MCID: INT146
MIFTS: 59

Intervertebral Disc Disease

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Intervertebral Disc Disease

MalaCards integrated aliases for Intervertebral Disc Disease:

Name: Intervertebral Disc Disease 54 50 25 71 52
Intervertebral Disc Degeneration 50 25 42 69
Lumbar Disc Disease 54 71 52 69
Intervertebral Disc Disorder 25 29 69
Idd 50 25 71
Lumbar Disc Degeneration 54 71
Lumbar Disc Herniation 54 71
Intervertebral Disc Disease, Susceptibility to 13
Degeneration of Lumbar Intervertebral Disc 69
Abnormality of the Intervertebral Disk 29
Intervertebral Disk Degeneration 25
Intervertebral Disc Displacement 42
Intervertebral Disk Displacement 69
Disorder of Intervertebral Disc 25
Intervertebral Disk Disease 71
Degenerative Disc Disease 50
Discogenic Disorder 25
Discogenic Disease 25
Ldd 71
Ldh 71

Classifications:



External Ids:

OMIM 54 603932
ICD10 33 M51.2 M51.8

Summaries for Intervertebral Disc Disease

NIH Rare Diseases : 50 intervertebral disc disease (idd) is a common musculoskeletal condition that primarily affects the back. it is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. both environmental and genetic factors are thought to predispose an individual to developing the condition. treatment for idd may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion. last updated: 3/12/2012

MalaCards based summary : Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to cowden syndrome 1 and degenerative disc disease, and has symptoms including sciatica An important gene associated with Intervertebral Disc Disease is COL9A3 (Collagen Type IX Alpha 3 Chain), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Dexmedetomidine and Morphine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are cardiovascular system and limbs/digits/tail

UniProtKB/Swiss-Prot : 71 Intervertebral disc disease: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.

Genetics Home Reference : 25 Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine.

OMIM : 54
Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common musculoskeletal disorders, it has strong genetic determinants (Matsui et al., 1998; Battie et al., 1995; Sambrook et al., 1999). (603932)

Wikipedia : 72 An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the... more...

Related Diseases for Intervertebral Disc Disease

Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 cowden syndrome 1 11.5
2 degenerative disc disease 11.5
3 lactate dehydrogenase deficiency 11.5
4 lactate dehydrogenase b deficiency 11.5
5 spondyloepiphyseal dysplasia with congenital joint dislocations 11.0
6 osteochondritis dissecans, short stature, and early-onset osteoarthritis 11.0
7 benign familial mesial temporal lobe epilepsy 10.8 COL9A2 COL9A3
8 testicular seminoma 10.8
9 follicular lymphoma 10.8
10 glycogen storage disease xi 10.8
11 glycogen storage disease due to lactate dehydrogenase deficiency 10.8
12 drug rash with eosinophilia and systemic symptoms 10.5 IL6 MMP9
13 wagner syndrome 10.5 COL11A1 COL9A2
14 polyneuropathy in collagen vascular disease 10.5 IL6 MMP9
15 chromosomal disease 10.5 CILP COL9A2 COL9A3
16 cauda equina syndrome 10.5
17 immunodeficiency 27b, mycobacteriosis, ad 10.4 IL1B MMP9
18 oculomotor nerve paralysis 10.4 IL1B IL6
19 spondylolisthesis 10.4 COL9A2 COL9A3 THBS2
20 common peroneal nerve lesion 10.4 IL1B IL6
21 x-linked dominant intellectual disability-epilepsy syndrome 10.4 IL1B IL6
22 infancy electroclinical syndrome 10.4 IL1B IL6
23 lower clivus meningioma 10.4 IL1B MMP9
24 congenital nonspherocytic hemolytic anemia 10.4 IL1B IL6
25 upper gum cancer 10.4 IL1B IL6
26 bipolar i disorder 10.4 IL1B IL6
27 tricho onychic dysplasia 10.4 IL6 MMP9
28 acromesomelic dysplasia 10.4 ASPN COL11A1
29 tinea favosa 10.4 IL1B IL6
30 central nervous system leiomyosarcoma 10.4 IL1B IL6
31 influenza 10.4 IL1B MMP9
32 epstein-barr virus hepatitis 10.4 IL1A IL6
33 indolent myeloma 10.4 IL1B IL6
34 scoliosis, arachnodactyly, and blindness 10.4 IL1B IL6
35 subglottis neoplasm 10.4 IL1B IL6
36 bullous retinoschisis 10.3 IL1B IL6
37 carbuncle 10.3 IL1B IL6
38 vulvar sarcoma 10.3 IL1A IL6
39 gliosarcoma 10.3 IL1A IL1B
40 lung sarcoma 10.3 IL1A IL1B
41 dysmorphism-short stature-deafness-disorder of sex development syndrome 10.3 COL11A1 COL9A2 COL9A3
42 philophthalmiasis 10.3 IL1B IL6
43 charcot-marie-tooth disease type 5 10.3 COL11A1 COL9A2 COL9A3
44 syphilitic encephalitis 10.2 IL1B IL6
45 adult neuronal ceroid lipofuscinosis 10.2 IL6 VDR
46 intermediate uveitis 10.2 COL11A1 COL9A2 COL9A3
47 liver disease 10.2 IL1A IL1B
48 early-onset zonular cataract 10.2 IL1B IL6
49 mental retardation dysmorphism hypogonadism diabetes 10.2 IL1A IL1B
50 ethmoid sinus cancer 10.2 IL1B VDR

Comorbidity relations with Intervertebral Disc Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Heart Disease
Hypertension, Essential Ischemic Heart Disease
Osteoporosis

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to Intervertebral Disc Disease

Symptoms & Phenotypes for Intervertebral Disc Disease

Clinical features from OMIM:

603932

UMLS symptoms related to Intervertebral Disc Disease:


sciatica

MGI Mouse Phenotypes related to Intervertebral Disc Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 IL1A IL1B IL6 MMP11 MMP9 THBS2
2 limbs/digits/tail MP:0005371 9.63 THBS2 VDR ASPN COL11A1 COL9A2 MMP9
3 neoplasm MP:0002006 9.43 IL1A IL1B IL6 MMP11 MMP9 THBS2
4 skeleton MP:0005390 9.17 COL11A1 COL9A2 IL1B IL6 MMP9 THBS2

Drugs & Therapeutics for Intervertebral Disc Disease

Drugs for Intervertebral Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
4
Acetaminophen Approved Phase 4,Early Phase 1 103-90-2 1983
5
Ibuprofen Approved Phase 4 15687-27-1 3672
6
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
7
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
8
Menthol Approved Phase 4 2216-51-5 16666
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Norepinephrine Approved Phase 4 51-41-2 439260
11
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2
12 Analgesics Phase 4,Phase 3,Early Phase 1
13 Analgesics, Non-Narcotic Phase 4,Phase 3,Early Phase 1
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
17 Antirheumatic Agents Phase 4,Phase 3
18 Cyclooxygenase Inhibitors Phase 4,Phase 3
19 Adrenergic Agents Phase 4
20 Adrenergic Agonists Phase 4
21 Adrenergic alpha-2 Receptor Agonists Phase 4
22 Adrenergic alpha-Agonists Phase 4
23 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
24 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
25 Hypnotics and Sedatives Phase 4,Early Phase 1
26 Neurotransmitter Agents Phase 4,Early Phase 1
27 Analgesics, Opioid Phase 4,Phase 3,Early Phase 1
28 Narcotics Phase 4,Phase 3,Early Phase 1
29 Calcium, Dietary Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
30 Protective Agents Phase 4,Phase 3,Phase 2
31 Anti-Anxiety Agents Phase 4,Early Phase 1
32 Anticonvulsants Phase 4,Early Phase 1
33 Antioxidants Phase 4
34 Antipyretics Phase 4,Early Phase 1
35 calcium channel blockers Phase 4,Early Phase 1
36 Phosphodiesterase Inhibitors Phase 4
37 Platelet Aggregation Inhibitors Phase 4
38 Psychotropic Drugs Phase 4,Early Phase 1
39 Radiation-Protective Agents Phase 4
40 Tranquilizing Agents Phase 4,Early Phase 1
41 Vasodilator Agents Phase 4
42 Antidepressive Agents Phase 4
43 Dopamine Agents Phase 4
44 Duloxetine Hydrochloride Phase 4
45 Neurotransmitter Uptake Inhibitors Phase 4
46
Serotonin Phase 4 50-67-9 5202
47 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
48
Benzocaine Approved Phase 3,Phase 1 1994-09-7, 94-09-7 2337
49
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 5281106 54677470
50
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073

Interventional clinical trials:

(show top 50) (show all 253)

id Name Status NCT ID Phase Drugs
1 Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) Unknown status NCT02182843 Phase 4
2 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
3 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
4 CHARITE™ vs. ALIF 5-Year Follow-up Completed NCT00215332 Phase 4
5 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
6 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
7 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
8 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4 Intravenous infusion of Dexmedetomidine or 0.9% Saline
9 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
10 Barricaid EU Post Market Study for Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
11 Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody Fusion Recruiting NCT01549366 Phase 4
12 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
13 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
14 Pentoxifylline and Lumbar Radiculopathy Recruiting NCT03060434 Phase 4 Pentoxifylline Oral Tablet;Ibuprofen
15 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
16 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Active, not recruiting NCT02429908 Phase 4
17 Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF) Active, not recruiting NCT01016314 Phase 4
18 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Active, not recruiting NCT02535000 Phase 4 Duloxetine;Placebo
19 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
20 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
21 CARES Lumbar Artificial Disc Registry Terminated NCT02139527 Phase 4
22 Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease Unknown status NCT00589797 Phase 3
23 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
24 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
25 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
26 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
27 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
28 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
29 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
30 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
31 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
32 LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE Completed NCT00389597 Phase 3
33 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
34 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
35 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
36 Comparative Evaluation of Clinical Outcome of Degenerative Disc Disease Treated With the GelStix GelStix Study Recruiting NCT02763956 Phase 3
37 A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain Recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
38 A Study of SI-6603 in Patients With Lumbar Disc Herniation Active, not recruiting NCT02421601 Phase 3 Condoliase
39 A Study of SI-6603 in Patients With Lumbar Disc Herniation Active, not recruiting NCT01941563 Phase 3 Condoliase;placebo
40 Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels Active, not recruiting NCT00637156 Phase 3
41 Study of the Safety and Effectiveness of DIAM™ Spinal Stabilization System Versus Conservative Care Active, not recruiting NCT00456378 Phase 3
42 Prospective Study of Thoracolumbar Spinal Fusion Graft Active, not recruiting NCT02297256 Phase 3
43 Restore CLINICAL TRIAL Active, not recruiting NCT01609374 Phase 3
44 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
45 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
46 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
47 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
48 Qishe Pill for Cervical Radiculopathy Unknown status NCT01274936 Phase 2 Qishe Pill;Qishe Placebo
49 Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Lumbar Intervertebral Disc Degeneration Unknown status NCT01643681 Phase 1, Phase 2
50 Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease Completed NCT01513694 Phase 1, Phase 2

Search NIH Clinical Center for Intervertebral Disc Disease

Cochrane evidence based reviews: intervertebral disc degeneration

Genetic Tests for Intervertebral Disc Disease

Genetic tests related to Intervertebral Disc Disease:

id Genetic test Affiliating Genes
1 Intervertebral Disc Disorder 29
2 Abnormality of the Intervertebral Disk 29

Anatomical Context for Intervertebral Disc Disease

MalaCards organs/tissues related to Intervertebral Disc Disease:

39
Bone, Bone Marrow, Spinal Cord

Publications for Intervertebral Disc Disease

Articles related to Intervertebral Disc Disease:

(show top 50) (show all 98)
id Title Authors Year
1
Asthma and early herniated intervertebral disc disease. ( 28498027 )
2017
2
Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease. ( 28343922 )
2017
3
Retraction Notice: Lack of Relationship Between Occupational Workload and Microscopic Alterations in Lumbar Intervertebral Disc Disease. ( 28932331 )
2017
4
Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety and Preliminary Results. ( 28471303 )
2017
5
Complex Regional Pain Syndrome Caused by Lumbar Herniated Intervertebral Disc Disease. ( 27454281 )
2016
6
Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease. ( 26956825 )
2016
7
Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats. ( 26868632 )
2016
8
Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. ( 26743937 )
2016
9
The efficacy of interlaminar epidural steroid administration in multilevel intervertebral disc disease with chronic low back pain: a randomized, blinded, prospective Study. ( 27555486 )
2016
10
ICD-10: Intervertebral Disc Disease. ( 27514110 )
2016
11
DachsLife 2015: an investigation of lifestyle associations with the risk of intervertebral disc disease in Dachshunds. ( 27826450 )
2016
12
Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population. ( 28002589 )
2016
13
Genetic Alterations in Intervertebral Disc Disease. ( 27917384 )
2016
14
Thoracolumbar partial lateral corpectomy for the treatment of chronic intervertebral disc disease in 107 dogs. ( 26629329 )
2015
15
Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. ( 25694233 )
2015
16
Neurologic outcome after thoracolumbar partial lateral corpectomy for intervertebral disc disease in 72 dogs. ( 24484371 )
2014
17
Lack of relationship between occupational workload and microscopic alterations in lumbar intervertebral disc disease. ( 25136392 )
2014
18
Advancing the cellular and molecular therapy for intervertebral disc disease. ( 24993611 )
2014
19
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications. ( 25523328 )
2014
20
Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. ( 22805224 )
2013
21
The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. ( 23565773 )
2013
22
Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. ( 24381451 )
2013
23
Reoperation rate after surgery for lumbar herniated intervertebral disc disease: nationwide cohort study. ( 23023591 )
2013
24
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. ( 23702280 )
2013
25
Acute adverse events associated with ventral slot decompression in 546 dogs with cervical intervertebral disc disease. ( 23980621 )
2013
26
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. ( 24338460 )
2013
27
Intervertebral disc disease in dogs - part 1: a new histological grading scheme for classification of intervertebral disc degeneration in dogs. ( 22789628 )
2013
28
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. ( 22795604 )
2013
29
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. ( 23240963 )
2013
30
Comparison of computed tomography and myelography to a reference standard of computed tomographic myelography for evaluation of dogs with intervertebral disc disease. ( 22091972 )
2012
31
Magnetic resonance imaging diagnosis of intervertebral disc disease and myelomalacia in an American black bear (Ursus americanus). ( 22779249 )
2012
32
Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. ( 22286190 )
2012
33
Agreement between T2 and haste sequences in the evaluation of thoracolumbar intervertebral disc disease in dogs. ( 22168798 )
2012
34
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. ( 22912517 )
2012
35
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. ( 22250714 )
2012
36
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. ( 22105313 )
2012
37
Intervertebral disc disease in dogs. ( 20732594 )
2010
38
Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs. ( 20195068 )
2010
39
Acupuncture treatment for feline multifocal intervertebral disc disease. ( 19186087 )
2009
40
Continuous lumbar hemilaminectomy for intervertebral disc disease in an Amur tiger (Panthera tigris altaica). ( 18817014 )
2008
41
A critical evaluation of discography in patients with lumbar intervertebral disc disease. ( 18069067 )
2008
42
Detection of spinal cord compression in dogs with cervical intervertebral disc disease by magnetic resonance imaging. ( 18603629 )
2008
43
Future perspectives of cell-based therapy for intervertebral disc disease. ( 19005704 )
2008
44
Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease. ( 18520934 )
2008
45
Acute non-ambulatory tetraparesis attributable to cranial cervical intervertebral disc disease in a cat. ( 17560823 )
2007
46
Occupational and genetic risk factors associated with intervertebral disc disease. ( 17471097 )
2007
47
Re: Virtanen IM, Karppinen J, Taimela S, et al. Occupational and genetic risk factors associated with intervertebral disc disease. Spine 2007;32:1129-34. ( 18246021 )
2007
48
'Rumours of my death may have been greatly exaggerated': a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy. ( 17635120 )
2007
49
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. ( 15733644 )
2005
50
Surgical decompression in dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception: A retrospective study of 46 cases. ( 16108215 )
2005

Variations for Intervertebral Disc Disease

UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

71
id Symbol AA change Variation ID SNP ID
1 COL9A2 p.Gln326Trp VAR_012658 rs137853213

Expression for Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for Intervertebral Disc Disease

Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 COL11A1 COL9A2 COL9A3 MMP9
2
Show member pathways
12.29 ASPN COL11A1 COL9A2 COL9A3 MMP11 MMP9
3
Show member pathways
12.12 IL1A IL1B IL6
4 12.04 IL6 MMP11 MMP9
5 12.03 IL1A IL1B IL6
6
Show member pathways
12.01 IL1A IL1B IL6
7 12.01 IL1A IL1B IL6 VDR
8
Show member pathways
11.99 COL9A2 COL9A3 THBS2
9 11.95 IL1A IL1B MMP9
10 11.83 IL1B IL6 MMP9
11 11.81 IL1A IL1B IL6
12 11.77 IL1A IL1B IL6
13
Show member pathways
11.76 MMP11 MMP9 THBS2
14 11.75 IL1A IL1B IL6
15 11.71 IL1A IL1B IL6
16 11.7 IL1A IL1B IL6 MMP9
17 11.68 IL1A IL1B IL6
18 11.61 IL1A IL1B IL6
19 11.61 IL1A IL1B IL6 MMP9
20 11.51 IL1B IL6 MMP9
21 11.46 ASPN COL9A2 COL9A3
22 11.38 IL1A IL1B IL6
23 11.36 IL1B IL6 THBS2
24 11.33 IL1A IL1B IL6
25 11.17 IL1B IL6
26 11.15 IL1B IL6
27 11.15 IL1A IL1B IL6
28 11.12 IL1A IL1B IL6
29 11.06 IL1A IL1B IL6
30
Show member pathways
11.06 IL1A IL1B IL6 MMP9
31 11.04 IL1B MMP9
32 11.02 IL1A IL1B IL6
33 10.78 IL1B IL6
34 10.58 IL1A IL1B IL6 VDR
35 10.39 IL1A IL1B

GO Terms for Intervertebral Disc Disease

Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 CILP COL11A1 IL1A IL1B IL6 MMP9
2 endoplasmic reticulum lumen GO:0005788 9.67 COL11A1 COL9A2 COL9A3 IL6
3 extracellular region GO:0005576 9.65 ASPN COL11A1 COL9A2 COL9A3 IL1A IL1B
4 extracellular matrix GO:0031012 9.63 ASPN CILP COL11A1 MMP11 MMP9 THBS2
5 collagen trimer GO:0005581 9.58 COL11A1 COL9A2 COL9A3
6 collagen type IX trimer GO:0005594 9.26 COL9A2 COL9A3
7 proteinaceous extracellular matrix GO:0005578 9.23 ASPN CILP COL11A1 COL9A2 COL9A3 MMP11

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.78 IL1A IL1B IL6 VDR
2 positive regulation of gene expression GO:0010628 9.76 IL1A IL1B IL6 VDR
3 skeletal system development GO:0001501 9.67 COL9A2 MMP9 VDR
4 endodermal cell differentiation GO:0035987 9.54 COL11A1 MMP9
5 positive regulation of vascular endothelial growth factor production GO:0010575 9.52 IL1A IL1B
6 positive regulation of mitotic nuclear division GO:0045840 9.51 IL1A IL1B
7 collagen catabolic process GO:0030574 9.5 COL11A1 MMP11 MMP9
8 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.43 IL1A IL1B
9 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.4 IL1A IL1B
10 ectopic germ cell programmed cell death GO:0035234 9.37 IL1A IL1B
11 positive regulation of interleukin-6 production GO:0032755 9.33 IL1A IL1B IL6
12 fever generation GO:0001660 9.26 IL1A IL1B
13 cytokine-mediated signaling pathway GO:0019221 9.26 ASPN IL1A IL1B IL6
14 extracellular matrix organization GO:0030198 9.02 COL11A1 COL9A2 COL9A3 MMP11 MMP9

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 IL1A IL1B
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL9A2 COL9A3

Sources for Intervertebral Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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