MCID: INT072
MIFTS: 46

Intestinal Pseudo-Obstruction malady

Categories: Rare diseases, Gastrointestinal diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Intestinal Pseudo-Obstruction

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Aliases & Descriptions for Intestinal Pseudo-Obstruction:

Name: Intestinal Pseudo-Obstruction 11 47 25 26 49 38 13 67
Hollow Visceral Myopathy 47 67
Paralytic Ileus 25 67
Congenital Idiopathic Intestinal Pseudoobstruction 67
Chronic Idiopathic Intestinal Pseudo-Obstruction 25
Pseudointestinal Obstruction Syndrome 25
Congenital Short Bowel Syndrome 25
 
Pseudo-Obstruction of Intestine 11
Intestinal Pseudoobstruction 47
Intestine Pseudoobstruction 11
Pseudoobstructive Syndrome 25
Enteric Neuropathy 25
Ciip 25
Ipo 25

Classifications:



External Ids:

Disease Ontology11 DOID:3878
MeSH38 D007418
SNOMED-CT61 235825006
NCIt44 C34733

Summaries for Intestinal Pseudo-Obstruction

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Genetics Home Reference:25 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

MalaCards based summary: Intestinal Pseudo-Obstruction, also known as hollow visceral myopathy, is related to paralytic ileus and intestinal pseudoobstruction, neuronal, and has symptoms including constipation, constipation and genitourinary symptoms. An important gene associated with Intestinal Pseudo-Obstruction is TYMP (Thymidine Phosphorylase), and among its related pathways is Smooth Muscle Contraction. Affiliated tissues include smooth muscle, small intestine and colon, and related mouse phenotypes are digestive/alimentary and respiratory system.

Wikipedia:70 Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Related Diseases for Intestinal Pseudo-Obstruction

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Diseases in the Intestinal Obstruction family:

intestinal pseudo-obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1paralytic ileus12.5
2intestinal pseudoobstruction, neuronal11.9
3visceral myopathy11.5
4chronic atrial and intestinal dysrhythmia11.4
5mitochondrial neurogastrointestinal encephalopathy disease11.3
6chronic intestinal pseudoobstruction11.3
7congenital short bowel syndrome11.1
8mungan syndrome11.1
9colonic pseudo-obstruction11.1
10systemic lupus erythematosus10.4
11lupus erythematosus10.4
12jejunal atresia10.3ACTG2, MYH11
13myopathy10.3
14sparganosis10.2FLNA, MT-TL1
15hirschsprung nail hypoplasia dysmorphism10.2EDNRB, SOX10
16ulceration of vulva10.2MT-TL1, TYMP
17conjunctival cancer10.2EDNRB, SOX10
18neuropathy10.2
19peritonitis10.2
20amyloidosis10.2
21thymoma10.1
22neuronitis10.1
23pulmonary immaturity10.1SOX10, SYP
24kawasaki disease10.0
25myasthenia gravis10.0
26pancreatitis9.9
27myotonic dystrophy9.9
28polymyositis9.9
29encephalopathy9.9
30pheochromocytoma9.9
31crohn's disease9.9
32small cell carcinoma9.9
33gastroparesis9.9
34pneumatosis cystoides intestinalis9.9
35diarrhea9.9
36patent ductus arteriosus9.9
37constipation9.9
38autonomic dysfunction9.9
39soft palate cancer9.8FLNA, RET
40hypogonadism cardiomyopathy9.8RET, SYP
41central hypoventilation syndrome, congenital9.8EDNRB, RET
42multiple endocrine neoplasia iib9.8EDNRB, RET
43papillary thymic adenocarcinoma9.7RET, SYP
44lung combined type small cell carcinoma9.7RET, SYP
45lung cancer9.7
46ellis-van creveld syndrome9.7
47meconium ileus9.7
48retinoblastoma9.7
49mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes9.7
50neuronal intranuclear inclusion disease9.7

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Symptoms for Intestinal Pseudo-Obstruction

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UMLS symptoms related to Intestinal Pseudo-Obstruction:


constipation, genitourinary symptoms, vomiting

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

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Drugs for Intestinal Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ColaNutraceuticalPhase 3, Phase 21881
2Pharmaceutical SolutionsPhase 27793

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean SectionCompletedNCT01131416Phase 2, Phase 3
2Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or SurgeryCompletedNCT00140868Phase 3
3Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001)CompletedNCT01553591Phase 3
4Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3002)CompletedNCT01553747Phase 3
5Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian CancerWithdrawnNCT01389986Phase 2, Phase 3
6Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After PancreaticoduodenectomyUnknown statusNCT01607307Phase 2
7Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP)CompletedNCT00793247Phase 2
8Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With DiarrheaCompletedNCT01130272Phase 2
9Acupuncture to Prevent Postoperative Bowel Paralysis (Paralytic Ileus)SuspendedNCT00065234Phase 2
10Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstructionRecruitingNCT02731183Phase 1
11Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-upCompletedNCT00213460
12Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure PatientsRecruitingNCT02561819
13Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in InfantsTerminatedNCT01062815

Search NIH Clinical Center for Intestinal Pseudo-Obstruction


Cochrane evidence based reviews: intestinal pseudo-obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

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Genetic tests related to Intestinal Pseudo-Obstruction:

id Genetic test Affiliating Genes
1 Intestinal Pseudo-Obstruction26

Anatomical Context for Intestinal Pseudo-Obstruction

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MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

35
Smooth muscle, Small intestine, Colon, Lung, Liver, Lymph node

Animal Models for Intestinal Pseudo-Obstruction or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7EDNRB, FLNA, MYH11, RET, SOX10
2MP:00053887.9EDNRB, FLNA, MYH11, RET, SOX10
3MP:00053847.8EDNRB, FLNA, L1CAM, MYH11, RET, SOX10
4MP:00036317.5EDNRB, FLNA, L1CAM, RET, SOX10, SYP

Publications for Intestinal Pseudo-Obstruction

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Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 453)
idTitleAuthorsYear
1
Chronic intestinal pseudo-obstruction: An unusual presentation. (27852553)
2016
2
Smooth-Muscle Myopathy in Systemic Lupus Erythematosus Presenting With Intestinal Pseudo-Obstruction. (27694873)
2016
3
Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review. (26078585)
2015
4
Kawasaki's disease: an often overlooked cause of intestinal pseudo-obstruction in children. (26386569)
2015
5
Mutations in RAD21 Disrupt Regulation of APOB in Patients With Chronic Intestinal Pseudo-Obstruction. (25575569)
2015
6
Advancement in the clinical management of intestinal pseudo-obstruction. (25020006)
2014
7
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. (24177421)
2013
8
Intestinal pseudo-obstruction due to small bowel I+-actin deficiency in a child with Ehlers-Danlos syndrome. (23963838)
2013
9
Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction. (23018539)
2012
10
Retraction of article. Eugen Florin Georgescu, Ion Vasile, Ana Claudia Georgescu. Intestinal pseudo-obstruction--a rare condition with heterogeneous etiology and unpredictable outcome. A case report. J Gastrointestin Liver Dis. March 2008; 17(1): 77-80. (22720315)
2012
11
Hemophagocytic lymphohistiocytosis with multiorgan involvement in children with chronic intestinal pseudo-obstruction receiving parenteral nutrition support. (21866056)
2012
12
Major gastrointestinal manifestations in lupus patients in Asia: lupus enteritis, intestinal pseudo-obstruction, and protein-losing gastroenteropathy. (20947549)
2010
13
Frequency of mitochondrial defects in patients with chronic intestinal pseudo-obstruction. (19344718)
2009
14
Clinical features and long-term survival in chronic intestinal pseudo-obstruction and enteric dysmotility. (19308797)
2009
15
Intestinal pseudo-obstruction associated with polymyositis successfully treated with somatostatin analog]. (18323156)
2008
16
Chronic intestinal pseudo-obstruction caused by an intestinal inflammatory myopathy: case report and review of the literature. (18004985)
2008
17
Intestinal pseudo-obstruction: an uncommon condition with heterogeneous etiology and unpredictable outcome. (18240359)
2008
18
Intestinal pseudo-obstruction in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) associated with phenytoin therapy. (18226864)
2008
19
Chronic intestinal pseudo-obstruction due to buserelin-induced formation of anti-GnRH antibodies. (17241858)
2007
20
Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction. (16329126)
2006
21
Semiquantitative assessment of the intestinal motility in chronic intestinal pseudo-obstruction in systemic sclerosis and mixed connective tissue disease by Sitzmarks capsule. (17039319)
2006
22
Does bcl2 immunostaining really help with pathological evaluation of intestinal pseudo-obstruction? (16861987)
2006
23
Caecal impaction and chronic intestinal pseudo-obstruction in a dog. (15703010)
2005
24
Surgery in intestinal pseudo-obstruction: pro. (16131976)
2005
25
Intestinal pseudo-obstruction as the initial presentation of systemic lupus erythematosus: the need for enteroscopic evaluation. (16301053)
2005
26
Multivisceral transplantation for pediatric intestinal pseudo-obstruction: single center's experience of 16 cases. (15050142)
2004
27
Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice. (14598259)
2003
28
Surgical treatment of chronic intestinal pseudo-obstruction: report of three cases. (12560910)
2003
29
Intestinal pseudo-obstruction and urinary retention: cardinal features of a mitochondrial DNA-related disease. (12603507)
2003
30
SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism. (12189494)
2002
31
Intestinal pseudo-obstruction in a diabetic man: role of the mitochondrial A3243G mutation. (12379086)
2002
32
Discriminating pediatric condition falsification from chronic intestinal pseudo-obstruction in toddlers. (12020069)
2002
33
Intestinal pseudo-obstruction due to neurofibromatosis responding to cisapride. (10812823)
2000
34
Involvement of endogenous nitric oxide and c-kit-expressing cells in chronic intestinal pseudo-obstruction. (10770377)
2000
35
Myasthenia gravis, thymoma, intestinal pseudo-obstruction, and neuronal nicotinic acetylcholine receptor antibody. (10514242)
1999
36
Desmin-rich smooth muscle bundles in chronic intestinal pseudo-obstruction. (9327377)
1997
37
Clinical heterogeneity of chronic intestinal pseudo-obstruction. (9142309)
1997
38
Manometric evaluation of gastrointestinal motility in children with chronic intestinal pseudo-obstruction syndrome. (8938348)
1996
39
Pancreatic somatostatinoma presenting with chronic intestinal pseudo-obstruction syndrome. (17912215)
1996
40
Chronic intestinal pseudo-obstruction in a dog. (8198514)
1994
41
Acute intestinal pseudo-obstruction due to malignant thymoma. (8266165)
1993
42
Chronic intestinal pseudo-obstruction: progress and problems. (2303965)
1990
43
HIV infection and intestinal pseudo-obstruction. (2386626)
1990
44
Jejunal water and sodium secretion occurs in chronic idiopathic intestinal pseudo-obstruction. (2324480)
1990
45
Chronic intestinal pseudo-obstruction: diagnosis and treatment. (2642997)
1989
46
Intestinal pseudo-obstruction due to dialysis amyloidosis. (2612073)
1989
47
Coeliac disease presenting with intestinal pseudo-obstruction. (3838962)
1985
48
Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. A paraneoplastic neuropathy of the gastrointestinal tract. (6297344)
1983
49
Idiopathic intestinal pseudo-obstruction: a familial visceral neuropathy. (7438508)
1980
50
Idiopathic intestinal pseudo-obstruction. (1130391)
1975

Variations for Intestinal Pseudo-Obstruction

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Expression for genes affiliated with Intestinal Pseudo-Obstruction

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Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for genes affiliated with Intestinal Pseudo-Obstruction

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Pathways related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8ACTG2, MYH11

GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

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Cellular components related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:00329829.8ACTG2, MYH11

Biological processes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1melanocyte differentiationGO:003031810.0EDNRB, SOX10
2peripheral nervous system developmentGO:000742210.0EDNRB, SOX10
3posterior midgut developmentGO:00074979.7EDNRB, RET
4response to painGO:00482659.5EDNRB, RET
5enteric nervous system developmentGO:00484849.2EDNRB, RET, SOX10
6neural crest cell migrationGO:00017559.1EDNRB, RET, SOX10
7nervous system developmentGO:00073998.5EDNRB, L1CAM, RET

Sources for Intestinal Pseudo-Obstruction

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet