IDD
MCID: INT146
MIFTS: 50

Intervertebral Disc Disease (IDD) malady

Summaries for Intervertebral Disc Disease

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards: Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to lumbar disc disease and osteoarthritis. An important gene associated with Intervertebral Disc Disease is COL9A2 (collagen, type IX, alpha 2), and among its related pathways are PAK Pathway and Prion diseases. The compounds prednisolone and pge2 have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related mouse phenotypes are reproductive system and respiratory system.

Wikipedia:64 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:47 603932

Aliases & Classifications for Intervertebral Disc Disease

Sources:
43NIH Rare Diseases, 22GTR, 47OMIM, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

intervertebral disc disease 43 22 47 45
intervertebral disc degeneration 43 61
intervertebral disc disorder 61
degenerative disc disease 43
idd 43


External Ids:

ICD1025 M51.3

Related Diseases for Intervertebral Disc Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to intervertebral disc disease

Clinical Features for Intervertebral Disc Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

603932

Drugs & Therapeutics for Intervertebral Disc Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intervertebral Disc Disease

Drug clinical trials:

Search ClinicalTrials for Intervertebral Disc Disease

Search NIH Clinical Center for Intervertebral Disc Disease

Search CenterWatch for Intervertebral Disc Disease

Genetic Tests for Intervertebral Disc Disease

Sources:
22GTR
See all sources

Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder22

Anatomical Context for Intervertebral Disc Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Intervertebral Disc Disease:

33
Spinal cord

Animal Models for Intervertebral Disc Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Intervertebral Disc Disease

Sources:
51PubMed
See all sources

Articles related to Intervertebral Disc Disease:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. (23702280)
2013
2
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. (22795604)
2013
3
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. (24338460)
2013
4
Reoperation rate after surgery for lumbar herniated intervertebral disc disease: nationwide cohort study. (23023591)
2013
5
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. (22912517)
2012
6
Increased expression of netrin-1 and its deleted in colorectal cancer receptor in human diseased lumbar intervertebral disc compared with autopsy control. (22588384)
2012
7
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. (22250714)
2012
8
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. (22105313)
2012
9
Magnetic resonance imaging diagnosis of intervertebral disc disease and myelomalacia in an American black bear (Ursus americanus). (22779249)
2012
10
Intervertebral disc disease in dogs. (20732594)
2010
11
Acupuncture treatment for feline multifocal intervertebral disc disease. (19186087)
2009
12
Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease. (19165512)
2009
13
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (18411503)
2008
14
Future perspectives of cell-based therapy for intervertebral disc disease. (19005704)
2008
15
Detection of spinal cord compression in dogs with cervical intervertebral disc disease by magnetic resonance imaging. (18603629)
2008
16
The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease. (18433481)
2008
17
Occupational and genetic risk factors associated with intervertebral disc disease. (17471097)
2007
18
'Rumours of my death may have been greatly exaggerated': a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy. (17635120)
2007
19
The role of collagen IX tryptophan polymorphisms in symptomatic intervertebral disc disease in Southern European patients. (15167667)
2004
20
Posterior surgical approach to the cervical neural foramen for intervertebral disc disease. (15028141)
2004
21
Intervertebral cages in the treatment of lumbar disc disease. (17675988)
2004
22
Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. (12698117)
2003
23
Gastric mucosal lesions in dogs with acute intervertebral disc disease: characterization and effects of omeprazole or misoprostol. (10668814)
2000
24
Laminectomy for 34 dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception. (10516947)
1999
25
Human group II phospholipase A2 in normal and diseased intervertebral discs. (8781537)
1996
26
Spinal cord swelling as a myelographic indicator of prognosis: a retrospective study in dogs with intervertebral disc disease and loss of deep pain perception. (8719081)
1996
27
Lumbar spinal surgery for sciatica due to intervertebral disc disease in the elderly. (8875503)
1996
28
Microsurgical management of the lumbar intervertebral disc-disease. (8570065)
1995
29
Biomechanical, radiologic, and histopathologic correlations in the pathogenesis of experimental intervertebral disc disease. (7809747)
1994
30
Intervertebral disc disease. (1641922)
1992
31
Lumbar intervertebral disc disease in the pediatric population. (1476937)
1992
32
Clinical aspects of lumbar intervertebral disc disease. (2212906)
1990
33
Intraoperative problems associated with intervertebral disc disease. (2520125)
1989
34
Selection of the appropriate surgical approach for intervertebral disc disease. (2520124)
1989
35
Problems and complications associated with the nonsurgical management of intervertebral disc disease. (2520123)
1989
36
Intervertebral disc disease. (2520118)
1989
37
Chemonucleolysis. The treatment of lumbar intervertebral disc disease by the intradiscal injection of chymopapain. (6371477)
1983
38
Late results of treatment of intervertebral disc disease with chymopapain. (6355406)
1983
39
Canine intervertebral disc disease: a review of etiologic and predisposing factors. (6755879)
1982
40
Canine cervical intervertebral disc disease. (551206)
1979
41
Proceedings: Intervertebral disc collagen in degenerative disc disease. (1221933)
1975
42
Regional use of steroids in the management of lumbar intervertebral disc disease. (1113969)
1975
43
Inadequacies and hazards of chymopapain injections as treatment for intervertebral disc disease. (123576)
1975
44
Comparison of intervertebral disc disease treatment by chymopapain injection and open surgery. (1123657)
1975
45
Intervertebral nerve-root in the investigation of chronic lumbar disc disease. (4267375)
1973
46
Conservative treatment of thoracolumbar intervertebral disc disease in the dog. (5884038)
1965
47
Inflammatory intervertebral disc disease as a complication of the operative treatment of lumbar herniations. (13655108)
1959
48
The lumbar intervertebral disc disease syndrome; clinical correlation of one hundred and seventy-five cases. (13268013)
1955
49
Herniation of thoracic intervertebral discs with spinal cord compression in kyphosis dorsalis juvenilis (Scheuermann's disease); case report. (13163735)
1954
50
Intervertebral disc disease; its recognition and treatment by the general practitioner. (18864529)
1948

Genetic Variations for Intervertebral Disc Disease

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Intervertebral Disc Disease:

63
id Symbol AA change Variation SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Intervertebral Disc Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for genes affiliated with Intervertebral Disc Disease

Sources:
52QIAGEN, 30KEGG, 54Reactome, 53R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database
See all sources

Pathways related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL4R
210.2IL1A
39.9IL1B, IL1A
4
Hide members
9.9IL1A, IL4R
5
Hide members
9.9IL1A, IL4R
6
Hide members
9.7IL2, IL4R
7
Hide members
9.6IL4R, IL6
89.5IL4R, IL4, IL1B
9
Hide members
9.5IL4R, COL9A3, COL9A2, COL11A2
10
Hide members
9.4COL11A2, COL9A2, COL9A3, MMP3
11
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0IL1A, VDR, IFNG
12
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
8.9IFNG, IL4, IL1RN
138.9IL1B, TNF, IFNG
14
Hide members
8.8IL6, IL1A, TNF, IL1B
158.8IL1A, TNF, VDR, IL10
168.8IL1B, IL6, MMP3, TNF
178.6IFNG, TNF, IL1A, IL1B
18
Hide members
8.5IL1B, IFNG, IL2, IL4
198.5IL2, IL4, IL4R, IFNG
20
Hide members
8.5IL2, IL6, IL1B, IL1A, IL1RN
21
Hide members
8.5IFNG, IL4, IL2, IL1A
228.5IL1A, IFNG, IL6, IL1B
238.4IL2, IL4R, IL6, COL11A2, IL4
248.3IL4, IFNG, IL2, IL10
25
Hide members
8.3IFNG, IL4, TNF, IL2
268.3IL1B, IL6, IL1A, IL10, TNF
278.3IL6, IL1B, IL1A, IL10, TNF
288.3IFNG, TNF, IL1B, IL6
29
Hide members
8.2IL6, IL2, TNF, IL4R, IL4
308.2IL6, IL2, IFNG, IL4
31
Hide members
8.2IL2, IL10, TNF, IFNG
328.1IL6, IL4R, IL1B, TNF, IL4, IL1A
338.1IFNG, TNF, IL2, IL6
34
Hide members
8.0IL4R, IL2, IL4, TNF, IFNG
35
Hide members
8.0IL1A, TNF, IFNG, IL6, IL1B
367.9IL1A, IL4, IL2, IL1B, TNF, IL6
377.9IL1B, IL6, IL1A, IL1RN, IL10, TNF
387.7IL1B, IL10, IFNG, TNF, IL6
39
Hide members
7.7IL1A, IL1B, IL6, IL2, IFNG, IL1RN
40
Immune response Bacterial infections in normal airways
Hide members
7.6IL6, IL1A, IL1RN, IL1B, TNF, IFNG
417.5TNF, IFNG, COL11A2, IL1B, IL6, IL10
42
Hide members
7.4IFNG, TNF, IL4R, IL4, IL1A, IL1B
437.4IL2, IL6, IL10, IL4, IL4R, IFNG
44
Development PDGF signaling via STATs and NF-kB
Hide members
7.3IL2, IFNG, TNF, IL10, IL1B, IL6
45
Hide members
7.3IL2, IL6, IL1B, IFNG, TNF, IL10
46
Hide members
7.3IL6, IL1B, IL2, TNF, IFNG, IL10
47
Hide members
7.1IL1A, IL4R, IL4, IL1B, IL10, IL2
48
Hide members
7.1TNF, IFNG, IL2, IL6, IL1B, IL1A
49
Hide members
6.7IL10, TNF, IFNG, IL1A, IL1B, IL6
506.6IL1B, IL6, IL2, IL1A, IL4, IL10

Compounds for genes affiliated with Intervertebral Disc Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 24HMDB
See all sources

Compounds related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1prednisolone45 29 1112.5MMP3
2pge24510.4IL2
3tenidap45 2911.2IL1A
4pentoxifylline45 1111.2IL1RN, IL4
5dexamethasone45 50 29 1112.6IL6, IL4R, VDR
62,5-oligoadenylate459.6TNF, IL2
7pdtc459.6IL6, IL1B, IL1A
8cyclosporin a45 29 6011.4IFNG, VDR, IL4R
9ivig459.4IFNG, IL1A, IL1RN
10gm-csf45 2910.0IL10, TNF, IFNG
11sulfasalazine45 29 50 1111.9IL1B, TNF, MMP3, IL1A, IL1RN
12toxin-1458.7TNF, IL10, IL1RN, IL1B, IL2
13leflunomide50 45 1110.7MMP3, TNF, IL1RN, IL1B, IL6
14anakinra45 119.6TNF, IL1RN, IL1B, IL6
15mip 1alpha458.5IL1B, IL4, IL6, IL10, TNF
16groalpha458.5IL6, IL1B, IL1A, IL10, TNF
17bucillamine458.5IFNG, IL6, IL2, IL1B
18lipoteichoic acid458.4TNF, IL10, IL6, IL1B, IL1RN
19alpha-galactosylceramide458.3IL4, IL2, IFNG, IL10
20vesnarinone458.3IFNG, TNF, IL1B, IL6
21gold sodium thiomalate458.2IL1A, IL1RN, TNF, IFNG, IL2, IL1B
22taurine chloramine458.2IL1B, TNF, IFNG, IL6, IL2
23interferon gamma458.1IFNG, TNF, IL10, IL2, IL4
24imiquimod45 29 60 1111.0IL6, IL10, IL1A, TNF, IFNG
25tarc457.9IL4R, TNF, IFNG, IL4, IL10, IL1A
26triptolide457.8MMP3, IL6, IL1B, TNF, IFNG, IL2
27ccl345 298.8IL6, IFNG, IL10, IL1A, IL1B, TNF
28adalimumab45 50 119.7IFNG, IL6, IL1RN, IL10, MMP3, TNF
2915-deoxy-delta-12,14-prostaglandin j2457.6IL10, IL6, IL1B, IL4, IFNG, TNF
30poly(i-c)457.5IL1B, IFNG, TNF, IL4, IL6
31okt3457.5TNF, IFNG, IL6, IL10, IL4, IL2
32etanercept45 50 119.5IL1RN, IL1B, IL6, MMP3, IL10, TNF
33ionomycin457.5IL4R, IFNG, IL1A, IL10, TNF, IL4
34herbimycin a45 608.4IL1A, IL1B, IL2, TNF, IL6, IL4
35thalidomide45 50 60 1110.4IFNG, TNF, IL10, IL1A, IL1B, IL2
36il-12457.3IFNG, TNF, IL10, IL4, IL2, IL1B
37rantes457.2IFNG, TNF, IL4R, IL2, IL6, IL1B
38polymyxin b457.1IFNG, TNF, IL10, IL4, IL1A, IL1B
39infliximab45 50 119.1MMP3, IL6, IL1B, IL4, IL1RN, IL10
40genistein45 29 60 2 11 2412.1IL2, IL1B, VDR, TNF, IFNG, MMP3
41polyinosinic-polycytidylic acid457.0IL2, IL6, IL1B, IL1A, IL4, IL10
42simvastatin45 50 60 29 11 2412.0IL10, IL6, MMP3, IL1A, IL4, IFNG
43actinomycin d456.8IL6, IL1B, IL1A, TNF, IL4, IL4R
44neopterin456.6IL4, IL2, IL6, IL1B, IL1A, IL1RN
45calcitriol45 60 11 249.6IL10, IFNG, TNF, VDR, IL4, IL1A
46sb 20358045 607.4MMP3, IL6, IL1B, IL1A, IL4, IL1RN
47histamine45 29 248.4IL2, MMP3, IL6, IL1B, IL4, IL4R
48thymidine45 247.3VDR, IL4R, IL4, IL1A, TNF, IFNG
49vegf456.2IL2, IL1B, IL1A, MMP3, IFNG, TNF
50il 10456.0IL2, IL6, IL1B, IL1A, IL4, IL4R

GO Terms for genes affiliated with Intervertebral Disc Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IXGO:0055949.7COL9A2, COL9A3
2external side of plasma membraneGO:0098978.1IL6, IL4, TNF, IFNG
3extracellular regionGO:0055766.3MMP3, IL1A, IL2, COL11A2, COL9A2, COL9A3
4extracellular spaceGO:0056155.6IL2, IL6, IL1B, IL1A, IL4, IL4R

Biological processes related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.3IL1A, IL1B
2sequestering of triglycerideGO:03073010.0TNF, IL1B
3positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
4chronic inflammatory response to antigenic stimulusGO:00243910.0TNF, IL1RN
5positive regulation of fever generationGO:03162210.0IL1B, TNF
6regulation of isotype switchingGO:0451919.9IL10, IL4
7type 2 immune responseGO:0420929.9IL10, IL4
8collagen catabolic processGO:0305749.8COL9A2, MMP3, COL9A3, COL11A2
9extracellular matrix disassemblyGO:0226179.8MMP3, COL9A2, COL11A2, COL9A3
10positive regulation of interleukin-2 biosynthetic processGO:0450869.8IL1B, IL1A
11positive regulation of T-helper 2 cell differentiationGO:0456309.8IL4R, IL6
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, IL1A, TNF
13positive regulation of mitosisGO:0458409.8IL1A, TNF, IL1B
14receptor biosynthetic processGO:0328009.8IL10, TNF
15regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.8TNF, IL1B
16negative regulation of cytokine secretion involved in immune responseGO:0027409.7IL10, TNF
17negative regulation of lipid catabolic processGO:0509959.7IL1B, TNF
18positive regulation of interleukin-6 biosynthetic processGO:0454109.6IL1B, IFNG
19positive regulation of interferon-gamma productionGO:0327299.6IL1B, TNF, IL2
20positive regulation of immunoglobulin secretionGO:0510249.6IL2, IL6
21negative regulation of nitric oxide biosynthetic processGO:0450199.5IL10, IL4
22epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.5IL6, TNF
23positive regulation of cytokine secretionGO:0507159.5IL1A, IL10, TNF
24positive regulation of vitamin D biosynthetic processGO:0605579.5TNF, IFNG
25negative regulation of lipid storageGO:0108889.5IL6, TNF
26positive regulation of interleukin-6 productionGO:0327559.4TNF, IL6, IL1B
27neutrophil apoptotic processGO:0017819.4IFNG, IL6
28positive regulation of calcidiol 1-monooxygenase activityGO:0605599.3TNF, IL1B, IFNG
29extracellular matrix organizationGO:0301989.3COL9A3, TNF, MMP3, COL11A2, COL9A2
30positive regulation of membrane protein ectodomain proteolysisGO:0510449.3IFNG, TNF, IL1B
31positive regulation of isotype switching to IgG isotypesGO:0483049.2IL2, IL4, IFNG
32positive regulation of MHC class II biosynthetic processGO:0453489.2IFNG, IL4, IL10
33negative regulation of growth of symbiont in hostGO:0441309.0TNF, IFNG, IL10
34regulation of insulin secretionGO:0507969.0IFNG, TNF, IL1B
35positive regulation of chemokine biosynthetic processGO:0450808.9IFNG, IL1B, TNF, IL4
36response to glucocorticoid stimulusGO:0513848.9IL6, IL1RN, IL10, TNF
37humoral immune responseGO:0069598.9TNF, IL6, IFNG
38immune responseGO:0069558.9IL4, IL1A, IL4R, IL1RN, IL1B, IL2
39positive regulation of T cell proliferationGO:0421028.8IL6, IL4, IL1B, IFNG
40defense response to protozoanGO:0428328.8IL4, IL6, IFNG, IL4R
41positive regulation of NF-kappaB transcription factor activityGO:0510928.8TNF, IL1B, IL6
42negative regulation of cell proliferationGO:0082858.8TNF, IL6, IL1B, VDR, IL1A
43cytokine-mediated signaling pathwayGO:0192218.7IL6, IL1A, IL1B, IFNG
44positive regulation of nitric oxide biosynthetic processGO:0454298.7IL6, IL1B, IFNG, TNF
45inflammatory responseGO:0069548.7IL10, TNF, IL1A, IL1B, IL6
46positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.6TNF, IL4, IL10, IL6, IL1B
47positive regulation of transcription, DNA-dependentGO:0458938.4TNF, IL1B, IL6, IL4, IL10
48negative regulation of apoptotic processGO:0430668.4IL4, IL6, IL10, IL2, IL1RN
49response to drugGO:0424937.7IL6, TNF, IL10, IL1RN, IL4, IFNG
50positive regulation of transcription from RNA polymerase II promoterGO:0459446.6IL1B, IL6, TNF, VDR, IL10, IL4

Molecular functions related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.6COL9A2, COL9A3, COL11A2
2interleukin-1 receptor bindingGO:0051499.3IL1RN, IL1B, IL1A
3growth factor activityGO:0080838.5IL2, IL6, IL4, IL10
4cytokine activityGO:0051256.6IL2, IFNG, TNF, IL10, IL4, IL1A

Products for genes affiliated with Intervertebral Disc Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intervertebral Disc Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet