MCID: INT068
MIFTS: 59

Intestinal Disease

Categories: Infectious diseases, Gastrointestinal diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Intestinal Disease

Summaries for Intestinal Disease

Disease Ontology : 12 A gastrointestinal system disease that is located in the intestine.

MalaCards based summary : Intestinal Disease, also known as intestinal diseases, is related to short bowel syndrome and cyclosporiasis, and has symptoms including anal or rectal pain, constipation and diarrhea. An important gene associated with Intestinal Disease is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Akt Signaling and Toll-Like receptor Signaling Pathways. The drugs Infliximab and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Related Diseases for Intestinal Disease

Diseases in the Intestinal Disease family:

Chronic Intestinal Failure

Diseases related to Intestinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
id Related Disease Score Top Affiliating Genes
1 short bowel syndrome 31.6 GCG GHRL IL6
2 cyclosporiasis 30.7 IL10 IL6 TNF
3 lymphoma 30.6 IL10 IL17A IL1B IL6 TLR9 TNF
4 asthma 29.3 AREG IL10 IL17A IL1B IL6 TLR9
5 alpha-heavy chain disease 11.2
6 pure autonomic failure 11.1 IL10 TNF
7 autoimmune oophoritis 11.0 MPO TNF
8 acute ackee fruit intoxication 11.0 IL10 TNF
9 crohn's disease 11.0
10 acute vascular insufficiency of intestine 11.0 TLR9 TNF TP53
11 smarca4-deficient sarcoma of thorax 11.0 IL6 TNF
12 malignant melanocytic peripheral nerve sheath tumor of mediastinum 11.0 SDC1 TLR9 TP53
13 petrous apex meningioma 11.0 CRP SDC1 TNF
14 peroneal nerve paralysis 11.0 IL10 IL6 TLR9
15 epulis 11.0 IL1B TNF TRPV1
16 tularemia 11.0 IL10 TLR9 TNF
17 oculo-cerebral dysplasia 11.0 IL17A NOD2 TLR9
18 amyotrophic lateral sclerosis type 10 11.0 IL1B NOD2 TNF
19 acute cholinergic dysautonomia 11.0 TNF TP53
20 ethmoid sinus adenocarcinoma 11.0 IL10 IL6 TNF
21 functional gastric disease 11.0 CRP NOD2 TNF
22 epstein-barr virus hepatitis 11.0 CRP IL6 TNF
23 cystoisosporiasis 11.0
24 scrotal carcinoma 11.0 IL1B IL6 TNF
25 yao syndrome 11.0 IL1B NOD2 TNF
26 membranoproliferative glomerulonephritis 11.0 NOD2 TLR9 TNF
27 senile reticular retinal degeneration 11.0 IL10 IL1B TNF
28 infancy electroclinical syndrome 11.0 IL10 IL1B IL6
29 cryptogenic organizing pneumonia 11.0 CRP IL17A TRPV1
30 phlyctenulosis 11.0 IL10 IL6 TNF
31 eyelid neoplasm 11.0 IL10 TLR9 TRPV1
32 upper gum cancer 11.0 IL1B IL6 TNF
33 bipolar i disorder 10.9 IL1B IL6 TNF
34 acute monoblastic leukemia 10.9 IL10 NOD2 TNF
35 retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities 10.9 GHRL IL1B TP53 TRPV1
36 cicatricial lagophthalmos 10.9 CRP IL6 TNF
37 hypolipoproteinemia 10.9 CRP MPO TP53
38 primary biliary cirrhosis 10.9 IL10 IL6 TNF
39 collagenopathy type 2 alpha 1 10.9 CRP IL6
40 pityriasis rosea 10.9 IL6 TNF TRPV1
41 testicular infarct 10.9 IL1B TLR9 TNF
42 queensland tick typhus 10.9 CRP IL6 NOD2
43 indolent myeloma 10.9 IL1B IL6 TNF
44 x-linked dominant intellectual disability-epilepsy syndrome 10.9 CRP IL1B IL6
45 hepadnavirus infection 10.9 IL10 IL6 TNF
46 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.9 IL1B IL6 TNF
47 female reproductive system disease 10.9 IL17A NOD2 TNF
48 islet cell tumor 10.9 CRP IL6 TNF
49 alkhurma hemorrhagic fever 10.9 IL10 IL17A TNF
50 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.9 CRP IL10 IL6

Comorbidity relations with Intestinal Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Esophagitis
Heart Disease Intestinal Obstruction
Ischemic Heart Disease Paralytic Ileus

Graphical network of the top 20 diseases related to Intestinal Disease:



Diseases related to Intestinal Disease

Symptoms & Phenotypes for Intestinal Disease

UMLS symptoms related to Intestinal Disease:


anal or rectal pain, constipation, diarrhea, signs and symptoms, digestive

GenomeRNAi Phenotypes related to Intestinal Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 TNF TP53 IL10 IL17A IL1B MPO
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 TNF TP53 IL10 IL17A IL1B MPO

MGI Mouse Phenotypes related to Intestinal Disease:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.35 IL6 MPO NOD2 SDC1 TLR9 TNF
2 cardiovascular system MP:0005385 10.29 MPO TNF TP53 TRPV1 AREG ATG16L1
3 cellular MP:0005384 10.24 ATG16L1 EDNRB HPS4 IL10 IL6 NOD2
4 digestive/alimentary MP:0005381 10.22 IL10 IL17A IL6 NOD2 TLR9 TNF
5 hematopoietic system MP:0005397 10.22 AREG ATG16L1 HPS4 IL10 IL17A IL1B
6 growth/size/body region MP:0005378 10.21 TRPV1 AREG ATG16L1 CORT EDNRB HPS4
7 endocrine/exocrine gland MP:0005379 10.2 AREG ATG16L1 CORT EDNRB GHRL IL10
8 immune system MP:0005387 10.2 AREG ATG16L1 CRP EDNRB IL10 IL17A
9 mortality/aging MP:0010768 9.97 AREG ATG16L1 EDNRB IL10 IL17A IL1B
10 integument MP:0010771 9.96 AREG EDNRB HPS4 IL10 IL1B IL6
11 neoplasm MP:0002006 9.56 IL6 SDC1 TNF TP53 TRPV1 EDNRB
12 vision/eye MP:0005391 9.23 AREG ATG16L1 EDNRB HPS4 IL10 IL6

Drugs & Therapeutics for Intestinal Disease

Drugs for Intestinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1230)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
2
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
3
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
4
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
5
Rifabutin Approved Phase 4,Phase 3 72559-06-9 6323490
6
Hydrocortisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 50-23-7 5754 657311
7
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
9
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
12
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
13
Dexlansoprazole Approved Phase 4,Phase 3,Phase 2 138530-94-6, 103577-45-3 9578005
14
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
15
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2 103577-45-3 3883
16
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
17
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Early Phase 1 6493-05-6 4740
18
Erythromycin Approved, Vet_approved Phase 4,Phase 2,Phase 3 114-07-8 12560
19
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
20
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61825-94-3 5310940 9887054 43805 6857599
21
Tegafur Approved Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7 5386
22
Bisacodyl Approved Phase 4,Phase 3,Phase 2,Phase 1 603-50-9
23
Ertapenem Approved, Investigational Phase 4,Phase 2,Early Phase 1 153832-46-3 150610
24
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
25
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
26
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
27
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
28
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
29
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
30
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
31
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
32
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 443-48-1 4173
33
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3 117976-89-3 5029
34
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
35
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
36
Glipizide Approved Phase 4 29094-61-9 3478
37
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
38
Reboxetine Approved, Investigational Phase 4 98769-81-4, 71620-89-8 123628 65856
39
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
40
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 2216-51-5 16666
41
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 465-65-6 5284596
42
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
43
Ibuprofen Approved Phase 4,Phase 3,Phase 2 15687-27-1 3672
44
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 73590-58-6 4594
45
Albendazole Approved, Vet_approved Phase 4,Phase 3 54965-21-8 2082
46
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 437-38-7 3345
47
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
48
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 2078-54-8 4943
49
Rosiglitazone Approved, Investigational Phase 4,Phase 1,Phase 2 122320-73-4 77999
50
Azathioprine Approved Phase 4,Phase 2,Phase 3,Phase 1 446-86-6 2265

Interventional clinical trials:

(show top 50) (show all 8357)

id Name Status NCT ID Phase Drugs
1 Single-Operator Versus Dual-Operator Double-balloon Endoscopy in Patients With Small-Bowel Disorders Unknown status NCT01184690 Phase 4
2 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
3 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
4 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
5 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
6 Double- Versus Single-balloon Enteroscopy for Obscure Small-bowel Bleeding Unknown status NCT01176864 Phase 4
7 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
8 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4 Vitamin D;Placebo
9 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
10 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
11 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
12 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
13 Lactobacillus Reuteri in Children With Constipation Unknown status NCT01388712 Phase 4
14 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
15 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
16 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
17 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
18 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
19 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
20 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
21 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
22 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
23 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
24 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
25 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4 VSL#3
26 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
27 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
28 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
29 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
30 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
31 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4 lansoprazole;esomeprazole
32 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4 esomeprazole
33 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
34 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
35 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4 pentoxifylline;pentoxifylline placebo
36 Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome Unknown status NCT02565550 Phase 4
37 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4 Tiropramide HCl 100mg;Octylonium bromide 20mg
38 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
39 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4 oral esomeprazole 20 mg twice daily;oral esomeprazole 20 mg once daily
40 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
41 Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery Unknown status NCT01797770 Phase 4 polyethylene glycol
42 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
43 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
44 Probiotic in Irritable Bowel Syndrome (IBS) Patients With Diarrhea Unknown status NCT01667627 Phase 4
45 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
46 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
47 Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4 ertapenem
48 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
49 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
50 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI

Search NIH Clinical Center for Intestinal Disease

Cochrane evidence based reviews: intestinal diseases

Genetic Tests for Intestinal Disease

Anatomical Context for Intestinal Disease

MalaCards organs/tissues related to Intestinal Disease:

39
Colon, Liver, Testes, Lung, Breast, Small Intestine, T Cells

Publications for Intestinal Disease

Articles related to Intestinal Disease:

(show top 50) (show all 370)
id Title Authors Year
1
Socioeconomic status is associated with symptom severity and sickness absence in people with infectious intestinal disease in the UK. ( 28645256 )
2017
2
Clinical outcome after enteroscopy for small bowel angioectasia bleeding: A Korean Associateion for the Study of Intestinal Disease (KASID) multiceter study. ( 27356264 )
2017
3
Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease. ( 28622393 )
2017
4
Recurrent diarrhoea in a renal transplant recipient: Early immunoproliferative small intestinal disease may be missed if not considered. ( 28205353 )
2017
5
Do surveillance intervals in patients with more than five adenomas at index colonoscopy be shorter than those in patients with three to four adenomas? A Korean Association for the Study of Intestinal Disease study. ( 27862272 )
2017
6
Hsp65-Producing Lactococcus lactis Prevents Inflammatory Intestinal Disease in Mice by IL-10- and TLR2-Dependent Pathways. ( 28194152 )
2017
7
Whole-Blood Taurine Concentrations in Cats With Intestinal Disease. ( 28626960 )
2017
8
Systematic review: exercise-induced gastrointestinal syndrome-implications for health and intestinal disease. ( 28589631 )
2017
9
Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology. ( 27632431 )
2016
10
18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model. ( 26700962 )
2016
11
Estimating the Incidence of Acute Infectious Intestinal Disease in the Community in the UK: A Retrospective Telephone Survey. ( 26807916 )
2016
12
Thromboembolism in Dogs with Protein-Losing Enteropathy with Non-Neoplastic Chronic Small Intestinal Disease. ( 27841681 )
2016
13
Sopping up IL-22 drives intestinal disease. ( 27846535 )
2016
14
Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom. ( 26641416 )
2016
15
Immunoproliferative Small Intestinal Disease Associated with Overwhelming Polymicrobial Gastrointestinal Infection with Transformation to Diffuse Large B-cell Lymphoma. ( 26903604 )
2016
16
Keratins Are Altered in Intestinal Disease-Related Stress Responses. ( 27626448 )
2016
17
Risk of Advanced Colorectal Neoplasia According to the Number of High-Risk Findings at Index Colonoscopy: A Korean Association for the Study of Intestinal Disease (KASID) Study. ( 26809871 )
2016
18
Parental Nutrition-Associated Liver Disease in Extremely Low Birth Weight Infants with Intestinal Disease. ( 25728615 )
2015
19
Cognitive Function of Patients with Crohn's Disease is Associated with Intestinal Disease Activity. ( 26398711 )
2015
20
Defective goblet cell exocytosis contributes to murine cystic fibrosis-associated intestinal disease. ( 25642775 )
2015
21
Old Friends in New Places: Exploring the Role of Extraintestinal E.A coli in Intestinal Disease and Foodborne Illness. ( 25917531 )
2015
22
Inflammatory, immunological, and intestinal disease biomarkers in Chinese Shar-Pei dogs with marked hypocobalaminemia. ( 25525135 )
2015
23
Feasibility of detecting small intestinal disease by FDG-PET/CT. ( 26070746 )
2015
24
Myocardial Function by Two-Dimensional Speckle Tracking Echocardiography and Activin A May Predict Mortality in Patients with Carcinoid Intestinal Disease. ( 26111973 )
2015
25
P578. Assessment of satisfaction with healthcare in patients with inflammatory bowel disease: An Online Korean Association for the Study of Intestinal Disease (KASID) Survey. ( 25718076 )
2015
26
Immunoproliferative small intestinal disease: a report of 6 cases. ( 26349179 )
2014
27
Contributions of NanI Sialidase to Caco-2 Cell Adherence by Clostridium perfringens Type A and C Strains Causing Human Intestinal Disease. ( 25135687 )
2014
28
Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development. ( 24447345 )
2014
29
Draft Genome Sequence of Campylobacter coli Strain IPSID-1 Isolated from a Patient with Immunoproliferative Small Intestinal Disease. ( 24625865 )
2014
30
Detection of cytomegalovirus (CMV) by real-time PCR in fecal samples for the non-invasive diagnosis of CMV intestinal disease. ( 25453330 )
2014
31
Clinical features and predictors of clinical outcomes in Korean patients with Crohn's disease: A Korean Association for the Study of Intestinal Diseases multicenter study. ( 23981141 )
2014
32
Expression of PGP 9.5 by enteric neurons in horses and donkeys with and without intestinal disease. ( 24444819 )
2014
33
Campylobacter coli cultured from the stools of a patient with immunoproliferative small intestinal disease. ( 24438451 )
2014
34
Bowel-associated dermatosis-arthritis syndrome: another cutaneous manifestation of inflammatory intestinal disease. ( 22640167 )
2013
35
The second study of infectious intestinal disease (IID2): increased rates of recurrent diarrhoea in individuals aged 65 years and above. ( 24219653 )
2013
36
Indoleamine 2,3 dioxygenase in intestinal disease. ( 23283180 )
2013
37
Osteoarticular manifestations: specific treatments and/or treating intestinal disease? ( 24030233 )
2013
38
Immunoproliferative small intestinal disease presented with ascites and edema. ( 24558774 )
2013
39
Enteric viruses in Brazilian turkey flocks: single and multiple virus infection frequency according to age and clinical signs of intestinal disease. ( 23472018 )
2013
40
Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease. ( 22527155 )
2013
41
Investigating the link between the presence of enteroaggregative Escherichia coli and infectious intestinal disease in the United Kingdom, 1993 to 1996 and 2008 to 2009. ( 24079400 )
2013
42
Monoclonal antibody testing for fecal calprotectin is superior to polyclonal testing of fecal calprotectin and lactoferrin to identify organic intestinal disease in patients with abdominal discomfort. ( 23178549 )
2013
43
Role of damage control enterostomy in management of children with peritonitis from acute intestinal disease. ( 24469480 )
2013
44
Diabetes is predominantly an intestinal disease. ( 24251223 )
2013
45
Capsule-endoscopic findings in immunoproliferative small-intestinal disease. ( 22396282 )
2012
46
Alterations in microbiota and fermentation products in equine large intestine in response to dietary variation and intestinal disease. ( 21816118 )
2012
47
Therapeutic effects of muscovite to non-steroidal anti-inflammatory drugs-induced small intestinal disease. ( 22721845 )
2012
48
Whipple's disease a89 a rare intestinal disease and its sonographic characteristics. ( 22179803 )
2012
49
Longitudinal study of infectious intestinal disease in the UK (IID2 study): incidence in the community and presenting to general practice. ( 21708822 )
2012
50
Immunoproliferative small intestinal disease associated with Campylobacter jejuni. ( 22552252 )
2012

Variations for Intestinal Disease

Copy number variations for Intestinal Disease from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 37762 1 94500000 107000000 Gain AMY1 Intestinal disease
2 37786 1 94700000 107200000 Loss AMY1 Intestinal disease
3 84156 14 23788159 23802256 Insertion TGM1 Intestinal disease

Expression for Intestinal Disease

Search GEO for disease gene expression data for Intestinal Disease.

Pathways for Intestinal Disease

Pathways related to Intestinal Disease according to GeneCards Suite gene sharing:

(show all 47)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 AREG IL10 IL17A IL1B IL6 TLR9
2
Show member pathways
13 ATG16L1 IL1B IL6 NOD2 TLR9 TNF
3
Show member pathways
12.87 IL10 IL1B IL6 TLR9 TNF
4
Show member pathways
12.79 IL1B IL6 TLR9 TNF TP53
5
Show member pathways
12.71 AREG IL1B IL6 TLR9 TNF
6
Show member pathways
12.57 IL10 IL17A IL1B IL6 NOD2 TNF
7 12.51 IL10 IL17A IL1B MPO TLR9 TNF
8
Show member pathways
12.51 IL10 IL17A IL1B IL6 MPO TNF
9
Show member pathways
12.44 IL10 IL17A IL1B IL6 TNF
10
Show member pathways
12.33 IL17A IL1B IL6 TNF
11
Show member pathways
12.27 IL1B IL6 TNF TP53
12
Show member pathways
12.19 IL1B IL6 TLR9 TNF
13 12.18 IL6 TLR9 TNF TP53
14 12.17 IL10 IL1B IL6 TNF
15 12.13 IL10 IL1B IL6 NOD2 TLR9 TNF
16
Show member pathways
12.12 IL10 IL17A IL1B IL6 TNF
17 12.09 IL1B SDC1 TNF TP53
18 12.02 IL1B IL6 TNF TP53
19 11.96 IL1B IL6 NOD2 TNF
20 11.96 IL10 IL6 MPO SDC1 TNF
21 11.95 ATG16L1 IL1B IL6 TP53
22
Show member pathways
11.92 IL17A IL1B IL6 TLR9
23 11.9 IL10 IL1B IL6 TNF
24 11.86 IL17A IL1B IL6 TNF
25 11.86 IL10 IL17A IL1B IL6 TNF TP53
26 11.8 IL10 IL17A IL1B TNF
27 11.77 IL10 IL1B IL6 TNF
28
Show member pathways
11.76 IL10 IL17A IL1B IL6 TLR9 TNF
29 11.69 IL10 IL6 TLR9 TNF
30 11.66 IL1B IL6 TNF
31
Show member pathways
11.66 IL1B IL6 TNF
32 11.65 IL10 IL1B IL6 TLR9 TNF
33 11.6 IL1B IL6 TNF
34 11.56 IL6 TNF TP53
35 11.52 IL10 IL1B IL6 TNF
36 11.51 IL6 MPO TNF
37 11.48 IL1B IL6 TNF
38 11.32 IL10 IL1B IL6 TNF
39 11.31 IL1B IL6 TNF
40 11.23 IL10 IL1B IL6 TNF
41 11.2 IL10 IL17A IL1B IL6 TNF
42 11.1 IL10 IL1B IL6 TLR9 TNF
43 11.05 CRP IL6 TNF
44 10.95 IL1B MPO TNF
45 10.88 IL1B IL6
46 10.86 AREG IL17A IL1B IL6 TNF
47 10.79 IL10 IL1B IL6 SDC1 TLR9 TNF

GO Terms for Intestinal Disease

Cellular components related to Intestinal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 CORT CRP GCG GHRL IL10 IL17A
2 external side of plasma membrane GO:0009897 9.55 IL17A IL6 SDC1 TNF TRPV1
3 extracellular space GO:0005615 9.4 AREG CORT CRP GCG GHRL IL10

Biological processes related to Intestinal Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.99 GCG IL6 NOD2 TNF
2 aging GO:0007568 9.98 EDNRB IL10 IL6 MPO
3 defense response to bacterium GO:0042742 9.98 IL10 MPO NOD2