MCID: INT072
MIFTS: 44

Intestinal Pseudo-Obstruction malady

Rare diseases, Gastrointestinal diseases, Neuronal diseases, Fetal diseases categories

Summaries for Intestinal Pseudo-Obstruction

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NIH Rare Diseases:41 Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. it may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. the condition is sometimes inherited (in an x-linked recessive or autosomal dominant manner) and may be caused by mutations in the flna gene; it may also be acquired after certain illnesses. the goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. last updated: 5/10/2011

MalaCards based summary: Intestinal Pseudo-Obstruction, also known as hollow visceral myopathy, is related to short bowel syndrome and paralytic ileus. An important gene associated with Intestinal Pseudo-Obstruction is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways is TCR signaling in naive CD4+ T cells. The compounds nitroglycerin and carboplatin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, small intestine and colon, and related mouse phenotypes are respiratory system and digestive/alimentary.

Genetics Home Reference:21 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia:63 Intestinal Pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Aliases & Classifications for Intestinal Pseudo-Obstruction

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Intestinal Pseudo-Obstruction, Aliases & Descriptions:

Name: Intestinal Pseudo-Obstruction 9 41 21 11 43 60
Hollow Visceral Myopathy 41 60
Paralytic Ileus 21 60
Congenital Idiopathic Intestinal Pseudoobstruction 60
Chronic Idiopathic Intestinal Pseudo-Obstruction 21
Pseudointestinal Obstruction Syndrome 21
Pseudo-Obstruction of Intestine 9
 
Congenital Short Bowel Syndrome 21
Intestinal Pseudoobstruction 41
Intestine Pseudoobstruction 9
Pseudoobstructive Syndrome 21
Enteric Neuropathy 21
Ciip 21
Ipo 21


Classifications:



External Ids:

Disease Ontology9 DOID:3878
NCIt38 C34733
SNOMED-CT55 235825006
MeSH33 D007418

Related Diseases for Intestinal Pseudo-Obstruction

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Diseases in the Intestinal Obstruction family:

intestinal pseudo-obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1short bowel syndrome31.4SST
2paralytic ileus11.3
3systemic lupus erythematosus10.8
4lupus erythematosus10.8
5myopathy10.7
6neuropathy10.6
7amyloidosis10.6
8neuronitis10.6
9thymoma10.6
10natal teeth, intestinal pseudoobstruction and patent ductus10.6
11visceral myopathy10.6
12peritonitis10.6
13appendicitis10.5
14intestinal pseudoobstruction, neuronal10.5
15myasthenia gravis10.5
16strongyloidiasis10.5
17kawasaki disease10.4
18pancreatitis10.4
19myotonic dystrophy10.4
20polymyositis10.4
21ileus10.4
22hypothyroidism10.4
23myopathic intestinal pseudoobstruction10.4
24unclassified intestinal pseudoobstruction10.4
25mungan syndrome10.3
26pheochromocytoma10.3
27crohn's disease10.3
28gastroparesis10.3
29small cell carcinoma10.3
30patent ductus arteriosus10.3
31pneumatosis cystoides intestinalis10.3
32constipation10.3
33diarrhea10.3
34ophthalmoplegia10.3
35scleroderma10.3
36mitochondrial neurogastrointestinal encephalopathy disease10.3
37autonomic dysfunction10.3
38schizophrenia10.3
39acute pancreatitis10.3
40portal vein thrombosis10.3
41ganglioneuroblastoma10.3
42visceral neuropathy familial10.3
43congenital short bowel syndrome10.2
44meconium ileus10.2
45retinoblastoma10.2
46lung cancer10.2
47mitochondrial recessive ataxia syndrome10.2
48mucopolysaccharidosis ii10.2
49alcohol abuse10.2
50hemophagocytic lymphohistiocytosis10.2

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Symptoms for Intestinal Pseudo-Obstruction

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Drugs & Therapeutics for Intestinal Pseudo-Obstruction

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Drug clinical trials:

Search ClinicalTrials for Intestinal Pseudo-Obstruction

Search NIH Clinical Center for Intestinal Pseudo-Obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

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Anatomical Context for Intestinal Pseudo-Obstruction

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MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

31
Smooth muscle, Small intestine, Colon, Liver, Lung, Lymph node

Animal Models for Intestinal Pseudo-Obstruction or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7SOX10, FLNA, ACHE
2MP:00053818.4B2M, SOX10, FLNA, SST
3MP:00053828.4FLNA, ACHE, SOX10
4MP:00053868.0SOX10, ACHE, SST, FLNA
5MP:00036317.7B2M, SOX10, FLNA, SST, ACHE
6MP:00053787.6ACHE, FLNA, SST, B2M, SOX10
7MP:00053767.5B2M, SOX10, FLNA, SST, ACHE

Publications for Intestinal Pseudo-Obstruction

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Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
Advancement in the clinical management of intestinal pseudo-obstruction. (25020006)
2014
2
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. (24177421)
2013
3
Transgastric long tube placement following percutaneous endoscopic gastrostomy for severe chronic intestinal pseudo-obstruction related to systemic sclerosis. (24252025)
2013
4
Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction. (23018539)
2012
5
Retraction of article. Eugen Florin Georgescu, Ion Vasile, Ana Claudia Georgescu. Intestinal pseudo-obstruction--a rare condition with heterogeneous etiology and unpredictable outcome. A case report. J Gastrointestin Liver Dis. March 2008; 17(1): 77-80. (22720315)
2012
6
Raising awareness about chronic intestinal pseudo-obstruction (CIPO): a case report showing CIPO as initial manifestation of atypical seronegative systemic sclerosis. (23059804)
2012
7
Prognostic yield of esophageal manometry in chronic intestinal pseudo-obstruction: a retrospective cohort of 116 adult patients. (22762287)
2012
8
An interesting case of intestinal pseudo-obstruction: MNGIE. (21922881)
2011
9
Major gastrointestinal manifestations in lupus patients in Asia: lupus enteritis, intestinal pseudo-obstruction, and protein-losing gastroenteropathy. (20947549)
2010
10
Chronic intestinal pseudo-obstruction related to viral infections. (20172270)
2010
11
Frequency of mitochondrial defects in patients with chronic intestinal pseudo-obstruction. (19344718)
2009
12
Intestinal pseudo-obstruction associated with polymyositis successfully treated with somatostatin analog]. (18323156)
2008
13
Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis. (18955007)
2008
14
Chronic intestinal pseudo-obstruction caused by an intestinal inflammatory myopathy: case report and review of the literature. (18004985)
2008
15
Fibrosing gastrointestinal leiomyositis as a cause of chronic intestinal pseudo-obstruction in an 8-month-old dog. (17197634)
2007
16
Chronic intestinal pseudo-obstruction due to buserelin-induced formation of anti-GnRH antibodies. (17241858)
2007
17
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
18
Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction. (16329126)
2006
19
Semiquantitative assessment of the intestinal motility in chronic intestinal pseudo-obstruction in systemic sclerosis and mixed connective tissue disease by Sitzmarks capsule. (17039319)
2006
20
Acute on chronic intestinal pseudo-obstruction as a cause of death in a previously healthy twenty-year-old male. (16614983)
2006
21
Does bcl2 immunostaining really help with pathological evaluation of intestinal pseudo-obstruction? (16861987)
2006
22
Caecal impaction and chronic intestinal pseudo-obstruction in a dog. (15703010)
2005
23
Multivisceral transplantation for pediatric intestinal pseudo-obstruction: single center's experience of 16 cases. (15050142)
2004
24
Prokinetics in the treatment of acute intestinal pseudo-obstruction. (15057661)
2004
25
Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice. (14598259)
2003
26
SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism. (12189494)
2002
27
Rare presentation of intestinal amyloidosis with acute intestinal pseudo-obstruction and perforation. (12401832)
2002
28
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy. (10981652)
2000
29
Intestinal pseudo-obstruction due to neurofibromatosis responding to cisapride. (10812823)
2000
30
Chronic intestinal pseudo-obstruction: treatment and long term follow up of 44 patients. (10373127)
1999
31
Eosinophilic enterocolitis and visceral neuropathy with chronic intestinal pseudo-obstruction. (10372941)
1999
32
Myasthenia gravis, thymoma, intestinal pseudo-obstruction, and neuronal nicotinic acetylcholine receptor antibody. (10514242)
1999
33
Autonomic dysfunction in chronic intestinal pseudo-obstruction. (9869551)
1998
34
Desmin-rich smooth muscle bundles in chronic intestinal pseudo-obstruction. (9327377)
1997
35
Clinical characteristics of chronic idiopathic intestinal pseudo-obstruction in adults. (9414977)
1997
36
Manometric evaluation of gastrointestinal motility in children with chronic intestinal pseudo-obstruction syndrome. (8938348)
1996
37
Pancreatic somatostatinoma presenting with chronic intestinal pseudo-obstruction syndrome. (17912215)
1996
38
Small bowel resection for relief of chronic intestinal pseudo-obstruction. (7541935)
1995
39
Acute intestinal pseudo-obstruction due to malignant thymoma. (8266165)
1993
40
Erythromycin in chronic intestinal pseudo-obstruction. (2362109)
1990
41
Chronic intestinal pseudo-obstruction: progress and problems. (2303965)
1990
42
Chronic intestinal pseudo-obstruction: diagnosis and treatment. (2642997)
1989
43
Intestinal pseudo-obstruction due to dialysis amyloidosis. (2612073)
1989
44
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. (6688501)
1983
45
Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. A paraneoplastic neuropathy of the gastrointestinal tract. (6297344)
1983
46
Radiation-induced recurrent intestinal pseudo-obstruction. (6895001)
1981
47
Chronic intestinal pseudo-obstruction. A report of 27 cases and review of the literature. (6894476)
1981
48
Idiopathic intestinal pseudo-obstruction: a familial visceral neuropathy. (7438508)
1980
49
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979
50
Myxedema ileus. A form of intestinal pseudo-obstruction. (1242154)
1975

Variations for Intestinal Pseudo-Obstruction

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Expression for genes affiliated with Intestinal Pseudo-Obstruction

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Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for genes affiliated with Intestinal Pseudo-Obstruction

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Pathways related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCR signaling in naive CD8+ T cells36
9.4FLNA, B2M

Compounds for genes affiliated with Intestinal Pseudo-Obstruction

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Compounds related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1nitroglycerin43 1210.6B2M, SST
2carboplatin43 49 1211.5SOX10, SST
3captopril43 59 49 28 1213.5SST, B2M
4sodium nitroprusside439.4SST, B2M
5nifedipine43 28 49 1212.4SST, B2M
6cyclophosphamide43 49 1211.3SST, B2M
7pyridostigmine43 1210.3ACHE, SST
8pirenzepine43 28 1211.3ACHE, SST
9atropine43 28 1211.2ACHE, SST
10carbachol43 28 1211.0SST, ACHE
11thyroxine43 2410.0SST, B2M
12choline43 24 1210.9ACHE, SST
13dopamine43 28 24 1211.8ACHE, SST, FLNA

GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

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Cellular components related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.1ACHE, B2M
2extracellular spaceGO:00056158.2ACHE, SST, B2M
3extracellular regionGO:00055767.9ACHE, SST, FLNA, B2M

Products for genes affiliated with Intestinal Pseudo-Obstruction

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Sources for Intestinal Pseudo-Obstruction

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25ICD10
26ICD10 via Orphanet
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29KEGG
33MeSH
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38NCIt
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51QIAGEN
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