MCID: INT071
MIFTS: 42

Intestinal Perforation malady

Gastrointestinal diseases category
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Summaries for Intestinal Perforation

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Wikipedia:65 Gastrointestinal perforation is a complete penetration of any part of the wall of the gastrointestinal... more...

MalaCards based summary: Intestinal Perforation, also known as perforation of intestine, is related to melanoma and peritonitis. An important gene associated with Intestinal Perforation is PTS (6-pyruvoyltetrahydropterin synthase). The compounds pteridine and sepiapterin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, bone and colon, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Intestinal Perforation

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Intestinal Perforation, Aliases & Descriptions:

Name: Intestinal Perforation 8 10 62
 
Perforation of Intestine 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:2074
NCIt39 C39611
MeSH34 D007416
SNOMED-CT57 56905009
ICD9CM27 569.83
ICD1025 K63.1

Related Diseases for Intestinal Perforation

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Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma29.3PTS, CEACAM3, NKX2-1, NOS1
2peritonitis10.8
3typhoid fever10.6
4wegener's granulomatosis10.5
5tuberculosis10.4
6purpura10.4
7perinatal intestinal perforation10.3
8polyarteritis nodosa10.3
9miliary tuberculosis10.3
10cytomegalovirus infection10.3
11sepsis10.3
12behcet's disease10.2
13crohn's disease10.2
14patent ductus arteriosus10.2
15temporal arteritis10.2
16scleroderma10.2
17degos disease10.2
18arthritis10.2
19hodgkin's lymphoma10.2
20rheumatoid arthritis10.2
21pleomorphic carcinoma10.2
22intussusception10.2
23churg-strauss syndrome10.2
24candidiasis10.2
25ehlers-danlos syndrome10.2
26vaginitis10.2
27granulomatosis with polyangiitis10.2
28eosinophilic granulomatosis with polyangiitis10.2
29thymus cancer10.1NKX2-1, CEACAM3
30malignant pleural mesothelioma10.1NKX2-1, CEACAM3
31large cell carcinoma10.1CEACAM3, NKX2-1
32thyroid medullary carcinoma10.1NKX2-1, CEACAM3
33thymoma10.1CEACAM3, NKX2-1
34hyperphenylalaninemia10.0PTS, NOS1
35malignant mesothelioma10.0NKX2-1, CEACAM3
36neuroendocrine tumor10.0CEACAM3, NKX2-1
37acute lymphoblastic leukemia10.0
38ankylosing spondylitis10.0
39autoimmune hepatitis10.0
40burkitt's lymphoma10.0
41burns10.0
42cerebral hemorrhage10.0
43cervical cancer10.0
44colorectal cancer10.0
45gas gangrene10.0
46glomerulonephritis10.0
47hematopoietic stem cell transplantation10.0
48hepatitis10.0
49hypertension10.0
50leukemia10.0

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to intestinal perforation

Symptoms for Intestinal Perforation

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Drugs & Therapeutics for Intestinal Perforation

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Drug clinical trials:

Search ClinicalTrials for Intestinal Perforation

Search NIH Clinical Center for Intestinal Perforation

Genetic Tests for Intestinal Perforation

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Anatomical Context for Intestinal Perforation

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MalaCards organs/tissues related to Intestinal Perforation:

32
Small intestine, Bone, Colon, Liver, Lung, Testes, Bone marrow, Breast, Brain, Heart, Kidney, Uterus, Cervix, T cells

Animal Models for Intestinal Perforation or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Perforation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.6TRPC4AP, NOS1, NKX2-1, PTS

Publications for Intestinal Perforation

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Articles related to Intestinal Perforation:

(show top 50)    (show all 407)
idTitleAuthorsYear
1
Fetal intestinal perforation and meconium peritonitis associated with maternal autoimmune hepatitis. (24815708)
2014
2
Trends in the incidence of intestinal perforation in US dialysis patients (1992-2005). (22419235)
2013
3
Intestinal perforation caused by insertion of a nasogastric tube late after gastric bypass. (23382601)
2013
4
Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age. (22684157)
2013
5
Intestinal perforation after treatment of Burkitt's lymphoma: case report and review of the literature. (23414881)
2013
6
Host factors and typhoid fever-associated intestinal perforation in children in Nigeria. (22648130)
2012
7
Case report: delayed perforation after definitive treatment of focal intestinal perforation with a peritoneal drain. (22966475)
2012
8
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
9
Intestinal perforation caused by incidental ingestion of a fish bone. Value of CT in the diagnosis. (20883081)
2010
10
Delay in diagnosis and treatment of blunt intestinal perforation does not adversely affect prognosis in the pediatric trauma patient. (20386275)
2010
11
Fasciolopsiasis presenting as intestinal perforation: a case report. (19624087)
2009
12
Enteric fever with suspected intestinal perforation and incidental renal cell carcinoma--a case report. (18416351)
2007
13
New insights into spontaneous intestinal perforation using a national data set: (2) two populations of patients with perforations. (16493433)
2006
14
Spontaneous localized intestinal perforation and intestinal dilatation in very-low-birthweight infants. (17062464)
2006
15
Endometriosis with intestinal perforation in term pregnancy. (16545813)
2006
16
Intestinal perforation and jejunal haemorrhage due to Wegener's granulomatosis. (15789904)
2005
17
Intestinal perforation in Crohn's disease. Factors predictive of surgical resection. (16505755)
2005
18
Peritoneal drainage as definitive management of intestinal perforation in extremely low-birth-weight infants. (14666475)
2003
19
Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. (12368968)
2002
20
A rare complication of miliary tuberculosis: intestinal perforation. (11301949)
2001
21
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
22
Heroin body packing: three fatal cases of intestinal perforation. (10641918)
2000
23
Typhoid intestinal perforation in Nigerian children. (10610606)
1999
24
Intestinal perforation in terminally ill cancer patients: clinical characteristics. (10022672)
1999
25
Neonatal intestinal perforation caused by congenital defect of the small intestinal musculature: report of one case. (10910628)
1999
26
Intestinal perforation after renal transplantation. (9787962)
1998
27
Intestinal perforation by saline total gut lavage in occult diverticulitis. (9826157)
1998
28
Seat belt-induced intestinal perforation. (9115830)
1997
29
Percutaneous peritoneal drainage in the management of acute intestinal perforation. (9069065)
1997
30
Neonatal intestinal perforation caused by intestinal muscularis defect associated with vascular ectasia. (8796760)
1996
31
Intestinal perforation due to an ingested foreign body: laparoscopic management. (8832937)
1996
32
Intestinal perforation following removal of a closed suction: case report. (8598941)
1996
33
Anaphylactoid purpura with intestinal perforation: report of a case and review of the Japanese literature. (8044297)
1994
34
Intestinal perforation due to Mycobacterium tuberculosis in HIV-infected individuals: report of two cases. (8470647)
1993
35
Small intestinal perforation following minor trauma. (1446940)
1992
36
Intestinal herpes simplex infection presenting with intestinal perforation. (1415108)
1992
37
Localized intestinal perforation following intravenous indomethacin in premature infants. (2732888)
1989
38
Iopamidol in the diagnosis of suspected upper gastro-intestinal perforation. (3568550)
1987
39
Yersinia enterocolitica infection complicated by intestinal perforation. (3307674)
1987
40
Factors affecting mortality in small intestinal perforation. (3781581)
1986
41
Subcutaneous emphysema. A rare sign of intestinal perforation. (4078791)
1985
42
Small intestinal perforation in Wegener's granulomatosis. (7100026)
1982
43
Intestinal perforation in newborn following intrauterine meconium peritonitis. (450485)
1979
44
Spontaneous neonatal and fetal intestinal perforation. (897945)
1977
45
Intestinal perforation by ascaris. (1194689)
1975
46
URINARY EXCRETION OF GASTROGRAFIN AS A SIGN OF INTESTINAL PERFORATION. (14214170)
1964
47
A sign of intestinal perforation. (14476026)
1962
48
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959
49
Typhoid fever and intestinal perforation: Recovery with chloromycetin and dihydrostreptomycin. (14796868)
1950
50
Case of Acute Peritonitis following Intestinal Perforation. (20750624)
1883

Variations for Intestinal Perforation

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Expression for genes affiliated with Intestinal Perforation

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Expression patterns in normal tissues for genes affiliated with Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for genes affiliated with Intestinal Perforation

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Compounds for genes affiliated with Intestinal Perforation

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Intestinal Perforation according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1pteridine449.8NOS1, PTS
2sepiapterin44 2410.8NOS1, PTS
3pterin44 2410.8NOS1, PTS
4tetrahydrobiopterin44 24 1111.8PTS, NOS1
5cgmp44 2810.6NOS1, PTS
6formaldehyde44 2410.5NOS1, NKX2-1
7mucicarmine449.5NKX2-1, CEACAM3
8b 723449.4NKX2-1, CEACAM3
9hematoxylin449.4NKX2-1, CEACAM3
10carbon449.1NOS1, CEACAM3
11steroid448.9PTS, CEACAM3, NKX2-1
12aspartate448.9NOS1, CEACAM3, PTS
13nitric oxide44 24 1110.8NOS1, CEACAM3, PTS
14oxygen44 249.6PTS, CEACAM3, NOS1
15estrogen448.4NOS1, NKX2-1, CEACAM3

GO Terms for genes affiliated with Intestinal Perforation

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Products for genes affiliated with Intestinal Perforation

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  • Antibodies
  • Proteins
  • Lysates

Sources for Intestinal Perforation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet