ILD
MCID: INT066
MIFTS: 53

Interstitial Lung Disease (ILD) malady

Respiratory diseases category

Summaries for Interstitial Lung Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. the inflammation and scarring make it hard to get enough oxygen. the scarring is called pulmonary fibrosis. breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. specific types include black lung disease among coal miners, from inhaling coal dust farmer's lung, from inhaling farm dust asbestosis, from inhaling asbestos fibers siderosis, from inhaling iron from mines or welding fumes silicosis, from inhaling silica dust other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. some types of interstitial lung disease have no known cause. treatment depends on the type of exposure and the stage of the disease. it may involve medicines, oxygen therapy, or a lung transplant in severe cases.

MalaCards: Interstitial Lung Disease, also known as lung diseases, interstitial, is related to rheumatoid arthritis and arthritis. An important gene associated with Interstitial Lung Disease is SFTPC (surfactant protein C), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds calcium and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related mouse phenotype immune system.

Wikipedia:63 Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD), refers to a... more...

Aliases & Classifications for Interstitial Lung Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

interstitial lung disease 8 10
lung diseases, interstitial 60
lung diseases interstitial 44
interstitial lung diseases 33
ild 8


External Ids:

Disease Ontology8 DOID:3082
SNOMED-CT56 233703007, 64667001
MeSH34 D017563

Related Diseases for Interstitial Lung Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Interstitial Lung Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis31.2CCL18, SFTPD, S100A9, CD70, CD27, CXCL5
2arthritis31.2S100A9, CXCL5, CXCL9
3pneumonia31.0CCL22, CCL18, SFTPC, SFTPD, SFTPB, CXCL5
4pulmonary fibrosis30.9SFTPD, SFTPC, CCL18, CCL22
5idiopathic pulmonary fibrosis30.7CCL22, SFTPC, SFTPD, SFTPB, CXCL5, CXCL9
6melanoma30.4ITGA3, CD70, CD27, CXCL5, CXCL9
7skin disease30.4CXCL9
8respiratory failure30.4SFTPC, SFTPD, SFTPB
9lupus erythematosus30.4CD70
10sarcoidosis30.2CCL18, SFTPD, S100A9, CHIT1, CD27, CXCL5
11cystic fibrosis30.2S100A9, SFTPB, SFTPD, SFTPC, CCL22
12extrinsic allergic alveolitis30.2CXCL5, SFTPD
13asthma30.0CCL22, SFTPC, SFTPD, SFTPB, SCGB3A2, CHIT1
14influenza30.0CCL18, SFTPD, CD27, CXCL9
15pulmonary sarcoidosis30.0CXCL9, CXCL5, SFTPD
16multiple sclerosis30.0CHIT1, CD27, CXCL9
17uveitis30.0CXCL9
18tuberculosis30.0CXCL9, SFTPD
19non-small cell lung carcinoma30.0SFTPB, SFTPD, SFTPC
20dermatomyositis11.0
21rheumatoid lung disease10.8
22connective tissue disease10.8
23lung cancer10.8
24scleroderma10.7
25hypertension10.7
26bronchiolitis10.7
27respiratory bronchiolitis-associated interstitial lung disease10.7
28myopathy10.4
29myositis10.4
30desquamative interstitial pneumonia10.4
31common variable immunodeficiency10.4
32pulmonary systemic sclerosis10.4
33interstitial emphysema10.3
34mixed connective tissue disease10.3
35adenocarcinoma10.3
36esophageal disease10.3
37esophagitis10.3
38idiopathic interstitial pneumonia10.3
39lung adenocarcinoma10.3
40obstructive lung disease10.3
41pneumothorax10.3
42vascular disease10.3
43colorectal cancer10.3
44children's interstitial lung disease10.3
45interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.3
46nonspecific interstitial pneumonia10.3
47diffuse scleroderma10.3
48erdheim-chester disease10.3
49adult dermatomyositis10.3
50hermansky-pudlak syndrome10.3

Graphical network of the top 20 diseases related to Interstitial Lung Disease:



Diseases related to interstitial lung disease

Clinical Features for Interstitial Lung Disease

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Drugs & Therapeutics for Interstitial Lung Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Interstitial Lung Disease

Drug clinical trials:

Search ClinicalTrials for Interstitial Lung Disease

Search NIH Clinical Center for Interstitial Lung Disease

Search CenterWatch for Interstitial Lung Disease

Genetic Tests for Interstitial Lung Disease

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Anatomical Context for Interstitial Lung Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Interstitial Lung Disease:

32
Lung, Testes, Monocytes, Brain, T cells, Skin, Endothelial, Heart, B cells, Thyroid, Breast, Smooth muscle, Lymph node, Bone

Animal Models for Interstitial Lung Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Interstitial Lung Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6IL27, CXCL9, CD27, CD70, CHIT1, ITGA3

Publications for Interstitial Lung Disease

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Sources:
50PubMed
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Articles related to Interstitial Lung Disease:

(show top 50)    (show all 729)
idTitleAuthorsYear
1
Subclinical interstitial lung disease: Is it a risk factor for fatal radiation pneumonitis following stereotactic body radiotherapy? (24199683)
2014
2
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma. (23797722)
2013
3
Severe acute interstitial lung disease after crizotinib therapy in a patient with EML4-ALK-positive non-small-cell lung cancer. (23169500)
2013
4
Both gefitinib and erlotinib induced drug-related interstitial lung disease in a patient with pulmonary adenocarcinoma. (23497972)
2013
5
Interstitial lung disease in inflammatory myopathies: clinical phenotypes and prognosis. (23888366)
2013
6
Interstitial lung disease as an unusual presenting symptom in juvenile dermatomyositis. (22157423)
2013
7
Increased circulating soluble vascular adhesion protein-1 levels in systemic sclerosis: association with lower frequency and severity of interstitial lung disease. (23992266)
2013
8
Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. (22651223)
2012
9
Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis. (22213733)
2012
10
Drug induced interstitial lung disease. (22896776)
2012
11
Lung transplantation for interstitial lung disease. (22365254)
2012
12
An 18-year-old woman with Kabuki syndrome, immunoglobulin deficiency and granulomatous lymphocytic interstitial lung disease. (22372173)
2012
13
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. (22415303)
2012
14
The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis. (23257529)
2012
15
Interstitial lung disease induced or exacerbated by TNF-targeted therapies: analysis of 122 cases. (21277618)
2011
16
IV immunoglobulin might be considered as a first-line treatment of severe interstitial lung disease associated with polymyositis. (21813543)
2011
17
The impact of rheumatological evaluation in the management of patients with interstitial lung disease. (20685802)
2011
18
A clue to diagnosing connective tissue disease-associated interstitial lung disease. (21362663)
2011
19
Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. (21787189)
2011
20
Efficacy and safety of intravenous cyclophosphamide pulse therapy with oral prednisolone in the treatment of interstitial lung disease with systemic sclerosis: 4-year follow-up. (21240620)
2011
21
Depression and functional status are strongly associated with dyspnea in interstitial lung disease. (20688924)
2011
22
Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease. (21996293)
2011
23
Quantification of regional interstitial lung disease from CT-derived fractional tissue volume: a lung tissue research consortium study. (21596593)
2011
24
Developing disease activity and response criteria in connective tissue disease-related interstitial lung disease. (21724725)
2011
25
Efficacy of cyclophospamide in the treatment of interstitial lung disease associated with systemic sclerosis. (21458128)
2011
26
Reduced hypoxia risk in a systemic sclerosis patient with interstitial lung disease after long-term pulmonary rehabilitation. (22084615)
2011
27
Systemic sclerosis-related pulmonary hypertension associated with interstitial lung disease: impact of pulmonary arterial hypertension therapies. (21538327)
2011
28
Radiological evaluation of interstitial lung disease. (21597378)
2011
29
Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years? (21138882)
2010
30
Pulmonary rehabilitation for interstitial lung disease. (20605836)
2010
31
Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. (20404807)
2010
32
Interstitial lung disease and lung transplantation. (20354927)
2010
33
When and how should the patients with dermatomyositis be assessed for interstitial lung disease? (20367972)
2010
34
Expanding Our Understanding of Children's Interstitial Lung Disease. (22332027)
2010
35
Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. (20371530)
2010
36
Endothelin-1 and brain natriuretic peptide in the development of pulmonary hypertension in interstitial lung diseases]. (20481052)
2009
37
Esophageal involvement and interstitial lung disease in mixed connective tissue disease. (19201182)
2009
38
Exacerbation of interstitial lung disease during etanercept therapy: Two cases. (17977770)
2008
39
Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. (17174272)
2007
40
How to evaluate and treat children's interstitial lung disease. (16798580)
2006
41
Respiratory bronchiolitis-associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial pneumonia: a proposal. (16951670)
2006
42
Interstitial lung disease in patients with non-small-cell lung cancer treated with epidermal growth factor receptor inhibitors. (16720916)
2006
43
Surfactant dysfunction mutations in children's interstitial lung disease and beyond. (16216835)
2005
44
Polymyositis/dermatomyositis and interstitial lung disease: a new therapeutic approach with T-cell-specific immunosuppressants. (16227154)
2005
45
A role for MCP-1/CCR2 in interstitial lung disease in children. (16095529)
2005
46
Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease. (15653981)
2005
47
Respiratory bronchiolitis-associated interstitial lung disease. (16088575)
2003
48
Serum levels of surfactant proteins A and D are useful biomarkers for interstitial lung disease in patients with progressive systemic sclerosis. (10903251)
2000
49
Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. (9645759)
1998
50
Quantitative evaluation of the IL-1 beta and IL-1 receptor antagonist obtained from BALF macrophages in patients with interstitial lung diseases. (9186988)
1997

Genetic Variations for Interstitial Lung Disease

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Expression for genes affiliated with Interstitial Lung Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Interstitial Lung Disease

Search GEO for disease gene expression data for Interstitial Lung Disease.

Pathways for genes affiliated with Interstitial Lung Disease

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Sources:
51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Interstitial Lung Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.0CCL22, CCL18, SFTPC, SFTPD, SFTPB, S100A9
2dexamethasone44 49 28 1114.0CXCL9, CCL22, CCL18, SFTPC, SFTPD, SFTPB
3tarc4410.9CCL22, CCL18, CXCL5, CXCL9
4ccl344 2811.9CXCL9, CXCL5, CCL18, CCL22
5ccl444 2811.9CCL22, CCL18, CXCL5, CXCL9
6fibrinogen4410.9CCL22, SFTPC, SFTPB, S100A9, CHIT1
7infasurf4410.8SFTPB, SFTPC
8rantes4410.8CXCL5
9dppg4410.8SFTPC, SFTPB
10popg4410.8SFTPC, SFTPB
111,2-dipalmitoyl-sn-glycero-3-phosphocholine4410.8SFTPC, SFTPB
12ena 784410.8CXCL5, CXCL9
13curosurf4410.8SFTPC, SFTPB
14nitric oxide44 11 2412.7SFTPD, SFTPB, S100A9, CXCL5, CXCL9, TAC3
15endotoxin4410.7CXCL5, S100A9
16dopc4410.7SFTPC, SFTPB
17survanta4410.7SFTPC, SFTPB
18dppc4410.6SFTPB, SFTPC
19butanol4410.6SFTPC, SFTPB
20vegf4410.6CXCL9, CXCL5, SFTPB, SFTPC, CCL18
21p-opc4410.5SFTPC, SFTPB
22chloroform4410.4SFTPC, SFTPB
23larc4410.2CCL18, CCL22

GO Terms for genes affiliated with Interstitial Lung Disease

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Sources:
16Gene Ontology
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Cellular components related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SFTPD, S100A9, SCGB3A2, CD27, CXCL5, CXCL9
2extracellular spaceGO:00561510.4TAC3, CCL22, CCL18, SFTPC, SFTPD, SFTPB

Biological processes related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726710.7CXCL9, CXCL5, CD70, S100A9, CCL18, CCL22
2immune responseGO:00695510.7CCL22, CCL18, CHIT1, CD70, CXCL5, CXCL9
3chemotaxisGO:00693510.6CXCL9, CXCL5, CCL18, CCL22
4inflammatory responseGO:00695410.6CCL22, CCL18, S100A9, CXCL9, IL27
5response to bacteriumGO:00961710.5IL27, CHIT1
6respiratory gaseous exchangeGO:00758510.4SFTPB, SFTPD, SFTPC
7signal transductionGO:00716510.3CCL22, CCL18, S100A9, CD70, CXCL5, CXCL9

Molecular functions related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.5CXCL9, CXCL5, CCL18, CCL22

Products for genes affiliated with Interstitial Lung Disease

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Interstitial Lung Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet