IPO
MCID: INT072
MIFTS: 46

Intestinal Pseudo-Obstruction (IPO) malady

Categories: Rare diseases, Gastrointestinal diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Intestinal Pseudo-Obstruction

Aliases & Descriptions for Intestinal Pseudo-Obstruction:

Name: Intestinal Pseudo-Obstruction 12 50 25 29 52 42 14 69
Hollow Visceral Myopathy 50 69
Paralytic Ileus 25 69
Congenital Idiopathic Intestinal Pseudoobstruction 69
Chronic Idiopathic Intestinal Pseudo-Obstruction 25
Pseudointestinal Obstruction Syndrome 25
Congenital Short Bowel Syndrome 25
Pseudo-Obstruction of Intestine 12
Intestinal Pseudoobstruction 50
Intestine Pseudoobstruction 12
Pseudoobstructive Syndrome 25
Enteric Neuropathy 25
Ciip 25
Ipo 25

Classifications:



External Ids:

Disease Ontology 12 DOID:3878
MeSH 42 D007418
NCIt 47 C34733
SNOMED-CT 64 235825006
UMLS 69 C0021847

Summaries for Intestinal Pseudo-Obstruction

NIH Rare Diseases : 50 intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. it may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. the condition is sometimes inherited (in an x-linked recessive or autosomal dominant manner) and may be caused by mutations in the flna gene; it may also be acquired after certain illnesses. the goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. last updated: 4/1/2015

MalaCards based summary : Intestinal Pseudo-Obstruction, also known as hollow visceral myopathy, is related to paralytic ileus and intestinal pseudoobstruction, neuronal, and has symptoms including vomiting An important gene associated with Intestinal Pseudo-Obstruction is TYMP (Thymidine Phosphorylase), and among its related pathways/superpathways is Smooth Muscle Contraction. The drugs Cola and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, small intestine and colon, and related phenotypes are cellular and digestive/alimentary

Genetics Home Reference : 25 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia : 71 Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Related Diseases for Intestinal Pseudo-Obstruction

Diseases in the Intestinal Obstruction family:

Intestinal Pseudo-Obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 paralytic ileus 12.5
2 intestinal pseudoobstruction, neuronal 11.9
3 chronic intestinal pseudoobstruction 11.8
4 visceral myopathy 11.5
5 chronic atrial and intestinal dysrhythmia 11.4
6 mitochondrial neurogastrointestinal encephalopathy disease 11.3
7 congenital short bowel syndrome 11.1
8 mungan syndrome 11.1
9 colonic pseudo-obstruction 11.1
10 autoimmune gastrointestinal dysmotility 11.1
11 systemic lupus erythematosus 10.4
12 lupus erythematosus 10.4
13 myopathy 10.3
14 ciliary dyskinesia, due to transposition of ciliary microtubules 10.2 ACTG2 SOX10
15 neuropathy 10.2
16 peritonitis 10.2
17 amyloidosis 10.2
18 hemangioma, capillary infantile 10.1 ACTG2 MYH11
19 deafness, mitochondrial, modifier of 10.1 EDNRB SOX10
20 wdha syndrome 10.1 EDNRB SOX10
21 thymoma 10.1
22 neuronitis 10.1
23 cervical adenofibroma 10.1 EDNRB SOX10
24 syphilitic encephalitis 10.1 FLNA MT-TL1
25 kawasaki disease 10.0
26 myasthenia gravis 10.0
27 waardenburg syndrome, type 4a 10.0 EDNRB RET
28 pancreatitis 9.9
29 myotonic dystrophy 9.9
30 polymyositis 9.9
31 encephalopathy 9.9
32 patellofemoral pain syndrome 9.9 FLNA RET
33 hypoparathyroidism-intellectual disability-dysmorphism syndrome 9.9 RET SYP
34 early-onset parkinson disease 9.9 RET SYP
35 herpetic whitlow 9.9 FLNA RET
36 hirschsprung disease 1 9.9 EDNRB RET
37 cowden syndrome 3 9.9 RET SYP
38 pheochromocytoma 9.9
39 crohn's disease 9.9
40 small cell carcinoma 9.9
41 gastroparesis 9.9
42 pneumatosis cystoides intestinalis 9.9
43 diarrhea 9.9
44 patent ductus arteriosus 9.9
45 constipation 9.9
46 autonomic dysfunction 9.9
47 ichthyosis lamellar 2 9.8 FLNA L1CAM SYP
48 ceroid lipofuscinosis, neuronal, 5 9.8 EDNRB RET SOX10
49 skin pilomatrix carcinoma 9.8 EDNRB RET SOX10
50 urinary tract papillary transitional cell benign neoplasm 9.8 RET SYP

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to Intestinal Pseudo-Obstruction

Symptoms & Phenotypes for Intestinal Pseudo-Obstruction

UMLS symptoms related to Intestinal Pseudo-Obstruction:


vomiting

MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 FLNA L1CAM MYH11 RET SOX10 TYMP
2 digestive/alimentary MP:0005381 9.55 EDNRB FLNA MYH11 RET SOX10
3 nervous system MP:0003631 9.5 EDNRB FLNA L1CAM RET SOX10 SYP
4 respiratory system MP:0005388 9.02 EDNRB FLNA MYH11 RET SOX10

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

Drugs for Intestinal Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Nutraceutical Phase 3,Phase 2
2
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
3
alemtuzumab Approved, Investigational Phase 2 216503-57-0
4
Busulfan Approved, Investigational Phase 2 55-98-1 2478
5
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
6
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
7
rituximab Approved Phase 2 174722-31-7 10201696
8
Thiotepa Approved Phase 2 52-24-4 5453
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
10 Pharmaceutical Solutions Phase 2
11 Alkylating Agents Phase 2
12 Antilymphocyte Serum Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Antineoplastic Agents, Alkylating Phase 2
16 Immunosuppressive Agents Phase 2
17 N-monoacetylcystine Phase 2
18 Thioctic Acid Phase 2
19 Tocopherols Phase 2
20 Tocotrienols Phase 2
21 Vitamins Phase 2
22 Alpha-lipoic Acid Nutraceutical Phase 2
23 Tocopherol Nutraceutical Phase 2
24 Tocotrienol Nutraceutical Phase 2

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section Completed NCT01131416 Phase 2, Phase 3
2 Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery Completed NCT00140868 Phase 3
3 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001) Completed NCT01553591 Phase 3
4 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3002) Completed NCT01553747 Phase 3
5 Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer Withdrawn NCT01389986 Phase 2, Phase 3
6 Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After Pancreaticoduodenectomy Unknown status NCT01607307 Phase 2
7 Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP) Completed NCT00793247 Phase 2
8 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With Diarrhea Completed NCT01130272 Phase 2
9 MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis Recruiting NCT02171104 Phase 2
10 Acupuncture to Prevent Postoperative Bowel Paralysis (Paralytic Ileus) Terminated NCT00065234 Phase 2
11 Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstruction Recruiting NCT02731183 Phase 1
12 Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-up Completed NCT00213460
13 Effects of Laser Acupuncture Therapy on Paralytic Ileus Recruiting NCT03041675
14 Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients Recruiting NCT02561819
15 Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in Infants Terminated NCT01062815

Search NIH Clinical Center for Intestinal Pseudo-Obstruction

Cochrane evidence based reviews: intestinal pseudo-obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

Genetic tests related to Intestinal Pseudo-Obstruction:

id Genetic test Affiliating Genes
1 Intestinal Pseudo-Obstruction 29

Anatomical Context for Intestinal Pseudo-Obstruction

MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

39
Smooth Muscle, Small Intestine, Colon, Lung, Liver, Lymph Node

Publications for Intestinal Pseudo-Obstruction

Articles related to Intestinal Pseudo-Obstruction:

(show top 50) (show all 453)
id Title Authors Year
1
Chronic intestinal pseudo-obstruction in children and adults: diagnosis and therapeutic options. ( 27683196 )
2017
2
Chronic intestinal pseudo-obstruction in a child harboring a founder Hirschsprung RET mutation. ( 27273837 )
2016
3
Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. ( 27520652 )
2016
4
Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls. ( 26661570 )
2016
5
Chronic Intestinal Pseudo-Obstruction: Clinical and Manometric Characteristics in the Chilean Population. ( 27669829 )
2016
6
Intestinal Leiomyositis: A Cause of Chronic Intestinal Pseudo-Obstruction in 6 Dogs. ( 26608226 )
2016
7
Intestinal pseudo-obstruction in patients with systemic sclerosis: an analysis of the Nationwide Inpatient Sample. ( 26615031 )
2016
8
Clinical Features, Morbidity, and Risk Factors of Intestinal Pseudo-obstruction in Systemic Lupus Erythematosus: A Retrospective Case-control Study. ( 26773109 )
2016
9
Chronic Intestinal Pseudo-Obstruction. ( 27305875 )
2016
10
Variants of the ACTG2 gene correlate with degree of severity and presence of megacystis in chronic intestinal pseudo-obstruction. ( 26813947 )
2016
11
Surgical abdomen with intestinal pseudo-obstruction as presenting feature of atypical Kawasaki disease. ( 27654849 )
2016
12
Myofibrillar Myopathy Presenting as Neonatal Intestinal Pseudo-Obstruction: An Extremely Rare Entity. ( 26828629 )
2016
13
Intestinal pseudo-obstruction in mitochondrial diseases. ( 27804144 )
2016
14
Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study. ( 27840368 )
2016
15
Smooth-Muscle Myopathy in Systemic Lupus Erythematosus Presenting With Intestinal Pseudo-Obstruction. ( 27694873 )
2016
16
Mitochondrial respiratory chain complex IV deficiency complicated with chronic intestinal pseudo-obstruction in a neonate. ( 27264907 )
2016
17
Ellis-van Creveld syndrome associated with chronic intestinal pseudo-obstruction. ( 26818569 )
2016
18
Clinical importance of cine-MRI assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction: a retrospective study of 33 patients. ( 27549243 )
2016
19
Chronic intestinal pseudo-obstruction: An unusual presentation. ( 27852553 )
2016
20
Acute lupus pneumonitis followed by intestinal pseudo-obstruction in systemic lupus erythematosus: A case report. ( 27347044 )
2016
21
Two Cases of Chronic Intestinal Pseudo-obstruction: A Comparison of Staining Characteristics of Enteric Visceral Myopathy With Hirschsprung Disease. ( 26808129 )
2016
22
Percutaneous endoscopic cecostomy (introducer method) in chronic intestinal pseudo-obstruction - report of two cases and literature review. ( 26493622 )
2015
23
Clinical analysis of 61 systemic lupus erythematosus patients with intestinal pseudo-obstruction and/or ureterohydronephrosis: a retrospective observational study. ( 25634172 )
2015
24
Kawasaki's disease: an often overlooked cause of intestinal pseudo-obstruction in children. ( 26386569 )
2015
25
Mutations in RAD21 Disrupt Regulation of APOB in Patients With Chronic Intestinal Pseudo-Obstruction. ( 25575569 )
2015
26
Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review. ( 26078585 )
2015
27
A review of 42 cases of intestinal pseudo-obstruction in patients with systemic lupus erythematosus based on case reports. ( 26429329 )
2015
28
A case report of chronic intestinal pseudo-obstruction with autoimmune autonomic ganglionopathy suspected from seropositive results for anti-ganglionic acetylcholine receptor antibody. ( 25744921 )
2015
29
Predictors of intestinal pseudo-obstruction in systemic lupus erythematosus complicated by digestive manifestations: data from a Southern China lupus cohort. ( 26405024 )
2015
30
OP-8 SOCIAL CONCERNS IN CHILDREN BEING INVESTIGATED FOR CHRONIC INTESTINAL PSEUDO-OBSTRUCTION. ( 26439549 )
2015
31
Intestinal pseudo-obstruction following oral baclofen: An unusual complication. ( 26312004 )
2015
32
Intestinal Pseudo-Obstruction as an Initial Manifestation of Systemic Lupus Erythematosus. ( 26131004 )
2015
33
Intestinal pseudo-obstruction in patients with systemic lupus erythematosus: a real diagnostic challenge. ( 25170234 )
2014
34
Familial visceral myopathy diagnosed by exome sequencing of a patient with chronic intestinal pseudo-obstruction. ( 24777424 )
2014
35
Intestinal pseudo-obstruction as a presenting symptom of Guillain-BarrAc syndrome. ( 25015168 )
2014
36
Urinary tract involvement in systemic lupus erythematosus: Coexistence with lupus mesenteric vasculitis or intestinal pseudo-obstruction? ( 24953799 )
2014
37
Acute refractory intestinal pseudo-obstruction in MELAS: efficacy of prucalopride. ( 24789860 )
2014
38
Chronic intestinal pseudo-obstruction: systematic histopathological approach can clinch vital clues. ( 24663670 )
2014
39
Intestinal pseudo-obstruction as an unusual gastrointestinal presentation in pediatric human immunodeficiency virus infection. ( 24453397 )
2014
40
Intestinal pseudo-obstruction in systemic lupus erythematosus: a case report and review of the literature. ( 25546663 )
2014
41
Pediatric chronic intestinal pseudo-obstruction is a rare, serious, and intractable disease: a report of a nationwide survey in Japan. ( 25487487 )
2014
42
Advancement in the clinical management of intestinal pseudo-obstruction. ( 25020006 )
2014
43
Mortality, recurrence, and hospital course of patients with systemic sclerosis-related acute intestinal pseudo-obstruction. ( 25128517 )
2014
44
Iodine Deficiency in a Parenteral Nutrition-Dependent Adolescent With Intestinal Pseudo-obstruction. ( 25261415 )
2014
45
The great masquerader of malignancy: chronic intestinal pseudo-obstruction. ( 25635225 )
2014
46
Intestinal pseudo-obstruction due to small bowel I+-actin deficiency in a child with Ehlers-Danlos syndrome. ( 23963838 )
2013
47
Isolated intestinal transplant for chronic intestinal pseudo-obstruction in adults: long-term outcome. ( 24182815 )
2013
48
Clinical recovery of chronic intestinal pseudo-obstruction with cisapride in a complex pediatric patient. ( 22964344 )
2013
49
Intestinal pseudo-obstruction associated with biliary tract dilatation in a patient with systemic lupus erythematosus. ( 23104391 )
2013
50
Transgastric long tube placement following percutaneous endoscopic gastrostomy for severe chronic intestinal pseudo-obstruction related to systemic sclerosis. ( 24252025 )
2013

Variations for Intestinal Pseudo-Obstruction

ClinVar genetic disease variations for Intestinal Pseudo-Obstruction:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CLMP NM_024769.3(CLMP): c.230delA (p.Glu77Glyfs) deletion Pathogenic rs587776964 GRCh37 Chromosome 11, 122955378: 122955378
2 CLMP NM_024769.3(CLMP): c.821G> A (p.Arg274Gln) single nucleotide variant Pathogenic rs587776965 GRCh37 Chromosome 11, 122945410: 122945410
3 CLMP NM_024769.3(CLMP): c.664C> T (p.Arg222Ter) single nucleotide variant Pathogenic rs587776966 GRCh37 Chromosome 11, 122953808: 122953808
4 CLMP NM_024769.3(CLMP): c.371T> A (p.Val124Asp) single nucleotide variant Pathogenic rs587776967 GRCh37 Chromosome 11, 122955237: 122955237
5 CLMP NM_024769.3(CLMP): c.508C> T (p.Arg170Ter) single nucleotide variant Pathogenic rs765907815 GRCh38 Chromosome 11, 123083728: 123083728

Expression for Intestinal Pseudo-Obstruction

Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for Intestinal Pseudo-Obstruction

Pathways related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.18 ACTG2 MYH11

GO Terms for Intestinal Pseudo-Obstruction

Cellular components related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 myosin filament GO:0032982 8.62 ACTG2 MYH11

Biological processes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.37 EDNRB SOX10
2 response to pain GO:0048265 9.32 EDNRB RET
3 melanocyte differentiation GO:0030318 9.26 EDNRB SOX10
4 posterior midgut development GO:0007497 9.16 EDNRB RET
5 neural crest cell migration GO:0001755 9.13 EDNRB RET SOX10
6 enteric nervous system development GO:0048484 8.8 EDNRB RET SOX10

Sources for Intestinal Pseudo-Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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