MCID: INT070
MIFTS: 63

Intestinal Obstruction malady

Genetic diseases, Fetal diseases, Gastrointestinal diseases, Rare diseases, Neuronal diseases categories

Summaries for Intestinal Obstruction

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 An intestinal obstruction occurs when food or stool cannot move through the intestines. the obstruction can be complete or partial. there are many causes. the most common are adhesions, hernias, cancers, and certain medicines. symptoms include severe abdominal pain or cramping vomiting bloating loud bowel sounds swelling of the abdomen inability to pass gas constipation a complete intestinal obstruction is a medical emergency. it often requires surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Intestinal Obstruction is related to meconium ileus and pseudomyxoma peritonei. An important gene associated with Intestinal Obstruction is GDNF (glial cell derived neurotrophic factor), and among its related pathways is Biogenic Amine Synthesis. The drugs mineral oil and mineral oil, light and the compounds bq610 and pd 142893 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and colon, and related mouse phenotypes are respiratory system and tumorigenesis.

Wikipedia:66 Bowel obstruction (or intestinal obstruction) is a mechanical or functional obstruction of the... more...

Aliases & Classifications for Intestinal Obstruction

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
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Related Diseases for Intestinal Obstruction

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Intestinal Pseudo-Obstruction family:

intestinal obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1meconium ileus30.9GUCY2C
2pseudomyxoma peritonei30.4KRT7, KRT20, CDX2
3constipation30.4APOLD1, GUCY2C
4ovarian cancer30.3EDNRB, EDN3, ESR1, KRT7, MB
5mucinous cystadenocarcinoma30.1KRT7, KRT20
6rectal prolapse30.1APOLD1, CFTR
7familial mediterranean fever30.0NOD2, MVK
8cholangiocarcinoma30.0CDX2, KRT20, KRT7
9colon cancer30.0CFTR, GUCY2C, KRT20, CDX2
10colorectal cancer30.0GUCY2C, KRT7, KRT20, CDX2
11diarrhea29.9CFTR, GUCY2C, APOLD1, ALB
12adenoma29.9GDNF, EDNRB, EDN3, GUCY2C, APOLD1, RET
13hirschsprung's disease29.9GDNF, EDNRB, EDN3, RET, ACHE
14melanoma29.8HDC, GDNF, EDNRB, EDN3, CFTR, MB
15breast cancer29.8EDNRB, EDN3, ESR1, KRT7, KRT20, CDX2
16adenocarcinoma29.8EDNRB, GUCY2C, ESR1, KRT7, KRT20, CDX2
17ileus10.6
18cystic fibrosis10.6
19peritonitis10.5
20meckel's diverticulum10.5
21endometriosis10.4
22intussusception10.4
23superior mesenteric artery syndrome10.4
24lipoma10.4
25duodenitis10.3
26sarcoma10.3
27wandering spleen10.3
28ascariasis10.3
29paralytic ileus10.3
30anisakiasis10.2
31megacystis microcolon intestinal hypoperistalsis syndrome10.2
32teratoma10.2
33malignant peritoneal mesothelioma10.2
34peritoneal mesothelioma10.2
35gastrointestinal stromal tumor10.2
36appendicitis10.2
37tuberculosis10.2
38central hypoventilation syndrome10.1GDNF
39familial medullary thyroid carcinoma10.1GDNF
40inverted papilloma10.1KRT20
41anuria10.1MB
42signet ring cell adenocarcinoma10.1KRT7, KRT20
43ovarian brenner tumor10.1KRT7, KRT20
44pyoderma gangrenosum10.1MVK, NOD2
45cutaneous paget's disease10.1KRT7, KRT20
46burns10.1
47crohn's disease10.1
48enterocele10.1
49eosinophilic gastroenteritis10.1
50intestinal volvulus10.1

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to intestinal obstruction

Symptoms for Intestinal Obstruction

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Drugs & Therapeutics for Intestinal Obstruction

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Intestinal Obstruction

Drug clinical trials:

Search ClinicalTrials for Intestinal Obstruction

Search NIH Clinical Center for Intestinal Obstruction

Search CenterWatch for Intestinal Obstruction

Inferred drug relations via UMLS63/NDF-RT42:

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Genetic Tests for Intestinal Obstruction

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Anatomical Context for Intestinal Obstruction

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Sources:
34MalaCards
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MalaCards organs/tissues related to Intestinal Obstruction:

34
Small intestine, Kidney, Colon, Spleen, Lung, Myeloid, Pancreas, Appendix, Smooth muscle, Breast, Liver, Thyroid, Prostate, Testis, Brain, Monocytes

Animal Models for Intestinal Obstruction or affiliated genes

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38MGI
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Publications for Intestinal Obstruction

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53PubMed
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Articles related to Intestinal Obstruction:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Gallstone ileus: a rare cause of intestinal obstruction -- case report and literature review. (24157124)
2013
2
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
3
Postoperative Complications Leading to Death after Coagulum Pyelolithotomy in a Tetraplegic Patient: Can We Prevent Prolonged Ileus, Recurrent Intestinal Obstruction due to Adhesions Requiring Laparotomies, Chest Infection Warranting Tracheostomy, and Mechanical Ventilation? (23533931)
2013
4
Distribution of interstitial cells of Cajal in Meriones unguiculatus and alterations in the development of incomplete intestinal obstruction. (23690145)
2013
5
Subacute intestinal obstruction: an enigma revisited. (23550197)
2013
6
Acquired Ileal Atresia Induced by Adhesive Intestinal Obstruction. (24248986)
2013
7
Experimental study of the diagnostic potentialities of bioimpedance measurement in acute intestinal obstruction. (24288772)
2013
8
Cecal Duplication Cyst Presenting as a Recurrent Intestinal Obstruction. (24363011)
2013
9
Thymoquinone ameliorates bacterial translocation and inflammatory response in rats with intestinal obstruction. (22750428)
2012
10
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
11
The role of ultrasound in the management of intestinal obstruction. (22416163)
2012
12
Neonatal adrenal hemorrhage presenting as intestinal obstruction. (21992912)
2011
13
Aetiological factors in mechanical intestinal obstruction. (23272428)
2011
14
Severe type of adult jejunal intussusception caused by long intestinal tube in a patient with intestinal obstruction due to cecal carcinoma. (22688937)
2011
15
Presacral parachordoma causing intestinal obstruction in a patient with renal failure: Report of a case. (21922364)
2011
16
Late intestinal obstruction due to an intestinal volvulus in a pregnant patient with a previous Roux-en-Y gastric bypass. (19319613)
2010
17
Intestinal obstruction caused by incarcerated posterolateral right diaphragmatic hernia. (21142393)
2010
18
A rare cause of partial intestinal obstruction in a child: colonic lithobezoar. (21686451)
2009
19
Surgery for the palliation of intestinal obstruction in advanced abdominal malignancy. (20087548)
2009
20
A case of congenital diaphragmatic adult hernia presenting as acute intestinal obstruction. (23133146)
2009
21
Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction. (19206013)
2009
22
Etiological spectrum of acute intestinal obstruction. (20061589)
2009
23
Angiotropic large cell lymphoma presenting as intestinal obstruction. (17628802)
2008
24
Intestinal obstruction in children due to Ascariasis: a tertiary health centre experience. (19858669)
2008
25
Intestinal obstruction in an autistic adolescent. (19240672)
2008
26
Intestinal obstruction from inspissated barium (Barolith): a systematic review of all cases from 1950 to 2006. (18355376)
2008
27
Rapidly fatal clozapine-induced intestinal obstruction without prior warning signs. (19031643)
2008
28
Rare cause of intestinal obstruction after laparoscopic radical nephrectomy: internal herniation via a mesenteric defect. (18597821)
2008
29
Mesh migration following obturator hernia repair presenting as a bezoar inducing small intestinal obstruction. (17375259)
2008
30
Percutaneous endoscopic gastrostomy for gastric decompression after repeated intestinal obstruction after open abdominal surgery. (19098670)
2008
31
Gastric dilation and intestinal obstruction in 76 rabbits. (17890769)
2007
32
Small intestinal obstruction by a Peutz-Jeghers polyp--double-balloon enteroscopic removal. (17614040)
2007
33
A complication of Roux-en-Y gastric bypass: intestinal obstruction. (17891439)
2007
34
Segmental defect of intestinal musculature: a rare cause of intestinal obstruction in children. (16899190)
2006
35
Neonatal intestinal obstruction simulating meconium ileus in infants with long-segment intestinal aganglionosis: radiographic findings that prompt the need for rectal biopsy. (16341713)
2006
36
Acute small intestinal obstruction associated with Parascaris equorum infection in young horses: 25 cases (1985-2004). (17151735)
2006
37
Gestational intestinal obstruction: a case report and review of literature. (16408180)
2006
38
An unusual cause of subacute intestinal obstruction. (16531532)
2006
39
Chronic intestinal obstruction due to rectosigmoid endometriosis: a case report. (16805176)
2006
40
Intestinal obstruction due to rectal endometriosis. (16358167)
2005
41
Management and prognosis of colon cancer in patients with intestinal obstruction or peritonitis: a French population-based study. (15917717)
2005
42
Spectrum of causes of intestinal obstruction in adult Nigerian patients. (16035380)
2005
43
Palliative care for intestinal obstruction in recurrent ovarian cancer: a multivariate analysis. (16174232)
2005
44
Ultrasonography diagnosis of occult obturator hernia presenting as intestinal obstruction in ED. (15765363)
2005
45
Extranodal lymphoplasmacytoid lymphoma (immunocytoma) presenting as small intestinal obstruction. (11300944)
2001
46
Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). (9869067)
1998
47
Secondary effects of prolonged intestinal obstruction on the enteric nervous system in the rat. (7905922)
1993
48
Megacystis-microcolon-intestinal hypoperistalsis syndrome: a functional intestinal obstruction in the female newborn. (3984525)
1985
49
A case of pneumatosis coli: pneumatosis cystoides intestinalis of the sigmoid colon causing intestinal obstruction, stercoral ulcer and perforation. (5850776)
1965
50
A CASE OF TRANSPLANTED UTERINE FIBROID GIVING RISE TO INTESTINAL OBSTRUCTION. (20760640)
1903

Variations for Intestinal Obstruction

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Expression for genes affiliated with Intestinal Obstruction

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Obstruction

Search GEO for disease gene expression data for Intestinal Obstruction.

Pathways for genes affiliated with Intestinal Obstruction

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Intestinal Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis39
10.0ACHE, HDC

Compounds for genes affiliated with Intestinal Obstruction

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Intestinal Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1bq6104610.3EDNRB, EDN3
2pd 1428934610.3EDNRB, EDN3
3bq 302046 3011.3EDNRB, EDN3
4irl 162046 3011.3EDNRB, EDN3
5fr13931746 3011.2EDNRB, EDN3
6sarafotoxin4610.2EDNRB, EDN3
7tezosentan4610.2EDNRB, EDN3
8polyether sulfone4610.2MB, ALB
9rocuronium46 1211.2MB, ACHE
10bq78846 3011.2EDNRB, EDN3
11ivacaftor52 1211.2CFTR, ALB
12cyclosarin4610.1ACHE, ALB
13bq12346 3011.1EDN3, EDNRB
14glutaraldehyde469.9MB, ALB, ACHE
15salicylic acid46 3010.9CFTR, ALB, MB
16levodopa46 1210.9EDN3, GDNF, HDC
17bosentan46 1210.8EDNRB, EDN3
18histidine469.7HDC, EDN3, MVK, MB
19melatonin46 30 62 25 1213.7GDNF, EDNRB, ESR1
20butyrate469.7HDC, CFTR, RET, CDX2
21dihydrolipoic acid46 1210.7MSRA, MB
22norepinephrine46 25 1211.7GDNF, EDNRB, EDN3, CFTR, MB
23pge2469.6HDC, EDNRB, EDN3, CFTR, MB
24adenylate469.6GDNF, EDNRB, EDN3, CFTR, MB
25cyclic amp46 2510.6HDC, GDNF, EDN3, CFTR, RET
26indomethacin46 30 62 1212.5ALB, CFTR, EDN3, EDNRB
27vitamin d469.4CDX2, ALB, ESR1, CFTR
28acetylcholine46 52 30 25 1213.4GDNF, EDNRB, EDN3, CFTR, ACHE, MB
295-aza-2deoxycytidine469.3EDNRB, ESR1, KRT7, CDX2
30formaldehyde46 2510.3EDN3, CFTR, KRT7, KRT20
31atp46 3010.3GDNF, EDN3, CFTR, GUCY2C, RET, MVK
32vitamin a46 25 1211.2RET, ALB, KRT7, MB
33h2o2469.2HDC, GDNF, EDNRB, CFTR, MSRA, MB
34glutamate469.2HDC, GDNF, EDNRB, EDN3, CFTR, ACHE
35dopamine46 30 25 1212.2HDC, GDNF, EDN3, CFTR, RET, ACHE
36doxorubicin46 52 1211.1MB, KRT20, ESR1, CFTR
37iron46 259.9GDNF, ALB, KRT7, KRT20, MB
38progesterone46 30 62 25 1212.7EDN3, ESR1, KRT7, KRT20, CDX2
39aspartate468.7HDC, GDNF, EDNRB, EDN3, CFTR, RET
40estrogen468.7GDNF, CFTR, ESR1, KRT7, KRT20, CDX2
41retinoic acid46 259.6HDC, GDNF, EDNRB, CFTR, ESR1, RET
42serine468.6GDNF, EDNRB, EDN3, CFTR, RET, MVK
43alanine468.5HDC, GDNF, EDNRB, EDN3, CFTR, RET
44cysteine468.5GDNF, EDNRB, CFTR, RET, MSRA, ALB
45paraffin468.1CDX2, CFTR, GUCY2C, ESR1, RET, KRT7
46vegf468.0GDNF, EDNRB, EDN3, ESR1, RET, KRT7
47testosterone46 62 25 1210.9EDN3, CFTR, ESR1, RET, ALB, KRT7
48calcium46 52 25 1210.9HDC, GDNF, EDNRB, EDN3, GUCY2C, RET
49lipid467.9GDNF, RET, MSRA, MVK, ALB, KRT7
50tyrosine467.7HDC, GDNF, EDNRB, EDN3, GUCY2C, RET

GO Terms for genes affiliated with Intestinal Obstruction

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17Gene Ontology
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Cellular components related to Intestinal Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.3CD8A, ALB, ACHE, APOLD1, EDN3, GDNF

Biological processes related to Intestinal Obstruction according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:01482610.0EDNRB, EDN3
2vasodilationGO:04231110.0EDNRB, CFTR
3posterior midgut developmentGO:00749710.0RET, EDNRB
4melanocyte differentiationGO:0303189.9EDN3, EDNRB
5response to painGO:0482659.9EDNRB, RET
6enteric nervous system developmentGO:0484849.8GDNF, EDNRB, RET
7vasoconstrictionGO:0423109.8EDNRB, EDN3
8neural crest cell migrationGO:0017559.6RET, EDN3, EDNRB, GDNF
9regulation of axonogenesisGO:0507709.5ACHE, RET

Molecular functions related to Intestinal Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1toxic substance bindingGO:0156439.5GUCY2C, ALB
2enzyme bindingGO:0198999.2CFTR, ESR1, ALB, NOD2
3protein bindingGO:0055156.7EDNRB, CFTR, GUCY2C, ESR1, RET, ACHE

Products for genes affiliated with Intestinal Obstruction

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  • Antibodies
  • Proteins
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Sources for Intestinal Obstruction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet