IPO
MCID: INT072
MIFTS: 42

Intestinal Pseudo-Obstruction (IPO) malady

Gastrointestinal diseases, Neuronal diseases categories

Summaries for Intestinal Pseudo-Obstruction

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42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. it may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. the condition is sometimes inherited (in an x-linked recessive or autosomal dominant manner) and may be caused by mutations in the flna gene; it may also be acquired after certain illnesses. the goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. last updated: 5/10/2011

MalaCards: Intestinal Pseudo-Obstruction, also known as congenital short bowel syndrome, is related to paralytic ileus and systemic lupus erythematosus. An important gene associated with Intestinal Pseudo-Obstruction is FLNA (filamin A, alpha). Affiliated tissues include small intestine, liver and smooth muscle.

Genetics Home Reference:21 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia:63 Intestinal Pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Description from OMIM:46 615237,300048

Aliases & Classifications for Intestinal Pseudo-Obstruction

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21Genetics Home Reference, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 46OMIM, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Neuronal diseases


Aliases & Descriptions:

intestinal pseudo-obstruction 8 42 21 10 44 60
congenital short bowel syndrome 21 46
hollow visceral myopathy 42 60
paralytic ileus 21 60
congenital idiopathic intestinal pseudoobstruction 60
chronic idiopathic intestinal pseudo-obstruction 21
pseudo-obstruction of gastrointestinal tract 60
pseudointestinal obstruction syndrome 21
pseudo-obstruction of intestine 8
intestinal pseudoobstruction 42
intestine pseudoobstruction 8
pseudoobstructive syndrome 21
enteric neuropathy 21
ciip 21
ipo 21


External Ids:

Disease Ontology8 DOID:3878
MeSH34 D007418
SNOMED-CT56 235825006
NCIt39 C34733

Related Diseases for Intestinal Pseudo-Obstruction

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Intestinal Pseudo-Obstruction family:

Intestinal Obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1paralytic ileus11.2
2systemic lupus erythematosus10.7
3lupus erythematosus10.7
4short bowel syndrome10.6
5myopathy10.6
6amyloidosis10.6
7neuronitis10.5
8colonic pseudo-obstruction10.5
9thymoma10.5
10intestinal pseudoobstruction neuronal chronic idiopathic x-linked10.5
11natal teeth, intestinal pseudoobstruction and patent ductus10.5
12appendicitis10.5
13myasthenia gravis10.4
14strongyloidiasis10.4
15kawasaki disease10.4
16myotonic dystrophy10.4
17hypothyroidism10.3
18small cell carcinoma10.3
19gastroparesis10.3
20pneumatosis cystoides intestinalis10.3
21diarrhea10.3
22intestinal perforation10.3
23lung small cell carcinoma10.3
24multiple sclerosis10.3
25ophthalmoplegia10.3
26pheochromocytoma10.3
27acute pancreatitis10.3
28schizophrenia10.3
29megaduodenum and/or megacystis10.3
30ganglioneuroblastoma10.2
31hydrocephalus with congenital idiopathic intestinal pseudoobstruction10.2
32myopathic intestinal pseudoobstruction10.2
33unclassified intestinal pseudoobstruction10.2
34parkinson's disease10.1
35neurofibromatosis10.1
36alcohol abuse10.1
37myelitis10.1
38acute diarrhea10.1
39hemophagocytic lymphohistiocytosis10.1
40proctitis10.1
41somatostatinoma10.1
42pancreatic somatostatinoma10.1
43mixed connective tissue disease10.1
44hypoparathyroidism10.1
45achalasia10.1
46neurogenic bladder10.1
47adult spinal muscular atrophy10.1
48capillariasis10.1
49multiple mucosal neuroma10.1
50myxedema10.1

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Clinical Features for Intestinal Pseudo-Obstruction

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46OMIM
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Clinical features from OMIM:

615237,300048

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Intestinal Pseudo-Obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

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Anatomical Context for Intestinal Pseudo-Obstruction

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32MalaCards
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MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

32
Small intestine, Liver, Smooth muscle, Colon, Lung, Lymph node

Animal Models for Intestinal Pseudo-Obstruction or affiliated genes

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Publications for Intestinal Pseudo-Obstruction

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50PubMed
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Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 414)
idTitleAuthorsYear
1
Non-transplantation surgical approach for chronic intestinal pseudo-obstruction: analysis of 63 adult consecutive cases. (23895212)
2013
2
Visceral Smooth Muscle I+-Actin Deficiency Associated With Chronic Intestinal Pseudo-obstruction in a Bengal Cat (Felis catus x Prionailurus bengalensis). (23774747)
2013
3
Endoscopic-assisted colopexy and push percutaneous colostomy in the transverse colon for refractory chronic intestinal pseudo-obstruction. (22146183)
2011
4
Familial intestinal degenerative neuropathy associated with chronic intestinal pseudo-obstruction. (21122031)
2011
5
Clinical picture of intestinal pseudo-obstruction syndrome. (22235480)
2011
6
Enteral nutrition for severe malnutrition in chronic intestinal pseudo-obstruction. (20018487)
2010
7
Vincristine and intestinal pseudo-obstruction in children: report of 5 cases, literature review, and suggested management. (20418785)
2010
8
Long-term outcome of chronic intestinal pseudo-obstruction adult patients requiring home parenteral nutrition. (19367271)
2009
9
Effect of the herbal medicine dai-kenchu-to on gastrointestinal motility in patients with megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) and chronic idiopathic intestinal pseudo-obstruction (CIIP): report of two cases. (21318994)
2009
10
Chronic intestinal pseudo-obstruction in patients with systemic lupus erythematosus: report of four cases. (17938989)
2008
11
Chronic intestinal pseudo-obstruction. (18494042)
2008
12
Prenatal diagnosis of intestinal pseudo-obstruction. (17252528)
2007
13
Strongyloides stercoralis mesenteric lymphadenopathy: clue to the etiopathogenesis of intestinal pseudo-obstruction in HIV-infected patients. (16844562)
2006
14
Chronic primary intestinal pseudo-obstruction from visceral myopathy. (16792457)
2006
15
Splenic flexure volvulus in a child with chronic idiopathic intestinal pseudo-obstruction syndrome. (16832673)
2006
16
Intestinal pseudo-obstruction as a manifestation of tumor necrosis factor receptor-associated periodic syndrome. (16865571)
2006
17
Intestinal pseudo-obstruction, lymphocytic leiomyositis and atrophy of the muscularis externa in a dog. (16844822)
2006
18
Primary intestinal autoimmune disease as a cause of chronic intestinal pseudo-obstruction. (16009699)
2005
19
Acute intestinal pseudo-obstruction (Ogilvie's syndrome). (20011348)
2005
20
Intestinal transplantation for chronic intestinal pseudo-obstruction in adult patients. (15084181)
2004
21
Chronic idiopathic intestinal pseudo-obstruction: the need for a multidisciplinary approach to management. (15373960)
2004
22
Chronic idiopathic intestinal pseudo-obstruction in an English bulldog. (11380018)
2001
23
Involvement of endogenous nitric oxide and c-kit-expressing cells in chronic intestinal pseudo-obstruction. (10770377)
2000
24
Anisakis simplex: a cause of intestinal pseudo-obstruction. (10799943)
2000
25
Acute Intestinal Pseudo-obstruction. (11096588)
2000
26
Pancreatic somatostatinoma presenting with chronic intestinal pseudo-obstruction syndrome. (17912215)
1996
27
Infantile chronic idiopathic intestinal pseudo-obstruction: the role of small intestinal manometry as a diagnostic tool and prognostic indicator. (8977348)
1996
28
Intestinal pseudo-obstruction, myasthenia gravis, and thymoma. (8857731)
1996
29
Chronic intestinal pseudo-obstruction. (7879688)
1995
30
Intestinal pseudo-obstruction and ischemia secondary to both beta 2-microglobulin and serum A amyloid deposition. (7675780)
1995
31
Capillariasis with chronic intestinal pseudo-obstruction. (7777934)
1994
32
Diffuse lymphoplasmacytic infiltration of the small intestine with damage to nerve plexus. A cause of intestinal pseudo-obstruction. (8343045)
1993
33
Intestinal pseudo-obstruction with deficient smooth muscle alpha-actin. (1468752)
1992
34
Erythromycin in chronic intestinal pseudo-obstruction. (2362109)
1990
35
Chronic intestinal pseudo-obstruction: progress and problems. (2303965)
1990
36
HIV infection and intestinal pseudo-obstruction. (2386626)
1990
37
Polyneuropathy, ophthalmoplegia, leukoencephalopathy, and intestinal pseudo-obstruction: POLIP syndrome. (2173474)
1990
38
Chronic intestinal pseudo-obstruction: diagnosis and treatment. (2642997)
1989
39
Intestinal pseudo-obstruction related to using verapamil. (2603423)
1989
40
Amitriptyline overdose complicated by intestinal pseudo-obstruction and caecal perforation. (2616439)
1989
41
Paraneoplastic intestinal pseudo-obstruction as the presenting feature of small-cell lung cancer. (2838368)
1988
42
Chronic intestinal pseudo-obstruction in two patients. Overlap of features of systemic sclerosis and visceral myopathy. (3397047)
1988
43
Alterations in cholinergic muscarinic and somatostatin binding sites in a patient with idiopathic intestinal pseudo-obstruction. (2905587)
1988
44
Intestinal pseudo-obstruction. (6846996)
1983
45
Chronic intestinal pseudo-obstruction. (6793659)
1981
46
Idiopathic intestinal pseudo-obstruction: a familial visceral neuropathy. (7438508)
1980
47
Natal teeth, patent ductus arteriosus and intestinal pseudo-obstruction: a lethal syndrome in the newborn. (1269170)
1976
48
Myxedema ileus. A form of intestinal pseudo-obstruction. (1242154)
1975
49
Proceedings: Colonic pseudo-obstruction complicating jejuno-ileal bypass: the role of intestinal flora. (1107172)
1975
50
Intestinal pseudo-obstruction. (4146635)
1972

Genetic Variations for Intestinal Pseudo-Obstruction

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Intestinal Pseudo-Obstruction:

62
id Symbol AA change Variation ID SNP ID
1CLMPp.Val124AspVAR_069713

Expression for genes affiliated with Intestinal Pseudo-Obstruction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intestinal Pseudo-Obstruction

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Pathways for genes affiliated with Intestinal Pseudo-Obstruction

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Compounds for genes affiliated with Intestinal Pseudo-Obstruction

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GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

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16Gene Ontology
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Cellular components related to Intestinal Pseudo-Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.1CLMP, FLNA

Products for genes affiliated with Intestinal Pseudo-Obstruction

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Sources for Intestinal Pseudo-Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet