ILD
MCID: INT066
MIFTS: 53

Interstitial Lung Disease (ILD) malady

Respiratory diseases category

Summaries for Interstitial Lung Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. the inflammation and scarring make it hard to get enough oxygen. the scarring is called pulmonary fibrosis. breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. specific types include black lung disease among coal miners, from inhaling coal dust farmer's lung, from inhaling farm dust asbestosis, from inhaling asbestos fibers siderosis, from inhaling iron from mines or welding fumes silicosis, from inhaling silica dust other causes include autoimmune diseases or occupational exposures to molds, gases, or fumes. some types of interstitial lung disease have no known cause. treatment depends on the type of exposure and the stage of the disease. it may involve medicines, oxygen therapy, or a lung transplant in severe cases.

MalaCards: Interstitial Lung Disease, also known as lung diseases, interstitial, is related to rheumatoid arthritis and arthritis. An important gene associated with Interstitial Lung Disease is SFTPC (surfactant protein C), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds calcium and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related mouse phenotype immune system.

Wikipedia:63 Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD), refers to a... more...

Aliases & Classifications for Interstitial Lung Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

interstitial lung disease 8 10
lung diseases, interstitial 60
lung diseases interstitial 44
interstitial lung diseases 33
ild 8


External Ids:

Disease Ontology8 DOID:3082
SNOMED-CT56 233703007, 64667001
MeSH34 D017563

Related Diseases for Interstitial Lung Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Interstitial Lung Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis31.2CCL18, SFTPD, S100A9, CD70, CD27, CXCL5
2arthritis31.2S100A9, CXCL5, CXCL9
3pneumonia31.0CCL22, CCL18, SFTPC, SFTPD, SFTPB, CXCL5
4pulmonary fibrosis30.9SFTPD, SFTPC, CCL18, CCL22
5idiopathic pulmonary fibrosis30.7CCL22, SFTPC, SFTPD, SFTPB, CXCL5, CXCL9
6melanoma30.4ITGA3, CD70, CD27, CXCL5, CXCL9
7skin disease30.4CXCL9
8respiratory failure30.4SFTPC, SFTPD, SFTPB
9lupus erythematosus30.4CD70
10sarcoidosis30.2CCL18, SFTPD, S100A9, CHIT1, CD27, CXCL5
11cystic fibrosis30.2S100A9, SFTPB, SFTPD, SFTPC, CCL22
12extrinsic allergic alveolitis30.2CXCL5, SFTPD
13asthma30.0CCL22, SFTPC, SFTPD, SFTPB, SCGB3A2, CHIT1
14influenza30.0CCL18, SFTPD, CD27, CXCL9
15pulmonary sarcoidosis30.0CXCL9, CXCL5, SFTPD
16multiple sclerosis30.0CHIT1, CD27, CXCL9
17uveitis30.0CXCL9
18tuberculosis30.0CXCL9, SFTPD
19non-small cell lung carcinoma30.0SFTPB, SFTPD, SFTPC
20dermatomyositis11.0
21rheumatoid lung disease10.8
22connective tissue disease10.8
23lung cancer10.8
24scleroderma10.7
25hypertension10.7
26bronchiolitis10.7
27respiratory bronchiolitis-associated interstitial lung disease10.7
28myopathy10.4
29myositis10.4
30desquamative interstitial pneumonia10.4
31common variable immunodeficiency10.4
32pulmonary systemic sclerosis10.4
33interstitial emphysema10.3
34mixed connective tissue disease10.3
35adenocarcinoma10.3
36esophageal disease10.3
37esophagitis10.3
38idiopathic interstitial pneumonia10.3
39lung adenocarcinoma10.3
40obstructive lung disease10.3
41pneumothorax10.3
42vascular disease10.3
43colorectal cancer10.3
44children's interstitial lung disease10.3
45interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital10.3
46nonspecific interstitial pneumonia10.3
47diffuse scleroderma10.3
48erdheim-chester disease10.3
49adult dermatomyositis10.3
50hermansky-pudlak syndrome10.3

Graphical network of the top 20 diseases related to Interstitial Lung Disease:



Diseases related to interstitial lung disease

Clinical Features for Interstitial Lung Disease

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Drugs & Therapeutics for Interstitial Lung Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Interstitial Lung Disease

Drug clinical trials:

Search ClinicalTrials for Interstitial Lung Disease

Search NIH Clinical Center for Interstitial Lung Disease

Search CenterWatch for Interstitial Lung Disease

Genetic Tests for Interstitial Lung Disease

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Anatomical Context for Interstitial Lung Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Interstitial Lung Disease:

32
Lung, Testes, Monocytes, Skin, Endothelial, Brain, T cells, B cells, Thyroid, Heart, Breast, Lymph node, Bone, Smooth muscle

Animal Models for Interstitial Lung Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Interstitial Lung Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6IL27, CXCL9, CD27, CD70, CHIT1, ITGA3

Publications for Interstitial Lung Disease

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Sources:
50PubMed
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Articles related to Interstitial Lung Disease:

(show top 50)    (show all 729)
idTitleAuthorsYear
1
Riociguat for interstitial lung disease and pulmonary hypertension: a pilot trial. (22936711)
2013
2
Predictors of mortality in rheumatoid arthritis-related interstitial lung disease. (24372981)
2013
3
Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease. (23915349)
2013
4
An approach to the development of interstitial lung disease in dermatomyositis: a study of 230 cases in China. (23569020)
2013
5
Autoreactive bronchus-associated lymphoid tissue in interstitial lung disease: friend or foe? (23544886)
2013
6
An unusual case of cystic interstitial lung disease. (23562001)
2013
7
Uniportal VATS for pneumothorax and interstitial lung disease. (24040528)
2013
8
Mycophenolate versus cyclophosphamide for progressive interstitial lung disease associated with systemic sclerosis: a 2-year case control study. (23925736)
2013
9
Influenza vaccine-induced interstitial lung disease. (23370803)
2013
10
Fibrosing interstitial pneumonia predicts survival in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). (23791462)
2013
11
Interstitial lung disease in a child with antisynthetase syndrome. (23652349)
2013
12
Effects of inpatient pulmonary rehabilitation in patients with interstitial lung disease. (23100507)
2013
13
Pulmonary rehabilitation and interstitial lung disease: aiding the referral decision. (23595005)
2013
14
The clinical significance of HRCT in evaluation of patients with rheumatoid arthritis-associated interstitial lung disease: a report from China. (21132550)
2012
15
Interstitial lung disease associated with azacitidine use: a case report. (20634671)
2012
16
Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy. (22282550)
2012
17
Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia. (21762563)
2012
18
Patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma. (22438405)
2012
19
Disappearance of anti-MDA-5 autoantibodies in clinically amyopathic DM/interstitial lung disease during disease remission. (22210662)
2012
20
A systematic review of validated methods for identifying pulmonary fibrosis and interstitial lung disease using administrative and claims data. (22262614)
2012
21
Interstitial lung disease outcomes by high-resolution computed tomography (HRCT) in Anti-Jo1 antibody-positive polymyositis patients: a single centre study and review of the literature. (21985773)
2012
22
Texture feature ranking with relevance learning to classify interstitial lung disease patterns. (23010586)
2012
23
Fatal asymmetric interstitial lung disease after erlotinib for lung cancer. (22889962)
2012
24
Efficacy of blood-patch pleurodesis for secondary spontaneous pneumothorax in interstitial lung disease. (21628929)
2011
25
Overlaps in interstitial lung disease--worth a second glance. (21401701)
2011
26
Airway and interstitial lung disease are distinct entities in paediatric common variable immunodeficiency. (21635229)
2011
27
Prediction of acute pulmonary complications after resection of lung cancer in patients with preexisting interstitial lung disease. (21480134)
2011
28
Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease. (21547897)
2011
29
Successful erlotinib rechallenge after erlotinib-induced interstitial lung disease. (21623280)
2011
30
Quantitative computed tomographic indexes in diffuse interstitial lung disease: correlation with physiologic tests and computed tomography visual scores. (21412102)
2011
31
Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis. (20506355)
2010
32
Aspects of interstitial lung disease review series. (20478853)
2010
33
N-acetylcysteine inhibits IL-8 and MMP-9 release and ICAM-1 expression by bronchoalveolar cells from interstitial lung disease patients. (20360623)
2010
34
Connective tissue disease-associated interstitial lung disease: a call for clarification. (20682528)
2010
35
Rheumatoid arthritis and interstitial lung disease. (20223815)
2010
36
Essential role of osteopontin in smoking-related interstitial lung diseases. (19359522)
2009
37
Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients. (19615053)
2009
38
Adult clinically amyopathic dermatomyositis with rapid progressive interstitial lung disease: a retrospective cohort study. (17308858)
2007
39
In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. (16507114)
2006
40
A case of interstitial lung disease with atorvastatin (Tahor) and a review of the literature about these effects observed under statins]. (16792155)
2006
41
Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD). (15716315)
2005
42
Interstitial lung disease in polymyositis and dermatomyositis. (16224246)
2005
43
Serial chest CT findings in interstitial lung disease associated with polymyositis-dermatomyositis. (14962653)
2004
44
Interstitial lung disease in polymyositis and dermatomyositis: clinical course and response to treatment. (12701038)
2003
45
Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease. (16088687)
2001
46
Human bronchoalveolar lavage fluid protein two-dimensional database: study of interstitial lung diseases. (10949149)
2000
47
Increased incidence of autoantibodies to interleukin-1a in rheumatoid arthritis with interstitial lung disease. (11192540)
2000
48
CYFRA 21-1, a cytokeratin subunit 19 fragment, in bronchoalveolar lavage fluid from patients with interstitial lung disease. (9682677)
1998
49
High resolution CT in respiratory bronchiolitis-associated interstitial lung disease. (8419438)
1993
50
Mast cells, atypical lymphocytes, and neutrophils in bronchoalveolar lavage in extrinsic allergic alveolitis. Comparison with other interstitial lung diseases. (2432812)
1987

Genetic Variations for Interstitial Lung Disease

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Expression for genes affiliated with Interstitial Lung Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Interstitial Lung Disease

Search GEO for disease gene expression data for Interstitial Lung Disease.

Pathways for genes affiliated with Interstitial Lung Disease

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Sources:
51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Interstitial Lung Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.0CCL22, CCL18, SFTPC, SFTPD, SFTPB, S100A9
2dexamethasone44 49 28 1114.0CXCL9, CCL22, CCL18, SFTPC, SFTPD, SFTPB
3tarc4410.9CCL22, CCL18, CXCL5, CXCL9
4ccl344 2811.9CXCL9, CXCL5, CCL18, CCL22
5ccl444 2811.9CCL22, CCL18, CXCL5, CXCL9
6fibrinogen4410.9CCL22, SFTPC, SFTPB, S100A9, CHIT1
7infasurf4410.8SFTPB, SFTPC
8rantes4410.8CXCL5
9dppg4410.8SFTPC, SFTPB
10popg4410.8SFTPC, SFTPB
111,2-dipalmitoyl-sn-glycero-3-phosphocholine4410.8SFTPC, SFTPB
12ena 784410.8CXCL5, CXCL9
13curosurf4410.8SFTPC, SFTPB
14nitric oxide44 11 2412.7SFTPD, SFTPB, S100A9, CXCL5, CXCL9, TAC3
15endotoxin4410.7CXCL5, S100A9
16dopc4410.7SFTPC, SFTPB
17survanta4410.7SFTPC, SFTPB
18dppc4410.6SFTPB, SFTPC
19butanol4410.6SFTPC, SFTPB
20vegf4410.6CXCL9, CXCL5, SFTPB, SFTPC, CCL18
21p-opc4410.5SFTPC, SFTPB
22chloroform4410.4SFTPC, SFTPB
23larc4410.2CCL18, CCL22

GO Terms for genes affiliated with Interstitial Lung Disease

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Sources:
16Gene Ontology
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Cellular components related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SFTPD, S100A9, SCGB3A2, CD27, CXCL5, CXCL9
2extracellular spaceGO:00561510.4TAC3, CCL22, CCL18, SFTPC, SFTPD, SFTPB

Biological processes related to Interstitial Lung Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726710.7CXCL9, CXCL5, CD70, S100A9, CCL18, CCL22
2immune responseGO:00695510.7CCL22, CCL18, CHIT1, CD70, CXCL5, CXCL9
3chemotaxisGO:00693510.6CXCL9, CXCL5, CCL18, CCL22
4inflammatory responseGO:00695410.6CCL22, CCL18, S100A9, CXCL9, IL27
5response to bacteriumGO:00961710.5IL27, CHIT1
6respiratory gaseous exchangeGO:00758510.4SFTPB, SFTPD, SFTPC
7signal transductionGO:00716510.3CCL22, CCL18, S100A9, CD70, CXCL5, CXCL9

Molecular functions related to Interstitial Lung Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.5CXCL9, CXCL5, CCL18, CCL22

Products for genes affiliated with Interstitial Lung Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Interstitial Lung Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet