ILD
MCID: INT066
MIFTS: 46

Interstitial Lung Disease (ILD) malady

Summaries for Interstitial Lung Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. the inflammation and scarring make it hard to get enough oxygen. the scarring is called pulmonary fibrosis. breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. specific types include black lung disease among coal miners, from inhaling coal dust farmer's lung, from inhaling farm dust asbestosis, from inhaling asbestos fibers siderosis, from inhaling iron from mines or welding fumes silicosis, from inhaling silica dust other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. some types of interstitial lung disease have no known cause. treatment depends on the type of exposure and the stage of the disease. it may involve medicines, oxygen therapy, or a lung transplant in severe cases.

MalaCards: Interstitial Lung Disease, also known as lung diseases, interstitial, is related to arthritis and polymyositis. An important gene associated with Interstitial Lung Disease is SFTPC (surfactant protein C), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds calcium and dexamethasone have been mentioned in the context of this disorder. Related mouse phenotype immune system.

Wikipedia:64 Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD), refers to a... more...

Aliases & Classifications for Interstitial Lung Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 35MeSH, 57SNOMED-CT
See all sources

Aliases & Descriptions:

interstitial lung disease 8 10
lung diseases, interstitial 61
lung diseases interstitial 45
interstitial lung diseases 34
ild 8


External Ids:

Disease Ontology8 DOID:3082
SNOMED-CT57 233703007, 64667001
MeSH35 D017563

Related Diseases for Interstitial Lung Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Interstitial Lung Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.2S100A9, CXCL5, CXCL9
2polymyositis31.2S100A9, SFTPD
3idiopathic pulmonary fibrosis30.7CCL22, SFTPC, SFTPD, SFTPB, CXCL5, CXCL9
4cystic fibrosis30.3S100A9, SFTPB, SFTPD, SFTPC, CCL22
5pulmonary disease, chronic obstructive30.3SFTPD
6asthma30.1CCL22, SFTPC, SFTPD, SFTPB, SCGB3A2, CHIT1
7pulmonary sarcoidosis30.1CXCL9, CXCL5, SFTPD
8uveitis30.1CXCL9
9tuberculosis30.1CXCL9, SFTPD
10rheumatoid lung disease10.8
11amyopathic dermatomyositis10.7
12bronchiolitis10.7
13respiratory bronchiolitis - interstitial lung disease10.7
14antisynthetase syndrome10.6
15children's interstitial lung disease10.5
16desquamative interstitial pneumonia10.4
17common variable immunodeficiency10.4
18pulmonary systemic sclerosis10.4
19usual interstitial pneumonia10.4
20interstitial emphysema10.4
21mixed connective tissue disease10.4
22adenocarcinoma10.4
23vascular disease10.4
24colorectal cancer10.4
25pulmonary function10.4
26interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.4
27nonspecific interstitial pneumonia10.3
28diffuse scleroderma10.3
29erdheim-chester disease10.3
30adult dermatomyositis10.3
31hermansky-pudlak syndrome10.3
32brain disease10.3
33idiopathic myopathy10.3
34dyskeratosis congenita10.2
35respiratory bronchiolitis-associated interstitial lung disease10.2
36sjogren's syndrome10.2
37systemic lupus erythematosus10.2
38lung lymphoma10.2
39protein s deficiency10.2
40gastroesophageal reflux disease10.2
41n syndrome10.2
42systemic scleroderma10.2
43vasculitis10.2
44lysinuric protein intolerance10.2
45spontaneous pneumothorax10.2
46surfactant dysfunction10.2
47sleep apnea10.2
48primary interstitial lung disease specific to childhood due to pulmonary surfactant protein anomalies10.2
49moyamoya disease10.1
50crohn's disease10.1

Graphical network of the top 20 diseases related to Interstitial Lung Disease:



Diseases related to interstitial lung disease

Clinical Features for Interstitial Lung Disease

Drugs & Therapeutics for Interstitial Lung Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Interstitial Lung Disease

Drug clinical trials:

Search ClinicalTrials for Interstitial Lung Disease

Search NIH Clinical Center for Interstitial Lung Disease

Search CenterWatch for Interstitial Lung Disease

Genetic Tests for Interstitial Lung Disease

Anatomical Context for Interstitial Lung Disease

Animal Models for Interstitial Lung Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Interstitial Lung Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6IL27, CXCL9, CD27, CD70, CHIT1, ITGA3

Publications for Interstitial Lung Disease

Sources:
51PubMed
See all sources

Articles related to Interstitial Lung Disease:

(show top 50)    (show all 730)
idTitleAuthorsYear
1
Caution for interstitial lung disease as a cause of CA 15-3 rise in advanced breast cancer patients treated with everolimus. (24415627)
2014
2
Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease. (23716070)
2013
3
Interstitial Lung Disease Probably Caused by Imipramine. (22960847)
2013
4
Long-term efficacy and safety of maintenance therapy with azathioprine or cyclosporine for interstitial lung disease with diffuse cutaneous scleroderma. (23910623)
2013
5
Surgical lung biopsy for the diagnosis of interstitial lung disease: a review of the literature and recommendations for optimizing safety and efficacy. (24003530)
2013
6
Common variable immunodeficiency-associated granulomatous and interstitial lung disease. (23880700)
2013
7
Interstitial lung disease in two brothers with novel compound heterozygous ABCA3 mutations. (23443156)
2013
8
Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis? (23588945)
2013
9
Impaired chronotropic response to 6-minA walk test and reduced survival in interstitial lung disease. (23669412)
2013
10
Nested case control study of proteomic biomarkers for interstitial lung disease in Japanese patients with non-small-cell lung cancer treated with erlotinib: a multicenter phase IV study (JO21661). (23490546)
2013
11
Type B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease. (23346003)
2013
12
A case of fatal cetuximab-induced interstitial lung disease during the first weeks of treatment. (24114566)
2013
13
Leflunomide-induced interstitial lung disease (a systematic review). (24284289)
2013
14
Primary Sjogren's syndrome 1976-2005 and associated interstitial lung disease: a population-based study of incidence and mortality. (24282246)
2013
15
Interstitial lung disease in systemic sclerosis: pathophysiology, current and new advances in therapy. (22506881)
2012
16
Diffuse and interstitial lung disease and childhood rheumatologic disorders. (22820514)
2012
17
Aggregate risk score for predicting mortality after surgical biopsy for interstitial lung disease. (22596096)
2012
18
Depression is a common and chronic comorbidity in patients with interstitial lung disease. (22221976)
2012
19
Elevated nocturnal desaturation index predicts mortality in interstitial lung disease. (23311122)
2012
20
Interstitial lung disease in a child heterozygous for the 1549C-->GAA (121ins2) mutation of surfactant protein B. (21965505)
2011
21
Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders? (21273390)
2011
22
Effect of mycophenolate sodium in scleroderma-related interstitial lung disease. (21881859)
2011
23
Biological treatments and connective tissue disease associated interstitial lung disease. (21597375)
2011
24
Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease. (21312187)
2011
25
Proteomic biomarkers for acute interstitial lung disease in gefitinib-treated Japanese lung cancer patients. (21799770)
2011
26
Assessment of multichannel lung sounds parameterization for two-class classification in interstitial lung disease patients. (21571265)
2011
27
Interstitial lung disease - An approach to diagnosis and management. (20369109)
2010
28
Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. (20069430)
2010
29
NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in "Brain-Lung-Thyroid Syndrome". (20020530)
2010
30
Treatment of pulmonary hypertension in patients with connective tissue disease and interstitial lung disease. (21165350)
2010
31
Retrospective study of interstitial lung disease in a tertiary care centre in India. (21302597)
2010
32
Bibliography. Interstitial lung disease. Current world literature. (20698053)
2010
33
The role of high-resolution computed tomography in the work-up of interstitial lung disease. (20644479)
2010
34
Serum TARC/CCL17 levels are increased in dermatomyositis associated with interstitial lung disease. (20800454)
2010
35
Bilateral pleural effusion and interstitial lung disease as unusual manifestations of Kikuchi-Fujimoto disease: case report and literature review. (21054856)
2010
36
Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort. (20813056)
2010
37
Proliferative activity in fibrosing lung diseases: a comparative study of Ki-67 immunoreactivity in diffuse alveolar damage, bronchiolitis obliterans-organizing pneumonia, and usual interstitial pneumonia. (19368952)
2009
38
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases. (18327397)
2008
39
Respiratory bronchiolitis-associated interstitial lung disease in a nonsmoker: radiologic and pathologic findings. (17449735)
2007
40
Interferon gamma (IFN-gamma) level in broncholaveolar lavage (BAL) fluid is positively correlated with CD4/CD8 ratio in selected interstitial lung diseases]. (18051824)
2007
41
Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases. (17696954)
2007
42
An unusual presentation of amyopathic dermatomyositis associated with fatal interstitial lung disease. (16415402)
2006
43
Metastatic choriocarcinoma successfully treated with paclitaxel and carboplatin after interstitial lung disease induced by EMA-CO. (16580712)
2006
44
Familial interstitial lung disease in two young Korean sisters. (16361824)
2005
45
Interstitial lung disease in patients with polymyositis, dermatomyositis and amyopathic dermatomyositis. (15972351)
2005
46
Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. (15297967)
2004
47
Cytokine profile of bronchoalveolar lavage in systemic sclerosis with interstitial lung disease: comparison with usual interstitial pneumonia. (15194596)
2004
48
Erdheim-Chester disease: clinical, radiologic, and histopathologic findings in five patients with interstitial lung disease. (9888700)
1999
49
Secretion of stem cell factor by alveolar fibroblasts in interstitial lung diseases. (10369131)
1999
50
Expression of RANTES by bronchoalveolar lavage cells in nonsmoking patients with interstitial lung diseases. (9533940)
1998

Genetic Variations for Interstitial Lung Disease

Expression for genes affiliated with Interstitial Lung Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Interstitial Lung Disease

Search GEO for disease gene expression data for Interstitial Lung Disease.

Pathways for genes affiliated with Interstitial Lung Disease

Sources:
52QIAGEN, 30KEGG, 54Reactome
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Compounds for genes affiliated with Interstitial Lung Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.0CCL22, CCL18, SFTPC, SFTPD, SFTPB, S100A9
2dexamethasone45 50 29 1114.0CXCL9, CCL22, CCL18, SFTPC, SFTPD, SFTPB
3tarc4510.9CCL22, CCL18, CXCL5, CXCL9
4ccl345 2911.9CXCL9, CXCL5, CCL18, CCL22
5ccl445 2911.9CCL22, CCL18, CXCL5, CXCL9
6fibrinogen4510.9CCL22, SFTPC, SFTPB, S100A9, CHIT1
7infasurf4510.8SFTPB, SFTPC
8rantes4510.8CXCL5
9dppg4510.8SFTPC, SFTPB
10popg4510.8SFTPC, SFTPB
111,2-dipalmitoyl-sn-glycero-3-phosphocholine4510.8SFTPC, SFTPB
12ena 784510.8CXCL5, CXCL9
13curosurf4510.8SFTPC, SFTPB
14nitric oxide45 11 2412.7SFTPD, SFTPB, S100A9, CXCL5, CXCL9, TAC3
15endotoxin4510.7CXCL5, S100A9
16dopc4510.7SFTPC, SFTPB
17survanta4510.7SFTPC, SFTPB
18dppc4510.6SFTPB, SFTPC
19butanol4510.6SFTPC, SFTPB
20vegf4510.6CXCL9, CXCL5, SFTPB, SFTPC, CCL18
21p-opc4510.5SFTPC, SFTPB
22chloroform4510.4SFTPC, SFTPB
23larc4510.2CCL18, CCL22

GO Terms for genes affiliated with Interstitial Lung Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SFTPD, S100A9, SCGB3A2, CD27, CXCL5, CXCL9
2extracellular spaceGO:00561510.4TAC3, CCL22, CCL18, SFTPC, SFTPD, SFTPB

Biological processes related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726710.7CXCL9, CXCL5, CD70, S100A9, CCL18, CCL22
2immune responseGO:00695510.7CCL22, CCL18, CHIT1, CD70, CXCL5, CXCL9
3chemotaxisGO:00693510.6CXCL9, CXCL5, CCL18, CCL22
4inflammatory responseGO:00695410.6CCL22, CCL18, S100A9, CXCL9, IL27
5response to bacteriumGO:00961710.5IL27, CHIT1
6respiratory gaseous exchangeGO:00758510.4SFTPB, SFTPD, SFTPC
7signal transductionGO:00716510.3CCL22, CCL18, S100A9, CD70, CXCL5, CXCL9

Molecular functions related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.5CXCL9, CXCL5, CCL18, CCL22

Products for genes affiliated with Interstitial Lung Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Interstitial Lung Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet