MCID: INT146
MIFTS: 55

Intervertebral Disc Disease malady

Genetic diseases, Rare diseases categories

Summaries for Intervertebral Disc Disease

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NIH Rare Diseases:41 Intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards based summary: Intervertebral Disc Disease, also known as lumbar disc disease, is related to degenerative disc disease and osteoporosis. An important gene associated with Intervertebral Disc Disease is COL9A2 (collagen, type IX, alpha 2), and among its related pathways are Protein digestion and absorption and Collagen biosynthesis and modifying enzymes. The compounds toxin-1 and sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related mouse phenotypes are limbs/digits/tail and craniofacial.

OMIM:45 Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common... (603932) more...

Aliases & Classifications for Intervertebral Disc Disease

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Sources:
45OMIM, 10diseasecard, 41NIH Rare Diseases, 43Novoseek, 22GTR, 60UMLS, 25ICD10
See all sources

Intervertebral Disc Disease, Aliases & Descriptions:

Name: Intervertebral Disc Disease 45 41 43
Lumbar Disc Disease 45 43 60
Intervertebral Disc Disease, Susceptibility to 10 22
Intervertebral Disc Degeneration 41 60
Degeneration of Lumbar Intervertebral Disc 60
 
Intervertebral Disc Disorder 60
Degenerative Disc Disease 41
Lumbar Disc Degeneration 45
Lumbar Disc Herniation 45
Idd 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


External Ids:

OMIM45 603932
ICD1025 M51.3, M51.8

Related Diseases for Intervertebral Disc Disease

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Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1degenerative disc disease31.3COL9A3
2osteoporosis30.6IL1RN, MMP3, VDR, IL6
3pancreatitis30.6IL1B, IL10, IL6
4arthritis30.4IL1A, TNF, IL1B, MMP3, IL6
5atherosclerosis30.0MMP3, IL10, IL6, IL1RN, TNF, IL1A
6osteoarthritis28.9COL9A3, CILP, MMP3, ASPN, IL1RN, IL4R
7rheumatoid arthritis28.7IL1A, TNF, MMP3, IL1B, IL6, IL10
8cauda equina syndrome10.9
9back pain10.8
10radiculopathy10.8
11spinal stenosis10.7
12cervicitis10.6
13periapical granuloma10.6IL4
14dengue shock syndrome10.6IL1RN
15leprosy10.5IL2
16gastric cancer risk after h. pylori infection10.5IL1RN
17hyper-igd syndrome10.5IL1RN
18multiple epiphyseal dysplasia10.5COL9A2, COL9A3
19alkaptonuria10.5
20obesity10.5
21chronic pain10.5
22schnitzler syndrome10.5IL1RN
23osteochondritis dissecans10.5COL9A3, COL9A2
24conjunctivochalasis10.5MMP3
25spondylolisthesis10.5
26pulpitis10.5IL1A
27periodontitis10.5IL1A, IL1B
28multiple epiphyseal dysplasia, dominant10.5COL9A2, COL9A3
29capillary leak syndrome10.5IL2
30intraocular lymphoma10.5IL10
31hemangioma10.4
32spondylolysis10.4
33arachnoiditis10.4
34cinca syndrome10.4IL1B, IL1RN
35pseudoachondroplasia10.4COL9A2, COL9A3
36fibrochondrogenesis10.4COL11A1
37silicosis10.4IL1RN, IL1A
38euthyroid sick syndrome10.4IL6, IL1B
39pleurisy10.4IL1B
40meningitis10.4IL1B, IL6
41blau syndrome10.4TNF, IL1B
42selective iga deficiency disease10.4IL10, IL4
43diastrophic dysplasia10.4COL9A2, COL9A3
44gingival overgrowth10.4IL1B, IL1A, MMP3
45bacterial vaginosis10.4IL1A, IL1B
46poems syndrome10.4IL1B, IL6
47cutaneous leishmaniasis10.3IL10, IFNG
48agammaglobulinemia10.3IL2, IL4
49spinal cord injury10.3
50blindness10.3

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to intervertebral disc disease

Symptoms for Intervertebral Disc Disease

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Clinical features from OMIM:

603932

Drugs & Therapeutics for Intervertebral Disc Disease

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Drug clinical trials:

Search ClinicalTrials for Intervertebral Disc Disease

Search NIH Clinical Center for Intervertebral Disc Disease

Genetic Tests for Intervertebral Disc Disease

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Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder22

Anatomical Context for Intervertebral Disc Disease

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MalaCards organs/tissues related to Intervertebral Disc Disease:

31
Spinal cord

Animal Models for Intervertebral Disc Disease or affiliated genes

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Publications for Intervertebral Disc Disease

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Articles related to Intervertebral Disc Disease:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. (25694233)
2015
2
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications. (25523328)
2014
3
Lack of relationship between occupational workload and microscopic alterations in lumbar intervertebral disc disease. (25136392)
2014
4
Neurologic outcome after thoracolumbar partial lateral corpectomy for intervertebral disc disease in 72 dogs. (24484371)
2014
5
Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. (22805224)
2013
6
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. (23702280)
2013
7
The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. (23565773)
2013
8
Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. (24381451)
2013
9
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. (22795604)
2013
10
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. (24338460)
2013
11
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. (23240963)
2013
12
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. (22912517)
2012
13
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. (22250714)
2012
14
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. (22105313)
2012
15
Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. (22286190)
2012
16
Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs. (20195068)
2010
17
Acupuncture treatment for feline multifocal intervertebral disc disease. (19186087)
2009
18
A critical evaluation of discography in patients with lumbar intervertebral disc disease. (18069067)
2008
19
Continuous lumbar hemilaminectomy for intervertebral disc disease in an Amur tiger (Panthera tigris altaica). (18817014)
2008
20
Future perspectives of cell-based therapy for intervertebral disc disease. (19005704)
2008
21
Re: Virtanen IM, Karppinen J, Taimela S, et al. Occupational and genetic risk factors associated with intervertebral disc disease. Spine 2007;32:1129-34. (18246021)
2007
22
Surgical decompression in dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception: A retrospective study of 46 cases. (16108215)
2005
23
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. (15733644)
2005
24
The anterior surgical approach to the cervical spine for intervertebral disc disease. (15113469)
2004
25
The role of collagen IX tryptophan polymorphisms in symptomatic intervertebral disc disease in Southern European patients. (15167667)
2004
26
Posterior surgical approach to the cervical neural foramen for intervertebral disc disease. (15028141)
2004
27
An allele of COL9A2 associated with intervertebral disc disease. (10411504)
1999
28
Cervical monosegmental interbody fusion using titanium implants in degenerative, intervertebral disc disease. (10228933)
1999
29
Spinal cord swelling as a myelographic indicator of prognosis: a retrospective study in dogs with intervertebral disc disease and loss of deep pain perception. (8719081)
1996
30
Microsurgical management of the lumbar intervertebral disc-disease. (8570065)
1995
31
Biomechanical, radiologic, and histopathologic correlations in the pathogenesis of experimental intervertebral disc disease. (7809747)
1994
32
Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease. (8488675)
1993
33
Intervertebral disc disease. (1641922)
1992
34
Lumbar intervertebral disc disease in the pediatric population. (1476937)
1992
35
Surgical treatments for intervertebral disc disease. (1641923)
1992
36
Surgical management of lumbar intervertebral-disc disease. (2674153)
1989
37
Intraoperative problems associated with intervertebral disc disease. (2520125)
1989
38
Neuroanatomic and pathophysiologic aspects of intervertebral disc disease in the dog. (2520119)
1989
39
Canine intervertebral disc disease: a review of etiologic and predisposing factors. (6755879)
1982
40
Clinical aspects of lumbar intervertebral disc disease. (7217799)
1981
41
Canine cervical intervertebral disc disease. (551206)
1979
42
New knowledge of intervertebral disc disease. (365890)
1978
43
Chymopapain treatment of intervertebral disc disease. (123575)
1975
44
The surgical approach to canine intervertebral disc disease. (4795128)
1973
45
Recent advances in the diagnosis of intervertebral disc disease. (4723646)
1973
46
Lumbar intervertebral disc disease in the elderly. (4239509)
1969
47
Lumbar intervertebral disc disease in Africans. (6018777)
1967
48
Conservative treatment of thoracolumbar intervertebral disc disease in the dog. (5884038)
1965
49
Review of the present position in spinal intervertebral disc disease. (13878294)
1962
50
The lumbar intervertebral disc disease syndrome; clinical correlation of one hundred and seventy-five cases. (13268013)
1955

Variations for Intervertebral Disc Disease

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UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

62
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Intervertebral Disc Disease

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Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for genes affiliated with Intervertebral Disc Disease

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Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6COL11A2, COL9A2, COL11A1, COL9A3
2
Show member pathways
9.3MMP3, COL11A2, COL9A2, COL11A1, COL9A3
3
Show member pathways
9.1MMP3, ASPN, COL11A2, COL9A2, COL11A1, COL9A3
48.9IL4, IL4R, IL6, IL1B
5
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.5IFNG, IL4, IL2, IL1B
68.5IL1A, IL1B, IL6, IFNG
78.5IFNG, IL4, IL2, IL4R
8
Show member pathways
8.5IL2, IL6, COL11A2, COL9A2, COL11A1, COL9A3
9
Show member pathways
8.4IL2, IL1RN, IL6, IL1B, IL1A
10
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.4TNF, IL1RN, IL6, IL1B, IL1A
118.3TNF, IL10, IL6, IL1B, IL1A
128.3TNF, IL10, IL6, IL1B, IL1A
138.3IFNG, IL4, IL2, IL10
14
Show member pathways
thioredoxin pathway36
8.3TNF, IFNG, IL6, IL1B
15
Show member pathways
8.3TNF, IL2, IL6, IL1B, IL1A
16
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.2TNF, IFNG, IL4, IL2
17
Show member pathways
8.2IL10, IL2, IFNG, TNF
18
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.2TNF, IL4, IL2, IL4R, IL6
198.1IFNG, IL4, IL2, IL6
20
Show member pathways
8.1IFNG, IL4, IL4R, IL6, IL1B
218.1TNF, IL4, IL4R, IL6, IL1B, IL1A
228.0TNF, IFNG, IL2, IL6
238.0TNF, IL1RN, IL10, IL6, IL1B, IL1A
248.0THBS2, IL4, IL2, IL4R, IL6, COL11A2
25
Show member pathways
Immune response MIF in innate immunity response58
8.0TNF, IFNG, IL6, IL1B, IL1A
267.8TNF, IFNG, IL10, IL6, IL1B
277.6TNF, MMP3, IFNG, IL6, IL1B, IL1A
28
Show member pathways
7.6IFNG, IL2, IL1RN, IL6, IL1B, IL1A
29
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
7.6TNF, IFNG, IL4, IL6, IL1B, IL1A
307.6THBS2, TNF, IFNG, IL10, IL6, IL1B
317.5VDR, TNF, IFNG, IL6, IL1B, IL1A
32
Show member pathways
7.4TNF, IFNG, IL4, IL2, IL4R, IL1B
33
Show member pathways
Type III interferon signaling36
7.4IFNG, IL4, IL2, IL4R, IL10, IL6
347.3TNF, IFNG, IL10, IL6, IL1B, COL11A2
35
Show member pathways
IL27-mediated signaling events36
7.3TNF, IFNG, IL2, IL10, IL6, IL1B
36
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.3TNF, IFNG, IL2, IL10, IL6, IL1B
37
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
7.3TNF, IFNG, IL2, IL10, IL6, IL1B
38
Show member pathways
7.1IL1B, IL6, IL10, IL4R, IL2, IL4
39
Show member pathways
7.1TNF, IL1A, IL1B, IL6, IL10, IL4R
407.1VDR, TNF, IFNG, IL10, IL6, IL1B
41
Show member pathways
7.1TNF, IFNG, IL4, IL2, IL6, IL1B
427.1TNF, IFNG, IL4, IL2, IL6, IL1B
436.6IL1A, IL1B, IL6, IL10, IL2, IL4
44
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
6.6TNF, IFNG, IL4, IL2, IL10, IL6
456.6IL4, IFNG, TNF, IL2, IL10, IL1A
46
Show member pathways
6.3IL1A, IL1B, IL6, IL10, IL4R, IL2
47
Show member pathways
6.3TNF, IFNG, IL4, IL2, IL4R, IL10
48
Show member pathways
6.3TNF, IFNG, IL4, IL2, IL4R, IL10
49
Show member pathways
6.3TNF, IFNG, IL4, IL2, IL4R, IL10
50
Show member pathways
6.3IL10, IL4R, IL2, IL4, TNF, IL6

Compounds for genes affiliated with Intervertebral Disc Disease

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Compounds related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idCompoundScoreTop Affiliating Genes
1toxin-1438.7IL1RN, IL1B, IL10, TNF, IL2
2sulfasalazine28 43 49 1211.6TNF, IL1A, IL1RN, MMP3, IL1B
3mip 1alpha438.6IL1B, IL6, IL10, IL4, TNF
4leflunomide43 49 1210.5IL6, IL1RN, MMP3, IL1B, TNF
5groalpha438.4IL1A, IL1B, IL6, IL10, TNF
6lipoteichoic acid438.3IL1RN, IL1B, TNF, IL10, IL6
7interferon gamma438.2IL2, IL4, IFNG, IL10, TNF
8gold sodium thiomalate438.1IL1A, IL1RN, IL2, IFNG, TNF, IL1B
9taurine chloramine438.1IL1B, IL6, TNF, IL2, IFNG
10tarc438.0IL4R, IL1A, IL10, IL4, IFNG, TNF
11tgf beta1438.0THBS2, MMP3, TNF, IL6, IL1B, IL10
12bucillamine438.0IFNG, IL1B, IL6, IL2
13imiquimod43 59 28 1211.0IL1A, IL6, IL10, IFNG, TNF
14ccl343 288.8IFNG, IL1A, IL1B, IL6, IL10, TNF
15adalimumab43 49 129.8MMP3, IFNG, TNF, IL10, IL6, IL1RN
16triptolide437.8IL2, IFNG, IL6, MMP3, IL1B, TNF
17pdtc437.8IL1A, TNF, IFNG, IL4, IL1B, IL6
1815-deoxy-delta-12,14-prostaglandin j2437.6IL4, IL1B, IL6, IFNG, TNF, IL10
192,5-oligoadenylate437.5IL10, IL6, IFNG, TNF, IL2
20etanercept43 49 129.5IFNG, IL1B, IL6, IL10, MMP3, TNF
21okt3437.5IFNG, IL6, TNF, IL2, IL10, IL4
22ionomycin437.4IL4R, IL2, IL10, IL1A, IFNG, TNF
23endotoxin437.4IL1A, IL1RN, IL1B, IL6, IL10, IFNG
24thalidomide43 49 59 1210.3IL6, IL2, IL10, IFNG, TNF, IL1A
25herbimycin a43 598.3IFNG, IL4, IL2, IL6, IL1B, IL1A
26il-12437.3IFNG, IL1B, IL6, IL10, IL2, IL4
27rantes437.2IL1B, IL1A, IL10, MMP3, IFNG, IL4
28ivig437.2IL1B, IL6, IFNG, TNF, IL1A, IL4
29polymyxin b437.2IL10, IL1RN, IL1A, IL1B, IL6, IL4
30infliximab43 49 129.2TNF, MMP3, IFNG, IL4, IL1RN, IL10
31prednisolone43 28 129.2IFNG, TNF, MMP3, IL2, IL1RN, IL6
32simvastatin43 49 59 28 24 1212.1IFNG, IL1RN, IL10, IL4, MMP3, TNF
33polyinosinic-polycytidylic acid437.0IFNG, TNF, IL10, IL2, IL4, IL1A
34gm-csf43 288.0IL1A, IL1B, IL6, IL10, IL2, IL4
35genistein43 28 59 2 24 1211.9MMP3, TNF, IFNG, IL2, IL6, IL1B
36indomethacin43 28 59 129.8IL1RN, IL6, TNF, MMP3, IFNG, IL1A
37actinomycin d436.7IL1A, IL4, IL4R, IL6, VDR, TNF
38hydrocortisone43 2 59 129.7TNF, IFNG, IL4, IL2, IL1RN, IL10
39pentoxifylline43 127.7IL10, IL1RN, IL6, IL1B, IL1A, IL2
40neopterin436.7IL4, IL2, IL1RN, IL10, IL6, IL1B
41calcitriol43 59 24 129.6IL4, TNF, IFNG, VDR, IL2, IL10
42sb 20358043 597.5VDR, TNF, MMP3, IFNG, IL4, IL1RN
43histamine43 28 248.4TNF, MMP3, IFNG, IL4, IL2, IL1RN
44thymidine43 247.1IL4, IL2, IL4R, IL10, IL6, IL1B
45vegf436.1IL4, IL2, IFNG, IL1A, MMP3, TNF
46il 10436.0IFNG, TNF, VDR, IL6, IL4R, IL1RN
47cyclosporin a43 28 597.9IL10, IL6, IL1A, IL4R, IL1RN, VDR
48pge2435.9IL1RN, IL1A, IL1B, IL6, IL10, IFNG
49cycloheximide435.7IL1A, VDR, MMP3, TNF, IFNG, IL1B
50dexamethasone43 49 28 128.7VDR, IL1A, IL1B, IL6, TNF, MMP3

GO Terms for genes affiliated with Intervertebral Disc Disease

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Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen type XIGO:000559210.0COL11A2, COL11A1
2collagen type IXGO:000559410.0COL9A2, COL9A3
3endoplasmic reticulum lumenGO:00057889.3COL11A2, COL9A2, COL11A1, COL9A3
4external side of plasma membraneGO:00098978.1IL6, IL4, IFNG, TNF
5extracellular regionGO:00055766.1COL9A3, IL1A, IL6, IL2, IFNG, MMP3
6extracellular spaceGO:00056155.5IL6, IL1B, IL10, IL4R, IL1RN, IL2

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:000178110.2IL6
2sequestering of triglycerideGO:003073010.0TNF, IL1B
3ectopic germ cell programmed cell deathGO:003523410.0IL1B, IL1A
4fever generationGO:000166010.0IL1RN, IL1B, IL1A
5regulation of isotype switchingGO:004519110.0IL4, IL10
6chronic inflammatory response to antigenic stimulusGO:000243910.0IL1RN, TNF
7positive regulation of fever generationGO:003162210.0IL1B, TNF
8type 2 immune responseGO:004209210.0IL10, IL4
9positive regulation of heterotypic cell-cell adhesionGO:003411610.0IL1B, TNF
10positive regulation of interleukin-2 biosynthetic processGO:00450869.9IL1A, IL1B
11receptor biosynthetic processGO:00328009.8TNF, IL10
12positive regulation of T-helper 2 cell differentiationGO:00456309.8IL6, IL4R
13positive regulation of mitosisGO:00458409.8TNF, IL1B, IL1A
14negative regulation of cytokine secretion involved in immune responseGO:00027409.8IL10, TNF
15negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.8TNF, IL1B, IL1A
16collagen catabolic processGO:00305749.7MMP3, COL11A2, COL9A2, COL11A1, COL9A3
17extracellular matrix disassemblyGO:00226179.7MMP3, COL11A2, COL9A2, COL11A1, COL9A3
18regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.6IL1B, TNF
19positive regulation of cytokine secretionGO:00507159.6IL1A, IL10, TNF
20positive regulation of interleukin-6 biosynthetic processGO:00454109.5IFNG, IL1B
21positive regulation of interferon-gamma productionGO:00327299.5IL1B, IL2, TNF
22epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.5TNF, IL6
23positive regulation of immunoglobulin secretionGO:00510249.5IL2, IL6
24positive regulation of vitamin D biosynthetic processGO:00605579.5IFNG, TNF
25extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.5IL1A, IL1B, IL2, IL4
26positive regulation of interleukin-6 productionGO:00327559.4TNF, IL6, IL1B
27negative regulation of lipid storageGO:00108889.4TNF, IL6
28negative regulation of nitric oxide biosynthetic processGO:00450199.3IL10, IL4
29positive regulation of calcidiol 1-monooxygenase activityGO:00605599.3TNF, IFNG, IL1B
30positive regulation of membrane protein ectodomain proteolysisGO:00510449.3TNF, IFNG, IL1B
31positive regulation of MHC class II biosynthetic processGO:00453489.2IFNG, IL4, IL10
32positive regulation of isotype switching to IgG isotypesGO:00483049.2IL2, IL4, IFNG
33extracellular matrix organizationGO:00301989.2TNF, MMP3, COL11A2, COL9A2, COL11A1, COL9A3
34negative regulation of growth of symbiont in hostGO:00441309.1TNF, IFNG, IL10
35positive regulation of chemokine biosynthetic processGO:00450809.0IL1B, IL4, IFNG, TNF
36response to glucocorticoidGO:00513848.9IL6, IL10, IL1RN, TNF
37regulation of insulin secretionGO:00507968.9TNF, IFNG, IL1B
38defense response to protozoanGO:00428328.8IFNG, IL4, IL4R, IL6
39positive regulation of T cell proliferationGO:00421028.8IL1B, IL6, IL4, IFNG
40immune responseGO:00069558.8IL4, IL2, IL1RN, IL4R, IL1B, IL1A
41humoral immune responseGO:00069598.8TNF, IFNG, IL6
42negative regulation of cell proliferationGO:00082858.7VDR, TNF, IL6, IL1B, IL1A
43cytokine-mediated signaling pathwayGO:00192218.7IFNG, IL6, IL1B, IL1A
44inflammatory responseGO:00069548.7TNF, IL10, IL6, IL1B, IL1A
45positive regulation of nitric oxide biosynthetic processGO:00454298.7IL1B, IL6, IFNG, TNF
46positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.7TNF, IL4, IL10, IL6, IL1B
47positive regulation of transcription, DNA-templatedGO:00458938.5TNF, IL4, IL10, IL6, IL1B
48negative regulation of apoptotic processGO:00430668.5IL4, IL2, IL1RN, IL10, IL6
49response to drugGO:00424937.8TNF, IFNG, IL4, IL1RN, IL10, IL6
50positive regulation of transcription from RNA polymerase II promoterGO:00459446.6VDR, TNF, IFNG, IL4, IL2, IL10

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:00300209.7COL11A2, COL9A2, COL9A3
2interleukin-1 receptor bindingGO:00051499.3IL1A, IL1B, IL1RN
3growth factor activityGO:00080838.5IL6, IL10, IL2, IL4
4cytokine activityGO:00051256.6IL1A, IL1B, IL6, IL10, IL2, IL4

Products for genes affiliated with Intervertebral Disc Disease

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Sources for Intervertebral Disc Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet