MCID: INT071
MIFTS: 39

Intestinal Perforation malady

Gastrointestinal diseases category

Summaries for Intestinal Perforation

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gastrointestinal perforation is a complete penetration of any part of the wall of the gastrointestinal... more...

MalaCards: Intestinal Perforation, also known as perforation of intestine, is related to peritonitis and intestinal disease. An important gene associated with Intestinal Perforation is PTS (6-pyruvoyltetrahydropterin synthase). The compounds pteridine and sepiapterin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and bone.

Aliases & Classifications for Intestinal Perforation

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intestinal perforation 8 10 60
perforation of intestine 8


External Ids:

Disease Ontology8 DOID:2074
MeSH34 D007416
NCIt39 C39611
SNOMED-CT56 56905009
ICD9CM27 569.83
ICD1025 K63.1

Related Diseases for Intestinal Perforation

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis10.7
2intestinal disease10.6
3typhoid fever10.5
4wegener's granulomatosis10.5
5intestinal tuberculosis10.4
6tuberculosis10.4
7purpura10.3
8polyarteritis nodosa10.3
9miliary tuberculosis10.3
10perinatal intestinal perforation10.3
11behcet's disease10.2
12temporal arteritis10.2
13patent ductus arteriosus10.2
14intestinal obstruction10.2
15scleroderma10.2
16crohn's disease10.1
17intussusception10.1
18churg-strauss syndrome10.1
19bronchogenic carcinoma10.1
20arthritis10.1
21candidiasis10.1
22ehlers-danlos syndrome10.1
23hodgkin's lymphoma10.1
24liver disease10.1
25rheumatoid arthritis10.1
26vaginitis10.1
27cystadenocarcinoma10.0CEACAM3
28merkel cell carcinoma10.0NKX2-1
29malignant pleural mesothelioma10.0CEACAM3, NKX2-1
30large cell carcinoma10.0NKX2-1, CEACAM3
31hyperphenylalaninemia10.0PTS, NOS1
32thymus cancer10.0NKX2-1, CEACAM3
33thyroid medullary carcinoma10.0NKX2-1, CEACAM3
34benign mesothelioma10.0CEACAM3, NKX2-1
35neuroendocrine tumor10.0CEACAM3, NKX2-1
36papillary carcinoma10.0CEACAM3, NKX2-1
37burns10.0
38antiphospholipid syndrome10.0
39ascariasis10.0
40toxic megacolon10.0
41ankylosing spondylitis10.0
42cerebritis10.0
43gas gangrene10.0
44pleomorphic carcinoma10.0
45hemoglobinuria10.0
46alpha chain disease10.0
47portal hypertension10.0
48interdigitating dendritic cell sarcoma10.0
49angiodysplasia10.0
50gastrointestinal stromal tumor10.0

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to intestinal perforation

Clinical Features for Intestinal Perforation

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Drugs & Therapeutics for Intestinal Perforation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Intestinal Perforation

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Anatomical Context for Intestinal Perforation

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32MalaCards
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MalaCards organs/tissues related to Intestinal Perforation:

32
Small intestine, Colon, Bone, Lung, Liver, Testes, Breast, Bone marrow, Kidney, Heart, Ovary, Uterus, Brain, Cervix, T cells

Animal Models for Intestinal Perforation or affiliated genes

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Publications for Intestinal Perforation

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50PubMed
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Articles related to Intestinal Perforation:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age. (22684157)
2013
2
Intestinal perforation in gynecologic oncology: do all patients benefit from surgical management? (23500088)
2013
3
Genome-wide Expression Profiles of Necrotizing Enterocolitis Versus Spontaneous Intestinal Perforation in Human Intestinal Tissues: Dysregulation of Functional Pathways. (24368664)
2013
4
Parenteral-nutrition-associated liver disease after intestinal perforation in extremely low-birthweight infants: consequent lethal portal hypertension. (23240986)
2013
5
Henoch-Schonlein purpura with intestinal perforation and cerebral hemorrhage: a case report. (23674862)
2013
6
Mortality in typhoid intestinal perforation-a declining trend. (24179905)
2013
7
Comparative analysis of primary repair vs resection and anastomosis, with laparostomy, in management of typhoid intestinal perforation: results of a rural hospital in northwestern Benin. (23782915)
2013
8
Intestinal perforation due to concomitant cytomegalovirus infection during treatment for Pneumocystis jirovecii pneumonia in a patient with rheumatoid arthritis. (21881284)
2011
9
Outcome of surgical treatment of intestinal perforation in typhoid fever. (20806433)
2010
10
Fasciolopsiasis presenting as intestinal perforation: a case report. (19624087)
2009
11
Intestinal perforation associated with rituximab therapy for post-transplant lymphoproliferative disorder after liver transplantation. (19588139)
2009
12
Surgical management of necrotizing enterocolitis and isolated intestinal perforation in premature neonates. (18346536)
2008
13
Typhoid intestinal perforation in children: a continuing scourge in a developing country. (17086425)
2007
14
Small intestinal perforation and peritonitis after liposuction. (17659408)
2007
15
Intestinal obstruction by an enterolith from a perforated giant Meckel's diverticulum: diagnosis with CT reconstructed images. (17972465)
2007
16
Endometriosis with intestinal perforation in term pregnancy. (16545813)
2006
17
Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted age. (16549503)
2006
18
Comparative study between isolated intestinal perforation and necrotizing enterocolitis. (15877256)
2005
19
Typhoid intestinal perforation in north central Nigeria. (15909700)
2005
20
Veterinary diagnostic imaging. Longitudinal intestinal perforation at the level of the proximal duodenum near the pylorus resulting in a septic peritonitis. (16187722)
2005
21
Intestinal perforation following renal transplantation: report of 2 cases related to cytomegalovirus disease. (14612083)
2003
22
Enteropathy-associated T-cell lymphoma of the jejunum complicated with intestinal perforation. (12854879)
2003
23
A comparison of the clinical presentation and outcome of focal intestinal perforation and necrotizing enterocolitis in very-low-birth-weight neonates. (12598969)
2002
24
Perforation of small intestine inside an internal omphalocele after blunt trauma: case report and review of the literature. (11242304)
2001
25
Henoch-SchAPnlein purpura-related intestinal perforation: a steroid complication? (11472592)
2001
26
Repeated intestinal perforation caused by an incomplete form of BehAset's syndrome. (11555112)
2001
27
Rare complication of intestinal volvulus with perforation of the small bowel secondary to the peritoneal end of the ventriculoperitoneal shunt (VPS). (11315306)
2001
28
Factors associated with intestinal perforation in children's non-typhi Salmonella toxic megacolon. (11144376)
2000
29
Fatal intestinal perforation secondary to fragmentation of a Celestin tube. (11053950)
2000
30
Upper gastrointestinal bleeding and intestinal perforation due to multiple duodenojejunal metastases from a silent bronchogenic adenosquamous carcinoma. (9826154)
1998
31
Intestinal perforation in temporal arteritis, associated with paroxysmal nocturnal hemoglobinuria. (8680107)
1996
32
In-utero cocaine exposure and neonatal intestinal perforation: a case report. (8558622)
1995
33
Clinical comparison of localized intestinal perforation and necrotizing enterocolitis in neonates. (8265320)
1994
34
Intestinal perforation after ERCP in Billroth II partial gastrectomy. (8056259)
1994
35
Localized intestinal perforation. (7936919)
1994
36
Neonatal intestinal ischemia with bowel perforation: an in utero complication of maternal cocaine abuse. (1590129)
1992
37
Risks associated with intestinal perforation during experimental percutaneous drainage. (1473917)
1992
38
Intestinal perforation due to cytomegalovirus infection in patients with AIDS. (2173658)
1990
39
Subcutaneous emphysema. A rare sign of intestinal perforation. (4078791)
1985
40
Intestinal perforation associated with cytomegalovirus infection in patients with acquired immune deficiency syndrome. (6322576)
1984
41
Antepartum diagnosis and management of in utero intestinal volvulus with perforation. (6855825)
1983
42
Intestinal perforation caused by larval Eustrongylides - Maryland. (6813668)
1982
43
Pica. An unusual cause of intestinal perforation. (7407031)
1980
44
Nonsurgical treatment of intestinal perforation due to peritoneal dialysis. (4682261)
1973
45
Intestinal perforation in the newborn infant as a complication in umbilical vein infusion or exchange transfusion. (5099449)
1971
46
Intestinal perforation due to swallowed fish or meat bone. (4158955)
1966
47
Multiple intussusception and intestinal perforation due to a bezoar. (13707489)
1960
48
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959
49
Intestinal perforation complicating typhoid fever in children. (18866963)
1948
50
PNEUMOPERITONEUM: A METHOD OF DETECTING INTESTINAL PERFORATION-AN AID IN ABDOMINAL DIAGNOSIS. (17864165)
1919

Genetic Variations for Intestinal Perforation

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Expression for genes affiliated with Intestinal Perforation

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for genes affiliated with Intestinal Perforation

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Compounds for genes affiliated with Intestinal Perforation

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44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Intestinal Perforation according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pteridine449.8PTS, NOS1
2sepiapterin44 2410.8PTS, NOS1
3pterin44 2410.8PTS, NOS1
4tetrahydrobiopterin44 11 2411.6NOS1, PTS
5mucicarmine449.5CEACAM3, NKX2-1
6b 723449.3CEACAM3, NKX2-1
7hematoxylin449.1CEACAM3, NKX2-1
8aspartate449.0CEACAM3, PTS, NOS1

GO Terms for genes affiliated with Intestinal Perforation

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Products for genes affiliated with Intestinal Perforation

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intestinal Perforation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet