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MCID: INT069

Intestinal Neoplasm malady
18 drugs, 11 genes, 1016 related diseases, 8 phenotypes, 2 articles, clinical trials.

Summaries for Intestinal Neoplasm

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44Wikipedia, 22MalaCards
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Wikipedia: Intestinal neoplasms can refer to:44 more...

MalaCards: Intestinal Neoplasm, also known as intestinal neoplasms, is related to tongue cancer and thyroid cancer. An important gene associated with Intestinal Neoplasm is APC (adenomatous polyposis coli), and among its related pathways are Colorectal cancer and Pathway_PA165959425. The drugs prednisone and prednisolone tebutate and the compounds pge2 and panitumumab have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and renal/urinary system.

Aliases & Descriptions for Intestinal Neoplasm

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH
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Aliases & Descriptions:

intestinal neoplasm 6 8
intestinal neoplasms 32 43
neoplasm of intestinal tract 6
intestinal tumors 6
intestine growth 6
neoplasms 43

External Ids:

NCIt27 C3141
SNOMED-CT40 126769007

Related Diseases for Intestinal Neoplasm

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13GeneCards, 14GeneDecks
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Diseases related to intestinal neoplasm by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1013)
idRelated DiseaseScoreTop Affiliating Genes
1tongue cancer30.7MMP2, MMP9
2thyroid cancer30.1BRAF, APC
3thyroiditis29.7BRAF, BMP6, MMP2, MMP9, APC, PTGS2
4ovarian mucinous neoplasm28.2BRAF, MMP9, APC, KRAS
5breast cancer27.9MMP2, MMP9, PTGS2
6lynch syndrome27.7BRAF, APC, KRAS
7basal cell carcinoma27.1BRAF, BMP6, MMP2, APC, PTGS2
8adenocarcinoma27.0BRAF, BMP6, MMP2, MMP9, APC, PTGS2
9thrombosis26.7MMP2, MMP9, APC, PTGS2
10cervicitis26.6BRAF, BMP6, MMP2, MMP9, APC, PTGS2
11gastrointestinal stromal tumor26.5BRAF, MMP9, PTGS2
12seminoma26.4BRAF, APC, KRAS
13adenoiditis26.3BMP6, MMP2, MMP9, PTGS2
14esophageal cancer26.3BRAF, BMP6, MMP2, MMP9, APC, PTGS2
15meningioma26.0MMP2, MMP9, APC, PTGS2, KRAS
16testicular cancer26.0BMP6, MMP2, MMP9, KRAS
17ovarian cancer26.0BRAF, BMP6, MMP2, MMP9, APC, PTGS2
18myelodysplastic syndrome25.9BMP6, MMP2, MMP9, KRAS
19pancreatic ductal carcinoma25.8MMP9, APC, PTGS2, KRAS
20adenoma25.8BRAF, BMP6, MMP2, MMP9, APC, PTGS2
21sarcoma25.8BRAF, BMP6, MMP2, MMP9, APC, PTGS2
22giant cell tumor25.8BMP6, MMP9, PTGS2
23laryngitis25.7BMP6, MMP2, MMP9, PTGS2
24pancreatic cancer25.7BRAF, BMP6, MMP2, MMP9, APC, PTGS2
25wilms tumor25.6BMP6, MMP9, PTGS2, KRAS
26leiomyoma25.6BMP6, MMP2, MMP9, PTGS2, KRAS
27adenoid cystic carcinoma25.6BMP6, MMP2, MMP9, PTGS2
28pancreatic ductal adenocarcinoma25.4BRAF, BMP6, MMP9, APC, PTGS2, KRAS
29familial adenomatous polyposis25.3BRAF, BMP6, APC, PTGS2, KRAS
30synovial sarcoma25.3MMP2, APC, PTGS2
31pituitary tumor25.2MMP2, MMP9, APC, PTGS2
32attenuated familial adenomatous polyposis25.1APC, PTGS2
33retinoblastoma25.1BMP6, MMP2, MMP9, APC, KRAS
34inflammatory bowel disease25.0BRAF, BMP6, MMP2, MMP9, APC, PTGS2
35melanoma24.9BRAF, BMP6, MMP2, MMP9, APC, PTGS2
36urinary bladder cancer24.8MMP2, MMP9, PTGS2, KRAS
37chronic myeloid leukemia24.7BRAF, BMP6, PTGS2, KRAS
38plasma cell leukemia24.6BRAF, KRAS
39malignant mesothelioma24.6BMP6, MMP2, MMP9, APC, KRAS
40serous cystadenoma24.6BRAF, KRAS
41familial pancreatic cancer24.5BRAF, KRAS
42familial colorectal cancer24.5BRAF, APC, KRAS
43cervical cancer24.5BRAF, BMP6, MMP2, MMP9, APC, PTGS2
44renal cell carcinoma24.5BRAF, BMP6, MMP2, MMP9, APC, PTGS2
45breast carcinoma24.5BRAF, BMP6, MMP2, MMP9, APC, PTGS2
46squamous cell carcinoma24.4BRAF, BMP6, MMP2, MMP9, APC, PTGS2
47adenomatous polyposis coli24.4BMP6, APC, PTGS2
48t-cell leukemia24.4BRAF, BMP6, MMP9, PTGS2, KRAS
49choroiditis24.3BRAF, BMP6, MMP2, MMP9, PTGS2
50laryngeal carcinoma24.3MMP2, MMP9, PTGS2

Graphical network of the top 20 diseases related to intestinal neoplasm:



Graphical network of diseases related to intestinal neoplasm

Clinical Features for Intestinal Neoplasm

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Drugs & Therapeutics for Intestinal Neoplasm

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for intestinal neoplasm

Drug clinical trials:

Search ClinicalTrials for intestinal neoplasm

Search NIH Clinical Center for intestinal neoplasm

Search CenterWatch for intestinal neoplasm

Inferred drug relations via UMLS/NDF-RT:

43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

Genetic Tests for Intestinal Neoplasm

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Anatomical Context for Intestinal Neoplasm

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Phenotypes for genes affiliated with Intestinal Neoplasm

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25MGI
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MGI Mouse Phenotypes related to intestinal neoplasm:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1digestive/alimentary phenotypeMP:00053818.1BRAF, MMP9, APC, PTGS2, KRAS
2renal/urinary system phenotypeMP:00053677.8KRAS, PTGS2, APC, MMP9, BRAF
3tumorigenesisMP:00020067.4KRAS, PTGS2, APC, MMP9, MMP2, BRAF
4vision/eye phenotypeMP:00053917.4KRAS, PTGS2, APC, MMP9, MMP2, BRAF
5skeleton phenotypeMP:00053907.3PTGS2, APC, MMP9, MMP2, BMP6, BRAF
6muscle phenotypeMP:00053697.1BRAF, KRAS, PTGS2, APC, MMP9, MMP2
7cardiovascular system phenotypeMP:00053856.9KRAS, PTGS2, APC, MMP9, MMP2, MYOF
8growth/size phenotypeMP:00053786.5KRAS, PTGS2, APC, MMP9, MMP2, BMP6

Publications for genes affiliated with Intestinal Neoplasm

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35PubMed
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Articles related to intestinal neoplasm:

idTitleAuthorsYearAffiliating Genes
1TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (19208363)Trobridge P.... Grady W.M.2009BRAF, KRAS
2Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. (17047044)MuA+oz N.M.... Grady W.M.2006MMP2, APC, MMP9

Expression for genes affiliated with Intestinal Neoplasm

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Intestinal Neoplasm

Pathways for genes affiliated with Intestinal Neoplasm

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20KEGG, 34PharmGKB, 38Reactome, 3Cell Signaling Technology, 36QIAGEN
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Pathways related to intestinal neoplasm according to GeneDecks:

(show all 11)
idPathwayScoreTop Affiliating Genes
1Colorectal cancer2010.1BRAF
2Pathway_PA165959425349.5KRAS, BRAF
3Pathway_PA165980050349.5BRAF, KRAS
4Endometrial cancer209.4BRAF, APC, KRAS
5Pathways in cancer208.8MMP2, MMP9, KRAS
6Activation of Matrix Metalloproteinases388.7MMP2, MMP9
7Angiogenesis38.6MMP2, MMP9, PTGS2
8Glioma Invasiveness368.5BMP6, MMP2, MMP9
9Bladder cancer208.3BRAF, MMP2, MMP9, KRAS
10Colorectal Cancer Metastasis368.0PTGS2, APC, MMP9, MMP2, BRAF
11Pancreatic Adenocarcinoma367.8PTGS2, MMP9, MMP2, BMP6, BRAF

Compounds for genes affiliated with Intestinal Neoplasm

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32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
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Compounds related to intestinal neoplasm according to GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge232 10.6APC
2panitumumab32 34 9 9 12.8BRAF, KRAS
3estrogen32 9.8MMP2, APC
4rapamycin32 42 10.6BRAF, KRAS
5o6-methylguanine32 9.6KRAS, APC, BRAF
6halofuginone32 9.6MMP2, BMP6
7crcs32 9.6BRAF, APC, KRAS
8flavanol32 9.4MMP9, MMP2
9cgs-27023a32 9.4MMP9, MMP2
10col 332 9.4MMP2, MMP9
11methyl selenol32 9.4MMP2, MMP9
12prinomastat32 9.4MMP2, MMP9
13trapidil32 9.3MMP2, MMP9
14nobiletin32 9.3PTGS2, MMP9
15lercanidipine32 9 9 11.3MMP9, MMP2
16irinotecan32 34 9 9 12.3BRAF, PTGS2, KRAS
17ilomastat32 9.3MMP9, MMP2
18gelfoam32 9.1MMP9, MMP2
19latanoprost32 9 9 11.1MMP9, MMP2
20retinoic acid32 42 18 11.1APC, MMP9, BMP6, BRAF
21tranilast32 9.1BMP6, MMP2, MMP9
22ibuprofen32 9 18 9 12.1PTGS2, MMP2, BMP6
23hydroxyproline32 18 10.0MMP9, MMP2, BMP6
24cilomilast32 8.9MMP2, MMP9
25ciglitazone32 8.9MMP2, MMP9, PTGS2
26procollagen32 8.9MMP9, MMP2, BMP6
27p00232 8.9BRAF, MMP9, KRAS
28aspirin32 34 18 10.8BMP6, MMP2, APC, PTGS2
29pioglitazone32 9 9 10.8PTGS2, MMP9, MMP2
30pdtc32 8.8PTGS2, MMP9, MMP2
31ag 147832 8.7PTGS2, MMP9, MMP2
32epinephrine32 9 18 9 11.7APC, MMP9, MMP2, BMP6
33celecoxib32 42 34 9 18 9 13.7PTGS2, APC, MMP9, MMP2
34curcumin32 8.6PTGS2, APC, MMP9, MMP2
35silymarin32 8.5PTGS2, MMP9, MMP2, BMP6
36troglitazone32 42 9 9 11.5PTGS2, MMP9, MMP2, BMP6
37norepinephrine32 9 18 9 11.5APC, MMP9, MMP2, BMP6
38matrigel32 8.5BRAF, BMP6, MMP2, MMP9
39herbimycin a32 42 9.5PTGS2, MMP9, MMP2, BMP6
4012-o-tetradecanoylphorbol 13-acetate32 8.5MMP9, MMP2, BMP6, BRAF
41gefitinib32 34 9 9 11.4KRAS, PTGS2, MMP9, MMP2
42atorvastatin32 34 9 18 9 12.3MMP9, MMP2, BMP6
43wortmannin32 42 9.2BRAF, MMP2, MMP9, APC, KRAS
44paraffin32 8.2BRAF, MMP2, MMP9, APC, KRAS
45cycloheximide32 8.2PTGS2, APC, MMP9, MMP2, BMP6
46sb 20358032 42 9.1PTGS2, MMP9, MMP2, BMP6, BRAF
47pd 98,05932 8.1PTGS2, MMP9, MMP2, BMP6, BRAF
48phosphatidylinositol32 7.8KRAS, APC, MMP9, MMP2, BMP6, BRAF
49ly29400232 7.6BRAF, BMP6, MMP2, MMP9, PTGS2, KRAS
50vegf32 7.5BRAF, BMP6, MMP2, MMP9, PTGS2, KRAS

GO Terms for genes affiliated with Intestinal Neoplasm

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12Gene Ontology
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Biological processes related to intestinal neoplasm according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:0305749.0MMP2, MMP9
2positive regulation of synaptic plasticityGO:0319159.0MMP9, PTGS2

Sources for Intestinal Neoplasm

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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