MCID: INT071
MIFTS: 39

Intestinal Perforation malady

Gastrointestinal diseases category

Summaries for Intestinal Perforation

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gastrointestinal perforation is a complete penetration of any part of the wall of the gastrointestinal... more...

MalaCards: Intestinal Perforation, also known as perforation of intestine, is related to peritonitis and intestinal disease. An important gene associated with Intestinal Perforation is PTS (6-pyruvoyltetrahydropterin synthase). The compounds pteridine and sepiapterin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and bone.

Aliases & Classifications for Intestinal Perforation

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intestinal perforation 8 10 60
perforation of intestine 8


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Disease Ontology8 DOID:2074
MeSH34 D007416
NCIt39 C39611
SNOMED-CT56 56905009
ICD9CM27 569.83
ICD1025 K63.1

Related Diseases for Intestinal Perforation

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis10.7
2intestinal disease10.6
3typhoid fever10.5
4wegener's granulomatosis10.5
5intestinal tuberculosis10.4
6tuberculosis10.4
7purpura10.3
8polyarteritis nodosa10.3
9miliary tuberculosis10.3
10perinatal intestinal perforation10.3
11behcet's disease10.2
12temporal arteritis10.2
13patent ductus arteriosus10.2
14intestinal obstruction10.2
15scleroderma10.2
16crohn's disease10.1
17intussusception10.1
18churg-strauss syndrome10.1
19bronchogenic carcinoma10.1
20arthritis10.1
21candidiasis10.1
22ehlers-danlos syndrome10.1
23hodgkin's lymphoma10.1
24liver disease10.1
25rheumatoid arthritis10.1
26vaginitis10.1
27cystadenocarcinoma10.0CEACAM3
28merkel cell carcinoma10.0NKX2-1
29malignant pleural mesothelioma10.0CEACAM3, NKX2-1
30large cell carcinoma10.0NKX2-1, CEACAM3
31hyperphenylalaninemia10.0PTS, NOS1
32thymus cancer10.0NKX2-1, CEACAM3
33thyroid medullary carcinoma10.0NKX2-1, CEACAM3
34benign mesothelioma10.0CEACAM3, NKX2-1
35neuroendocrine tumor10.0CEACAM3, NKX2-1
36papillary carcinoma10.0CEACAM3, NKX2-1
37burns10.0
38antiphospholipid syndrome10.0
39ascariasis10.0
40toxic megacolon10.0
41ankylosing spondylitis10.0
42cerebritis10.0
43gas gangrene10.0
44pleomorphic carcinoma10.0
45hemoglobinuria10.0
46alpha chain disease10.0
47portal hypertension10.0
48interdigitating dendritic cell sarcoma10.0
49angiodysplasia10.0
50gastrointestinal stromal tumor10.0

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to intestinal perforation

Clinical Features for Intestinal Perforation

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Drugs & Therapeutics for Intestinal Perforation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Intestinal Perforation

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Anatomical Context for Intestinal Perforation

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32MalaCards
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MalaCards organs/tissues related to Intestinal Perforation:

32
Small intestine, Colon, Bone, Lung, Testes, Liver, Breast, Bone marrow, T cells, Heart, Uterus, Kidney, Brain, Ovary, Cervix

Animal Models for Intestinal Perforation or affiliated genes

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Publications for Intestinal Perforation

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50PubMed
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Articles related to Intestinal Perforation:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
Multiple intestinal strictures with perforation in a patient under antitubercular treatment for abdominal tuberculosis. (23787535)
2013
2
Intestinal perforation after treatment of Burkitt's lymphoma: case report and review of the literature. (23414881)
2013
3
"Illuminating" - early diagnosis of intestinal perforation in a neonate. (24096854)
2013
4
Immunoregulatory protein profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in preterm infants. (22606320)
2012
5
Is intraabdominal drainage necessary after laparotomy for typhoid intestinal perforation? (22325389)
2012
6
A fatal case of Degos' disease which presented with recurrent intestinal perforation. (22110848)
2011
7
Spontaneous perforation of the small intestine, a novel manifestation of classical homocystinuria in an adult with new cystathionine beta-synthetase gene mutations. (21661368)
2011
8
Cholecystocolonic fistula prevents upper intestinal obstruction by a large gallstone after perforation into the duodenum. (19526247)
2010
9
A case of spontaneous intestinal perforation in osteogenesis imperfecta. (21629540)
2010
10
Intestinal perforation as a complication of balloon-assisted enteroscopy. (20886411)
2010
11
Prior uterine perforation resulting in intestinal obstruction in a subsequent pregnancy. (20706758)
2010
12
Late-onset intestinal perforation in the setting of posttransplantation microangiopathy: a case report. (21094879)
2010
13
A case of polyarteritis nodosa diagnosed after recurrent, multiple intestinal perforations. (19330740)
2009
14
Typhoid intestinal disease: 32 perforations in 1 patient. (18408786)
2008
15
Multiple jejunoileal perforations because of intestinal involvement of miliary tuberculosis in an infant. (18778982)
2008
16
Maternal factors in extremely low birth weight infants who develop spontaneous intestinal perforation. (17998314)
2007
17
A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. (18030227)
2007
18
The use of intravenous immunoglobulin in cutaneous and recurrent perforating intestinal Degos disease (malignant atrophic papulosis). (17501950)
2007
19
New insights into spontaneous intestinal perforation using a national data set: (2) two populations of patients with perforations. (16493433)
2006
20
Gastric pneumatosis intestinalis: an indicator of intestinal perforation in preterm infants with necrotizing enterocolitis? (17033533)
2006
21
Benign cystic teratoma of ovary perforating into small intestine with co-existent typhoid fever. (16361767)
2005
22
Intestinal perforation as a long-term complication of plug and mesh inguinal hernioplasty: case report. (15290610)
2005
23
Intestinal perforation after combined liver-kidney transplantation for a case of congenital polycystic disease. (15309740)
2004
24
Factors effecting morbidity in typhoid intestinal perforation in children. (12598967)
2002
25
Small intestine perforation because of capacitive coupling as a cause of abdominal wall gas gangrene and clostridial sepsis after laparoscopic cholecystectomy. (11147921)
2000
26
Intestinal perforation secondary to Salmonella typhi: case report and review of the literature. (10695758)
2000
27
Idiopathic gastric perforation in neonates and abnormal distribution of intestinal pacemaker cells. (10813320)
2000
28
Peritoneal drainage as definitive treatment for intestinal perforation in infants with extremely low birth weight (<750 g). (9498420)
1998
29
Neonatal intestinal perforation caused by intestinal muscularis defect associated with vascular ectasia. (8796760)
1996
30
Intestinal perforation from gastrointestinal histoplasmosis in acquired immunodeficiency syndrome. Case report and review of the literature. (8457161)
1993
31
A rare case of perineal pain: intestinal perforation caused by a press-through package. (1510270)
1992
32
Renal excretion of enteral gastrografin in the absence of free intestinal perforation. (2306915)
1990
33
Intestinal perforation caused by larval Eustrongylides (Nematoda: Dioctophymatoidae) in New Jersey. (2742040)
1989
34
Small intestinal perforation in Wegener's granulomatosis. (2746597)
1989
35
Iopamidol in the diagnosis of suspected upper gastro-intestinal perforation. (3568550)
1987
36
Intestinal perforation due to blunt trauma in children in an era of increased nonoperative treatment. (3701896)
1986
37
Typhoid fever complicated by intestinal perforation: a persisting fatal disease requiring surgical management. (3890097)
1985
38
Intestinal perforation associated with osmotic slow release indomethacin capsules. (6419882)
1984
39
Intestinal perforation associated with osmotic slow release indomethacin capsules. (6416544)
1983
40
The effect of experimentally induced intestinal perforation at an early developmental stage. (7338753)
1981
41
Intestinal perforation in typhoid fever. (757905)
1978
42
Emphysema of the leg as a presenting sign of large-intestinal perforation: report of two cases. (844399)
1977
43
Small intestinal perforation due to secondaries from Bronchogenic carcinoma. (952722)
1976
44
Prenatal intestinal perforation associated with meconium pseudocyst and ileal angiomatous malformation. (4635529)
1972
45
PERFORATION OF THE SMALL INTESTINE SECONDARY TO NECROTIZING VASCULITIS (PERIARTERITIS NODOSA). (14308799)
1965
46
Intestinal perforation and facial fractures in an automobile accident victim wearing a seat belt. (14011403)
1963
47
Intestinal perforation resulting from atmospheric blast. (20265503)
1947
48
Intestinal perforation in paratyphoid due to Salmonella paratyphi B. (21019994)
1946
49
Primary Intestinal Tuberculosis in Children: Perforation of Ulcers. (20761558)
1904
50
Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas. (17856254)
1888

Genetic Variations for Intestinal Perforation

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Expression for genes affiliated with Intestinal Perforation

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for genes affiliated with Intestinal Perforation

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Compounds for genes affiliated with Intestinal Perforation

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44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Intestinal Perforation according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pteridine449.8NOS1, PTS
2sepiapterin44 2410.8NOS1, PTS
3pterin44 2410.8NOS1, PTS
4tetrahydrobiopterin44 11 2411.6NOS1, PTS
5mucicarmine449.5NKX2-1, CEACAM3
6b 723449.3NKX2-1, CEACAM3
7hematoxylin449.1NKX2-1, CEACAM3
8aspartate449.0NOS1, PTS, CEACAM3

GO Terms for genes affiliated with Intestinal Perforation

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Products for genes affiliated with Intestinal Perforation

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intestinal Perforation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet