MCID: INT070
MIFTS: 46

Intestinal Obstruction malady

Fetal category

Summaries for Intestinal Obstruction

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 An intestinal obstruction occurs when food or stool cannot move through the intestines. the obstruction can be complete or partial. there are many causes. the most common are adhesions, hernias, cancers, and certain medicines. symptoms include severe abdominal pain or cramping vomiting bloating loud bowel sounds swelling of the abdomen inability to pass gas constipation a complete intestinal obstruction is a medical emergency. it often requires surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Intestinal Obstruction is related to cystic fibrosis and teratoma. An important gene associated with Intestinal Obstruction is GDNF (glial cell derived neurotrophic factor). The drugs mineral oil and mineral oil, light and the compounds cftrinh 172 and dcpib have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and digestive/alimentary.

Wikipedia:64 Bowel obstruction (or intestinal obstruction) is a mechanical or functional obstruction of the... more...

Aliases & Classifications for Intestinal Obstruction

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Intestinal Obstruction

Sources:
17GeneCards, 18GeneDecks
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Diseases in the intestinal pseudo-obstruction family:

intestinal obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis30.8CFTR, GUCY2C
2teratoma30.3KRT7
3pseudomyxoma peritonei30.2KRT20, KRT7, CDX2
4adenoma30.2APOLD1, GUCY2C, EDN3, CDX2, GDNF, KRT7
5ulcerative colitis29.9NOD2
6rectal prolapse29.9APOLD1, CFTR
7mucinous cystadenocarcinoma29.9KRT7, KRT20
8hirschsprung's disease29.9GDNF, NRTN, EDN3, SOX10
9adenocarcinoma29.9GUCY2C, CDX2, KRT7, KRT20
10colorectal cancer29.9GUCY2C, CDX2, KRT7, KRT20
11ileus10.6
12intestinal volvulus10.5
13meconium ileus10.4
14superior mesenteric artery syndrome10.4
15intussusception10.4
16ascariasis10.3
17n syndrome10.3
18wandering spleen10.3
19meconium ileus in cystic fibrosis10.3
20paralytic ileus10.2
21intestinal atresia10.2
22micro syndrome10.2
23megacystis microcolon intestinal hypoperistalsis syndrome10.2
24malignant peritoneal mesothelioma10.2
25anisakiasis10.2
26meckel's diverticulum10.2
27gastrointestinal stromal tumor10.2
28appendicitis10.2
29adult syndrome10.2
30intestinal tuberculosis10.2
31congenital diaphragmatic hernia10.2
32small intestinal sarcoma10.2
33tuberculosis10.2
34enterocele10.1
35acute myeloid leukemia10.1
36giant hemangioma10.1
37melas syndrome10.1
38eosinophilic gastroenteritis10.1
39myeloid sarcoma10.1
40pneumatosis cystoides intestinalis10.1
41mesenteric vascular occlusion10.1
42cystic lymphangioma10.1
43acute leukemia10.1
44annular pancreas10.1
45neonatal ovarian cyst10.1
46rare endometriosis10.1
47pancreatitis10.0CFTR
48esophagitis10.0CDX2
49sinusitis10.0CFTR
50pituitary adenoma10.0GDNF

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to intestinal obstruction

Clinical Features for Intestinal Obstruction

Drugs & Therapeutics for Intestinal Obstruction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Intestinal Obstruction

Drug clinical trials:

Search ClinicalTrials for Intestinal Obstruction

Search NIH Clinical Center for Intestinal Obstruction

Search CenterWatch for Intestinal Obstruction

Inferred drug relations via UMLS61/NDF-RT41:

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Genetic Tests for Intestinal Obstruction

Anatomical Context for Intestinal Obstruction

Animal Models for Intestinal Obstruction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Intestinal Obstruction:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.8SOX10, MB, GUCY2C, FLNA, HDC, CDX2
2MP:00053818.5SOX10, GUCY2C, EDN3, FLNA, NRTN, CDX2

Publications for Intestinal Obstruction

Sources:
51PubMed
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Articles related to Intestinal Obstruction:

(show top 50)    (show all 1020)
idTitleAuthorsYear
1
Postoperative Complications Leading to Death after Coagulum Pyelolithotomy in a Tetraplegic Patient: Can We Prevent Prolonged Ileus, Recurrent Intestinal Obstruction due to Adhesions Requiring Laparotomies, Chest Infection Warranting Tracheostomy, and Mechanical Ventilation? (23533931)
2013
2
Malrotation with transverse colon volvulus in early pregnancy: a rare cause for acute intestinal obstruction. (23964051)
2013
3
Obturator hernia: a rare case of acute mechanical intestinal obstruction. (23738179)
2013
4
Distal intestinal obstruction syndrome in cystic fibrosis: presentation, outcome and management in a tertiary hospital (2007-2012). (24237857)
2013
5
Assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction using cine-MRI. (23511458)
2013
6
Distal intestinal obstruction syndrome: a mimic of acute appendicitis. (23345312)
2013
7
Possible antistenotic effect of tranilast in a patient with small bowel tuberculosis to prevent intestinal obstruction due to stenosis progression by antituberculous chemotherapy. (23363021)
2013
8
Intestinal obstruction caused by potato bezoar in infancy: a report of three cases. (22503265)
2012
9
Segmental ileal dilatation: an unsuspected cause of neonatal intestinal obstruction. (23025063)
2012
10
Xanthogranulomatous salpingitis and oophoritis associated with endometriosis and uterine leiomyoma presenting as intestinal obstruction. (22568924)
2012
11
Postoperative adhesive intestinal obstruction: The role of intestinal stenting. (22279359)
2012
12
An epidemiologic survey of chronic intestinal pseudo-obstruction and evaluation of the newly proposed diagnostic criteria. (22710349)
2012
13
Spectral analysis of bowel sounds in intestinal obstruction using an electronic stethoscope. (22969233)
2012
14
Presacral parachordoma causing intestinal obstruction in a patient with renal failure: Report of a case. (21922364)
2011
15
Phytobezoar as a cause of intestinal obstruction. (21826548)
2011
16
Cecal duplication cyst presenting as acute intestinal obstruction in an infant. (22953278)
2011
17
Superior mesenteric artery syndrome: a rare cause of complete intestinal obstruction in neonates. (22152903)
2011
18
Stone vomiting and intestinal obstruction in a patient with gallstones. (21375818)
2010
19
Effect of Dachengqi decoction on NF-kappaB p65 expression in lung of rats with partial intestinal obstruction and the underlying mechanism. (20407877)
2010
20
Obturator hernia: an unusual cause of intestinal obstruction. (19278398)
2009
21
Congenital intrinsic intestinal obstruction in a Caribbean country. (20187513)
2009
22
Angiotropic large cell lymphoma presenting as intestinal obstruction. (17628802)
2008
23
Percutaneous endoscopic gastrostomy for gastric decompression after repeated intestinal obstruction after open abdominal surgery. (19098670)
2008
24
Hydrometrocolpos from a low vaginal atresia: an uncommon cause of neonatal intestinal and urinary obstruction. (19858664)
2008
25
Pheochromocytoma presented as intestinal pseudo-obstruction and hyperamylasemia. (18926378)
2008
26
Intestinal obstruction and ileus: role of computed tomography scan in diagnosis and management. (18186373)
2007
27
Intestinal obstruction due to spontaneous intramural hematoma of the small intestine during warfarin use: a report of two cases. (17823563)
2007
28
Neonatal intestinal obstruction simulating meconium ileus in infants with long-segment intestinal aganglionosis: radiographic findings that prompt the need for rectal biopsy. (16341713)
2006
29
Etiology of intestinal obstruction in patients without a prior history of laparotomy or a detectable external hernia on physical examination. (16967678)
2006
30
Strongyloides stercoralis mesenteric lymphadenopathy: clue to the etiopathogenesis of intestinal pseudo-obstruction in HIV-infected patients. (16844562)
2006
31
Acute gastro-intestinal obstruction as a late presentation of congenital diaphragmatic hernia. A report of three cases. (17017700)
2006
32
Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. (17030173)
2006
33
Intestinal pseudo-obstruction caused by diltiazem in a neutropenic patient. (16144882)
2005
34
An unusual cause of rectal bleeding and intestinal obstruction in a child with peripheral vascular malformations. (15806421)
2005
35
Deranged smooth muscle alpha-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series. (15479676)
2004
36
Intestinal anisakiasis mimicking intestinal obstruction. (12730035)
2003
37
Modified multivisceral transplantation without a liver graft for Gardner/Desmoid syndrome and chronic intestinal pseudo-obstruction. (12034234)
2002
38
Chronic Idiopathic Intestinal Pseudo-obstruction. (11096594)
2000
39
Intestinal pseudo-obstruction as a paraneoplastic manifestation of malignant thymoma. (9317092)
1997
40
Chronic intestinal pseudo-obstruction in childhood: progress in diagnosis and treatment. (8578242)
1995
41
Primary chronic intestinal pseudo-obstruction--an update. (8170894)
1994
42
Secondary effects of prolonged intestinal obstruction on the enteric nervous system in the rat. (7905922)
1993
43
Predicting the clinical response to cisapride in children with chronic intestinal pseudo-obstruction. (8503375)
1993
44
Intestinal pseudo-obstruction following the use of enteral charcoal and sorbitol and mechanical ventilation with papaveretum sedation for theophylline poisoning. (1536699)
1992
45
Intestinal obstruction due to diffuse peritoneal fibrosis at 2 years after the successful treatment of malignant peritoneal mesothelioma with intraperitoneal mitoxantrone. (1551180)
1992
46
Surreptitious ipecac administration simulating intestinal pseudo-obstruction. (2567141)
1989
47
Comparison of duodenitis/proximal jejunitis and small intestinal obstruction in horses: 68 cases (1977-1985). (3679978)
1987
48
Syndrome of Intestinal Pseudo-obstruction. (20789407)
1962
49
Intestinal tuberculosis with stenosis and obstruction. (14913704)
1952
50
Myoma of the small intestine causing intestinal obstruction. (20257908)
1947

Genetic Variations for Intestinal Obstruction

Expression for genes affiliated with Intestinal Obstruction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Obstruction

Search GEO for disease gene expression data for Intestinal Obstruction.

Pathways for genes affiliated with Intestinal Obstruction

Compounds for genes affiliated with Intestinal Obstruction

Sources:
60Tocris Bioscience, 45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Intestinal Obstruction according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1cftrinh 1726010.4CFTR, CLCA3P
2dcpib6010.4CFTR, CLCA3P
3chromanol 293b45 60 2912.3CLCA3P, CFTR
4lonidamine45 6011.3CLCA3P, CFTR
5carnosine45 2411.2MB, HDC
6levodopa45 1111.1GDNF, HDC, EDN3
7histidine459.9HDC, EDN3, MB, MVK
8acetylcholine45 50 29 11 2413.9MB, EDN3, NRTN, GDNF, CFTR
9mucicarmine459.8KRT20, KRT7
10aspartate459.8MB, EDN3, HDC, GDNF, CFTR
11nppb45 60 2911.8CFTR, CLCA3P
12formaldehyde45 2410.8EDN3, CFTR, KRT7, KRT20
13norepinephrine45 11 2411.8MB, EDN3, GDNF, CFTR
14glutamate459.7CFTR, GDNF, NRTN, HDC, EDN3, MB
15dopamine45 29 11 2412.5CFTR, MB, EDN3, FLNA, HDC, NRTN
16alanine459.5MVK, MB, EDN3, FLNA, HDC, GDNF
17paraffin459.4MB, GUCY2C, CDX2, CFTR, KRT7, KRT20
18testosterone45 60 11 2412.4KRT20, KRT7, CFTR, EDN3, MB
19serine459.1MVK, MB, EDN3, FLNA, GDNF, CFTR
20tyrosine458.7GUCY2C, EDN3, FLNA, HDC, NRTN, CDX2

GO Terms for genes affiliated with Intestinal Obstruction

Sources:
16Gene Ontology
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Biological processes related to Intestinal Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enteric nervous system developmentGO:04848410.1GDNF, SOX10
2neural crest cell migrationGO:0017559.5GDNF, NRTN, EDN3, SOX10

Products for genes affiliated with Intestinal Obstruction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intestinal Obstruction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet