MCID: INT069
MIFTS: 36

Intestinal Neoplasm malady

Summaries for Intestinal Neoplasm

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Intestinal neoplasms can refer to: more...

MalaCards: Intestinal Neoplasm, also known as intestinal neoplasms, is related to adenoma and familial adenomatous polyposis. An important gene associated with Intestinal Neoplasm is APC (adenomatous polyposis coli), and among its related pathways are IL-3 Signaling Pathway and Development EGFR signaling pathway. The compounds matrigel and cilomilast have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and skeleton.

Aliases & Classifications for Intestinal Neoplasm

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

intestinal neoplasm 8 10
intestinal neoplasms 45 61
neoplasm of intestinal tract 8
intestinal tumors 8
intestine growth 8


External Ids:

Disease Ontology8 DOID:4610
MeSH35 D007414
SNOMED-CT57 126769007
NCIt40 C3141

Related Diseases for Intestinal Neoplasm

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intestinal Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.0BRAF, APC, KRAS, PTGS2
2familial adenomatous polyposis29.8BRAF, APC, KRAS, PTGS2
3small intestine neoplasm10.2
4short bowel syndrome10.0
5short syndrome10.0
6pituitary adenoma10.0APC
7pituitary tumors10.0APC
8fibromatosis10.0APC
9cervical squamous cell carcinoma10.0KRAS
10juvenile polyposis syndrome10.0APC
11liver cirrhosis10.0KRAS
12testicular cancer10.0KRAS
13hepatitis c10.0KRAS
14hepatitis b10.0KRAS
15esophageal cancer10.0PTGS2
16myelodysplastic syndromes10.0KRAS
17gastric ulcer10.0PTGS2
18pancreatitis10.0KRAS
19periodontal disease10.0MMP2
20pulmonary disease, chronic obstructive10.0MMP9
21hepatitis10.0KRAS
22alzheimer's disease10.0PTGS2
23gastrointestinal system disease10.0PTGS2
24diabetes mellitus10.0MMP9
25multiple sclerosis10.0MMP9
26gallbladder cancer10.0APC, KRAS
27periodontitis10.0MMP9
28laryngeal carcinoma10.0MMP2
29kawasaki disease10.0MMP9
30encephalomyelitis10.0BMP6
31myeloid leukemia10.0BMP6
32laryngeal squamous cell carcinoma10.0MMP2
33colon adenocarcinoma10.0PTGS2, KRAS
34astrocytoma10.0MMP9, MMP2
35sarcoma10.0KRAS, BRAF
36endometriosis10.0MMP2, PTGS2
37rectum cancer10.0KRAS, APC
38hypertension10.0MMP9
39cardiofaciocutaneous syndrome10.0KRAS, BRAF
40tongue cancer10.0MMP9, MMP2
41conjunctivochalasis10.0MMP2, MMP9
42primary hyperoxaluria10.0PTGS2, MMP2
43thyroid cancer10.0BRAF, APC
44vascular disease10.0MMP2, PTGS2
45seminoma10.0KRAS, BRAF
46costello syndrome10.0BRAF, KRAS
47abdominal aortic aneurysm10.0MMP2, MMP9
48gastric adenocarcinoma10.0PTGS2, KRAS, APC
49lynch syndrome10.0BRAF, APC, KRAS
50proteinuria10.0BMP6

Graphical network of the top 20 diseases related to Intestinal Neoplasm:



Diseases related to intestinal neoplasm

Clinical Features for Intestinal Neoplasm

Drugs & Therapeutics for Intestinal Neoplasm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Intestinal Neoplasm

Drug clinical trials:

Search ClinicalTrials for Intestinal Neoplasm

Search NIH Clinical Center for Intestinal Neoplasm

Search CenterWatch for Intestinal Neoplasm

Genetic Tests for Intestinal Neoplasm

Anatomical Context for Intestinal Neoplasm

Animal Models for Intestinal Neoplasm or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Intestinal Neoplasm

Sources:
51PubMed
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Articles related to Intestinal Neoplasm:

(show all 22)
idTitleAuthorsYear
1
Liver-intestine cadherin expression is associated with intestinal differentiation and carcinogenesis in intraductal papillary mucinous neoplasm. (22286087)
2012
2
Emergence of CA125 immunoreactivity in recurrent or metastatic primary ovarian mucinous neoplasms of the intestinal type. (21836488)
2011
3
Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis. (20139757)
2010
4
Cytoplasmic and stromal expression of laminin I^ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type. (21042753)
2010
5
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (19208363)
2009
6
REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms. (19136934)
2009
7
Low-grade mucinous epithelial neoplasm (intestinal type) arising in a mature sacrococcygeal teratoma with late recurrence as pseudomyxoma peritonei. (18289636)
2008
8
Intestinal type and endocervical-like ovarian mucinous neoplasms are immunophenotypically distinct entities. (18665037)
2008
9
High expression of intestinal-type mucin (MUC2) in intraductal papillary mucinous neoplasms coexisting with extrapancreatic gastrointestinal cancers. (16552339)
2006
10
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. (17047044)
2006
11
Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utility. (16508627)
2006
12
Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. (15542584)
2005
13
Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. (15223952)
2004
14
Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. (15048136)
2004
15
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. (10204802)
1999
16
Classification of intestinal T-cell neoplasms and their differential diagnosis. (9894471)
1999
17
Effects of intestinal bacteria on the development of colonic neoplasm II. Changes in the immunological environment. (10643943)
1999
18
Effects of intestinal bacteria on the development of colonic neoplasm: an experimental study. (10443953)
1999
19
The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions. (9684289)
1998
20
Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. (1646093)
1991
21
Three cases of small-intestinal neoplasm with unusual clinical features. (13059482)
1953
22
Three cases of small intestinal neoplasm. (13083804)
1953

Genetic Variations for Intestinal Neoplasm

Expression for genes affiliated with Intestinal Neoplasm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Neoplasm

Search GEO for disease gene expression data for Intestinal Neoplasm.

Pathways for genes affiliated with Intestinal Neoplasm

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 54Reactome, 30KEGG, 53R&D Systems, 4Cell Signaling Technology
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Pathways related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MMP2
2
Hide members
10.1BRAF
39.8APC, BRAF
49.8KRAS, BRAF
5
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9.8BRAF, KRAS
69.8KRAS, BRAF
7
Hide members
9.8KRAS, BRAF
89.8MMP9, MMP2
99.8MMP9, MMP2
109.8MMP9, MMP2
119.8MMP9, MMP2
12
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9.5APC, BRAF, KRAS
139.5MMP9, MMP2, APC
14
Development Endothelin-1/EDNRA signaling
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9.5MMP9, MMP2, KRAS
159.4KRAS, APC, PTGS2
169.3KRAS, PTGS2, BRAF
179.3MMP9, MMP2, PTGS2
189.1KRAS, APC, MMP9, PTGS2
199.0MMP9, BRAF, MMP2, KRAS
20
Hide members
9.0APC, KRAS, BRAF, PTGS2
21
Hide members
8.8MMP9, BRAF, BMP6, MMP2
22
Hide members
8.7BRAF, BMP6, MMP9, PTGS2
23
Hide members
8.4PTGS2, MMP9, MMP2, BMP6, BRAF
248.3BRAF, KRAS, MMP9, MMP2, APC, PTGS2

Compounds for genes affiliated with Intestinal Neoplasm

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
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Compounds related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1matrigel4510.4BRAF
2cilomilast4510.2MMP9
3cgs-27023a4510.1MMP2, MMP9
4flavanol4510.1MMP2, MMP9
5col 34510.1MMP2, MMP9
6methyl selenol4510.1MMP2, MMP9
7panitumumab45 50 1112.1BRAF, KRAS
8prinomastat4510.1MMP2, MMP9
9trapidil4510.1MMP2, MMP9
10tranilast4510.0BMP6, MMP2
11lercanidipine45 1111.0MMP2, MMP9
12ilomastat4510.0MMP2, MMP9
13halofuginone4510.0MMP2, BMP6
14gelfoam459.9MMP2, MMP9
15o6-methylguanine459.9APC, KRAS, BRAF
16crcs459.9BRAF, APC, KRAS
17nobiletin459.8MMP9, PTGS2
18latanoprost45 1110.8MMP2, MMP9
19pge2459.7PTGS2, MMP2, MMP9
20ciglitazone45 2910.7PTGS2, MMP2, MMP9
21ns 39845 6010.7MMP2, MMP9, PTGS2
22pioglitazone45 50 29 1112.6MMP2, MMP9, PTGS2
23pdtc459.6MMP2, MMP9, PTGS2
24irinotecan45 50 1111.6KRAS, PTGS2, BRAF
25hydroxyproline45 11 2411.6BMP6, MMP9, MMP2
26ag 1478459.6MMP2, MMP9, PTGS2
27tyrosine459.5APC, KRAS, BRAF
28celecoxib45 60 29 50 11 2414.5APC, MMP2, PTGS2, MMP9
29ibuprofen45 29 50 11 2413.5PTGS2, MMP2, BMP6
30gefitinib45 50 1111.4KRAS, MMP9, MMP2, PTGS2
31curcumin459.4MMP9, APC, MMP2, PTGS2
32silymarin459.2MMP9, MMP2, PTGS2, BMP6
33aspirin45 50 29 2412.2BMP6, MMP2, APC, PTGS2
34norepinephrine45 11 2411.2MMP9, BMP6, MMP2, APC
35troglitazone45 29 60 1112.2MMP9, PTGS2, MMP2, BMP6
36rapamycin459.2BRAF, APC, BMP6, KRAS
37wortmannin459.2APC, MMP9, KRAS, BRAF, MMP2
38herbimycin a45 6010.2PTGS2, MMP2, MMP9, BMP6
39paraffin459.2BRAF, MMP9, KRAS, APC, MMP2
4012-o-tetradecanoylphorbol 13-acetate459.2MMP2, MMP9, BRAF, BMP6
41atorvastatin45 50 29 11 2413.1MMP9, BMP6, MMP2
42p002459.1BRAF, KRAS, MMP9
43sb 20358045 609.8BRAF, MMP2, PTGS2, MMP9, BMP6
44pd 98,059458.8BMP6, BRAF, MMP2, MMP9, PTGS2
45phosphatidylinositol458.7MMP2, MMP9, BMP6, APC, BRAF, KRAS
46retinoic acid45 249.6BMP6, KRAS, MMP9, APC, BRAF, MMP2
47ly294002458.5BMP6, KRAS, MMP9, MMP2, PTGS2, BRAF
48vegf458.5BMP6, MMP9, MMP2, BRAF, KRAS, PTGS2
49serine458.2MMP2, BRAF, APC, KRAS, BMP6, MMP9
50estrogen458.2BRAF, APC, BMP6, MMP2, MMP9, KRAS

GO Terms for genes affiliated with Intestinal Neoplasm

Sources:
16Gene Ontology
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Biological processes related to Intestinal Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoid stimulusGO:0513849.2PTGS2, KRAS, BMP6
2embryo implantationGO:0075669.0PTGS2, MMP9, MMP2

Products for genes affiliated with Intestinal Neoplasm

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Sources for Intestinal Neoplasm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet