MCID: INT060
MIFTS: 43

Intestinal Atresia malady

Gastrointestinal diseases category

Summaries for Intestinal Atresia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intestinal atresia is a malformation where there is a narrowing or absence of a portion of the... more...

MalaCards: Intestinal Atresia is related to neonatal diabetes mellitus and imperforate anus. An important gene associated with Intestinal Atresia is FABP2 (fatty acid binding protein 2, intestinal), and among its related pathways are Digestion of dietary carbohydrate and Regulation of beta-cell development. The compounds bromodeoxyuridine and riboflavin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and colon, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Aliases & Classifications for Intestinal Atresia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intestinal atresia 8 10 60


External Ids:

Disease Ontology8 DOID:10486
MeSH34 D007409
NCIt39 C84790

Related Diseases for Intestinal Atresia

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17GeneCards, 18GeneDecks
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Diseases in the Multiple Intestinal Atresia family:

intestinal atresia

Diseases related to Intestinal Atresia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal diabetes mellitus30.1PLAGL1
2imperforate anus30.1CPLX3, ARID3B
3diabetes mellitus30.1FABP2, MTHFR, SI
4multiple intestinal atresia10.7
5gastroschisis10.6
6umbilical cord ulceration and intestinal atresia10.5
7intussusception10.4
8microcephaly10.3
9intestinal disease10.3
10atresia of small intestine10.3
11intestinal obstruction10.2
12peritonitis10.2
13pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.2
14intestinal volvulus10.1
15short bowel syndrome10.1
16hirschsprung's disease10.1
17duodenitis10.1
18intestinal perforation10.1
19jejunal atresia10.1
20colonic atresia10.1
21frias syndrome10.1
22iris hypoplasia and glaucoma10.0FOXC1
23peters plus syndrome10.0PAX6
24glaucoma 3, primary congenital, d10.0FOXC1, PAX6
25axenfeld-rieger syndrome10.0PAX6, FOXC1
26mental retardation10.0FOXC1, PAX6
27aniridia10.0PAX6, FOXC1
28eye disease10.0FOXC1, PAX6
29esophageal atresia10.0FGF10
30type 2 diabetes mellitus10.0FABP2, MTHFR, SI, ONECUT1
31breast cancer10.0PLAGL1, MYCN, MTHFR, FOXC1
32graft versus host disease10.0
33extrahepatic cholestasis10.0
34biliary atresia10.0
35meckel's diverticulum10.0
36hemochromatosis10.0
37angiodysplasia10.0
38neuronitis10.0
39polyhydramnios10.0
40situs inversus10.0
41choanal atresia10.0
42cholestasis10.0
43duodenal obstruction10.0
44glomerulonephritis10.0
45hepatitis10.0
46hypertension10.0
47pancreas disease10.0
48severe combined immunodeficiency10.0
49thrombophilia10.0
50neonatal hemochromatosis10.0

Graphical network of the top 20 diseases related to Intestinal Atresia:



Diseases related to intestinal atresia

Clinical Features for Intestinal Atresia

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Drugs & Therapeutics for Intestinal Atresia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Intestinal Atresia

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Genetic Tests for Intestinal Atresia

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Anatomical Context for Intestinal Atresia

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32MalaCards
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MalaCards organs/tissues related to Intestinal Atresia:

32
Small intestine, Smooth muscle, Colon, Brain, Pancreas, Testes, Skin, Liver, Eye

Animal Models for Intestinal Atresia or affiliated genes

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36MGI
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Publications for Intestinal Atresia

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50PubMed
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Articles related to Intestinal Atresia:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Fetal MRI of hereditary multiple intestinal atresia with postnatal correlation. (24096803)
2013
2
Gastroschisis associated with an omphalocele and intestinal atresia. (23917330)
2013
3
Long-term outcomes for infants with intestinal atresia studied at Children's National Medical Center. (23666458)
2013
4
Prenatal intestinal obstruction affects the myenteric plexus and causes functional bowel impairment in fetal rat experimental model of intestinal atresia. (23667464)
2013
5
Sonographic diagnosis of fetal intestinal volvulus with ileal atresia: a case report. (22585388)
2013
6
Multiple intestinal anastomoses to avoid short bowel syndrome and stimulate bowel maturity in type IV multiple intestinal atresia and necrotizing enterocolitis. (22424368)
2012
7
Hereditary multiple intestinal atresia (HMIA) with severe combined immunodeficiency (SCID): a case report of two siblings and review of the literature on MIA, HMIA and HMIA with immunodeficiency over the last 50 years. (22715199)
2011
8
Intrauterine intussusception: a rare cause of intestinal atresia. (19853768)
2009
9
Different types of intestinal atresia in identical twins. (19040960)
2008
10
A further example of a distinctive autosomal recessive syndrome comprising neonatal diabetes mellitus, intestinal atresias and gall bladder agenesis. (18512226)
2008
11
Exclusion of a PAX6, FOXC1, PITX2, and MYCN mutation in another patient with apple peel intestinal atresia, ocular anomalies and microcephaly and review of the literature. (18203155)
2008
12
A possible association between maternal glomerulonephritis and congenital intestinal atresia/stenosis--a population-based case-control study. (17569014)
2007
13
Solitary intestinal fibromatosis associated with congenital ileal atresia. (18022453)
2007
14
The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. (16410122)
2006
15
Serial transverse enteroplasty in intestinal atresia management. (15750915)
2005
16
Fetal intestinal obstruction induces alteration of enteric nervous system development in human intestinal atresia. (15496609)
2004
17
Double intestinal atresia in imperforate anus: a diagnostic conundrum for paediatric surgeons. (14719516)
2004
18
Multiple intestinal atresia with apple peel syndrome: successful treatment by five end-to-end anastomoses, jejunostomy, and transanastomotic silicone stent. (12891506)
2003
19
Use of intraluminal stents in multiple intestinal atresia. (12407564)
2002
20
"Apple-peel" intestinal atresia, ocular anomalies, and microcephaly syndrome: brain magnetic resonance imaging study. (12116257)
2002
21
A novel technique for correction of intestinal atresia at the ligament of Treitz. (10693695)
2000
22
Congenital intestinal atresia in a Kerry blue terrier. (10563244)
1999
23
Intestinal atresia and stenosis: a 25-year experience with 277 cases. (9605910)
1998
24
Pyloric atresia associated with intestinal atresia. (9269987)
1997
25
Umbilical cord ulceration and intestinal atresia. (9119106)
1996
26
Mesenteric defects as a cause of intestinal volvulus without malrotation and as the possible primary etiology of intestinal atresia. (8786519)
1995
27
Surgical aspects of intestinal atresia in 58 calves. (7747387)
1995
28
Intestinal bilious vomiting--an unusual presentation of intestinal atresia in the newborn. (7625312)
1994
29
Hereditary multiple intestinal atresia--ultrasound findings and outcome of pregnancy in an affected case. (8183838)
1994
30
Increased risk of small intestinal atresia among twins in the United States. (8019630)
1994
31
Mesenteric defects as a cause of intestinal volvulus without malrotation and as the possible primary etiology of intestinal atresia. (7807321)
1994
32
Delayed presentation of intestinal atresia and intussusception--a case report and literature review. (8292584)
1993
33
Intrauterine intussusception as a cause of intestinal atresia. (1452326)
1992
34
Gastroschisis and intestinal atresia. (1832714)
1991
35
Congenital intestinal atresia. (2257399)
1990
36
Management of intestinal atresia complicating gastroschisis. (2525617)
1989
37
Intestinal atresia and stenosis: a review comparing its etiopathogenesis. (3962177)
1986
38
Multiple intestinal atresia and amyoplasia congenita in four unrelated infants: a new association. (3701551)
1986
39
A 13q- syndrome with extensive intestinal atresia. (3993382)
1985
40
Intestinal atresia and stenosis: analysis of survival in 120 cases. (4049243)
1985
41
Intestinal atresia. (6618564)
1983
42
Intestinal atresia in fetal dogs produced by localized ligation of mesenteric vessels. (1202181)
1975
43
Small intestinal atresia. (5577678)
1971
44
SURGICAL ADJUNCT IN THE TREATMENT OF INTESTINAL ATRESIA. (14082829)
1964
45
Intestinal atresia. A clinical analysis of twenty-six cases, 1951-1961. (14492040)
1962
46
Management of intestinal atresia at the Los Angeles Children's Hospital. (13736886)
1961
47
Intestinal atresia: an attempt to relate location to embryologic processes. (14419162)
1959
48
Congenital intestinal atresia. (14351730)
1955
49
Congenital duodenal atresia with malrotation of the intestine; a case successfully treated by duodeno-jejunostomy. (15405584)
1950
50
Farber's test in the diagnosis of congenital intestinal atresia. (20272708)
1947

Genetic Variations for Intestinal Atresia

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Expression for genes affiliated with Intestinal Atresia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Atresia

Search GEO for disease gene expression data for Intestinal Atresia.

Pathways for genes affiliated with Intestinal Atresia

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53Reactome, 29KEGG, 51QIAGEN
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Pathways related to Intestinal Atresia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SI, TREH
2
Hide members
9.4ONECUT1, PAX6
39.1ONECUT1, PAX6, FOXC1

Compounds for genes affiliated with Intestinal Atresia

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Intestinal Atresia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bromodeoxyuridine449.5PAX6, FGF10, MYCN
2riboflavin44 11 2411.2MTHFR, BLVRB
3retinoic acid44 2410.0PAX6, FGF10, MYCN, MTHFR, FABP2
4alanine448.8FABP2, MTHFR, TREH, SI, PAX6
5carbon448.8SI, BLVRB, TREH, MTHFR
6glucose447.8FABP2, TREH, BLVRB, SI, PAX6, ONECUT1

GO Terms for genes affiliated with Intestinal Atresia

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16Gene Ontology
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Cellular components related to Intestinal Atresia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.4RFX6, ARID3B, RBFOX1, MYCN, BLVRB, FGF10

Biological processes related to Intestinal Atresia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1eye developmentGO:0016549.9PAX6, FOXC1
2polysaccharide digestionGO:0442459.8SI, TREH
3lacrimal gland developmentGO:0328089.8PAX6, FGF10, FOXC1
4pituitary gland developmentGO:0219839.5PAX6, FGF10
5spleen developmentGO:0485369.3ONECUT1, FGF10
6positive regulation of transcription, DNA-dependentGO:0458938.6FOXC1, FGF10, PAX6, ONECUT1, RFX6
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.5FOXC1, FGF10, PLAGL1, PAX6, ONECUT1

Products for genes affiliated with Intestinal Atresia

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Sources for Intestinal Atresia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet