IDD
MCID: INT146
MIFTS: 47

Intervertebral Disc Disease (IDD) malady

Summaries for Intervertebral Disc Disease

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards: Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to osteoarthritis and osteoporosis. An important gene associated with Intervertebral Disc Disease is COL9A2 (collagen, type IX, alpha 2), and among its related pathways are PAK Pathway and Prion diseases. The compounds prednisolone and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and respiratory system.

Wikipedia:63 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:46 603932

Aliases & Classifications for Intervertebral Disc Disease

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42NIH Rare Diseases, 22GTR, 46OMIM, 44Novoseek, 60UMLS, 25ICD10
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Classifications:



Aliases & Descriptions:

intervertebral disc disease 42 22 46 44
intervertebral disc degeneration 42 60
intervertebral disc disorder 60
degenerative disc disease 42
idd 42


External Ids:

ICD1025 M51.3

Related Diseases for Intervertebral Disc Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to intervertebral disc disease

Clinical Features for Intervertebral Disc Disease

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46OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Intervertebral Disc Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intervertebral Disc Disease

Drug clinical trials:

Search ClinicalTrials for Intervertebral Disc Disease

Search NIH Clinical Center for Intervertebral Disc Disease

Search CenterWatch for Intervertebral Disc Disease

Genetic Tests for Intervertebral Disc Disease

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22GTR
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Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder22

Anatomical Context for Intervertebral Disc Disease

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Animal Models for Intervertebral Disc Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intervertebral Disc Disease:

36 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.8IL1RN, VDR
2MP:00053889.7IL6, IL4R
3MP:00036319.6MMP3, VDR, IL4R
4MP:00107719.4IL6, IL4R, VDR
5MP:00053908.9IL4, MMP3, IL6, COL11A2, IL1B
6MP:00053768.1IFNG, VDR, IL1RN, IL4R, IL4, IL2
7MP:00053857.6IL2, IL1A, IFNG, VDR, IL10, IL1RN
8MP:00020067.5TNF, IL10, IL6, IL2, IL1B, IFNG
9MP:00053827.3COL11A2, IL4, IFNG, IL10, VDR, TNF
10MP:00053797.2IFNG, IL2, TNF, VDR, IL4R, IL4
11MP:00053707.0TNF, IL10, IL4R, IL4, IL6, IL2
12MP:00053816.7VDR, IFNG, TNF, IL10, IL4R, IL4
13MP:00053976.1IL1RN, IFNG, IL4, TNF, VDR, IL2
14MP:00053846.0TNF, IL2, IL10, IL1RN, IFNG, IL6
15MP:00053786.0IL10, IL1RN, IL4, IL4R, IL6, IL2
16MP:00107685.9IL1RN, IL6, IFNG, TNF, VDR, IL10
17MP:00053875.6IL4R, MMP3, TNF, VDR, IL10, IL4

Publications for Intervertebral Disc Disease

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Genetic Variations for Intervertebral Disc Disease

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Intervertebral Disc Disease:

62
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Intervertebral Disc Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for genes affiliated with Intervertebral Disc Disease

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database
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Pathways related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2IL4R
210.2IL1A
39.9IL1B, IL1A
4
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9.9IL1A, IL4R
5
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9.9IL1A, IL4R
6
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9.7IL2, IL4R
7
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9.6IL4R, IL6
89.5IL4R, IL4, IL1B
9
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9.5IL4R, COL9A3, COL9A2, COL11A2
10
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9.4COL11A2, COL9A2, COL9A3, MMP3
11
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.0IL1A, VDR, IFNG
12
Development Thrombopoetin signaling via JAK-STAT pathway
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8.9IFNG, IL4, IL1RN
138.9IL1B, TNF, IFNG
14
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8.8IL6, IL1A, TNF, IL1B
158.8IL1A, TNF, VDR, IL10
168.8IL1B, IL6, MMP3, TNF
178.6IFNG, TNF, IL1A, IL1B
18
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8.5IL1B, IFNG, IL2, IL4
198.5IL2, IL4, IL4R, IFNG
20
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8.5IL2, IL6, IL1B, IL1A, IL1RN
21
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8.5IFNG, IL4, IL2, IL1A
228.5IL1A, IFNG, IL6, IL1B
238.4IL2, IL4R, IL6, COL11A2, IL4
248.3IL4, IFNG, IL2, IL10
25
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8.3IFNG, IL4, TNF, IL2
268.3IL1B, IL6, IL1A, IL10, TNF
278.3IL6, IL1B, IL1A, IL10, TNF
288.3IFNG, TNF, IL1B, IL6
29
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8.2IL6, IL2, TNF, IL4R, IL4
308.2IL6, IL2, IFNG, IL4
31
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8.2IL2, IL10, TNF, IFNG
328.1IL6, IL4R, IL1B, TNF, IL4, IL1A
338.1IFNG, TNF, IL2, IL6
34
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8.0IL4R, IL2, IL4, TNF, IFNG
35
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8.0IL1A, TNF, IFNG, IL6, IL1B
367.9IL1A, IL4, IL2, IL1B, TNF, IL6
377.9IL1B, IL6, IL1A, IL1RN, IL10, TNF
387.7IL1B, IL10, IFNG, TNF, IL6
39
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7.7IL1A, IL1B, IL6, IL2, IFNG, IL1RN
40
Immune response Bacterial infections in normal airways
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7.6IL6, IL1A, IL1RN, IL1B, TNF, IFNG
417.5TNF, IFNG, COL11A2, IL1B, IL6, IL10
42
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7.4IFNG, TNF, IL4R, IL4, IL1A, IL1B
437.4IL2, IL6, IL10, IL4, IL4R, IFNG
44
Development PDGF signaling via STATs and NF-kB
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7.3IL2, IFNG, TNF, IL10, IL1B, IL6
45
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7.3IL2, IL6, IL1B, IFNG, TNF, IL10
46
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7.3IL6, IL1B, IL2, TNF, IFNG, IL10
47
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7.1IL1A, IL4R, IL4, IL1B, IL10, IL2
48
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7.1TNF, IFNG, IL2, IL6, IL1B, IL1A
49
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6.7IL10, TNF, IFNG, IL1A, IL1B, IL6
506.6IL1B, IL6, IL2, IL1A, IL4, IL10

Compounds for genes affiliated with Intervertebral Disc Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.5MMP3
2pge24410.4IL2
3tenidap44 2811.2IL1A
4pentoxifylline44 1111.2IL1RN, IL4
5dexamethasone44 49 28 1112.6IL6, IL4R, VDR
62,5-oligoadenylate449.6TNF, IL2
7pdtc449.6IL6, IL1B, IL1A
8cyclosporin a44 28 5911.4IFNG, VDR, IL4R
9ivig449.4IFNG, IL1A, IL1RN
10gm-csf44 2810.0IL10, TNF, IFNG
11sulfasalazine44 28 49 1111.9IL1B, TNF, MMP3, IL1A, IL1RN
12toxin-1448.7TNF, IL10, IL1RN, IL1B, IL2
13leflunomide49 44 1110.7MMP3, TNF, IL1RN, IL1B, IL6
14anakinra44 119.6TNF, IL1RN, IL1B, IL6
15mip 1alpha448.5IL1B, IL4, IL6, IL10, TNF
16groalpha448.5IL6, IL1B, IL1A, IL10, TNF
17bucillamine448.5IFNG, IL6, IL2, IL1B
18lipoteichoic acid448.4TNF, IL10, IL6, IL1B, IL1RN
19alpha-galactosylceramide448.3IL4, IL2, IFNG, IL10
20vesnarinone448.3IFNG, TNF, IL1B, IL6
21gold sodium thiomalate448.2IL1A, IL1RN, TNF, IFNG, IL2, IL1B
22taurine chloramine448.2IL1B, TNF, IFNG, IL6, IL2
23interferon gamma448.1IFNG, TNF, IL10, IL2, IL4
24imiquimod44 28 59 1111.0IL6, IL10, IL1A, TNF, IFNG
25tarc447.9IL4R, TNF, IFNG, IL4, IL10, IL1A
26triptolide447.8MMP3, IL6, IL1B, TNF, IFNG, IL2
27ccl344 288.8IL6, IFNG, IL10, IL1A, IL1B, TNF
28adalimumab44 49 119.7IFNG, IL6, IL1RN, IL10, MMP3, TNF
2915-deoxy-delta-12,14-prostaglandin j2447.6IL10, IL6, IL1B, IL4, IFNG, TNF
30poly(i-c)447.5IL1B, IFNG, TNF, IL4, IL6
31okt3447.5TNF, IFNG, IL6, IL10, IL4, IL2
32etanercept44 49 119.5IL1RN, IL1B, IL6, MMP3, IL10, TNF
33ionomycin447.5IL4R, IFNG, IL1A, IL10, TNF, IL4
34herbimycin a44 598.4IL1A, IL1B, IL2, TNF, IL6, IL4
35thalidomide44 49 59 1110.4IFNG, TNF, IL10, IL1A, IL1B, IL2
36il-12447.3IFNG, TNF, IL10, IL4, IL2, IL1B
37rantes447.2IFNG, TNF, IL4R, IL2, IL6, IL1B
38polymyxin b447.1IFNG, TNF, IL10, IL4, IL1A, IL1B
39infliximab44 49 119.1MMP3, IL6, IL1B, IL4, IL1RN, IL10
40genistein44 28 59 2 11 2412.1IL2, IL1B, VDR, TNF, IFNG, MMP3
41polyinosinic-polycytidylic acid447.0IL2, IL6, IL1B, IL1A, IL4, IL10
42simvastatin44 49 59 28 11 2412.0IL10, IL6, MMP3, IL1A, IL4, IFNG
43actinomycin d446.8IL6, IL1B, IL1A, TNF, IL4, IL4R
44neopterin446.6IL4, IL2, IL6, IL1B, IL1A, IL1RN
45calcitriol44 59 11 249.6IL10, IFNG, TNF, VDR, IL4, IL1A
46sb 20358044 597.4MMP3, IL6, IL1B, IL1A, IL4, IL1RN
47histamine44 28 248.4IL2, MMP3, IL6, IL1B, IL4, IL4R
48thymidine44 247.3VDR, IL4R, IL4, IL1A, TNF, IFNG
49vegf446.2IL2, IL1B, IL1A, MMP3, IFNG, TNF
50il 10446.0IL2, IL6, IL1B, IL1A, IL4, IL4R

GO Terms for genes affiliated with Intervertebral Disc Disease

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16Gene Ontology
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Cellular components related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IXGO:0055949.7COL9A2, COL9A3
2external side of plasma membraneGO:0098978.1IL6, IL4, TNF, IFNG
3extracellular regionGO:0055766.3MMP3, IL1A, IL2, COL11A2, COL9A2, COL9A3
4extracellular spaceGO:0056155.6IL2, IL6, IL1B, IL1A, IL4, IL4R

Biological processes related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.3IL1A, IL1B
2sequestering of triglycerideGO:03073010.0TNF, IL1B
3positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
4chronic inflammatory response to antigenic stimulusGO:00243910.0TNF, IL1RN
5positive regulation of fever generationGO:03162210.0IL1B, TNF
6regulation of isotype switchingGO:0451919.9IL10, IL4
7type 2 immune responseGO:0420929.9IL10, IL4
8collagen catabolic processGO:0305749.8COL9A2, MMP3, COL9A3, COL11A2
9extracellular matrix disassemblyGO:0226179.8MMP3, COL9A2, COL11A2, COL9A3
10positive regulation of interleukin-2 biosynthetic processGO:0450869.8IL1B, IL1A
11positive regulation of T-helper 2 cell differentiationGO:0456309.8IL4R, IL6
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, IL1A, TNF
13positive regulation of mitosisGO:0458409.8IL1A, TNF, IL1B
14receptor biosynthetic processGO:0328009.8IL10, TNF
15regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.8TNF, IL1B
16negative regulation of cytokine secretion involved in immune responseGO:0027409.7IL10, TNF
17negative regulation of lipid catabolic processGO:0509959.7IL1B, TNF
18positive regulation of interleukin-6 biosynthetic processGO:0454109.6IL1B, IFNG
19positive regulation of interferon-gamma productionGO:0327299.6IL1B, TNF, IL2
20positive regulation of immunoglobulin secretionGO:0510249.6IL2, IL6
21negative regulation of nitric oxide biosynthetic processGO:0450199.5IL10, IL4
22epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.5IL6, TNF
23positive regulation of cytokine secretionGO:0507159.5IL1A, IL10, TNF
24positive regulation of vitamin D biosynthetic processGO:0605579.5TNF, IFNG
25negative regulation of lipid storageGO:0108889.5IL6, TNF
26positive regulation of interleukin-6 productionGO:0327559.4TNF, IL6, IL1B
27neutrophil apoptotic processGO:0017819.4IFNG, IL6
28positive regulation of calcidiol 1-monooxygenase activityGO:0605599.3TNF, IL1B, IFNG
29extracellular matrix organizationGO:0301989.3COL9A3, TNF, MMP3, COL11A2, COL9A2
30positive regulation of membrane protein ectodomain proteolysisGO:0510449.3IFNG, TNF, IL1B
31positive regulation of isotype switching to IgG isotypesGO:0483049.2IL2, IL4, IFNG
32positive regulation of MHC class II biosynthetic processGO:0453489.2IFNG, IL4, IL10
33negative regulation of growth of symbiont in hostGO:0441309.0TNF, IFNG, IL10
34regulation of insulin secretionGO:0507969.0IFNG, TNF, IL1B
35positive regulation of chemokine biosynthetic processGO:0450808.9IFNG, IL1B, TNF, IL4
36response to glucocorticoid stimulusGO:0513848.9IL6, IL1RN, IL10, TNF
37humoral immune responseGO:0069598.9TNF, IL6, IFNG
38immune responseGO:0069558.9IL4, IL1A, IL4R, IL1RN, IL1B, IL2
39positive regulation of T cell proliferationGO:0421028.8IL6, IL4, IL1B, IFNG
40defense response to protozoanGO:0428328.8IL4, IL6, IFNG, IL4R
41positive regulation of NF-kappaB transcription factor activityGO:0510928.8TNF, IL1B, IL6
42negative regulation of cell proliferationGO:0082858.8TNF, IL6, IL1B, VDR, IL1A
43cytokine-mediated signaling pathwayGO:0192218.7IL6, IL1A, IL1B, IFNG
44positive regulation of nitric oxide biosynthetic processGO:0454298.7IL6, IL1B, IFNG, TNF
45inflammatory responseGO:0069548.7IL10, TNF, IL1A, IL1B, IL6
46positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.6TNF, IL4, IL10, IL6, IL1B
47positive regulation of transcription, DNA-dependentGO:0458938.4TNF, IL1B, IL6, IL4, IL10
48negative regulation of apoptotic processGO:0430668.4IL4, IL6, IL10, IL2, IL1RN
49response to drugGO:0424937.7IL6, TNF, IL10, IL1RN, IL4, IFNG
50positive regulation of transcription from RNA polymerase II promoterGO:0459446.6IL1B, IL6, TNF, VDR, IL10, IL4

Molecular functions related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.6COL9A2, COL9A3, COL11A2
2interleukin-1 receptor bindingGO:0051499.3IL1RN, IL1B, IL1A
3growth factor activityGO:0080838.5IL2, IL6, IL4, IL10
4cytokine activityGO:0051256.6IL2, IFNG, TNF, IL10, IL4, IL1A

Products for genes affiliated with Intervertebral Disc Disease

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Sources for Intervertebral Disc Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet