MCID: INT060
MIFTS: 42

Intestinal Atresia malady

Gastrointestinal category

Summaries for Intestinal Atresia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Intestinal atresia is a malformation where there is a narrowing or absence of a portion of the... more...

MalaCards: Intestinal Atresia is related to neonatal diabetes mellitus and imperforate anus. An important gene associated with Intestinal Atresia is FABP2 (fatty acid binding protein 2, intestinal), and among its related pathways are Digestion of dietary carbohydrate and Regulation of beta-cell development. The compounds bromodeoxyuridine and riboflavin have been mentioned in the context of this disorder. Affiliated tissues include brain, smooth muscle and small intestine, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Aliases & Classifications for Intestinal Atresia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

intestinal atresia 8 10 61


External Ids:

Disease Ontology8 DOID:10486
MeSH35 D007409
NCIt40 C84790

Related Diseases for Intestinal Atresia

Sources:
17GeneCards, 18GeneDecks
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Diseases in the multiple intestinal atresia family:

intestinal atresia

Diseases related to Intestinal Atresia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal diabetes mellitus30.1PLAGL1
2imperforate anus30.1CPLX3, ARID3B
3multiple intestinal atresia10.7
4gastroschisis10.6
5umbilical cord ulceration and intestinal atresia10.5
6intussusception10.4
7microcephaly10.3
8n syndrome10.3
9micro syndrome10.3
10atresia of small intestine10.2
11frias syndrome10.2
12pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.2
13intestinal volvulus10.1
14short bowel syndrome10.1
15short syndrome10.1
16jejunal atresia10.1
17brown syndrome10.1
18colonic atresia10.1
19duodenal atresia10.1
20meconium ileus10.1
21ileus10.1
22omphalocele10.1
23iris hypoplasia and glaucoma10.0FOXC1
24peters plus syndrome10.0PAX6
25glaucoma 3, primary congenital, d10.0FOXC1, PAX6
26axenfeld-rieger syndrome10.0PAX6, FOXC1
27mental retardation10.0FOXC1, PAX6
28aniridia10.0PAX6, FOXC1
29eye disease10.0FOXC1, PAX6
30esophageal atresia10.0FGF10
31graft versus host disease10.0
32extrahepatic cholestasis10.0
33biliary atresia10.0
34hemochromatosis10.0
35angiodysplasia10.0
36polyhydramnios10.0
37situs inversus10.0
38thrombophilia10.0
39neonatal hemochromatosis10.0
4015q24 microdeletion syndrome10.0
41prune belly syndrome10.0
42acardia10.0
43arthrogryposis multiplex congenita neurogenic type10.0
44encephalocele10.0
45feingold syndrome10.0
46campomelia cumming type10.0
47hardikar syndrome10.0
48novak syndrome10.0
49twin twin transfusion syndrome10.0
50single median maxillary central incisor10.0

Graphical network of the top 20 diseases related to Intestinal Atresia:



Diseases related to intestinal atresia

Clinical Features for Intestinal Atresia

Drugs & Therapeutics for Intestinal Atresia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intestinal Atresia

Drug clinical trials:

Search ClinicalTrials for Intestinal Atresia

Search NIH Clinical Center for Intestinal Atresia

Search CenterWatch for Intestinal Atresia

Genetic Tests for Intestinal Atresia

Anatomical Context for Intestinal Atresia

Sources:
33MalaCards
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MalaCards organs/tissues related to Intestinal Atresia:

33
Brain, Smooth muscle, Small intestine, Colon, Liver, Pancreas, Skin, T cells, Fetal brain, Fetal liver

Animal Models for Intestinal Atresia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Intestinal Atresia

Sources:
51PubMed
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Articles related to Intestinal Atresia:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Acquired Ileal Atresia Induced by Adhesive Intestinal Obstruction. (24248986)
2013
2
Fetal MRI of hereditary multiple intestinal atresia with postnatal correlation. (24096803)
2013
3
Gastroschisis associated with an omphalocele and intestinal atresia. (23917330)
2013
4
Long-term outcomes for infants with intestinal atresia studied at Children's National Medical Center. (23666458)
2013
5
Prenatal intestinal obstruction affects the myenteric plexus and causes functional bowel impairment in fetal rat experimental model of intestinal atresia. (23667464)
2013
6
Multiple intestinal anastomoses to avoid short bowel syndrome and stimulate bowel maturity in type IV multiple intestinal atresia and necrotizing enterocolitis. (22424368)
2012
7
Hereditary multiple intestinal atresia (HMIA) with severe combined immunodeficiency (SCID): a case report of two siblings and review of the literature on MIA, HMIA and HMIA with immunodeficiency over the last 50 years. (22715199)
2011
8
Is umbilical cord ulcer associated with congenital upper intestinal atresia so rare? Japanese case series and review of the literature. (20881370)
2010
9
Intestinal atresia in association with gastroschisis: a 26-year review. (20676892)
2010
10
Intrauterine intussusception: a rare cause of intestinal atresia. (19853768)
2009
11
A further example of a distinctive autosomal recessive syndrome comprising neonatal diabetes mellitus, intestinal atresias and gall bladder agenesis. (18512226)
2008
12
Exclusion of a PAX6, FOXC1, PITX2, and MYCN mutation in another patient with apple peel intestinal atresia, ocular anomalies and microcephaly and review of the literature. (18203155)
2008
13
Association of rare intestinal malformations: colonic atresia and intestinal neuronal dysplasia. (18165207)
2007
14
A possible association between maternal glomerulonephritis and congenital intestinal atresia/stenosis--a population-based case-control study. (17569014)
2007
15
Intestinal atresia of co-twin after spontaneous cessation of blood flow through an acardiac twin. (17728970)
2007
16
Does small intestinal atresia affect epithelial protein expression in human newborns? (17130731)
2006
17
MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. (15821734)
2005
18
Serial transverse enteroplasty in intestinal atresia management. (15750915)
2005
19
Intestinal atresia with segmental musculature and neural defect. (16080924)
2005
20
Fetal intestinal obstruction induces alteration of enteric nervous system development in human intestinal atresia. (15496609)
2004
21
Double intestinal atresia in imperforate anus: a diagnostic conundrum for paediatric surgeons. (14719516)
2004
22
Multiple intestinal atresia with apple peel syndrome: successful treatment by five end-to-end anastomoses, jejunostomy, and transanastomotic silicone stent. (12891506)
2003
23
The occurrence of unusual smooth muscle bundles expressing alpha-smooth muscle actin in human intestinal atresia. (12596095)
2003
24
Use of intraluminal stents in multiple intestinal atresia. (12407564)
2002
25
"Apple-peel" intestinal atresia, ocular anomalies, and microcephaly syndrome: brain magnetic resonance imaging study. (12116257)
2002
26
A novel technique for correction of intestinal atresia at the ligament of Treitz. (10693695)
2000
27
Intestinal atresia and stenosis: a 25-year experience with 277 cases. (9605910)
1998
28
Pyloric atresia associated with intestinal atresia. (9269987)
1997
29
Umbilical cord ulceration and intestinal atresia. (9119106)
1996
30
Surgical aspects of intestinal atresia in 58 calves. (7747387)
1995
31
Intestinal bilious vomiting--an unusual presentation of intestinal atresia in the newborn. (7625312)
1994
32
Increased risk of small intestinal atresia among twins in the United States. (8019630)
1994
33
Umbilical cord ulceration in association with intestinal atresia in a child with deletion 13q and Hirschsprung's disease. (7820720)
1994
34
Mesenteric defects as a cause of intestinal volvulus without malrotation and as the possible primary etiology of intestinal atresia. (7807321)
1994
35
Intrauterine intussusception as a cause of intestinal atresia. (1452326)
1992
36
Congenital intestinal atresia. (2257399)
1990
37
Intestinal atresia: factors affecting survival. (2920000)
1989
38
Multiple intestinal atresia and amyoplasia congenita in four unrelated infants: a new association. (3701551)
1986
39
Intestinal atresia. (6618564)
1983
40
The pathogenesis of intestinal atresia. (1154228)
1975
41
Intestinal atresia in fetal dogs produced by localized ligation of mesenteric vessels. (1202181)
1975
42
Vomiting in utero with intestinal atresia. (4556279)
1972
43
Small intestinal atresia. (5577678)
1971
44
JEJUNAL ATRESIA WITH INTESTINAL APLASIA. STRANGULATION OF THE INTESTINE IN THE EXTRAEMBRYONIC COELOM OF THE BELLY STALK. (14114319)
1964
45
SURGICAL ADJUNCT IN THE TREATMENT OF INTESTINAL ATRESIA. (14082829)
1964
46
Treatment of intestinal atresia: Roux-en-Y anastomosis and enterostomy. (14485576)
1962
47
Intestinal atresia. A clinical analysis of twenty-six cases, 1951-1961. (14492040)
1962
48
Management of intestinal atresia at the Los Angeles Children's Hospital. (13736886)
1961
49
Congenital intestinal atresia and stenosis in the newborn. Observations on its pathogenesis and treatment. (14418455)
1959
50
Farber's test in the diagnosis of congenital intestinal atresia. (20272708)
1947

Genetic Variations for Intestinal Atresia

Expression for genes affiliated with Intestinal Atresia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Atresia

Search GEO for disease gene expression data for Intestinal Atresia.

Pathways for genes affiliated with Intestinal Atresia

Sources:
54Reactome, 30KEGG, 52QIAGEN
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Pathways related to Intestinal Atresia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SI, TREH
2
Hide members
9.4ONECUT1, PAX6
39.1ONECUT1, PAX6, FOXC1

Compounds for genes affiliated with Intestinal Atresia

Sources:
45Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Intestinal Atresia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bromodeoxyuridine459.5PAX6, FGF10, MYCN
2riboflavin45 11 2411.2MTHFR, BLVRB
3retinoic acid45 2410.0PAX6, FGF10, MYCN, MTHFR, FABP2
4alanine458.8FABP2, MTHFR, TREH, SI, PAX6
5carbon458.8SI, BLVRB, TREH, MTHFR
6glucose457.8FABP2, TREH, BLVRB, SI, PAX6, ONECUT1

GO Terms for genes affiliated with Intestinal Atresia

Sources:
16Gene Ontology
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Cellular components related to Intestinal Atresia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.4RFX6, ARID3B, RBFOX1, MYCN, BLVRB, FGF10

Biological processes related to Intestinal Atresia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1eye developmentGO:0016549.9PAX6, FOXC1
2polysaccharide digestionGO:0442459.8SI, TREH
3lacrimal gland developmentGO:0328089.8PAX6, FGF10, FOXC1
4pituitary gland developmentGO:0219839.5PAX6, FGF10
5spleen developmentGO:0485369.3ONECUT1, FGF10
6positive regulation of transcription, DNA-dependentGO:0458938.6FOXC1, FGF10, PAX6, ONECUT1, RFX6
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.5FOXC1, FGF10, PLAGL1, PAX6, ONECUT1

Products for genes affiliated with Intestinal Atresia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intestinal Atresia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet