus for antisynthetase syndrome with interstitial lung disease? (18591348)
2008
39
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases. (18327397)
2008
40
Respiratory bronchiolitis-associated interstitial lung disease in a nonsmoker: radiologic and pathologic findings. (17449735)
2007
41
In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. (16507114)
2006
42
Characteristics and disease activity of early interstitial lung disease in subjects with true parenchymal abnormalities in the posterior subpleural aspect of the lung. (16478858)
2006
43
c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. (15887294)
2005
44
Familial interstitial lung disease in two young Korean sisters. (16361824)
2005
45
Expression of the thioredoxin system in interstitial lung disease. (14595747)
2003
46
Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases. (10576621)
1999
47
Adhesion molecule expression in the lung: a comparison between normal and diffuse interstitial lung disease. (9543276)
1998
48
Intercellular interactions in morphogenesis of initial lesions and sclerosis in interstitial lung diseases]. (7626980)
1995
49
Mast cells, atypical lymphocytes, and neutrophils in bronchoalveolar lavage in extrinsic allergic alveolitis. Comparison with other interstitial lung diseases. (2432812)
1987
50
Hemodynamic effect of hydralazine in interstitial lung disease patients with cor pulmonale. Immediate and short-term evaluation at rest and during exercise. (3987368)
1985

Variations for Interstitial Lung Disease

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Expression for genes affiliated with Interstitial Lung Disease

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Expression patterns in normal tissues for genes affiliated with Interstitial Lung Disease

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Pathways for genes affiliated with Interstitial Lung Disease

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Compounds for genes affiliated with Interstitial Lung Disease

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 50PharmGKB
See all sources

Compounds related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1infasurf4410.2SFTPB, SFTPC
2popg4410.2SFTPB, SFTPC
31,2-dipalmitoyl-sn-glycero-3-phosphocholine4410.2SFTPB, SFTPC
4dppg4410.2SFTPB, SFTPC
5curosurf4410.2SFTPC, SFTPB
6survanta4410.2SFTPB, SFTPC
7dopc4410.2SFTPB, SFTPC
8dppc4410.2SFTPC, SFTPB
9butanol4410.2SFTPC, SFTPB
10p-opc4410.2SFTPC, SFTPB
11chloroform4410.2SFTPB, SFTPC
12methanol44 2411.1SFTPC, SFTPB
13isoleucine4410.0SFTPC, SFTPB
14peroxynitrite449.9SFTPC, SFTPB
15phosphatidylcholine449.8SFTPC, SFTPD, SFTPB
16phospholipid449.8SFTPC, SFTPD, SFTPB
17doxycycline44 1110.8SFTPC, SFTPB
18larc449.6CCL22, CCL17
19tarc449.5CCL22, CCL17
20ccl344 2810.4CCL17, CCL22
21allergens449.4CCL17, SFTPD
22oxygen44 2410.4SFTPB, SFTPD, SFTPC, IL22
23ccl444 2810.3CCL22, CCL17
24nitric oxide44 24 1111.1SFTPB, SFTPD, CCL17, TAC3
25cysteine448.9SFTPB, SFTPD, SFTPC, CD27
26dexamethasone44 50 28 1111.8SFTPB, SFTPD, SFTPC, CCL17, CCL22
27fibrinogen448.6CCL22, CCL17, CHIT1, SFTPC, SFTPB
28calcium44 50 24 1110.5SFTPB, SFTPD, SFTPC, CCL17, CCL22, TAC3

GO Terms for genes affiliated with Interstitial Lung Disease

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Cellular components related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.3CHIT1, SFTPD, SFTPB
2extracellular spaceGO:0056156.9TAC3, SFTPB, SFTPD, SFTPC, CHIT1, CCL17
3extracellular regionGO:0055766.7SFTPD, SCGB3A2, CCL17, CCL22, IL22, TAC3

Biological processes related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoidGO:0513849.8IL22, SFTPC
2respiratory gaseous exchangeGO:0075859.7SFTPC, SFTPD, SFTPB
3cell chemotaxisGO:0603269.3CCL22, CCL17
4cell-cell signalingGO:0072679.0IL22, CCL22, CCL17
5inflammatory responseGO:0069548.8CCL17, CCL22, IL22
6immune responseGO:0069558.5CCL22, CCL17, CHIT1

Molecular functions related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.3CCL22, CCL17

Products for genes affiliated with Interstitial Lung Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Interstitial Lung Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet