MCID: INT146
MIFTS: 55

Intervertebral Disc Disease malady

Genetic diseases, Rare diseases categories

Aliases & Classifications for Intervertebral Disc Disease

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Sources:
46OMIM, 9diseasecard, 42NIH Rare Diseases, 44Novoseek, 22GTR, 61UMLS, 25ICD10
See all sources

Aliases & Descriptions for Intervertebral Disc Disease:

Name: Intervertebral Disc Disease 46 42 44
Lumbar Disc Disease 46 44 61
Intervertebral Disc Disease, Susceptibility to 9 22
Intervertebral Disc Degeneration 42 61
Degeneration of Lumbar Intervertebral Disc 61
 
Intervertebral Disc Disorder 61
Degenerative Disc Disease 42
Lumbar Disc Degeneration 46
Lumbar Disc Herniation 46
Idd 42


Classifications:



External Ids:

OMIM46 603932
ICD1025 M51.3, M51.8

Summaries for Intervertebral Disc Disease

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NIH Rare Diseases:42 Intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards based summary: Intervertebral Disc Disease, also known as lumbar disc disease, is related to degenerative disc disease and osteoporosis. An important gene associated with Intervertebral Disc Disease is COL9A2 (collagen, type IX, alpha 2), and among its related pathways are Protein digestion and absorption and Collagen biosynthesis and modifying enzymes. The compounds toxin-1 and sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related mouse phenotypes are limbs/digits/tail and craniofacial.

OMIM:46 Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common... (603932) more...

Related Diseases for Intervertebral Disc Disease

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Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1degenerative disc disease31.3COL9A3
2osteoporosis30.6IL1RN, MMP3, VDR, IL6
3pancreatitis30.6IL1B, IL10, IL6
4arthritis30.4IL1A, TNF, IL1B, MMP3, IL6
5atherosclerosis30.0MMP3, IL10, IL6, IL1RN, TNF, IL1A
6osteoarthritis28.9COL9A3, CILP, MMP3, ASPN, IL1RN, IL4R
7rheumatoid arthritis28.7IL1A, TNF, MMP3, IL1B, IL6, IL10
8cauda equina syndrome10.9
9back pain10.8
10radiculopathy10.8
11spinal stenosis10.7
12cervicitis10.6
13periapical granuloma10.6IL4
14dengue shock syndrome10.6IL1RN
15leprosy10.5IL2
16gastric cancer risk after h. pylori infection10.5IL1RN
17hyper-igd syndrome10.5IL1RN
18multiple epiphyseal dysplasia10.5COL9A2, COL9A3
19alkaptonuria10.5
20obesity10.5
21chronic pain10.5
22schnitzler syndrome10.5IL1RN
23osteochondritis dissecans10.5COL9A3, COL9A2
24conjunctivochalasis10.5MMP3
25spondylolisthesis10.5
26pulpitis10.5IL1A
27periodontitis10.5IL1A, IL1B
28multiple epiphyseal dysplasia, dominant10.5COL9A2, COL9A3
29capillary leak syndrome10.5IL2
30intraocular lymphoma10.5IL10
31hemangioma10.4
32spondylolysis10.4
33arachnoiditis10.4
34cinca syndrome10.4IL1B, IL1RN
35pseudoachondroplasia10.4COL9A2, COL9A3
36fibrochondrogenesis10.4COL11A1
37silicosis10.4IL1RN, IL1A
38euthyroid sick syndrome10.4IL6, IL1B
39pleurisy10.4IL1B
40meningitis10.4IL1B, IL6
41blau syndrome10.4TNF, IL1B
42selective iga deficiency disease10.4IL10, IL4
43diastrophic dysplasia10.4COL9A2, COL9A3
44gingival overgrowth10.4IL1B, IL1A, MMP3
45bacterial vaginosis10.4IL1A, IL1B
46poems syndrome10.4IL1B, IL6
47cutaneous leishmaniasis10.3IL10, IFNG
48agammaglobulinemia10.3IL2, IL4
49spinal cord injury10.3
50blindness10.3

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to intervertebral disc disease

Symptoms for Intervertebral Disc Disease

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Clinical features from OMIM:

603932

Drugs & Therapeutics for Intervertebral Disc Disease

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Drug clinical trials:

Search ClinicalTrials for Intervertebral Disc Disease

Search NIH Clinical Center for Intervertebral Disc Disease

Genetic Tests for Intervertebral Disc Disease

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Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder22

Anatomical Context for Intervertebral Disc Disease

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MalaCards organs/tissues related to Intervertebral Disc Disease:

31
Spinal cord

Animal Models for Intervertebral Disc Disease or affiliated genes

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Publications for Intervertebral Disc Disease

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Articles related to Intervertebral Disc Disease:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. (25694233)
2015
2
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications. (25523328)
2014
3
Lack of relationship between occupational workload and microscopic alterations in lumbar intervertebral disc disease. (25136392)
2014
4
Neurologic outcome after thoracolumbar partial lateral corpectomy for intervertebral disc disease in 72 dogs. (24484371)
2014
5
Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. (22805224)
2013
6
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. (23702280)
2013
7
The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. (23565773)
2013
8
Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. (24381451)
2013
9
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. (22795604)
2013
10
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. (24338460)
2013
11
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. (23240963)
2013
12
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. (22912517)
2012
13
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. (22250714)
2012
14
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. (22105313)
2012
15
Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. (22286190)
2012
16
Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs. (20195068)
2010
17
Acupuncture treatment for feline multifocal intervertebral disc disease. (19186087)
2009
18
A critical evaluation of discography in patients with lumbar intervertebral disc disease. (18069067)
2008
19
Continuous lumbar hemilaminectomy for intervertebral disc disease in an Amur tiger (Panthera tigris altaica). (18817014)
2008
20
Future perspectives of cell-based therapy for intervertebral disc disease. (19005704)
2008
21
Re: Virtanen IM, Karppinen J, Taimela S, et al. Occupational and genetic risk factors associated with intervertebral disc disease. Spine 2007;32:1129-34. (18246021)
2007
22
Surgical decompression in dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception: A retrospective study of 46 cases. (16108215)
2005
23
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. (15733644)
2005
24
The anterior surgical approach to the cervical spine for intervertebral disc disease. (15113469)
2004
25
The role of collagen IX tryptophan polymorphisms in symptomatic intervertebral disc disease in Southern European patients. (15167667)
2004
26
Posterior surgical approach to the cervical neural foramen for intervertebral disc disease. (15028141)
2004
27
An allele of COL9A2 associated with intervertebral disc disease. (10411504)
1999
28
Cervical monosegmental interbody fusion using titanium implants in degenerative, intervertebral disc disease. (10228933)
1999
29
Spinal cord swelling as a myelographic indicator of prognosis: a retrospective study in dogs with intervertebral disc disease and loss of deep pain perception. (8719081)
1996
30
Microsurgical management of the lumbar intervertebral disc-disease. (8570065)
1995
31
Biomechanical, radiologic, and histopathologic correlations in the pathogenesis of experimental intervertebral disc disease. (7809747)
1994
32
Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease. (8488675)
1993
33
Intervertebral disc disease. (1641922)
1992
34
Lumbar intervertebral disc disease in the pediatric population. (1476937)
1992
35
Surgical treatments for intervertebral disc disease. (1641923)
1992
36
Surgical management of lumbar intervertebral-disc disease. (2674153)
1989
37
Intraoperative problems associated with intervertebral disc disease. (2520125)
1989
38
Neuroanatomic and pathophysiologic aspects of intervertebral disc disease in the dog. (2520119)
1989
39
Canine intervertebral disc disease: a review of etiologic and predisposing factors. (6755879)
1982
40
Clinical aspects of lumbar intervertebral disc disease. (7217799)
1981
41
Canine cervical intervertebral disc disease. (551206)
1979
42
New knowledge of intervertebral disc disease. (365890)
1978
43
Chymopapain treatment of intervertebral disc disease. (123575)
1975
44
The surgical approach to canine intervertebral disc disease. (4795128)
1973
45
Recent advances in the diagnosis of intervertebral disc disease. (4723646)
1973
46
Lumbar intervertebral disc disease in the elderly. (4239509)
1969
47
Lumbar intervertebral disc disease in Africans. (6018777)
1967
48
Conservative treatment of thoracolumbar intervertebral disc disease in the dog. (5884038)
1965
49
Review of the present position in spinal intervertebral disc disease. (13878294)
1962
50
The lumbar intervertebral disc disease syndrome; clinical correlation of one hundred and seventy-five cases. (13268013)
1955

Variations for Intervertebral Disc Disease

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UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

63
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Intervertebral Disc Disease

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Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for genes affiliated with Intervertebral Disc Disease

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Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6COL9A2, COL11A1, COL9A3, COL11A2
2
Show member pathways
9.3COL11A2, COL9A2, COL11A1, MMP3, COL9A3
3
Show member pathways
9.1COL9A3, ASPN, COL11A2, COL9A2, MMP3, COL11A1
48.9IL4, IL6, IL1B, IL4R
5
Show member pathways
Immune response IL 12 induced IFN gamma production59
8.5IL2, IL4, IL1B, IFNG
68.5IFNG, IL6, IL1B, IL1A
78.5IFNG, IL4, IL2, IL4R
8
Show member pathways
8.5COL9A2, COL11A1, COL11A2, IL6, COL9A3, IL2
9
Show member pathways
8.4IL6, IL1A, IL1B, IL2, IL1RN
10
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.4IL1A, TNF, IL1RN, IL6, IL1B
118.3IL1B, TNF, IL10, IL6, IL1A
128.3IL6, IL1A, IL1B, TNF, IL10
138.3IL10, IL4, IFNG, IL2
14
Show member pathways
8.3IL1A, IL1B, IL6, IL2, TNF
15
Show member pathways
thioredoxin pathway36
8.3TNF, IFNG, IL1B, IL6
16
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.2IL4, IL2, TNF, IFNG
17
Show member pathways
8.2IL2, TNF, IL10, IFNG
18
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
8.2IL2, IL6, IL4R, IL4, TNF
198.1IL6, IL2, IL4, IFNG
20
Show member pathways
8.1IL1B, IL6, IL4R, IL4, IFNG
218.1IL4R, IL1A, TNF, IL6, IL1B, IL4
228.0IFNG, TNF, IL6, IL2
238.0IL1B, IL10, IL1RN, TNF, IL6, IL1A
248.0THBS2, IL4, COL11A2, IL6, COL11A1, IL4R
25
Show member pathways
Immune response MIF in innate immunity response59
8.0IFNG, IL1A, IL6, IL1B, TNF
267.8IL1B, IL10, TNF, IL6, IFNG
277.6TNF, IL1B, IFNG, MMP3, IL1A, IL6
28
Show member pathways
7.6IFNG, IL2, IL1RN, IL6, IL1B, IL1A
29
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
7.6IL1A, TNF, IFNG, IL6, IL4, IL1B
307.6IL10, TNF, THBS2, IFNG, IL1B, IL6
317.5VDR, IL1B, IL6, IL1A, TNF, IFNG
32
Show member pathways
7.4IL2, IL4, IL4R, IL1B, IL1A, TNF
33
Show member pathways
Type III interferon signaling36
7.4IL10, IL6, IL4R, IL2, IL4, IFNG
347.3COL11A1, IL6, COL11A2, TNF, IFNG, IL10
35
Show member pathways
IL27-mediated signaling events36
7.3IL10, IL6, IL1B, IL2, IFNG, TNF
36
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.3IL6, IFNG, TNF, IL2, IL1B, IL10
37
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
7.3IL10, IL6, IL1B, TNF, IFNG, IL2
38
Show member pathways
7.1TNF, IL2, IL1A, IL4, IL4R, IL1B
39
Show member pathways
7.1IL4, IL6, IL1A, IL1B, TNF, IL2
407.1IL10, IL1B, IL1A, IL6, IFNG, TNF
41
Show member pathways
7.1IFNG, TNF, IL4, IL2, IL6, IL1A
427.1IL6, IL2, IL4, TNF, IFNG, IL1A
436.6TNF, IFNG, IL4, IL2, IL10, IL6
446.6IL6, IL1A, IL10, IL1B, IL2, IL4
45
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
6.6IFNG, IL4, IL2, IL10, IL6, IL1B
46
Show member pathways
6.3IL1B, IL1A, IFNG, IL6, IL2, TNF
47
Show member pathways
6.3IL4R, IL1A, TNF, IL10, IFNG, IL4
48
Show member pathways
6.3IFNG, IL2, IL4R, IL10, IL6, IL1B
49
Show member pathways
6.3IL4, IL6, IL10, IL1B, IFNG, TNF
50
Show member pathways
6.3COL9A3, IL2, IL4R, IL6, IL4, IL1B

Compounds for genes affiliated with Intervertebral Disc Disease

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Compounds related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idCompoundScoreTop Affiliating Genes
1toxin-1448.7IL1RN, IL1B, IL10, TNF, IL2
2sulfasalazine28 44 50 1111.6TNF, IL1A, IL1RN, MMP3, IL1B
3mip 1alpha448.6IL1B, IL6, IL10, IL4, TNF
4leflunomide44 50 1110.5IL6, IL1RN, MMP3, IL1B, TNF
5groalpha448.4IL1A, IL1B, IL6, IL10, TNF
6lipoteichoic acid448.3IL1RN, IL1B, TNF, IL10, IL6
7interferon gamma448.2IL2, IL4, IFNG, IL10, TNF
8gold sodium thiomalate448.1IL1A, IL1RN, IL2, IFNG, TNF, IL1B
9taurine chloramine448.1IL1B, IL6, TNF, IL2, IFNG
10tarc448.0IL4R, IL1A, IL10, IL4, IFNG, TNF
11tgf beta1448.0THBS2, MMP3, TNF, IL6, IL1B, IL10
12bucillamine448.0IFNG, IL1B, IL6, IL2
13imiquimod44 60 28 1111.0IL1A, IL6, IL10, IFNG, TNF
14ccl344 288.8IFNG, IL1A, IL1B, IL6, IL10, TNF
15adalimumab44 50 119.8MMP3, IFNG, TNF, IL10, IL6, IL1RN
16triptolide447.8IL2, IFNG, IL6, MMP3, IL1B, TNF
17pdtc447.8IL1A, TNF, IFNG, IL4, IL1B, IL6
1815-deoxy-delta-12,14-prostaglandin j2447.6IL4, IL1B, IL6, IFNG, TNF, IL10
192,5-oligoadenylate447.5IL10, IL6, IFNG, TNF, IL2
20etanercept44 50 119.5IFNG, IL1B, IL6, IL10, MMP3, TNF
21okt3447.5IFNG, IL6, TNF, IL2, IL10, IL4
22ionomycin447.4IL4R, IL2, IL10, IL1A, IFNG, TNF
23endotoxin447.4IL1A, IL1RN, IL1B, IL6, IL10, IFNG
24thalidomide44 50 60 1110.3IL6, IL2, IL10, IFNG, TNF, IL1A
25herbimycin a44 608.3IFNG, IL4, IL2, IL6, IL1B, IL1A
26il-12447.3IFNG, IL1B, IL6, IL10, IL2, IL4
27rantes447.2IL1B, IL1A, IL10, MMP3, IFNG, IL4
28ivig447.2IL1B, IL6, IFNG, TNF, IL1A, IL4
29polymyxin b447.2IL10, IL1RN, IL1A, IL1B, IL6, IL4
30infliximab44 50 119.2TNF, MMP3, IFNG, IL4, IL1RN, IL10
31prednisolone44 28 119.2IFNG, TNF, MMP3, IL2, IL1RN, IL6
32simvastatin44 50 60 28 24 1112.1IFNG, IL1RN, IL10, IL4, MMP3, TNF
33polyinosinic-polycytidylic acid447.0IFNG, TNF, IL10, IL2, IL4, IL1A
34gm-csf44 288.0IL1A, IL1B, IL6, IL10, IL2, IL4
35genistein44 28 60 1 24 1111.9MMP3, TNF, IFNG, IL2, IL6, IL1B
36indomethacin44 28 60 119.8IL1RN, IL6, TNF, MMP3, IFNG, IL1A
37actinomycin d446.7IL1A, IL4, IL4R, IL6, VDR, TNF
38hydrocortisone44 1 60 119.7TNF, IFNG, IL4, IL2, IL1RN, IL10
39pentoxifylline44 117.7IL10, IL1RN, IL6, IL1B, IL1A, IL2
40neopterin446.7IL4, IL2, IL1RN, IL10, IL6, IL1B
41calcitriol44 60 24 119.6IL4, TNF, IFNG, VDR, IL2, IL10
42sb 20358044 607.5VDR, TNF, MMP3, IFNG, IL4, IL1RN
43histamine44 28 248.4TNF, MMP3, IFNG, IL4, IL2, IL1RN
44thymidine44 247.1IL4, IL2, IL4R, IL10, IL6, IL1B
45vegf446.1IL4, IL2, IFNG, IL1A, MMP3, TNF
46il 10446.0IFNG, TNF, VDR, IL6, IL4R, IL1RN
47cyclosporin a44 28 607.9IL10, IL6, IL1A, IL4R, IL1RN, VDR
48pge2445.9IL1RN, IL1A, IL1B, IL6, IL10, IFNG
49cycloheximide445.7IL1A, VDR, MMP3, TNF, IFNG, IL1B
50dexamethasone44 50 28 118.7VDR, IL1A, IL1B, IL6, TNF, MMP3

GO Terms for genes affiliated with Intervertebral Disc Disease

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Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen type XIGO:000559210.0COL11A1, COL11A2
2collagen type IXGO:000559410.0COL9A2, COL9A3
3endoplasmic reticulum lumenGO:00057889.3COL9A3, COL11A1, COL9A2, COL11A2
4external side of plasma membraneGO:00098978.1IL6, IL4, IFNG, TNF
5extracellular regionGO:00055766.1IL2, IFNG, MMP3, TNF, THBS2, IL6
6extracellular spaceGO:00056155.5IL1A, TNF, CILP, MMP3, IFNG, IL4

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:000178110.2IL6
2ectopic germ cell programmed cell deathGO:003523410.1IL1B, IL1A
3sequestering of triglycerideGO:003073010.0TNF, IL1B
4fever generationGO:000166010.0IL1A, IL1B, IL1RN
5regulation of isotype switchingGO:004519110.0IL4, IL10
6chronic inflammatory response to antigenic stimulusGO:000243910.0IL1RN, TNF
7positive regulation of heterotypic cell-cell adhesionGO:003411610.0IL1B, TNF
8type 2 immune responseGO:004209210.0IL10, IL4
9positive regulation of fever generationGO:003162210.0IL1B, TNF
10positive regulation of interleukin-2 biosynthetic processGO:00450869.9IL1B, IL1A
11receptor biosynthetic processGO:00328009.8TNF, IL10
12positive regulation of T-helper 2 cell differentiationGO:00456309.8IL6, IL4R
13positive regulation of mitosisGO:00458409.8IL1A, IL1B, TNF
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.8IL1B, IL1A, TNF
15negative regulation of cytokine secretion involved in immune responseGO:00027409.8IL10, TNF
16collagen catabolic processGO:00305749.7MMP3, COL9A3, COL11A1, COL9A2, COL11A2
17extracellular matrix disassemblyGO:00226179.7MMP3, COL11A2, COL9A2, COL11A1, COL9A3
18regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.6TNF, IL1B
19positive regulation of cytokine secretionGO:00507159.6TNF, IL10, IL1A
20positive regulation of interferon-gamma productionGO:00327299.5IL1B, TNF, IL2
21epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.5IL6, TNF
22positive regulation of immunoglobulin secretionGO:00510249.5IL2, IL6
23positive regulation of vitamin D biosynthetic processGO:00605579.5TNF, IFNG
24positive regulation of interleukin-6 biosynthetic processGO:00454109.5IL1B, IFNG
25extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.5IL4, IL2, IL1B, IL1A
26negative regulation of lipid storageGO:00108889.4IL6, TNF
27positive regulation of interleukin-6 productionGO:00327559.4IL1B, IL6, TNF
28negative regulation of nitric oxide biosynthetic processGO:00450199.3IL10, IL4
29positive regulation of calcidiol 1-monooxygenase activityGO:00605599.3TNF, IL1B, IFNG
30positive regulation of membrane protein ectodomain proteolysisGO:00510449.3IFNG, TNF, IL1B
31positive regulation of MHC class II biosynthetic processGO:00453489.2IL10, IL4, IFNG
32positive regulation of isotype switching to IgG isotypesGO:00483049.2IL2, IL4, IFNG
33extracellular matrix organizationGO:00301989.2COL9A2, COL9A3, COL11A1, TNF, MMP3, COL11A2
34negative regulation of growth of symbiont in hostGO:00441309.1IL10, TNF, IFNG
35positive regulation of chemokine biosynthetic processGO:00450809.0IFNG, IL4, IL1B, TNF
36response to glucocorticoidGO:00513848.9IL6, IL10, TNF, IL1RN
37regulation of insulin secretionGO:00507968.9IFNG, TNF, IL1B
38defense response to protozoanGO:00428328.8IL4R, IL4, IFNG, IL6
39positive regulation of T cell proliferationGO:00421028.8IFNG, IL4, IL1B, IL6
40immune responseGO:00069558.8IL1A, IL1RN, IL2, IL4, IL4R, IL1B
41humoral immune responseGO:00069598.8IFNG, IL6, TNF
42negative regulation of cell proliferationGO:00082858.7IL1A, IL1B, IL6, TNF, VDR
43cytokine-mediated signaling pathwayGO:00192218.7IL1A, IFNG, IL1B, IL6
44inflammatory responseGO:00069548.7TNF, IL1A, IL1B, IL10, IL6
45positive regulation of nitric oxide biosynthetic processGO:00454298.7IL1B, TNF, IFNG, IL6
46positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.7IL10, TNF, IL4, IL6, IL1B
47positive regulation of transcription, DNA-templatedGO:00458938.5IL10, IL4, TNF, IL6, IL1B
48negative regulation of apoptotic processGO:00430668.5IL6, IL4, IL2, IL10, IL1RN
49response to drugGO:00424937.8IL10, IL1RN, IL4, IFNG, TNF, IL6
50positive regulation of transcription from RNA polymerase II promoterGO:00459446.6TNF, VDR, IFNG, IL1B, IL1A, IL10

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:00300209.7COL11A2, COL9A2, COL9A3
2interleukin-1 receptor bindingGO:00051499.3IL1A, IL1B, IL1RN
3growth factor activityGO:00080838.5IL6, IL10, IL2, IL4
4cytokine activityGO:00051256.6IL1A, IL1B, IL6, IL10, IL2, IL4

Sources for Intervertebral Disc Disease

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet