MCID: INT069
MIFTS: 41

Intestinal Neoplasm malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Intestinal Neoplasm

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MedlinePlus:33 Your small intestine is part of your digestive system. it is a long tube that connects your stomach to your large intestine. intestinal cancer is rare, but eating a high-fat diet or having crohn's disease, celiac disease, or a history of colonic polyps can increase your risk. possible signs of small intestine cancer include abdominal pain weight loss for no reason blood in the stool a lump in the abdomen imaging tests that create pictures of the small intestine and the area around it can help diagnose intestinal cancer and show whether it has spread. surgery is the most common treatment. additional options include chemotherapy, radiation therapy, or a combination. nih: national cancer institute

MalaCards based summary: Intestinal Neoplasm, also known as intestinal cancer, is related to gallbladder cancer and lung cancer. An important gene associated with Intestinal Neoplasm is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways are FGFR ligand binding and activation and TGF-beta Signaling Pathways. The compounds panitumumab and halofuginone have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and testes, and related mouse phenotypes are pigmentation and renal/urinary system.

Aliases & Classifications for Intestinal Neoplasm

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Sources:
11DISEASES, 44Novoseek, 33MedlinePlus, 61UMLS
See all sources

Intestinal Neoplasm, Aliases & Descriptions:

Name: Intestinal Neoplasm 11
Intestinal Cancer 44 33 61
 
Intestinal Carcinoma 44 61
Intestinal Neoplasms 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Related Diseases for Intestinal Neoplasm

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Diseases in the Intestinal Benign Neoplasm family:

intestinal neoplasm

Diseases related to Intestinal Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer30.2KRAS, APC
2lung cancer29.6KRAS, MMP2, MMP9
3colorectal cancer29.2APC, BRAF, MMP9, MMP2, KRAS
4adenocarcinoma28.7APC, BRAF, MMP9, MMP2, BMP6, KRAS
5fibromatosis10.4APC
6stomach cancer10.3KRAS, APC
7gastric cancer, somatic10.3KRAS, APC
8large intestine cancer10.3
9rectal neoplasm10.3KRAS, APC
10cardiofaciocutaneous syndrome10.2KRAS, BRAF
11costello syndrome10.2KRAS, BRAF
12cystadenoma10.2BRAF, KRAS
13noonan syndrome10.2KRAS, BRAF
14endometrial carcinoma10.2BRAF, KRAS
15thyroid adenoma10.2APC, BRAF
16seminoma10.2KRAS, BRAF
17hypertrophic scars10.1MMP2, BMP6
18small intestine cancer, childhood10.1
19papillary thyroid carcinoma10.1BRAF, APC
20cholangiocarcinoma10.1BRAF, KRAS
21uveal melanoma10.1MMP2, BRAF
22small intestine cancer10.1
23gastric adenocarcinoma10.1KRAS, APC
24glomerulosclerosis10.1MMP2, BMP6
25lynch syndrome10.1KRAS, BRAF, APC
26familial adenomatous polyposis10.1APC, BRAF, KRAS
27breast cancer10.1APC, BMP6, KRAS
28tongue cancer10.0MMP2, MMP9
29bone cancer10.0BMP6, MMP9
30conjunctivochalasis10.0MMP9, MMP2
31retinoblastoma10.0APC, BMP6, KRAS
32abdominal aortic aneurysm10.0MMP9, MMP2
33keratitis10.0MMP2, MMP9
34bladder carcinoma in situ10.0MMP2, MMP9
35adenoma10.0KRAS, BRAF, APC
36cervical cancer10.0KRAS, MMP2, BRAF
37idiopathic pulmonary fibrosis10.0MMP9, BMP6
38aneurysm10.0MMP2, MMP9
39grade iii astrocytoma10.0MMP2, MMP9
40meckel's diverticulum9.9
41intestinal benign neoplasm9.9
42clear cell adenocarcinoma9.9
43urticaria pigmentosa9.9
44small intestine adenocarcinoma9.9
45acute porphyria9.9
46porphyria9.9
47urticaria9.9
48thyroid hurthle cell carcinoma9.9APC, BRAF
49periodontal disease9.9MMP2, MMP9
50large intestine adenocarcinoma9.9

Graphical network of the top 20 diseases related to Intestinal Neoplasm:



Diseases related to intestinal neoplasm

Symptoms for Intestinal Neoplasm

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Drugs & Therapeutics for Intestinal Neoplasm

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Drug clinical trials:

Search ClinicalTrials for Intestinal Neoplasm

Search NIH Clinical Center for Intestinal Neoplasm

Genetic Tests for Intestinal Neoplasm

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Anatomical Context for Intestinal Neoplasm

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MalaCards organs/tissues related to Intestinal Neoplasm:

32
Small intestine, Colon, Testes

Animal Models for Intestinal Neoplasm or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Neoplasm:

36 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2APC, BRAF, KRAS
2MP:00053678.5APC, BRAF, MMP9, KRAS
3MP:00053818.4KRAS, MMP9, BRAF, APC
4MP:00053888.3BRAF, MMP9, MMP2, KRAS
5MP:00107718.2APC, BRAF, MMP9, KRAS
6MP:00028738.2APC, BRAF, MMP2, KRAS
7MP:00053898.0KRAS, BMP6, MMP9, BRAF, APC
8MP:00020068.0KRAS, MMP2, MMP9, BRAF, APC
9MP:00053918.0APC, BRAF, MMP9, MMP2, KRAS
10MP:00053697.9APC, BRAF, MMP9, MMP2, KRAS
11MP:00053857.9APC, BRAF, MMP9, MMP2, KRAS
12MP:00053977.9KRAS, MMP2, MMP9, BRAF, APC
13MP:00053877.8KRAS, MMP2, MMP9, BRAF, APC
14MP:00053907.8APC, BRAF, MMP9, MMP2, BMP6
15MP:00036317.8APC, BRAF, MMP9, MMP2, KRAS
16MP:00053767.6KRAS, MMP2, MMP9, BRAF, APC
17MP:00107687.6KRAS, MMP2, MMP9, BRAF, APC
18MP:00053787.4APC, BRAF, MMP9, MMP2, BMP6, KRAS

Publications for Intestinal Neoplasm

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Articles related to Intestinal Neoplasm:

idTitleAuthorsYear
1
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (19208363)
2009
2
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. (17047044)
2006
3
Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. (1646093)
1991
4
Three cases of small-intestinal neoplasm with unusual clinical features. (13059482)
1953
5
Three cases of small intestinal neoplasm. (13083804)
1953

Variations for Intestinal Neoplasm

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Expression for genes affiliated with Intestinal Neoplasm

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Expression patterns in normal tissues for genes affiliated with Intestinal Neoplasm

Search GEO for disease gene expression data for Intestinal Neoplasm.

Pathways for genes affiliated with Intestinal Neoplasm

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Pathways related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5BRAF, KRAS
29.5BRAF, KRAS
39.5KRAS, BRAF
49.5BRAF, KRAS
59.5BRAF, KRAS
6
Show member pathways
9.5BRAF, KRAS
79.5BRAF, KRAS
8
Show member pathways
9.5KRAS, BRAF
9
Show member pathways
9.5KRAS, BRAF
10
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.5KRAS, BRAF
11
Show member pathways
9.5KRAS, BRAF
12
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway37
9.5BRAF, KRAS
13
Show member pathways
9.5BRAF, KRAS
14
Show member pathways
9.5KRAS, BRAF
15
Show member pathways
RAC1 signaling pathway37
9.5BRAF, APC
169.5BRAF, APC
179.1MMP9, BMP6
18
Show member pathways
Signal transduction PTEN pathway59
9.1KRAS, BRAF, APC
19
Show member pathways
9.1APC, BRAF, KRAS
209.0MMP9, MMP2
219.0MMP2, MMP9
22
Show member pathways
9.0MMP2, MMP9
239.0MMP2, MMP9
249.0MMP9, MMP2
259.0MMP9, MMP2
269.0MMP9, MMP2
279.0MMP2, MMP9
289.0MMP2, MMP9
299.0MMP2, MMP9
30
Show member pathways
9.0MMP2, MMP9
31
Show member pathways
9.0APC, BRAF, BMP6
328.8APC, MMP9, KRAS
338.6MMP9, MMP2, KRAS
34
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
8.6MMP9, MMP2, KRAS
35
Show member pathways
8.6BRAF, MMP9, BMP6
368.6MMP2, MMP9, APC
37
Show member pathways
8.5BRAF, MMP9, MMP2
38
Show member pathways
8.3KRAS, MMP9, BRAF, APC
398.1BRAF, MMP9, MMP2, KRAS
40
Show member pathways
Signaling Pathways in Glioblastoma37
8.1KRAS, MMP2, MMP9, BRAF
418.1APC, BRAF, MMP9, MMP2
42
Show member pathways
8.0BMP6, MMP2, MMP9, BRAF
43
Show member pathways
8.0BRAF, MMP9, MMP2, BMP6
447.6KRAS, MMP2, MMP9, BRAF, APC

Compounds for genes affiliated with Intestinal Neoplasm

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Compounds related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1211.9BRAF, KRAS
2halofuginone449.7BMP6, MMP2
3o6-methylguanine449.5KRAS, BRAF, APC
4crcs449.5APC, KRAS, BRAF
5flavanol449.4MMP9, MMP2
6cgs-27023a449.4MMP2, MMP9
7col 3449.4MMP9, MMP2
8methyl selenol449.4MMP9, MMP2
9prinomastat449.4MMP2, MMP9
10trapidil449.3MMP2, MMP9
11ilomastat449.3MMP2, MMP9
12lercanidipine44 1210.3MMP2, MMP9
13gelfoam449.2MMP2, MMP9
14cilomilast449.0MMP2, MMP9
15p002449.0MMP9, BRAF, KRAS
16rapamycin449.0BMP6, BRAF, APC, KRAS
17gefitinib44 50 1211.0MMP9, MMP2, KRAS
18tranilast448.9MMP9, MMP2, BMP6
19celecoxib44 60 29 50 25 1213.9APC, MMP9, MMP2
20latanoprost44 129.9MMP9, MMP2
21silymarin448.9BMP6, MMP2, MMP9
22hydroxyproline44 25 1210.9MMP9, MMP2, BMP6
23procollagen448.9BMP6, MMP9, MMP2
24atorvastatin44 50 29 25 1212.8BMP6, MMP9, MMP2
25troglitazone44 29 60 1211.7BMP6, MMP9, MMP2
26imatinib44 50 1210.7BRAF, KRAS, BMP6
27tgf beta1448.7MMP9, MMP2, BMP6
28herbimycin a44 609.7MMP9, MMP2, BMP6
29oligonucleotide448.6BRAF, APC, KRAS, BMP6
30progesterone44 29 60 25 1212.6BMP6, MMP2, BRAF, APC
31hyaluronic acid44 259.6MMP9, MMP2, BMP6
32curcumin448.6MMP2, MMP9, APC
33epinephrine44 25 1210.5APC, MMP2, BMP6, MMP9
34norepinephrine44 25 1210.5MMP2, MMP9, BMP6, APC
35pge2448.4BMP6, MMP9, APC, MMP2
36matrigel448.4MMP2, BMP6, MMP9, BRAF
3712-o-tetradecanoylphorbol 13-acetate448.4MMP2, BRAF, MMP9, BMP6
38sb 20358044 609.4BRAF, MMP9, MMP2, BMP6
39pd 98,059448.4BMP6, BRAF, MMP2, MMP9
40cycloheximide448.4APC, BMP6, MMP2, MMP9
41aspartate448.3MMP2, BMP6, BRAF, MMP9
42wortmannin448.1APC, KRAS, MMP9, MMP2, BRAF
43paraffin448.1APC, BRAF, MMP9, MMP2, KRAS
44ly294002448.0MMP2, MMP9, BRAF, BMP6, KRAS
45vegf448.0BMP6, KRAS, MMP2, MMP9, BRAF
46phosphatidylinositol447.6BRAF, APC, MMP9, KRAS, MMP2, BMP6
47estrogen447.6KRAS, BMP6, MMP2, BRAF, APC, MMP9
48retinoic acid44 258.6KRAS, APC, BRAF, MMP9, MMP2, BMP6
49serine447.6APC, BRAF, MMP2, BMP6, KRAS, MMP9
50tyrosine447.6MMP9, BRAF, MMP2, BMP6, APC, KRAS

GO Terms for genes affiliated with Intestinal Neoplasm

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Biological processes related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:0001869.7KRAS, BRAF
2response to glucocorticoidGO:0513849.6KRAS, BMP6
3kidney developmentGO:0018229.4BMP6, APC
4leukocyte migrationGO:0509009.2KRAS, MMP9
5embryo implantationGO:0075669.2MMP2, MMP9
6collagen catabolic processGO:0305749.0MMP9, MMP2
7extracellular matrix disassemblyGO:0226178.7MMP2, MMP9

Molecular functions related to Intestinal Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.0MMP2, MMP9

Products for genes affiliated with Intestinal Neoplasm

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Sources for Intestinal Neoplasm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet