IDD
MCID: INT146
MIFTS: 58

Intervertebral Disc Disease (IDD) malady

Genetic diseases, Rare diseases categories
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Summaries for Intervertebral Disc Disease

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NIH Rare Diseases:42 Intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards based summary: Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to degenerative disc disease and osteoporosis. An important gene associated with Intervertebral Disc Disease is COL9A2 (collagen, type IX, alpha 2), and among its related pathways are Collagen biosynthesis and modifying enzymes and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds tenidap and sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related mouse phenotypes are no phenotypic analysis and craniofacial.

Wikipedia:65 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:46 603932

Aliases & Classifications for Intervertebral Disc Disease

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Sources:
42NIH Rare Diseases, 62UMLS, 22GTR, 46OMIM, 44Novoseek, 25ICD10
See all sources

Intervertebral Disc Disease, Aliases & Descriptions:

Name: Intervertebral Disc Disease 42 22 46 44
Intervertebral Disc Degeneration 42 62
Degenerative Disc Disease 42 62
 
Intervertebral Disc Disorder 62
Idd 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


External Ids:

ICD1025 M51.3

Related Diseases for Intervertebral Disc Disease

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Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1degenerative disc disease32.7COL9A3, COL9A2
2osteoporosis30.3IL1RN, IL6, MMP3, VDR
3pancreatitis30.3IL1B, IL6, IL10
4osteoarthritis29.0IL1B, IL1A, COL11A2, COL9A2, COL9A3, IL6
5back pain10.7
6cervicitis10.6
7dengue shock syndrome10.5IL1RN
8periapical granuloma10.5IL4
9spondylosis10.5
10gastric cancer risk after h. pylori infection10.5IL1RN
11hyper-igd syndrome10.5IL1RN
12schnitzler syndrome10.5IL1RN
13conjunctivochalasis10.5MMP3
14pulpitis10.5IL1A
15osteochondritis dissecans10.5COL9A3, COL9A2
16multiple epiphyseal dysplasia10.5COL9A3, COL9A2
17leprosy10.5IL2
18pleurisy10.5IL1B
19multiple epiphyseal dysplasia, dominant10.4COL9A3, COL9A2
20spondylolisthesis10.4
21periodontitis10.4IL1A, IL1B
22intraocular lymphoma10.4IL10
23pseudoachondroplasia10.4COL9A2, COL9A3
24capillary leak syndrome10.4IL2
25stickler syndrome10.4COL9A2, COL11A2
26diastrophic dysplasia10.4COL9A3, COL9A2
27chronic infantile neurological cutaneous articular syndrome10.4IL1RN, IL1B
28bacterial vaginosis10.4IL1A, IL1B
29silicosis10.4IL1A, IL1RN
30blau syndrome10.3IL1B, TNF
31spinal cord injury10.3
32blindness10.3
33lumbar disc disease10.3VDR, COL9A3, COL9A2
34allergic rhinitis10.3IL4, IL4R
35gingival overgrowth10.3IL1A, IL1B, MMP3
36selective iga deficiency disease10.3IL10, IL4
37gingivitis10.3IL1B, IL1A
38spondylolysis10.3
39spondyloepiphyseal dysplasia with congenital joint dislocations10.3
40hyperostosis10.3
41meningitis10.3IL6, IL1B
42euthyroid sick syndrome10.3IL1B, IL6
43aids dementia complex10.3TNF, IL1B
44poems syndrome10.2IL6, IL1B
45familial mediterranean fever10.2IL1B, TNF
46bruton-type agammaglobulinemia10.2IL2, IL4
47alcoholic hepatitis10.2IL1A, TNF
48aspergillosis10.2IFNG
49interstitial lung disease10.2IL1RN, IL1A
50systemic scleroderma10.2IL1A, MMP3, IL4

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to intervertebral disc disease

Symptoms for Intervertebral Disc Disease

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Clinical features from OMIM:

603932

Drugs & Therapeutics for Intervertebral Disc Disease

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Drug clinical trials:

Search ClinicalTrials for Intervertebral Disc Disease

Search NIH Clinical Center for Intervertebral Disc Disease

Genetic Tests for Intervertebral Disc Disease

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Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder22

Anatomical Context for Intervertebral Disc Disease

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MalaCards organs/tissues related to Intervertebral Disc Disease:

32
Spinal cord

Animal Models for Intervertebral Disc Disease or affiliated genes

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MGI Mouse Phenotypes related to Intervertebral Disc Disease:

36 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030127.8IL10, IL2, IL4, IFNG, TNF
2MP:00053827.5VDR, TNF, IFNG, IL4, IL10, COL11A2
3MP:00020067.2TNF, IFNG, IL2, IL10, IL6, IL1B
4MP:00053707.1TNF, IFNG, IL4, IL2, IL4R, IL10
5MP:00053887.0TNF, IFNG, IL4, IL2, IL4R, IL10
6MP:00107716.8VDR, TNF, IFNG, IL4, IL1RN, IL4R
7MP:00053816.7VDR, TNF, IFNG, IL4, IL2, IL4R
8MP:00053896.7VDR, TNF, IFNG, IL4, IL2, IL1RN
9MP:00053796.7VDR, TNF, IFNG, IL4, IL2, IL4R
10MP:00053856.5VDR, TNF, IFNG, IL2, IL1RN, IL10
11MP:00036316.5VDR, TNF, MMP3, IFNG, IL4, IL4R
12MP:00053906.4VDR, TNF, MMP3, IFNG, IL4, IL1RN
13MP:00053846.2VDR, TNF, IFNG, IL4, IL2, IL1RN
14MP:00053786.1VDR, TNF, IFNG, IL4, IL2, IL1RN
15MP:00107685.9VDR, TNF, IFNG, IL4, IL2, IL1RN
16MP:00053975.6IL1A, VDR, TNF, MMP3, IFNG, IL4
17MP:00053875.6IL4, IFNG, MMP3, TNF, VDR, IL2
18MP:00053765.5IL4, IFNG, MMP3, TNF, VDR, IL2

Publications for Intervertebral Disc Disease

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Articles related to Intervertebral Disc Disease:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Lack of relationship between occupational workload and microscopic alterations in lumbar intervertebral disc disease. (25136392)
2014
2
Neurologic outcome after thoracolumbar partial lateral corpectomy for intervertebral disc disease in 72 dogs. (24484371)
2014
3
Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. (22805224)
2013
4
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. (23702280)
2013
5
The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. (23565773)
2013
6
Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. (24381451)
2013
7
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. (22795604)
2013
8
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. (24338460)
2013
9
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. (23240963)
2013
10
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. (22912517)
2012
11
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. (22250714)
2012
12
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. (22105313)
2012
13
Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. (22286190)
2012
14
Intervertebral disc disease in dogs. (20732594)
2010
15
Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs. (20195068)
2010
16
Acupuncture treatment for feline multifocal intervertebral disc disease. (19186087)
2009
17
A critical evaluation of discography in patients with lumbar intervertebral disc disease. (18069067)
2008
18
Continuous lumbar hemilaminectomy for intervertebral disc disease in an Amur tiger (Panthera tigris altaica). (18817014)
2008
19
Future perspectives of cell-based therapy for intervertebral disc disease. (19005704)
2008
20
Re: Virtanen IM, Karppinen J, Taimela S, et al. Occupational and genetic risk factors associated with intervertebral disc disease. Spine 2007;32:1129-34. (18246021)
2007
21
Occupational and genetic risk factors associated with intervertebral disc disease. (17471097)
2007
22
Surgical decompression in dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception: A retrospective study of 46 cases. (16108215)
2005
23
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. (15733644)
2005
24
The anterior surgical approach to the cervical spine for intervertebral disc disease. (15113469)
2004
25
The role of collagen IX tryptophan polymorphisms in symptomatic intervertebral disc disease in Southern European patients. (15167667)
2004
26
Posterior surgical approach to the cervical neural foramen for intervertebral disc disease. (15028141)
2004
27
An allele of COL9A2 associated with intervertebral disc disease. (10411504)
1999
28
Cervical monosegmental interbody fusion using titanium implants in degenerative, intervertebral disc disease. (10228933)
1999
29
Spinal cord swelling as a myelographic indicator of prognosis: a retrospective study in dogs with intervertebral disc disease and loss of deep pain perception. (8719081)
1996
30
Microsurgical management of the lumbar intervertebral disc-disease. (8570065)
1995
31
Biomechanical, radiologic, and histopathologic correlations in the pathogenesis of experimental intervertebral disc disease. (7809747)
1994
32
Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease. (8488675)
1993
33
Intervertebral disc disease. (1641922)
1992
34
Lumbar intervertebral disc disease in the pediatric population. (1476937)
1992
35
Surgical treatments for intervertebral disc disease. (1641923)
1992
36
Surgical management of lumbar intervertebral-disc disease. (2674153)
1989
37
Intraoperative problems associated with intervertebral disc disease. (2520125)
1989
38
Neuroanatomic and pathophysiologic aspects of intervertebral disc disease in the dog. (2520119)
1989
39
Canine intervertebral disc disease: a review of etiologic and predisposing factors. (6755879)
1982
40
Clinical aspects of lumbar intervertebral disc disease. (7217799)
1981
41
Canine cervical intervertebral disc disease. (551206)
1979
42
New knowledge of intervertebral disc disease. (365890)
1978
43
Chymopapain treatment of intervertebral disc disease. (123575)
1975
44
The surgical approach to canine intervertebral disc disease. (4795128)
1973
45
Recent advances in the diagnosis of intervertebral disc disease. (4723646)
1973
46
Lumbar intervertebral disc disease in the elderly. (4239509)
1969
47
Lumbar intervertebral disc disease in Africans. (6018777)
1967
48
Conservative treatment of thoracolumbar intervertebral disc disease in the dog. (5884038)
1965
49
Review of the present position in spinal intervertebral disc disease. (13878294)
1962
50
Intervertebral disc disease; its recognition and treatment by the general practitioner. (18864529)
1948

Variations for Intervertebral Disc Disease

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UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

64
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Intervertebral Disc Disease

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Expression patterns in normal tissues for genes affiliated with Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for genes affiliated with Intervertebral Disc Disease

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Pathways related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4MMP3, COL9A3, COL11A2, COL9A2
28.9IL6, IL4, IL4R, IL1B
38.8IL1B, TNF, MMP3, IL6
48.6IL1B, IFNG, TNF, IL1A
5
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.5IFNG, IL4, IL1B, IL2
68.5IL1B, IL1A, IFNG, IL6
7
Show member pathways
8.5IL6, IL1B, IL1A, IFNG
88.5IFNG, IL4, IL4R, IL2
9
Show member pathways
8.4IL1B, IL2, IL1RN, IL6, IL1A
10
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.4TNF, IL1RN, IL6, IL1A, IL1B
118.4COL11A2, IL6, IL4R, IL2, IL4
128.3IL1A, IL1B, IL10, TNF, IL6
138.3IL1B, IL1A, IL6, IL10, TNF
148.3IFNG, IL2, IL4, IL10
15
Show member pathways
8.3IL1A, TNF, IL2, IL6, IL1B
16
Show member pathways
thioredoxin pathway37
8.3IL1B, TNF, IFNG, IL6
17
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.2IFNG, TNF, IL4, IL2
18
Show member pathways
8.2TNF, IL2, IFNG, IL10
19
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.2TNF, IL2, IL4, IL4R, IL6
208.1IL6, IL2, IL4, IFNG
21
Show member pathways
8.1IL4, IL4R, IL6, IFNG, IL1B
228.1TNF, IL4, IL4R, IL6, IL1B, IL1A
238.0TNF, IFNG, IL2, IL6
248.0IL1RN, IL6, IL1B, IL10, TNF, IL1A
25
Show member pathways
Immune response MIF in innate immunity response60
8.0IFNG, IL6, IL1B, TNF, IL1A
267.8IL1B, IL6, IFNG, TNF, IL10
277.8TNF, IL10, IL6, IL1B, IFNG
287.6IL6, IL1B, MMP3, TNF, IFNG, IL1A
29
Show member pathways
7.6IFNG, IL2, IL1RN, IL6, IL1A, IL1B
30
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
7.6TNF, IFNG, IL6, IL1B, IL1A, IL4
317.5VDR, IL1B, TNF, IFNG, IL6, IL1A
327.5TNF, IL10, IFNG, COL11A2, IL1B, IL6
33
Show member pathways
7.4IL4R, IL2, IFNG, TNF, IL1B, IL4
34
Show member pathways
Type III interferon signaling37
7.4IL6, IL10, IL4R, IL2, IL4, IFNG
35
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
7.3IFNG, TNF, IL2, IL10, IL1B, IL6
36
Show member pathways
IL27-mediated signaling events37
7.3IL1B, IL6, IL10, IL2, IFNG, TNF
37
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
7.3IL1B, IL2, IL10, IFNG, IL6, TNF
38
Show member pathways
7.1TNF, IL1A, IL6, IL10, IL4R, IL2
39
Show member pathways
7.1IL10, TNF, IL4, IL1A, IL1B, IL6
407.1IL1B, TNF, VDR, IFNG, IL10, IL6
41
Show member pathways
7.1TNF, IL4, IL2, IL1B, IL1A, IL6
427.1IFNG, IL1A, IL1B, IL6, IL2, TNF
43
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
6.6IL1A, IL1B, IL10, IL6, IL2, IL4
446.6TNF, IL1B, IL6, IL1A, IL10, IL2
456.6IL4, IFNG, IL2, IL10, IL6, IL1B
46
Show member pathways
6.4IL2, IL10, COL9A3, COL9A2, COL11A2, IL1A
47
Show member pathways
6.3IL2, IL10, TNF, IFNG, IL1B, IL4
48
Show member pathways
6.3IL10, IL1B, IL6, IL4R, IL2, IL4
49
Show member pathways
6.3IL1B, IL1A, IL4, IFNG, TNF, IL4R
50
Show member pathways
6.3IL4, IL2, IL4R, IL10, IL6, IFNG

Compounds for genes affiliated with Intervertebral Disc Disease

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Compounds related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 202)
idCompoundScoreTop Affiliating Genes
1tenidap44 289.8TNF, IL1A, IL1B, IL6
2sulfasalazine28 44 50 1111.7IL1RN, TNF, MMP3, IL1B, IL1A
3toxin-1448.7IL1B, IL1RN, IL2, TNF, IL10
4leflunomide44 50 1110.6IL1RN, TNF, IL6, MMP3, IL1B
5mip 1alpha448.6IL1B, TNF, IL4, IL10, IL6
6groalpha448.4IL1A, IL1B, IL6, TNF, IL10
7lipoteichoic acid448.3TNF, IL1RN, IL10, IL6, IL1B
8bucillamine448.2IFNG, IL2, IL1B, IL6
9interferon gamma448.2IFNG, IL4, IL2, TNF, IL10
10gold sodium thiomalate448.1IL1RN, TNF, IFNG, IL2, IL1B, IL1A
11taurine chloramine448.1TNF, IFNG, IL2, IL6, IL1B
12tarc448.0IFNG, TNF, IL4R, IL1A, IL10, IL4
13imiquimod44 61 28 1110.9IL6, IL10, TNF, IFNG, IL1A
14pdtc447.8IFNG, IL1A, IL6, IL4, TNF, IL1B
15ccl344 288.8IL10, IL1A, IL1B, TNF, IFNG, IL6
16adalimumab44 50 119.8IFNG, IL10, TNF, IL6, MMP3, IL1RN
17triptolide447.8IL1B, IL6, IL2, MMP3, TNF, IFNG
1815-deoxy-delta-12,14-prostaglandin j2447.7IL1B, IL6, IL10, IFNG, TNF, IL4
19etanercept44 50 119.5TNF, MMP3, IFNG, IL1RN, IL10, IL6
20okt3447.5IL2, IL6, IL10, IFNG, TNF, IL4
21ionomycin447.5IL2, IL4, IFNG, TNF, IL4R, IL10
22endotoxin447.4IFNG, IL1RN, IL10, TNF, IL1B, IL1A
23herbimycin a44 618.4IL4, IFNG, IL1B, TNF, IL1A, IL6
24thalidomide44 50 61 1110.3IL1B, IFNG, TNF, IL1A, IL6, IL10
25il-12447.3IL2, IL10, IL6, IL1B, IL4, IFNG
26rantes447.2IL1A, IL1B, MMP3, IFNG, IL4, IL2
272,5-oligoadenylate447.2IFNG, IL2, TNF, IL6, IL10
28polymyxin b447.2IL1A, IL1B, TNF, IFNG, IL4, IL1RN
29ivig447.2TNF, IFNG, IL4, IL1RN, IL10, IL6
30infliximab44 50 119.2TNF, MMP3, IFNG, IL1RN, IL1B, IL6
31prednisolone44 28 119.2IFNG, IL6, IL10, TNF, IL1RN, MMP3
32simvastatin44 50 61 28 24 1112.1IL1A, IL1RN, IL10, IL6, IFNG, MMP3
33gm-csf44 288.0TNF, IFNG, IL4, IL2, IL10, IL6
34polyinosinic-polycytidylic acid447.0TNF, IFNG, IL4, IL2, IL10, IL6
35genistein44 28 61 2 24 1111.9IL1B, IL1A, TNF, IL6, IL2, IFNG
36indomethacin44 28 61 119.8TNF, MMP3, IFNG, IL4, IL2, IL1RN
37actinomycin d446.7IFNG, VDR, IL6, IL1B, IL4R, IL2
38neopterin446.7IL6, IL1B, IL1A, IL10, IL1RN, TNF
39pentoxifylline44 117.7TNF, IFNG, IL4, IL2, IL1RN, IL10
40hydrocortisone44 2 61 119.6IL1B, IL1A, IL6, IL10, IL1RN, IL2
41calcitriol44 61 24 119.6VDR, TNF, IFNG, IL4, IL1A, IL1B
42sb 20358044 617.5IFNG, IL4, IL10, IL6, IL1B, IL1A
43histamine44 28 248.4TNF, MMP3, IFNG, IL4, IL2, IL1RN
44thymidine44 247.3IL1A, IL1B, IL6, IL10, IL4R, IL2
45vegf446.3IL4, IL2, IL1B, IL1A, IL1RN, IL10
46il 10446.0IL4, IL2, IL1RN, IL4R, IL10, IL6
47cyclosporin a44 28 617.9VDR, TNF, MMP3, IFNG, IL4, IL2
48pge2445.9VDR, TNF, MMP3, IFNG, IL4, IL2
49cycloheximide445.6VDR, TNF, MMP3, IFNG, IL4, IL2
50dexamethasone44 50 28 118.6IL6, IL1B, IL1A, IL10, IL4R, TNF

GO Terms for genes affiliated with Intervertebral Disc Disease

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Cellular components related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.7COL9A3, COL9A2, COL11A2
2collagen type IXGO:0055949.7COL9A3, COL9A2
3external side of plasma membraneGO:0098978.0TNF, IFNG, IL4, IL6
4extracellular regionGO:0055766.4IL2, IFNG, MMP3, TNF, IL6, IL1B
5extracellular spaceGO:0056155.7IL1A, TNF, MMP3, IFNG, IL4, IL2

Biological processes related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:00178110.2IL6
2ectopic germ cell programmed cell deathGO:03523410.0IL1B, IL1A
3sequestering of triglycerideGO:03073010.0TNF, IL1B
4fever generationGO:00166010.0IL1RN, IL1B, IL1A
5regulation of isotype switchingGO:04519110.0IL4, IL10
6chronic inflammatory response to antigenic stimulusGO:00243910.0IL1RN, TNF
7positive regulation of heterotypic cell-cell adhesionGO:03411610.0TNF, IL1B
8positive regulation of fever generationGO:03162210.0TNF, IL1B
9type 2 immune responseGO:0420929.9IL10, IL4
10positive regulation of interleukin-2 biosynthetic processGO:0450869.9IL1A, IL1B
11receptor biosynthetic processGO:0328009.8TNF, IL10
12collagen catabolic processGO:0305749.8MMP3, COL11A2, COL9A2, COL9A3
13extracellular matrix disassemblyGO:0226179.8MMP3, COL11A2, COL9A2, COL9A3
14positive regulation of T-helper 2 cell differentiationGO:0456309.8IL6, IL4R
15positive regulation of mitosisGO:0458409.8TNF, IL1B, IL1A
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8TNF, IL1B, IL1A
17negative regulation of cytokine secretion involved in immune responseGO:0027409.7TNF, IL10
18regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.6IL1B, TNF
19positive regulation of cytokine secretionGO:0507159.6IL1A, IL10, TNF
20positive regulation of interleukin-6 biosynthetic processGO:0454109.5IFNG, IL1B
21positive regulation of interferon-gamma productionGO:0327299.5IL1B, IL2, TNF
22positive regulation of immunoglobulin secretionGO:0510249.5IL6, IL2
23epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.5IL6, TNF
24positive regulation of vitamin D biosynthetic processGO:0605579.5IFNG, TNF
25extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5IL4, IL2, IL1B, IL1A
26positive regulation of interleukin-6 productionGO:0327559.4TNF, IL6, IL1B
27negative regulation of lipid storageGO:0108889.4TNF, IL6
28negative regulation of nitric oxide biosynthetic processGO:0450199.3IL10, IL4
29positive regulation of calcidiol 1-monooxygenase activityGO:0605599.3TNF, IFNG, IL1B
30extracellular matrix organizationGO:0301989.3TNF, MMP3, COL11A2, COL9A2, COL9A3
31positive regulation of membrane protein ectodomain proteolysisGO:0510449.3IL1B, IFNG, TNF
32positive regulation of MHC class II biosynthetic processGO:0453489.2IFNG, IL4, IL10
33positive regulation of isotype switching to IgG isotypesGO:0483049.2IFNG, IL4, IL2
34negative regulation of growth of symbiont in hostGO:0441309.1TNF, IFNG, IL10
35positive regulation of chemokine biosynthetic processGO:0450809.0TNF, IFNG, IL4, IL1B
36response to glucocorticoidGO:0513848.9TNF, IL1RN, IL10, IL6
37regulation of insulin secretionGO:0507968.9TNF, IFNG, IL1B
38positive regulation of T cell proliferationGO:0421028.8IL1B, IL6, IL4, IFNG
39immune responseGO:0069558.8IL1A, IL1B, IL4R, IL1RN, IL2, IL4
40defense response to protozoanGO:0428328.8IL6, IL4R, IL4, IFNG
41humoral immune responseGO:0069598.8IL6, IFNG, TNF
42cytokine-mediated signaling pathwayGO:0192218.8IFNG, IL6, IL1B, IL1A
43negative regulation of cell proliferationGO:0082858.7IL1A, IL1B, IL6, TNF, VDR
44inflammatory responseGO:0069548.7IL1A, IL1B, IL6, IL10, TNF
45positive regulation of nitric oxide biosynthetic processGO:0454298.7TNF, IFNG, IL6, IL1B
46positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.7TNF, IL4, IL10, IL6, IL1B
47positive regulation of transcription, DNA-templatedGO:0458938.6TNF, IL4, IL10, IL6, IL1B
48negative regulation of apoptotic processGO:0430668.5IL6, IL10, IL1RN, IL2, IL4
49response to drugGO:0424937.8TNF, IFNG, IL4, IL1RN, IL10, IL6
50positive regulation of transcription from RNA polymerase II promoterGO:0459446.6IL1A, VDR, TNF, IFNG, IL4, IL2

Molecular functions related to Intervertebral Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.6COL11A2, COL9A2, COL9A3
2interleukin-1 receptor bindingGO:0051499.3IL1A, IL1B, IL1RN
3growth factor activityGO:0080838.5IL6, IL10, IL2, IL4
4cytokine activityGO:0051256.6IL1A, IL1B, IL6, IL10, IL2, IL4

Products for genes affiliated with Intervertebral Disc Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Intervertebral Disc Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet