MCID: INT060
MIFTS: 49

Intestinal Atresia malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Fetal diseases categories

Summaries for Intestinal Atresia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Intestinal atresia is a malformation where there is a narrowing or absence of a portion of the... more...

MalaCards: Intestinal Atresia is related to multiple intestinal atresia and imperforate anus. An important gene associated with Intestinal Atresia is TTC7A (tetratricopeptide repeat domain 7A), and among its related pathways are Digestion of dietary carbohydrate and Heart Development. The compounds Uridine diphosphate glucose and D-Glucose have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and brain, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Intestinal Atresia

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9Disease Ontology, 11DISEASES, 63UMLS, 36MeSH, 41NCIt
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Classifications:



Aliases & Descriptions:

intestinal atresia 9 11 63


External Ids:

Disease Ontology9 DOID:10486
MeSH36 D007409
NCIt41 C84790

Related Diseases for Intestinal Atresia

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18GeneCards, 19GeneDecks
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Diseases in the Multiple Intestinal Atresia family:

intestinal atresia

Diseases related to Intestinal Atresia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1multiple intestinal atresia31.3TREH
2imperforate anus30.3ARID3B, CPLX3
3diabetes mellitus30.2FABP2, MTHFR, SI
4gastroschisis10.6
5umbilical cord ulceration and intestinal atresia10.6
6intussusception10.5
7microcephaly10.3
8atresia of small intestine10.3
9hypoplastic pancreas-intestinal atresia-hypoplastic gallbalder syndrome10.3
10peritonitis10.2
11pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.2
12short bowel syndrome10.1
13intestinal volvulus10.1
14hirschsprung's disease10.1
15duodenitis10.1
16intestinal obstruction10.1
17colonic atresia10.1
18jejunal atresia10.1
19meconium ileus10.1
20ileus10.1
21omphalocele10.1
22riboflavin deficiency10.1MTHFR
23esophageal atresia10.1FGF10
24peters plus syndrome10.1FOXC1, PAX6
25glaucoma 3, primary congenital, d10.1FOXC1, PAX6
26axenfeld-rieger syndrome10.1FOXC1, PAX6
27aniridia10.1FOXC1, PAX6
28eye disease10.0FOXC1, PAX6
29developmental disabilities10.0FOXC1, PAX6
30cerebrovascular disease10.0MTHFR, FABP2
31congenital heart disease10.0MTHFR, FOXC1
32graft versus host disease10.0
33meckel's diverticulum10.0
34choanal atresia10.0
35neuronitis10.0
36angiodysplasia10.0
37hemochromatosis10.0
38neonatal diabetes mellitus10.0
39polyhydramnios10.0
40situs inversus10.0
41extrahepatic cholestasis10.0
42biliary atresia10.0
43cholestasis10.0
44glomerulonephritis10.0
45hepatitis10.0
46hypertension10.0
47severe combined immunodeficiency10.0
48thrombophilia10.0
49neonatal hemochromatosis10.0
5015q24 microdeletion syndrome10.0

Graphical network of the top 20 diseases related to Intestinal Atresia:



Diseases related to intestinal atresia

Symptoms for Intestinal Atresia

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Drugs & Therapeutics for Intestinal Atresia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Intestinal Atresia

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Anatomical Context for Intestinal Atresia

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34MalaCards
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MalaCards organs/tissues related to Intestinal Atresia:

34
Small intestine, Smooth muscle, Brain, Colon, Pancreas, Eye, Liver, Skin, Testes

Animal Models for Intestinal Atresia or affiliated genes

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38MGI
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Publications for Intestinal Atresia

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53PubMed
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Articles related to Intestinal Atresia:

(show top 50)    (show all 218)
idTitleAuthorsYear
1
Laparoscopy-assisted surgery for neonatal intestinal atresia and stenosis: a report of 35 cases. (23143134)
2012
2
Early colonization of intestinal bifidobacteria and lactobacilli in the postoperative neonates with congenital intestinal atresia. (21384062)
2011
3
Intestinal atresia and ectopia in a bovine fetus. (20926733)
2011
4
Intestinal atresia, encephalocele, and cardiac malformations in infants with 47,XXX: Expansion of the phenotypic spectrum and a review of the literature. (20160426)
2010
5
Is umbilical cord ulcer associated with congenital upper intestinal atresia so rare? Japanese case series and review of the literature. (20881370)
2010
6
Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn. (19887127)
2010
7
Intestinal atresia in association with gastroschisis: a 26-year review. (20676892)
2010
8
Catheter enterostomy and patch repair of the abdominal wall for gastroschisis with intestinal atresia: report of a case. (19639444)
2009
9
Different types of intestinal atresia in identical twins. (19040960)
2008
10
Morphological abnormalities in the innervation of the atretic segment of bowel in neonates with intestinal atresia. (17955249)
2007
11
A possible association between maternal glomerulonephritis and congenital intestinal atresia/stenosis--a population-based case-control study. (17569014)
2007
12
Pyloric obstruction, duodenal dilatation, and extrahepatic cholestasis: a neonatal triad suggesting multiple intestinal atresias. (17011287)
2006
13
Does small intestinal atresia affect epithelial protein expression in human newborns? (17130731)
2006
14
The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. (16410122)
2006
15
MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. (15821734)
2005
16
Association between multiple intestinal atresia and omphalocele: a case report. (11486351)
2001
17
Intestinal atresia: an end-to-end linear anastomotic technique. (11727065)
2001
18
Inherited thrombophilia: a possible cause of in utero vascular thrombosis in children with intestinal atresia. (11479844)
2001
19
Congenital small bowel diverticulosis and intestinal atresia: a rare association. (10770404)
2000
20
Intestinal atresia with gastroschisis: a selective approach to management. (10999689)
2000
21
A novel technique for correction of intestinal atresia at the ligament of Treitz. (10693695)
2000
22
Congenital intestinal atresia in a Kerry blue terrier. (10563244)
1999
23
Intestinal atresia and stenosis: a 25-year experience with 277 cases. (9605910)
1998
24
Mesenteric defects as a cause of intestinal volvulus without malrotation and as the possible primary etiology of intestinal atresia. (8786519)
1995
25
Intestinal bilious vomiting--an unusual presentation of intestinal atresia in the newborn. (7625312)
1994
26
Hereditary multiple intestinal atresia--ultrasound findings and outcome of pregnancy in an affected case. (8183838)
1994
27
Intrauterine intussusception as a cause of intestinal atresia. (1452326)
1992
28
Intestinal atresia: factors affecting survival. (2920000)
1989
29
Management of intestinal atresia complicating gastroschisis. (2525617)
1989
30
Myoelectric activity differences in acute and chronic models of lamb intestinal atresia. (3440912)
1987
31
Intestinal atresia and stenosis: a review comparing its morphology. (3962173)
1986
32
Intestinal atresia and stenosis: a review comparing its etiopathogenesis. (3962177)
1986
33
A 13q- syndrome with extensive intestinal atresia. (3993382)
1985
34
Intestinal atresia (report of 4 cases). (6481656)
1984
35
Operative mangement of intestinal atresia and stenosis based on pathologic findings. (480102)
1979
36
Gastroschisis complicated by intestinal atresia. (142311)
1977
37
Duodenojejunal atresia with "apple-peel" small bowel. A distinct form of intestinal atresia. (1251017)
1976
38
The pathogenesis of intestinal atresia. (1154228)
1975
39
Small intestinal atresia: the critical role of a functioning anastomosis. (4207350)
1974
40
Vomiting in utero with intestinal atresia. (4556279)
1972
41
Effect of changing concepts upon the diagnosis and management of intestinal atresia. (5538726)
1971
42
Small intestinal atresia. (5577678)
1971
43
Etiology and treatment of small intestinal atresia: analysis of a series of 127 jejunoileal atresias and comparison with 62 duodenal atresias. (5538950)
1971
44
Apple peel syndrome (congenital intestinal atresia): a family study of seven index patients. (5345098)
1969
45
The various patterns of intestinal atresia. (5676609)
1968
46
TOTAL INTESTINAL ATRESIA. (14146536)
1964
47
The occurrence of intestinal atresia in newborns with meconium ileus. The pathogenesis of an acquired anomaly. (13799829)
1960
48
Intestinal atresia: an attempt to relate location to embryologic processes. (14419162)
1959
49
Congenital intestinal atresia; a report of 17 cases. (13520228)
1958
50
The genesis of intestinal atresia. (13433397)
1957

Variations for Intestinal Atresia

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Expression for genes affiliated with Intestinal Atresia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Atresia

Search GEO for disease gene expression data for Intestinal Atresia.

Pathways for genes affiliated with Intestinal Atresia

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG
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Compounds for genes affiliated with Intestinal Atresia

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25HMDB, 46Novoseek, 12DrugBank, 62Tocris Bioscience
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Compounds related to Intestinal Atresia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Uridine diphosphate glucose2510.0SI, TREH
2D-Glucose259.8SI, TREH
3bromodeoxyuridine469.4FGF10, MYCN, PAX6
4riboflavin46 25 1211.1BLVRB, MTHFR
5carbon469.0TREH, SI, MTHFR, BLVRB
6alanine469.0TREH, SI, MTHFR, FABP2, PAX6
7testosterone46 62 25 1211.7FGF10, PLAGL1, MTHFR, BLVRB
8retinoic acid46 259.6PAX6, MYCN, FABP2, MTHFR, FGF10
9glucose468.3BLVRB, PAX6, ONECUT1, FABP2, SI, TREH

GO Terms for genes affiliated with Intestinal Atresia

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17Gene Ontology
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Cellular components related to Intestinal Atresia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.6FGF10, ARID3B, PLAGL1, FOXC1, RFX6, MYCN

Biological processes related to Intestinal Atresia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1type B pancreatic cell differentiationGO:00330910.1RFX6, PAX6
2polysaccharide digestionGO:04424510.1TREH, SI
3eye developmentGO:00165410.1PAX6, FOXC1
4pituitary gland developmentGO:0219839.8FGF10, PAX6
5lacrimal gland developmentGO:0328089.8FGF10, FOXC1, PAX6
6endocrine pancreas developmentGO:0310189.7RFX6, ONECUT1
7branching morphogenesis of an epithelial tubeGO:0487549.7MYCN, FGF10
8blood vessel remodelingGO:0019749.5FGF10, FOXC1
9spleen developmentGO:0485369.5FGF10, ONECUT1
10positive regulation of transcription, DNA-templatedGO:0458939.4FGF10, FOXC1, RFX6, PAX6
11positive regulation of transcription from RNA polymerase II promoterGO:0459448.5PAX6, ONECUT1, MYCN, FOXC1, PLAGL1, FGF10

Products for genes affiliated with Intestinal Atresia

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Sources for Intestinal Atresia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet