MCID: INT070
MIFTS: 54

Intestinal Obstruction malady

Fetal diseases, Gastrointestinal diseases categories

Summaries for Intestinal Obstruction

About this section
Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 An intestinal obstruction occurs when food or stool cannot move through the intestines. the obstruction can be complete or partial. there are many causes. the most common are adhesions, hernias, cancers, and certain medicines. symptoms include severe abdominal pain or cramping vomiting bloating loud bowel sounds swelling of the abdomen inability to pass gas constipation a complete intestinal obstruction is a medical emergency. it often requires surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Intestinal Obstruction is related to cystic fibrosis and peritonitis. An important gene associated with Intestinal Obstruction is GDNF (glial cell derived neurotrophic factor). The drugs mineral oil and mineral oil, light and the compounds cftrinh 172 and dcpib have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and kidney, and related mouse phenotypes are growth/size and digestive/alimentary.

Wikipedia:63 Bowel obstruction (or intestinal obstruction) is a mechanical or functional obstruction of the... more...

Aliases & Classifications for Intestinal Obstruction

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
See all sources

Related Diseases for Intestinal Obstruction

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Intestinal Pseudo-Obstruction family:

intestinal obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis30.8CFTR, GUCY2C
2peritonitis30.7MB
3ovarian cancer30.4EDN3, KRT7, MB
4constipation30.2GUCY2C, APOLD1
5pseudomyxoma peritonei30.2CDX2, KRT7, KRT20
6colon cancer30.0CFTR, CDX2, GUCY2C, KRT20
7adenoma30.0KRT20, EDN3, CDX2, GUCY2C, APOLD1, GDNF
8pancreatitis29.8CFTR
9esophagitis29.8CDX2
10colon adenocarcinoma29.8KRT20
11ulcerative colitis29.8NOD2
12lung cancer29.8KRT7
13rectal prolapse29.8APOLD1, CFTR
14mucinous cystadenocarcinoma29.8KRT7, KRT20
15diarrhea29.8CFTR, APOLD1, GUCY2C
16hirschsprung's disease29.8GDNF, SOX10, EDN3, NRTN
17adenocarcinoma29.8GUCY2C, CDX2, KRT20, KRT7
18colorectal cancer29.8KRT20, KRT7, GUCY2C, CDX2
19breast cancer29.8NOD2, CDX2, KRT7, HDC, EDN3, CFTR
20melanoma29.8SOX10, EDN3, FLNA, HDC, CDX2, CD8A
21meckel's diverticulum10.5
22intestinal volvulus10.5
23endometriosis10.4
24intussusception10.4
25lipoma10.4
26superior mesenteric artery syndrome10.4
27intestinal perforation10.4
28ascariasis10.3
29duodenitis10.3
30duodenal obstruction10.3
31intestinal disease10.3
32sarcoma10.3
33paralytic ileus10.3
34meconium ileus10.3
35endometriosis of intestine10.2
36intestinal atresia10.2
37malignant peritoneal mesothelioma10.1
38anisakiasis10.1
39gastrointestinal stromal tumor10.1
40appendicitis10.1
41adult syndrome10.1
42intestinal tuberculosis10.1
43congenital diaphragmatic hernia10.1
44small intestinal sarcoma10.1
45small intestine cancer10.1
46tuberculosis10.1
47burns10.1
48crohn's disease10.1
49enterocele10.1
50acute myeloid leukemia10.1

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to intestinal obstruction

Clinical Features for Intestinal Obstruction

About this section

Drugs & Therapeutics for Intestinal Obstruction

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intestinal Obstruction

Drug clinical trials:

Search ClinicalTrials for Intestinal Obstruction

Search NIH Clinical Center for Intestinal Obstruction

Search CenterWatch for Intestinal Obstruction

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Genetic Tests for Intestinal Obstruction

About this section

Anatomical Context for Intestinal Obstruction

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Intestinal Obstruction:

32
Small intestine, Colon, Kidney, Smooth muscle, Lung, Liver, Spleen, Pancreas, Myeloid, Appendix, Breast, Monocytes, Thyroid, Uterus, Lymph node, Brain, Prostate, Testis

Animal Models for Intestinal Obstruction or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Intestinal Obstruction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.8SOX10, MB, GUCY2C, FLNA, HDC, CDX2
2MP:00053818.5SOX10, GUCY2C, EDN3, FLNA, NRTN, CDX2

Publications for Intestinal Obstruction

About this section
Sources:
50PubMed
See all sources

Articles related to Intestinal Obstruction:

(show top 50)    (show all 1068)
idTitleAuthorsYear
1
Malrotation with transverse colon volvulus in early pregnancy: a rare cause for acute intestinal obstruction. (23964051)
2013
2
Effects of biliary drainage on the intestinal barrier function in obstructive jaundice. (23933919)
2013
3
Non-transplantation surgical approach for chronic intestinal pseudo-obstruction: analysis of 63 adult consecutive cases. (23895212)
2013
4
Case report of small bowel obstruction caused by small intestinal metastasis of bilateral breast cancer. (24137245)
2013
5
Retraction of article. Eugen Florin Georgescu, Ion Vasile, Ana Claudia Georgescu. Intestinal pseudo-obstruction--a rare condition with heterogeneous etiology and unpredictable outcome. A case report. J Gastrointestin Liver Dis. March 2008; 17(1): 77-80. (22720315)
2012
6
Unusual cause of intestinal obstruction: left paraduodenal hernia. (22474457)
2012
7
An adult case of intestinal nonrotation causing distal duodenal obstruction. (22856479)
2012
8
Neonatal intestinal obstruction secondary to a floppy Meckel's diverticulum successfully treated by minimal access surgery. (23242081)
2012
9
Acute appendicitis mimicking intestinal obstruction in a patient with cystic fibrosis. (23089694)
2012
10
Surgical treatment of Kawasaki disease with intestinal pseudo-obstruction. (20949336)
2011
11
Cecal volvulus as a rare cause of intestinal obstruction. (22166741)
2011
12
Superior mesenteric artery syndrome: a rare cause of complete intestinal obstruction in neonates. (22152903)
2011
13
Incidence of emergency intestinal pseudo-obstruction in Parkinson's disease. (22188082)
2011
14
Urgent treatment of patients with intestinal obstruction. (21560895)
2011
15
Intestinal obstruction caused by splenosis at the rectosigmoid junction, mimicking malignant pelvic tumor. (21837604)
2011
16
Postoperative intestinal obstruction. (20647889)
2010
17
Successful treatment of a female with chronic pseudo-intestinal obstruction with sympathomimetic amines and thyroid hormone replacement. (21077500)
2010
18
Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility. (19136514)
2009
19
Small intestinal obstruction due to phytobezoar: a case report. (20062741)
2009
20
Functional status, health-related quality of life and symptom severity in patients with chronic intestinal pseudo-obstruction and enteric dysmotility. (19308798)
2009
21
Percutaneous endoscopic gastrostomy for gastric decompression after repeated intestinal obstruction after open abdominal surgery. (19098670)
2008
22
Intestinal obstruction: trends in imaging utilization and their influence in its rising hospital bill. (18427845)
2008
23
Acute intestinal obstruction after endoscopic submucosal dissection: report of a case. (18536969)
2008
24
Acute intestinal pseudo-obstruction after induction treatment of relapsed acute promyelocytic leukemia with arsenic trioxide. (17635008)
2008
25
Chronic intestinal pseudo-obstruction due to buserelin-induced formation of anti-GnRH antibodies. (17241858)
2007
26
Hyperbaric oxygen therapy for the treatment of postoperative paralytic ileus and adhesive intestinal obstruction associated with abdominal surgery: experience with 626 patients. (18251130)
2007
27
Immature mesenteric teratoma causing intestinal obstruction. (17337839)
2007
28
A rare cause of intestinal obstruction: incarcerated femoral hernia, strangulated obturator hernia. (16520887)
2006
29
Chronic primary intestinal pseudo-obstruction from visceral myopathy. (16792457)
2006
30
Superior mesenteric artery syndrome: an uncommon cause of upper intestinal obstruction. (17007758)
2006
31
Surgery in intestinal pseudo-obstruction: pro. (16131976)
2005
32
Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. (15057744)
2004
33
Childhood intestinal obstruction in Northwestern Nigeria. (15730090)
2004
34
Surgical treatment of chronic intestinal pseudo-obstruction: report of three cases. (12560910)
2003
35
Nutritional management of pediatric patients with chronic intestinal pseudo-obstruction syndrome. (11321423)
2001
36
Chronic intestinal pseudo-obstruction: the clinical perspective. (11321412)
2001
37
Fludarabine induced intestinal pseudo-obstruction: case report and literature review. (10912495)
2000
38
The application of radio-opaque markers prior to ileostomy in an infant with chronic intestinal pseudo-obstruction: report of a case. (9505323)
1998
39
Intestinal pseudo-obstruction syndrome in a child with myotonic dystrophy. (8834995)
1996
40
Small bowel resection for relief of chronic intestinal pseudo-obstruction. (7541935)
1995
41
Autonomic dysfunction in patients with chronic intestinal pseudo-obstruction. (8324379)
1993
42
Intestinal pseudo-obstruction with deficient smooth muscle alpha-actin. (1468752)
1992
43
What is your diagnosis? Obstructive small intestinal disease. (2365632)
1990
44
Amitriptyline overdose complicated by intestinal pseudo-obstruction and caecal perforation. (2616439)
1989
45
Acute intestinal pseudo-obstruction (Ogilvie's syndrome) complicating radical retropubic prostatectomy. (2709511)
1989
46
Intestinal pseudo-obstruction: a new complication of oesophageal sclerotherapy. (3083982)
1986
47
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979
48
Intestinal obstruction due to a wandering spleen. (707467)
1978
49
Intestinal pseudo-obstruction. (676971)
1978
50
Intestinal obstruction due to mesenteric vascular occlusion. (5037886)
1972

Genetic Variations for Intestinal Obstruction

About this section

Expression for genes affiliated with Intestinal Obstruction

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intestinal Obstruction

Search GEO for disease gene expression data for Intestinal Obstruction.

Pathways for genes affiliated with Intestinal Obstruction

About this section

Compounds for genes affiliated with Intestinal Obstruction

About this section
Sources:
59Tocris Bioscience, 44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB
See all sources

Compounds related to Intestinal Obstruction according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1cftrinh 1725910.4CFTR, CLCA3P
2dcpib5910.4CFTR, CLCA3P
3chromanol 293b44 59 2812.3CLCA3P, CFTR
4lonidamine44 5911.3CLCA3P, CFTR
5carnosine44 2411.2MB, HDC
6levodopa44 1111.1HDC, GDNF, EDN3
7histidine449.9EDN3, MVK, HDC, MB
8acetylcholine44 49 28 11 2413.9MB, CFTR, GDNF, NRTN, EDN3
9mucicarmine449.8KRT20, KRT7
10aspartate449.8MB, EDN3, GDNF, CFTR, HDC
11nppb44 59 2811.8CLCA3P, CFTR
12formaldehyde44 2410.8KRT20, CFTR, EDN3, KRT7
13norepinephrine44 11 2411.8CFTR, EDN3, GDNF, MB
14glutamate449.7GDNF, CFTR, NRTN, HDC, EDN3, MB
15dopamine44 28 11 2412.5MB, EDN3, FLNA, HDC, NRTN, GDNF
16alanine449.5GDNF, FLNA, EDN3, MB, MVK, CFTR
17paraffin449.4CFTR, CDX2, MB, KRT7, GUCY2C, KRT20
18testosterone44 59 11 2412.4MB, KRT7, CFTR, KRT20, EDN3
19serine449.1EDN3, CFTR, MB, MVK, NOD2, FLNA
20tyrosine448.7GDNF, CDX2, CD8A, NRTN, HDC, FLNA

GO Terms for genes affiliated with Intestinal Obstruction

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Intestinal Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enteric nervous system developmentGO:04848410.1GDNF, SOX10
2neural crest cell migrationGO:0017559.5GDNF, NRTN, EDN3, SOX10

Products for genes affiliated with Intestinal Obstruction

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intestinal Obstruction

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet