MCID: INT067
MIFTS: 49

Interstitial Nephritis malady

Nephrological category

Summaries for Interstitial Nephritis

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64Wikipedia, 33MalaCards
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Wikipedia:64 Interstitial nephritis (or Tubulo-interstitial nephritis) is a form of nephritis affecting the... more...

MalaCards: Interstitial Nephritis, also known as renal tubulo-interstitial disease, is related to nephritis and diabetic nephropathy. An important gene associated with Interstitial Nephritis is FAN1 (FANCD2/FANCI-associated nuclease 1), and among its related pathways are Ifosfamide Pathway, Pharmacokinetics and Histamine receptors. The compounds pge2 and aliskiren have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Interstitial Nephritis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Interstitial Nephritis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Interstitial Nephritis:



Diseases related to interstitial nephritis

Clinical Features for Interstitial Nephritis

Drugs & Therapeutics for Interstitial Nephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Interstitial Nephritis

Drug clinical trials:

Search ClinicalTrials for Interstitial Nephritis

Search NIH Clinical Center for Interstitial Nephritis

Search CenterWatch for Interstitial Nephritis

Genetic Tests for Interstitial Nephritis

Anatomical Context for Interstitial Nephritis

Animal Models for Interstitial Nephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Interstitial Nephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1MB, CTNS, RBP4, AGT, REN, PTGS1
2MP:00053678.5TIMP3, CTNS, ATP12A, OCRL, AGTR1, AGT
3MP:00053767.5PTGS1, TIMP3, MB, CTNS, RBP4, ATP12A

Publications for Interstitial Nephritis

Sources:
51PubMed
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Articles related to Interstitial Nephritis:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Quantitative evaluation of interstitial fibrosis with Sirius Red in IgA nephritis. (24028638)
2014
2
Pantoprazole-induced acute interstitial nephritis. (23109611)
2013
3
Keep an eye out for tubulo-interstitial nephritis. (24394738)
2013
4
Interstitial inflammation and long-term renal outcomes in lupus nephritis. (24097970)
2013
5
Ipilimumab Granulomatous Interstitial Nephritis. (24067875)
2013
6
Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme. (23235917)
2013
7
Acute interstitial nephritis after amoxycillin with hematuria, red blood cell casts and hematuria-induced acute tubular injury. (22607916)
2013
8
Interstitial nephritis and autoimmune pancreatitis: a case report. (21069569)
2012
9
Prolonged adefovir therapy associated Fanconi syndrome and interstitial nephritis in hepatitis B. (22906032)
2012
10
Membranous nephropathy and granulomatous interstitial nephritis due to tuberculosis. (22105453)
2011
11
Acute interstitial nephritis. (20336051)
2010
12
Long-term preserved renal function of a patient with mass-forming granulomatous interstitial nephritis by biopsy-based steroid therapy. (20798972)
2010
13
Clozapine-induced interstitial nephritis - a rare but important complication: a case report. (20126316)
2009
14
Acute interstitial nephritis during rifampicin therapy can be a paradoxical response: a case report. (20181173)
2009
15
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
16
Karyomegalic interstitial nephritis: a pitfall in urine cytology. (17304531)
2007
17
Candidemia-induced acute interstitial nephritis. (17803479)
2007
18
Rosiglitazone as a cause of acute interstitial nephritis. (16507580)
2006
19
Tubulo-interstitial nephritis and uveitis syndrome in a 6-year-old boy: case report. (16709335)
2006
20
Hypertension in Page (cellophane-wrapped) kidney is due to interstitial nephritis. (16105047)
2005
21
Acute granulomatous interstitial nephritis secondary to bisphosphonate alendronate sodium. (16060139)
2005
22
Rare causes of interstitial nephritis in two children]. (16060093)
2005
23
Interstitial nephritis from mesalazine: case report and literature review. (15007714)
2004
24
Chronic overdose of leflunomide inducing interstitial nephritis. (15102985)
2004
25
Granulomatous interstitial nephritis due to isolated renal sarcoidosis. (15480909)
2004
26
Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit. (15004262)
2004
27
Diagnosis and management of acute interstitial nephritis. (12825841)
2003
28
BK polyomavirus interstitial nephritis in a renal allograft recipient. (12554538)
2003
29
Rofecoxib-induced acute interstitial nephritis. (12613001)
2003
30
Quiz page. Diabetic nephropathy with superimposed acute interstitial nephritis. (12776302)
2003
31
Late-onset cytomegalovirus-associated interstitial nephritis in a kidney transplant. (12218340)
2002
32
Diabetic nephropathy with interstitial nephritis presenting with a false-positive anti-GBM antibody. (12036199)
2002
33
Isolated sarcoid granulomatous interstitial nephritis: review of five cases at one center. (11334315)
2001
34
Idiopathic hypocomplementemic interstitial nephritis with extensive tubulointerstitial deposits. (11157382)
2001
35
Trauma-related xanthogranulomatous interstitial nephritis: a clinicopathological analysis. (11835740)
2001
36
Norfloxacin-induced acute interstitial nephritis. (11015000)
2000
37
Genetic mapping of a locus associated with bovine chronic interstitial nephritis to chromosome 1. (10782206)
2000
38
Images in nephrology. Interstitial nephritis and nephrotic syndrome in a patient from Zambia. (10328496)
1999
39
Glomerular, tubular and interstitial nephritis associated with non-steroidal antiinflammatory drugs. Evidence of a common mechanism. (10190656)
1999
40
Human polyoma virus-associated interstitial nephritis in the allograft kidney. (9921805)
1999
41
Cholesterol embolism and acute interstitial nephritis: two adverse effects of streptokinase thrombolytic therapy in the same patient. (9623565)
1998
42
Late onset interstitial nephritis associated with mesalazine treatment. (9740571)
1998
43
Idiopathic acute granulomatous interstitial nephritis leading to renal papillary necrosis. (9175068)
1997
44
The diagnosis and racial origin of 394 patients undergoing renal biopsy: an association between Indian race and interstitial nephritis. (9027776)
1997
45
Omeprazole-induced interstitial nephritis. (9412948)
1997
46
Enzymuria as early marker of interstitial nephritis. (9241538)
1997
47
Hereditary interstitial nephritis without basement membrane changes. (7777106)
1995
48
Megalocytic interstitial nephritis (a case report). (3781615)
1986
49
Fenoprofen nephropathy: lipoid nephrosis and interstitial nephritis. A possible T-lymphocyte disorder. (6977270)
1982
50
Congenital unilateral renal hypoplasia complicated by chronic interstitial nephritis in a dog. (4489767)
1973

Genetic Variations for Interstitial Nephritis

Expression for genes affiliated with Interstitial Nephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Interstitial Nephritis

Search GEO for disease gene expression data for Interstitial Nephritis.

Pathways for genes affiliated with Interstitial Nephritis

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Interstitial Nephritis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Interstitial Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1pge24510.3MB, REN, EDN3
2aliskiren45 1111.2AGTR1, AGT, REN
3saralasin4510.2REN, AGTR1, AGT
4eprosartan45 29 1112.2REN, AGTR1, AGT
5benazepril45 1111.2AGT, AGTR1, REN
6inositol 1,4,5 trisphosphate4510.2OCRL, EDN3, HRH1
7norepinephrine45 11 2412.1HRH1, EDN3, MB
8olmesartan45 29 1112.1AGTR1, AGT, REN
9lisinopril45 11 2412.0AGTR1, REN, AGT
10diclofenac45 29 50 1113.0MB, PTGS1, HRH2, CYP2C19
11irbesartan45 29 50 1113.0PTGS1, REN, AGTR1, AGT
12candesartan45 29 1112.0AGT, AGTR1, REN, PTGS1
13captopril45 29 50 60 1114.0AGTR1, AGT, EDN3, REN
14telmisartan45 29 1112.0AGTR1, CYP2C19, AGT, REN
15diphenhydramine45 29 2 11 2414.0HRH1, CYP2C19, HRH2, PTGS1
16diltiazem45 29 1112.0AGT, AGTR1, REN, CYP2C19
17chymostatin4510.0REN, AGT, AGTR1
18deoxyribonucleic acid4510.0TIMP3, AGTR1, CT49, AGT
19lansoprazole50 45 11 2413.0ATP4A, CYP2C19, HRH2
20hydrogen45 2411.0EDN3, MB, AGTR1, CYP2C19, HRH2
21pantoprazole45 50 11 2413.0CYP2C19, ATP4A, ATP12A, HRH2
22acetaminophen45 2 50 11 2413.9AGTR1, PTGS1, HRH2, CYP2C19
23imidazole459.9MB, AGTR1, HRH1, HRH2
24atenolol45 29 50 11 2413.9REN, AGTR1, AGT
25digoxin45 50 60 11 2413.9HRH2, AGTR1, HRH1, REN
26sodium nitroprusside459.9REN, AGTR1, MB, EDN3, PTGS1
27thromboxane a245 2410.9AGT, AGTR1, PTGS1, EDN3
28valsartan45 60 29 1112.9AGTR1, AGT, REN
29losartan45 50 29 1112.8CYP2C19, REN, AGT, AGTR1
30nifedipine45 50 29 1112.8EDN3, AGTR1, AGT, CYP2C19, REN
31perindopril45 50 1111.8AGT, REN, AGTR1
32prostacyclin459.7REN, AGT, AGTR1, EDN3, PTGS1
33cgmp45 2910.7AGT, REN, AGTR1, HRH1, EDN3
34isoproterenol45 1110.6AGTR1, AGT, REN, HRH2, HRH1
35epinephrine45 11 2411.5AGTR1, AGT, MB, HRH2, HRH1, REN
36indomethacin45 60 29 1112.5REN, PTGS1, EDN3, AGT, CYP2C19, HRH1
37haloperidol45 29 2 50 1113.5CYP2C19, HRH1, REN, AGT, AGTR1, MB
38oxygen45 2410.5HRH2, CYP2C19, AGT, PTGS1, MB, TIMP3
39estradiol45 11 2411.4TIMP3, REN, CYP2C19, AGT, AGTR1, CT49
40prostaglandin459.4HRH2, EDN3, AGTR1, AGT, REN, PTGS1
41arachidonic acid45 29 11 2412.4HRH1, CYP2C19, AGT, AGTR1, EDN3, PTGS1
42vegf459.3AGT, AGTR1, REN, PTGS1, EDN3, CT49
43adenylate459.2RBP4, HRH2, HRH1, AGT, EDN3, MB
44creatinine459.2REN, MB, RBP4, OCRL, AGTR1, AGT
45dopamine45 29 11 2412.2AGTR1, CYP2C19, HRH1, REN, AGT, RBP4
46potassium45 11 2411.1EDN3, ATP12A, AGTR1, HRH1, REN, ATP4A
47nitric oxide45 11 2411.1HRH1, REN, CYP2C19, AGT, HRH2, AGTR1
48dexamethasone45 50 29 1112.0TIMP3, EDN3, RBP4, AGTR1, AGT, CYP2C19
49alanine458.9MB, EDN3, RBP4, AGTR1, HRH1, PTGS1
50lipid458.5HRH2, TIMP3, CYP2C19, RBP4, OCRL, AGTR1

GO Terms for genes affiliated with Interstitial Nephritis

Sources:
16Gene Ontology
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Cellular components related to Interstitial Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi-associated vesicleGO:00579810.0OCRL, STK16

Biological processes related to Interstitial Nephritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
3artery smooth muscle contractionGO:01482410.3EDN3, AGT
4regulation of renal sodium excretionGO:03581310.3AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
6regulation of vasoconstrictionGO:01922910.2EDN3, AGTR1, AGT
7inositol phosphate-mediated signalingGO:04801610.1HRH1, EDN3
8low-density lipoprotein particle remodelingGO:03437410.1AGT, AGTR1
9renin-angiotensin regulation of aldosterone productionGO:00201810.1REN, AGT, AGTR1
10positive regulation of cellular protein metabolic processGO:03227010.0AGTR1, AGT
11positive regulation of macrophage derived foam cell differentiationGO:01074410.0AGT, AGTR1
12visual learningGO:00854210.0HRH2, HRH1, CTNS
13phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.9AGTR1, AGT, HRH1
14kidney developmentGO:0018229.9AGTR1, AGT, REN
15angiotensin maturationGO:0020039.9AGT, REN
16regulation of cell proliferationGO:0421279.5PTGS1, AGT, AGTR1

Molecular functions related to Interstitial Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histamine receptor activityGO:00496910.0HRH2, HRH1
2acetyltransferase activator activityGO:0106989.9AGT, AGTR1
3hydrogen:potassium-exchanging ATPase activityGO:0089009.6ATP4A, ATP12A

Products for genes affiliated with Interstitial Nephritis

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Sources for Interstitial Nephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet