MCID: INT070
MIFTS: 54

Intestinal Obstruction malady

Fetal diseases, Gastrointestinal diseases categories

Summaries for Intestinal Obstruction

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 An intestinal obstruction occurs when food or stool cannot move through the intestines. the obstruction can be complete or partial. there are many causes. the most common are adhesions, hernias, cancers, and certain medicines. symptoms include severe abdominal pain or cramping vomiting bloating loud bowel sounds swelling of the abdomen inability to pass gas constipation a complete intestinal obstruction is a medical emergency. it often requires surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Intestinal Obstruction is related to cystic fibrosis and peritonitis. An important gene associated with Intestinal Obstruction is GDNF (glial cell derived neurotrophic factor). The drugs mineral oil and mineral oil, light and the compounds cftrinh 172 and dcpib have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and kidney, and related mouse phenotypes are growth/size and digestive/alimentary.

Wikipedia:63 Bowel obstruction (or intestinal obstruction) is a mechanical or functional obstruction of the... more...

Aliases & Classifications for Intestinal Obstruction

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Intestinal Obstruction

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17GeneCards, 18GeneDecks
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Diseases in the Intestinal Pseudo-Obstruction family:

intestinal obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis30.8CFTR, GUCY2C
2peritonitis30.7MB
3ovarian cancer30.4EDN3, KRT7, MB
4constipation30.2GUCY2C, APOLD1
5pseudomyxoma peritonei30.2CDX2, KRT7, KRT20
6colon cancer30.0CFTR, CDX2, GUCY2C, KRT20
7adenoma30.0KRT20, EDN3, CDX2, GUCY2C, APOLD1, GDNF
8pancreatitis29.8CFTR
9esophagitis29.8CDX2
10colon adenocarcinoma29.8KRT20
11ulcerative colitis29.8NOD2
12lung cancer29.8KRT7
13rectal prolapse29.8APOLD1, CFTR
14mucinous cystadenocarcinoma29.8KRT7, KRT20
15diarrhea29.8CFTR, APOLD1, GUCY2C
16hirschsprung's disease29.8GDNF, SOX10, EDN3, NRTN
17adenocarcinoma29.8GUCY2C, CDX2, KRT20, KRT7
18colorectal cancer29.8KRT20, KRT7, GUCY2C, CDX2
19breast cancer29.8NOD2, CDX2, KRT7, HDC, EDN3, CFTR
20melanoma29.8SOX10, EDN3, FLNA, HDC, CDX2, CD8A
21meckel's diverticulum10.5
22intestinal volvulus10.5
23endometriosis10.4
24intussusception10.4
25lipoma10.4
26superior mesenteric artery syndrome10.4
27intestinal perforation10.4
28ascariasis10.3
29duodenitis10.3
30duodenal obstruction10.3
31intestinal disease10.3
32sarcoma10.3
33paralytic ileus10.3
34meconium ileus10.3
35endometriosis of intestine10.2
36intestinal atresia10.2
37malignant peritoneal mesothelioma10.1
38anisakiasis10.1
39gastrointestinal stromal tumor10.1
40appendicitis10.1
41adult syndrome10.1
42intestinal tuberculosis10.1
43congenital diaphragmatic hernia10.1
44small intestinal sarcoma10.1
45small intestine cancer10.1
46tuberculosis10.1
47burns10.1
48crohn's disease10.1
49enterocele10.1
50acute myeloid leukemia10.1

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to intestinal obstruction

Clinical Features for Intestinal Obstruction

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Drugs & Therapeutics for Intestinal Obstruction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Intestinal Obstruction

Search CenterWatch for Intestinal Obstruction

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Intestinal Obstruction

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Anatomical Context for Intestinal Obstruction

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32MalaCards
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MalaCards organs/tissues related to Intestinal Obstruction:

32
Small intestine, Colon, Kidney, Smooth muscle, Lung, Spleen, Liver, Appendix, Myeloid, Pancreas, Breast, Thyroid, Uterus, Prostate, Testis, Brain, Monocytes, Lymph node

Animal Models for Intestinal Obstruction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intestinal Obstruction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.8MB, GUCY2C, FLNA, HDC, CDX2, GDNF
2MP:00053818.5NOD2, SOX10, GUCY2C, EDN3, FLNA, NRTN

Publications for Intestinal Obstruction

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50PubMed
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Articles related to Intestinal Obstruction:

(show top 50)    (show all 1068)
idTitleAuthorsYear
1
Adult paratesticular rhabdomyosarcoma presenting as acute intestinal obstruction-a case report. (24426543)
2013
2
Enterovesical fistula and intestinal obstruction by ileal endometriosis. (24274454)
2013
3
Colonic lithobezoar: a rare cause of partial intestinal obstruction. (23692843)
2013
4
Re: adhesive intestinal obstruction in laparoscopic vs open colorectal resection. (23586639)
2013
5
Possible antistenotic effect of tranilast in a patient with small bowel tuberculosis to prevent intestinal obstruction due to stenosis progression by antituberculous chemotherapy. (23363021)
2013
6
Intestinal obstruction and pseudo-obstruction in patients with systemic sclerosis. (24303689)
2013
7
Obstructed hemivagina and ipsilateral renal agenesis with intestinal malrotation. (23910815)
2013
8
Hemophagocytic lymphohistiocytosis with multiorgan involvement in children with chronic intestinal pseudo-obstruction receiving parenteral nutrition support. (21866056)
2012
9
A patient with biliary colic and intestinal obstruction. (21193442)
2012
10
Endoscopic-assisted colopexy and push percutaneous colostomy in the transverse colon for refractory chronic intestinal pseudo-obstruction. (22146183)
2011
11
Attraction of magnetic foreign bodies leading to intestinal obstruction and gastro-colon-jejunum fistula. (22182902)
2011
12
Phytobezoar as a cause of intestinal obstruction. (21826548)
2011
13
Contraceptive ring-induced intestinal obstruction. (22198944)
2011
14
Bowel obstruction caused by intestinal tuberculosis: an update. (22673714)
2011
15
Intestinal obstruction due to Basidiobolus ranarum: an unusual case. (21654119)
2011
16
Stone vomiting and intestinal obstruction in a patient with gallstones. (21375818)
2010
17
Delay in diagnosis of intestinal obstruction in a patient with familial mediterranean Fever. (21769256)
2010
18
Effect of Obstructive Jaundice and Nitric Oxide on the Profiles of Intestinal Bacterial Flora in Wild and iNOS Mice. (19308270)
2009
19
Identifying intestinal obstruction: Better safe than sorry. (19920757)
2009
20
A case report of intestinal obstruction due to phytobezoar within Meckel's diverticulum. (19330743)
2009
21
Deficient alpha-smooth muscle actin as a cause of functional intestinal obstruction in childhood. (18726604)
2008
22
Obstructive jaundice promotes intestinal-barrier dysfunction and bacterial translocation: experimental study. (19669340)
2007
23
Lipoma within inverted Meckel's diverticulum as a cause of recurrent partial intestinal obstruction and hemorrhage: a case report and review of literature. (17373755)
2007
24
Gallstone ileus: a forgotten rare cause of intestinal obstruction. (19858612)
2007
25
Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction. (16329126)
2006
26
Chronic intestinal obstruction due to rectosigmoid endometriosis: a case report. (16805176)
2006
27
Intestinal pseudo-obstruction in acute myelitis. (16467605)
2006
28
Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice. (16804311)
2006
29
Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. (17030173)
2006
30
Ultrasonography diagnosis of occult obturator hernia presenting as intestinal obstruction in ED. (15765363)
2005
31
Neostigmine for the treatment of acute hepatic encephalopathy with acute intestinal pseudo-obstruction in a cirrhotic patient. (15716622)
2005
32
Intestinal transplantation for total/near-total aganglionosis and intestinal pseudo-obstruction. (15660322)
2004
33
Prenatal diagnosis of non-obstructive megacystis as part of the megacystis-microcolon-intestinal hypoperistalsis syndrome with favourable postnatal outcome. (11536277)
2001
34
Familial mitochondrial intestinal pseudo-obstruction and neurogenic bladder. (10868781)
2000
35
Intestinal pseudo-obstruction following renal stone extracorporeal lithotripsy in a diabetic patient. (10692529)
2000
36
Chronic intestinal pseudo-obstruction: pediatric case presentations and review of the literature. (11098449)
2000
37
Chronic intestinal pseudo-obstruction: treatment and long term follow up of 44 patients. (10373127)
1999
38
Chronic intestinal pseudo-obstruction/Neuronal dysplasia. (10541964)
1999
39
Autonomic dysfunction in chronic intestinal pseudo-obstruction. (9869551)
1998
40
Pancreatic somatostatinoma presenting with chronic intestinal pseudo-obstruction syndrome. (17912215)
1996
41
Acute and chronic intestinal pseudo-obstruction. (2024582)
1991
42
Chronic intestinal pseudo-obstruction syndrome in pediatrics. Results of a national survey by members of the North American Society of Pediatric Gastroenterology and Nutrition. (3290417)
1988
43
Case of the month No. 65. Duodenal obstruction secondary to intestinal malrotation. (6870569)
1983
44
Chronic intestinal pseudo-obstruction. (6951328)
1982
45
Total intestinal aganglionosis presenting as duodenal obstruction. (5129190)
1971
46
Intestinal pseudo-obstruction in systemic amyloidosis. (5473607)
1970
47
Intestinal pseudo-obstruction. (5945656)
1966
48
A case of pneumatosis coli: pneumatosis cystoides intestinalis of the sigmoid colon causing intestinal obstruction, stercoral ulcer and perforation. (5850776)
1965
49
Acute intestinal obstruction with volvulus in akinetic mutism. A report of a case. (13978430)
1963
50
Intestinal tuberculosis with stenosis and obstruction. (14913704)
1952

Genetic Variations for Intestinal Obstruction

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Expression for genes affiliated with Intestinal Obstruction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Obstruction

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Pathways for genes affiliated with Intestinal Obstruction

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Compounds for genes affiliated with Intestinal Obstruction

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59Tocris Bioscience, 44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Intestinal Obstruction according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1cftrinh 1725910.4CFTR, CLCA3P
2dcpib5910.4CFTR, CLCA3P
3chromanol 293b44 59 2812.3CLCA3P, CFTR
4lonidamine44 5911.3CLCA3P, CFTR
5carnosine44 2411.2MB, HDC
6levodopa44 1111.1GDNF, HDC, EDN3
7histidine449.9HDC, EDN3, MB, MVK
8acetylcholine44 49 28 11 2413.9MB, EDN3, NRTN, GDNF, CFTR
9mucicarmine449.8KRT20, KRT7
10aspartate449.8MB, EDN3, HDC, GDNF, CFTR
11nppb44 59 2811.8CFTR, CLCA3P
12formaldehyde44 2410.8EDN3, CFTR, KRT7, KRT20
13norepinephrine44 11 2411.8MB, EDN3, GDNF, CFTR
14glutamate449.7CFTR, GDNF, NRTN, HDC, EDN3, MB
15dopamine44 28 11 2412.5CFTR, MB, EDN3, FLNA, HDC, NRTN
16alanine449.5MVK, MB, EDN3, FLNA, HDC, GDNF
17paraffin449.4MB, GUCY2C, CDX2, CFTR, KRT7, KRT20
18testosterone44 59 11 2412.4KRT20, KRT7, CFTR, EDN3, MB
19serine449.1MVK, MB, EDN3, FLNA, GDNF, CFTR
20tyrosine448.7GUCY2C, EDN3, FLNA, HDC, NRTN, CDX2

GO Terms for genes affiliated with Intestinal Obstruction

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16Gene Ontology
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Biological processes related to Intestinal Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enteric nervous system developmentGO:04848410.1GDNF, SOX10
2neural crest cell migrationGO:0017559.5GDNF, NRTN, EDN3, SOX10

Products for genes affiliated with Intestinal Obstruction

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Sources for Intestinal Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet