IPO
MCID: INT072
MIFTS: 35

Intestinal Pseudo-Obstruction (IPO) malady

Summaries for Intestinal Pseudo-Obstruction

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. it may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. the condition is sometimes inherited (in an x-linked recessive or autosomal dominant manner) and may be caused by mutations in the flna gene; it may also be acquired after certain illnesses. the goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. last updated: 5/10/2011

MalaCards: Intestinal Pseudo-Obstruction, also known as congenital short bowel syndrome, is related to paralytic ileus and systemic lupus erythematosus. An important gene associated with Intestinal Pseudo-Obstruction is FLNA (filamin A, alpha).

Genetics Home Reference:21 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia:64 Intestinal Pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Description from OMIM:47 615237,300048

Aliases & Classifications for Intestinal Pseudo-Obstruction

Sources:
21Genetics Home Reference, 61UMLS, 8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 47OMIM, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

intestinal pseudo-obstruction 8 43 21 10 45 61
congenital short bowel syndrome 21 47
hollow visceral myopathy 43 61
paralytic ileus 21 61
congenital idiopathic intestinal pseudoobstruction 61
chronic idiopathic intestinal pseudo-obstruction 21
pseudo-obstruction of gastrointestinal tract 61
pseudointestinal obstruction syndrome 21
pseudo-obstruction of intestine 8
intestinal pseudoobstruction 43
intestine pseudoobstruction 8
pseudoobstructive syndrome 21
enteric neuropathy 21
ciip 21
ipo 21


External Ids:

Disease Ontology8 DOID:3878
MeSH35 D007418
SNOMED-CT57 235825006
NCIt40 C34733

Related Diseases for Intestinal Pseudo-Obstruction

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Intestinal Pseudo-Obstruction family:

intestinal obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1paralytic ileus11.3
2systemic lupus erythematosus10.7
3short bowel syndrome10.7
4short syndrome10.7
5amyloidosis10.6
6thymoma10.6
7intestinal pseudoobstruction neuronal chronic idiopathic x-linked10.5
8natal teeth, intestinal pseudoobstruction and patent ductus10.5
9appendicitis10.5
10strongyloidiasis10.5
11megaduodenum and/or megacystis10.4
12chronic intestinal failure10.4
13kawasaki disease10.4
14colonic pseudo-obstruction10.4
15ogilvie syndrome10.4
16intestinal pseudoobstruction, neuronal10.4
17ileus10.4
18acute pancreatitis10.3
19small cell carcinoma10.3
20muscular atrophy10.3
21gastroparesis10.3
22pneumatosis cystoides intestinalis10.3
23pheochromocytoma10.3
24autonomic dysfunction10.3
25pancreatitis, chronic10.3
26hydrocephalus with congenital idiopathic intestinal pseudoobstruction10.3
27myopathic intestinal pseudoobstruction10.3
28unclassified intestinal pseudoobstruction10.3
29anuria10.2
30chronic interstitial cystitis10.2
31henoch-schoenlein purpura10.2
32gitelman syndrome10.2
33vipoma10.2
34protein-losing enteropathy10.2
35ulcerative colitis10.2
36herpes zoster10.2
37erythropoietic protoporphyria10.2
38autosomal dominant disease10.2
39thrombophlebitis10.2
40polycystic kidney disease, autosomal dominant10.2
41acute myelomonocytic leukemia10.2
42guillain-barr� syndrome10.2
43spinal cord injury10.2
44neurofibromatosis10.1
45alcohol abuse10.1
46myelitis10.1
47acute diarrhea10.1
48hemophagocytic lymphohistiocytosis10.1
49proctitis10.1
50somatostatinoma10.1

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Clinical Features for Intestinal Pseudo-Obstruction

Sources:
47OMIM
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Clinical features from OMIM:

615237,300048

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Intestinal Pseudo-Obstruction

Drug clinical trials:

Search ClinicalTrials for Intestinal Pseudo-Obstruction

Search NIH Clinical Center for Intestinal Pseudo-Obstruction

Search CenterWatch for Intestinal Pseudo-Obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

Anatomical Context for Intestinal Pseudo-Obstruction

Animal Models for Intestinal Pseudo-Obstruction or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Intestinal Pseudo-Obstruction

Sources:
51PubMed
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Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 418)
idTitleAuthorsYear
1
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. (24177421)
2013
2
Detection of anticonductive tissue autoantibodies in a patient with chronic intestinal pseudo-obstruction and sick sinus syndrome. (24081107)
2013
3
Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction. (23018539)
2012
4
Massive gastric distension from chronic intestinal pseudo-obstruction. (22461937)
2012
5
Major gastrointestinal manifestations in lupus patients in Asia: lupus enteritis, intestinal pseudo-obstruction, and protein-losing gastroenteropathy. (20947549)
2010
6
Chronic intestinal pseudo-obstruction and neurological manifestations in early adulthood: considering MNGIE syndrome in differential diagnosis. (20593055)
2010
7
Successful treatment of a female with chronic pseudo-intestinal obstruction with sympathomimetic amines and thyroid hormone replacement. (21077500)
2010
8
Intestinal pseudo-obstruction due to mitochondrial cytopathy. (20795984)
2010
9
Frequency of mitochondrial defects in patients with chronic intestinal pseudo-obstruction. (19344718)
2009
10
Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility. (19136514)
2009
11
Functional status, health-related quality of life and symptom severity in patients with chronic intestinal pseudo-obstruction and enteric dysmotility. (19308798)
2009
12
A case of chronic intestinal pseudo-obstruction secondary to primary visceral myopathy. (18779848)
2008
13
Autoimmune enteric leiomyositis: a rare cause of chronic intestinal pseudo-obstruction with specific morphological features. (15948126)
2005
14
Chronic intestinal pseudo-obstruction in a cat caused by visceral myopathy. (15715058)
2005
15
Prokinetics in the treatment of acute intestinal pseudo-obstruction. (15057661)
2004
16
Intestinal pseudo-obstruction in systemic lupus erythematosus. (12892261)
2003
17
Indication for small bowel transplant in patients affected by chronic intestinal pseudo-obstruction. (12034212)
2002
18
Submucosal hypoganglionosis causing chronic idiopathic intestinal pseudo-obstruction. (11873768)
2002
19
Nutritional management of pediatric patients with chronic intestinal pseudo-obstruction syndrome. (11321423)
2001
20
Chronic intestinal pseudo-obstruction: the pathologist's perspective. (11321413)
2001
21
Intestinal pseudo-obstruction and acute pandysautonomia associated with Epstein-Barr virus infection. (10638598)
2000
22
Chronic Intestinal Pseudo-obstruction. (11097724)
1999
23
Intestinal pseudo-obstruction. (10073262)
1999
24
Autonomic dysfunction in chronic intestinal pseudo-obstruction. (9869551)
1998
25
Successful pregnancy in a patient with chronic intestinal pseudo-obstruction while on ambulatory percutaneous endoscopic gastrostomy feeding. (9262982)
1997
26
Intestinal pseudo-obstruction as a paraneoplastic manifestation of malignant thymoma. (9317092)
1997
27
Cisapride as a successful treatment for acute intestinal pseudo-obstruction. (8701389)
1996
28
Chronic intestinal pseudo-obstruction associated with cytomegalovirus infection in an infant. (8956187)
1996
29
Intestinal motility during ontogeny and intestinal pseudo-obstruction in children. (8614613)
1996
30
Chronic intestinal pseudo-obstruction. (16843968)
1995
31
Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies. (8291223)
1993
32
Colonic manometry in children with chronic intestinal pseudo-obstruction. (8314513)
1993
33
Intestinal dysmotility-pseudo-obstruction]. (1503866)
1992
34
Intestinal pseudo-obstruction in myotonic dystrophy. (1453429)
1992
35
Acute and chronic intestinal pseudo-obstruction. (2024582)
1991
36
Visceral neuropathies responsible for chronic intestinal pseudo-obstruction syndrome in pediatric practice: analysis of 26 cases. (2395057)
1990
37
Intestinal pseudo obstruction with galactorrhoea. (2632549)
1989
38
Chronic intestinal pseudo-obstruction in patients with extensive bowel resection for Crohn's disease. (3387904)
1988
39
Successful management of chronic intestinal pseudo-obstruction with home parenteral nutrition. (3921733)
1985
40
Coeliac disease presenting with intestinal pseudo-obstruction. (6547920)
1984
41
Bacteriological findings in a case of chronic idiopathic intestinal pseudo-obstruction. (6897897)
1982
42
Intestinal pseudo-obstruction. (514177)
1979
43
Idiopathic intestinal pseudo-obstruction. (507197)
1979
44
Intestinal pseudo-obstruction in mucocutaneous lymph-node syndrome. (424532)
1979
45
Idiopathic intestinal pseudo-obstruction. (755084)
1978
46
Gastrointestinal myoelectrical activity in idiopathic intestinal pseudo-obstruction. (876299)
1977
47
Intestinal pseudo-obstruction. (4694418)
1973
48
Idiopathic intestinal pseudo-obstruction. (5037793)
1972
49
Chronic idiopathic intestinal pseudo-obstruction. (5452942)
1970
50
Idiopathic steatorrhoea with intestinal pseudo-obstruction. (18668747)
1962

Genetic Variations for Intestinal Pseudo-Obstruction

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Intestinal Pseudo-Obstruction:

63
id Symbol AA change Variation SNP ID
1CLMPp.Val124AspVAR_069713

Expression for genes affiliated with Intestinal Pseudo-Obstruction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Pseudo-Obstruction

Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for genes affiliated with Intestinal Pseudo-Obstruction

Compounds for genes affiliated with Intestinal Pseudo-Obstruction

GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

Sources:
16Gene Ontology
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Cellular components related to Intestinal Pseudo-Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.1CLMP, FLNA

Products for genes affiliated with Intestinal Pseudo-Obstruction

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Sources for Intestinal Pseudo-Obstruction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet