ILD
MCID: INT066
MIFTS: 59

Interstitial Lung Disease (ILD) malady

Categories: Respiratory diseases

Aliases & Classifications for Interstitial Lung Disease

Aliases & Descriptions for Interstitial Lung Disease:

Name: Interstitial Lung Disease 12 14
Lung Diseases, Interstitial 42 69
Ild 12 14
Lung Diseases Interstitial 52
Interstitial Lung Diseases 41

Classifications:



External Ids:

Disease Ontology 12 DOID:3082
ICD10 33 J84.9
MeSH 42 D017563
SNOMED-CT 64 233703007 64667001
UMLS 69 C0206062

Summaries for Interstitial Lung Disease

MedlinePlus : 41 interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. the inflammation and scarring make it hard to get enough oxygen. the scarring is called pulmonary fibrosis. breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. specific types include black lung disease among coal miners, from inhaling coal dust farmer's lung, from inhaling farm dust asbestosis, from inhaling asbestos fibers siderosis, from inhaling iron from mines or welding fumes silicosis, from inhaling silica dust other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. some types of interstitial lung disease have no known cause. treatment depends on the type of exposure and the stage of the disease. it may involve medicines, oxygen therapy, or a lung transplant in severe cases.

MalaCards based summary : Interstitial Lung Disease, also known as lung diseases, interstitial, is related to rheumatoid arthritis and tuberculosis, and has symptoms including coughing, hemoptysis and snoring. An important gene associated with Interstitial Lung Disease is SFTPC (Surfactant Protein C), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bosentan and Cyclosporine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and b cells, and related phenotypes are Decreased viability with paclitaxel and homeostasis/metabolism

Wikipedia : 71 Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of lung diseases... more...

Related Diseases for Interstitial Lung Disease

Diseases related to Interstitial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 357)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 30.4 CCL2 CCL5 CXCL8 IL1A IL1B IL6
2 tuberculosis 29.9 CCL2 IL1B IL6 TNF
3 pulmonary eosinophilia 29.7 CCL2 CXCL8 IL1B IL6 TNF
4 histiocytosis 29.5 CXCL8 IL1A IL1B IL6 TNF
5 pulmonary tuberculosis 29.5 CCL5 CXCL8 IL6 MUC5B TNF
6 interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital 12.3
7 children's interstitial lung disease 12.3
8 respiratory bronchiolitis-interstitial lung disease syndrome 12.1
9 drug or radiation exposure-related interstitial lung disease 11.9
10 interstitial pneumonitis, desquamative, familial 11.6
11 autoimmune interstitial lung, joint, and kidney disease 11.5
12 antisynthetase syndrome 11.3
13 pulmonary fibrosis 11.3
14 dermatomyositis 11.3
15 surfactant dysfunction 11.2
16 surfactant metabolism dysfunction, pulmonary, 3 11.2
17 surfactant metabolism dysfunction, pulmonary, 2 11.2
18 extrinsic allergic alveolitis 11.1
19 surfactant metabolism dysfunction, pulmonary, 1 11.1
20 lung disease 11.0
21 pulmonary alveolar microlithiasis 11.0
22 sting-associated vasculopathy, infantile-onset 11.0
23 choreoathetosis, hypothyroidism, and neonatal respiratory distress 11.0
24 pulmonary surfactant metabolism dysfunction 10.9
25 abca3-related pulmonary surfactant metabolism dysfunction 10.9
26 sftpb-related pulmonary surfactant metabolism dysfunction 10.9
27 sftpc-related pulmonary surfactant metabolism dysfunction 10.9
28 anthracosis 10.8
29 mucoepithelial dysplasia, hereditary 10.8
30 bagassosis 10.8
31 interstitial lung and liver disease 10.8
32 niemann-pick disease, type c2 10.8
33 pneumoconiosis 10.8
34 connective tissue disease 10.5
35 arthritis 10.4
36 polymyositis 10.4
37 transverse myelitis 10.4 SFTPB SFTPD
38 ectodermal dysplasia with natal teeth, turnpenny type 10.4 SFTPB SFTPC
39 conjunctivochalasis 10.4 SFTPB SFTPC SFTPD
40 lung cancer 10.3
41 malignant oculomotor nerve tumor 10.3 CCL2 SFTPC TGFB1
42 schwannoma of ureter 10.3 CCL2 CXCL8 IL6
43 intussusception 10.3 IL1B TNF
44 thymic neuroendocrine carcinoma 10.3 CXCL8 IL6 TNF
45 oculomotor nerve paralysis 10.3 CXCL8 IL1B IL6
46 preaxial polydactyly of fingers 10.3 IL6 TGFB1 TNF
47 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 CCL5 IL6 TNF
48 common peroneal nerve lesion 10.3 CXCL8 IL1B IL6
49 lateral cystocele 10.3 CCL2 CXCL8 IL6
50 supratentorial primitive neuroectodermal tumor 10.3 CCL2 EDN1 IL6

Graphical network of the top 20 diseases related to Interstitial Lung Disease:



Diseases related to Interstitial Lung Disease

Symptoms & Phenotypes for Interstitial Lung Disease

UMLS symptoms related to Interstitial Lung Disease:


coughing, hemoptysis, snoring

GenomeRNAi Phenotypes related to Interstitial Lung Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 EGFR TGFB1
2 Decreased viability with paclitaxel GR00179-A-3 8.92 EGFR TGFB1

MGI Mouse Phenotypes related to Interstitial Lung Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 ABCA3 EDN1 EGFR IFIH1 IL1A IL1B
2 hematopoietic system MP:0005397 10.15 SFTPD TF TGFB1 CCL17 CCL5 EGFR
3 cardiovascular system MP:0005385 10.1 ABCA3 EDN1 EGFR IL1A IL1B IL6
4 immune system MP:0005387 10.07 CCL17 CCL2 CCL5 EGFR IFIH1 IL1A
5 mortality/aging MP:0010768 10 TGFB1 TNF ABCA3 EDN1 EGFR IFIH1
6 neoplasm MP:0002006 9.56 IL1B IL6 NKX2-1 SFTPC TGFB1 TNF
7 respiratory system MP:0005388 9.32 ABCA3 EGFR IL6 MUC5B NKX2-1 SFTPB

Drugs & Therapeutics for Interstitial Lung Disease

Drugs for Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 417)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 4,Phase 2,Phase 3 147536-97-8 104865
2
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
3
Daclizumab Approved, Investigational Phase 4,Phase 2 152923-56-3
4
Everolimus Approved Phase 4,Phase 3,Phase 2 159351-69-6 6442177
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
6
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2 53123-88-9 5284616 6436030 46835353
7
Calcium carbonate Approved Phase 4 471-34-1
8
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 50-18-0, 6055-19-2 2907
9
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
10
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 1 216503-57-0
11
Iloprost Approved, Investigational Phase 4,Phase 2,Phase 3 78919-13-8 6443959
12
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
13
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
14
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3 104987-11-3 445643 439492
15
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
16
Iron Approved Phase 4 7439-89-6 23925
17
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1 446-86-6 2265
18
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
21
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
22
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
23
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
24
Nintedanib Approved Phase 4,Phase 3,Phase 2 656247-17-5 56843413
25
Menthol Approved Phase 4 2216-51-5 16666
26
Gefitinib Approved, Investigational Phase 4,Phase 3 184475-35-2 123631
27
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
28
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
29
Morphine Approved, Investigational Phase 4 57-27-2 5288826
30
Ledipasvir Approved Phase 4 1256388-51-8 67505836
31
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
32
Trioxsalen Approved Phase 4 3902-71-4 5585
33
Nicotine Approved Phase 4,Phase 1,Phase 2 54-11-5 942 89594
34
Deferiprone Approved Phase 4 30652-11-0 2972
35
Acetylcholine Approved Phase 4 51-84-3 187
36 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
39
Pirfenidone Investigational Phase 4,Phase 3,Phase 2,Phase 1 53179-13-8 40632
40 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Endothelin Receptor Antagonists Phase 4,Phase 2,Phase 3
42 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2
43 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
44 Sildenafil Citrate Phase 4,Phase 2,Phase 3 171599-83-0
45 Vasodilator Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
48 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 654)
id Name Status NCT ID Phase
1 Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment Study Unknown status NCT00637065 Phase 4
2 Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis And Treatment With Sildenafil Unknown status NCT00625079 Phase 4
3 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Unknown status NCT02286063 Phase 4
4 Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan Unknown status NCT00625469 Phase 4
5 Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients Unknown status NCT01382368 Phase 4
6 Fibrosis in Renal Allografts Unknown status NCT00493194 Phase 4
7 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome Unknown status NCT02370550 Phase 4
8 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4
9 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
10 Pulmonary Rehabilitation in Interstitial Lung Diseases Completed NCT00882817 Phase 4
11 Iressa Case Control Study in Japan Completed NCT00252759 Phase 4
12 Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension Completed NCT00403650 Phase 4
13 Novartis Everolimus Transition Completed NCT02096107 Phase 4
14 Fractionated Versus Target-controlled Propofol Administration in Bronchoscopy Completed NCT02246023 Phase 4
15 A Study to Compare the Amount of Nintedanib and Pirfenidone in the Blood When Nintedanib and Pirfenidone Are Given Separately or in Combination Completed NCT02606877 Phase 4
16 Safety and Tolerability Study of Pirfenidone in Combination With Nintedanib in Participants With Idiopathic Pulmonary Fibrosis (IPF) Completed NCT02598193 Phase 4
17 Safety, Tolerability and PK of Nintedanib in Combination With Pirfenidone in IPF Completed NCT02579603 Phase 4
18 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
19 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4
20 Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication Completed NCT02246361 Phase 4
21 Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Breathing and Sleep Recruiting NCT02150616 Phase 4
22 Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Exercise Performance Recruiting NCT02143687 Phase 4
23 Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease Recruiting NCT02622022 Phase 4
24 Hepatitis C Virus(HCV) Heart and Lung Study Recruiting NCT02858180 Phase 4
25 Effect of Nintedanib on Biomarkers of Extracellular Matrix Turnover in Patients With Idiopathic Pulmonary Fibrosis and Limited Forced Vital Capacity Impairment Recruiting NCT02788474 Phase 4
26 Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Recruiting NCT02188017 Phase 4
27 Rituximab for the Otolaryngologic Manifestations of Granulomatosis With Polyangiitis Recruiting NCT02626845 Phase 4
28 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Recruiting NCT02115997 Phase 4
29 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4
30 Feasibility Study of Using Navigational Bronchoscopy to Perform PDT-Photofrin® in Unresectable Peripheral Lung Cancer Recruiting NCT02916745 Phase 4
31 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4
32 Importance of the Infusion Rate for the Plasma Expanding Effect of 5% Albumin in the Septic Patient Recruiting NCT03153306 Phase 4
33 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Active, not recruiting NCT01284127 Phase 4
34 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Active, not recruiting NCT02169219 Phase 4
35 Pirfenidone in Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis Not yet recruiting NCT02821689 Phase 4
36 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Not yet recruiting NCT03164473 Phase 4
37 Albumin in Cardiac Surgery Not yet recruiting NCT02560519 Phase 4
38 Study of Nicotine Patches in Patients With Sarcoidosis Suspended NCT00701207 Phase 4
39 68Ga-DOTA-NOC PET/CT in Patients With Idiopathic Pulmonary Fibrosis Terminated NCT01321996 Phase 4
40 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
41 Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP) Withdrawn NCT00636935 Phase 4
42 Treprostinil Therapy For Patients With Interstitial Lung Disease And Severe Pulmonary Arterial Hypertension Unknown status NCT00705133 Phase 3
43 Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection Unknown status NCT00841750 Phase 3
44 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3
45 Trial of Iloprost in Pulmonary Hypertension Secondary to Pulmonary Fibrosis Unknown status NCT00439543 Phase 2, Phase 3
46 Investigation in Myositis-associated Pneumonitis of Prednisolone And Concomitant Tacrolimus Unknown status NCT00504348 Phase 2, Phase 3
47 Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole Unknown status NCT01777737 Phase 3
48 T-Cell Depletion and Stem Cell Transplant for Immune Deficiencies and Histiocytic Disorders Unknown status NCT00176826 Phase 2, Phase 3
49 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3
50 WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides Unknown status NCT00349674 Phase 3

Search NIH Clinical Center for Interstitial Lung Disease

Cochrane evidence based reviews: lung diseases, interstitial

Genetic Tests for Interstitial Lung Disease

Anatomical Context for Interstitial Lung Disease

MalaCards organs/tissues related to Interstitial Lung Disease:

39
Lung, Testes, B Cells, Monocytes, T Cells, Skin, Neutrophil

Publications for Interstitial Lung Disease

Articles related to Interstitial Lung Disease:

(show top 50) (show all 943)
id Title Authors Year
1
Mortality and Respiratory Failure After Thoracoscopic Lung Biopsy for Interstitial Lung Disease. ( 28527960 )
2017
2
Can we effectively use radiographic imaging and clinical parameters for making an earlier diagnosis of granulomatous interstitial lung disease in patients with common variable immunodeficiency? ( 28477784 )
2017
3
Interstitial Lung Disease Induced by Pazopanib Treatment. ( 28050004 )
2017
4
Predictors of granulomatous lymphocytic interstitial lung disease in common variable immunodeficiency. ( 28254202 )
2017
5
Are risk predicting models useful for estimating survival of patients with rheumatoid arthritis-associated interstitial lung disease? ( 28086844 )
2017
6
Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population. ( 28470010 )
2017
7
Autoantibody to scaffold attachment factor B (SAFB): A novel connective tissue disease-related autoantibody associated with interstitial lung disease. ( 27682649 )
2017
8
Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy. ( 27995057 )
2017
9
Concomitant lung cancer and interstitial lung disease: A challenge in clinical practice. ( 28063797 )
2017
10
British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders. ( 28351785 )
2017
11
Integrative Cardiopulmonary Ultrasound for Interstitial Lung Disease Assessment: Correlation between Lung Ultrasound Performance and Cardiac Involvement. ( 28073593 )
2017
12
FDG PET-CT imaging of therapeutic response in granulomatous lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). ( 27896807 )
2017
13
Interstitial lung disease in systemic sclerosis: current and future treatment. ( 28063071 )
2017
14
Hypomyopathic dermatomyositis associated with interstitial lung disease and good response to mycophenolate mofetil: case-based review. ( 28488124 )
2017
15
The correlation between miR-200c and the severity of interstitial lung disease associated with different connective tissue diseases. ( 27309544 )
2017
16
Association of anti-aminoacyl-transfer RNA synthetase antibody and anti-melanoma differentiation-associated gene 5 antibody with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease. ( 28012490 )
2017
17
X-linked Inhibitor of Apoptosis Complicated by Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) and Granulomatous Hepatitis. ( 27492372 )
2016
18
Evaluation of computer-based computer tomography stratification against outcome models in connective tissue disease-related interstitial lung disease: a patient outcome study. ( 27876024 )
2016
19
Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns. ( 27979657 )
2016
20
A case of antisynthetase syndrome with elevated serum CA19-9 associated with interstitial lung disease. ( 27777184 )
2016
21
Clinical analysis and outcome of interstitial lung disease complicated with juvenile dermatomyositis and juvenile polymyositis. ( 27588444 )
2016
22
Rituximab therapy in primary SjAPgren's syndrome with interstitial lung disease: a retrospective cohort study. ( 27607895 )
2016
23
Prognostic Role of Exhaled Breath Condensate pH and Fraction Exhaled Nitric Oxide in Systemic Sclerosis Related Interstitial Lung Disease. ( 28038794 )
2016
24
Interstitial Lung Disease Caused by STING-associated Vasculopathy with Onset in Infancy. ( 27585386 )
2016
25
Anti-EJ antibody positive interstitial lung disease with skin changes at the fingertips. ( 27212602 )
2016
26
Rituximab in autoimmune connective tissue disease-associated interstitial lung disease. ( 27060110 )
2016
27
Two cases of autoimmune and secondary pulmonary alveolar proteinosis during immunosuppressive therapy in dermatomyositis with interstitial lung disease. ( 26872621 )
2016
28
Acquired acanthosis nigricans with tripe palms in a patient with interstitial lung disease. ( 27051830 )
2016
29
Management of granulomatous lymphocytic interstitial lung disease in a patient with common variable immune deficiency. ( 27335365 )
2016
30
Pirfenidone in patients with rapidly progressive interstitial lung disease associated with clinically amyopathic dermatomyositis. ( 27615411 )
2016
31
Serum Procalcitonin for Differential Diagnosis of Acute Exacerbation and Bacterial Pneumonia in Patients With Interstitial Lung Disease. ( 27140709 )
2016
32
Multidisciplinary discussions and interstitial lung disease diagnosis: how useful is a meeting of the minds? ( 27180020 )
2016
33
Benefit of adjunctive tacrolimus in connective tissue disease-interstitial lung disease. ( 26762710 )
2016
34
Rheumatoid arthritis-associated autoantibodies and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis. ( 27609750 )
2016
35
Antisynthetase syndrome: An under-recognized cause of interstitial lung disease. ( 26933302 )
2016
36
Extracorporeal membrane oxygenation for interstitial lung disease: what is on the other side of the bridge? ( 27619972 )
2016
37
Fragmented gelsolins are increased in rheumatoid arthritis-associated interstitial lung disease with usual interstitial pneumonia pattern. ( 26666486 )
2016
38
Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis-related interstitial lung disease. ( 28038680 )
2016
39
Management of interstitial lung disease associated with connective tissue disease. ( 26912511 )
2016
40
Interstitial lung disease in infancy: A general approach. ( 27145498 )
2016
41
Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008. ( 27660509 )
2016
42
Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease. ( 27888997 )
2016
43
Tools to explore ABCA3 mutations causing interstitial lung disease. ( 27177387 )
2016
44
Interstitial lung disease associated with amrubicin chemotherapy in patients with lung cancer: a single institutional study. ( 27162319 )
2016
45
A novel surfactant protein C L55F mutation associated with interstitial lung disease alters subcellular localization of proSP-C in A549 cells. ( 26375473 )
2016
46
Autoantibodies Are Already Found in Connective Tissue Disease-Associated Interstitial Lung Disease. ( 27613986 )
2016
47
Tumour markers in rheumatoid arthritis-associated interstitial lung disease. ( 27213221 )
2016
48
Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease. ( 27185993 )
2016
49
High incidence of interstitial lung disease following practical use of osimertinib in patients who had undergone immediate prior nivolumab therapy. ( 27993813 )
2016
50
Pemphigus vulgaris-associated interstitial lung disease. ( 26969825 )
2016

Variations for Interstitial Lung Disease

Expression for Interstitial Lung Disease

Search GEO for disease gene expression data for Interstitial Lung Disease.

Pathways for Interstitial Lung Disease

Pathways related to Interstitial Lung Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CCL2 CCL5 CXCL8 EGFR IFIH1 IL1A
2
Show member pathways
13.93 CCL17 CCL2 CCL5 CXCL8 EGFR IL1A
3
Show member pathways
13.87 ABCA3 CCL2 CXCL8 IFIH1 MUC1 MUC5B
4
Show member pathways
13.73 CCL17 CCL2 CCL5 CXCL8 EDN1 EGFR
5
Show member pathways
13.61 CCL17 CCL2 CCL5 CXCL8 EGFR IL1A
6
Show member pathways
13.47 CCL17 CCL2 CCL5 CXCL8 EGFR IL1A
7
Show member pathways
13.43 CCL2 CCL5 CXCL8 EGFR IL1A IL1B
8
Show member pathways
13.35 CCL17 CCL2 CCL5 CXCL8 EGFR IL1A
9
Show member pathways
13.01 CCL2 CCL5 CXCL8 EDN1 EGFR IL1A
10
Show member pathways
12.95 CCL2 CCL5 CXCL8 IFIH1 IL1B IL6
11
Show member pathways
12.93 CXCL8 IL1A IL1B IL6 TGFB1 TNF
12
Show member pathways
12.84 CCL2 CCL5 CXCL8 IFIH1 IL1A IL1B
13
Show member pathways
12.81 CCL5 CXCL8 IFIH1 IL1B IL6 TNF
14
Show member pathways
12.78 EGFR IL1A IL1B IL6 TGFB1 TNF
15 12.77 EGFR IL1A IL1B TGFB1 TNF
16
Show member pathways
12.66 IL1A IL1B IL6 TGFB1 TNF
17
Show member pathways
12.66 CCL2 EGFR IL1B IL6 TNF
18 12.62 CCL2 CCL5 IFIH1 IL1B TNF
19
Show member pathways
12.51 IL1A IL1B IL6 TGFB1 TNF
20
Show member pathways
12.42 CCL2 CCL5 IL1B IL6 TNF
21
Show member pathways
12.39 CCL17 CCL2 CXCL8 IL1B IL6 MUC5B
22
Show member pathways
12.35 CXCL8 IL1A IL1B IL6 TNF
23
Show member pathways
12.32 CXCL8 IL1A IL6 TNF
24 12.32 IL1A IL1B IL6 TGFB1 TNF
25
Show member pathways
12.31 IL1A IL1B TGFB1 TNF
26
Show member pathways
12.26 CXCL8 IL1B IL6 MUC1 SFTPD TNF
27 12.25 EGFR IL6 TGFB1 TNF
28
Show member pathways
12.25 CXCL8 IL1A IL1B IL6 TNF
29 12.25 CXCL8 IL1A IL1B IL6 TF TNF
30 12.19 CCL2 EDN1 IL1A IL1B TNF
31 12.13 IL1A IL1B TGFB1 TNF
32
Show member pathways
12.11 CCL17 CCL2 CCL5 CXCL8
33 12.05 CCL2 CXCL8 EGFR IL1A IL1B IL6
34
Show member pathways
12.03 IL1B IL6 TGFB1 TNF
35 12.03 CXCL8 IL1A IL1B IL6 TGFB1
36 12.01 CCL2 CCL5 EDN1 IL1B IL6 TNF
37 12 EDN1 EGFR IL6 TF
38 11.98 IL1A IL1B IL6 TNF
39 11.98 CCL2 CXCL8 IL1A IL1B IL6 MUC1
40 11.97 CXCL8 IL1B IL6 TGFB1 TNF
41 11.92 CXCL8 IL1A IL1B IL6
42 11.85 IL1B IL6 TGFB1 TNF
43 11.85 CXCL8 IL1A IL1B IL6 TNF
44 11.77 IL6 TGFB1 TNF
45 11.75 CCL2 CXCL8 EDN1 IL1A IL1B IL6
46 11.73 CXCL8 EGFR IL6
47
Show member pathways
11.73 CXCL8 IL1A IL1B IL6 TNF
48 11.69 CXCL8 IL1B IL6 TNF
49 11.62 CXCL8 IL6 TGFB1
50 11.62 EGFR IL6 TNF

GO Terms for Interstitial Lung Disease

Cellular components related to Interstitial Lung Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 CCL17 CCL2 CCL5 CXCL8 EDN1 EGFR
2 extracellular space GO:0005615 9.58 ABCA3 CCL17 CCL2 CCL5 CXCL8 EDN1
3 endocytic vesicle GO:0030139 9.56 CCL2 EGFR SFTPD TF
4 clathrin-coated endocytic vesicle GO:0045334 9.5 SFTPB SFTPC SFTPD
5 multivesicular body lumen GO:0097486 9.4 SFTPB SFTPC
6 alveolar lamellar body GO:0097208 9.37 ABCA3 SFTPB
7 lamellar body GO:0042599 9.33 SFTPB SFTPC SFTPD

Biological processes related to Interstitial Lung Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.99 IL1B IL6 TGFB1 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.98 CCL2 CXCL8 IL6 TNF
3 animal organ morphogenesis GO:0009887 9.97 CCL2 NKX2-1 SFTPB TNF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.96 EDN1 IL1B IL6 TNF
5 response to wounding GO:0009611 9.93 CCL2 IL6 TGFB1
6 cellular response to mechanical stimulus GO:0071260 9.93 EGFR IL1B TGFB1
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.93 IL6 TGFB1 TNF
8 positive regulation of protein kinase B signaling GO:0051897 9.93 EGFR IL6 TGFB1 TNF
9 regulation of insulin secretion GO:0050796 9.92 CCL5 IL1B TNF
10 positive regulation of T cell proliferation GO:0042102 9.92 CCL5 IL1B IL6
11 response to glucocorticoid GO:0051384 9.92 ABCA3 CCL2 IL6 TNF
12 chemokine-mediated signaling pathway GO:0070098 9.92 CCL17 CCL2 CCL5 CXCL8
13 cellular response to drug GO:0035690 9.91 CCL2 EDN1 EGFR IL1B
14 cellular response to tumor necrosis factor GO:0071356 9.91 CCL17 CCL2 CCL5 CXCL8 EDN1 IL6
15 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL17 CCL2 CCL5 EGFR IL6 TGFB1
16 humoral immune response GO:0006959 9.9 CCL2 IL6 TNF
17 cell growth GO:0016049 9.9 EDN1 IL6 TGFB1
18 positive regulation of cell adhesion GO:0045785 9.9 CCL2 CCL5 TNF
19 positive regulation of epithelial cell proliferation GO:0050679 9.9 CCL5 EGFR IL6 TGFB1
20 positive regulation of cell division GO:0051781 9.89 IL1A IL1B TGFB1
21 cellular response to interferon-gamma GO:0071346 9.89 CCL17 CCL2 CCL5 EDN1
22 cellular response to organic cyclic compound GO:0071407 9.89 CCL2 CCL5 IL1B TGFB1 TNF
23 negative regulation of fat cell differentiation GO:0045599 9.88 IL6 TGFB1 TNF
24 positive regulation of MAP kinase activity GO:0043406 9.88 EDN1 EGFR TGFB1 TNF
25 cellular response to estradiol stimulus GO:0071392 9.86 CCL2 EGFR IL6
26 response to amino acid GO:0043200 9.86 CCL2 EDN1 IL6
27 positive regulation of interleukin-6 production GO:0032755 9.86 IL1A IL1B IL6 TNF
28 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 IL1A IL1B TNF
29 monocyte chemotaxis GO:0002548 9.85 CCL17 CCL2 CCL5 IL6
30 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 CCL5 EDN1 EGFR IL6 TNF
31 cellular response to fibroblast growth factor stimulus GO:0044344 9.84 CCL2 CCL5 CXCL8
32 respiratory gaseous exchange GO:0007585 9.84 EDN1 SFTPB SFTPC SFTPD
33 positive regulation of phagocytosis GO:0050766 9.83 IL1B SFTPD TNF
34 negative regulation of mitotic cell cycle GO:0045930 9.83 EGFR TGFB1 TNF
35 positive regulation of vascular endothelial growth factor production GO:0010575 9.82 IL1A IL1B TGFB1
36 positive regulation of mitotic nuclear division GO:0045840 9.82 EDN1 IL1A IL1B
37 negative regulation of myoblast differentiation GO:0045662 9.81 CCL17 TGFB1 TNF
38 cellular response to dexamethasone stimulus GO:0071549 9.81 CCL2 EGFR IL6 TGFB1
39 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 EDN1 EGFR IL1B IL6 TNF
40 negative regulation of hormone secretion GO:0046888 9.76 EDN1 IL6
41 macrophage chemotaxis GO:0048246 9.76 CCL2 CCL5 SFTPD
42 maternal process involved in parturition GO:0060137 9.75 CCL2 EDN1
43 salivary gland morphogenesis GO:0007435 9.75 EGFR TGFB1
44 positive regulation of superoxide anion generation GO:0032930 9.75 EGFR TGFB1
45 positive regulation of chemokine biosynthetic process GO:0045080 9.75 IL1B TNF
46 negative regulation of lipid storage GO:0010888 9.74 IL6 TNF
47 neutrophil activation GO:0042119 9.74 CCL5 CXCL8
48 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.74 EGFR TGFB1
49 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.74 IL1A IL1B
50 ectopic germ cell programmed cell death GO:0035234 9.74 IL1A IL1B

Molecular functions related to Interstitial Lung Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.65 CCL17 CCL2 EDN1 EGFR IL6
2 cytokine activity GO:0005125 9.32 CCL17 CCL2 CCL5 CXCL8 EDN1 IL1A
3 chemokine activity GO:0008009 9.26 CCL17 CCL2 CCL5 CXCL8
4 CCR4 chemokine receptor binding GO:0031729 9.16 CCL17 CCL5

Sources for Interstitial Lung Disease

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