ILD
MCID: INT066
MIFTS: 52

Interstitial Lung Disease (ILD) malady

Respiratory diseases category
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Summaries for Interstitial Lung Disease

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. the inflammation and scarring make it hard to get enough oxygen. the scarring is called pulmonary fibrosis. breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. specific types include black lung disease among coal miners, from inhaling coal dust farmer's lung, from inhaling farm dust asbestosis, from inhaling asbestos fibers siderosis, from inhaling iron from mines or welding fumes silicosis, from inhaling silica dust other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. some types of interstitial lung disease have no known cause. treatment depends on the type of exposure and the stage of the disease. it may involve medicines, oxygen therapy, or a lung transplant in severe cases.

MalaCards: Interstitial Lung Disease, also known as lung diseases, interstitial, is related to lung cancer and pneumonia. An important gene associated with Interstitial Lung Disease is SFTPC (surfactant protein C), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and ERK Signaling. The compounds infasurf and popg have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:65 Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD), refers to a... more...

Aliases & Classifications for Interstitial Lung Disease

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

interstitial lung disease 8 10
lung diseases, interstitial 62
lung diseases interstitial 45
interstitial lung diseases 34
ild 8


External Ids:

Disease Ontology8 DOID:3082
SNOMED-CT58 64667001, 233703007
MeSH35 D017563

Related Diseases for Interstitial Lung Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Interstitial Lung Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.1SFTPB, SFTPD, CCL22, ITGA3
2pneumonia30.8SFTPB, SFTPD, SFTPC, CCL17, CCL22, IL22
3pulmonary fibrosis30.8CCL22, CCL17, SFTPC, SFTPD
4idiopathic pulmonary fibrosis30.6SFTPB, SFTPD, SFTPC, CCL17, CCL22
5respiratory failure30.5SFTPD, SFTPB
6adenocarcinoma30.5SFTPB, SFTPD, SFTPC, ITGA3
7lung adenocarcinoma30.4SFTPC, SFTPD, SFTPB
8sarcoidosis30.2CD27, CHIT1, SFTPD
9cystic fibrosis30.2SFTPB, SFTPD, SFTPC, CCL17, CCL22
10non-small cell lung carcinoma30.1SFTPC, SFTPD, SFTPB
11eosinophilic pneumonia30.1CCL22, CCL17
12asthma29.8SFTPB, SFTPD, SFTPC, SCGB3A2, CHIT1, CCL17
13dermatomyositis10.9
14arthritis10.8
15connective tissue disease10.8
16rheumatoid arthritis10.8
17polymyositis10.8
18scleroderma10.7
19hypertension10.7
20amyopathic dermatomyositis10.7
21bronchiolitis10.7
22respiratory bronchiolitis-associated interstitial lung disease10.6
23children's interstitial lung disease10.6
24antisynthetase syndrome10.5
25myopathy10.4
26myositis10.4
27desquamative interstitial pneumonia10.4
28common variable immunodeficiency10.4
29usual interstitial pneumonia10.4
30mixed connective tissue disease10.3
31colorectal cancer10.3
32esophagitis10.3
33pneumothorax10.3
34pulmonary function10.3
35interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.3
36respiratory bronchiolitis - interstitial lung disease10.3
37nonspecific interstitial pneumonia10.3
38erdheim-chester disease10.3
39hermansky-pudlak syndrome10.3
40idiopathic interstitial pneumonia10.3
41lupus erythematosus10.3
42melanoma10.3
43pancreatitis10.3
44cor pulmonale10.3
45diffuse scleroderma10.2
46dyskeratosis congenita10.2
47obstructive sleep apnea10.2
48sjogren's syndrome10.2
49systemic lupus erythematosus10.2
50eosinophilia10.2

Graphical network of the top 20 diseases related to Interstitial Lung Disease:



Diseases related to interstitial lung disease

Symptoms for Interstitial Lung Disease

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Drugs & Therapeutics for Interstitial Lung Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Interstitial Lung Disease

Search NIH Clinical Center for Interstitial Lung Disease

Genetic Tests for Interstitial Lung Disease

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Anatomical Context for Interstitial Lung Disease

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33MalaCards
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MalaCards organs/tissues related to Interstitial Lung Disease:

33
Lung, Testes, Monocytes, Skin, Brain, T cells, B cells, Thyroid, Endothelial, Breast, Heart, Lymph node, Bone, Smooth muscle

Animal Models for Interstitial Lung Disease or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Interstitial Lung Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9IL22, ITGA3, SFTPC, SFTPD, SFTPB
2MP:00053877.0CD27, SFTPD, SFTPC, CHIT1, CCL17, ITGA3

Publications for Interstitial Lung Disease

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Sources:
52PubMed
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Articles related to Interstitial Lung Disease:

(show top 50)    (show all 709)
idTitleAuthorsYear
1
Subclinical interstitial lung disease: Is it a risk factor for fatal radiation pneumonitis following stereotactic body radiotherapy? (24199683)
2014
2
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma. (23797722)
2013
3
Statins and the risk of interstitial lung disease: a cohort study. (23299962)
2013
4
Anti-CADM-140/MDA5 autoantibody titer correlates with disease activity and predicts disease outcome in patients with dermatomyositis and rapidly progressive interstitial lung disease. (22644102)
2013
5
Severe acute interstitial lung disease after crizotinib therapy in a patient with EML4-ALK-positive non-small-cell lung cancer. (23169500)
2013
6
Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease. (23716070)
2013
7
Riociguat for interstitial lung disease and pulmonary hypertension: a pilot trial. (22936711)
2013
8
Connective Tissue Disease-Associated Interstitial Lung Disease: A Focused Review. (24371251)
2013
9
Natural history of five children with surfactant protein C mutations and interstitial lung disease. (24347114)
2013
10
Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control study. (24038004)
2013
11
Mycophenolate mofetil therapy for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. (23615839)
2013
12
Comparison of characteristics of connective tissue disease-associated interstitial lung diseases, undifferentiated connective tissue disease-associated interstitial lung diseases, and idiopathic pulmonary fibrosis in Chinese Han population: a retrospective study. (24171031)
2013
13
MUC5B and interstitial lung disease. (24029742)
2013
14
Nilotinib-induced interstitial lung disease. (23877149)
2013
15
The clinical significance of HRCT in evaluation of patients with rheumatoid arthritis-associated interstitial lung disease: a report from China. (21132550)
2012
16
Obstructive sleep apnea does not promote esophageal reflux in fibrosing interstitial lung disease. (22521226)
2012
17
Rituximab therapy for refractory interstitial lung disease related to antisynthetase syndrome. (22280877)
2012
18
Interstitial lung disease in connective tissue disorders. (22901890)
2012
19
Subclinical interstitial lung disease: no place for crackles? (22855543)
2012
20
Bronchoalveolar lavage for the evaluation of interstitial lung disease: is it clinically useful? (21540304)
2011
21
Interstitial lung disease in a child heterozygous for the 1549C-->GAA (121ins2) mutation of surfactant protein B. (21965505)
2011
22
Enhanced expression of Fas Ligand (FasL) in the lower airways of patients with fibrotic interstitial lung diseases (ILDs). (22252758)
2011
23
Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease. (21791074)
2011
24
Interstitial lung disease induced or exacerbated by TNF-targeted therapies: analysis of 122 cases. (21277618)
2011
25
IV immunoglobulin might be considered as a first-line treatment of severe interstitial lung disease associated with polymyositis. (21813543)
2011
26
Effect of stem cell therapy on amiodarone induced fibrosing interstitial lung disease in albino rat. (24298346)
2011
27
Interstitial lung disease in children. (21572385)
2011
28
Pulmonary hypertension secondary to interstitial lung disease. (21510729)
2011
29
The impact of rheumatological evaluation in the management of patients with interstitial lung disease. (20685802)
2011
30
Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders? (21273390)
2011
31
Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis. (20506355)
2010
32
A case of bilateral endogenous Pantoea agglomerans endophthalmitis with interstitial lung disease. (20714391)
2010
33
Aspects of interstitial lung disease review series. (20478853)
2010
34
Serum KL-6 levels in lung cancer patients with or without interstitial lung disease. (20872562)
2010
35
Interstitial lung disease - An approach to diagnosis and management. (20369109)
2010
36
Tacrolimus for antisynthetase syndrome with interstitial lung disease? (18591348)
2008
37
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases. (18327397)
2008
38
Respiratory bronchiolitis-associated interstitial lung disease in a nonsmoker: radiologic and pathologic findings. (17449735)
2007
39
In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. (16507114)
2006
40
Characteristics and disease activity of early interstitial lung disease in subjects with true parenchymal abnormalities in the posterior subpleural aspect of the lung. (16478858)
2006
41
c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. (15887294)
2005
42
Familial interstitial lung disease in two young Korean sisters. (16361824)
2005
43
Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. (15297967)
2004
44
Expression of the thioredoxin system in interstitial lung disease. (14595747)
2003
45
Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases. (10576621)
1999
46
Adhesion molecule expression in the lung: a comparison between normal and diffuse interstitial lung disease. (9543276)
1998
47
Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. (9645759)
1998
48
Intercellular interactions in morphogenesis of initial lesions and sclerosis in interstitial lung diseases]. (7626980)
1995
49
Mast cells, atypical lymphocytes, and neutrophils in bronchoalveolar lavage in extrinsic allergic alveolitis. Comparison with other interstitial lung diseases. (2432812)
1987
50
Hemodynamic effect of hydralazine in interstitial lung disease patients with cor pulmonale. Immediate and short-term evaluation at rest and during exercise. (3987368)
1985

Variations for Interstitial Lung Disease

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Expression for genes affiliated with Interstitial Lung Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Interstitial Lung Disease

Search GEO for disease gene expression data for Interstitial Lung Disease.

Pathways for genes affiliated with Interstitial Lung Disease

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Sources:
50PathCards, 54R&D Systems, 55Reactome, 53QIAGEN, 30KEGG
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Compounds for genes affiliated with Interstitial Lung Disease

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB
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Compounds related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1infasurf4510.2SFTPB, SFTPC
2popg4510.2SFTPB, SFTPC
31,2-dipalmitoyl-sn-glycero-3-phosphocholine4510.2SFTPB, SFTPC
4dppg4510.2SFTPB, SFTPC
5curosurf4510.2SFTPC, SFTPB
6survanta4510.2SFTPB, SFTPC
7dopc4510.2SFTPB, SFTPC
8dppc4510.2SFTPC, SFTPB
9butanol4510.2SFTPC, SFTPB
10p-opc4510.2SFTPC, SFTPB
11chloroform4510.2SFTPB, SFTPC
12methanol45 2411.1SFTPC, SFTPB
13isoleucine4510.0SFTPC, SFTPB
14peroxynitrite459.9SFTPC, SFTPB
15phosphatidylcholine459.8SFTPC, SFTPD, SFTPB
16phospholipid459.8SFTPC, SFTPD, SFTPB
17doxycycline45 1110.8SFTPC, SFTPB
18larc459.6CCL22, CCL17
19tarc459.5CCL22, CCL17
20ccl345 2910.4CCL17, CCL22
21allergens459.4CCL17, SFTPD
22oxygen45 2410.4SFTPB, SFTPD, SFTPC, IL22
23ccl445 2910.3CCL22, CCL17
24nitric oxide45 24 1111.1SFTPB, SFTPD, CCL17, TAC3
25cysteine458.9SFTPB, SFTPD, SFTPC, CD27
26dexamethasone45 51 29 1111.8SFTPB, SFTPD, SFTPC, CCL17, CCL22
27fibrinogen458.6CCL22, CCL17, CHIT1, SFTPC, SFTPB
28calcium45 51 24 1110.5SFTPB, SFTPD, SFTPC, CCL17, CCL22, TAC3

GO Terms for genes affiliated with Interstitial Lung Disease

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16Gene Ontology
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Cellular components related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.3CHIT1, SFTPD, SFTPB
2extracellular spaceGO:0056156.9TAC3, SFTPB, SFTPD, SFTPC, CHIT1, CCL17
3extracellular regionGO:0055766.7SFTPD, SCGB3A2, CCL17, CCL22, IL22, TAC3

Biological processes related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoidGO:0513849.8IL22, SFTPC
2respiratory gaseous exchangeGO:0075859.7SFTPC, SFTPD, SFTPB
3cell chemotaxisGO:0603269.3CCL22, CCL17
4cell-cell signalingGO:0072679.0IL22, CCL22, CCL17
5inflammatory responseGO:0069548.8CCL17, CCL22, IL22
6immune responseGO:0069558.5CCL22, CCL17, CHIT1

Molecular functions related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.3CCL22, CCL17

Products for genes affiliated with Interstitial Lung Disease

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Interstitial Lung Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet