MCID: INT067
MIFTS: 57

Interstitial Nephritis malady

Nephrological diseases category

Summaries for Interstitial Nephritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Interstitial nephritis (or tubulo-interstitial nephritis) is a form of nephritis affecting the... more...

MalaCards: Interstitial Nephritis, also known as renal tubulo-interstitial disease, is related to hepatitis and primary hyperoxaluria. An important gene associated with Interstitial Nephritis is FAN1 (FANCD2/FANCI-associated nuclease 1), and among its related pathways are Ifosfamide Pathway, Pharmacokinetics and Histamine receptors. The compounds pge2 and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and liver, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Interstitial Nephritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Interstitial Nephritis

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17GeneCards, 18GeneDecks
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Diseases related to Interstitial Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.8HRH2
2primary hyperoxaluria30.7AGTR1, AGT, REN
3nephrotic syndrome30.7AGT, RBP4
4glomerulonephritis30.6AGTR1, RBP4, EDN3
5proteinuria30.4RBP4, AGTR1, AGT, REN
6hypertension30.2REN, AGT, AGTR1
7leukemia30.2RBP4, HRH1, HRH2, PTGS1
8diabetic nephropathy30.2TIMP3, RBP4, AGTR1, AGT, REN
9congestive heart failure30.0REN
10rheumatoid arthritis30.0PTGS1, HRH1, MB, TIMP3
11arthritis30.0PTGS1, HRH2, AGTR1, MB, TIMP3
12pneumonia30.0MB, RBP4, ATP12A, ATP4A, HRH1, HRH2
13chronic kidney failure30.0EDN3, RBP4, AGTR1, AGT, REN, HRH1
14uveitis10.7
15sarcoidosis10.6
16gitelman syndrome10.5
17multicystic renal dysplasia, bilateral10.5
18transient pseudohypoaldosteronism10.5
19megalocytic interstitial nephritis10.5
20fanconi syndrome10.4
21pyelonephritis10.4
22vasculitis10.4
23crohn's disease10.4
24eosinophilia10.4
25karyomegalic interstitial nephritis10.4
26wegener's granulomatosis10.3
27inflammatory bowel disease10.3
28retinitis10.3
29tuberculosis10.3
30stricture or kinking of ureter10.3
31urinary tract obstruction10.3
32vesicoureteral reflux 210.3
33retinitis pigmentosa10.2
34bronchitis10.2
35hepatitis a10.2
36amyloidosis10.2
37chronic pyelonephritis10.2
38histoplasmosis10.2
39membranous glomerulonephritis10.2
40lipoid nephrosis10.2
41xanthogranulomatous pyelonephritis10.2
42diabetes insipidus10.2
43end stage renal failure10.2
44ulcerative colitis10.2
45hypercalcemia10.2
46mantle cell lymphoma10.2
47nephrogenic diabetes insipidus10.2
48chronic lymphocytic leukemia10.2
49dermatitis10.2
50acute liver failure10.0

Graphical network of the top 20 diseases related to Interstitial Nephritis:



Diseases related to interstitial nephritis

Clinical Features for Interstitial Nephritis

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Drugs & Therapeutics for Interstitial Nephritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Interstitial Nephritis

Drug clinical trials:

Search ClinicalTrials for Interstitial Nephritis

Search NIH Clinical Center for Interstitial Nephritis

Search CenterWatch for Interstitial Nephritis

Genetic Tests for Interstitial Nephritis

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Anatomical Context for Interstitial Nephritis

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32MalaCards
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MalaCards organs/tissues related to Interstitial Nephritis:

32
Kidney, T cells, Liver, Bone, B cells, Lung, Bone marrow, Monocytes, Thyroid, Heart, Eye, Pancreas

Animal Models for Interstitial Nephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Interstitial Nephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1MB, CTNS, RBP4, AGT, REN, PTGS1
2MP:00053678.5TIMP3, CTNS, ATP12A, OCRL, AGTR1, AGT
3MP:00053767.5PTGS1, TIMP3, MB, CTNS, RBP4, ATP12A

Publications for Interstitial Nephritis

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50PubMed
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Articles related to Interstitial Nephritis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
2
Cefpodoxime proxetil-related hemolysis and acute interstitial nephritis. (23845192)
2013
3
Karyomegalic interstitial nephritis. (23831142)
2013
4
Idiopathic Granulomatous Interstitial Nephritis Responsive to Mycophenolate Mofetil Therapy. (24315767)
2013
5
A diagnostic conundrum: acute interstitial nephritis due to armodafinil versus acute cellular rejection in a renal transplant recipient--a case report. (23498834)
2013
6
Tubulo-interstitial nephritis and uveitis with Fanconi syndrome. (22466281)
2012
7
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. (22147390)
2012
8
Cytomegalovirus induced interstitial nephritis and ureteral stenosis in renal transplant recipient. (23269892)
2012
9
Drug-induced acute interstitial nephritis mimicking acute tubular necrosis after initiation of tenofovir-containing antiretroviral therapy in patient with HIV-1 infection. (22975570)
2012
10
Chronic interstitial nephritis in an HIV type-1-infected patient receiving ritonavir-boosted atazanavir. (21311116)
2011
11
Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pathway. (21795690)
2011
12
Acute renal failure due to immune reconstitution inflammatory interstitial nephritis in an HIV-positive patient. (20588107)
2010
13
Mesalazine-induced interstitial nephritis. (19212915)
2009
14
A case of Mikulicz's disease complicated with severe interstitial nephritis associated with IgG4. (19142575)
2009
15
Acute interstitial nephritis complicating a new diagnosis of Wegener's granulomatosis. (18309834)
2008
16
A case of proteinase 3-antineutrophil cytoplasmic antibody-positive SjAPgren's syndrome complicated with interstitial nephritis. (18084707)
2007
17
Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients. (15996251)
2005
18
Granulomatous interstitial nephritis associated with bone marrow transplantation. (15690193)
2005
19
Rabeprazole-induced acute interstitial nephritis. (15705174)
2005
20
Tubulo-interstitial nephritis and uveitis syndrome associated with mastitis: a case report. (14989453)
2004
21
Pantoprazole-induced acute interstitial nephritis. (15372423)
2004
22
Acute interstitial nephritis: clinical features and response to corticosteroid therapy. (15340098)
2004
23
A case report of tubulo-interstitial nephritis with uveitis (TINU syndrome) and follow-up for one year. (14577508)
2002-2003
24
Carbamazepine-induced acute granulomatous interstitial nephritis. (12005248)
2002
25
Acute interstitial nephritis due to nicergoline (Sermion). (12372954)
2002
26
A 57-year-old woman with gross hematuria and bilateral renal masses: an unusual presentation of acute interstitial nephritis. (11877586)
2002
27
Pyelonephritis and interstitial nephritis--clinical-pathological correlations. (12400842)
2002
28
Snakebite induced acute interstitial nephritis: report of a rare entity. (12166704)
2002
29
Acute interstitial nephritis due to omeprazole. (11774962)
2001
30
Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis. (10803769)
2000
31
Autosomal-dominant chronic interstitial nephritis with early hyperuricemia. (11068651)
2000
32
Flurithromycin-induced acute interstitial nephritis. (10783037)
2000
33
Nephrotic syndrome and acute interstitial nephritis associated with the use of diclofenac. (10444806)
1999
34
Acute interstitial nephritis with immune complex deposition and MHC class II antigen presentation along the tubular basement membrane. (10489235)
1999
35
IFN-gamma limits macrophage expansion in MRL-Fas(lpr) autoimmune interstitial nephritis: a negative regulatory pathway. (9558118)
1998
36
Indinavir and interstitial nephritis. (9471940)
1998
37
Familial interstitial nephritis and retinitis pigmentosa. (9249788)
1997
38
Acute interstitial nephritis and acute renal failure following erythromycin treatment: case report. (8816724)
1996
39
Tubulo-interstitial nephritis-uveitis (TINU)-syndrome with posterior uveitis. (9009365)
1996
40
Granulomatous interstitial nephritis secondary to allopurinol treatment. (7634557)
1995
41
Interstitial nephritis in sarcoidosis: simultaneous multiorgan involvement. (7503070)
1995
42
Nabumetone-associated interstitial nephritis. (8570441)
1995
43
Primary renal lymphoma or interstitial nephritis. (7891780)
1995
44
Acute interstitial nephritis due to omeprazole. (7934394)
1994
45
Multicentric Castleman's disease accompanied with both lymphoid interstitial pneumonia and interstitial nephritis]. (7823399)
1994
46
Immune-related potassium-losing interstitial nephritis: a comparison with distal renal tubular acidosis. (8210309)
1993
47
Interstitial nephritis in a patient receiving adoptive immunotherapy with recombinant interleukin-2 and lymphokine-activated killer cells. (1819216)
1991
48
Nephrogenic diabetes insipidus and distal tubular acidosis in methicillin-induced interstitial nephritis. (3618353)
1987
49
Renal malakoplakia. Experimental production and evidence of a link with interstitial megalocytic nephritis. (7038068)
1982
50
Interstitial Nephritis with Infantilism Accompanying Pyelitis. (19986179)
1927

Genetic Variations for Interstitial Nephritis

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Expression for genes affiliated with Interstitial Nephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Interstitial Nephritis

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Pathways for genes affiliated with Interstitial Nephritis

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49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Interstitial Nephritis

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Interstitial Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1pge24410.3MB, REN, EDN3
2aliskiren44 1111.2AGTR1, AGT, REN
3saralasin4410.2REN, AGTR1, AGT
4eprosartan44 28 1112.2REN, AGTR1, AGT
5benazepril44 1111.2AGT, AGTR1, REN
6inositol 1,4,5 trisphosphate4410.2OCRL, EDN3, HRH1
7norepinephrine44 11 2412.1HRH1, EDN3, MB
8olmesartan44 28 1112.1AGTR1, AGT, REN
9lisinopril44 11 2412.0AGTR1, REN, AGT
10diclofenac44 28 49 1113.0MB, PTGS1, HRH2, CYP2C19
11irbesartan44 28 49 1113.0PTGS1, REN, AGTR1, AGT
12candesartan44 28 1112.0AGT, AGTR1, REN, PTGS1
13captopril44 28 49 59 1114.0AGTR1, AGT, EDN3, REN
14telmisartan44 28 1112.0AGTR1, CYP2C19, AGT, REN
15diphenhydramine44 28 2 11 2414.0HRH1, CYP2C19, HRH2, PTGS1
16diltiazem44 28 1112.0AGT, AGTR1, REN, CYP2C19
17chymostatin4410.0REN, AGT, AGTR1
18deoxyribonucleic acid4410.0TIMP3, AGTR1, CT49, AGT
19lansoprazole49 44 11 2413.0ATP4A, CYP2C19, HRH2
20hydrogen44 2411.0EDN3, MB, AGTR1, CYP2C19, HRH2
21pantoprazole44 49 11 2413.0CYP2C19, ATP4A, ATP12A, HRH2
22acetaminophen44 2 49 11 2413.9AGTR1, PTGS1, HRH2, CYP2C19
23imidazole449.9MB, AGTR1, HRH1, HRH2
24atenolol44 28 49 11 2413.9REN, AGTR1, AGT
25digoxin44 49 59 11 2413.9HRH2, AGTR1, HRH1, REN
26sodium nitroprusside449.9REN, AGTR1, MB, EDN3, PTGS1
27thromboxane a244 2410.9AGT, AGTR1, PTGS1, EDN3
28valsartan44 59 28 1112.9AGTR1, AGT, REN
29losartan44 49 28 1112.8CYP2C19, REN, AGT, AGTR1
30nifedipine44 49 28 1112.8EDN3, AGTR1, AGT, CYP2C19, REN
31perindopril44 49 1111.8AGT, REN, AGTR1
32prostacyclin449.7REN, AGT, AGTR1, EDN3, PTGS1
33cgmp44 2810.7AGT, REN, AGTR1, HRH1, EDN3
34isoproterenol44 1110.6AGTR1, AGT, REN, HRH2, HRH1
35epinephrine44 11 2411.5AGTR1, AGT, MB, HRH2, HRH1, REN
36indomethacin44 59 28 1112.5REN, PTGS1, EDN3, AGT, CYP2C19, HRH1
37haloperidol44 28 2 49 1113.5CYP2C19, HRH1, REN, AGT, AGTR1, MB
38oxygen44 2410.5HRH2, CYP2C19, AGT, PTGS1, MB, TIMP3
39estradiol44 11 2411.4TIMP3, REN, CYP2C19, AGT, AGTR1, CT49
40prostaglandin449.4HRH2, EDN3, AGTR1, AGT, REN, PTGS1
41arachidonic acid44 28 11 2412.4HRH1, CYP2C19, AGT, AGTR1, EDN3, PTGS1
42vegf449.3AGT, AGTR1, REN, PTGS1, EDN3, CT49
43adenylate449.2RBP4, HRH2, HRH1, AGT, EDN3, MB
44creatinine449.2REN, MB, RBP4, OCRL, AGTR1, AGT
45dopamine44 28 11 2412.2AGTR1, CYP2C19, HRH1, REN, AGT, RBP4
46potassium44 11 2411.1EDN3, ATP12A, AGTR1, HRH1, REN, ATP4A
47nitric oxide44 11 2411.1HRH1, REN, CYP2C19, AGT, HRH2, AGTR1
48dexamethasone44 49 28 1112.0TIMP3, EDN3, RBP4, AGTR1, AGT, CYP2C19
49alanine448.9MB, EDN3, RBP4, AGTR1, HRH1, PTGS1
50lipid448.5HRH2, TIMP3, CYP2C19, RBP4, OCRL, AGTR1

GO Terms for genes affiliated with Interstitial Nephritis

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16Gene Ontology
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Cellular components related to Interstitial Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi-associated vesicleGO:00579810.0OCRL, STK16

Biological processes related to Interstitial Nephritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
3artery smooth muscle contractionGO:01482410.3EDN3, AGT
4regulation of renal sodium excretionGO:03581310.3AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
6regulation of vasoconstrictionGO:01922910.2EDN3, AGTR1, AGT
7inositol phosphate-mediated signalingGO:04801610.1HRH1, EDN3
8low-density lipoprotein particle remodelingGO:03437410.1AGT, AGTR1
9renin-angiotensin regulation of aldosterone productionGO:00201810.1REN, AGT, AGTR1
10positive regulation of cellular protein metabolic processGO:03227010.0AGTR1, AGT
11positive regulation of macrophage derived foam cell differentiationGO:01074410.0AGT, AGTR1
12visual learningGO:00854210.0HRH2, HRH1, CTNS
13phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.9AGTR1, AGT, HRH1
14kidney developmentGO:0018229.9AGTR1, AGT, REN
15angiotensin maturationGO:0020039.9AGT, REN
16regulation of cell proliferationGO:0421279.5PTGS1, AGT, AGTR1

Molecular functions related to Interstitial Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histamine receptor activityGO:00496910.0HRH2, HRH1
2acetyltransferase activator activityGO:0106989.9AGT, AGTR1
3hydrogen:potassium-exchanging ATPase activityGO:0089009.6ATP4A, ATP12A

Products for genes affiliated with Interstitial Nephritis

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Sources for Interstitial Nephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet