IPO
MCID: INT072
MIFTS: 42

Intestinal Pseudo-Obstruction (IPO) malady

Gastrointestinal diseases, Neuronal diseases categories

Summaries for Intestinal Pseudo-Obstruction

About this section
Sources:
42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. it may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. the condition is sometimes inherited (in an x-linked recessive or autosomal dominant manner) and may be caused by mutations in the flna gene; it may also be acquired after certain illnesses. the goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. last updated: 5/10/2011

MalaCards: Intestinal Pseudo-Obstruction, also known as congenital short bowel syndrome, is related to paralytic ileus and systemic lupus erythematosus. An important gene associated with Intestinal Pseudo-Obstruction is FLNA (filamin A, alpha). Affiliated tissues include small intestine, liver and smooth muscle.

Genetics Home Reference:21 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia:63 Intestinal Pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Description from OMIM:46 615237,300048

Aliases & Classifications for Intestinal Pseudo-Obstruction

About this section
Sources:
21Genetics Home Reference, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 46OMIM, 34MeSH, 39NCIt, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Neuronal diseases


Aliases & Descriptions:

intestinal pseudo-obstruction 8 42 21 10 44 60
congenital short bowel syndrome 21 46
hollow visceral myopathy 42 60
paralytic ileus 21 60
congenital idiopathic intestinal pseudoobstruction 60
chronic idiopathic intestinal pseudo-obstruction 21
pseudo-obstruction of gastrointestinal tract 60
pseudointestinal obstruction syndrome 21
pseudo-obstruction of intestine 8
intestinal pseudoobstruction 42
intestine pseudoobstruction 8
pseudoobstructive syndrome 21
enteric neuropathy 21
ciip 21
ipo 21


External Ids:

Disease Ontology8 DOID:3878
MeSH34 D007418
SNOMED-CT56 235825006
NCIt39 C34733

Related Diseases for Intestinal Pseudo-Obstruction

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Intestinal Pseudo-Obstruction family:

Intestinal Obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1paralytic ileus11.2
2systemic lupus erythematosus10.7
3lupus erythematosus10.7
4short bowel syndrome10.6
5myopathy10.6
6amyloidosis10.6
7neuronitis10.5
8colonic pseudo-obstruction10.5
9thymoma10.5
10intestinal pseudoobstruction neuronal chronic idiopathic x-linked10.5
11natal teeth, intestinal pseudoobstruction and patent ductus10.5
12appendicitis10.5
13myasthenia gravis10.4
14strongyloidiasis10.4
15kawasaki disease10.4
16myotonic dystrophy10.4
17hypothyroidism10.3
18small cell carcinoma10.3
19gastroparesis10.3
20pneumatosis cystoides intestinalis10.3
21diarrhea10.3
22intestinal perforation10.3
23lung small cell carcinoma10.3
24multiple sclerosis10.3
25ophthalmoplegia10.3
26pheochromocytoma10.3
27acute pancreatitis10.3
28schizophrenia10.3
29megaduodenum and/or megacystis10.3
30ganglioneuroblastoma10.2
31hydrocephalus with congenital idiopathic intestinal pseudoobstruction10.2
32myopathic intestinal pseudoobstruction10.2
33unclassified intestinal pseudoobstruction10.2
34parkinson's disease10.1
35neurofibromatosis10.1
36alcohol abuse10.1
37myelitis10.1
38acute diarrhea10.1
39hemophagocytic lymphohistiocytosis10.1
40proctitis10.1
41somatostatinoma10.1
42pancreatic somatostatinoma10.1
43mixed connective tissue disease10.1
44hypoparathyroidism10.1
45achalasia10.1
46neurogenic bladder10.1
47adult spinal muscular atrophy10.1
48capillariasis10.1
49multiple mucosal neuroma10.1
50myxedema10.1

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Clinical Features for Intestinal Pseudo-Obstruction

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

615237,300048

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intestinal Pseudo-Obstruction

Drug clinical trials:

Search ClinicalTrials for Intestinal Pseudo-Obstruction

Search NIH Clinical Center for Intestinal Pseudo-Obstruction

Search CenterWatch for Intestinal Pseudo-Obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

About this section

Anatomical Context for Intestinal Pseudo-Obstruction

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

32
Small intestine, Liver, Smooth muscle, Colon, Lung, Lymph node

Animal Models for Intestinal Pseudo-Obstruction or affiliated genes

About this section

Publications for Intestinal Pseudo-Obstruction

About this section
Sources:
50PubMed
See all sources

Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 414)
idTitleAuthorsYear
1
Occurrence of Intestinal Pseudo-obstruction in a Brainstem Hemorrhage Patient. (22639755)
2012
2
A novel approach to paraneoplastic intestinal pseudo-obstruction. (22072051)
2012
3
An interesting case of intestinal pseudo-obstruction: MNGIE. (21922881)
2011
4
Chronic intestinal pseudo-obstruction: clinical features, diagnosis, and therapy. (22100118)
2011
5
Normal oxidative phosphorylation in intestinal smooth muscle of childhood chronic intestinal pseudo-obstruction. (20879992)
2011
6
Polymorphisms of the RET gene in hirschsprung disease, anorectal malformation and intestinal pseudo-obstruction in Taiwan. (20123584)
2010
7
Chronic idiopathic intestinal pseudo-obstruction treated by near total small bowel resection: a 20-year experience. (20872085)
2010
8
Clinical features and long-term survival in chronic intestinal pseudo-obstruction and enteric dysmotility. (19308797)
2009
9
Chronic idiopathic intestinal pseudo-obstruction: a case report and discussion. (19777978)
2009
10
Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis. (18955007)
2008
11
Acute intestinal pseudo-obstruction after induction treatment of relapsed acute promyelocytic leukemia with arsenic trioxide. (17635008)
2008
12
Intestinal pseudo-obstruction and pneumatosis cystoides intestinalis in a scleroderma patient. (17617347)
2007
13
Severe delayed complication after percutaneous endoscopic colostomy for chronic intestinal pseudo-obstruction: a case report and review of the literature. (17465514)
2007
14
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
15
Semiquantitative assessment of the intestinal motility in chronic intestinal pseudo-obstruction in systemic sclerosis and mixed connective tissue disease by Sitzmarks capsule. (17039319)
2006
16
Intestinal pseudo-obstruction as the initial presentation of systemic lupus erythematosus: the need for enteroscopic evaluation. (16301053)
2005
17
Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction. (16291166)
2005
18
Thymoma-associated neuromyotonia with antibodies against voltage-gated potassium channels presenting as chronic intestinal pseudo-obstruction. (15753614)
2005
19
Pneumatosis cystoides intestinalis in primary intestinal pseudo-obstruction: a nonsurgical cause of pneumoperitoneum. (16271330)
2005
20
Massive hemorrhage and pseudo-obstruction of the small intestine caused by primary AL amyloidosis associated with gastric cancer: report of a case. (15449160)
2004
21
Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction. (15479666)
2004
22
Role of electrogastrography in detecting motility disorders in children affected by chronic intestinal pseudo-obstruction and Crohn's disease. (12664412)
2003
23
Intestinal pseudo-obstruction in a diabetic man: role of the mitochondrial A3243G mutation. (12379086)
2002
24
Quality of life outcomes in congenital chronic intestinal pseudo-obstruction. (12353838)
2002
25
Intravenous immunoglobulins and octreotide as treatment of intestinal pseudo-obstruction revealing a recurrence of polymyositis. (11561127)
2001
26
Chronic Idiopathic Intestinal Pseudo-obstruction. (11096594)
2000
27
Fludarabine induced intestinal pseudo-obstruction: case report and literature review. (10912495)
2000
28
Intestinal pseudo-obstruction associated with oral morphine. (9650001)
1998
29
Case report: Small intestinal pseudo-obstruction: an unusual manifestation of polymyositis. (9766728)
1998
30
Desmin-rich smooth muscle bundles in chronic intestinal pseudo-obstruction. (9327377)
1997
31
Intestinal pseudo-obstruction as an initial presentation of systemic sclerosis in two children. (9133948)
1997
32
Chronic intestinal pseudo-obstruction: a cause of intestinal failure. (8029976)
1994
33
Acute intestinal pseudo-obstruction due to malignant thymoma. (8266165)
1993
34
Autonomic dysfunction in patients with chronic intestinal pseudo-obstruction. (8324379)
1993
35
Intestinal pseudo-obstruction due to amyloidosis of the colon in association with an intestinal plasmacytoma. (1800969)
1991
36
Equine myenteric ganglionitis: a case of chronic intestinal pseudo-obstruction. (2403425)
1990
37
Fatal intestinal pseudo-obstruction in brown bowel syndrome. (2294870)
1990
38
Chronic intestinal pseudo-obstruction. (2747296)
1989
39
Surgical management of chronic intestinal pseudo-obstruction in infancy and childhood. (2513608)
1989
40
Antroduodenal motility in children with chronic intestinal pseudo-obstruction. (3373394)
1988
41
Coeliac disease presenting with intestinal pseudo-obstruction. (18668867)
1985
42
Chronic intestinal pseudo-obstruction. (6951328)
1982
43
Cancer and intestinal pseudo-obstruction. (6895982)
1982
44
Disorganised electrical activity in a child with idiopathic intestinal pseudo-obstruction. (6893974)
1981
45
Recurrent or chronic intestinal pseudo-obstruction. (7249382)
1981
46
Idiopathic intestinal pseudo-obstruction. Report of a case with neuropathological studies. (687249)
1978
47
Prostaglandins and acute intestinal pseudo-obstruction. (69218)
1977
48
Idiopathic intestinal pseudo-obstruction. (1130391)
1975
49
Hypoparathyroidism: a review of the literature and report of two cases in sisters, one with steatorrhea and intestinal pseudo-obstruction. (13919902)
1962
50
Intestinal pseudo-obstruction. (13514744)
1958

Genetic Variations for Intestinal Pseudo-Obstruction

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Intestinal Pseudo-Obstruction:

62
id Symbol AA change Variation ID SNP ID
1CLMPp.Val124AspVAR_069713

Expression for genes affiliated with Intestinal Pseudo-Obstruction

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intestinal Pseudo-Obstruction

Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for genes affiliated with Intestinal Pseudo-Obstruction

About this section

Compounds for genes affiliated with Intestinal Pseudo-Obstruction

About this section

GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Intestinal Pseudo-Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.1CLMP, FLNA

Products for genes affiliated with Intestinal Pseudo-Obstruction

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intestinal Pseudo-Obstruction

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet