MCID: INT071
MIFTS: 44

Intestinal Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Perforation

MalaCards integrated aliases for Intestinal Perforation:

Name: Intestinal Perforation 12 41 14 69
Perforation of Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2074
ICD9CM 34 569.83
MeSH 41 D007416
NCIt 46 C39611
SNOMED-CT 64 56905009
ICD10 32 K63.1
UMLS 69 C0021845

Summaries for Intestinal Perforation

MalaCards based summary : Intestinal Perforation, also known as perforation of intestine, is related to pleomorphic carcinoma and spondyloarthropathy 1. An important gene associated with Intestinal Perforation is NFKB1 (Nuclear Factor Kappa B Subunit 1), and among its related pathways/superpathways are Innate Immune System and Doxorubicin Pathway, Pharmacokinetics. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intestinal Perforation

Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 pleomorphic carcinoma 30.0 KRT7 NKX2-1
2 spondyloarthropathy 1 28.9 CRP NOD2
3 perinatal intestinal perforation 12.3
4 hirschsprung disease 1 11.0
5 peritonitis 10.4
6 enterocolitis 10.4
7 autoinflammation with infantile enterocolitis 10.4
8 perinatal necrotizing enterocolitis 10.3
9 lung acinar adenocarcinoma 10.3 KRT7 NKX2-1
10 ovarian germ cell teratoma 10.3 KRT7 NKX2-1
11 small cell carcinoma of the bladder 10.3 KRT7 NKX2-1
12 ovarian germ cell cancer 10.3 KRT7 NKX2-1
13 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 NKX2-1
14 papillary adenoma 10.3 KRT7 NKX2-1
15 bronchiolo-alveolar adenocarcinoma 10.3 KRT7 NKX2-1
16 dyskinetic cerebral palsy 10.3 NKX2-1 PTS
17 papillary serous adenocarcinoma 10.3 KRT7 NKX2-1
18 pulmonary sclerosing hemangioma 10.3 KRT7 NKX2-1
19 atypical choroid plexus papilloma 10.3 KRT7 NKX2-1
20 sclerosing hemangioma 10.3 KRT7 NKX2-1
21 horseshoe kidney 10.2 KRT7 NKX2-1
22 cystic teratoma 10.2 KRT7 NKX2-1
23 tetrahydrobiopterin deficiency 10.2 NOS1 PTS
24 ovarian cystic teratoma 10.2 KRT7 NKX2-1
25 hidradenocarcinoma 10.2 KRT7 NKX2-1
26 mesenteric lymphadenitis 10.2 CRP NOD2
27 anal gland adenocarcinoma 10.2 CRP KRT7
28 benign mesothelioma 10.2 KRT7 NKX2-1
29 streptococcal meningitis 10.1 CRP NOD2
30 papillary adenocarcinoma 10.1 KRT7 NKX2-1
31 rete testis neoplasm 10.1 NCAM1 NKX2-1
32 typhoid fever 10.1
33 mucinous adenocarcinoma 10.1 KRT7 NKX2-1
34 ovarian large-cell neuroendocrine carcinoma 10.1 KRT7 NCAM1
35 renal adenoma 10.1 KRT7 NCAM1
36 epithelial predominant wilms' tumor 10.1 KRT7 NCAM1
37 pancreatic serous cystadenoma 10.1 KRT7 NCAM1
38 cystadenofibroma 10.0 KRT7 NCAM1
39 mycobacterium tuberculosis 1 10.0
40 pericoronitis 10.0 CRP NCAM1
41 intestinal obstruction 10.0 KRT7 NOD2
42 lymphoma 10.0
43 crohn's disease 9.9
44 purpura 9.9
45 nephrogenic adenofibroma 9.9 KRT7 NCAM1
46 aging 9.9
47 polyarteritis nodosa, childhood-onset 9.9
48 polyarteritis nodosa 9.9
49 miliary tuberculosis 9.9
50 cytomegalovirus infection 9.9

Comorbidity relations with Intestinal Perforation via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Paralytic Ileus Peritonitis
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Respiratory Failure

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to Intestinal Perforation

Symptoms & Phenotypes for Intestinal Perforation

GenomeRNAi Phenotypes related to Intestinal Perforation according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.4 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.4 CRP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.4 NOD2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7 NOD2 CRP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.4 NOD2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.4 CRP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 KRT7

MGI Mouse Phenotypes related to Intestinal Perforation:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 NFKB1 NKX2-1 NOD2 NOS1 PTS

Drugs & Therapeutics for Intestinal Perforation

Drugs for Intestinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 131)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Simethicone Approved Phase 3
4
Ampicillin Approved, Vet_approved Phase 2, Phase 3 69-53-4 6249
5
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
6
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
7
Piperacillin Approved Phase 2, Phase 3 66258-76-2 43672
8
Tazobactam Approved Phase 2, Phase 3 89786-04-9 123630
9
Histamine Approved, Investigational Phase 2, Phase 3 51-45-6, 75614-87-8 774
10
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
11
Meropenem Approved, Investigational Phase 3 119478-56-7 441130 64778
12
Cholecalciferol Approved, Nutraceutical Phase 2, Phase 3 67-97-0 10883523 5280795 6221
13
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
14
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
15
Butyric Acid Experimental, Investigational Phase 2, Phase 3 107-92-6 264
16 Antifungal Agents Phase 3
17 Anti-Infective Agents Phase 3,Phase 2
18 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 Hormone Antagonists Phase 3
21 Hormones Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
23 Steroid Synthesis Inhibitors Phase 3
24 Bone Density Conservation Agents Phase 2, Phase 3
25 Ergocalciferols Phase 2, Phase 3
26 Micronutrients Phase 2, Phase 3
27 Trace Elements Phase 2, Phase 3
28 Vitamins Phase 2, Phase 3
29 Anti-Bacterial Agents Phase 2, Phase 3
30 Antibiotics, Antitubercular Phase 2, Phase 3
31 Antiparasitic Agents Phase 2, Phase 3
32 Antiprotozoal Agents Phase 2, Phase 3
33 Antitubercular Agents Phase 2, Phase 3
34 beta-Lactamase Inhibitors Phase 2, Phase 3
35 Clindamycin palmitate Phase 2, Phase 3
36 Clindamycin phosphate Phase 2, Phase 3
37 Gentamicins Phase 2, Phase 3
38 Penicillanic Acid Phase 2, Phase 3
39 Piperacillin, tazobactam drug combination Phase 2, Phase 3
40 Pharmaceutical Solutions Phase 2, Phase 3, Phase 1
41 Histamine Antagonists Phase 2, Phase 3
42
Histamine Phosphate Phase 2, Phase 3 51-74-1 65513
43 Neurotransmitter Agents Phase 2, Phase 3
44 Amoxicillin-Potassium Clavulanate Combination Phase 3
45 Clavulanic Acid Phase 3
46 Thienamycins Phase 3
47 Cola Nutraceutical Phase 2, Phase 3,Phase 1
48 Calciferol Nutraceutical Phase 2, Phase 3
49 Vitamin D2 Nutraceutical Phase 2, Phase 3
50
Oxaliplatin Approved, Investigational Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054

Interventional clinical trials:

(show top 50) (show all 57)

# Name Status NCT ID Phase Drugs
1 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
2 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
3 Comparison of Infant Pain Responses Between Two Different Methods of Urine Collection Unknown status NCT00298584 Phase 3
4 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
5 Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation Completed NCT01233713 Phase 2, Phase 3
6 Vitamin D Supplementation for Extremely Preterm Infants Completed NCT01600430 Phase 2, Phase 3
7 Antibiotic Safety (SCAMP) Completed NCT01994993 Phase 2, Phase 3 ampicillin and metronidazole and gentamicin;ampicillin and gentamicin and clindamycin;gentamicin and Piperacillin- tazobactam;standard of care antibiotics and metronidazole;metronidazole, clindamycin, or piperacillin-tazobactam
8 Effects of Recto-colic Enemas of Butyrate on the Digestive Disorders of Very Low Birth Weight Preterms <1250 Grams Terminated NCT01536483 Phase 2, Phase 3 Butyrate enemas
9 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
10 IPHC in Patients With Platinum-sensitive Recurrent Ovarian Cancer Completed NCT01588964 Phase 2
11 Paclitaxel and Carboplatin With Or Without Sorafenib In The First-Line Treatment Of Patients With Ovarian Cancer Completed NCT00390611 Phase 2 Sorafenib;Paclitaxel;Carboplatin
12 Vargatef in Addition to First Line Chemotherapy With Interval Debulking Surgery in Patients With Ovarian Cancer Completed NCT01583322 Phase 2 vargatef;placebo
13 Vinorelbine and Bevacizumab in Treating Older Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Completed NCT00309998 Phase 2 vinorelbine tartrate
14 Effects of Extensive Abdominal Lavage on Postoperative Inflammation Following Full Thickness Excision of Deep Endometriosis Completed NCT00930696 Phase 2
15 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus Recruiting NCT01958320 Phase 2
16 CABI: Antibiotic Duration for Complicated Intra-ABdominal Infection Recruiting NCT03265834 Phase 2
17 Paracetamol in Patent Ductus Arteriosus Recruiting NCT02422966 Phase 2 Paracetamol;Ibuprofen
18 PIPAC for Peritoneal Metastases of Colorectal Cancer Not yet recruiting NCT03246321 Phase 1, Phase 2
19 Therapeutic Oxygen for Gastrointestinal Atony (TOGA) Recruiting NCT03386136 Phase 1 100% Oxygen
20 IRT in Infants With Intestinal Perforation Unknown status NCT01530828
21 Colonic Motility in Constipation and Ageing Unknown status NCT02575742
22 Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer Unknown status NCT00949273
23 Observational Study of Surgical Treatment of Necrotizing Enterocolotis Completed NCT01223261
24 Evaluation of the Ability to Detect Bowel Gas During Laparoscopic Surgery Completed NCT02679118
25 Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis Completed NCT01768936
26 Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy Completed NCT01306838
27 Effect of Continuous Thoracic Epidural Analgesia on Gut Motility Following Emergency Laparotomy Completed NCT03145389
28 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed NCT01674478
29 Splanchnic Oxygenation Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler. Completed NCT02971566
30 Host Immune Response to Clostridium Difficile Infection (ICD) Completed NCT02440438
31 Prediction of Feeding Problems in Prostaglandin-dependent Prematurely Born Infants With Congenital Heart Disease Completed NCT01126372
32 Proton Therapy for Unresectable Cancer (CA) of Pancreas Completed NCT00685763
33 Proton Radiation for Resectable Carcinoma of the Pancreas Completed NCT00763516
34 Clinical Study-evaluate Performance&Safety "Aer-O-Scope" in Colon of Low Risk Patients Completed NCT00867724
35 Efficacy and Safety of a New Polypectomy Snare for Cold-polypectomy for Small Colorectal Polyps Completed NCT02245854
36 Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis Completed NCT01784458
37 The Magnitude of Effect of PCP Counseling on Participation Rate and Sedation Rate in Colonoscopy-based Screening Program Completed NCT01688817
38 Comparison of Humidified High Flow Nasal Cannula to Nasal CPAP in Neonates Completed NCT00609882
39 Re-feeding Gastric Residuals in Preterm Infants Completed NCT01420263
40 Intestinal Colonization in Newborn Infants With Enterostomy Recruiting NCT03340259
41 Endosponge Vacuum Therapy (E-VAC) Registry of Intestinal Anastomotic Leaks and Perforations Recruiting NCT02477930
42 Naloxegol Health Outcomes PASS Recruiting NCT02813369 naloxegol;non-PAMORA laxative
43 Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit Recruiting NCT03198338 0.25% Bupivacaine, 0.5mL/kg;Normal Saline
44 Endoscopic Sphincterotomy vs. Balloon Dilation for Assessment of Pancreatitis Recruiting NCT02346448
45 Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation Recruiting NCT03388437
46 Does Routine Assessment of Gastric Residuals in Preterm Neonates Influence Time Taken to Reach Full Enteral Feeding? Recruiting NCT03111329
47 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II Recruiting NCT01604421
48 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I Recruiting NCT01604317
49 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III Recruiting NCT01604434
50 Point-of-Care Ultrasonography for Intussusception Recruiting NCT03360643

Search NIH Clinical Center for Intestinal Perforation

Cochrane evidence based reviews: intestinal perforation

Genetic Tests for Intestinal Perforation

Anatomical Context for Intestinal Perforation

MalaCards organs/tissues related to Intestinal Perforation:

38
Small Intestine, Colon, Bone, Pancreas, Lung, Heart, Liver

Publications for Intestinal Perforation

Articles related to Intestinal Perforation:

(show top 50) (show all 494)
# Title Authors Year
1
Polymicrobial Anaerobic Bacteremia Caused by Butyricimonas virosa and Brachyspira pilosicoli in a Patient with Peritonitis following Intestinal Perforation. ( 29071824 )
2018
2
Management of neonatal spontaneous intestinal perforation by peritoneal needle aspiration. ( 29120457 )
2018
3
Intestinal Perforation Associated With Perinatal Asphyxia and Anaemia. ( 29077644 )
2018
4
Intestinal perforation: an unusual complication of barium enema. ( 29085170 )
2017
5
Risk factors for spontaneous localized intestinal perforation in the preterm infant. ( 28671044 )
2017
6
Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review. ( 28567320 )
2017
7
Multiple small intestinal perforations in a patient with Hepatitis B Virus-associated Polyarteritis Nodosa. ( 28878877 )
2017
8
Intestinal perforation due to hemorrhagic Cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature. ( 28283734 )
2017
9
High prevalence of cytomegalovirus infection in surgical intestinal specimens from infants with necrotizing enterocolitis and spontaneous intestinal perforation: A retrospective observational study. ( 28633098 )
2017
10
Epidemiological, clinical, and therapeutic features of typhoid intestinal perforation in a rural environment of Burkina Faso. ( 28406420 )
2017
11
Intestinal perforation secondary to intestinal diffuse large b-cell lymphoma in a patient with coeliac disease. ( 29054322 )
2017
12
Intestinal perforation and peritonitis due to<i>Taenia saginata</i>: A case report from Iran. ( 29276585 )
2017
13
Typhoid intestinal perforation in developing countries: Still unavoidable deaths? ( 28373758 )
2017
14
Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria. ( 29277466 )
2017
15
Treatment and outcome of intestinal perforation after liver transplant surgery in adults: a single-center experience. ( 28615946 )
2017
16
Intestinal Perforation during the Stabilization Period in a Preterm Infant with Congenital Diaphragmatic Hernia. ( 28868233 )
2017
17
Neonatal Appendicitis as a Rare Cause of Intestinal Perforation in a Preterm Neonate. ( 28302241 )
2017
18
Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates. ( 28494498 )
2017
19
Modifiable risk factors for typhoid intestinal perforations during a large outbreak of typhoid fever, Kampala Uganda, 2015. ( 28946853 )
2017
20
A 14-year-old girl presenting with tuberculous intestinal perforation while in a temporary shelter after the 2015 earthquake in Nepal. ( 28121264 )
2017
21
Predictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition-Associated Cholestasis in Premature Infants With Intestinal Perforation. ( 28792861 )
2017
22
Delayed intestinal perforation and vertebral osteomyelitis after high-intensity focused ultrasound treatment for uterine leiomyoma. ( 28989929 )
2017
23
Congenital Infantile Fibrosarcoma Causing Intestinal Perforation in a Newborn. ( 28690909 )
2017
24
Combined use of high doses of vasopressin and corticosteroids in a patient with Crohn's disease with refractory septic shock after intestinal perforation: a case report. ( 29129185 )
2017
25
Intestinal perforation secondary to ingested foreign bodies: a single-center experience with 38 cases. ( 28251367 )
2017
26
Intestinal perforation in the premature infant. ( 28854518 )
2017
27
Intestinal perforation that developed after chemotherapy in a patient diagnosed with non-Hodgkin lymphoma: A case report and review of literature. ( 28898795 )
2017
28
A Single-Center Experience with Very Low Birth Weight Infants and Focal Intestinal Perforation: Comparison of Primary Anastomosis versus Stoma Opening. ( 28837996 )
2017
29
Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation. ( 27745748 )
2017
30
Intestinal perforation after nivolumab immunotherapy for a malignant melanoma: a case report. ( 28842844 )
2017
31
BehAset's disease with intestinal perforation: A case report. ( 27141811 )
2016
32
Intestinal Perforation in Obstructed Umbilical Hernia due to Wedged Plum Seed. ( 27398326 )
2016
33
Multiple Intestinal Perforation and Necrosis due to Magnet Ingestion. ( 28149151 )
2016
34
A Fatal Complication: Intestinal Perforation Secondary to Migration of a Biliary Stent. ( 27141238 )
2016
35
The antecedents and correlates of necrotizing enterocolitis and spontaneous intestinal perforation among infants born before the 28th week of gestation. ( 27197933 )
2016
36
Intestinal perforation due to paradoxical reaction during treatment for miliary tuberculosis. ( 28031831 )
2016
37
Intestinal perforation during chemotherapeutic treatment of intra-abdominal desmoid tumor in patients with Gardner's syndrome: report of two cases. ( 27377916 )
2016
38
NOD2 Loss-of-Function Mutations and Risks of Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low-birth-weight Infants. ( 26752461 )
2016
39
Spontaneous Intestinal Perforation: The Long-Term Outcome. ( 27846663 )
2016
40
Closure of an intestinal perforation with an autologous fat plug in a man with Crohn's disease. ( 27489994 )
2016
41
Intestinal perforation management using T-tube drainage. ( 27177890 )
2016
42
Effect of prophylactic indomethacin administration and early feeding on spontaneous intestinal perforation in extremely low-birth-weight infants. ( 27763630 )
2016
43
Spontaneous Intestinal Perforation in a Very Low Birth Weight Infant: Successful Management by Peritoneal Needle Suction. ( 27433457 )
2016
44
Congenital Mesenteric Defect: A Rare Cause of Intestinal Perforation. ( 27595576 )
2016
45
Surgical Necrotizing Enterocolitis versus Spontaneous Intestinal Perforation in White Matter Injury on Brain Magnetic Resonance Imaging. ( 27105356 )
2016
46
Intestinal Perforation Due to Foreign Body Ingestion in a Schizophrenic Patient. ( 27803892 )
2016
47
Subcutaneous Facial and Neck Emphysema as First Sign of Intestinal Perforation in a Female Patient After a Routine Colonoscopy. ( 28149153 )
2016
48
Intestinal Perforation in Renal Transplant Recipients: A Single Center Experience of 2123 Recipients. ( 27228089 )
2016
49
Intestinal perforation by an ingested foreign body. ( 27818542 )
2016
50
Henoch-SchAPnlein purpura from vasculitis to intestinal perforation: A case report and literature review. ( 27468201 )
2016

Variations for Intestinal Perforation

Expression for Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for Intestinal Perforation

Pathways related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 CRP DEFA1 DEFA4 NCAM1 NFKB1 NOD2
2
Show member pathways
10.76 NFKB1 NOS1
3 10.4 NFKB1 NOS1
4 9.98 NFKB1 NOD2

GO Terms for Intestinal Perforation

Biological processes related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral response GO:0019730 9.43 DEFA1 DEFA4
2 defense response to bacterium GO:0042742 9.43 DEFA1 DEFA4 NOD2
3 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.4 DEFA1 DEFA4
4 killing of cells of other organism GO:0031640 9.37 DEFA1 DEFA4
5 antibacterial humoral response GO:0019731 9.32 DEFA1 DEFA4
6 defense response to fungus GO:0050832 9.16 DEFA1 DEFA4
7 defense response GO:0006952 9.13 DEFA1 DEFA4 NOD2
8 defense response to Gram-positive bacterium GO:0050830 8.8 CRP DEFA1 DEFA4

Sources for Intestinal Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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