IDD
MCID: INT146
MIFTS: 57

Intervertebral Disc Disease (IDD) malady

Genetic diseases, Rare diseases categories

Summaries for Intervertebral Disc Disease

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44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical interventionĀ such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards: Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to degenerative disc disease and osteoporosis. An important gene associated with Intervertebral Disc Disease is COL9A2 (collagen, type IX, alpha 2), and among its related pathways are Collagen biosynthesis and modifying enzymes and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds tenidap and sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related mouse phenotypes are no phenotypic analysis and craniofacial.

Wikipedia:66 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:48 603932

Aliases & Classifications for Intervertebral Disc Disease

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44NIH Rare Diseases, 23GTR, 48OMIM, 46Novoseek, 63UMLS, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


Aliases & Descriptions:

intervertebral disc disease 44 23 48 46
intervertebral disc degeneration 44 63
intervertebral disc disorder 63
degenerative disc disease 44
idd 44


External Ids:

ICD1026 M51.3

Related Diseases for Intervertebral Disc Disease

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18GeneCards, 19GeneDecks
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Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1degenerative disc disease32.1COL9A2, COL9A3
2osteoporosis30.4IL6, IL1RN, MMP3, VDR
3pancreatitis30.2IL10, IL6, IL1B
4osteoarthritis30.1COL9A3, COL9A2, COL11A2, IL1A, IL1B, IL6
5back pain10.6
6cervicitis10.6
7spondylosis10.5
8spondylolisthesis10.4
9spinal cord injury10.3
10blindness10.3
11spondyloepiphyseal dysplasia with congenital joint dislocations10.3
12spondylolysis10.3
13hyperostosis10.3
14dengue shock syndrome10.1IL1RN
15breast cancer10.1
16cystitis10.1
17obesity10.1
18osteomyelitis10.1
19lumbar disc herniation10.1
20periapical granuloma10.1IL4
21gastric cancer risk after h. pylori infection10.1IL1RN
22hyper-igd syndrome10.1IL1RN
23schnitzler syndrome10.1IL1RN
24pulpitis10.1IL1A
25conjunctivochalasis10.1MMP3
26osteochondritis dissecans10.1COL9A2, COL9A3
27multiple epiphyseal dysplasia10.1COL9A2, COL9A3
28leprosy10.1IL2
29pleurisy10.1IL1B
30multiple epiphyseal dysplasia, dominant10.1COL9A3, COL9A2
31periodontitis10.1IL1A, IL1B
32intraocular lymphoma10.1IL10
33pseudoachondroplasia10.1COL9A3, COL9A2
34capillary leak syndrome10.1IL2
35diastrophic dysplasia10.1COL9A2, COL9A3
36stickler syndrome10.1COL9A2, COL11A2
37chronic infantile neurological cutaneous articular syndrome10.1IL1RN, IL1B
38bacterial vaginosis10.1IL1B, IL1A
39silicosis10.1IL1RN, IL1A
40blau syndrome10.1TNF, IL1B
41lumbar disc disease10.1VDR, COL9A2, COL9A3
42developmental disabilities10.1
43allergic rhinitis10.1IL4R, IL4
44gingival overgrowth10.1MMP3, IL1B, IL1A
45selective iga deficiency disease10.1IL4, IL10
46meningitis10.1IL6, IL1B
47euthyroid sick syndrome10.1IL6, IL1B
48gingivitis10.1IL1B, IL1A
49aids dementia complex10.1TNF, IL1B
50poems syndrome10.1IL6, IL1B

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to intervertebral disc disease

Symptoms for Intervertebral Disc Disease

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48OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Intervertebral Disc Disease

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intervertebral Disc Disease

Drug clinical trials:

Search ClinicalTrials for Intervertebral Disc Disease

Search NIH Clinical Center for Intervertebral Disc Disease

Search CenterWatch for Intervertebral Disc Disease

Genetic Tests for Intervertebral Disc Disease

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23GTR
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Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder23

Anatomical Context for Intervertebral Disc Disease

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34MalaCards
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MalaCards organs/tissues related to Intervertebral Disc Disease:

34
Spinal cord

Animal Models for Intervertebral Disc Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Intervertebral Disc Disease:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030127.8TNF, IFNG, IL4, IL2, IL10
2MP:00053827.5COL11A2, IL10, TNF, IL4, VDR, IFNG
3MP:00020067.2TNF, IL1B, IL6, IL10, IL1A, IL2
4MP:00053707.1IL6, IL4, IL4R, IL10, IFNG, IL2
5MP:00053887.0TNF, IL6, IL10, IL4R, IL2, IL4
6MP:00107716.8TNF, VDR, IL10, IFNG, IL4R, IL1RN
7MP:00053816.7IL6, IL4, IFNG, IL10, IL4R, VDR
8MP:00053896.7IFNG, IL4, IL2, IL1RN, VDR, IL10
9MP:00053796.7IL10, IL6, IL4R, IL2, IL4, IFNG
10MP:00053856.5TNF, VDR, IL1A, IL1RN, IL1B, IL6
11MP:00036316.5IL10, IL6, IL4R, IL4, IFNG, MMP3
12MP:00053906.4IL4, MMP3, TNF, VDR, IL1RN, IL10
13MP:00053846.2IL4, IFNG, TNF, VDR, IL4R, IL10
14MP:00053786.1COL11A2, IL10, IL4R, IL1RN, IL2, IFNG
15MP:00107685.9IFNG, IL2, IL1B, IL6, IL4R, IL1RN
16MP:00053975.6VDR, IL1A, IL1B, IL6, IL10, IL4R
17MP:00053875.6TNF, IL1A, IL1B, IL6, IL10, IL1RN
18MP:00053765.5IL10, MMP3, TNF, IFNG, VDR, IL4

Publications for Intervertebral Disc Disease

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53PubMed
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Articles related to Intervertebral Disc Disease:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. (22805224)
2013
2
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. (23702280)
2013
3
The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. (23565773)
2013
4
Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. (24381451)
2013
5
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. (22795604)
2013
6
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. (24338460)
2013
7
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. (23240963)
2013
8
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. (22912517)
2012
9
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. (22250714)
2012
10
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. (22105313)
2012
11
Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. (22286190)
2012
12
Intervertebral disc disease in dogs. (20732594)
2010
13
Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs. (20195068)
2010
14
Acupuncture treatment for feline multifocal intervertebral disc disease. (19186087)
2009
15
A critical evaluation of discography in patients with lumbar intervertebral disc disease. (18069067)
2008
16
Continuous lumbar hemilaminectomy for intervertebral disc disease in an Amur tiger (Panthera tigris altaica). (18817014)
2008
17
Future perspectives of cell-based therapy for intervertebral disc disease. (19005704)
2008
18
Re: Virtanen IM, Karppinen J, Taimela S, et al. Occupational and genetic risk factors associated with intervertebral disc disease. Spine 2007;32:1129-34. (18246021)
2007
19
Occupational and genetic risk factors associated with intervertebral disc disease. (17471097)
2007
20
Surgical decompression in dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception: A retrospective study of 46 cases. (16108215)
2005
21
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. (15733644)
2005
22
The anterior surgical approach to the cervical spine for intervertebral disc disease. (15113469)
2004
23
The role of collagen IX tryptophan polymorphisms in symptomatic intervertebral disc disease in Southern European patients. (15167667)
2004
24
Posterior surgical approach to the cervical neural foramen for intervertebral disc disease. (15028141)
2004
25
An allele of COL9A2 associated with intervertebral disc disease. (10411504)
1999
26
Cervical monosegmental interbody fusion using titanium implants in degenerative, intervertebral disc disease. (10228933)
1999
27
Spinal cord swelling as a myelographic indicator of prognosis: a retrospective study in dogs with intervertebral disc disease and loss of deep pain perception. (8719081)
1996
28
Microsurgical management of the lumbar intervertebral disc-disease. (8570065)
1995
29
Biomechanical, radiologic, and histopathologic correlations in the pathogenesis of experimental intervertebral disc disease. (7809747)
1994
30
Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease. (8488675)
1993
31
Intervertebral disc disease. (1641922)
1992
32
Lumbar intervertebral disc disease in the pediatric population. (1476937)
1992
33
Surgical treatments for intervertebral disc disease. (1641923)
1992
34
Surgical management of lumbar intervertebral-disc disease. (2674153)
1989
35
Intraoperative problems associated with intervertebral disc disease. (2520125)
1989
36
Neuroanatomic and pathophysiologic aspects of intervertebral disc disease in the dog. (2520119)
1989
37
Canine intervertebral disc disease: a review of etiologic and predisposing factors. (6755879)
1982
38
Clinical aspects of lumbar intervertebral disc disease. (7217799)
1981
39
Canine cervical intervertebral disc disease. (551206)
1979
40
New knowledge of intervertebral disc disease. (365890)
1978
41
Chymopapain treatment of intervertebral disc disease. (123575)
1975
42
Regional use of steroids in the management of lumbar intervertebral disc disease. (1113969)
1975
43
The surgical approach to canine intervertebral disc disease. (4795128)
1973
44
Recent advances in the diagnosis of intervertebral disc disease. (4723646)
1973
45
Lumbar intervertebral disc disease in the elderly. (4239509)
1969
46
Lumbar intervertebral disc disease in Africans. (6018777)
1967
47
Conservative treatment of thoracolumbar intervertebral disc disease in the dog. (5884038)
1965
48
Review of the present position in spinal intervertebral disc disease. (13878294)
1962
49
The lumbar intervertebral disc disease syndrome; clinical correlation of one hundred and seventy-five cases. (13268013)
1955
50
Intervertebral disc disease; its recognition and treatment by the general practitioner. (18864529)
1948

Variations for Intervertebral Disc Disease

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65UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

65
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Intervertebral Disc Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for genes affiliated with Intervertebral Disc Disease

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 55R&D Systems, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters
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Pathways related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4MMP3, COL9A3, COL11A2, COL9A2
28.9IL6, IL4, IL4R, IL1B
38.8IL1B, TNF, MMP3, IL6
48.6IL1B, IFNG, TNF, IL1A
5
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.5IFNG, IL4, IL1B, IL2
68.5IL1B, IL1A, IFNG, IL6
7
Show member pathways
8.5IL6, IL1B, IL1A, IFNG
88.5IFNG, IL4, IL4R, IL2
9
Show member pathways
8.4IL1B, IL2, IL1RN, IL6, IL1A
10
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.4TNF, IL1RN, IL6, IL1A, IL1B
118.4COL11A2, IL6, IL4R, IL2, IL4
128.3IL1A, IL1B, IL10, TNF, IL6
138.3IL1B, IL1A, IL6, IL10, TNF
148.3IFNG, IL2, IL4, IL10
15
Show member pathways
8.3IL1A, TNF, IL2, IL6, IL1B
16
Show member pathways
thioredoxin pathway39
8.3IL1B, TNF, IFNG, IL6
17
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.2IFNG, TNF, IL4, IL2
18
Show member pathways
8.2TNF, IL2, IFNG, IL10
19
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.2TNF, IL2, IL4, IL4R, IL6
208.1IL6, IL2, IL4, IFNG
21
Show member pathways
8.1IL4, IL4R, IL6, IFNG, IL1B
228.1TNF, IL4, IL4R, IL6, IL1B, IL1A
238.0TNF, IFNG, IL2, IL6
248.0IL1RN, IL6, IL1B, IL10, TNF, IL1A
25
Show member pathways
Immune response MIF in innate immunity response61
8.0IFNG, IL6, IL1B, TNF, IL1A
267.8IL1B, IL6, IFNG, TNF, IL10
277.8TNF, IL10, IL6, IL1B, IFNG
287.6IL6, IL1B, MMP3, TNF, IFNG, IL1A
29
Show member pathways
7.6IFNG, IL2, IL1RN, IL6, IL1A, IL1B
30
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
7.6TNF, IFNG, IL6, IL1B, IL1A, IL4
317.5VDR, IL1B, TNF, IFNG, IL6, IL1A
327.5TNF, IL10, IFNG, COL11A2, IL1B, IL6
33
Show member pathways
7.4IL4R, IL2, IFNG, TNF, IL1B, IL4
34
Show member pathways
Type III interferon signaling39
7.4IL6, IL10, IL4R, IL2, IL4, IFNG
35
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
7.3IFNG, TNF, IL2, IL10, IL1B, IL6
36
Show member pathways
IL27-mediated signaling events39
7.3IL1B, IL6, IL10, IL2, IFNG, TNF
37
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
7.3IL1B, IL2, IL10, IFNG, IL6, TNF
38
Show member pathways
7.1TNF, IL1A, IL6, IL10, IL4R, IL2
39
Show member pathways
7.1IL10, TNF, IL4, IL1A, IL1B, IL6
407.1IL1B, TNF, VDR, IFNG, IL10, IL6
41
Show member pathways
7.1TNF, IL4, IL2, IL1B, IL1A, IL6
427.1IFNG, IL1A, IL1B, IL6, IL2, TNF
43
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
6.6IL1A, IL1B, IL10, IL6, IL2, IL4
446.6TNF, IL1B, IL6, IL1A, IL10, IL2
456.6IL4, IFNG, IL2, IL10, IL6, IL1B
46
Show member pathways
6.4IL2, IL10, COL9A3, COL9A2, COL11A2, IL1A
47
Show member pathways
6.3IL2, IL10, TNF, IFNG, IL1B, IL4
48
Show member pathways
6.3IL10, IL1B, IL6, IL4R, IL2, IL4
49
Show member pathways
6.3IL1B, IL1A, IL4, IFNG, TNF, IL4R
50
Show member pathways
6.3IL4, IL2, IL4R, IL10, IL6, IFNG

Compounds for genes affiliated with Intervertebral Disc Disease

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 202)
idCompoundScoreTop Affiliating Genes
1tenidap46 309.8TNF, IL1A, IL1B, IL6
2sulfasalazine30 46 52 1211.7IL1RN, TNF, MMP3, IL1B, IL1A
3toxin-1468.7IL1B, IL1RN, IL2, TNF, IL10
4leflunomide46 52 1210.6IL1RN, TNF, IL6, MMP3, IL1B
5mip 1alpha468.6IL1B, TNF, IL4, IL10, IL6
6groalpha468.4IL1A, IL1B, IL6, TNF, IL10
7lipoteichoic acid468.3TNF, IL1RN, IL10, IL6, IL1B
8bucillamine468.2IFNG, IL2, IL1B, IL6
9interferon gamma468.2IFNG, IL4, IL2, TNF, IL10
10gold sodium thiomalate468.1IL1RN, TNF, IFNG, IL2, IL1B, IL1A
11taurine chloramine468.1TNF, IFNG, IL2, IL6, IL1B
12tarc468.0IFNG, TNF, IL4R, IL1A, IL10, IL4
13imiquimod46 62 30 1210.9IL6, IL10, TNF, IFNG, IL1A
14pdtc467.8IFNG, IL1A, IL6, IL4, TNF, IL1B
15ccl346 308.8IL10, IL1A, IL1B, TNF, IFNG, IL6
16adalimumab46 52 129.8IFNG, IL10, TNF, IL6, MMP3, IL1RN
17triptolide467.8IL1B, IL6, IL2, MMP3, TNF, IFNG
1815-deoxy-delta-12,14-prostaglandin j2467.7IL1B, IL6, IL10, IFNG, TNF, IL4
19etanercept46 52 129.5TNF, MMP3, IFNG, IL1RN, IL10, IL6
20okt3467.5IL2, IL6, IL10, IFNG, TNF, IL4
21ionomycin467.5IL2, IL4, IFNG, TNF, IL4R, IL10
22endotoxin467.4IFNG, IL1RN, IL10, TNF, IL1B, IL1A
23herbimycin a46 628.4IL4, IFNG, IL1B, TNF, IL1A, IL6
24thalidomide46 52 62 1210.3IL1B, IFNG, TNF, IL1A, IL6, IL10
25il-12467.3IL2, IL10, IL6, IL1B, IL4, IFNG
26rantes467.2IL1A, IL1B, MMP3, IFNG, IL4, IL2
272,5-oligoadenylate467.2IFNG, IL2, TNF, IL6, IL10
28polymyxin b467.2IL1A, IL1B, TNF, IFNG, IL4, IL1RN
29ivig467.2TNF, IFNG, IL4, IL1RN, IL10, IL6
30infliximab46 52 129.2TNF, MMP3, IFNG, IL1RN, IL1B, IL6
31prednisolone46 30 129.2IFNG, IL6, IL10, TNF, IL1RN, MMP3
32simvastatin46 52 62 30 25 1212.1IL1A, IL1RN, IL10, IL6, IFNG, MMP3
33gm-csf46 308.0TNF, IFNG, IL4, IL2, IL10, IL6
34polyinosinic-polycytidylic acid467.0TNF, IFNG, IL4, IL2, IL10, IL6
35genistein46 30 62 3 25 1211.9IL1B, IL1A, TNF, IL6, IL2, IFNG
36indomethacin46 30 62 129.8TNF, MMP3, IFNG, IL4, IL2, IL1RN
37actinomycin d466.7IFNG, VDR, IL6, IL1B, IL4R, IL2
38neopterin466.7IL6, IL1B, IL1A, IL10, IL1RN, TNF
39pentoxifylline46 127.7TNF, IFNG, IL4, IL2, IL1RN, IL10
40hydrocortisone46 3 62 129.6IL1B, IL1A, IL6, IL10, IL1RN, IL2
41calcitriol46 62 25 129.6VDR, TNF, IFNG, IL4, IL1A, IL1B
42sb 20358046 627.5IFNG, IL4, IL10, IL6, IL1B, IL1A
43histamine46 30 258.4TNF, MMP3, IFNG, IL4, IL2, IL1RN
44thymidine46 257.3IL1A, IL1B, IL6, IL10, IL4R, IL2
45vegf466.3IL4, IL2, IL1B, IL1A, IL1RN, IL10
46il 10466.0IL4, IL2, IL1RN, IL4R, IL10, IL6
47cyclosporin a46 30 627.9VDR, TNF, MMP3, IFNG, IL4, IL2
48pge2465.9VDR, TNF, MMP3, IFNG, IL4, IL2
49cycloheximide465.6VDR, TNF, MMP3, IFNG, IL4, IL2
50dexamethasone46 52 30 128.6IL6, IL1B, IL1A, IL10, IL4R, TNF

GO Terms for genes affiliated with Intervertebral Disc Disease

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17Gene Ontology
See all sources

Cellular components related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.7COL9A3, COL9A2, COL11A2
2collagen type IXGO:0055949.7COL9A3, COL9A2
3external side of plasma membraneGO:0098978.0TNF, IFNG, IL4, IL6
4extracellular regionGO:0055766.4IL2, IFNG, MMP3, TNF, IL6, IL1B
5extracellular spaceGO:0056155.7IL1A, TNF, MMP3, IFNG, IL4, IL2

Biological processes related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:00178110.2IL6
2ectopic germ cell programmed cell deathGO:03523410.1IL1B, IL1A
3sequestering of triglycerideGO:03073010.0IL1B, TNF
4fever generationGO:00166010.0IL1RN, IL1B, IL1A
5regulation of isotype switchingGO:04519110.0IL10, IL4
6chronic inflammatory response to antigenic stimulusGO:00243910.0IL1RN, TNF
7positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
8type 2 immune responseGO:0420929.9IL10, IL4
9positive regulation of fever generationGO:0316229.9IL1B, TNF
10positive regulation of interleukin-2 biosynthetic processGO:0450869.9IL1A, IL1B
11receptor biosynthetic processGO:0328009.8TNF, IL10
12collagen catabolic processGO:0305749.8COL9A3, COL9A2, COL11A2, MMP3
13extracellular matrix disassemblyGO:0226179.8COL9A3, COL9A2, COL11A2, MMP3
14positive regulation of T-helper 2 cell differentiationGO:0456309.8IL4R, IL6
15positive regulation of mitosisGO:0458409.8IL1B, TNF, IL1A
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1A, IL1B, TNF
17negative regulation of cytokine secretion involved in immune responseGO:0027409.8IL10, TNF
18regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.6TNF, IL1B
19positive regulation of cytokine secretionGO:0507159.6IL1A, TNF, IL10
20positive regulation of interferon-gamma productionGO:0327299.5TNF, IL2, IL1B
21negative regulation of lipid storageGO:0108889.5TNF, IL6
22positive regulation of interleukin-6 biosynthetic processGO:0454109.5IL1B, IFNG
23epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.5TNF, IL6
24positive regulation of vitamin D biosynthetic processGO:0605579.5TNF, IFNG
25extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5IL1B, IL2, IL4, IL1A
26positive regulation of interleukin-6 productionGO:0327559.4IL1B, IL6, TNF
27positive regulation of immunoglobulin secretionGO:0510249.4IL6, IL2
28negative regulation of nitric oxide biosynthetic processGO:0450199.3IL10, IL4
29positive regulation of calcidiol 1-monooxygenase activityGO:0605599.3TNF, IL1B, IFNG
30extracellular matrix organizationGO:0301989.3MMP3, TNF, COL11A2, COL9A2, COL9A3
31positive regulation of membrane protein ectodomain proteolysisGO:0510449.3TNF, IL1B, IFNG
32positive regulation of MHC class II biosynthetic processGO:0453489.2IL10, IFNG, IL4
33positive regulation of isotype switching to IgG isotypesGO:0483049.2IL2, IL4, IFNG
34negative regulation of growth of symbiont in hostGO:0441309.1IL10, IFNG, TNF
35positive regulation of chemokine biosynthetic processGO:0450809.0TNF, IFNG, IL4, IL1B
36response to glucocorticoidGO:0513848.9IL10, IL6, IL1RN, TNF
37regulation of insulin secretionGO:0507968.9IL1B, IFNG, TNF
38positive regulation of T cell proliferationGO:0421028.8IL1B, IL6, IL4, IFNG
39immune responseGO:0069558.8IL2, IL1RN, IL4R, IL1B, IL1A, IL4
40defense response to protozoanGO:0428328.8IFNG, IL6, IL4R, IL4
41humoral immune responseGO:0069598.8IFNG, IL6, TNF
42cytokine-mediated signaling pathwayGO:0192218.8IL6, IL1B, IFNG, IL1A
43negative regulation of cell proliferationGO:0082858.7TNF, VDR, IL6, IL1B, IL1A
44inflammatory responseGO:0069548.7IL1B, TNF, IL6, IL10, IL1A
45positive regulation of nitric oxide biosynthetic processGO:0454298.7IL6, IFNG, TNF, IL1B
46positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.7IL1B, IL6, IL4, IL10, TNF
47positive regulation of transcription, DNA-templatedGO:0458938.6IL10, TNF, IL1B, IL4, IL6
48negative regulation of apoptotic processGO:0430668.5IL6, IL2, IL4, IL1RN, IL10
49response to drugGO:0424937.8IL10, IL4, IFNG, IL6, TNF, IL1RN
50positive regulation of transcription from RNA polymerase II promoterGO:0459446.6IL1A, VDR, TNF, IFNG, IL2, IL10

Molecular functions related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.6COL11A2, COL9A2, COL9A3
2interleukin-1 receptor bindingGO:0051499.3IL1A, IL1B, IL1RN
3growth factor activityGO:0080838.5IL6, IL10, IL2, IL4
4cytokine activityGO:0051256.6IL1A, IL1B, IL6, IL10, IL2, IL4

Products for genes affiliated with Intervertebral Disc Disease

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Intervertebral Disc Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet