MCID: INT069
MIFTS: 35

Intestinal Neoplasm malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Intestinal Neoplasm

About this section


MedlinePlus:32 Your small intestine is part of your digestive system. it is a long tube that connects your stomach to your large intestine. intestinal cancer is rare, but eating a high-fat diet or having crohn's disease, celiac disease, or a history of colonic polyps can increase your risk. possible signs of small intestine cancer include abdominal pain weight loss for no reason blood in the stool a lump in the abdomen imaging tests that create pictures of the small intestine and the area around it can help diagnose intestinal cancer and show whether it has spread. surgery is the most common treatment. additional options include chemotherapy, radiation therapy, or a combination. nih: national cancer institute

MalaCards based summary: Intestinal Neoplasm, also known as intestinal cancer, is related to gallbladder cancer and lung cancer. An important gene associated with Intestinal Neoplasm is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways are FGFR ligand binding and activation and TGF-beta Signaling Pathways. The compounds panitumumab and halofuginone have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and testes, and related mouse phenotypes are pigmentation and renal/urinary system.

Aliases & Classifications for Intestinal Neoplasm

About this section
Sources:
11DISEASES, 43Novoseek, 32MedlinePlus, 60UMLS
See all sources

Intestinal Neoplasm, Aliases & Descriptions:

Name: Intestinal Neoplasm 11
Intestinal Cancer 43 32 60
Intestinal Carcinoma 43
 
Intestinal Neoplasms 60
Carcinoma Intestinal 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Related Diseases for Intestinal Neoplasm

About this section

Diseases in the Intestinal Neoplasm family:

Intestinal Benign Neoplasm

Diseases related to Intestinal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer30.3APC, KRAS
2lung cancer29.6KRAS, MMP9, MMP2
3adenocarcinoma28.7MMP2, APC, MMP9, BRAF, BMP6, KRAS
4fibromatosis10.4APC
5large intestine cancer10.3
6gastric cancer, somatic10.3APC, KRAS
7rectal neoplasm10.2KRAS, APC
8cardiofaciocutaneous syndrome10.2KRAS, BRAF
9costello syndrome10.2KRAS, BRAF
10cystadenoma10.2BRAF, KRAS
11noonan syndrome 110.2BRAF, KRAS
12small intestine cancer, childhood10.2
13endometrial cancer10.2BRAF, KRAS
14thyroid adenoma10.2BRAF, APC
15seminoma10.1KRAS, BRAF
16hypertrophic scars10.1BMP6, MMP2
17cholangiocarcinoma10.1BRAF, KRAS
18small intestine cancer10.1
19thyroid carcinoma, papillary10.1APC, BRAF
20uveal melanoma10.1MMP2, BRAF
21gastric adenocarcinoma10.1KRAS, APC
22glomerulosclerosis10.1MMP2, BMP6
23lynch syndrome10.1APC, KRAS, BRAF
24adenomatous polyposis coli10.0KRAS, BRAF, APC
25breast cancer10.0APC, BMP6, KRAS
26tongue cancer10.0MMP9, MMP2
27bone cancer10.0BMP6, MMP9
28conjunctivochalasis10.0MMP9, MMP2
29retinoblastoma10.0KRAS, APC, BMP6
30abdominal aortic aneurysm10.0MMP9, MMP2
31keratitis10.0MMP2, MMP9
32bladder cancer, somatic10.0MMP2, MMP9
33adenoma10.0BRAF, APC, KRAS
34cervical cancer, somatic10.0MMP2, KRAS, BRAF
35pulmonary fibrosis, idiopathic10.0MMP9, BMP6
36aneurysm10.0MMP2, MMP9
37grade iii astrocytoma10.0MMP9, MMP2
38werner syndrome9.9
39meckel's diverticulum9.9
40intestinal benign neoplasm9.9
41chylous ascites9.9
42clear cell adenocarcinoma9.9
43urticaria pigmentosa9.9
44small intestine adenocarcinoma9.9
45acute porphyria9.9
46porphyria9.9
47urticaria9.9
48peutz-jeghers syndrome9.9
49large intestine adenocarcinoma9.9
50small intestine carcinoid neuroendocrine tumor9.9

Graphical network of the top 20 diseases related to Intestinal Neoplasm:



Diseases related to intestinal neoplasm

Symptoms for Intestinal Neoplasm

About this section

Drugs & Therapeutics for Intestinal Neoplasm

About this section

Drug clinical trials:

Search ClinicalTrials for Intestinal Neoplasm

Search NIH Clinical Center for Intestinal Neoplasm

Genetic Tests for Intestinal Neoplasm

About this section

Anatomical Context for Intestinal Neoplasm

About this section

MalaCards organs/tissues related to Intestinal Neoplasm:

31
Small intestine, Colon, Testes

Animal Models for Intestinal Neoplasm or affiliated genes

About this section

MGI Mouse Phenotypes related to Intestinal Neoplasm:

35 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2APC, BRAF, KRAS
2MP:00053678.5APC, BRAF, MMP9, KRAS
3MP:00053818.4KRAS, MMP9, BRAF, APC
4MP:00053888.3BRAF, MMP9, MMP2, KRAS
5MP:00107718.2APC, BRAF, MMP9, KRAS
6MP:00028738.2APC, BRAF, MMP2, KRAS
7MP:00053898.0KRAS, BMP6, MMP9, BRAF, APC
8MP:00020068.0KRAS, MMP2, MMP9, BRAF, APC
9MP:00053918.0APC, BRAF, MMP9, MMP2, KRAS
10MP:00053697.9APC, BRAF, MMP9, MMP2, KRAS
11MP:00053857.9APC, BRAF, MMP9, MMP2, KRAS
12MP:00053977.9KRAS, MMP2, MMP9, BRAF, APC
13MP:00053877.8KRAS, MMP2, MMP9, BRAF, APC
14MP:00053907.8APC, BRAF, MMP9, MMP2, BMP6
15MP:00036317.8APC, BRAF, MMP9, MMP2, KRAS
16MP:00053767.6KRAS, MMP2, MMP9, BRAF, APC
17MP:00107687.6KRAS, MMP2, MMP9, BRAF, APC
18MP:00053787.4APC, BRAF, MMP9, MMP2, BMP6, KRAS

Publications for Intestinal Neoplasm

About this section

Articles related to Intestinal Neoplasm:

idTitleAuthorsYear
1
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (19208363)
2009
2
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. (17047044)
2006
3
Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. (1646093)
1991
4
Three cases of small-intestinal neoplasm with unusual clinical features. (13059482)
1953
5
Three cases of small intestinal neoplasm. (13083804)
1953

Variations for Intestinal Neoplasm

About this section

Expression for genes affiliated with Intestinal Neoplasm

About this section
Search GEO for disease gene expression data for Intestinal Neoplasm.

Pathways for genes affiliated with Intestinal Neoplasm

About this section

Pathways related to Intestinal Neoplasm according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5BRAF, KRAS
29.5BRAF, KRAS
39.5KRAS, BRAF
49.5BRAF, KRAS
59.5BRAF, KRAS
6
Show member pathways
9.5BRAF, KRAS
79.5BRAF, KRAS
8
Show member pathways
9.5KRAS, BRAF
9
Show member pathways
9.5KRAS, BRAF
10
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.5KRAS, BRAF
11
Show member pathways
9.5KRAS, BRAF
12
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
9.5BRAF, KRAS
13
Show member pathways
9.5BRAF, KRAS
14
Show member pathways
9.5KRAS, BRAF
15
Show member pathways
RAC1 signaling pathway36
9.5BRAF, APC
169.5BRAF, APC
179.1MMP9, BMP6
18
Show member pathways
Signal transduction PTEN pathway58
9.1KRAS, BRAF, APC
19
Show member pathways
9.1APC, BRAF, KRAS
209.0MMP9, MMP2
219.0MMP2, MMP9
22
Show member pathways
Metalloproteases in connective tissue degradation
9.0MMP2, MMP9
239.0MMP2, MMP9
249.0MMP9, MMP2
259.0MMP9, MMP2
269.0MMP9, MMP2
279.0MMP2, MMP9
289.0MMP2, MMP9
299.0MMP2, MMP9
30
Show member pathways
9.0MMP2, MMP9
31
Show member pathways
9.0APC, BRAF, BMP6
328.8APC, MMP9, KRAS
338.6MMP9, MMP2, KRAS
34
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.6MMP9, MMP2, KRAS
35
Show member pathways
8.6BRAF, MMP9, BMP6
368.6MMP2, MMP9, APC
37
Show member pathways
8.5BRAF, MMP9, MMP2
38
Show member pathways
8.3KRAS, MMP9, BRAF, APC
398.1BRAF, MMP9, MMP2, KRAS
40
Show member pathways
Signaling Pathways in Glioblastoma36
8.1KRAS, MMP2, MMP9, BRAF
418.1APC, BRAF, MMP9, MMP2
42
Show member pathways
8.0BMP6, MMP2, MMP9, BRAF
43
Show member pathways
8.0BRAF, MMP9, MMP2, BMP6
447.6KRAS, MMP2, MMP9, BRAF, APC

Compounds for genes affiliated with Intestinal Neoplasm

About this section

Compounds related to Intestinal Neoplasm according to GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1panitumumab43 49 1211.9BRAF, KRAS
2halofuginone439.7BMP6, MMP2
3o6-methylguanine439.5KRAS, BRAF, APC
4crcs439.5APC, KRAS, BRAF
5flavanol439.4MMP9, MMP2
6cgs-27023a439.4MMP2, MMP9
7col 3439.4MMP9, MMP2
8methyl selenol439.4MMP9, MMP2
9prinomastat439.4MMP2, MMP9
10trapidil439.3MMP2, MMP9
11ilomastat439.3MMP2, MMP9
12lercanidipine43 1210.3MMP2, MMP9
13gelfoam439.2MMP2, MMP9
14cilomilast439.0MMP2, MMP9
15p002439.0MMP9, BRAF, KRAS
16rapamycin439.0BMP6, BRAF, APC, KRAS
17gefitinib43 49 1211.0MMP9, MMP2, KRAS
18tranilast438.9MMP9, MMP2, BMP6
19celecoxib43 59 28 49 24 1213.9APC, MMP9, MMP2
20latanoprost43 129.9MMP9, MMP2
21silymarin438.9BMP6, MMP2, MMP9
22hydroxyproline43 24 1210.9MMP9, MMP2, BMP6
23procollagen438.9BMP6, MMP9, MMP2
24atorvastatin43 49 28 24 1212.8BMP6, MMP9, MMP2
25troglitazone43 28 59 1211.7BMP6, MMP9, MMP2
26imatinib43 49 1210.7BRAF, KRAS, BMP6
27tgf beta1438.7MMP9, MMP2, BMP6
28herbimycin a43 599.7MMP9, MMP2, BMP6
29oligonucleotide438.6BRAF, APC, KRAS, BMP6
30progesterone43 28 59 24 1212.6BMP6, MMP2, BRAF, APC
31hyaluronic acid43 249.6MMP9, MMP2, BMP6
32curcumin438.6MMP2, MMP9, APC
33epinephrine43 24 1210.5APC, MMP2, BMP6, MMP9
34norepinephrine43 24 1210.5MMP2, MMP9, BMP6, APC
35pge2438.4BMP6, MMP9, APC, MMP2
36matrigel438.4MMP2, BMP6, MMP9, BRAF
3712-o-tetradecanoylphorbol 13-acetate438.4MMP2, BRAF, MMP9, BMP6
38sb 20358043 599.4BRAF, MMP9, MMP2, BMP6
39pd 98,059438.4BMP6, BRAF, MMP2, MMP9
40cycloheximide438.4APC, BMP6, MMP2, MMP9
41aspartate438.3MMP2, BMP6, BRAF, MMP9
42wortmannin438.1APC, KRAS, MMP9, MMP2, BRAF
43paraffin438.1APC, BRAF, MMP9, MMP2, KRAS
44ly294002438.0MMP2, MMP9, BRAF, BMP6, KRAS
45vegf438.0BMP6, KRAS, MMP2, MMP9, BRAF
46phosphatidylinositol437.6BRAF, APC, MMP9, KRAS, MMP2, BMP6
47estrogen437.6KRAS, BMP6, MMP2, BRAF, APC, MMP9
48retinoic acid43 248.6KRAS, APC, BRAF, MMP9, MMP2, BMP6
49serine437.6APC, BRAF, MMP2, BMP6, KRAS, MMP9
50tyrosine437.6MMP9, BRAF, MMP2, BMP6, APC, KRAS

GO Terms for genes affiliated with Intestinal Neoplasm

About this section

Biological processes related to Intestinal Neoplasm according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:00001869.7KRAS, BRAF
2response to glucocorticoidGO:00513849.6KRAS, BMP6
3kidney developmentGO:00018229.4BMP6, APC
4leukocyte migrationGO:00509009.2KRAS, MMP9
5embryo implantationGO:00075669.2MMP2, MMP9
6collagen catabolic processGO:00305749.0MMP9, MMP2
7extracellular matrix disassemblyGO:00226178.7MMP2, MMP9

Molecular functions related to Intestinal Neoplasm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.0MMP2, MMP9

Products for genes affiliated with Intestinal Neoplasm

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Intestinal Neoplasm

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet