MCID: INT067
MIFTS: 45

Interstitial Nephritis

Categories: Nephrological diseases

Aliases & Classifications for Interstitial Nephritis

MalaCards integrated aliases for Interstitial Nephritis:

Name: Interstitial Nephritis 12 14
Nephritis, Interstitial 42 69
Renal Tubulo-Interstitial Disease 12
Nephritis, Tubulointerstitial 69
Nephritis Interstitial 52

Classifications:



External Ids:

Disease Ontology 12 DOID:1063
MeSH 42 D009395
NCIt 47 C26834
SNOMED-CT 64 264536006 28689008
UMLS 69 C0027707

Summaries for Interstitial Nephritis

MalaCards based summary : Interstitial Nephritis, also known as nephritis, interstitial, is related to pyelonephritis and polyarteritis nodosa. An important gene associated with Interstitial Nephritis is FAN1 (FANCD2 And FANCI Associated Nuclease 1), and among its related pathways/superpathways are Peptide hormone metabolism and Renin secretion. The drugs Prednisone and Asparaginase have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and t cells, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 72 Interstitial nephritis (or tubulo-interstitial nephritis). is a form of nephritis affecting the... more...

Related Diseases for Interstitial Nephritis

Diseases related to Interstitial Nephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
id Related Disease Score Top Affiliating Genes
1 pyelonephritis 31.2 ACE CRP REN
2 polyarteritis nodosa 30.2 ALB CRP
3 xanthogranulomatous pyelonephritis 28.5 ACE AGT ALB CRP REN
4 choroiditis 28.5 ACE ALB CRP UMOD
5 interstitial nephritis, karyomegalic 12.5
6 megalocytic interstitial nephritis 12.4
7 balkan nephropathy 11.1
8 hypoaldosteronism 10.9
9 nephronophthisis 16 10.9
10 nephronophthisis 2, infantile 10.9
11 nephronophthisis 15 10.9
12 nephronophthisis 20 10.9
13 chronic pyelonephritis 10.7
14 hypothyroidism due to iodide transport defect 10.6 ACE REN
15 wernicke-korsakoff syndrome 10.6 ALB REN
16 retinitis pigmentosa 70 10.6 ACE ALB
17 iga glomerulonephritis 10.6 ALB REN
18 primary hyperoxaluria 10.6 ACE REN
19 atrial septal defect 7, with or without av conduction defects 10.6 ACE REN
20 mody, type ii 10.6 ACE REN
21 hypodontia of incisors and premolars 10.6 ACE REN
22 listeriosis 10.6 ACE REN
23 synovial chondromatosis 10.6 ACE ALB
24 clitoris cancer 10.6 ACE REN
25 spondyloepimetaphyseal dysplasia, camera-genevieve type 10.5 ANKS6 INVS MAPKBP1
26 voyeurism 10.5 ACE REN
27 capillary leak syndrome 10.5 ALB CRP
28 iron metabolism disease 10.5 ACE CRP
29 speech and communication disorders 10.5 ALB CRP
30 acute pyelonephritis 10.5
31 milker's nodule 10.5 ALB CRP
32 pelizaeus-merzbacher-like disease 10.5 ACE AGT
33 cryptogenic organizing pneumonia 10.5 ALB CRP
34 chronic diarrhea due to guanylate cyclase 2c overactivity 10.5 ACE CRP
35 pyelitis 10.4
36 heart disease 10.4 ACE CRP
37 dermatomycosis 10.4 ALB CRP
38 cataract, autosomal dominant congenital 4 10.4 ACE AGT
39 pyrimidine metabolic disorder 10.4 ALB CRP
40 potato nose 10.4 ACE AGT
41 microcephaly 8, primary, autosomal recessive 10.4 ALB CRP
42 islet cell tumor 10.4 ACE CRP
43 aortopulmonary window 10.4 ACE AGT
44 glycogen storage disease viii 10.3 CRP REN
45 placental abruption 10.3 ACE CRP
46 eustachian tube disease 10.3 CRP REN
47 trichinosis 10.3 ACE AGT
48 non-congenital cyst of kidney 10.3 ACE ALB REN
49 hypoaldosteronism, congenital, due to cmo ii deficiency 10.3 AGT REN
50 myopia 10.3 ACE ALB REN

Graphical network of the top 20 diseases related to Interstitial Nephritis:



Diseases related to Interstitial Nephritis

Symptoms & Phenotypes for Interstitial Nephritis

MGI Mouse Phenotypes related to Interstitial Nephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 ACE AGT ALB APRT CRP HRH2
2 liver/biliary system MP:0005370 9.35 ACE AGT ALB ANKS6 INVS
3 renal/urinary system MP:0005367 9.17 UMOD ACE AGT ALB APRT INVS

Drugs & Therapeutics for Interstitial Nephritis

Drugs for Interstitial Nephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
2
Asparaginase Approved Phase 3 9015-68-3
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
5
Daunorubicin Approved Phase 3 20830-81-3 30323
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
7
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
8
Etoposide Approved Phase 3 33419-42-0 36462
9
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
10
Ifosfamide Approved Phase 3 3778-73-2 3690
11
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
12
Pegaspargase Approved, Investigational Phase 3 130167-69-0
13
Thioguanine Approved Phase 3 154-42-7 2723601
14
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
15
Vindesine Approved Phase 3 59917-39-4, 53643-48-4 40839
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
18
Doxil Approved June 1999 Phase 3 31703
19 Adrenocorticotropic Hormone Phase 2, Phase 3
20 beta-endorphin Phase 2, Phase 3
21 Bone Density Conservation Agents Phase 2, Phase 3
22 Calcium, Dietary Phase 2, Phase 3
23 Endorphins Phase 2, Phase 3
24 Hormone Antagonists Phase 2, Phase 3
25 Hormones Phase 2, Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
27 Melanocyte-Stimulating Hormones Phase 2, Phase 3
28 Neurotransmitter Agents Phase 2, Phase 3
29 Antirheumatic Agents Phase 3,Phase 1,Phase 2
30 Gastrointestinal Agents Phase 3
31 Anti-Inflammatory Agents Phase 3,Phase 2
32 Antineoplastic Agents, Hormonal Phase 3,Phase 2
33 glucocorticoids Phase 3,Phase 2
34 6-Mercaptopurine Phase 3
35 Alkylating Agents Phase 3
36 Anti-Bacterial Agents Phase 3
37 Antibiotics, Antitubercular Phase 3
38 Antiemetics Phase 3
39 Anti-Infective Agents Phase 3
40 Antimetabolites Phase 3
41 Antimetabolites, Antineoplastic Phase 3
42 Antimitotic Agents Phase 3
43 Antineoplastic Agents, Phytogenic Phase 3
44 Antiviral Agents Phase 3
45 Autonomic Agents Phase 3
46 BB 1101 Phase 3
47 Dermatologic Agents Phase 3
48 Dexamethasone acetate Phase 3 1177-87-3
49 Etoposide phosphate Phase 3
50 Folic Acid Antagonists Phase 3

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study Unknown status NCT02155803 Phase 2, Phase 3 ACTHAR Gel (adrenocorticotropic hormone)
2 International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia Active, not recruiting NCT01117441 Phase 3 PEG-L-asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine;daunoxome;fludarabine
3 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
4 Xolair (Omalizumab) for Treatment of Drug-induced Acute Tubulointerstitial Nephritis (AIN) Recruiting NCT01893658 Phase 2 Omalizumab;Prednisone
5 Anti-BK Virus Immune Response and Kidney Transplantation Unknown status NCT01109186
6 Evaluation of a Predictive Immunovirological Test Occurrence of BK Virus Nephropathy in Renal Transplant Unknown status NCT02049827
7 Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists Completed NCT01338363
8 Hereditary Tubulointerstitial Nephritis Completed NCT01312727
9 Monitoring of Biopsy-Proven Interstitial Polyomavirus Nephritis in Kidney and Kidney Pancreas Transplant Recipients Completed NCT00374283
10 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695
11 Involvement of Polyomaviruses in the Pathogenesis of Autoimmune Thyroiditis and Goitrigenesis. Recruiting NCT03103776
12 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
13 Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis Recruiting NCT02811770

Search NIH Clinical Center for Interstitial Nephritis

Cochrane evidence based reviews: nephritis, interstitial

Genetic Tests for Interstitial Nephritis

Anatomical Context for Interstitial Nephritis

MalaCards organs/tissues related to Interstitial Nephritis:

39
Kidney, Bone, T Cells, Pancreas, Thyroid, Testes, Liver

Publications for Interstitial Nephritis

Articles related to Interstitial Nephritis:

(show top 50) (show all 641)
id Title Authors Year
1
Cyclooxygenase-2 inhibitor-induced acute interstitial nephritis. ( 28536229 )
2017
2
Allergic Interstitial Nephritis Masquerading as Pyelonephritis in a Pediatric Patient With Crohn Disease. ( 28644363 )
2017
3
A case report of zinc phosphide poisoning: complicated by acute renal failure and tubulo interstitial nephritis. ( 28545504 )
2017
4
Acute granulomatous interstitial nephritis and acute rejection in a kidney transplant recipient after zoledronic acid therapy - a case report and review of the literature. ( 28655390 )
2017
5
Acute Interstitial Nephritis Associated with Sofosbuvir and Daclatasvir. ( 28706960 )
2017
6
Clinical profile and outcome of patients with biopsy-proven acute interstitial nephritis in Cape Town: a 10-year reviewa8c. ( 28438256 )
2017
7
Urine Eosinophils for Acute Interstitial Nephritis. ( 28459905 )
2017
8
Acute kidney injury with granulomatous interstitial nephritis and vasculitis revealing sarcoidosis. ( 28937078 )
2017
9
AJKD Atlas of Renal Pathology: Chronic Interstitial Nephritis. ( 28646984 )
2017
10
Acute interstitial nephritis after sequential ipilumumab - nivolumab therapy of metastatic melanoma. ( 28716106 )
2017
11
Undiagnosed renal sarcoidosis in a patient with chronic interstitial nephritis. ( 28875342 )
2017
12
Drug-Induced Acute Interstitial Nephritis. ( 28893923 )
2017
13
Case 6: Skin Discoloration, Methemoglobinemia, and Acute Interstitial Nephritis in a 15-year-old Girl. ( 28765205 )
2017
14
Acute Ciprofloxacin-Induced Crystal Nephropathy with Granulomatous Interstitial Nephritis. ( 28553048 )
2017
15
Acute interstitial nephritis and DRESS syndrome without eosinophilia associated with cefepime. ( 28775112 )
2017
16
IgG4-Related Disease Manifesting as Interstitial Nephritis Accompanied by Hypophysitis. ( 28552902 )
2017
17
Infection associated acute interstitial nephritis; a case report. ( 28491853 )
2017
18
Novel oral anticoagulant and kidney injury: apixaban-related acute interstitial nephritis. ( 28847995 )
2017
19
Ibuprofen-induced acute interstitial nephritis in the paediatric population. ( 26669585 )
2016
20
Effective Treatment With Everolimus for Recurrent Granulomatous Interstitial Nephritis in a Renal Transplant Recipient: A Case Report. ( 27234775 )
2016
21
A FANCD2/FANCI-Associated Nuclease 1-Knockout Model Develops Karyomegalic Interstitial Nephritis. ( 27026368 )
2016
22
Acute interstitial nephritis in T-cell leukemia in a pediatric patient. ( 27594450 )
2016
23
Karyomegalic interstitial nephritis. ( 28509177 )
2016
24
Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice. ( 26980188 )
2016
25
Drug-Induced Acute Interstitial Nephritis with Nifedipine. ( 26955492 )
2016
26
Monotypic plasma cell interstitial nephritis as the only clinical manifestation in a patient with previously undiagnosed indolent multiple myeloma: A case report. ( 27495052 )
2016
27
Ertapenem-Induced Acute Interstitial Nephritis (AIN) in a Case of Protein S Deficiency and Factor V Leiden Mutation with Deep Vein Thrombosis. ( 27731567 )
2016
28
Acute Interstitial Nephritis Following Snake Envenomation: A Single-Center Experience. ( 26970860 )
2016
29
Successful management of acute interstitial nephritis in two cases of disseminated tuberculosis. ( 27729256 )
2016
30
Granulomatous interstitial nephritis and Crohn's disease. ( 27478596 )
2016
31
Erratum: Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma. ( 27478613 )
2016
32
Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants. ( 27738229 )
2016
33
Acute Interstitial Nephritis Secondary to Metamizole; The Rise of Drug Tourism. ( 27834095 )
2016
34
Karyomegalic Interstitial Nephritis: A Case Report and Review of the Literature. ( 27196444 )
2016
35
A rare case of lamotrigine-induced acute interstitial nephritis. ( 27987281 )
2016
36
Acute interstitial nephritis, toxic hepatitis and toxic myocarditis following multiple Asian giant hornet stings in Shaanxi Province, China. ( 26910407 )
2016
37
Acute interstitial nephritis induced by Solanum nigrum. ( 27957421 )
2016
38
The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis. ( 26798465 )
2016
39
AJKD Atlas of Renal Pathology: Acute Interstitial Nephritis. ( 27211376 )
2016
40
Acute interstitial nephritis due to flecainide therapy in the 38(th) week of pregnancy. ( 26980436 )
2016
41
Acute interstitial nephritis caused by two different proton pump inhibitors. ( 26903459 )
2016
42
Chronic kidney disease of uncertain etiology in Sri Lanka is a possible sequel of interstitial nephritis! ( 27469156 )
2016
43
Piperacillin-Tazobactam Induced Interstitial Nephritis, Hepatitis and Serum Sckness-Like Illness. ( 27434982 )
2016
44
Acute interstitial nephritis with membranous nephropathy in bucillamine-treated rheumatoid arthritis. ( 28509179 )
2016
45
Acute interstitial nephritis related to immune checkpoint inhibitors. ( 27832664 )
2016
46
Regression of a Pulmonary Arteriovenous Malformation after Acute Interstitial Nephritis. ( 27250058 )
2016
47
COXPD9 an Evolving Multisystem Disease; Congenital Lactic Acidosis, Sensorineural Hearing Loss, Hypertrophic Cardiomyopathy, Cirrhosis and Interstitial Nephritis. ( 27815843 )
2016
48
Granulomatous interstitial nephritis associated with influenza A: H1N1 infection--A case report. ( 27483570 )
2016
49
Reversible Fluindione-Induced Chronic Interstitial Nephritis. ( 27127666 )
2016
50
Minimal-change disease and interstitial nephritis secondary to non-steroidal anti-inflammatory drugs (naproxen). ( 27203163 )
2016

Variations for Interstitial Nephritis

Expression for Interstitial Nephritis

Search GEO for disease gene expression data for Interstitial Nephritis.

Pathways for Interstitial Nephritis

Pathways related to Interstitial Nephritis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.39 ACE AGT REN
2 10.61 ACE AGT REN

GO Terms for Interstitial Nephritis

Cellular components related to Interstitial Nephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 ACE AGT ALB APRT CRP REN

Biological processes related to Interstitial Nephritis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.63 ACE AGT REN
2 regulation of blood pressure GO:0008217 9.54 ACE AGT REN
3 positive regulation of protein tyrosine kinase activity GO:0061098 9.51 ACE AGT
4 blood vessel remodeling GO:0001974 9.49 ACE AGT
5 regulation of vasoconstriction GO:0019229 9.48 ACE AGT
6 beta-amyloid metabolic process GO:0050435 9.43 ACE REN
7 positive regulation of superoxide anion generation GO:0032930 9.4 AGT CRP
8 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.32 ACE AGT
9 renin-angiotensin regulation of aldosterone production GO:0002018 9.26 AGT REN
10 regulation of blood volume by renin-angiotensin GO:0002016 9.16 AGT REN
11 regulation of renal output by angiotensin GO:0002019 8.96 ACE AGT
12 angiotensin maturation GO:0002003 8.8 ACE AGT REN

Sources for Interstitial Nephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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