MCID: INT060
MIFTS: 49

Intestinal Atresia malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Fetal diseases categories
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Summaries for Intestinal Atresia

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Wikipedia:65 Intestinal atresia is a malformation where there is a narrowing or absence of a portion of the... more...

MalaCards based summary: Intestinal Atresia is related to multiple intestinal atresia and imperforate anus. An important gene associated with Intestinal Atresia is TTC7A (tetratricopeptide repeat domain 7A), and among its related pathways are Digestion of dietary carbohydrate and Heart Development. The compounds Uridine diphosphate glucose and D-Glucose have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and brain, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Intestinal Atresia

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Intestinal Atresia, Aliases & Descriptions:

Name: Intestinal Atresia 8 10 62


Classifications:



External Ids:

Disease Ontology8 DOID:10486
MeSH34 D007409
NCIt39 C84790

Related Diseases for Intestinal Atresia

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Diseases in the Multiple Intestinal Atresia family:

intestinal atresia

Diseases related to Intestinal Atresia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1multiple intestinal atresia31.9TREH
2imperforate anus30.6ARID3B, CPLX3
3diabetes mellitus30.2FABP2, MTHFR, SI
4gastroschisis10.6
5umbilical cord ulceration and intestinal atresia10.6
6intussusception10.5
7microcephaly10.3
8riboflavin deficiency10.3MTHFR
9esophageal atresia10.3FGF10
10atresia of small intestine10.3
11hypoplastic pancreas-intestinal atresia-hypoplastic gallbalder syndrome10.3
12peters plus syndrome10.3FOXC1, PAX6
13glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.3FOXC1, PAX6
14axenfeld-rieger syndrome10.3FOXC1, PAX6
15peritonitis10.2
16jejunal atresia10.2
17pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.2
18aniridia10.2FOXC1, PAX6
19spiradenoma10.2FOXC1, PAX6
20developmental disabilities10.2FOXC1, PAX6
21jejunoileitis10.1
22short bowel syndrome10.1
23intestinal volvulus10.1
24hirschsprung's disease10.1
25duodenitis10.1
26intestinal obstruction10.1
27colonic atresia10.1
28meconium ileus10.1
29ileus10.1
30omphalocele10.1
31cerebrovascular disease10.1MTHFR, FABP2
32glomerulonephritis10.0
33graft versus host disease10.0
34hepatitis10.0
35hypertension10.0
36pulmonary hypertension10.0
37severe combined immunodeficiency10.0
38angiodysplasia10.0
39hemochromatosis10.0
40situs inversus10.0
41extrahepatic cholestasis10.0
42biliary atresia10.0
43meckel's diverticulum10.0
44choanal atresia10.0
45neonatal diabetes mellitus10.0
46neuronitis10.0
47polyhydramnios10.0
48cholestasis10.0
49esophagitis10.0
50thrombophilia10.0

Graphical network of the top 20 diseases related to Intestinal Atresia:



Diseases related to intestinal atresia

Symptoms for Intestinal Atresia

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Drugs & Therapeutics for Intestinal Atresia

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Drug clinical trials:

Search ClinicalTrials for Intestinal Atresia

Search NIH Clinical Center for Intestinal Atresia

Genetic Tests for Intestinal Atresia

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Anatomical Context for Intestinal Atresia

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MalaCards organs/tissues related to Intestinal Atresia:

32
Small intestine, Smooth muscle, Brain, Colon, Eye, Liver, Pancreas, Skin, Testes

Animal Models for Intestinal Atresia or affiliated genes

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Publications for Intestinal Atresia

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Articles related to Intestinal Atresia:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Tetratricopeptide repeat domain 7A (TTC7A) mutation in a newborn with multiple intestinal atresia and combined immunodeficiency. (24931897)
2014
2
Multiple intestinal atresia with combined immune deficiency. (25268403)
2014
3
Population-based study of esophageal and small intestinal atresia/stenosis. (24730728)
2014
4
Laparoscopy-assisted surgery for neonatal intestinal atresia and stenosis: a report of 35 cases. (23143134)
2012
5
Early colonization of intestinal bifidobacteria and lactobacilli in the postoperative neonates with congenital intestinal atresia. (21384062)
2011
6
Intestinal atresia and ectopia in a bovine fetus. (20926733)
2011
7
Intestinal atresia, encephalocele, and cardiac malformations in infants with 47,XXX: Expansion of the phenotypic spectrum and a review of the literature. (20160426)
2010
8
Is umbilical cord ulcer associated with congenital upper intestinal atresia so rare? Japanese case series and review of the literature. (20881370)
2010
9
Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn. (19887127)
2010
10
Intestinal atresia in association with gastroschisis: a 26-year review. (20676892)
2010
11
Catheter enterostomy and patch repair of the abdominal wall for gastroschisis with intestinal atresia: report of a case. (19639444)
2009
12
Different types of intestinal atresia in identical twins. (19040960)
2008
13
Morphological abnormalities in the innervation of the atretic segment of bowel in neonates with intestinal atresia. (17955249)
2007
14
A possible association between maternal glomerulonephritis and congenital intestinal atresia/stenosis--a population-based case-control study. (17569014)
2007
15
Pyloric obstruction, duodenal dilatation, and extrahepatic cholestasis: a neonatal triad suggesting multiple intestinal atresias. (17011287)
2006
16
Does small intestinal atresia affect epithelial protein expression in human newborns? (17130731)
2006
17
The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. (16410122)
2006
18
MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. (15821734)
2005
19
Association between multiple intestinal atresia and omphalocele: a case report. (11486351)
2001
20
Intestinal atresia: an end-to-end linear anastomotic technique. (11727065)
2001
21
Inherited thrombophilia: a possible cause of in utero vascular thrombosis in children with intestinal atresia. (11479844)
2001
22
Congenital small bowel diverticulosis and intestinal atresia: a rare association. (10770404)
2000
23
Intestinal atresia with gastroschisis: a selective approach to management. (10999689)
2000
24
Congenital intestinal atresia in a Kerry blue terrier. (10563244)
1999
25
Intestinal atresia and stenosis: a 25-year experience with 277 cases. (9605910)
1998
26
Mesenteric defects as a cause of intestinal volvulus without malrotation and as the possible primary etiology of intestinal atresia. (8786519)
1995
27
Intestinal bilious vomiting--an unusual presentation of intestinal atresia in the newborn. (7625312)
1994
28
Hereditary multiple intestinal atresia--ultrasound findings and outcome of pregnancy in an affected case. (8183838)
1994
29
Intestinal atresia: factors affecting survival. (2920000)
1989
30
Myoelectric activity differences in acute and chronic models of lamb intestinal atresia. (3440912)
1987
31
Intestinal atresia and stenosis: a review comparing its morphology. (3962173)
1986
32
Intestinal atresia and stenosis: a review comparing its etiopathogenesis. (3962177)
1986
33
A 13q- syndrome with extensive intestinal atresia. (3993382)
1985
34
Intestinal atresia (report of 4 cases). (6481656)
1984
35
Operative mangement of intestinal atresia and stenosis based on pathologic findings. (480102)
1979
36
Gastroschisis complicated by intestinal atresia. (142311)
1977
37
Duodenojejunal atresia with "apple-peel" small bowel. A distinct form of intestinal atresia. (1251017)
1976
38
The pathogenesis of intestinal atresia. (1154228)
1975
39
Small intestinal atresia: the critical role of a functioning anastomosis. (4207350)
1974
40
Vomiting in utero with intestinal atresia. (4556279)
1972
41
Effect of changing concepts upon the diagnosis and management of intestinal atresia. (5538726)
1971
42
Small intestinal atresia. (5577678)
1971
43
Etiology and treatment of small intestinal atresia: analysis of a series of 127 jejunoileal atresias and comparison with 62 duodenal atresias. (5538950)
1971
44
Apple peel syndrome (congenital intestinal atresia): a family study of seven index patients. (5345098)
1969
45
The various patterns of intestinal atresia. (5676609)
1968
46
TOTAL INTESTINAL ATRESIA. (14146536)
1964
47
The occurrence of intestinal atresia in newborns with meconium ileus. The pathogenesis of an acquired anomaly. (13799829)
1960
48
Intestinal atresia: an attempt to relate location to embryologic processes. (14419162)
1959
49
Congenital intestinal atresia; a report of 17 cases. (13520228)
1958
50
The genesis of intestinal atresia. (13433397)
1957

Variations for Intestinal Atresia

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Expression for genes affiliated with Intestinal Atresia

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Expression patterns in normal tissues for genes affiliated with Intestinal Atresia

Search GEO for disease gene expression data for Intestinal Atresia.

Pathways for genes affiliated with Intestinal Atresia

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Compounds for genes affiliated with Intestinal Atresia

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Sources:
24HMDB, 44Novoseek, 11DrugBank, 61Tocris Bioscience
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Compounds related to Intestinal Atresia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Uridine diphosphate glucose2410.0SI, TREH
2D-Glucose249.8SI, TREH
3bromodeoxyuridine449.4FGF10, MYCN, PAX6
4riboflavin44 24 1111.1BLVRB, MTHFR
5carbon449.0TREH, SI, MTHFR, BLVRB
6alanine449.0TREH, SI, MTHFR, FABP2, PAX6
7testosterone44 61 24 1111.7FGF10, PLAGL1, MTHFR, BLVRB
8retinoic acid44 249.6PAX6, MYCN, FABP2, MTHFR, FGF10
9glucose448.3BLVRB, PAX6, ONECUT1, FABP2, SI, TREH

GO Terms for genes affiliated with Intestinal Atresia

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Cellular components related to Intestinal Atresia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.6FGF10, ARID3B, PLAGL1, FOXC1, RFX6, MYCN

Biological processes related to Intestinal Atresia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1type B pancreatic cell differentiationGO:00330910.1RFX6, PAX6
2polysaccharide digestionGO:04424510.1TREH, SI
3eye developmentGO:00165410.1PAX6, FOXC1
4pituitary gland developmentGO:0219839.8FGF10, PAX6
5lacrimal gland developmentGO:0328089.8FGF10, FOXC1, PAX6
6endocrine pancreas developmentGO:0310189.7RFX6, ONECUT1
7branching morphogenesis of an epithelial tubeGO:0487549.7MYCN, FGF10
8blood vessel remodelingGO:0019749.5FGF10, FOXC1
9spleen developmentGO:0485369.5FGF10, ONECUT1
10positive regulation of transcription, DNA-templatedGO:0458939.4FGF10, FOXC1, RFX6, PAX6
11positive regulation of transcription from RNA polymerase II promoterGO:0459448.5PAX6, ONECUT1, MYCN, FOXC1, PLAGL1, FGF10

Products for genes affiliated with Intestinal Atresia

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Sources for Intestinal Atresia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet