MCID: INT060
MIFTS: 39

Intestinal Atresia malady

Category: Gastrointestinal diseases

Aliases & Classifications for Intestinal Atresia

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Summaries for Intestinal Atresia

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Wikipedia:68 Intestinal atresia is a malformation where there is a narrowing or absence of a portion of the... more...

MalaCards based summary: Intestinal Atresia is related to imperforate anus and umbilical cord ulceration and intestinal atresia. An important gene associated with Intestinal Atresia is TTC7A (Tetratricopeptide Repeat Domain 7A), and among its related pathways are Heart Development and Regulation of beta-cell development. Affiliated tissues include liver, small intestine and endothelial, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Related Diseases for Intestinal Atresia

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Graphical network of the top 20 diseases related to Intestinal Atresia:



Diseases related to intestinal atresia

Symptoms for Intestinal Atresia

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Drugs & Therapeutics for Intestinal Atresia

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Drugs for Intestinal Atresia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bosentanapproved, investigationalPhase 2100147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
2Liver ExtractsPhase 23572
3Antihypertensive AgentsPhase 23618
4Endothelin Receptor AntagonistsPhase 2189
5
BilirubinPhase 2103635-65-45280352
Synonyms:
(4Z,15Z)-Bilirubin IXa
(Z,Z)-Bilirubin IXa
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoic acid
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
 
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Bilirubin
Bilirubin IX-alpha
Cholerythrin
Hematoidin
6Fat Emulsions, IntravenousPhase 229
7Hormone AntagonistsPhase 1, Phase 210002
8HormonesPhase 1, Phase 211748
9Glucagon-Like Peptide 1Phase 1, Phase 2620
10IncretinsPhase 1, Phase 21326
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 1, Phase 29988
12Gastrointestinal AgentsPhase 1, Phase 26401
13glucagonPhase 1, Phase 2379
14Soy BeanNutraceuticalPhase 2455
15Omega 3 Fatty AcidNutraceuticalPhase 2912
16
VancomycinapprovedPhase 13051404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
LS-161387
 
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin Hydrochloride
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
17Anti-Bacterial AgentsPhase 19140
18Anti-Infective AgentsPhase 117220
19
Neomycinapproved421404-04-28378
Synonyms:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
11025-81-3
119-04-0
1393-86-8
1404-04-2
1405-10-3 (sulfate (salt))
4-18-00-07476 (Beilstein Handbook Reference)
72131_FLUKA
AB00443887
AC1L1QVH
Actilin
Actiline
Antibiotic 10676
Antibiotic produced by Streptomyces decaris. Neomycin B
Antibiotique
BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG
BDG-(1-4)NEB-(5-1)RIB-(3-1)NED
BPBio1_000326
BRN 0101621
BSPBio_000296
C01737
C23H46N6O13
C25H50N6O13
CCRIS 5462
CHEBI:7508
CID8378
Caswell No. 595
D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy
D05140
DB00452
DB00994
EINECS 204-292-2
EINECS 215-766-3
EPA Pesticide Chemical Code 006303
Endomixin
Enterfram
Fradiomycin
Fradiomycin B
Fradiomycinum
Framicetina
Framicetina [INN-Spanish]
Framycetin
Framycetin (INN)
Framycetin [INN:BAN:DCF]
Framycetine
Framycetine [INN-French]
Framycetinum
Framycetinum [INN-Latin]
Framygen
 
Fraquinol
HMS2089P15
HSDB 3242
LS-96091
LS-96095
MolPort-003-938-736
Myacine
Myacyne
Mycifradin
Myciguent
N1142_SIGMA
NCGC00179612-01
NEOMYCIN AND POLYMYXIN B SULFATES
NEOMYCIN B
NEOMYCIN SULFATE
NMY
Neo-Fradin
Neo-Rx
Neo-fradin
Neobiotic
Neobrettin
Neolate
Neomas
Neomcin
Neomicina
Neomicina [DCIT]
Neomin
Neomycin B Sulfate
Neomycin B sulfate
Neomycin Sulfate
Neomycin Sulphate
Neomycin solution
Neomycine
Neomycine [INN-French]
Neomycinum
Neomycinum [INN-Latin]
Nivemycin
PIMAVECORT
Prestwick3_000158
ST075177
Soframycin
Soframycin Ophthalmic
Soframycine
Theraplusplus Plus
Tuttomycin
UNII-4BOC774388
UNII-I16QD7X297
USAF CB-19
VONAMYCIN
Vonamycin powder V
neomycin
20Vitamins3857
21Trace Elements3900
22Pharmaceutical Solutions7004
23Micronutrients3901
24Alpha 1-Antitrypsin87
25Protein C Inhibitor85
26Bile Acids and Salts86
27alanineNutraceutical106
28lysineNutraceutical77
29glutamineNutraceutical144
30AcidophilusNutraceutical482
31ColaNutraceutical1768

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology.CompletedNCT01292551Phase 2
2Compassionate Use of Omegaven in ChildrenRecruitingNCT02370251Phase 2
3Safety and Dosing Study of Glucagon-like Peptide 2 (GLP-2) in Infants and Children With Intestinal FailureTerminatedNCT01573286Phase 1, Phase 2
4Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With VancomycinCompletedNCT01322386Phase 1
5Treating Primary Sclerosing Cholangitis and Biliary Atresia With VancomycinRecruitingNCT02137668Phase 1
6Determination of Lysine Requirement in the Parenterally Fed NeonateCompletedNCT00779753
7Esophageal Atresia: Metaplasia, BarrettCompletedNCT02495051
8Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome InfantsCompletedNCT01576003
9Modified Perfusion for Neonatal Aortic Arch ReconstructionCompletedNCT00490256
10Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai PortoenterostomyCompletedNCT00166868
11Survival With Own Liver of Conventional Versus Laparoscopic Kasai for Biliary AtresiaCompletedNCT01063699
12Trail to Investigate the Effectiveness of CoSeal in Reducing Adhesions Following the Kasai Hepatoportoenterostomy for Biliary AtresiaRecruitingNCT01745991
13Molecular Genetics of Heterotaxy and Related Congenital Heart DefectsRecruitingNCT02432079
143D High Resolution Anorectal Manometry in Children After Surgery for Anorectal DisordersRecruitingNCT02296008
15Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)RecruitingNCT00571272
16Long-term Outcome in Patients With Anorectal MalformationsNot yet recruitingNCT02624232
17Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in InfantsTerminatedNCT01062815

Search NIH Clinical Center for Intestinal Atresia


Cochrane evidence based reviews: intestinal atresia

Genetic Tests for Intestinal Atresia

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Anatomical Context for Intestinal Atresia

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MalaCards organs/tissues related to Intestinal Atresia:

33
Liver, Small intestine, Endothelial, Prostate, Heart, Lung, Breast

Animal Models for Intestinal Atresia or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Atresia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0FGF10, FOXC1, PLAGL1, TTC7A
2MP:00053678.7FABP2, FGF10, FOXC1, TTC7A
3MP:00053888.4FGF10, FOXC1, HOXA2, PLAGL1
4MP:00053817.9FGF10, FOXC1, HOXA2, RFX6, TTC7A
5MP:00053857.9FGF10, FOXC1, HOXA2, PLAGL1, TTC7A
6MP:00053786.6FABP2, FGF10, FOXC1, HOXA2, PLAGL1, RFX6

Publications for Intestinal Atresia

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Articles related to Intestinal Atresia:

(show top 50)    (show all 234)
idTitleAuthorsYear
1
Histomorphological Features of Intestinal Atresia and its Clinical Correlation. (26674207)
2015
2
Correction: the complex surgical management of the first case of severe combined immunodeficiency and multiple intestinal atresias surviving after the fourth year of life. (25866737)
2015
3
Tetratricopeptide repeat domain 7A (TTC7A) mutation in a newborn with multiple intestinal atresia and combined immunodeficiency. (24931897)
2014
4
Multiple intestinal atresia with combined immune deficiency. (25268403)
2014
5
Population-based study of esophageal and small intestinal atresia/stenosis. (24730728)
2014
6
Laparoscopy-assisted surgery for neonatal intestinal atresia and stenosis: a report of 35 cases. (23143134)
2012
7
Early colonization of intestinal bifidobacteria and lactobacilli in the postoperative neonates with congenital intestinal atresia. (21384062)
2011
8
Intestinal atresia and ectopia in a bovine fetus. (20926733)
2011
9
Intestinal atresia, encephalocele, and cardiac malformations in infants with 47,XXX: Expansion of the phenotypic spectrum and a review of the literature. (20160426)
2010
10
Is umbilical cord ulcer associated with congenital upper intestinal atresia so rare? Japanese case series and review of the literature. (20881370)
2010
11
Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn. (19887127)
2010
12
Catheter enterostomy and patch repair of the abdominal wall for gastroschisis with intestinal atresia: report of a case. (19639444)
2009
13
Different types of intestinal atresia in identical twins. (19040960)
2008
14
Morphological abnormalities in the innervation of the atretic segment of bowel in neonates with intestinal atresia. (17955249)
2007
15
A possible association between maternal glomerulonephritis and congenital intestinal atresia/stenosis--a population-based case-control study. (17569014)
2007
16
Pyloric obstruction, duodenal dilatation, and extrahepatic cholestasis: a neonatal triad suggesting multiple intestinal atresias. (17011287)
2006
17
Does small intestinal atresia affect epithelial protein expression in human newborns? (17130731)
2006
18
The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. (16410122)
2006
19
MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. (15821734)
2005
20
Association between multiple intestinal atresia and omphalocele: a case report. (11486351)
2001
21
Intestinal atresia: an end-to-end linear anastomotic technique. (11727065)
2001
22
Inherited thrombophilia: a possible cause of in utero vascular thrombosis in children with intestinal atresia. (11479844)
2001
23
Congenital small bowel diverticulosis and intestinal atresia: a rare association. (10770404)
2000
24
Intestinal atresia with gastroschisis: a selective approach to management. (10999689)
2000
25
Congenital intestinal atresia in a Kerry blue terrier. (10563244)
1999
26
Intestinal atresia and stenosis: a 25-year experience with 277 cases. (9605910)
1998
27
Mesenteric defects as a cause of intestinal volvulus without malrotation and as the possible primary etiology of intestinal atresia. (8786519)
1995
28
Intestinal bilious vomiting--an unusual presentation of intestinal atresia in the newborn. (7625312)
1994
29
Hereditary multiple intestinal atresia--ultrasound findings and outcome of pregnancy in an affected case. (8183838)
1994
30
Myoelectric activity differences in acute and chronic models of lamb intestinal atresia. (3440912)
1987
31
Intestinal atresia and stenosis: a review comparing its morphology. (3962173)
1986
32
Intestinal atresia and stenosis: a review comparing its etiopathogenesis. (3962177)
1986
33
A 13q- syndrome with extensive intestinal atresia. (3993382)
1985
34
Intestinal atresia (report of 4 cases). (6481656)
1984
35
Operative mangement of intestinal atresia and stenosis based on pathologic findings. (480102)
1979
36
Gastroschisis complicated by intestinal atresia. (142311)
1977
37
Duodenojejunal atresia with "apple-peel" small bowel. A distinct form of intestinal atresia. (1251017)
1976
38
The pathogenesis of intestinal atresia. (1154228)
1975
39
Small intestinal atresia: the critical role of a functioning anastomosis. (4207350)
1974
40
Vomiting in utero with intestinal atresia. (4556279)
1972
41
Effect of changing concepts upon the diagnosis and management of intestinal atresia. (5538726)
1971
42
Small intestinal atresia. (5577678)
1971
43
Etiology and treatment of small intestinal atresia: analysis of a series of 127 jejunoileal atresias and comparison with 62 duodenal atresias. (5538950)
1971
44
Apple peel syndrome (congenital intestinal atresia): a family study of seven index patients. (5345098)
1969
45
The various patterns of intestinal atresia. (5676609)
1968
46
TOTAL INTESTINAL ATRESIA. (14146536)
1964
47
The occurrence of intestinal atresia in newborns with meconium ileus. The pathogenesis of an acquired anomaly. (13799829)
1960
48
Intestinal atresia: an attempt to relate location to embryologic processes. (14419162)
1959
49
Congenital intestinal atresia; a report of 17 cases. (13520228)
1958
50
The genesis of intestinal atresia. (13433397)
1957

Variations for Intestinal Atresia

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Expression for genes affiliated with Intestinal Atresia

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Search GEO for disease gene expression data for Intestinal Atresia.

Pathways for genes affiliated with Intestinal Atresia

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GO Terms for genes affiliated with Intestinal Atresia

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Biological processes related to Intestinal Atresia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood vessel remodelingGO:000197410.0FGF10, FOXC1
2positive regulation of transcription, DNA-templatedGO:00458939.2FGF10, FOXC1, RFX6
3positive regulation of transcription from RNA polymerase II promoterGO:00459448.5FGF10, FOXC1, PLAGL1, RFX6

Molecular functions related to Intestinal Atresia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:00442129.6FOXC1, RFX6

Sources for Intestinal Atresia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet