MCID: INT071
MIFTS: 42

Intestinal Perforation malady

Gastrointestinal diseases category
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Summaries for Intestinal Perforation

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65Wikipedia, 33MalaCards
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Wikipedia:65 Gastrointestinal perforation is a complete penetration of any part of the wall of the gastrointestinal... more...

MalaCards: Intestinal Perforation, also known as perforation of intestine, is related to melanoma and peritonitis. An important gene associated with Intestinal Perforation is PTS (6-pyruvoyltetrahydropterin synthase). The compounds pteridine and sepiapterin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, bone and colon, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Intestinal Perforation

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8Disease Ontology, 10DISEASES, 62UMLS, 27ICD9CM, 35MeSH, 40NCIt, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intestinal perforation 8 10 62
perforation of intestine 8


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Disease Ontology8 DOID:2074
ICD9CM27 569.83
MeSH35 D007416
SNOMED-CT58 56905009
NCIt40 C39611
ICD1025 K63.1

Related Diseases for Intestinal Perforation

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17GeneCards, 18GeneDecks
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Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma29.8NKX2-1, PTS, NOS1, CEACAM3
2peritonitis10.8
3typhoid fever10.6
4wegener's granulomatosis10.5
5tuberculosis10.4
6purpura10.3
7polyarteritis nodosa10.3
8miliary tuberculosis10.3
9perinatal intestinal perforation10.3
10cytomegalovirus infection10.3
11sepsis10.3
12patent ductus arteriosus10.2
13temporal arteritis10.2
14behcet's disease10.2
15scleroderma10.2
16degos disease10.2
17crohn's disease10.1
18intussusception10.1
19churg-strauss syndrome10.1
20arthritis10.1
21candidiasis10.1
22ehlers-danlos syndrome10.1
23hodgkin's lymphoma10.1
24rheumatoid arthritis10.1
25vaginitis10.1
26fibromatosis10.1
27thymus cancer10.0NKX2-1, CEACAM3
28malignant pleural mesothelioma10.0NKX2-1, CEACAM3
29large cell carcinoma10.0CEACAM3, NKX2-1
30thyroid medullary carcinoma10.0CEACAM3, NKX2-1
31thymoma10.0CEACAM3, NKX2-1
32malignant mesothelioma10.0NKX2-1, CEACAM3
33hyperphenylalaninemia10.0NOS1, PTS
34benign mesothelioma10.0CEACAM3, NKX2-1
35neuroendocrine tumor10.0CEACAM3, NKX2-1
36papillary carcinoma10.0CEACAM3, NKX2-1
37burns10.0
38ankylosing spondylitis10.0
39toxic megacolon10.0
40ascariasis10.0
41antiphospholipid syndrome10.0
42alpha chain disease10.0
43portal hypertension10.0
44gastrointestinal stromal tumor10.0
45angiodysplasia10.0
46interdigitating dendritic cell sarcoma10.0
47hemoglobinuria10.0
48eosinophilic gastroenteritis10.0
49acquired immunodeficiency syndrome10.0
50actinomycosis10.0

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to intestinal perforation

Symptoms for Intestinal Perforation

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Drugs & Therapeutics for Intestinal Perforation

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Intestinal Perforation

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Anatomical Context for Intestinal Perforation

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33MalaCards
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MalaCards organs/tissues related to Intestinal Perforation:

33
Small intestine, Bone, Colon, Liver, Lung, Testes, Breast, Bone marrow, Heart, Uterus, Kidney, T cells, Brain, Cervix

Animal Models for Intestinal Perforation or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Intestinal Perforation:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.6TRPC4AP, NOS1, NKX2-1, PTS

Publications for Intestinal Perforation

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52PubMed
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Articles related to Intestinal Perforation:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Trends in the incidence of intestinal perforation in US dialysis patients (1992-2005). (22419235)
2013
2
Intestinal perforation caused by insertion of a nasogastric tube late after gastric bypass. (23382601)
2013
3
Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age. (22684157)
2013
4
Intestinal perforation after treatment of Burkitt's lymphoma: case report and review of the literature. (23414881)
2013
5
Host factors and typhoid fever-associated intestinal perforation in children in Nigeria. (22648130)
2012
6
Case report: delayed perforation after definitive treatment of focal intestinal perforation with a peritoneal drain. (22966475)
2012
7
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
8
Intestinal perforation caused by incidental ingestion of a fish bone. Value of CT in the diagnosis. (20883081)
2010
9
Delay in diagnosis and treatment of blunt intestinal perforation does not adversely affect prognosis in the pediatric trauma patient. (20386275)
2010
10
Fasciolopsiasis presenting as intestinal perforation: a case report. (19624087)
2009
11
Enteric fever with suspected intestinal perforation and incidental renal cell carcinoma--a case report. (18416351)
2007
12
New insights into spontaneous intestinal perforation using a national data set: (2) two populations of patients with perforations. (16493433)
2006
13
Spontaneous localized intestinal perforation and intestinal dilatation in very-low-birthweight infants. (17062464)
2006
14
Endometriosis with intestinal perforation in term pregnancy. (16545813)
2006
15
Intestinal perforation and jejunal haemorrhage due to Wegener's granulomatosis. (15789904)
2005
16
Intestinal perforation in Crohn's disease. Factors predictive of surgical resection. (16505755)
2005
17
Peritoneal drainage as definitive management of intestinal perforation in extremely low-birth-weight infants. (14666475)
2003
18
Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. (12368968)
2002
19
A rare complication of miliary tuberculosis: intestinal perforation. (11301949)
2001
20
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
21
Heroin body packing: three fatal cases of intestinal perforation. (10641918)
2000
22
Typhoid intestinal perforation in Nigerian children. (10610606)
1999
23
Intestinal perforation in terminally ill cancer patients: clinical characteristics. (10022672)
1999
24
Neonatal intestinal perforation caused by congenital defect of the small intestinal musculature: report of one case. (10910628)
1999
25
Intestinal perforation after renal transplantation. (9787962)
1998
26
Intestinal perforation by saline total gut lavage in occult diverticulitis. (9826157)
1998
27
Seat belt-induced intestinal perforation. (9115830)
1997
28
Percutaneous peritoneal drainage in the management of acute intestinal perforation. (9069065)
1997
29
Neonatal intestinal perforation caused by intestinal muscularis defect associated with vascular ectasia. (8796760)
1996
30
Intestinal perforation due to an ingested foreign body: laparoscopic management. (8832937)
1996
31
Intestinal perforation following removal of a closed suction: case report. (8598941)
1996
32
Anaphylactoid purpura with intestinal perforation: report of a case and review of the Japanese literature. (8044297)
1994
33
Intestinal perforation due to Mycobacterium tuberculosis in HIV-infected individuals: report of two cases. (8470647)
1993
34
Small intestinal perforation following minor trauma. (1446940)
1992
35
Intestinal herpes simplex infection presenting with intestinal perforation. (1415108)
1992
36
Localized intestinal perforation following intravenous indomethacin in premature infants. (2732888)
1989
37
Iopamidol in the diagnosis of suspected upper gastro-intestinal perforation. (3568550)
1987
38
Yersinia enterocolitica infection complicated by intestinal perforation. (3307674)
1987
39
Factors affecting mortality in small intestinal perforation. (3781581)
1986
40
Intestinal perforation in typhoid fever: a historical and state-of-the-art review. (3890098)
1985
41
Subcutaneous emphysema. A rare sign of intestinal perforation. (4078791)
1985
42
Small intestinal perforation in Wegener's granulomatosis. (7100026)
1982
43
Intestinal perforation in newborn following intrauterine meconium peritonitis. (450485)
1979
44
Spontaneous neonatal and fetal intestinal perforation. (897945)
1977
45
Intestinal perforation by ascaris. (1194689)
1975
46
URINARY EXCRETION OF GASTROGRAFIN AS A SIGN OF INTESTINAL PERFORATION. (14214170)
1964
47
A sign of intestinal perforation. (14476026)
1962
48
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959
49
Typhoid fever and intestinal perforation: Recovery with chloromycetin and dihydrostreptomycin. (14796868)
1950
50
Case of Acute Peritonitis following Intestinal Perforation. (20750624)
1883

Variations for Intestinal Perforation

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Expression for genes affiliated with Intestinal Perforation

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for genes affiliated with Intestinal Perforation

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Compounds for genes affiliated with Intestinal Perforation

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR
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Compounds related to Intestinal Perforation according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1pteridine459.8PTS, NOS1
2sepiapterin45 2410.8PTS, NOS1
3pterin45 2410.8PTS, NOS1
4tetrahydrobiopterin45 24 1111.8PTS, NOS1
5cgmp45 2910.6NOS1, PTS
6formaldehyde45 2410.5NKX2-1, NOS1
7mucicarmine459.5CEACAM3, NKX2-1
8b 723459.4CEACAM3, NKX2-1
9hematoxylin459.4NKX2-1, CEACAM3
10carbon459.1CEACAM3, NOS1
11steroid458.9CEACAM3, NKX2-1, PTS
12aspartate458.9PTS, CEACAM3, NOS1
13nitric oxide45 24 1110.8CEACAM3, PTS, NOS1
14oxygen45 249.6NOS1, PTS, CEACAM3
15estrogen458.4NOS1, CEACAM3, NKX2-1

GO Terms for genes affiliated with Intestinal Perforation

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Products for genes affiliated with Intestinal Perforation

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  • Antibodies
  • Proteins
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Sources for Intestinal Perforation

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet