MCID: INT072
MIFTS: 39

Intestinal Pseudo-Obstruction malady

Categories: Rare diseases, Gastrointestinal diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Intestinal Pseudo-Obstruction

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Aliases & Descriptions for Intestinal Pseudo-Obstruction:

Name: Intestinal Pseudo-Obstruction 10 45 23 47 12 36 65
Hollow Visceral Myopathy 45 65
Paralytic Ileus 23 65
Congenital Idiopathic Intestinal Pseudoobstruction 65
Chronic Idiopathic Intestinal Pseudo-Obstruction 23
Pseudointestinal Obstruction Syndrome 23
Congenital Short Bowel Syndrome 23
 
Pseudo-Obstruction of Intestine 10
Intestinal Pseudoobstruction 45
Intestine Pseudoobstruction 10
Pseudoobstructive Syndrome 23
Enteric Neuropathy 23
Ciip 23
Ipo 23

Classifications:



External Ids:

Disease Ontology10 DOID:3878
MeSH36 D007418
SNOMED-CT59 235825006
NCIt42 C34733
UMLS65 C0021847, C0400874, C2746068

Summaries for Intestinal Pseudo-Obstruction

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NIH Rare Diseases:45 Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. it may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. the condition is sometimes inherited (in an x-linked recessive or autosomal dominant manner) and may be caused by mutations in the flna gene; it may also be acquired after certain illnesses. the goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. last updated: 4/1/2015

MalaCards based summary: Intestinal Pseudo-Obstruction, also known as hollow visceral myopathy, is related to blind loop syndrome and paralytic ileus. An important gene associated with Intestinal Pseudo-Obstruction is TYMP (Thymidine Phosphorylase). Affiliated tissues include breast, endothelial and t cells, and related mouse phenotypes are pigmentation and skeleton.

Genetics Home Reference:23 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia:68 Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Related Diseases for Intestinal Pseudo-Obstruction

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Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Symptoms for Intestinal Pseudo-Obstruction

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Drugs & Therapeutics for Intestinal Pseudo-Obstruction

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Drugs for Intestinal Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ColaNutraceuticalPhase 3, Phase 21768
2Pharmaceutical SolutionsPhase 27004

Interventional clinical trials:

idNameStatusNCT IDPhase
1Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or SurgeryCompletedNCT00140868Phase 3
2Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001)CompletedNCT01553591Phase 3
3Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3002)CompletedNCT01553747Phase 3
4Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP)CompletedNCT00793247Phase 2
5Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With DiarrheaCompletedNCT01130272Phase 2
6Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After PancreaticoduodenectomyActive, not recruitingNCT01607307Phase 2
7Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstructionRecruitingNCT02731183Phase 1
8Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-upCompletedNCT00213460
9Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure PatientsNot yet recruitingNCT02561819
10Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in InfantsTerminatedNCT01062815

Search NIH Clinical Center for Intestinal Pseudo-Obstruction


Cochrane evidence based reviews: intestinal pseudo-obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

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Anatomical Context for Intestinal Pseudo-Obstruction

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MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

33
Breast, Endothelial, T cells, Lung, Brain, Bone, Heart

Animal Models for Intestinal Pseudo-Obstruction or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.0EDN3, L1CAM, POLG, SOX10
2MP:00053907.9ATXN7, FLNA, L1CAM, POLG, SST, TYMP
3MP:00053817.6EDN3, FLNA, POLG, RET, SOX10, SST
4MP:00053867.4ATXN7, EDN3, FLNA, L1CAM, RET, SOX10
5MP:00053786.8ATXN7, FLNA, L1CAM, POLG, RET, SOX10
6MP:00107686.5ATXN7, EDN3, FLNA, L1CAM, POLG, RET
7MP:00036316.4ATXN7, EDN3, FLNA, L1CAM, POLG, RET

Publications for Intestinal Pseudo-Obstruction

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Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 432)
idTitleAuthorsYear
1
Serological and molecular evidence ofA hepadnavirus infection in swine. (25780820)
2015
2
Polymorphism of dopamine transporter gene DAT1 and individual variability of defense cardiac response in humans. (24824713)
2014
3
Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells. (24970800)
2014
4
Immunohistochemical expression of GPR30 in breast carcinoma of Egyptian patients: an association with immunohistochemical subtypes. (24628533)
2014
5
Analysis of progesterone receptor membrane component 1 mutation in Han Chinese women with premature ovarian failure. (25246111)
2014
6
Benign metastasizing leiomyomatosis of the lungs presenting a miliary pattern. (25441829)
2014
7
Prenatal diagnosis and management of a massive fetal ovarian hemorrhagic cyst torsion with secondary fetal anemia. (24027173)
2013
8
Malignant Transformation from Endometriosis to Atypical Endometriosis and Finally to Endometrioid Adenocarcinoma within 10 Years. (24163664)
2013
9
Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis. (23922243)
2013
10
Periosteal Flap fixation of the Globe for Surgical Treatment of Severe Restrictive Strabismus: A Report of Eight Cases with Outcomes. (22204549)
2011
11
Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung. (21272564)
2011
12
Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups. (20403169)
2010
13
Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface. (20858015)
2010
14
Aberrant changes of Wnt2/beta-catenin signaling pathway induced by sodium nitroprusside in human esophageal squamous cell carcinoma cell lines. (19857041)
2010
15
Targeted therapy for biliary-tract cancer. (20129124)
2010
16
Effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys. (20307270)
2010
17
JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. (20018849)
2010
18
Demethylation of the CD133 gene is frequently detected in early gastric carcinoma. (20530428)
2010
19
Cochlear implant patients with superficial siderosis. (19594083)
2009
20
Transport-related structures and processes of the nuclear pore complex studied through molecular dynamics. (19278659)
2009
21
DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers. (19156137)
2009
22
Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis. (19920869)
2009
23
Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast. (18380893)
2008
24
Alpha v beta 3 and alpha v beta 5 integrins and their role in muscle precursor cell adhesion. (18282143)
2008
25
Repairing DNA damage in xeroderma pigmentosum: T4N5 lotion and gene therapy. (18459526)
2008
26
Sex-based and hormonal contraception effects on the metabolism of nicotine among adolescent tobacco-dependent smokers. (17454704)
2007
27
Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. (17548672)
2007
28
Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe. (17548699)
2007
29
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. (17714434)
2007
30
Interconnection between orexigenic neuropeptide Y- and anorexigenic alpha-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus. (16473335)
2006
31
Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease. (15662537)
2005
32
BDNF acutely modulates synaptic transmission and calcium signalling in developing cortical neurons. (16121035)
2005
33
Treacher Collins syndrome with choanal atresia: one way to handle the airway. (15283837)
2004
34
Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet. (15375170)
2004
35
Activation of cytosolic phospholipase A2 in Her14 fibroblasts by hydrogen peroxide: a p42/44(MAPK)-dependent and phosphorylation-independent mechanism. (15164766)
2004
36
Neuroleptic malignant syndrome and atypical antipsychotic drugs. (15119907)
2004
37
Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide. (15116119)
2004
38
Low-cost instrumentation for the diagnosis of Hirschsprung's disease. (12617357)
2003
39
Colocalization of beta 1,4galactosyltransferase with mannose 6-phosphate receptor in monensin-induced TGN-derived structures. (11444150)
2001
40
Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin. (10547191)
1999
41
Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth. (9257741)
1997
42
Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. (9133562)
1997
43
Molecular characterization of the di-leucine-based internalization motif of the T cell receptor. (8626701)
1996
44
Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome). (8600057)
1996
45
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). (7938165)
1994
46
Postpheochromocytoma erythropoietin-dependent erythrocytosis. A postischemic mechanism? (7978058)
1994
47
In vitro establishment and characterization of a human megakaryoblastic cell line. (2310825)
1990
48
In vitro production of an amyloid-like substance from gamma 3 heavy chain disease protein. (4609897)
1974
49
Studies on therapy of reticulosarcoma (-tosis) with actinomycin. (13415074)
1956
50
The effect of local cortisone in the treatment of syphilitic interstitial keratitis; preliminary report. (14885621)
1951

Variations for Intestinal Pseudo-Obstruction

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Expression for genes affiliated with Intestinal Pseudo-Obstruction

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Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for genes affiliated with Intestinal Pseudo-Obstruction

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GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

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Biological processes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell migrationGO:00303349.5EDN3, SST
2neural crest cell migrationGO:00017558.9EDN3, RET

Sources for Intestinal Pseudo-Obstruction

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet