MCID: INT070
MIFTS: 62

Intestinal Obstruction malady

Genetic diseases, Fetal diseases, Gastrointestinal diseases, Rare diseases, Neuronal diseases categories

Summaries for Intestinal Obstruction

About this section


MedlinePlus:33 An intestinal obstruction occurs when food or stool cannot move through the intestines. the obstruction can be complete or partial. there are many causes. the most common are adhesions, hernias, cancers, and certain medicines. symptoms include severe abdominal pain or cramping vomiting bloating loud bowel sounds swelling of the abdomen inability to pass gas constipation a complete intestinal obstruction is a medical emergency. it often requires surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Intestinal Obstruction is related to meconium ileus and pseudomyxoma peritonei. An important gene associated with Intestinal Obstruction is GDNF (glial cell derived neurotrophic factor), and among its related pathways is Biogenic Amine Synthesis. The drugs mineral oil and mineral oil, light and the compounds bq 3020 and pd 142893 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and colon, and related mouse phenotypes are respiratory system and tumorigenesis.

Wikipedia:64 Bowel obstruction (or intestinal obstruction) is a mechanical or functional obstruction of the... more...

Aliases & Classifications for Intestinal Obstruction

About this section

Related Diseases for Intestinal Obstruction

About this section

Diseases in the Intestinal Pseudo-Obstruction family:

intestinal obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 256)
idRelated DiseaseScoreTop Affiliating Genes
1meconium ileus31.5GUCY2C
2pseudomyxoma peritonei30.8KRT7, KRT20, CDX2
3constipation30.7APOLD1, GUCY2C
4mucinous cystadenocarcinoma30.6KRT7, KRT20
5rectal prolapse30.6APOLD1, CFTR
6familial mediterranean fever30.5NOD2, MVK
7cholangiocarcinoma30.4CDX2, KRT20, KRT7
8colorectal cancer30.2GUCY2C, KRT7, KRT20, CDX2
9ovarian cancer30.0EDNRB, EDN3, ESR1, KRT7, MB
10diarrhea30.0CFTR, GUCY2C, APOLD1, ALB
11adenocarcinoma29.8EDNRB, GUCY2C, ESR1, KRT7, KRT20, CDX2
12hirschsprung's disease29.7GDNF, EDNRB, EDN3, RET, ACHE
13melanoma29.6HDC, GDNF, EDNRB, EDN3, CFTR, MB
14breast cancer29.4EDNRB, EDN3, ESR1, KRT7, KRT20, CDX2
15adenoma29.3GDNF, EDNRB, EDN3, GUCY2C, APOLD1, RET
16ileus10.6
17cystic fibrosis10.6
18central hypoventilation syndrome10.6GDNF
19familial medullary thyroid carcinoma10.6GDNF
20peritonitis10.6
21inverted papilloma10.5KRT20
22anuria10.5MB
23meckel's diverticulum10.5
24endometriosis10.5
25intussusception10.4
26signet ring cell adenocarcinoma10.4KRT7, KRT20
27ovarian brenner tumor10.4KRT7, KRT20
28pyoderma gangrenosum10.4MVK, NOD2
29cutaneous paget's disease10.4KRT7, KRT20
30superior mesenteric artery syndrome10.4
31lipoma10.4
32pancreatic ductal carcinoma10.4KRT7, KRT20
33acute poststreptococcal glomerulonephritis10.4EDNRB
34blau syndrome10.4MVK, NOD2
35hepatorenal syndrome10.4ALB
36varicose veins10.4ALB
37wandering spleen10.4
38bladder adenocarcinoma10.4KRT7, KRT20, CDX2
39bronchiolo-alveolar adenocarcinoma10.4KRT7, KRT20, CDX2
40nutritional deficiency disease10.3CFTR, ALB
41ascariasis10.3
42duodenitis10.3
43sarcoma10.3
44barrett's esophagus10.3CDX2, KRT20, KRT7
45renal dysplasia10.3RET, GDNF
46malignant mixed mullerian tumor10.3MB, KRT7
47neuroma10.3RET, GDNF
48gastric adenocarcinoma10.3CDX2, KRT20, KRT7
49anisakiasis10.3
50paralytic ileus10.3

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to intestinal obstruction

Symptoms for Intestinal Obstruction

About this section

Drugs & Therapeutics for Intestinal Obstruction

About this section

Drug clinical trials:

Search ClinicalTrials for Intestinal Obstruction

Search NIH Clinical Center for Intestinal Obstruction

Inferred drug relations via UMLS61/NDF-RT40:

Show with subtypes

Genetic Tests for Intestinal Obstruction

About this section

Anatomical Context for Intestinal Obstruction

About this section

MalaCards organs/tissues related to Intestinal Obstruction:

32
Small intestine, Kidney, Colon, Spleen, Lung, Myeloid, Pancreas, Appendix, Smooth muscle, Breast, Brain, Liver, Thyroid, Prostate, Testis, Monocytes

Animal Models for Intestinal Obstruction or affiliated genes

About this section

Publications for Intestinal Obstruction

About this section

Articles related to Intestinal Obstruction:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Intestinal obstruction due to internal supravesical hernia. (25263273)
2014
2
A patient with hematochezia and intestinal obstruction. (25349601)
2014
3
Gallstone ileus: a rare cause of intestinal obstruction -- case report and literature review. (24157124)
2013
4
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
5
Postoperative Complications Leading to Death after Coagulum Pyelolithotomy in a Tetraplegic Patient: Can We Prevent Prolonged Ileus, Recurrent Intestinal Obstruction due to Adhesions Requiring Laparotomies, Chest Infection Warranting Tracheostomy, and Mechanical Ventilation? (23533931)
2013
6
Distribution of interstitial cells of Cajal in Meriones unguiculatus and alterations in the development of incomplete intestinal obstruction. (23690145)
2013
7
Subacute intestinal obstruction: an enigma revisited. (23550197)
2013
8
Acquired Ileal Atresia Induced by Adhesive Intestinal Obstruction. (24248986)
2013
9
Thymoquinone ameliorates bacterial translocation and inflammatory response in rats with intestinal obstruction. (22750428)
2012
10
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
11
The role of ultrasound in the management of intestinal obstruction. (22416163)
2012
12
Celiac disease presenting with intestinal obstruction: report of two cases. (22965520)
2012
13
Neonatal adrenal hemorrhage presenting as intestinal obstruction. (21992912)
2011
14
Aetiological factors in mechanical intestinal obstruction. (23272428)
2011
15
Severe type of adult jejunal intussusception caused by long intestinal tube in a patient with intestinal obstruction due to cecal carcinoma. (22688937)
2011
16
Presacral parachordoma causing intestinal obstruction in a patient with renal failure: Report of a case. (21922364)
2011
17
Late intestinal obstruction due to an intestinal volvulus in a pregnant patient with a previous Roux-en-Y gastric bypass. (19319613)
2010
18
Intestinal obstruction caused by incarcerated posterolateral right diaphragmatic hernia. (21142393)
2010
19
A rare cause of partial intestinal obstruction in a child: colonic lithobezoar. (21686451)
2009
20
Surgery for the palliation of intestinal obstruction in advanced abdominal malignancy. (20087548)
2009
21
A case of congenital diaphragmatic adult hernia presenting as acute intestinal obstruction. (23133146)
2009
22
Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction. (19206013)
2009
23
Etiological spectrum of acute intestinal obstruction. (20061589)
2009
24
Angiotropic large cell lymphoma presenting as intestinal obstruction. (17628802)
2008
25
Intestinal obstruction in children due to Ascariasis: a tertiary health centre experience. (19858669)
2008
26
Intestinal obstruction in an autistic adolescent. (19240672)
2008
27
Intestinal obstruction from inspissated barium (Barolith): a systematic review of all cases from 1950 to 2006. (18355376)
2008
28
Rapidly fatal clozapine-induced intestinal obstruction without prior warning signs. (19031643)
2008
29
Rare cause of intestinal obstruction after laparoscopic radical nephrectomy: internal herniation via a mesenteric defect. (18597821)
2008
30
Mesh migration following obturator hernia repair presenting as a bezoar inducing small intestinal obstruction. (17375259)
2008
31
Percutaneous endoscopic gastrostomy for gastric decompression after repeated intestinal obstruction after open abdominal surgery. (19098670)
2008
32
Gastric dilation and intestinal obstruction in 76 rabbits. (17890769)
2007
33
Small intestinal obstruction by a Peutz-Jeghers polyp--double-balloon enteroscopic removal. (17614040)
2007
34
A complication of Roux-en-Y gastric bypass: intestinal obstruction. (17891439)
2007
35
Segmental defect of intestinal musculature: a rare cause of intestinal obstruction in children. (16899190)
2006
36
Neonatal intestinal obstruction simulating meconium ileus in infants with long-segment intestinal aganglionosis: radiographic findings that prompt the need for rectal biopsy. (16341713)
2006
37
Acute small intestinal obstruction associated with Parascaris equorum infection in young horses: 25 cases (1985-2004). (17151735)
2006
38
Gestational intestinal obstruction: a case report and review of literature. (16408180)
2006
39
An unusual cause of subacute intestinal obstruction. (16531532)
2006
40
Chronic intestinal obstruction due to rectosigmoid endometriosis: a case report. (16805176)
2006
41
Intestinal obstruction due to rectal endometriosis. (16358167)
2005
42
Management and prognosis of colon cancer in patients with intestinal obstruction or peritonitis: a French population-based study. (15917717)
2005
43
Spectrum of causes of intestinal obstruction in adult Nigerian patients. (16035380)
2005
44
Palliative care for intestinal obstruction in recurrent ovarian cancer: a multivariate analysis. (16174232)
2005
45
Extranodal lymphoplasmacytoid lymphoma (immunocytoma) presenting as small intestinal obstruction. (11300944)
2001
46
Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). (9869067)
1998
47
Secondary effects of prolonged intestinal obstruction on the enteric nervous system in the rat. (7905922)
1993
48
Megacystis-microcolon-intestinal hypoperistalsis syndrome: a functional intestinal obstruction in the female newborn. (3984525)
1985
49
A case of pneumatosis coli: pneumatosis cystoides intestinalis of the sigmoid colon causing intestinal obstruction, stercoral ulcer and perforation. (5850776)
1965
50
A CASE OF TRANSPLANTED UTERINE FIBROID GIVING RISE TO INTESTINAL OBSTRUCTION. (20760640)
1903

Variations for Intestinal Obstruction

About this section

Expression for genes affiliated with Intestinal Obstruction

About this section
Expression patterns in normal tissues for genes affiliated with Intestinal Obstruction

Search GEO for disease gene expression data for Intestinal Obstruction.

Pathways for genes affiliated with Intestinal Obstruction

About this section

Pathways related to Intestinal Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis37
10.0ACHE, HDC

Compounds for genes affiliated with Intestinal Obstruction

About this section

Compounds related to Intestinal Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1bq 302044 2911.3EDN3, EDNRB
2pd 1428934410.3EDN3, EDNRB
3bq6104410.3EDN3, EDNRB
4sarafotoxin4410.3EDNRB, EDN3
5irl 162044 2911.2EDNRB, EDN3
6fr13931744 2911.2EDNRB, EDN3
7tezosentan4410.2EDN3, EDNRB
8polyether sulfone4410.2ALB, MB
9rocuronium44 1211.2ACHE, MB
10bq78844 2911.2EDNRB, EDN3
11ivacaftor50 1211.2ALB, CFTR
12cyclosarin4410.1ACHE, ALB
13bq12344 2911.1EDNRB, EDN3
14glutaraldehyde449.9ALB, ACHE, MB
15salicylic acid44 2910.9CFTR, ALB, MB
16bosentan44 1210.9EDN3, EDNRB
17levodopa44 1210.9HDC, GDNF, EDN3
18histidine449.7MB, MVK, EDN3, HDC
19melatonin44 29 60 25 1213.7GDNF, EDNRB, ESR1
20butyrate449.7CFTR, RET, HDC, CDX2
21norepinephrine44 25 1211.7CFTR, EDN3, MB, GDNF, EDNRB
22pge2449.6EDNRB, EDN3, HDC, CFTR, MB
23dihydrolipoic acid44 1210.6MSRA, MB
24adenylate449.6GDNF, EDNRB, EDN3, CFTR, MB
25cyclic amp44 2510.6GDNF, RET, CFTR, EDN3, HDC
26indomethacin44 29 60 1212.5EDN3, CFTR, ALB, EDNRB
27vitamin d449.4ALB, ESR1, CFTR, CDX2
28acetylcholine44 50 29 25 1213.4MB, ACHE, EDNRB, CFTR, EDN3, GDNF
295-aza-2deoxycytidine449.3EDNRB, ESR1, KRT7, CDX2
30formaldehyde44 2510.3KRT20, KRT7, CFTR, EDN3
31atp44 2910.3EDN3, GUCY2C, MVK, RET, CFTR, GDNF
32vitamin a44 25 1211.2ALB, KRT7, MB, RET
33h2o2449.2GDNF, CFTR, MB, HDC, EDNRB, MSRA
34glutamate449.2GDNF, MB, EDN3, HDC, ACHE, CFTR
35dopamine44 29 25 1212.2EDN3, MB, ACHE, RET, CFTR, GDNF
36doxorubicin44 50 1211.1CFTR, ESR1, KRT20, MB
37iron44 259.9GDNF, KRT7, ALB, KRT20, MB
38progesterone44 29 60 25 1212.7EDN3, CDX2, KRT20, KRT7, ESR1
39aspartate448.7HDC, ALB, EDNRB, EDN3, CFTR, RET
40estrogen448.7ESR1, KRT7, KRT20, CDX2, GDNF, CFTR
41retinoic acid44 259.6GDNF, RET, ESR1, CFTR, EDNRB, HDC
42serine448.6ACHE, NOD2, GDNF, RET, CFTR, EDN3
43alanine448.5EDNRB, MB, ALB, MVK, RET, CFTR
44cysteine448.5CDX2, MSRA, GDNF, EDNRB, CFTR, RET
45paraffin448.1MB, ESR1, GUCY2C, CFTR, RET, KRT7
46vegf448.0KRT20, KRT7, RET, ESR1, EDN3, EDNRB
47testosterone44 60 25 1210.9CFTR, ESR1, RET, ALB, KRT7, MB
48calcium44 50 25 1210.9ALB, EDN3, RET, MSRA, NOD2, CDX2
49lipid447.9GDNF, ALB, KRT7, RET, MVK, MSRA
50tyrosine447.7CD8A, KRT20, CDX2, KRT7, RET, GUCY2C

GO Terms for genes affiliated with Intestinal Obstruction

About this section

Cellular components related to Intestinal Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.3CD8A, ALB, ACHE, APOLD1, EDN3, GDNF

Biological processes related to Intestinal Obstruction according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:01482610.0EDNRB, EDN3
2vasodilationGO:04231110.0EDNRB, CFTR
3posterior midgut developmentGO:00749710.0RET, EDNRB
4melanocyte differentiationGO:0303189.9EDN3, EDNRB
5response to painGO:0482659.9EDNRB, RET
6enteric nervous system developmentGO:0484849.8GDNF, EDNRB, RET
7vasoconstrictionGO:0423109.8EDNRB, EDN3
8neural crest cell migrationGO:0017559.6RET, EDN3, EDNRB, GDNF
9regulation of axonogenesisGO:0507709.5ACHE, RET

Molecular functions related to Intestinal Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1toxic substance bindingGO:0156439.5GUCY2C, ALB
2enzyme bindingGO:0198999.2NOD2, ALB, ESR1, CFTR
3protein bindingGO:0055156.7CFTR, GUCY2C, ESR1, RET, ACHE, ALB

Products for genes affiliated with Intestinal Obstruction

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Intestinal Obstruction

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet