MCID: INT072
MIFTS: 46

Intestinal Pseudo-Obstruction malady

Categories: Rare diseases, Gastrointestinal diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Intestinal Pseudo-Obstruction

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Aliases & Descriptions for Intestinal Pseudo-Obstruction:

Name: Intestinal Pseudo-Obstruction 11 48 25 27 50 39 13 68
Hollow Visceral Myopathy 48 68
Paralytic Ileus 25 68
Congenital Idiopathic Intestinal Pseudoobstruction 68
Chronic Idiopathic Intestinal Pseudo-Obstruction 25
Pseudointestinal Obstruction Syndrome 25
Congenital Short Bowel Syndrome 25
 
Pseudo-Obstruction of Intestine 11
Intestinal Pseudoobstruction 48
Intestine Pseudoobstruction 11
Pseudoobstructive Syndrome 25
Enteric Neuropathy 25
Ciip 25
Ipo 25

Classifications:



External Ids:

Disease Ontology11 DOID:3878
MeSH39 D007418
SNOMED-CT62 235825006
NCIt45 C34733

Summaries for Intestinal Pseudo-Obstruction

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NIH Rare Diseases:48 Intestinal pseudo-obstruction is a digestive disorder in which the intestinal walls are unable to contract normally (called hypomotility); the condition resembles a true obstruction, but no actual blockage exists. Signs and symptoms may include abdominal pain; vomiting; diarrhea; constipation; malabsorption of nutrients leading to weight loss and/or failure to thrive; and other symptoms. It may be classified as neuropathic (from lack of nerve function) or myopathic (from lack of muscle function), depending on the source of the abnormality. The condition is sometimes inherited (in an X-linked recessive or autosomal dominant manner) and may be caused by mutations in the FLNA gene; it may also be acquired after certain illnesses. The goal of treatment is to provide relief from symptoms and ensure that nutritional support is adequate. Last updated: 4/1/2015

MalaCards based summary: Intestinal Pseudo-Obstruction, also known as hollow visceral myopathy, is related to paralytic ileus and intestinal pseudoobstruction, neuronal, and has symptoms including constipation, constipation and genitourinary symptoms. An important gene associated with Intestinal Pseudo-Obstruction is TYMP (Thymidine Phosphorylase), and among its related pathways is Smooth Muscle Contraction. Affiliated tissues include smooth muscle, small intestine and colon, and related mouse phenotypes are digestive/alimentary and respiratory system.

Genetics Home Reference:25 Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).

Wikipedia:71 Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the... more...

Related Diseases for Intestinal Pseudo-Obstruction

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Diseases in the Intestinal Obstruction family:

intestinal pseudo-obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1paralytic ileus12.5
2intestinal pseudoobstruction, neuronal11.9
3visceral myopathy11.5
4chronic atrial and intestinal dysrhythmia11.4
5mitochondrial neurogastrointestinal encephalopathy disease11.3
6chronic intestinal pseudoobstruction11.3
7congenital short bowel syndrome11.1
8mungan syndrome11.1
9colonic pseudo-obstruction11.1
10systemic lupus erythematosus10.4
11lupus erythematosus10.4
12jejunal atresia10.3ACTG2, MYH11
13myopathy10.3
14sparganosis10.2FLNA, MT-TL1
15hirschsprung nail hypoplasia dysmorphism10.2EDNRB, SOX10
16ulceration of vulva10.2MT-TL1, TYMP
17conjunctival cancer10.2EDNRB, SOX10
18neuropathy10.2
19peritonitis10.2
20amyloidosis10.2
21thymoma10.1
22neuronitis10.1
23pulmonary immaturity10.1SOX10, SYP
24kawasaki disease10.0
25myasthenia gravis10.0
26pancreatitis9.9
27myotonic dystrophy9.9
28polymyositis9.9
29encephalopathy9.9
30pheochromocytoma9.9
31crohn's disease9.9
32small cell carcinoma9.9
33gastroparesis9.9
34pneumatosis cystoides intestinalis9.9
35diarrhea9.9
36patent ductus arteriosus9.9
37constipation9.9
38autonomic dysfunction9.9
39soft palate cancer9.8FLNA, RET
40hypogonadism cardiomyopathy9.8RET, SYP
41central hypoventilation syndrome, congenital9.8EDNRB, RET
42multiple endocrine neoplasia iib9.8EDNRB, RET
43papillary thymic adenocarcinoma9.7RET, SYP
44lung combined type small cell carcinoma9.7RET, SYP
45lung cancer9.7
46ellis-van creveld syndrome9.7
47meconium ileus9.7
48retinoblastoma9.7
49mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes9.7
50neuronal intranuclear inclusion disease9.7

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:



Diseases related to intestinal pseudo-obstruction

Symptoms & Phenotypes for Intestinal Pseudo-Obstruction

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UMLS symptoms related to Intestinal Pseudo-Obstruction:


constipation, genitourinary symptoms, vomiting

MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7EDNRB, FLNA, MYH11, RET, SOX10
2MP:00053887.9EDNRB, FLNA, MYH11, RET, SOX10
3MP:00053847.8EDNRB, FLNA, L1CAM, MYH11, RET, SOX10
4MP:00036317.5EDNRB, FLNA, L1CAM, RET, SOX10, SYP

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

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Drugs for Intestinal Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ColaNutraceuticalPhase 3, Phase 21881
2Pharmaceutical SolutionsPhase 27793

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean SectionCompletedNCT01131416Phase 2, Phase 3
2Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or SurgeryCompletedNCT00140868Phase 3
3Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001)CompletedNCT01553591Phase 3
4Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3002)CompletedNCT01553747Phase 3
5Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian CancerWithdrawnNCT01389986Phase 2, Phase 3
6Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After PancreaticoduodenectomyUnknown statusNCT01607307Phase 2
7Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP)CompletedNCT00793247Phase 2
8Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With DiarrheaCompletedNCT01130272Phase 2
9Acupuncture to Prevent Postoperative Bowel Paralysis (Paralytic Ileus)SuspendedNCT00065234Phase 2
10Efficacy and Safety of Fecal Microbiota Transplantation for Chronic Intestinal Pseudo-obstructionRecruitingNCT02731183Phase 1
11Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-upCompletedNCT00213460
12Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure PatientsRecruitingNCT02561819
13Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in InfantsTerminatedNCT01062815

Search NIH Clinical Center for Intestinal Pseudo-Obstruction


Cochrane evidence based reviews: intestinal pseudo-obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

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Genetic tests related to Intestinal Pseudo-Obstruction:

id Genetic test Affiliating Genes
1 Intestinal Pseudo-Obstruction27

Anatomical Context for Intestinal Pseudo-Obstruction

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MalaCards organs/tissues related to Intestinal Pseudo-Obstruction:

36
Smooth muscle, Small intestine, Colon, Lung, Liver, Lymph node

Publications for Intestinal Pseudo-Obstruction

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Articles related to Intestinal Pseudo-Obstruction:

(show top 50)    (show all 453)
idTitleAuthorsYear
1
Chronic intestinal pseudo-obstruction in children and adults: diagnosis and therapeutic options. (27683196)
2017
2
Chronic intestinal pseudo-obstruction: An unusual presentation. (27852553)
2016
3
Smooth-Muscle Myopathy in Systemic Lupus Erythematosus Presenting With Intestinal Pseudo-Obstruction. (27694873)
2016
4
Variants of the ACTG2 gene correlate with degree of severity and presence of megacystis in chronic intestinal pseudo-obstruction. (26813947)
2016
5
Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. (27520652)
2016
6
Chronic Intestinal Pseudo-Obstruction. (27305875)
2016
7
Clinical importance of cine-MRI assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction: a retrospective study of 33 patients. (27549243)
2016
8
Intestinal pseudo-obstruction in mitochondrial diseases. (27804144)
2016
9
Ellis-van Creveld syndrome associated with chronic intestinal pseudo-obstruction. (26818569)
2016
10
Myofibrillar Myopathy Presenting as Neonatal Intestinal Pseudo-Obstruction: An Extremely Rare Entity. (26828629)
2016
11
Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study. (27840368)
2016
12
Acute lupus pneumonitis followed by intestinal pseudo-obstruction in systemic lupus erythematosus: A case report. (27347044)
2016
13
Intestinal pseudo-obstruction in patients with systemic sclerosis: an analysis of the Nationwide Inpatient Sample. (26615031)
2016
14
Chronic Intestinal Pseudo-Obstruction: Clinical and Manometric Characteristics in the Chilean Population. (27669829)
2016
15
Mitochondrial respiratory chain complex IV deficiency complicated with chronic intestinal pseudo-obstruction in a neonate. (27264907)
2016
16
Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls. (26661570)
2016
17
Clinical Features, Morbidity, and Risk Factors of Intestinal Pseudo-obstruction in Systemic Lupus Erythematosus: A Retrospective Case-control Study. (26773109)
2016
18
Intestinal Leiomyositis: A Cause of Chronic Intestinal Pseudo-Obstruction in 6 Dogs. (26608226)
2016
19
Chronic intestinal pseudo-obstruction in a child harboring a founder Hirschsprung RET mutation. (27273837)
2016
20
Surgical abdomen with intestinal pseudo-obstruction as presenting feature of atypical Kawasaki disease. (27654849)
2016
21
Two Cases of Chronic Intestinal Pseudo-obstruction: A Comparison of Staining Characteristics of Enteric Visceral Myopathy With Hirschsprung Disease. (26808129)
2016
22
Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review. (26078585)
2015
23
Kawasaki's disease: an often overlooked cause of intestinal pseudo-obstruction in children. (26386569)
2015
24
Mutations in RAD21 Disrupt Regulation of APOB in Patients With Chronic Intestinal Pseudo-Obstruction. (25575569)
2015
25
A review of 42 cases of intestinal pseudo-obstruction in patients with systemic lupus erythematosus based on case reports. (26429329)
2015
26
Predictors of intestinal pseudo-obstruction in systemic lupus erythematosus complicated by digestive manifestations: data from a Southern China lupus cohort. (26405024)
2015
27
Clinical analysis of 61 systemic lupus erythematosus patients with intestinal pseudo-obstruction and/or ureterohydronephrosis: a retrospective observational study. (25634172)
2015
28
A case report of chronic intestinal pseudo-obstruction with autoimmune autonomic ganglionopathy suspected from seropositive results for anti-ganglionic acetylcholine receptor antibody. (25744921)
2015
29
Percutaneous endoscopic cecostomy (introducer method) in chronic intestinal pseudo-obstruction - report of two cases and literature review. (26493622)
2015
30
Intestinal pseudo-obstruction following oral baclofen: An unusual complication. (26312004)
2015
31
OP-8 SOCIAL CONCERNS IN CHILDREN BEING INVESTIGATED FOR CHRONIC INTESTINAL PSEUDO-OBSTRUCTION. (26439549)
2015
32
Intestinal Pseudo-Obstruction as an Initial Manifestation of Systemic Lupus Erythematosus. (26131004)
2015
33
Advancement in the clinical management of intestinal pseudo-obstruction. (25020006)
2014
34
Pediatric chronic intestinal pseudo-obstruction is a rare, serious, and intractable disease: a report of a nationwide survey in Japan. (25487487)
2014
35
Mortality, recurrence, and hospital course of patients with systemic sclerosis-related acute intestinal pseudo-obstruction. (25128517)
2014
36
Intestinal pseudo-obstruction as a presenting symptom of Guillain-BarrAc syndrome. (25015168)
2014
37
Urinary tract involvement in systemic lupus erythematosus: Coexistence with lupus mesenteric vasculitis or intestinal pseudo-obstruction? (24953799)
2014
38
Intestinal pseudo-obstruction in systemic lupus erythematosus: a case report and review of the literature. (25546663)
2014
39
The great masquerader of malignancy: chronic intestinal pseudo-obstruction. (25635225)
2014
40
Intestinal pseudo-obstruction as an unusual gastrointestinal presentation in pediatric human immunodeficiency virus infection. (24453397)
2014
41
Iodine Deficiency in a Parenteral Nutrition-Dependent Adolescent With Intestinal Pseudo-obstruction. (25261415)
2014
42
Familial visceral myopathy diagnosed by exome sequencing of a patient with chronic intestinal pseudo-obstruction. (24777424)
2014
43
Chronic intestinal pseudo-obstruction: systematic histopathological approach can clinch vital clues. (24663670)
2014
44
Acute refractory intestinal pseudo-obstruction in MELAS: efficacy of prucalopride. (24789860)
2014
45
Intestinal pseudo-obstruction in patients with systemic lupus erythematosus: a real diagnostic challenge. (25170234)
2014
46
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. (24177421)
2013
47
Intestinal pseudo-obstruction due to small bowel I+-actin deficiency in a child with Ehlers-Danlos syndrome. (23963838)
2013
48
Assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction using cine-MRI. (23511458)
2013
49
Repetitive Colonoscopic Decompression as a Bridge Therapy before Surgery in a Pregnant Patient with Chronic Intestinal Pseudo-Obstruction. (24143328)
2013
50
Intestinal pseudo-obstruction as a complication of paragangliomas: case report and literature review. (24394736)
2013

Variations for Intestinal Pseudo-Obstruction

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Expression for genes affiliated with Intestinal Pseudo-Obstruction

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Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Pathways for genes affiliated with Intestinal Pseudo-Obstruction

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Pathways related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8ACTG2, MYH11

GO Terms for genes affiliated with Intestinal Pseudo-Obstruction

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Cellular components related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:00329829.8ACTG2, MYH11

Biological processes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1melanocyte differentiationGO:003031810.2EDNRB, SOX10
2peripheral nervous system developmentGO:00074229.9EDNRB, SOX10
3posterior midgut developmentGO:00074979.5EDNRB, RET
4enteric nervous system developmentGO:00484849.3EDNRB, RET, SOX10
5response to painGO:00482659.1EDNRB, RET
6neural crest cell migrationGO:00017559.1EDNRB, RET, SOX10
7nervous system developmentGO:00073999.0EDNRB, L1CAM, RET

Sources for Intestinal Pseudo-Obstruction

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet