MCID: INT072
MIFTS: 45

Intestinal Pseudo-Obstruction malady

Categories: Rare diseases, Gastrointestinal diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Intestinal Pseudo-Obstruction

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Aliases & Descriptions for Intestinal Pseudo-Obstruction:

Name: Intestinal Pseudo-Obstruction 10 45 23 47 12 36 65
Hollow Visceral Myopathy 45 65
Paralytic Ileus 23 65
Congenital Idiopathic Intestinal Pseudoobstruction 65
Chronic Idiopathic Intestinal Pseudo-Obstruction 23
Pseudointestinal Obstruction Syndrome 23
Congenital Short Bowel Syndrome 23
 
Pseudo-Obstruction of Intestine 10
Intestinal Pseudoobstruction 45
Intestine Pseudoobstruction 10
Pseudoobstructive Syndrome 23
Enteric Neuropathy 23
Ciip 23
Ipo 23

Classifications:



External Ids:

Disease Ontology10 DOID:3878
MeSH36 D007418
SNOMED-CT59 235825006
NCIt42 C34733
UMLS65 C0021847, C0400874, C2746068

Summaries for Intestinal Pseudo-Obstruction

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NIH Rare Diseases:45 Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. it may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. the condition is sometimes inherited (in an x-linked recessive or autosomal dominant manner) and may be caused by mutations in the flna gene; it may also be acquired after certain illnesses. the goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. last updated: 4/1/2015

MalaCards based summary: Intestinal Pseudo-Obstruction, also known as hollow visceral myopathy, is related to paralytic ileus and chronic intestinal pseudoobstruction, and has symptoms including vomiting, genitourinary symptoms and constipation. An important gene associated with Intestinal Pseudo-Obstruction is TYMP (Thymidine Phosphorylase). Affiliated tissues include heart, t cells and brain, and related mouse phenotypes are pigmentation and skeleton.

Genetics Home Reference:23 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia:68 Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Related Diseases for Intestinal Pseudo-Obstruction

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Diseases in the Intestinal Obstruction family:

intestinal pseudo-obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1paralytic ileus12.6
2chronic intestinal pseudoobstruction11.7
3intestinal pseudoobstruction, neuronal11.6
4visceral myopathy11.6
5mitochondrial neurogastrointestinal encephalopathy disease11.4
6congenital short bowel syndrome11.3
7chronic atrial and intestinal dysrhythmia10.5
8systemic lupus erythematosus10.5
9lupus erythematosus10.5
10conjunctival intraepithelial neoplasm10.4EDN3, SOX10
11myopathy10.4
12neuropathy10.3
13alcoholic cardiomyopathy10.3ATXN7, TYMP
14amyloidosis10.3
15multiminicore disease10.3POLG, TYMP
16hyperostosis cranialis interna10.3POLG, TYMP
17thymoma10.3
18neuronitis10.3
19mitochondrial recessive ataxia syndrome10.2POLG, TYMP
20idiopathic juvenile osteoporosis10.2POLG, TYMP
21mungan syndrome10.2
22colonic pseudo-obstruction10.2
23autoimmune gastrointestinal dysmotility10.2
24blind loop syndrome10.2FLNA, SST
25hallucinogen abuse10.2POLG, TYMP
26pancreatic cystadenocarcinoma10.2PRSS1, SST
27myasthenia gravis10.1
28chronic tubotympanic suppurative otitis media10.1L1CAM, POLG
29kawasaki disease10.1
30pancreatitis10.1
31myotonic dystrophy10.1
32polymyositis10.1
33encephalopathy10.1
34pyloric stenosis10.0RET, TYMP
35hepatic flexure cancer10.0PRSS1, SST
36gallbladder disease10.0POLG, TYMP
37pheochromocytoma10.0
38crohn's disease10.0
39small cell carcinoma10.0
40gastroparesis10.0
41pneumatosis cystoides intestinalis10.0
42diarrhea10.0
43patent ductus arteriosus10.0
44constipation10.0
45ophthalmoplegia10.0
46autonomic dysfunction10.0
47cheek mucosa cancer9.9POLG, SOX10, TYMP
48shprintzen-goldberg syndrome9.9EDN3, RET
49hirschsprung disease 19.8EDN3, RET
50lung cancer9.8

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Symptoms for Intestinal Pseudo-Obstruction

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UMLS symptoms related to Intestinal Pseudo-Obstruction:


vomiting, genitourinary symptoms, constipation

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

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Drugs for Intestinal Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ColaNutraceuticalPhase 3, Phase 21768
2Pharmaceutical SolutionsPhase 27004

Interventional clinical trials:

idNameStatusNCT IDPhase
1Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or SurgeryCompletedNCT00140868Phase 3
2Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001)CompletedNCT01553591Phase 3
3Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3002)CompletedNCT01553747Phase 3
4Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP)CompletedNCT00793247Phase 2
5Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With DiarrheaCompletedNCT01130272Phase 2
6Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After PancreaticoduodenectomyActive, not recruitingNCT01607307Phase 2
7Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstructionRecruitingNCT02731183Phase 1
8Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-upCompletedNCT00213460
9Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure PatientsNot yet recruitingNCT02561819
10Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in InfantsTerminatedNCT01062815

Search NIH Clinical Center for Intestinal Pseudo-Obstruction


Cochrane evidence based reviews: intestinal pseudo-obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

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Anatomical Context for Intestinal Pseudo-Obstruction

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MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

33
Heart, T cells, Brain, Lung, Colon, Endothelial, Prostate

Animal Models for Intestinal Pseudo-Obstruction or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.0EDN3, L1CAM, POLG, SOX10
2MP:00053907.9ATXN7, FLNA, L1CAM, POLG, SST, TYMP
3MP:00053817.6EDN3, FLNA, POLG, RET, SOX10, SST
4MP:00053867.4ATXN7, EDN3, FLNA, L1CAM, RET, SOX10
5MP:00053786.8ATXN7, FLNA, L1CAM, POLG, RET, SOX10
6MP:00107686.5ATXN7, EDN3, FLNA, L1CAM, POLG, RET
7MP:00036316.4ATXN7, EDN3, FLNA, L1CAM, POLG, RET

Publications for Intestinal Pseudo-Obstruction

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Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 440)
idTitleAuthorsYear
1
Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls. (26661570)
2016
2
Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review. (26078585)
2015
3
Kawasaki's disease: an often overlooked cause of intestinal pseudo-obstruction in children. (26386569)
2015
4
Advancement in the clinical management of intestinal pseudo-obstruction. (25020006)
2014
5
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. (24177421)
2013
6
Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction. (23018539)
2012
7
Retraction of article. Eugen Florin Georgescu, Ion Vasile, Ana Claudia Georgescu. Intestinal pseudo-obstruction--a rare condition with heterogeneous etiology and unpredictable outcome. A case report. J Gastrointestin Liver Dis. March 2008; 17(1): 77-80. (22720315)
2012
8
Raising awareness about chronic intestinal pseudo-obstruction (CIPO): a case report showing CIPO as initial manifestation of atypical seronegative systemic sclerosis. (23059804)
2012
9
Prognostic yield of esophageal manometry in chronic intestinal pseudo-obstruction: a retrospective cohort of 116 adult patients. (22762287)
2012
10
An interesting case of intestinal pseudo-obstruction: MNGIE. (21922881)
2011
11
Major gastrointestinal manifestations in lupus patients in Asia: lupus enteritis, intestinal pseudo-obstruction, and protein-losing gastroenteropathy. (20947549)
2010
12
Chronic intestinal pseudo-obstruction related to viral infections. (20172270)
2010
13
Frequency of mitochondrial defects in patients with chronic intestinal pseudo-obstruction. (19344718)
2009
14
Intestinal pseudo-obstruction associated with polymyositis successfully treated with somatostatin analog]. (18323156)
2008
15
Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis. (18955007)
2008
16
Fibrosing gastrointestinal leiomyositis as a cause of chronic intestinal pseudo-obstruction in an 8-month-old dog. (17197634)
2007
17
Chronic intestinal pseudo-obstruction due to buserelin-induced formation of anti-GnRH antibodies. (17241858)
2007
18
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
19
Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction. (16329126)
2006
20
Semiquantitative assessment of the intestinal motility in chronic intestinal pseudo-obstruction in systemic sclerosis and mixed connective tissue disease by Sitzmarks capsule. (17039319)
2006
21
Acute on chronic intestinal pseudo-obstruction as a cause of death in a previously healthy twenty-year-old male. (16614983)
2006
22
Caecal impaction and chronic intestinal pseudo-obstruction in a dog. (15703010)
2005
23
Multivisceral transplantation for pediatric intestinal pseudo-obstruction: single center's experience of 16 cases. (15050142)
2004
24
Prokinetics in the treatment of acute intestinal pseudo-obstruction. (15057661)
2004
25
Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice. (14598259)
2003
26
SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism. (12189494)
2002
27
Rare presentation of intestinal amyloidosis with acute intestinal pseudo-obstruction and perforation. (12401832)
2002
28
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy. (10981652)
2000
29
Intestinal pseudo-obstruction due to neurofibromatosis responding to cisapride. (10812823)
2000
30
Chronic intestinal pseudo-obstruction: treatment and long term follow up of 44 patients. (10373127)
1999
31
Eosinophilic enterocolitis and visceral neuropathy with chronic intestinal pseudo-obstruction. (10372941)
1999
32
Myasthenia gravis, thymoma, intestinal pseudo-obstruction, and neuronal nicotinic acetylcholine receptor antibody. (10514242)
1999
33
Autonomic dysfunction in chronic intestinal pseudo-obstruction. (9869551)
1998
34
Desmin-rich smooth muscle bundles in chronic intestinal pseudo-obstruction. (9327377)
1997
35
Clinical characteristics of chronic idiopathic intestinal pseudo-obstruction in adults. (9414977)
1997
36
Manometric evaluation of gastrointestinal motility in children with chronic intestinal pseudo-obstruction syndrome. (8938348)
1996
37
Pancreatic somatostatinoma presenting with chronic intestinal pseudo-obstruction syndrome. (17912215)
1996
38
Small bowel resection for relief of chronic intestinal pseudo-obstruction. (7541935)
1995
39
Acute intestinal pseudo-obstruction due to malignant thymoma. (8266165)
1993
40
Erythromycin in chronic intestinal pseudo-obstruction. (2362109)
1990
41
Chronic intestinal pseudo-obstruction: progress and problems. (2303965)
1990
42
Chronic intestinal pseudo-obstruction: diagnosis and treatment. (2642997)
1989
43
Intestinal pseudo-obstruction due to dialysis amyloidosis. (2612073)
1989
44
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. (6688501)
1983
45
Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. A paraneoplastic neuropathy of the gastrointestinal tract. (6297344)
1983
46
Radiation-induced recurrent intestinal pseudo-obstruction. (6895001)
1981
47
Chronic intestinal pseudo-obstruction. A report of 27 cases and review of the literature. (6894476)
1981
48
Idiopathic intestinal pseudo-obstruction: a familial visceral neuropathy. (7438508)
1980
49
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979
50
Myxedema ileus. A form of intestinal pseudo-obstruction. (1242154)
1975

Variations for Intestinal Pseudo-Obstruction

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Expression for genes affiliated with Intestinal Pseudo-Obstruction

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Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for genes affiliated with Intestinal Pseudo-Obstruction

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GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

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Biological processes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell migrationGO:00303349.5EDN3, SST
2neural crest cell migrationGO:00017558.9EDN3, RET

Sources for Intestinal Pseudo-Obstruction

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet