MCID: INT060
MIFTS: 43

Intestinal Atresia malady

Gastrointestinal diseases category

Summaries for Intestinal Atresia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intestinal atresia is a malformation where there is a narrowing or absence of a portion of the... more...

MalaCards: Intestinal Atresia is related to neonatal diabetes mellitus and imperforate anus. An important gene associated with Intestinal Atresia is FABP2 (fatty acid binding protein 2, intestinal), and among its related pathways are Digestion of dietary carbohydrate and Regulation of beta-cell development. The compounds bromodeoxyuridine and riboflavin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and colon, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Aliases & Classifications for Intestinal Atresia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intestinal atresia 8 10 60


External Ids:

Disease Ontology8 DOID:10486
MeSH34 D007409
NCIt39 C84790

Related Diseases for Intestinal Atresia

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17GeneCards, 18GeneDecks
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Diseases in the Multiple Intestinal Atresia family:

intestinal atresia

Diseases related to Intestinal Atresia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal diabetes mellitus30.1PLAGL1
2imperforate anus30.1CPLX3, ARID3B
3diabetes mellitus30.1FABP2, MTHFR, SI
4multiple intestinal atresia10.7
5gastroschisis10.6
6umbilical cord ulceration and intestinal atresia10.5
7intussusception10.4
8microcephaly10.3
9intestinal disease10.3
10atresia of small intestine10.3
11intestinal obstruction10.2
12peritonitis10.2
13pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.2
14intestinal volvulus10.1
15short bowel syndrome10.1
16hirschsprung's disease10.1
17duodenitis10.1
18intestinal perforation10.1
19jejunal atresia10.1
20colonic atresia10.1
21frias syndrome10.1
22iris hypoplasia and glaucoma10.0FOXC1
23peters plus syndrome10.0PAX6
24glaucoma 3, primary congenital, d10.0FOXC1, PAX6
25axenfeld-rieger syndrome10.0PAX6, FOXC1
26mental retardation10.0FOXC1, PAX6
27aniridia10.0PAX6, FOXC1
28eye disease10.0FOXC1, PAX6
29esophageal atresia10.0FGF10
30type 2 diabetes mellitus10.0FABP2, MTHFR, SI, ONECUT1
31breast cancer10.0PLAGL1, MYCN, MTHFR, FOXC1
32graft versus host disease10.0
33extrahepatic cholestasis10.0
34biliary atresia10.0
35meckel's diverticulum10.0
36hemochromatosis10.0
37angiodysplasia10.0
38neuronitis10.0
39polyhydramnios10.0
40situs inversus10.0
41choanal atresia10.0
42cholestasis10.0
43duodenal obstruction10.0
44glomerulonephritis10.0
45hepatitis10.0
46hypertension10.0
47pancreas disease10.0
48severe combined immunodeficiency10.0
49thrombophilia10.0
50neonatal hemochromatosis10.0

Graphical network of the top 20 diseases related to Intestinal Atresia:



Diseases related to intestinal atresia

Clinical Features for Intestinal Atresia

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Drugs & Therapeutics for Intestinal Atresia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Intestinal Atresia

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Anatomical Context for Intestinal Atresia

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32MalaCards
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MalaCards organs/tissues related to Intestinal Atresia:

32
Small intestine, Smooth muscle, Colon, Brain, Pancreas, Eye, Liver, Skin, Testes

Animal Models for Intestinal Atresia or affiliated genes

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36MGI
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Publications for Intestinal Atresia

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50PubMed
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Articles related to Intestinal Atresia:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Intestinal atresia occurring in association with placental fetal thrombotic vasculopathy: a case report with literature review. (22989172)
2013
2
Apple-peel intestinal atresia: enteroplasty for intestinal lengthening and primary anastomosis. (23845656)
2013
3
Brown bowel syndrome: a rare and often overlooked complication of intestinal atresia. (24404548)
2013
4
Outcomes of early versus late intestinal operations in patients with gastroschisis and intestinal atresia: results from a prospective national database. (24094951)
2013
5
Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin. (23084212)
2012
6
Gastroschisis with intestinal atresia--predictive value of antenatal diagnosis and outcome of postnatal treatment. (22325384)
2012
7
A rare case of duodenal atresia with apple-peel configuration of the small intestine and malrotation. (21553369)
2011
8
Medical management of motility disorders in patients with intestinal failure: a focus on necrotizing enterocolitis, gastroschisis, and intestinal atresia. (21843732)
2011
9
Concordant intestinal atresia in two pairs of monozygotic twins. (23705091)
2011
10
Transposition of the great arteries, interrupted inferior vena cava and intestinal atresia: a new association? (19117800)
2009
11
Hydrometrocolpos from a low vaginal atresia: an uncommon cause of neonatal intestinal and urinary obstruction. (19858664)
2008
12
Small intestinal atresia in a defined population: occurrence, prenatal diagnosis and survival. (17994616)
2007
13
A comprehensive analysis of 51 neonates with congenital intestinal atresia. (17603708)
2007
14
Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome. (15592663)
2004
15
Notochord-gut failure of detachment and intestinal atresia. (15103493)
2004
16
Epidemiological investigations of an outbreak of intestinal atresia in two Israeli dairy herds. (12576722)
2003
17
In utero sonographic findings in a fetus with a hereditary multiple intestinal atresia. (12051458)
2002
18
Intestinal atresia: an end-to-end linear anastomotic technique. (11727065)
2001
19
Intestinal atresia associated with twin-twin transfusion syndrome. (11431792)
2001
20
Congenital small bowel diverticulosis and intestinal atresia: a rare association. (10770404)
2000
21
Umbilical cord ulcer: a serious in utero complication of intestinal atresia. (10833382)
2000
22
Amyoplasia congenita and intestinal atresia: a common etiology. (10626531)
1999
23
Abnormalities of enteric neurons, intestinal pacemaker cells, and smooth muscle in human intestinal atresia. (10549748)
1999
24
40 years' review of intestinal atresia. (11601247)
1999
25
Fetal varicella syndrome: association with multiple hepatic calcifications and intestinal atresia. (9285750)
1997
26
Descriptive epidemiology of small intestinal atresia, Atlanta, Georgia. (8303613)
1993
27
Mucosal morphology in experimental intestinal atresia: studies in the chick embryo. (2023081)
1991
28
Congenital intestinal atresia: correction. (2009432)
1991
29
Intestinal atresia in calves: 22 cases (1978-1988). (2777696)
1989
30
Myoelectric activity differences in acute and chronic models of lamb intestinal atresia. (3440912)
1987
31
Congenital segmental dilatation of small intestine with oesophageal atresia and duodenal atresia in a premature infant. (3687236)
1987
32
Intestinal atresia and stenosis: a review comparing its morphology. (3962173)
1986
33
Intestinal atresia. Current concepts of pathogenesis, pathophysiology, and operative management. (6614657)
1983
34
Gastroschisis complicated by intestinal atresia. (6454776)
1981
35
Operative mangement of intestinal atresia and stenosis based on pathologic findings. (480102)
1979
36
Duodenojejunal atresia with "apple-peel" small bowel. A distinct form of intestinal atresia. (1251017)
1976
37
Intestinal atresia dur to intrauterine intussusception: analysis of 24 cases in Japan. (1171171)
1975
38
Small intestinal atresia: the critical role of a functioning anastomosis. (4207350)
1974
39
Extensive intramural intestinal calcification in a newborn with intestinal atresia. Case report. (4695912)
1973
40
Experimental intestinal atresia in the rabbit fetus. Sequential pathological studies. (5081731)
1972
41
Changing concepts in the management of intestinal atresia. (5449607)
1970
42
Apple peel syndrome (congenital intestinal atresia): a family study of seven index patients. (5345098)
1969
43
The various patterns of intestinal atresia. (5676609)
1968
44
ON CONGENITAL INTESTINAL ATRESIA: REPORT OF A CASE AND OBSERVATIONS ON ITS PATHOGENESIS. (14285130)
1965
45
ORIGIN OF INTESTINAL ATRESIA OF NEWBORN. (14184516)
1964
46
Intestinal atresia or stenosis in the newborn associated with fibrocystic disease of the pancreas. (13723755)
1961
47
Congenital intestinal atresia; a report of 17 cases. (13520228)
1958
48
The genesis of intestinal atresia. (13433397)
1957
49
Operative management of congenital intestinal atresia. (13249343)
1955
50
Congenital Intestinal Atresia. (17859333)
1949

Genetic Variations for Intestinal Atresia

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Expression for genes affiliated with Intestinal Atresia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Atresia

Search GEO for disease gene expression data for Intestinal Atresia.

Pathways for genes affiliated with Intestinal Atresia

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53Reactome, 29KEGG, 51QIAGEN
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Pathways related to Intestinal Atresia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SI, TREH
2
Hide members
9.4ONECUT1, PAX6
39.1ONECUT1, PAX6, FOXC1

Compounds for genes affiliated with Intestinal Atresia

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Intestinal Atresia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bromodeoxyuridine449.5PAX6, FGF10, MYCN
2riboflavin44 11 2411.2MTHFR, BLVRB
3retinoic acid44 2410.0PAX6, FGF10, MYCN, MTHFR, FABP2
4alanine448.8FABP2, MTHFR, TREH, SI, PAX6
5carbon448.8SI, BLVRB, TREH, MTHFR
6glucose447.8FABP2, TREH, BLVRB, SI, PAX6, ONECUT1

GO Terms for genes affiliated with Intestinal Atresia

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16Gene Ontology
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Cellular components related to Intestinal Atresia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.4RFX6, ARID3B, RBFOX1, MYCN, BLVRB, FGF10

Biological processes related to Intestinal Atresia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1eye developmentGO:0016549.9PAX6, FOXC1
2polysaccharide digestionGO:0442459.8SI, TREH
3lacrimal gland developmentGO:0328089.8PAX6, FGF10, FOXC1
4pituitary gland developmentGO:0219839.5PAX6, FGF10
5spleen developmentGO:0485369.3ONECUT1, FGF10
6positive regulation of transcription, DNA-dependentGO:0458938.6FOXC1, FGF10, PAX6, ONECUT1, RFX6
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.5FOXC1, FGF10, PLAGL1, PAX6, ONECUT1

Products for genes affiliated with Intestinal Atresia

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Sources for Intestinal Atresia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet