MCID: INT069
MIFTS: 46

Intestinal Neoplasm malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Intestinal Neoplasm

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35MedlinePlus, 34MalaCards
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MedlinePlus:35 Your small intestine is part of your digestive system. it is a long tube that connects your stomach to your large intestine. intestinal cancer is rare, but eating a high-fat diet or having crohn's disease, celiac disease, or a history of colonic polyps can increase your risk. possible signs of small intestine cancer include abdominal pain weight loss for no reason blood in the stool a lump in the abdomen imaging tests that create pictures of the small intestine and the area around it can help diagnose intestinal cancer and show whether it has spread. surgery is the most common treatment. additional options include chemotherapy, radiation therapy, or a combination. nih: national cancer institute

MalaCards: Intestinal Neoplasm, also known as intestinal cancer, is related to gallbladder cancer and familial adenomatous polyposis. An important gene associated with Intestinal Neoplasm is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways are Post NMDA receptor activation events and Long-term depression. The compounds panitumumab and halofuginone have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and colon, and related mouse phenotypes are pigmentation and renal/urinary system.

Aliases & Classifications for Intestinal Neoplasm

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intestinal neoplasm 9 11
intestinal cancer 46 35
neoplasm of intestinal tract 9
intestinal carcinoma 46
intestinal neoplasms 63
intestinal tumors 9
intestine growth 9


External Ids:

Disease Ontology9 DOID:4610
NCIt41 C3141
SNOMED-CT59 126769007
MeSH36 D007414

Related Diseases for Intestinal Neoplasm

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Intestinal Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer29.9KRAS, APC
2familial adenomatous polyposis29.9APC, BRAF, KRAS
3colon cancer29.8APC, BRAF, MMP9, MMP2, BMP6, KRAS
4lung cancer29.7KRAS, MMP2, MMP9
5colorectal cancer29.6APC, BRAF, MMP9, MMP2, KRAS
6adenocarcinoma29.6APC, BRAF, MMP9, MMP2, BMP6, KRAS
7small intestine cancer, childhood10.1
8fibromatosis10.1APC
9small intestine cancer10.1
10stomach cancer10.1KRAS, APC
11gastric cancer, somatic10.1KRAS, APC
12rectal neoplasm10.1KRAS, APC
13cardiofaciocutaneous syndrome10.1KRAS, BRAF
14costello syndrome10.1KRAS, BRAF
15cystadenoma10.1BRAF, KRAS
16noonan syndrome10.1KRAS, BRAF
17short bowel syndrome10.1
18inflammatory bowel disease10.1
19endometrial carcinoma10.0BRAF, KRAS
20thyroid adenoma10.0APC, BRAF
21seminoma10.0KRAS, BRAF
22hypertrophic scars10.0MMP2, BMP6
23papillary thyroid carcinoma10.0BRAF, APC
24cholangiocarcinoma10.0BRAF, KRAS
25intraocular melanoma10.0MMP2, BRAF
26gastric adenocarcinoma10.0KRAS, APC
27glomerulosclerosis10.0MMP2, BMP6
28lynch syndrome10.0KRAS, BRAF, APC
29breast cancer10.0APC, BMP6, KRAS
30tongue cancer10.0MMP2, MMP9
31bone carcinoma10.0BMP6, MMP9
32conjunctivochalasis10.0MMP9, MMP2
33retinoblastoma10.0APC, BMP6, KRAS
34abdominal aortic aneurysm10.0MMP9, MMP2
35keratitis10.0MMP2, MMP9
36bladder carcinoma in situ10.0MMP2, MMP9
37adenoma10.0KRAS, BRAF, APC
38cervical cancer10.0KRAS, MMP2, BRAF
39idiopathic pulmonary fibrosis10.0MMP9, BMP6
40aneurysm10.0MMP2, MMP9
41anaplastic astrocytoma10.0MMP2, MMP9
42thyroid cancer10.0APC, BRAF
43periodontal disease10.0MMP2, MMP9
44oral cancer10.0MMP2, MMP9
45bladder carcinoma10.0MMP9, MMP2, KRAS
46pulmonary fibrosis10.0MMP9, MMP2, BMP6
47malignant glioma9.9BMP6, MMP2, MMP9
48prostate cancer9.9BMP6, MMP2, MMP9
49osteoarthritis9.9MMP9, MMP2, BMP6
50osteosarcoma9.9BMP6, MMP2, MMP9

Graphical network of the top 20 diseases related to Intestinal Neoplasm:



Diseases related to intestinal neoplasm

Symptoms for Intestinal Neoplasm

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Drugs & Therapeutics for Intestinal Neoplasm

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Intestinal Neoplasm

Drug clinical trials:

Search ClinicalTrials for Intestinal Neoplasm

Search NIH Clinical Center for Intestinal Neoplasm

Search CenterWatch for Intestinal Neoplasm

Genetic Tests for Intestinal Neoplasm

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Anatomical Context for Intestinal Neoplasm

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34MalaCards
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MalaCards organs/tissues related to Intestinal Neoplasm:

34
Small intestine, Testes, Colon

Animal Models for Intestinal Neoplasm or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Intestinal Neoplasm:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2APC, BRAF, KRAS
2MP:00053678.5APC, BRAF, MMP9, KRAS
3MP:00053818.4KRAS, MMP9, BRAF, APC
4MP:00053888.3BRAF, MMP9, MMP2, KRAS
5MP:00107718.2APC, BRAF, MMP9, KRAS
6MP:00028738.2APC, BRAF, MMP2, KRAS
7MP:00053898.0KRAS, BMP6, MMP9, BRAF, APC
8MP:00020068.0KRAS, MMP2, MMP9, BRAF, APC
9MP:00053918.0APC, BRAF, MMP9, MMP2, KRAS
10MP:00053697.9APC, BRAF, MMP9, MMP2, KRAS
11MP:00053857.9APC, BRAF, MMP9, MMP2, KRAS
12MP:00053977.9KRAS, MMP2, MMP9, BRAF, APC
13MP:00053877.8KRAS, MMP2, MMP9, BRAF, APC
14MP:00053907.8APC, BRAF, MMP9, MMP2, BMP6
15MP:00036317.8APC, BRAF, MMP9, MMP2, KRAS
16MP:00053767.6KRAS, MMP2, MMP9, BRAF, APC
17MP:00107687.6KRAS, MMP2, MMP9, BRAF, APC
18MP:00053787.4APC, BRAF, MMP9, MMP2, BMP6, KRAS

Publications for Intestinal Neoplasm

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Sources:
53PubMed
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Articles related to Intestinal Neoplasm:

idTitleAuthorsYear
1
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. (19208363)
2009
2
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. (17047044)
2006
3
Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. (1646093)
1991
4
Three cases of small-intestinal neoplasm with unusual clinical features. (13059482)
1953
5
Three cases of small intestinal neoplasm. (13083804)
1953

Variations for Intestinal Neoplasm

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Expression for genes affiliated with Intestinal Neoplasm

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Neoplasm

Search GEO for disease gene expression data for Intestinal Neoplasm.

Pathways for genes affiliated with Intestinal Neoplasm

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Sources:
51PathCards, 56Reactome, 31KEGG, 61Thomson Reuters, 52PharmGKB, 62Tocris Bioscience, 55R&D Systems, 54QIAGEN, 5Cell Signaling Technology, 39NCBI BioSystems Database, 13EMD Millipore
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Pathways related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5KRAS, BRAF
29.5BRAF, KRAS
3
Show member pathways
9.5BRAF, KRAS
49.5KRAS, BRAF
59.5KRAS, BRAF
6
Show member pathways
9.5BRAF, KRAS
7
Show member pathways
9.5KRAS, BRAF
89.5BRAF, KRAS
9
Show member pathways
9.5BRAF, KRAS
10
Show member pathways
9.5BRAF, KRAS
11
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.5BRAF, KRAS
12
Show member pathways
9.5KRAS, BRAF
13
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.5BRAF, KRAS
149.5KRAS, BRAF
159.5APC, BRAF
16
Show member pathways
RAC1 signaling pathway39
9.5APC, BRAF
179.1MMP9, BMP6
18
Show member pathways
9.1APC, BRAF, KRAS
19
Show member pathways
Signal transduction PTEN pathway61
9.1KRAS, BRAF, APC
209.0MMP9, MMP2
21
Show member pathways
9.0MMP9, MMP2
229.0MMP9, MMP2
239.0MMP9, MMP2
249.0MMP2, MMP9
259.0MMP9, MMP2
269.0MMP2, MMP9
279.0MMP2, MMP9
289.0MMP9, MMP2
299.0MMP2, MMP9
30
Show member pathways
9.0MMP2, MMP9
31
Show member pathways
9.0APC, BRAF, BMP6
328.8KRAS, MMP9, APC
338.6MMP2, MMP9, KRAS
34
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.6MMP9, MMP2, KRAS
35
Show member pathways
8.6MMP9, BRAF, BMP6
368.6APC, MMP9, MMP2
37
Show member pathways
8.5MMP2, MMP9, BRAF
38
Show member pathways
8.3APC, BRAF, MMP9, KRAS
398.1MMP9, MMP2, KRAS, BRAF
40
Show member pathways
Signaling Pathways in Glioblastoma39
8.1MMP9, MMP2, KRAS, BRAF
418.1APC, BRAF, MMP9, MMP2
42
Show member pathways
8.0MMP2, MMP9, BRAF, BMP6
43
Show member pathways
8.0MMP2, BMP6, BRAF, MMP9
447.6KRAS, MMP2, MMP9, BRAF, APC

Compounds for genes affiliated with Intestinal Neoplasm

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1panitumumab46 52 1211.9BRAF, KRAS
2halofuginone469.7BMP6, MMP2
3o6-methylguanine469.5KRAS, BRAF, APC
4crcs469.5APC, KRAS, BRAF
5flavanol469.4MMP9, MMP2
6cgs-27023a469.4MMP2, MMP9
7col 3469.4MMP9, MMP2
8methyl selenol469.4MMP9, MMP2
9prinomastat469.4MMP2, MMP9
10trapidil469.3MMP2, MMP9
11ilomastat469.3MMP2, MMP9
12lercanidipine46 1210.3MMP2, MMP9
13gelfoam469.2MMP2, MMP9
14cilomilast469.0MMP2, MMP9
15p002469.0MMP9, BRAF, KRAS
16rapamycin469.0BMP6, BRAF, APC, KRAS
17gefitinib46 52 1211.0MMP9, MMP2, KRAS
18tranilast468.9MMP9, MMP2, BMP6
19celecoxib46 62 30 52 25 1213.9APC, MMP9, MMP2
20latanoprost46 129.9MMP9, MMP2
21silymarin468.9BMP6, MMP2, MMP9
22hydroxyproline46 25 1210.9MMP9, MMP2, BMP6
23procollagen468.9BMP6, MMP9, MMP2
24atorvastatin46 52 30 25 1212.8BMP6, MMP9, MMP2
25troglitazone46 30 62 1211.7BMP6, MMP9, MMP2
26imatinib46 52 1210.7BRAF, KRAS, BMP6
27tgf beta1468.7MMP9, MMP2, BMP6
28herbimycin a46 629.7MMP9, MMP2, BMP6
29oligonucleotide468.6BRAF, APC, KRAS, BMP6
30progesterone46 30 62 25 1212.6BMP6, MMP2, BRAF, APC
31hyaluronic acid46 259.6MMP9, MMP2, BMP6
32curcumin468.6MMP2, MMP9, APC
33epinephrine46 25 1210.5APC, MMP2, BMP6, MMP9
34norepinephrine46 25 1210.5MMP2, MMP9, BMP6, APC
35pge2468.4BMP6, MMP9, APC, MMP2
36matrigel468.4MMP2, BMP6, MMP9, BRAF
3712-o-tetradecanoylphorbol 13-acetate468.4MMP2, BRAF, MMP9, BMP6
38sb 20358046 629.4BRAF, MMP9, MMP2, BMP6
39pd 98,059468.4BMP6, BRAF, MMP2, MMP9
40cycloheximide468.4APC, BMP6, MMP2, MMP9
41aspartate468.3MMP2, BMP6, BRAF, MMP9
42wortmannin468.1APC, KRAS, MMP9, MMP2, BRAF
43paraffin468.1APC, BRAF, MMP9, MMP2, KRAS
44ly294002468.0MMP2, MMP9, BRAF, BMP6, KRAS
45vegf468.0BMP6, KRAS, MMP2, MMP9, BRAF
46phosphatidylinositol467.6BRAF, APC, MMP9, KRAS, MMP2, BMP6
47estrogen467.6KRAS, BMP6, MMP2, BRAF, APC, MMP9
48retinoic acid46 258.6KRAS, APC, BRAF, MMP9, MMP2, BMP6
49serine467.6APC, BRAF, MMP2, BMP6, KRAS, MMP9
50tyrosine467.6MMP9, BRAF, MMP2, BMP6, APC, KRAS

GO Terms for genes affiliated with Intestinal Neoplasm

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17Gene Ontology
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Biological processes related to Intestinal Neoplasm according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:0001869.7KRAS, BRAF
2response to glucocorticoidGO:0513849.6KRAS, BMP6
3kidney developmentGO:0018229.4BMP6, APC
4leukocyte migrationGO:0509009.2KRAS, MMP9
5embryo implantationGO:0075669.2MMP2, MMP9
6collagen catabolic processGO:0305749.0MMP9, MMP2
7extracellular matrix disassemblyGO:0226178.7MMP2, MMP9

Molecular functions related to Intestinal Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.0MMP2, MMP9

Products for genes affiliated with Intestinal Neoplasm

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intestinal Neoplasm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet