Interstitial Lung Disease malady

MedlinePlus: Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. the inflammation and scarring make it hard to get enough oxygen. the scarring is called pulmonary fibrosis. breathing in dust or other particles in the air are responsible for some types of interstitial lung diseases. specific types include black lung disease among coal miners, from inhaling coal dust farmer's lung, from inhaling farm dust asbestosis, from inhaling asbestos fibers siderosis, from inhaling iron from mines or welding fumes silicosis, from inhaling silica dust other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. some types of interstitial lung disease have no known cause. treatment depends on the type of exposure and the stage of the disease. it may involve medicines, oxygen therapy, or a lung transplant in severe cases.²³

MalaCards: Interstitial Lung Disease, also known as interstitial lung diseases, is related to pulmonary hypertension and cystic fibrosis lung disease. An important gene associated with Interstitial Lung Disease is SFTPC (surfactant protein C), and among its related pathways are Chemokine signaling pathway and Chemokine Signaling. The compounds egcg and dmso have been mentioned in the context of this disorder. Affiliated tissues include brain, smooth muscle and lung, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia: Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD), refers to a...⁴⁴ more...

Aliases & Descriptions:

interstitial lung disease 6 8 interstitial lung diseases 17 23 lung diseases, interstitial 43

lung diseases interstitial 32 lung diseases 43 ild 6

Diseases related to interstitial lung disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1040)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary hypertension	33.0	SFTPB, SFTPC, TNC, EDN1, ELANE, NPPB
2	cystic fibrosis lung disease	32.8	IL10, IL1A, IL1B, IL1R1, IL1RN, IL8
3	obstructive lung disease	32.6	SFTPC, ALB, TNF, ACE, ELANE, TGFB1
4	rheumatoid arthritis	31.4	IL1R1, IL1RN, HLA-DRB1, CRP, PRTN3
5	pulmonary surfactant metabolism dysfunction	30.5	SFTPB, SFTPC, ABCA3
6	asthma	30.2	SCGB3A2, IL1B, IL4, IL4R, CCL2, CCL5
7	extrinsic allergic alveolitis	30.2	VTN, SFTPD, IL18, IL1A, IL8, CCL3
8	anthracosis	30.0	BMP6, CCL2, SOD1
9	protein c deficiency	29.6	SFTPC, SERPINC1, F5, PROC, CSF3
10	arthritis	29.5	IL1A, IL1B, IL6, IL8, TNF, TIMP1
11	idiopathic interstitial pneumonia	29.4	SFTPC, SFTPD, IL4R, IL8, CCL2, CCL18
12	usual interstitial pneumonia	29.3	SFTPC, IL8, CCL2, IFNG, TNC, TGFB1
13	pulmonary emphysema	29.3	SFTPD, SERPINB1, MMP7, MMP9, IL18, IL8
14	idiopathic pulmonary fibrosis	29.2	MMP7, IL1B, IL1R1, IL1RN, IL8, IFNG
15	allergic bronchopulmonary aspergillosis	28.7	SFTPD, IL10, IL4, IL5, CCL22, CCR4
16	alpha 1-antitrypsin deficiency	28.6	SFTPB, SERPINC1, SERPINB1, BMP6, IL10, IL8
17	lung adenocarcinoma	28.4	SFTPB, SFTPC, SFTPD, BMP6, MUC1, ITGB1
18	protein s deficiency	28.3	PIK3C2A, SFTPB, SFTPC, SERPINC1, IL2, IL2RA
19	berylliosis	28.3	IL2, IL2RB, IFNG, ALB, HLA-DRB1
20	congestive heart failure	28.3	PIK3C2A, CHKB, TXN, EDN1, ACE, NPPB
21	cork-handlers' disease	28.2	SFTPC, IL1A, IL1RN, IL2, IL6, IL8
22	respiratory failure	28.2	PIK3C2A, SFTPB, SFTPD
23	acute interstitial pneumonia	28.2	PIK3C2A, SFTPC, SFTPD, MMP7, IL4R, CCR4
24	cor pulmonale	28.1	SERPINC1, PAOX, SMOX, EDN1, ACE, SOD1
25	bagassosis	28.0	IL1B, IL5, IL6, IL8, TNF
26	bronchogenic carcinoma	28.0	IL10, IL1RN, IL2, IL2RB, IL3, TNF
27	pulmonary sarcoidosis	27.7	SFTPD, LBR, IL18, IL2, IL2RA, IL2RB
28	cutis laxa	27.2	BMP6, CD79A, FOS, ELANE, TGFB1
29	polymyositis	27.0	PIK3C2A, SFTPD, SELE, CHKB, S100A8, S100A9
30	pulmonary alveolar proteinosis	26.9	SFTPB, SFTPC, SFTPD, MUC1, MMP9, IL10
31	pneumothorax	26.8	SERPINB1, PAOX, MUC1, IL3, SMOX, ACE
32	tuberculosis	26.5	IL10, IL1B, IL1RN, IL4, CCL2, IFNG
33	hepatitis	26.4	IL2RB, ALB, HLA-DRB1, TXN, THPO, TGFB1
34	diffuse panbronchiolitis	26.2	CD79A, IL1B, IL1RAPL2, IL1RN, IL5, IL8
35	panbronchiolitis	26.2	CD79A, IL1B, IL1RAPL2, IL1RN, IL5, IL8
36	legionnaires' disease	26.1	PIK3C2A, ALB, CRP, CXCL10, SLC17A5
37	immunodeficiency	25.9	BMP6, CD79A, CD70, CD4, IL10, IL18
38	candidiasis	25.9	CHIT1, CD79A, CD4, IL10, IL18, IL2
39	pneumoconiosis	25.7	BMP6, IL1A, IL1B, IL1RN, IL2RB, IL4
40	hypercalcemia	25.0	BMP6, IL1A, IL1B, IL2, IL2RB, IL3
41	rheumatoid arthritis, association with	24.8	SELE, CD79A, MMP9, IL10, IL18, IL1B
42	myositis	24.7	PIK3C2A, NARS, CHKB, MMP7, MMP9, FOS
43	iron overload	24.6	BMP6, CHIT1, F5, ALB, HMOX1, TNF
44	pemphigus foliaceus	24.4	CD79A, IL10, IL1A, IL1B, IL1RN, IL4R
45	angiomyolipoma	24.3	KIT, MUC1, IL10, IL1B, IL6, IFNG
46	dermatomyositis	24.2	PIK3C2A, VTN, SFTPD, SELE, BMP6, CHKB
47	aspergillosis	24.2	SFTPD, CD79A, CD4, IL10, IL1A, IL1B
48	chronic obstructive pulmonary disease	24.1	SFTPB, SFTPD, SERPINB1, MMP9, IL6, IL8
49	emphysema	24.0	SFTPB, SFTPC, SFTPD, SERPINB1, BMP6, MMP7
50	intrauterine infections	23.6	IL10, IL1A, IL1B, IL1R1, IL4, IL6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to interstitial lung disease:

²²

MGI Mouse Phenotypes related to interstitial lung disease:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.8	SFTPC, SFTPD, SERPINB1, ITPA, IL12A, CCR2
2	renal/urinary system phenotype	MP:0005367	9.9	TAC1, ABCA3, EGFR, SHH, TNFRSF1B, CASR
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	ADAM17, NKX2-1, IFNG, IL2RB, IL2
4	no phenotypic analysis	MP:0003012	9.6	NKX2-1, EGFR, KRT19, CCR2, CD44, CD4
5	embryogenesis phenotype	MP:0005380	9.4	CSF2, EGFR, SHH, KRT19, IL5, FOSL1
6	hematopoietic system phenotype	MP:0005397	9.1	HGF, IL5, CCR2, CCR4, CASR, HLA-DQA1
7	liver/biliary system phenotype	MP:0005370	8.7	KIT, SERPINC1, IL1R1, IL2, IL6, CCR2
8	digestive/alimentary phenotype	MP:0005381	8.6	EGFR, TGFB1, TFRC, NKX2-1, ADAM17, MMP9
9	skeleton phenotype	MP:0005390	8.3	CASR, TNFRSF1B, SPP1, KRT19, EGFR, CSF2
10	integument phenotype	MP:0010771	8.2	ITPA, FOS, IL1R1, IL2RB, IL4, IL4R
11	nervous system phenotype	MP:0003631	8.1	KRT19, SHH, EDN1, EGFR, TGFB1, TGIF1
12	normal phenotype	MP:0002873	7.6	HLA-DQB1, TNC, TMSB4X, CTSH, SHH, ELANE
13	reproductive system phenotype	MP:0005389	7.2	KRT19, CTSH, SPP1, TNF, SHH, TIMP1
14	immune system phenotype	MP:0005387	7.1	HLA-DQA1, HLA-DQB1, TNF, SHH, EGFR, ELANE
15	growth/size phenotype	MP:0005378	7.1	BMP6, LBR, CD44, ITGB1, ITPA, MMP7
16	muscle phenotype	MP:0005369	6.7	SHH, SPP1, TNFRSF1B, TNF, HLA-DQB1, EDN1
17	mortality/aging	MP:0010768	6.5	ADAM17, PIK3C2A, IL12A, IL1B, IL1R1, IL2RA
18	vision/eye phenotype	MP:0005391	6.3	GLRX2, GLRX, CASR, ICAM1, IFNG, CCL2
19	behavior/neurological phenotype	MP:0005386	6.2	PROC, TAC1, TAC3, ACE, ABCA3, SHH
20	homeostasis/metabolism phenotype	MP:0005376	5.2	CD4, CD44, ITGB1, MMP7, FOS, IL12A
21	tumorigenesis	MP:0002006	5.1	IL10, IL12A, IL1A, IL1B, IL2, IL3
22	cellular phenotype	MP:0005384	3.3	CXCL12, CXCR3, SOD1, CSF2, SLC17A5, NKX2-1
23	cardiovascular system phenotype	MP:0005385	3.1	MMP7, IFNG, F5, ICAM1, GLRX, HMOX1

Articles related to interstitial lung disease:

(show top 50)    (show all 119)

id	Title	Authors	Year	Affiliating Genes
1	Interstitial lung disease induced by gefitinib and to ll-like receptor ligands is mediated by Fra-1. (21460858)	Takada Y.... Matsuo K.	2011	FOSL1
2	Serum ferritin correlates with activity of anti-MDA5 antibody-associated acute interstitial lung disease as a complication of dermat omyositis. (21052763)	Gono T.... Yamanaka H.	2011	IFIH1
3	MRP14 is elevated in the bronchoalveolar lavage fluid of fibrosing interstitial lung diseases. (20550547)	Korthagen N.M.... Grutters J.C.	2010	S100A9
4	Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. (20371530)	Crossno P.F.... Lawson W.E.	2010	ABCA3, SFTPC
5	Serum TARC/CCL17 levels are increased in dermatomyosi tis associated with interstitial lung disease. (20800454)	Kawashima T.... Sato S.	2010	CCL17
6	Antifibroblast antibodies from systemic sclerosis pat ients bind to {alpha}-enolase and are associated with interstitial lung disease . (19293162)	Terrier B.... Mouthon L.	2010	ENO1
7	NKX2-1 mutations leading to surfactant protein promot er dysregulation cause interstitial lung disease in 'Brain-Lung-Thyroid Sy ndrome'. (20020530)	Guillot L.... Epaud R.	2010	NKX2-1
8	Elevated brain natriuretic peptide predicts mortality in interstitial lung disease. (20223915)	Corte T.J.... Wells A.U.	2010	NPPB
9	Endothelin-1 and brain natriuretic peptide in the de velopment of pulmonary hypertension in interstitial lung diseases (20481052)	Fomin V.V.... Mukhin N.A.	2009	EDN1, NPPB
10	Bronchoalveolar lavage fluid cellular characteristics, functional parameters and cytokine and chemokine levels in interstitial lung diseases. (19281539)	Vasakova M.... Striz I.	2009	IFNG, CCL5, THPO
11	RNA helicase encoded by melanoma differentiation-asso ciated gene 5 is a major autoantigen in patients with clinically amyopathic der matomyositis: Association with rapidly progressive interstitial lung disease. (19565506)	Sato S.... Kuwana M.	2009	IFIH1
12	Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3. (19292764)	Armstrong L.... Millar A.B.	2009	TNF, ADAM17, PRTN3
13	Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases. (19117745)	Vasakova M.... Striz I.	2009	TGFB1, TNF, IL6
14	TH1/TH2 immune response in lung fibroblasts in interstitial lung disease. (18514095)	Sumida A.... Kawabe T.	2008	CXCR3, CCR4, CCL22
15	The serum levels of cytokines in patients with rheumatoid arthritis associated interstitial lung disease and their clinical significance (18846962)	Ji Y.X.... Li J.L.	2008	TGFB1, MMP9
16	Calgranulin B (S100A9) levels in bronchoalveolar lavage fluid of patients with interstitial lung diseases. (18784990)	Bargagli E.... Rottoli P.	2008	S100A8, S100A9
17	Independent review of interstitial lung disease associated with death in TRIBUTE (paclitaxel and carboplatin with or without concurrent erlotinib) in advanced non-small cell lung cancer. (17545850)	Yoneda K.Y.... Gandara D.R.	2007	EGFR
18	Peripheral-type benzodiazepine receptors in bronchoal veolar lavage cells of patients with interstitial lung disease. (17591555)	Branley H.M.... Jones H.A.	2007	TSPO
19	Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. (17174272)	Mehrad B.... Strieter R.M.	2007	CXCL12
20	Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases. (17696954)	Vuorinen K.... Kinnula V.L.	2007	MMP7
21	Readministration of gefitinib in a responder after treatment discontinuation due to gefinitib-related interstitial lung disease: a case report. (18021415)	Takamochi K.... Funai K.	2007	EGFR
22	In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. (16507114)	Chinoy H.... Cooper R.G.	2006	HLA-DQA1, HLA-DQB1, HLA-DRB1
23	Genetics of pediatric interstitial lung disease. (16721150)	Nogee L.M.	2006	SFTPC
24	Interstitial lung disease associated with gefitinib. (16137874)	Kataoka K.... Shimokata K.	2006	EGFR
25	Treatment of antisynthetase-associated interstitial lung disease with tacrolimus. (16052580)	Wilkes M.R.... Oddis C.V.	2005	CHKB
26	A role for MCP-1/CCR2 in interstitial lung disease in children. (16095529)	Hartl D.... Krauss-Etschmann S.	2005	CCL2, CCR2
27	ABCA3 mutations associated with pediatric interstitial lung disease. (15976379)	Bullard J.E.... Nogee L.M.	2005	ABCA3, SFTPB
28	Interstitial lung disease in children -- genetic background and associated phenotypes. (15819986)	Hartl D.... Griese M.	2005	SFTPB
29	Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. (15297967)	Peltoniemi M.... Kinnula V.L.	2004	BMP6, GLRX, GLRX2
30	Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene. (15293602)	Brasch F.... Beers M.F.	2004	SFTPC
31	BAL cytokine profile in different interstitial lung diseases: a focus on systemic sclerosis. (15281432)	Meloni F.... Montecucco C.	2004	CCL2, IL8, IL18
32	Mutations in the surfactant protein C gene associated with interstitial lung disease. (11893657)	Nogee L.M.... Whitsett J.A.	2002	SFTPC
33	Clinical significance of serum surfactant protein D (SP-D) in patients with polymyositis/dermatomyositis: correlation with interstitial lung disease. (12421999)	Ihn H.... Tamaki K.	2002	SFTPD
34	Arterial endothelin-1 in interstitial lung disease patients with pulmonary hypertension. (11887493)	Trakada G.... Spiropoulos K.	2001	EDN1
35	Morphological and biochemical properties of alveolar fibroblasts in interstitial lung diseases. (11733853)	Fireman E.... Grief J.	2001	PIK3C2A
36	Human bronchoalveolar lavage fluid protein two-dimensional database: study of interstitial lung diseases. (10949149)	Wattiez R.... Falmagne P.	2000	SCGB3A2
37	Extensive surface phenotyping of alveolar macrophages in interstitial lung disease. (10607488)	Taylor M.L.... Bochner B.S.	2000	ITGB1, CD44, TFRC
38	Tachykinin activation of human monocytes from patients with interstitial lung disease, healthy smokers or healthy volunteers. (10688968)	Brunelleschi S.... Albera C.	2000	TAC1, TAC3
39	Interleukin 5 and granulocyte-macrophage colony-stimulating factor levels in bronchoalveolar lavage fluid in interstitial lung disease. (11153599)	Taniguchi H.... Kohno S.	2000	IL3, CSF2, IL5
40	Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. (9645759)	Fukuda Y.... Yamanaka N.	1998	TIMP1
41	Expression of RANTES by bronchoalveolar lavage cells in nonsmoking patients with interstitial lung diseases. (9533940)	Kodama N.... Kawakami Y.	1998	CCL5
42	Protein C anticoagulant system in patients with interstitial lung disease. (9620917)	Kobayashi H.... Adachi Y.	1998	PROC
43	Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation (9369919)	Ishioka S.	1997	ELANE
44	Quantitative evaluation of the IL-1 beta and IL-1 receptor antagonist obtained from BALF macrophages in patients with interstitial lung diseases. (9186988)	Mikuniya T.... Izumi T.	1997	IL1B, IL1RAPL2
45	Endothelin-1 excretion in urine in active pulmonary sarcoidosis and in other interstitial lung diseases. (8532958)	Sofia M.... CarratA^ L.	1995	EDN1
46	Spontaneous heat shock protein synthesis by alveolar macrophages in interstitial lung disease associated with phagocytosis of eosinophils. (8491297)	Polla B.S.... Junod A.F.	1993	HMOX1
47	Suppressive mechanisms of alveolar macrophages in interstitial lung diseases: role of soluble factors and cell-to-cell contact. (8370444)	Fireman E.... Greif J.	1993	IL2RA, IL2, IL2RB
48	Macrophage inflammatory protein-1 alpha expression in interstitial lung disease. (8360496)	Standiford T.J.... Strieter R.M.	1993	IL1B, CCL3
49	Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study. (1596025)	Kaplan J.D.... Schuster D.P.	1992	TF
50	Vitronectin in bronchoalveolar lavage fluid is increased in patients with interstitial lung disease. (1710880)	Pohl W.R.... Rennard S.I.	1991	VTN

Genes related to interstitial lung disease according to GeneCards:

(show top 50)    (show all 117)

id	Symbol	Description	Score	GeneCards Section Context
1	SFTPC	surfactant protein C	11.1	Publications, Summaries
2	HADHAP1	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit pseudogene 1	11.0	Publications
3	SCGB3A2	secretoglobin, family 3A, member 2	11.0	Publications
4	SFTPD	surfactant protein D	11.0	Publications
5	STK16	serine/threonine kinase 16	11.0	Publications
6	TMSB10	thymosin beta 10	11.0	Publications
7	NARS	asparaginyl-tRNA synthetase	11.0	Publications
8	GLRX2	glutaredoxin 2	11.0	Publications
9	SFTPB	surfactant protein B	11.0	Publications
10	HARS	histidyl-tRNA synthetase	11.0
11	GLRX	glutaredoxin (thioltransferase)	11.0	Publications
12	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	11.0	Publications
13	CD70	CD70 molecule	11.0	Publications
14	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	11.0	Publications
15	TMSB4X	thymosin beta 4, X-linked	11.0	Publications
16	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0	Publications
17	PAOX	polyamine oxidase (exo-N4-amino)	11.0
18	TAC3	tachykinin 3	11.0	Publications
19	CXCL5	chemokine (C-X-C motif) ligand 5	11.0	Publications
20	HABP2	hyaluronan binding protein 2	11.0	Publications
21	IFIH1	interferon induced with helicase C domain 1	11.0	Publications
22	FOSL1	FOS-like antigen 1	11.0	Publications
23	CTSH	cathepsin H	11.0	Publications
24	ITPA	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	11.0	Publications
25	S100A9	S100 calcium binding protein A9	11.0	Publications
26	CCL22	chemokine (C-C motif) ligand 22	11.0	Publications
27	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
28	CD27	CD27 molecule	11.0	Publications
29	CHIT1	chitinase 1 (chitotriosidase)	11.0	Publications
30	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
31	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
32	ABCA3	ATP-binding cassette, sub-family A (ABC1), member 3	11.0	Publications
33	PRTN3	proteinase 3	11.0	Publications
34	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.0	Publications
35	NKX2-1	NK2 homeobox 1	11.0	Publications
36	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	11.0	Publications
37	SHH	sonic hedgehog	11.0	Publications
38	SMOX	spermine oxidase	11.0
39	AARS	alanyl-tRNA synthetase	11.0
40	CCR2	chemokine (C-C motif) receptor 2	11.0	Publications
41	THPO	thrombopoietin	11.0	Publications
42	ENO1	enolase 1, (alpha)	11.0	Publications
43	IL4R	interleukin 4 receptor	11.0	Publications
44	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
45	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
46	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
47	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
48	TSPO	translocator protein (18kDa)	11.0	Publications
49	IL2RB	interleukin 2 receptor, beta	11.0	Publications
50	CHKB	choline kinase beta	11.0	Publications

Pathways related to interstitial lung disease according to GeneDecks:

(show top 50)    (show all 135)

id	Pathway	Score	Top Affiliating Genes
1	Chemokine signaling pathway20	9.9	IL8, CCL4, CCR2, CCL22, CCL2, CCR4
2	Chemokine Signaling36	9.9	FOS, IL8, CCL4, CCR2, CCL22, CCL2
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	IL2, IL2RA, IL2RB, CCL4, CCL3, CSF2
4	RAR-Gamma-RXR-Alpha Degradation36	9.5	IL12A, IL2, IL3, CCL4, CCL22, CCL17
5	Transendothelial Migration of Leukocytes36	9.2	ITGB1, MMP7, MMP9, IL8, CCL4, CCR2
6	NFAT Signaling and Lymphocyte Interactions36	9.2	BMP6, CD4, IL12A, IL1A, IL2, IL2RB
7	Immune System38	8.9	CD79A, IL18, IL1R1, IL3, IL5, CCR2
8	Regulation of eIF4 and p70S6K36	8.9	CD4, ITGB1, IL12A, IL18, IL1A, IL2
9	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	IL10, IL12A, IL2, IL2RA, IL2RB, TNF
10	IL-6 Pathway36	8.8	BMP6, IL10, IL12A, IL18, IL3, IL4
11	PGC1Alpha Pathway36	8.6	BMP6, CD4, IL12A, IL18, IL1A, IL1B
12	JNK Pathway36	8.5	KIT, BMP6, CD4, IL1R1, IL2, IL2RA
13	Allograft rejection20	8.4	IL10, IL12A, IL2, IL4, IL5, IFNG
14	Intestinal immune network for IgA production20	8.3	IL10, IL2, IL4, IL5, IL6, HLA-DQA1
15	Leishmaniasis20	8.2	ITGB1, FOS, IL10, IL12A, IL1A, IL1B
16	Molecular Mechanisms of Cancer36	8.2	BMP6, CD4, ITGB1, FOS, IL1R1, IL2
17	THC Differentiation Pathway36	8.1	IL10, IL12A, IL18, IL2, IL2RA, IL4
18	Toll-like receptor signaling pathway20	8.0	FOS, IL12A, IL1B, IL6, IL8, CCL4
19	African trypanosomiasis20	8.0	SELE, IL10, IL12A, IL18, IL1B, IL6
20	SOCS Pathway36	8.0	BMP6, CD4, IL10, IL12A, IL18, IL1A
21	Influenza A20	7.8	IL12A, IL18, IL1A, IL1B, IL6, IL8
22	Chagas disease (American trypanosomiasis)20	7.8	FOS, IL10, IL12A, IL1B, IL6, CCL2
23	Malaria20	7.6	SELE, IL10, IL12A, IL18, IL1B, IL6
24	NFAT in Immune Response36	7.6	KIT, BMP6, CD79A, CD4, FOS, IL2
25	Endothelin-1 Signaling Pathway36	7.5	KIT, BMP6, IL10, IL12A, IL18, IL1A
26	NF-KappaB (p50-p65) Pathway36	7.5	BMP6, IL1A, IL1B, IL1R1, IL2, IL3
27	Apoptotic Pathways in Synovial Fibroblasts36	7.5	KIT, BMP6, IL2, IL2RA, IL3, IL6
28	PPAR Pathway36	7.5	KIT, ITGB1, IL2, IL2RA, IL3, IL6
29	NF-KappaB Family Pathway36	7.4	BMP6, IL1A, IL1B, IL1R1, IL2, IL3
30	Cytokine Network36	7.3	IL10, IL12A, IL18, IL1A, IL1B, IL2
31	Rheumatoid arthritis20	7.3	FOS, IL18, IL1A, IL1B, IL6, IL8
32	Glucocorticoid Receptor Signaling36	7.3	BMP6, CD4, FOS, IL10, IL12A, IL18
33	Akt Signaling36	7.2	KIT, CD4, IL10, IL18, IL2, IL2RA
34	Hematopoietic cell lineage20	7.2	KIT, CD4, CD44, IL1A, IL1B, IL1R1
35	ERK Signaling36	7.1	KIT, BMP6, ITGB1, IL10, IL12A, IL18
36	Rho Family GTPases36	7.1	KIT, BMP6, ITGB1, FOS, IL10, IL12A
37	Tec Kinases Signaling36	7.0	BMP6, CD4, ITGB1, FOS, IL10, IL12A
38	all-trans-Retinoic Acid Signaling in Brain36	6.8	BMP6, IL10, IL12A, IL18, IL1A, IL1B
39	MIF Mediated Glucocorticoid Regulation36	6.8	BMP6, IL10, IL12A, IL18, IL1A, IL1B
40	TGF-Beta Pathway36	6.7	BMP6, CD4, FOS, IL10, IL12A, IL18
41	MAPK Signaling36	6.7	KIT, BMP6, ITGB1, FOS, IL1A, IL1B
42	MIF Regulation of Innate Immune Cells36	6.6	BMP6, FOS, IL10, IL12A, IL18, IL1A
43	PEDF Induced Signaling36	6.6	BMP6, FOS, IL10, IL12A, IL18, IL1A
44	MAPK Family Pathway36	6.2	BMP6, CD4, IL10, IL12A, IL18, IL1A
45	STAT3 Pathway36	6.1	BMP6, CD4, IL10, IL12A, IL18, IL1A
46	JAK-STAT Pathway36	6.1	KIT, BMP6, CD4, FOS, IL10, IL12A
47	PAK Pathway36	5.8	KIT, BMP6, IL10, IL12A, IL18, IL1A
48	p38 Signaling36	5.4	KIT, BMP6, CD4, FOSL1, IL10, IL12A
49	Cytokine-cytokine receptor interaction20	5.3	KIT, CD27, CD70, IL10, IL12A, IL18
50	Antioxidant Action of Vitamin-C36	5.3	KIT, BMP6, CD4, FOS, IL10, IL12A

Compounds related to interstitial lung disease according to GeneDecks:

(show top 50)    (show all 451)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.4	IL1A, CCL5, ELANE, TIMP1, SOD1
2	dmso32	10.4	BMP6, S100A9, MMP7, THPO, TAC1, PRTN3
3	sodium nitroprusside32	10.0	PIK3C2A, BMP6, IL5, HMOX1, ELANE, TF
4	polyethylene glycol32	10.0	VTN, SELE, SERPINC1, CHKB, MUC1, HMOX1
5	ascorbic acid32 18	10.6	SFTPB, CHKB, FOSL1, IL1A, IL1R1, IL2RA
6	estrogen32	9.5	SERPINC1, CHKB, IL18, IL1RN, CASR, GLRX
7	ccl432	9.4	IL1R1, CCL4, CCL22, CCL2, CCR4, CCL17
8	allergens32	9.1	SFTPD, S100A8, CD79A, IL10, IL18, IL1RN
9	methylcellulose32	9.1	KIT, IL1A, IL3, IL4, IL5, IL6
10	cuprophan32	9.1	VTN, LBR, IL1B, IL1R1, IL1RAPL2, IL1RN
11	epinephrine32 9 18 9	11.7	PIK3C2A, VTN, SELE, BMP6, CHKB, LBR
12	pge232	8.7	VTN, SFTPB, SELE, CD4, IL1A, IL1R1
13	h2o232	8.6	SERPINB1, LBR, S100A9, CD79A, IL18, IL1RAPL2
14	12-o-tetradecanoylphorbol 13-acetate32	8.6	SFTPB, BMP6, LBR, CD4, CD44, ITGB1
15	con a32	8.6	LBR, CD79A, IL10, IL18, IL2, IL2RA
16	methacholine32 9 9	10.5	CD79A, IL2RB, IL4, IL5, IL8, CCL22
17	p00232	8.5	KIT, CD44, MMP7, MMP9, IL18, IL1RN
18	calcitriol32 42 9 18 9	12.4	BMP6, S100A8, S100A9, CD44, ITGB1, FOS
19	polysaccharide32	8.3	VTN, SFTPD, SELE, SERPINC1, BMP6, CHIT1
20	zidovudine32 9 9	10.2	LBR, CD4, IL10, IL2, IL3, CCL2
21	glutamate32	8.2	VTN, BMP6, S100A8, CD79A, CD4, MMP9
22	arginine32	8.1	PIK3C2A, VTN, SFTPB, SFTPC, SERPINC1, CHKB
23	amphotericin b32	8.0	IL1R1, IL1RAPL2, IL1RN, IL4, IL5, CCL4
24	cysteine32	7.8	VTN, SFTPB, SFTPC, SFTPD, CHKB, MUC1
25	ribavirin32 34 9 9	10.7	LBR, ITPA, MMP9, IL10, IL18, IL2
26	chloramphenicol32 9 9	9.7	SFTPB, SFTPC, SELE, SERPINC1, MUC1, LBR
27	sulfasalazine32 9 9	9.6	SELE, CD79A, IL1A, IL1B, IL1R1, IL1RAPL2
28	curcumin32	7.6	VTN, MMP9, FOS, IL18, IL1A, IL1B
29	15-deoxy-delta-12,14-prostaglandin j232	7.6	BMP6, FOS, IL10, IL1B, IL4, IL6
30	calcium32 9 18 9	10.3	PIK3C2A, KIT, VTN, SFTPB, SFTPC, SFTPD
31	atorvastatin32 34 9 18 9	11.3	PIK3C2A, SELE, BMP6, CHKB, MMP9, IL10
32	gabexate mesilate32	7.3	SELE, SERPINC1, MMP9, IL10, IL6, IL8
33	pdtc32	7.1	SFTPB, SELE, MMP9, FOS, FOSL1, IL18
34	8-isoprostane32	7.1	SELE, MMP9, IL10, IL6, IL8, CCL2
35	vitamin d32	7.0	BMP6, CHKB, LBR, CD79A, CD44, IL10
36	sb 20358032 42	7.9	SELE, BMP6, ITGB1, MMP9, FOS, FOSL1
37	fibrinogen32	6.6	PIK3C2A, VTN, SFTPB, SFTPC, SELE, SERPINC1
38	pd 98,05932	6.4	KIT, VTN, BMP6, ITGB1, MMP9, FOS
39	ccl332	6.4	MMP9, IL10, IL18, IL1A, IL1B, IL1R1
40	pentoxifylline32 9 9	8.1	BMP6, LBR, IL10, IL18, IL1A, IL1B
41	norepinephrine32 9 18 9	9.0	PIK3C2A, SELE, BMP6, CHKB, LBR, CD79A
42	infliximab32 9 9	8.0	SELE, LBR, IL10, IL18, IL1B, IL1R1
43	cholesterol32 9 18 9	8.9	PIK3C2A, VTN, SFTPB, SFTPC, SFTPD, SELE
44	simvastatin32 34 42 9 18 9	10.9	PIK3C2A, SELE, BMP6, CHKB, MMP9, IL10
45	lipid32	5.7	PIK3C2A, VTN, SFTPB, SFTPC, SFTPD, SELE
46	alanine32	5.6	PIK3C2A, VTN, SELE, SERPINC1, BMP6, CHKB
47	genistein32 9 18 9	8.4	SELE, LBR, CD4, ITGB1, MMP9, FOS
48	retinoic acid32 42 18	6.7	KIT, VTN, SFTPB, SFTPC, BMP6, LBR
49	thymidine32 18	5.7	KIT, SFTPB, SFTPD, BMP6, CHKB, MUC1
50	neopterin32	4.4	CHIT1, CHKB, LBR, CD79A, CD4, IL10

Cellular components related to interstitial lung disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.4	HGF, TGFB1, TIMP1, TMSB4X, ALB, F5
2	membrane raft	GO:045121	9.1	ADAM17, EGFR, SHH, TNFRSF1B, TNF, ITGB1
3	integral to plasma membrane	GO:005887	8.6	CASR, HLA-DQA1, HLA-DRB1, TNF, TNFSF8, TFRC
4	external side of plasma membrane	GO:009897	7.3	CD4, CD44, ITGB1, IL2RB, IL4, CCR4
5	plasma membrane	GO:005886	5.9	SHH, TNFRSF1B, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
6	extracellular region	GO:005576	4.4	SERPINC1, CCL2, CCL17, CCL3, CCL5, IFNG
7	extracellular space	GO:005615	1.8	KIT, IL1A, IL1B, IL1RN, IL2, IL3

Biological processes related to interstitial lung disease according to GeneDecks:

(show top 50)    (show all 70)

id	Name	GO ID	Score	Top Affiliating Genes
1	macrophage chemotaxis	GO:048246	10.5	SFTPD, CCL2, CCL3, CCL5
2	chemokine-mediated signaling pathway	GO:070098	10.5	CXCR3, CXCL12, CCL5, CCR4, CCL2, CCR2
3	positive regulation of cell migration	GO:030335	10.2	ADAM17, TGFB1, EGFR, EDN1, CTSH, CCL5
4	cellular calcium ion homeostasis	GO:006874	10.2	CXCL12, TGFB1, ELANE, CASR, CCL5, CCL3
5	cellular response to tumor necrosis factor	GO:071356	10.2	EDN1, ICAM1, CCL5, CCL3, CCL2, IL8
6	chemotaxis	GO:006935	10.1	CXCR3, CXCL9, CXCL5, S100A8, S100A9, FOSL1
7	negative regulation of T cell proliferation	GO:042130	10.1	TGFB1, SHH, HLA-DRB1, IL10, SFTPD
8	response to lipopolysaccharide	GO:032496	10.1	SFTPB, SFTPC, SELE, S100A8, S100A9, MMP9
9	cellular response to interleukin-1	GO:071347	10.0	EDN1, ICAM1, CCL5, CCL3, CCL2, IL8
10	positive regulation of gene expression	GO:010628	10.0	NKX2-1, CSF2, TGFB1, CTSH, CCL5, CCL3
11	response to ethanol	GO:045471	9.9	NKX2-1, SOD1, SHH, ICAM1, CCL2, IL4
12	regulation of vascular endothelial growth factor production	GO:010574	9.9	CCL2, CCR2, IL6
13	response to radiation	GO:009314	9.9	CXCL12, TGFB1, TXN, IL18, MMP9, KIT
14	positive regulation of neuron differentiation	GO:045666	9.8	CXCL12, TGIF1, IFNG, CCL5, ITGB1, BMP6
15	neutrophil chemotaxis	GO:030593	9.8	EDN1, SPP1, IFNG, CCL3, CCL2, IL8
16	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	TGFB1, TNF, CCL5, CCL3, CCL2, IL1B
17	protein kinase B signaling cascade	GO:043491	9.7	TGFB1, TNF, CCL5, CCL3, CCL2, IL1B
18	cellular response to organic cyclic compound	GO:071407	9.7	TGFB1, TNF, CCL5, CCL3, CCL2, IL1B
19	platelet degranulation	GO:002576	9.7	HGF, SOD1, TF, TGFB1, TIMP1, TMSB4X
20	cell surface receptor signaling pathway	GO:007166	9.7	NPPB, CXCL10, EGFR, EDN1, IFNG, CCL2
21	calcium-mediated signaling	GO:019722	9.6	CXCR3, EDN1, TNF, CCL3, IL8, SELE
22	cellular response to lipopolysaccharide	GO:071222	9.6	TSPO, TNFRSF1B, ICAM1, IFNG, CCL2, IL8
23	response to virus	GO:009615	9.5	CXCL12, TNF, IFNG, IFIH1, CCL5, CCL22
24	elevation of cytosolic calcium ion concentration	GO:007204	9.5	CXCR3, TAC1, EDN1, CCR4, CCR2, IL2
25	MAPK cascade	GO:000165	9.5	TGFB1, EGFR, TNF, CCL5, CCL3, CCL2
26	positive regulation of podosome assembly	GO:071803	9.5	TNF, IL5, CSF2
27	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	HGF, IL6, IL5, IL3, ITGB1, CD44
28	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.5	CSF2, IL4, IL3, IL2, KIT
29	response to activity	GO:014823	9.5	TNF, CCL5, CCL2, IL10, ITGB1
30	positive regulation of interferon-gamma production	GO:032729	9.4	TNF, CCR2, IL2, IL1B, IL18, IL12A
31	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	ELANE, EDN1, TNF, HMOX1, CCL5, IL6
32	positive regulation of T cell proliferation	GO:042102	9.3	IFNG, CCL5, IL6, IL4, IL1B, IL12A
33	cell adhesion	GO:007155	9.3	HABP2, ADAM17, CXCR3, CXCL12, SPP1, TNC
34	cell-cell signaling	GO:007267	9.3	IL2, IL3, CCL4, CCL22, CCL17, CCL3
35	blood coagulation	GO:007596	9.2	HGF, SOD1, PROC, TF, TGFB1, THPO
36	positive regulation of chemokine biosynthetic process	GO:045080	9.2	TNF, HMOX1, IFNG, IL4, IL1B
37	signal transduction	GO:007165	9.1	CCL18, TXN, TNC, TNFSF8, EGFR, CXCL10
38	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	IFNG, ICAM1, TNF, EDN1, EGFR, IL1B
39	platelet activation	GO:030168	9.0	HGF, SOD1, TF, TGFB1, THPO, TIMP1
40	response to glucocorticoid stimulus	GO:051384	9.0	TNF, CCL5, CCL2, IL6, IL1RN, IL1B
41	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	8.9	TNF, IFNG, IL1B
42	anti-apoptosis	GO:006916	8.6	HGF, ADAM17, SOD1, TNF, HMOX1, CCL2
43	positive regulation of cell proliferation	GO:008284	8.4	THPO, TGFB1, PRTN3, CXCL10, CXCL5, CSF2
44	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.3	TNF, IL6, IL5, IL4, IL1B, IL10
45	cytokine-mediated signaling pathway	GO:019221	8.2	IFNG, ICAM1, HLA-DQA1, HLA-DQB1, HLA-DRB1, CSF3
46	response to hypoxia	GO:001666	8.2	SHH, EDN1, TGFB1, CXCL12, NPPB, ADAM17
47	response to drug	GO:042493	8.1	MMP9, FOSL1, IL10, IL1RN, IL4, CCL2
48	negative regulation of apoptotic process	GO:043066	8.1	CSF2, CXCL12, PROC, TIMP1, EGFR, SHH
49	immune response	GO:006955	7.7	VTN, CCR2, CCL22, CCR4, CCL17, CCL18
50	inflammatory response	GO:006954	6.6	KIT, SELE, CCL18, CCL5, TNF, TNFRSF1B

Molecular functions related to interstitial lung disease according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	CCR5 chemokine receptor binding	GO:031730	10.4	CCL4, CCL3, CCL5
2	chemokine activity	GO:008009	10.0	CXCL9, IL8, CCL4, CCL22, CCL2, CCL17
3	receptor binding	GO:005102	9.8	NPPB, CXCL12, CXCL10, TAC3, TNFSF8, TNC
4	transmembrane signaling receptor activity	GO:004888	9.3	EGFR, ICAM1, IL1R1, CD44, CD4, CD27
5	protease binding	GO:002020	9.2	ELANE, TNF, IL1R1, ITGB1, CD70, SERPINC1
6	growth factor activity	GO:008083	7.5	THPO, TGFB1, CXCL12, CSF2, CSF3, HGF
7	cytokine activity	GO:005125	6.7	THPO, CXCL9, CSF2, CSF3, EDN1, SPP1
8	protein binding	GO:005515	4.1	SHH, KRT19, CRP, CTSH, TMSB4X, TNFRSF1B