IDD
MCID: INT146
MIFTS: 60

Intervertebral Disc Disease (IDD) malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Intervertebral Disc Disease

Aliases & Descriptions for Intervertebral Disc Disease:

Name: Intervertebral Disc Disease 54 50 25 66 52
Intervertebral Disc Degeneration 50 25 42 69
Lumbar Disc Disease 54 66 52 69
Intervertebral Disc Disorder 25 29 69
Idd 50 25 66
Intervertebral Disk Disease 66 29
Lumbar Disc Degeneration 54 66
Lumbar Disc Herniation 54 66
Intervertebral Disc Disease, Susceptibility to 13
Degeneration of Lumbar Intervertebral Disc 69
Intervertebral Disk Degeneration 25
Intervertebral Disc Displacement 42
Intervertebral Disk Displacement 69
Disorder of Intervertebral Disc 25
Degenerative Disc Disease 50
Discogenic Disorder 25
Discogenic Disease 25
Ldd 66
Ldh 66

Classifications:



External Ids:

OMIM 54 603932
ICD10 33 M51.8

Summaries for Intervertebral Disc Disease

NIH Rare Diseases : 50 intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards based summary : Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to cowden syndrome 1 and lactate dehydrogenase deficiency, and has symptoms including sciatica An important gene associated with Intervertebral Disc Disease is COL9A2 (Collagen Type IX Alpha 2 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and Allograft rejection. The drugs Midazolam and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone and spinal cord, and related phenotypes are cardiovascular system and immune system

Genetics Home Reference : 25 Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine.

OMIM : 54 Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common... (603932) more...

UniProtKB/Swiss-Prot : 66 Intervertebral disc disease: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.

Wikipedia : 71 An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the... more...

Related Diseases for Intervertebral Disc Disease

Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
id Related Disease Score Top Affiliating Genes
1 cowden syndrome 1 11.5
2 lactate dehydrogenase deficiency 11.5
3 lactate dehydrogenase b deficiency 11.5
4 degenerative disc disease 11.5
5 spondyloepiphyseal dysplasia with congenital joint dislocations 11.1
6 glycogen storage disease due to lactate dehydrogenase deficiency 10.8
7 fanconi-bickel syndrome 10.8
8 cauda equina syndrome 10.4
9 mild hemophilia a 10.3 COL9A2 COL9A3
10 myopia, x-linked 10.3 COL9A2 COL9A3
11 oculomotor nerve paralysis 10.2 IL1B IL6
12 common peroneal nerve lesion 10.2 IL1B IL6
13 swine influenza 10.2 IL1A IL6
14 cervicitis 10.2
15 childhood electroclinical syndrome 10.2 IL1B IL6
16 neonatal hypoxic and ischemic brain injury 10.2 IL6 MMP9
17 physical disorder 10.2 CILP COL9A2 COL9A3
18 anal paget's disease 10.1 IL1A IL1B IL6
19 steroid dehydrogenase deficiency dental anomalies 10.1 IL1A IL1B IL6
20 mikulicz disease 10.1 IL1A IL1B IL6
21 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL1A IL1B IL6
22 inappropriate adh syndrome 10.1 IL1A IL1B IL6
23 warm antibody hemolytic anemia 10.1 COL11A1 COL9A2
24 immunoglobulin g deficiency 10.1 IL1A IL1B IL6
25 glucosephosphate dehydrogenase deficiency 10.1 IL1B IL6
26 baritosis 10.1 IL1A IL1B IL6
27 classic type lipoma 10.1 IL1A IL1B IL6
28 maternally-inherited mitochondrial dystonia 10.1 COL11A1 COL9A2 COL9A3
29 parasitic protozoa infectious disease 10.1 IL1A IL1B IL6
30 charcot-marie-tooth disease type 5 10.1 COL11A1 COL9A2 COL9A3
31 bare lymphocyte syndrome, type i 10.1 IL1A IL1B IL6
32 bipolar i disorder 10.1 IL1B IL6
33 intracranial hemorrhage in brain cerebrovascular malformations 10.1 IL1A IL1B IL6
34 band keratopathy 10.1 IL1A IL1B IL6
35 chordoid meningioma 10.1 IL1B IL6 MMP9
36 uterine adnexa cancer 10.1 IL1B IL6 MMP9
37 dentin dysplasia 10.1 ASPN COL9A3 VDR
38 toxic optic neuropathy 10.1 IL1A IL1B MMP9
39 histiocytoid hemangioma 10.1 IL1B IL6 MMP9
40 optic nerve hypoplasia 10.1 IL1B IL6 MMP9
41 pulmonary eosinophilia 10.0 IL1B IL6 MMP9
42 acute chest syndrome 10.0 IL1B IL6 MMP9
43 bone resorption disease 10.0 CILP COL9A2 COL9A3 IL1B
44 labyrinthitis 10.0 IL1B IL6 VDR
45 thymic neuroendocrine carcinoma 10.0 IL2 IL6
46 acute allergic sanguinous otitis media 10.0 IL2 IL6
47 osteonecrosis 10.0 ASPN CILP IL1B IL6
48 afibrinogenemia 10.0 IL6 VDR
49 leukoplakia of vagina 10.0 IL6 MMP9 VDR
50 laryngotracheoesophageal cleft type 2 10.0 IL1B IL2 IL6

Comorbidity relations with Intervertebral Disc Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Heart Disease
Hypertension, Essential Ischemic Heart Disease
Osteoporosis

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to Intervertebral Disc Disease

Symptoms & Phenotypes for Intervertebral Disc Disease

Clinical features from OMIM:

603932

UMLS symptoms related to Intervertebral Disc Disease:


sciatica

MGI Mouse Phenotypes related to Intervertebral Disc Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 IL1A IL1B IL2 IL6 MMP9 THBS2
2 immune system MP:0005387 9.86 COL11A1 IL1A IL1B IL2 IL6 MMP9
3 limbs/digits/tail MP:0005371 9.63 ASPN COL11A1 COL9A2 MMP9 THBS2 VDR
4 neoplasm MP:0002006 9.43 IL1A IL1B IL2 IL6 MMP9 THBS2
5 skeleton MP:0005390 9.17 COL11A1 COL9A2 IL1B IL6 MMP9 THBS2

Drugs & Therapeutics for Intervertebral Disc Disease

Drugs for Intervertebral Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 189)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
2
Bupivacaine Approved, Investigational Phase 4,Phase 3,Early Phase 1 2180-92-9, 38396-39-3 2474
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1 437-38-7 3345
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Morphine Approved, Investigational Phase 4 57-27-2 5288826
6
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 137-58-6 3676
8
Remifentanil Approved Phase 4 132875-61-7 60815
9
Magnesium Sulfate Approved, Vet_approved Phase 4 7487-88-9 24083
10
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
11
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
12
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
13
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 50-24-8 5755
15
Acetaminophen Approved Phase 4 103-90-2 1983
16
Ibuprofen Approved Phase 4 15687-27-1 3672
17
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
18
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
19
Norepinephrine Approved Phase 4 51-41-2 439260
20
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
21 Analgesics Phase 4,Phase 3,Phase 2
22 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2
23 Anticonvulsants Phase 4,Phase 3,Phase 2
24 calcium channel blockers Phase 4,Phase 3,Phase 2
25 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
26 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Psychotropic Drugs Phase 4,Phase 3,Phase 2
29 Tranquilizing Agents Phase 4,Phase 3,Phase 2
30 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
31 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Early Phase 1
32
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2
33 Adrenergic Agents Phase 4,Phase 2
34 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
35 Anti-Inflammatory Agents Phase 4,Phase 3
36 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
37 triamcinolone acetonide Phase 4
38 Triamcinolone diacetate Phase 4
39 Triamcinolone hexacetonide Phase 4
40 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
41 Antirheumatic Agents Phase 4,Phase 3
42 Cyclooxygenase Inhibitors Phase 4,Phase 3
43 Antidepressive Agents Phase 4,Phase 2
44 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
45 Analgesics, Opioid Phase 4,Phase 3
46 Narcotics Phase 4,Phase 3
47 Anesthetics, General Phase 4
48 Anesthetics, Intravenous Phase 4
49 Hypnotics and Sedatives Phase 4
50 Adjuvants, Anesthesia Phase 4

Interventional clinical trials:

(show top 50) (show all 377)
id Name Status NCT ID Phase
1 Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™ Unknown status NCT02425514 Phase 4
2 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
3 Analgetic and Anxiolytic Effect of Preoperative Pregabalin Completed NCT00353704 Phase 4
4 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
5 Barricaid EU Post Market Study for Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
6 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4
7 Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery Completed NCT01843296 Phase 4
8 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
9 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4
10 Study of the Efficacy of Preoperative Cefuroxime Prophylaxis to Prevent Surgical Site Infection in Herniated Disk Surgery Completed NCT00530400 Phase 4
11 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
12 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
13 CHARITE™ vs. ALIF 5-Year Follow-up Completed NCT00215332 Phase 4
14 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
15 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4
16 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4
17 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
18 Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis Completed NCT00000411 Phase 4
19 Intra-discal Steroid Injection for MODIC I Discopathy Completed NCT00804531 Phase 4
20 C7-T1 Epidural Steroid Injections Versus Targeted Injection for Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4
21 Post Market Non-Inferiority Study Comparing Triojection® to Discectomy for Lumbar Disc Herniation Recruiting NCT02525120 Phase 4
22 Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy Recruiting NCT02414698 Phase 4
23 Pentoxifylline and Lumbar Radiculopathy Recruiting NCT03060434 Phase 4
24 Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody Fusion Recruiting NCT01549366 Phase 4
25 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
26 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
27 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
28 Percutaneous Transforaminal Endoscopic Discectomy vs Microendoscopic Discectomy for Treatment of Lumbar Disc Herniation Active, not recruiting NCT01997086 Phase 4
29 A Prospective, Randomized, Multicenter Study to Demonstrate the Superiority of the Barricaid to Discectomy for Primary Lumbar Disc Herniation Active, not recruiting NCT01283438 Phase 4
30 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Active, not recruiting NCT02429908 Phase 4
31 Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF) Active, not recruiting NCT01016314 Phase 4
32 Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) Active, not recruiting NCT02182843 Phase 4
33 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Active, not recruiting NCT02535000 Phase 4
34 Comparison of Complication Rates Between Lateral Approaches to the Lumbar Spine Enrolling by invitation NCT02068729 Phase 4
35 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
36 Feasibility Study of Balloon Kyphoplasty in Traumatic Vertebral Fractures Needing Surgical Fixation Terminated NCT00749229 Phase 4
37 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
38 CARES Lumbar Artificial Disc Registry Terminated NCT02139527 Phase 4
39 Surgical Treatment Comparison for Recurrent Lumbar Disc Herniation Withdrawn NCT00444405 Phase 4
40 ADALISKIAS: Adalimumab for Acute Disc Prolapse Unknown status NCT01510548 Phase 3
41 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
42 Physiotherapy Following Disc Surgery: Long Term Follow-up of a RCT Completed NCT01922063 Phase 3
43 Randomized Controlled Study to Assess the Efficacy of a Dietary Ingredient in Patients With Herniated Lumbar Disc Compression Completed NCT00405041 Phase 2, Phase 3
44 Nucleoplasty for Contained Herniated Lumbar Discs Completed NCT00124774 Phase 3
45 The Efficacy and Safety of the 1,414 nm Nd:YAG Laser System for Alleviating Back Pain in a Lumbar Disc Patient Completed NCT02598232 Phase 2, Phase 3
46 Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery Completed NCT02120703 Phase 3
47 SI-6603 Versus Placebo in Patients With Lumbar Disc Herniation Completed NCT00634946 Phase 2, Phase 3
48 The Value of Traction in the Treatment of Cervical Radiculopathy Completed NCT00979108 Phase 3
49 The Value of Traction in Treatment of Lumbar Radiculopathy Completed NCT00942227 Phase 3
50 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3

Search NIH Clinical Center for Intervertebral Disc Disease

Cochrane evidence based reviews: intervertebral disc degeneration

Genetic Tests for Intervertebral Disc Disease

Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder 29
2 Abnormality of the Intervertebral Disk 29

Anatomical Context for Intervertebral Disc Disease

MalaCards organs/tissues related to Intervertebral Disc Disease:

39
Bone, Spinal Cord

Publications for Intervertebral Disc Disease

Articles related to Intervertebral Disc Disease:

(show top 50) (show all 97)
id Title Authors Year
1
Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease. ( 28343922 )
2017
2
Asthma and early herniated intervertebral disc disease. ( 28498027 )
2017
3
Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety and Preliminary Results. ( 28471303 )
2017
4
Genetic Alterations in Intervertebral Disc Disease. ( 27917384 )
2016
5
Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease. ( 26956825 )
2016
6
The efficacy of interlaminar epidural steroid administration in multilevel intervertebral disc disease with chronic low back pain: a randomized, blinded, prospective Study. ( 27555486 )
2016
7
Complex Regional Pain Syndrome Caused by Lumbar Herniated Intervertebral Disc Disease. ( 27454281 )
2016
8
ICD-10: Intervertebral Disc Disease. ( 27514110 )
2016
9
Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats. ( 26868632 )
2016
10
DachsLife 2015: an investigation of lifestyle associations with the risk of intervertebral disc disease in Dachshunds. ( 27826450 )
2016
11
Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. ( 26743937 )
2016
12
Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population. ( 28002589 )
2016
13
Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. ( 25694233 )
2015
14
Thoracolumbar partial lateral corpectomy for the treatment of chronic intervertebral disc disease in 107 dogs. ( 26629329 )
2015
15
Advancing the cellular and molecular therapy for intervertebral disc disease. ( 24993611 )
2014
16
Neurologic outcome after thoracolumbar partial lateral corpectomy for intervertebral disc disease in 72 dogs. ( 24484371 )
2014
17
Lack of relationship between occupational workload and microscopic alterations in lumbar intervertebral disc disease. ( 25136392 )
2014
18
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications. ( 25523328 )
2014
19
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. ( 22795604 )
2013
20
The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. ( 23565773 )
2013
21
Intervertebral disc disease in dogs - part 1: a new histological grading scheme for classification of intervertebral disc degeneration in dogs. ( 22789628 )
2013
22
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. ( 23702280 )
2013
23
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. ( 23240963 )
2013
24
Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. ( 24381451 )
2013
25
Acute adverse events associated with ventral slot decompression in 546 dogs with cervical intervertebral disc disease. ( 23980621 )
2013
26
Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. ( 22805224 )
2013
27
Reoperation rate after surgery for lumbar herniated intervertebral disc disease: nationwide cohort study. ( 23023591 )
2013
28
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. ( 24338460 )
2013
29
Magnetic resonance imaging diagnosis of intervertebral disc disease and myelomalacia in an American black bear (Ursus americanus). ( 22779249 )
2012
30
Comparison of computed tomography and myelography to a reference standard of computed tomographic myelography for evaluation of dogs with intervertebral disc disease. ( 22091972 )
2012
31
Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. ( 22286190 )
2012
32
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. ( 22250714 )
2012
33
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. ( 22912517 )
2012
34
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. ( 22105313 )
2012
35
Agreement between T2 and haste sequences in the evaluation of thoracolumbar intervertebral disc disease in dogs. ( 22168798 )
2012
36
Intervertebral disc disease in dogs. ( 20732594 )
2010
37
Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs. ( 20195068 )
2010
38
Acupuncture treatment for feline multifocal intervertebral disc disease. ( 19186087 )
2009
39
A critical evaluation of discography in patients with lumbar intervertebral disc disease. ( 18069067 )
2008
40
Continuous lumbar hemilaminectomy for intervertebral disc disease in an Amur tiger (Panthera tigris altaica). ( 18817014 )
2008
41
Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease. ( 18520934 )
2008
42
Future perspectives of cell-based therapy for intervertebral disc disease. ( 19005704 )
2008
43
Detection of spinal cord compression in dogs with cervical intervertebral disc disease by magnetic resonance imaging. ( 18603629 )
2008
44
'Rumours of my death may have been greatly exaggerated': a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy. ( 17635120 )
2007
45
Occupational and genetic risk factors associated with intervertebral disc disease. ( 17471097 )
2007
46
Acute non-ambulatory tetraparesis attributable to cranial cervical intervertebral disc disease in a cat. ( 17560823 )
2007
47
Re: Virtanen IM, Karppinen J, Taimela S, et al. Occupational and genetic risk factors associated with intervertebral disc disease. Spine 2007;32:1129-34. ( 18246021 )
2007
48
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. ( 15733644 )
2005
49
Surgical decompression in dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception: A retrospective study of 46 cases. ( 16108215 )
2005
50
Posterior surgical approach to the cervical neural foramen for intervertebral disc disease. ( 15028141 )
2004

Variations for Intervertebral Disc Disease

UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

66
id Symbol AA change Variation ID SNP ID
1 COL9A2 p.Gln326Trp VAR_012658 rs137853213

Expression for Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for Intervertebral Disc Disease

Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 41)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 COL11A1 COL9A2 COL9A3 IL2 IL6
2
Show member pathways
12.72 IL1A IL1B IL2 IL6
3
Show member pathways
12.71 COL11A1 COL9A2 COL9A3 MMP9
4
Show member pathways
12.67 IL1A IL1B IL2 IL6
5
Show member pathways
12.58 IL1A IL1B IL2 IL6
6
Show member pathways
12.58 ASPN COL11A1 COL9A2 COL9A3 MMP9
7
Show member pathways
12.48 IL1A IL1B IL2 IL6
8 12.34 COL9A2 COL9A3 IL2 IL6 THBS2
9
Show member pathways
12.3 IL1A IL1B IL2 IL6
10
Show member pathways
12.15 IL1A IL1B IL6
11 12.06 IL1A IL1B IL6
12 12.03 IL1A IL1B IL6 VDR
13
Show member pathways
12.02 COL9A2 COL9A3 THBS2
14 11.98 IL1A IL1B MMP9
15
Show member pathways
11.92 IL1A IL1B IL2
16
Show member pathways
11.88 IL1A IL1B IL2 IL6
17 11.85 IL1B IL6 MMP9
18
Show member pathways
11.84 IL1B IL2 IL6
19 11.83 IL1A IL1B IL6
20 11.79 IL1A IL1B IL6
21 11.78 IL1A IL1B IL6
22 11.74 IL1A IL1B IL6
23 11.72 IL1A IL1B IL6
24 11.68 IL1A IL1B IL6 MMP9
25 11.66 IL1B IL2 IL6
26 11.65 IL1A IL1B IL6
27 11.63 IL1A IL1B IL2 IL6 MMP9
28 11.54 IL1B IL6 MMP9
29 11.49 ASPN COL9A2 COL9A3
30 11.41 IL1A IL1B IL6
31 11.4 IL1B IL6 THBS2
32 11.35 IL1A IL1B IL6
33 11.21 IL1A IL1B IL6 VDR
34 11.18 IL1A IL1B IL6
35 11.15 IL1A IL1B IL6
36 11.07 IL1B MMP9
37 11.04 IL1A IL1B IL2 IL6
38 10.83 IL1B IL6
39
Show member pathways
10.82 IL1A IL1B IL2 IL6 MMP9
40 10.73 IL1A IL1B IL2 IL6
41 10.42 IL1A IL1B

GO Terms for Intervertebral Disc Disease

Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 CILP COL11A1 IL1A IL1B IL2 IL6
2 endoplasmic reticulum lumen GO:0005788 9.67 COL11A1 COL9A2 COL9A3 IL6
3 extracellular matrix GO:0031012 9.65 ASPN CILP COL11A1 MMP9 THBS2
4 extracellular region GO:0005576 9.65 ASPN COL11A1 COL9A2 COL9A3 IL1A IL1B
5 collagen trimer GO:0005581 9.58 COL11A1 COL9A2 COL9A3
6 collagen type IX trimer GO:0005594 9.32 COL9A2 COL9A3
7 proteinaceous extracellular matrix GO:0005578 9.17 ASPN CILP COL11A1 COL9A2 COL9A3 MMP9

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.98 IL1A IL1B IL2 IL6 VDR
2 immune response GO:0006955 9.87 IL1A IL1B IL2 IL6
3 negative regulation of cell proliferation GO:0008285 9.81 IL1A IL1B IL6 VDR
4 positive regulation of gene expression GO:0010628 9.8 IL1A IL1B IL6 VDR
5 positive regulation of protein phosphorylation GO:0001934 9.71 IL1B IL2 MMP9
6 skeletal system development GO:0001501 9.7 COL9A2 MMP9 VDR
7 extracellular matrix organization GO:0030198 9.62 COL11A1 COL9A2 COL9A3 MMP9
8 endodermal cell differentiation GO:0035987 9.58 COL11A1 MMP9
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.56 IL1A IL1B
10 positive regulation of mitotic nuclear division GO:0045840 9.55 IL1A IL1B
11 positive regulation of T cell proliferation GO:0042102 9.54 IL1B IL2 IL6
12 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.48 IL1A IL1B
13 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL2 IL6
14 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.43 IL1A IL1B
15 positive regulation of interleukin-6 production GO:0032755 9.43 IL1A IL1B IL6
16 ectopic germ cell programmed cell death GO:0035234 9.4 IL1A IL1B
17 cytokine-mediated signaling pathway GO:0019221 9.26 ASPN IL1A IL1B IL6
18 fever generation GO:0001660 9.16 IL1A IL1B
19 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 8.8 IL1A IL1B IL2

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1A IL1B
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL9A2 COL9A3
3 cytokine activity GO:0005125 8.92 IL1A IL1B IL2 IL6

Sources for Intervertebral Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....