MCID: INT070
MIFTS: 53

Intestinal Obstruction malady

Fetal diseases, Gastrointestinal diseases, Rare diseases, Neuronal diseases categories

Aliases & Classifications for Intestinal Obstruction

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Summaries for Intestinal Obstruction

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MedlinePlus:32 An intestinal obstruction occurs when food or stool cannot move through the intestines. the obstruction can be complete or partial. there are many causes. the most common are adhesions, hernias, cancers, and certain medicines. symptoms include severe abdominal pain or cramping vomiting bloating loud bowel sounds swelling of the abdomen inability to pass gas constipation a complete intestinal obstruction is a medical emergency. it often requires surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Intestinal Obstruction is related to meconium ileus and pseudomyxoma peritonei. An important gene associated with Intestinal Obstruction is GDNF (glial cell derived neurotrophic factor), and among its related pathways is Biogenic Amine Synthesis. The drugs mineral oil and mineral oil, light and the compounds bq 3020 and pd 142893 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and colon, and related mouse phenotypes are respiratory system and tumorigenesis.

Related Diseases for Intestinal Obstruction

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Diseases in the Intestinal Obstruction family:

Intestinal Pseudo-Obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1meconium ileus31.4GUCY2C
2pseudomyxoma peritonei30.9KRT7, KRT20, CDX2
3familial mediterranean fever, ar30.7NOD2, MVK
4constipation30.7APOLD1, GUCY2C
5multiple endocrine neoplasia iia30.6GDNF, RET
6mucinous cystadenocarcinoma30.6KRT7, KRT20
7rectal prolapse30.6APOLD1, CFTR
8waardenburg's syndrome30.3RET, EDN3, EDNRB
9colorectal cancer30.2CFTR, GUCY2C, KRT20, CDX2
10diarrhea30.0CFTR, GUCY2C, APOLD1, ALB
11hirschsprung disease 129.9GDNF, EDNRB, EDN3, RET, ACHE
12adenocarcinoma29.6EDNRB, GUCY2C, ESR1, KRT7, KRT20, CDX2
13melanoma29.6HDC, GDNF, EDNRB, EDN3, CFTR, MB
14breast cancer29.4EDNRB, EDN3, ESR1, KRT7, KRT20, CDX2
15adenoma29.3GDNF, EDNRB, EDN3, GUCY2C, APOLD1, RET
16ileus10.6
17cystic fibrosis10.6
18peritonitis10.6
19medullary thyroid carcinoma, familial10.6GDNF
20meckel's diverticulum10.5
21inverted papilloma10.5KRT20
22anuria10.5MB
23lipoma10.5
24endometriosis10.5
25superior mesenteric artery syndrome10.4
26signet ring cell adenocarcinoma10.4KRT7, KRT20
27ovarian brenner tumor10.4KRT7, KRT20
28pyoderma gangrenosum10.4MVK, NOD2
29paget disease, extramammary10.4KRT7, KRT20
30pancreatic ductal carcinoma10.4KRT7, KRT20
31acute poststreptococcal glomerulonephritis10.4EDNRB
32blau syndrome10.4MVK, NOD2
33hepatorenal syndrome10.4ALB
34varicose veins10.4ALB
35intussusception10.4
36wandering spleen10.4
37bladder adenocarcinoma10.4KRT7, KRT20, CDX2
38ascariasis10.3
39duodenitis10.3
40sarcoma10.3
41intestinal obstruction in the newborn due to guanylate cyclase 2c deficiency10.3
42bronchiolo-alveolar adenocarcinoma10.3KRT7, KRT20, CDX2
43nutritional deficiency disease10.3CFTR, ALB
44barrett esophagus/esophageal adenocarcinoma10.3CDX2, KRT20, KRT7
45cholangiocarcinoma10.3CDX2, KRT20, KRT7
46renal dysplasia10.3RET, GDNF
47malignant mixed mullerian tumor10.3MB, KRT7
48neuroma10.3RET, GDNF
49gastrointestinal stromal tumor10.3
50anisakiasis10.3

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to intestinal obstruction

Symptoms for Intestinal Obstruction

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Drugs & Therapeutics for Intestinal Obstruction

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Drug clinical trials:

Search ClinicalTrials for Intestinal Obstruction

Search NIH Clinical Center for Intestinal Obstruction

Inferred drug relations via UMLS61/NDF-RT40:

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Genetic Tests for Intestinal Obstruction

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Anatomical Context for Intestinal Obstruction

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MalaCards organs/tissues related to Intestinal Obstruction:

31
Small intestine, Kidney, Colon, Spleen, Lung, Pancreas, Myeloid, Appendix, Smooth muscle, Breast, Brain, Liver, Thyroid, Prostate, Testis, Monocytes

Animal Models for Intestinal Obstruction or affiliated genes

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Publications for Intestinal Obstruction

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Articles related to Intestinal Obstruction:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Intestinal Obstruction in a 3-Year-Old Girl by Ascaris lumbricoides Infestation: Case Report and Review of the Literature. (25906092)
2015
2
An unexpected cause of intestinal obstruction in an uncommon site. (25529807)
2015
3
Intestinal obstruction due to internal supravesical hernia. (25263273)
2014
4
A patient with hematochezia and intestinal obstruction. (25349601)
2014
5
Gallstone ileus: a rare cause of intestinal obstruction -- case report and literature review. (24157124)
2013
6
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
7
Postoperative Complications Leading to Death after Coagulum Pyelolithotomy in a Tetraplegic Patient: Can We Prevent Prolonged Ileus, Recurrent Intestinal Obstruction due to Adhesions Requiring Laparotomies, Chest Infection Warranting Tracheostomy, and Mechanical Ventilation? (23533931)
2013
8
Distribution of interstitial cells of Cajal in Meriones unguiculatus and alterations in the development of incomplete intestinal obstruction. (23690145)
2013
9
Subacute intestinal obstruction: an enigma revisited. (23550197)
2013
10
Acquired Ileal Atresia Induced by Adhesive Intestinal Obstruction. (24248986)
2013
11
Thymoquinone ameliorates bacterial translocation and inflammatory response in rats with intestinal obstruction. (22750428)
2012
12
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
13
The role of ultrasound in the management of intestinal obstruction. (22416163)
2012
14
Celiac disease presenting with intestinal obstruction: report of two cases. (22965520)
2012
15
Neonatal adrenal hemorrhage presenting as intestinal obstruction. (21992912)
2011
16
Aetiological factors in mechanical intestinal obstruction. (23272428)
2011
17
Severe type of adult jejunal intussusception caused by long intestinal tube in a patient with intestinal obstruction due to cecal carcinoma. (22688937)
2011
18
Presacral parachordoma causing intestinal obstruction in a patient with renal failure: Report of a case. (21922364)
2011
19
Late intestinal obstruction due to an intestinal volvulus in a pregnant patient with a previous Roux-en-Y gastric bypass. (19319613)
2010
20
Intestinal obstruction caused by incarcerated posterolateral right diaphragmatic hernia. (21142393)
2010
21
A rare cause of partial intestinal obstruction in a child: colonic lithobezoar. (21686451)
2009
22
Surgery for the palliation of intestinal obstruction in advanced abdominal malignancy. (20087548)
2009
23
A case of congenital diaphragmatic adult hernia presenting as acute intestinal obstruction. (23133146)
2009
24
Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction. (19206013)
2009
25
Etiological spectrum of acute intestinal obstruction. (20061589)
2009
26
Angiotropic large cell lymphoma presenting as intestinal obstruction. (17628802)
2008
27
Intestinal obstruction in children due to Ascariasis: a tertiary health centre experience. (19858669)
2008
28
Intestinal obstruction in an autistic adolescent. (19240672)
2008
29
Intestinal obstruction from inspissated barium (Barolith): a systematic review of all cases from 1950 to 2006. (18355376)
2008
30
Rapidly fatal clozapine-induced intestinal obstruction without prior warning signs. (19031643)
2008
31
Rare cause of intestinal obstruction after laparoscopic radical nephrectomy: internal herniation via a mesenteric defect. (18597821)
2008
32
Mesh migration following obturator hernia repair presenting as a bezoar inducing small intestinal obstruction. (17375259)
2008
33
Percutaneous endoscopic gastrostomy for gastric decompression after repeated intestinal obstruction after open abdominal surgery. (19098670)
2008
34
Gastric dilation and intestinal obstruction in 76 rabbits. (17890769)
2007
35
Small intestinal obstruction by a Peutz-Jeghers polyp--double-balloon enteroscopic removal. (17614040)
2007
36
Segmental defect of intestinal musculature: a rare cause of intestinal obstruction in children. (16899190)
2006
37
Neonatal intestinal obstruction simulating meconium ileus in infants with long-segment intestinal aganglionosis: radiographic findings that prompt the need for rectal biopsy. (16341713)
2006
38
Acute small intestinal obstruction associated with Parascaris equorum infection in young horses: 25 cases (1985-2004). (17151735)
2006
39
Gestational intestinal obstruction: a case report and review of literature. (16408180)
2006
40
An unusual cause of subacute intestinal obstruction. (16531532)
2006
41
Chronic intestinal obstruction due to rectosigmoid endometriosis: a case report. (16805176)
2006
42
Intestinal obstruction due to rectal endometriosis. (16358167)
2005
43
Management and prognosis of colon cancer in patients with intestinal obstruction or peritonitis: a French population-based study. (15917717)
2005
44
Spectrum of causes of intestinal obstruction in adult Nigerian patients. (16035380)
2005
45
Palliative care for intestinal obstruction in recurrent ovarian cancer: a multivariate analysis. (16174232)
2005
46
Extranodal lymphoplasmacytoid lymphoma (immunocytoma) presenting as small intestinal obstruction. (11300944)
2001
47
Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). (9869067)
1998
48
Megacystis-microcolon-intestinal hypoperistalsis syndrome: a functional intestinal obstruction in the female newborn. (3984525)
1985
49
A case of pneumatosis coli: pneumatosis cystoides intestinalis of the sigmoid colon causing intestinal obstruction, stercoral ulcer and perforation. (5850776)
1965
50
A CASE OF TRANSPLANTED UTERINE FIBROID GIVING RISE TO INTESTINAL OBSTRUCTION. (20760640)
1903

Variations for Intestinal Obstruction

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Expression for genes affiliated with Intestinal Obstruction

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Search GEO for disease gene expression data for Intestinal Obstruction.

Pathways for genes affiliated with Intestinal Obstruction

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Pathways related to Intestinal Obstruction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis36
10.0ACHE, HDC

Compounds for genes affiliated with Intestinal Obstruction

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Compounds related to Intestinal Obstruction according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1bq 302044 2811.3EDN3, EDNRB
2pd 1428934410.3EDN3, EDNRB
3bq6104410.3EDN3, EDNRB
4sarafotoxin4410.3EDNRB, EDN3
5irl 162044 2811.2EDNRB, EDN3
6fr13931744 2811.2EDNRB, EDN3
7tezosentan4410.2EDN3, EDNRB
8polyether sulfone4410.2ALB, MB
9rocuronium44 1111.2ACHE, MB
10bq78844 2811.2EDNRB, EDN3
11ivacaftor50 1111.2ALB, CFTR
12cyclosarin4410.1ACHE, ALB
13bq12344 2811.1EDNRB, EDN3
14glutaraldehyde449.9ALB, ACHE, MB
15salicylic acid44 2810.9CFTR, ALB, MB
16bosentan44 1110.9EDN3, EDNRB
17levodopa44 1110.9HDC, GDNF, EDN3
18histidine449.7MB, MVK, EDN3, HDC
19melatonin44 28 60 24 1113.7GDNF, EDNRB, ESR1
20butyrate449.7CFTR, RET, HDC, CDX2
21norepinephrine44 24 1111.7CFTR, EDN3, MB, GDNF, EDNRB
22pge2449.6EDNRB, EDN3, HDC, CFTR, MB
23dihydrolipoic acid44 1110.6MSRA, MB
24adenylate449.6GDNF, EDNRB, EDN3, CFTR, MB
25cyclic amp44 2410.6GDNF, RET, CFTR, EDN3, HDC
26indomethacin44 28 60 1112.5EDN3, CFTR, ALB, EDNRB
27vitamin d449.4ALB, ESR1, CFTR, CDX2
28acetylcholine44 50 28 24 1113.4MB, ACHE, EDNRB, CFTR, EDN3, GDNF
295-aza-2deoxycytidine449.3EDNRB, ESR1, KRT7, CDX2
30formaldehyde44 2410.3KRT20, KRT7, CFTR, EDN3
31atp44 2810.3EDN3, GUCY2C, MVK, RET, CFTR, GDNF
32vitamin a44 24 1111.2ALB, KRT7, MB, RET
33h2o2449.2GDNF, CFTR, MB, HDC, EDNRB, MSRA
34glutamate449.2GDNF, MB, EDN3, HDC, ACHE, CFTR
35dopamine44 28 24 1112.2EDN3, MB, ACHE, RET, CFTR, GDNF
36doxorubicin44 50 1111.1CFTR, ESR1, KRT20, MB
37iron44 249.9GDNF, KRT7, ALB, KRT20, MB
38progesterone44 28 60 24 1112.7EDN3, CDX2, KRT20, KRT7, ESR1
39aspartate448.7HDC, ALB, EDNRB, EDN3, CFTR, RET
40estrogen448.7ESR1, KRT7, KRT20, CDX2, GDNF, CFTR
41retinoic acid44 249.6GDNF, RET, ESR1, CFTR, EDNRB, HDC
42serine448.6ACHE, NOD2, GDNF, RET, CFTR, EDN3
43alanine448.5EDNRB, MB, ALB, MVK, RET, CFTR
44cysteine448.5CDX2, MSRA, GDNF, EDNRB, CFTR, RET
45paraffin448.1MB, ESR1, GUCY2C, CFTR, RET, KRT7
46vegf448.0KRT20, KRT7, RET, ESR1, EDN3, EDNRB
47testosterone44 60 24 1110.9CFTR, ESR1, RET, ALB, KRT7, MB
48calcium44 50 24 1110.9ALB, EDN3, RET, MSRA, NOD2, CDX2
49lipid447.9GDNF, ALB, KRT7, RET, MVK, MSRA
50tyrosine447.7CD8A, KRT20, CDX2, KRT7, RET, GUCY2C

GO Terms for genes affiliated with Intestinal Obstruction

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Cellular components related to Intestinal Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.3CD8A, ALB, ACHE, APOLD1, EDN3, GDNF

Biological processes related to Intestinal Obstruction according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:001482610.0EDNRB, EDN3
2vasodilationGO:004231110.0EDNRB, CFTR
3posterior midgut developmentGO:000749710.0RET, EDNRB
4melanocyte differentiationGO:00303189.9EDN3, EDNRB
5response to painGO:00482659.9EDNRB, RET
6enteric nervous system developmentGO:00484849.8GDNF, EDNRB, RET
7vasoconstrictionGO:00423109.8EDNRB, EDN3
8neural crest cell migrationGO:00017559.6RET, EDN3, EDNRB, GDNF
9regulation of axonogenesisGO:00507709.5ACHE, RET

Molecular functions related to Intestinal Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1toxic substance bindingGO:00156439.5GUCY2C, ALB
2enzyme bindingGO:00198999.2NOD2, ALB, ESR1, CFTR
3protein bindingGO:00055156.7CFTR, GUCY2C, ESR1, RET, ACHE, ALB

Sources for Intestinal Obstruction

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet