MCID: INT069
MIFTS: 45

Intestinal Neoplasm malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Intestinal Neoplasm

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33MedlinePlus, 32MalaCards
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MedlinePlus:33 Your small intestine is part of your digestive system. it is a long tube that connects your stomach to your large intestine. intestinal cancer is rare, but eating a high-fat diet or having crohn's disease, celiac disease, or a history of colonic polyps can increase your risk. possible signs of small intestine cancer include abdominal pain weight loss for no reason blood in the stool a lump in the abdomen imaging tests that create pictures of the small intestine and the area around it can help diagnose intestinal cancer and show whether it has spread. surgery is the most common treatment. additional options include chemotherapy, radiation therapy, or a combination. nih: national cancer institute

MalaCards: Intestinal Neoplasm, also known as intestinal cancer, is related to colon cancer and colon adenocarcinoma. An important gene associated with Intestinal Neoplasm is APC (adenomatous polyposis coli), and among its related pathways are IL-3 Signaling Pathway and Development EGFR signaling pathway. The compounds matrigel and cilomilast have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and testes, and related mouse phenotypes are vision/eye and skeleton.

Aliases & Classifications for Intestinal Neoplasm

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intestinal neoplasm 8 10
intestinal cancer 44 33
neoplasm of intestinal tract 8
intestinal carcinoma 44
intestinal neoplasms 60
intestinal tumors 8
intestine growth 8


External Ids:

Disease Ontology8 DOID:4610
MeSH34 D007414
SNOMED-CT56 126769007
NCIt39 C3141

Related Diseases for Intestinal Neoplasm

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17GeneCards, 18GeneDecks
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Diseases related to Intestinal Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1colon cancer29.9BRAF, APC, BMP6, MMP2, MMP9, KRAS
2colon adenocarcinoma29.8PTGS2, KRAS
3gallbladder cancer29.8APC, KRAS
4pancreatitis29.8KRAS
5lung cancer29.7MMP2, MMP9, KRAS, PTGS2
6familial adenomatous polyposis29.7BRAF, APC, KRAS, PTGS2
7adenocarcinoma29.7BRAF, APC, BMP6, MMP2, MMP9, KRAS
8colorectal cancer29.7BRAF, APC, BMP6, MMP2, MMP9, KRAS
9small intestine cancer10.1
10large cell carcinoma10.1
11small intestine cancer, childhood10.1
12short bowel syndrome10.0
13inflammatory bowel disease10.0
14intestinal disease10.0
15pituitary adenoma10.0APC
16pituitary tumors10.0APC
17fibromatosis10.0APC
18cervical squamous cell carcinoma10.0KRAS
19liver cirrhosis10.0KRAS
20juvenile polyposis syndrome10.0APC
21testicular cancer10.0KRAS
22hepatitis c10.0KRAS
23hepatitis b10.0KRAS
24esophageal cancer10.0PTGS2
25myelodysplastic syndromes10.0KRAS
26gastric ulcer10.0PTGS2
27periodontal disease10.0MMP2
28pulmonary disease, chronic obstructive10.0MMP9
29hepatitis10.0KRAS
30alzheimer's disease10.0PTGS2
31gastrointestinal system disease10.0PTGS2
32diabetes mellitus10.0MMP9
33multiple sclerosis10.0MMP9
34periodontitis10.0MMP9
35laryngeal benign neoplasm10.0MMP2
36kawasaki disease10.0MMP9
37encephalomyelitis10.0BMP6
38laryngeal squamous cell carcinoma10.0MMP2
39myeloid leukemia10.0BMP6
40thyroid cancer10.0BRAF, APC
41astrocytoma10.0MMP9, MMP2
42sarcoma10.0KRAS, BRAF
43rectal neoplasm10.0KRAS, APC
44endometriosis10.0MMP2, PTGS2
45hypertension10.0MMP9
46cardiofaciocutaneous syndrome10.0KRAS, BRAF
47tongue cancer10.0MMP9, MMP2
48conjunctivochalasis10.0MMP2, MMP9
49primary hyperoxaluria10.0PTGS2, MMP2
50vascular disease10.0MMP2, PTGS2

Graphical network of the top 20 diseases related to Intestinal Neoplasm:



Diseases related to intestinal neoplasm

Clinical Features for Intestinal Neoplasm

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Drugs & Therapeutics for Intestinal Neoplasm

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intestinal Neoplasm

Drug clinical trials:

Search ClinicalTrials for Intestinal Neoplasm

Search NIH Clinical Center for Intestinal Neoplasm

Search CenterWatch for Intestinal Neoplasm

Genetic Tests for Intestinal Neoplasm

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Anatomical Context for Intestinal Neoplasm

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32MalaCards
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MalaCards organs/tissues related to Intestinal Neoplasm:

32
Small intestine, Colon, Testes, Liver, T cells, B cells

Animal Models for Intestinal Neoplasm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intestinal Neoplasm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.3APC
2MP:000539010.3APC
3MP:000536710.1APC
4MP:00020069.6MMP9, BRAF, KRAS
5MP:00053699.0MMP2, APC, MYOF, BRAF, MMP9
6MP:00053888.7PTGS2, KRAS, MMP9, MMP2
7MP:00053818.7APC, KRAS, BRAF, PTGS2, MMP9
8MP:00053898.2PTGS2, KRAS, MMP9, BMP6, APC, BRAF
9MP:00053858.1KRAS, MMP9, MMP2, MYOF, APC, BRAF
10MP:00053787.6BRAF, APC, BMP6, MYOF, MMP2, MMP9

Publications for Intestinal Neoplasm

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50PubMed
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Articles related to Intestinal Neoplasm:

(show all 21)
idTitleAuthorsYear
1
Liver-intestine cadherin expression is associated with intestinal differentiation and carcinogenesis in intraductal papillary mucinous neoplasm. (22286087)
2012
2
Emergence of CA125 immunoreactivity in recurrent or metastatic primary ovarian mucinous neoplasms of the intestinal type. (21836488)
2011
3
Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis. (20139757)
2010
4
Cytoplasmic and stromal expression of laminin I^ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type. (21042753)
2010
5
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (19208363)
2009
6
REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms. (19136934)
2009
7
Low-grade mucinous epithelial neoplasm (intestinal type) arising in a mature sacrococcygeal teratoma with late recurrence as pseudomyxoma peritonei. (18289636)
2008
8
Intestinal type and endocervical-like ovarian mucinous neoplasms are immunophenotypically distinct entities. (18665037)
2008
9
High expression of intestinal-type mucin (MUC2) in intraductal papillary mucinous neoplasms coexisting with extrapancreatic gastrointestinal cancers. (16552339)
2006
10
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. (17047044)
2006
11
Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utility. (16508627)
2006
12
Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. (15542584)
2005
13
Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. (15048136)
2004
14
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. (10204802)
1999
15
Classification of intestinal T-cell neoplasms and their differential diagnosis. (9894471)
1999
16
Effects of intestinal bacteria on the development of colonic neoplasm II. Changes in the immunological environment. (10643943)
1999
17
Effects of intestinal bacteria on the development of colonic neoplasm: an experimental study. (10443953)
1999
18
The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions. (9684289)
1998
19
Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. (1646093)
1991
20
Three cases of small-intestinal neoplasm with unusual clinical features. (13059482)
1953
21
Three cases of small intestinal neoplasm. (13083804)
1953

Genetic Variations for Intestinal Neoplasm

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Expression for genes affiliated with Intestinal Neoplasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Neoplasm

Search GEO for disease gene expression data for Intestinal Neoplasm.

Pathways for genes affiliated with Intestinal Neoplasm

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 53Reactome, 29KEGG, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MMP2
2
Hide members
10.1BRAF
39.8APC, BRAF
49.8KRAS, BRAF
5
Hide members
9.8BRAF, KRAS
69.8KRAS, BRAF
7
Hide members
9.8KRAS, BRAF
89.8MMP9, MMP2
99.8MMP9, MMP2
109.8MMP9, MMP2
119.8MMP9, MMP2
12
Hide members
9.5APC, BRAF, KRAS
139.5MMP9, MMP2, APC
14
Development Endothelin-1/EDNRA signaling
Hide members
9.5MMP9, MMP2, KRAS
159.4KRAS, APC, PTGS2
169.3KRAS, PTGS2, BRAF
179.3MMP9, MMP2, PTGS2
189.1KRAS, APC, MMP9, PTGS2
199.0MMP9, BRAF, MMP2, KRAS
20
Hide members
9.0APC, KRAS, BRAF, PTGS2
21
Hide members
8.8MMP9, BRAF, BMP6, MMP2
22
Hide members
8.7BRAF, BMP6, MMP9, PTGS2
23
Hide members
8.4PTGS2, MMP9, MMP2, BMP6, BRAF
248.3BRAF, KRAS, MMP9, MMP2, APC, PTGS2

Compounds for genes affiliated with Intestinal Neoplasm

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1matrigel4410.4BRAF
2cilomilast4410.2MMP9
3cgs-27023a4410.1MMP2, MMP9
4flavanol4410.1MMP2, MMP9
5col 34410.1MMP2, MMP9
6methyl selenol4410.1MMP2, MMP9
7panitumumab44 49 1112.1BRAF, KRAS
8prinomastat4410.1MMP2, MMP9
9trapidil4410.1MMP2, MMP9
10tranilast4410.0BMP6, MMP2
11lercanidipine44 1111.0MMP2, MMP9
12ilomastat4410.0MMP2, MMP9
13halofuginone4410.0MMP2, BMP6
14gelfoam449.9MMP2, MMP9
15o6-methylguanine449.9APC, KRAS, BRAF
16crcs449.9BRAF, APC, KRAS
17nobiletin449.8MMP9, PTGS2
18latanoprost44 1110.8MMP2, MMP9
19pge2449.7PTGS2, MMP2, MMP9
20ciglitazone44 2810.7PTGS2, MMP2, MMP9
21ns 39844 5910.7MMP2, MMP9, PTGS2
22pioglitazone44 49 28 1112.6MMP2, MMP9, PTGS2
23pdtc449.6MMP2, MMP9, PTGS2
24irinotecan44 49 1111.6KRAS, PTGS2, BRAF
25hydroxyproline44 11 2411.6BMP6, MMP9, MMP2
26ag 1478449.6MMP2, MMP9, PTGS2
27tyrosine449.5APC, KRAS, BRAF
28celecoxib44 59 28 49 11 2414.5APC, MMP2, PTGS2, MMP9
29ibuprofen44 28 49 11 2413.5PTGS2, MMP2, BMP6
30gefitinib44 49 1111.4KRAS, MMP9, MMP2, PTGS2
31curcumin449.4MMP9, APC, MMP2, PTGS2
32silymarin449.2MMP9, MMP2, PTGS2, BMP6
33aspirin44 49 28 2412.2BMP6, MMP2, APC, PTGS2
34norepinephrine44 11 2411.2MMP9, BMP6, MMP2, APC
35troglitazone44 28 59 1112.2MMP9, PTGS2, MMP2, BMP6
36rapamycin449.2BRAF, APC, BMP6, KRAS
37wortmannin449.2APC, MMP9, KRAS, BRAF, MMP2
38herbimycin a44 5910.2PTGS2, MMP2, MMP9, BMP6
39paraffin449.2BRAF, MMP9, KRAS, APC, MMP2
4012-o-tetradecanoylphorbol 13-acetate449.2MMP2, MMP9, BRAF, BMP6
41atorvastatin44 49 28 11 2413.1MMP9, BMP6, MMP2
42p002449.1BRAF, KRAS, MMP9
43sb 20358044 599.8BRAF, MMP2, PTGS2, MMP9, BMP6
44pd 98,059448.8BMP6, BRAF, MMP2, MMP9, PTGS2
45phosphatidylinositol448.7MMP2, MMP9, BMP6, APC, BRAF, KRAS
46retinoic acid44 249.6BMP6, KRAS, MMP9, APC, BRAF, MMP2
47ly294002448.5BMP6, KRAS, MMP9, MMP2, PTGS2, BRAF
48vegf448.5BMP6, MMP9, MMP2, BRAF, KRAS, PTGS2
49serine448.2MMP2, BRAF, APC, KRAS, BMP6, MMP9
50estrogen448.2BRAF, APC, BMP6, MMP2, MMP9, KRAS

GO Terms for genes affiliated with Intestinal Neoplasm

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16Gene Ontology
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Biological processes related to Intestinal Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoid stimulusGO:0513849.2PTGS2, KRAS, BMP6
2embryo implantationGO:0075669.0PTGS2, MMP9, MMP2

Products for genes affiliated with Intestinal Neoplasm

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Sources for Intestinal Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet