MCID: INT046
MIFTS: 39

Intestinal Tuberculosis malady

Gastrointestinal diseases category

Summaries for Intestinal Tuberculosis

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Disease Ontology:9 A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located in intestine. the infection has symptom abdominal pain, has symptom gastrointestinal bleeding, has symptom nausea and has symptom vomiting.

MalaCards based summary: Intestinal Tuberculosis, also known as tuberculosis of intestines, is related to tuberculosis and crohn's disease, and has symptoms including abdominal pain, gastrointestinal bleeding and nausea. An important gene associated with Intestinal Tuberculosis is ADA (adenosine deaminase), and among its related pathways are Purine metabolism and Purine metabolism. The compounds aspirin and alpha,beta-methyleneadenosine-5-diphosphate have been mentioned in the context of this disorder. Affiliated tissues include intestine, liver and colon, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Intestinal Tuberculosis

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Intestinal Tuberculosis, Aliases & Descriptions:

Name: Intestinal Tuberculosis 9 11
Tuberculosis of Intestines 60
 
Tuberculosis of Intestine 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:13282
ICD9CM27 014.8

Related Diseases for Intestinal Tuberculosis

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Graphical network of the top 20 diseases related to Intestinal Tuberculosis:



Diseases related to intestinal tuberculosis

Symptoms for Intestinal Tuberculosis

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Symptoms:

 9
  • abdominal pain
  • gastrointestinal bleeding
  • nausea
  • vomiting

Drugs & Therapeutics for Intestinal Tuberculosis

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Drug clinical trials:

Search ClinicalTrials for Intestinal Tuberculosis

Search NIH Clinical Center for Intestinal Tuberculosis

Genetic Tests for Intestinal Tuberculosis

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Anatomical Context for Intestinal Tuberculosis

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MalaCards organs/tissues related to Intestinal Tuberculosis:

31
Liver, Colon, Testes, Small intestine, Heart, Kidney, Pancreas, Appendix

FMA organs/tissues related to Intestinal Tuberculosis:

14
Intestine

Animal Models for Intestinal Tuberculosis or affiliated genes

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MGI Mouse Phenotypes related to Intestinal Tuberculosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6ACE, NT5E, ADA
2MP:00053977.8ACE, NT5E, PSMB9, ADA

Publications for Intestinal Tuberculosis

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Articles related to Intestinal Tuberculosis:

(show top 50)    (show all 250)
idTitleAuthorsYear
1
Computed tomographic enterography adds value to colonoscopy in differentiating Crohn's disease from intestinal tuberculosis: a potential diagnostic algorithm. (25675175)
2015
2
Differentiation of Crohn's disease from intestinal tuberculosis by clinical and CT enterographic models. (24694791)
2014
3
The utility of platelet, mean platelet volume, and red cell distribution width in the diagnosis of active Crohn's disease and intestinal tuberculosis. (24252895)
2013
4
Effectiveness of interferon-gamma release assays for differentiating intestinal tuberculosis from Crohn's disease: A meta-analysis. (24307809)
2013
5
Intestinal Tuberculosis Sometimes Mimics Crohn`s Disease. (24390954)
2013
6
Intestinal tuberculosis. (24269176)
2013
7
Severe pulmonary tuberculosis complicating intestinal tuberculosis with the entire colorectal ulcers. (24043012)
2013
8
Diagnostic sensitivity of culture and drug resistance patterns in Korean patients with intestinal tuberculosis. (22508109)
2012
9
Intestinal tuberculosis complicated with perforation during anti-tuberculous treatment in a 13-year-old girl with defective mitogen-induced IL-12 production. (22841619)
2012
10
Case of intestinal tuberculosis mimicking Crohn's disease. (23569489)
2012
11
Prospective randomized trial of six-month versus nine-month therapy for intestinal tuberculosis. (19667282)
2009
12
Diagnostic challenges of intestinal tuberculosis in a patient with chronic diarrhoea: case report. (18557255)
2008
13
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
14
Intestinal tuberculosis mimicking Crohn's disease. (17976805)
2007
15
Anti-Saccharomyces cerevisiae antibody does not differentiate between Crohn's disease and intestinal tuberculosis. (17160471)
2007
16
Intestinal tuberculosis and secondary liver abscess. (17117317)
2006
17
PCR amplification of the IS6110 insertion element of Mycobacterium tuberculosis in fecal samples from patients with intestinal tuberculosis. (16672431)
2006
18
Selective jejunal artery pseudoaneurysm embolization in a patient with massive gastrointestinal bleeding due to intestinal tuberculosis. (17046480)
2006
19
Tuberculous peritonitis developing during chemotherapy for pulmonary and intestinal tuberculosis: a case report. (15823196)
2005
20
Imaging findings of intestinal tuberculosis. (15665681)
2005
21
Tissue polymerase chain reaction in diagnosis of intestinal tuberculosis and Crohn's disease. (15906835)
2004
22
Mesenteric artery aneurysms in intestinal tuberculosis as a cause of lower gastrointestinal bleeding. (11178687)
2001
23
A rare case of intestinal tuberculosis in a child. (10484899)
1999
24
Colonofiberscopic diagnosis of intestinal tuberculosis. (9481060)
1998
25
Radiological evaluation of complications of intestinal tuberculosis. (9587753)
1998
26
Retained surgical sponge simulating intestinal tuberculosis. (9114579)
1997
27
Mesenteric vasculopathy in intestinal tuberculosis. (9357183)
1997
28
Inguinal hernia incarceration as a form of intestinal tuberculosis. (8984586)
1996
29
Hyperaggregation of platelets in intestinal tuberculosis: role of platelets in chronic inflammation. (7832193)
1995
30
Value of polymerase chain reaction assay in diagnosis of intestinal tuberculosis and differentiation from Crohn's disease. (7796630)
1995
31
Gallstone disease and lithogenicity of bile in intestinal tuberculosis. (7129559)
1982
32
Primary intestinal tuberculosis following renal transplantation. (7050752)
1982
33
Ileal chloride secretion as a cause of secretory diarrhea in a patient with primary intestinal tuberculosis. (422011)
1979
34
Intestinal tuberculosis: experience at a Canadian teaching institution. (930948)
1977
35
Intestinal tuberculosis. (1052456)
1976
36
Intestinal tuberculosis. (814320)
1975
37
Intestinal tuberculosis with fistula in ano. (5964303)
1966
38
The clinical picture and rare variants of primary gastro-intestinal tuberculosis. (13946985)
1963
39
Changes in the pulse rate of intestinal tuberculosis patients by abdominal pressure. (13164003)
1954
40
Primary intestinal tuberculosis. (14931789)
1952
41
A study of the pulmonary tuberculous patients complicated with intestinal tuberculosis, particularly on the blood and the indican-quantity in the urine; III. A comparison of the indican-quantities on the urine between two groups, the pulmonary tuberculous patients complicated with and without intestinal tuberculosis. (14958414)
1952
42
A study on diagnosis and symptoms of secondary intestinal tuberculosis, compared with roentgenographic findings. (13064633)
1952
43
The late results of paraaminosalicylic acid therapy in secondary intestinal tuberculosis. (13007528)
1952
44
Chemotherapy as prophylaxis against secondary intestinal tuberculosis; a report of 150 autopsies. (14885673)
1951
45
Para-aminosalicylic acid therapy in intestinal tuberculosis. (15410994)
1950
46
Surgical complications of intestinal tuberculosis as seen at necropsy. (18908959)
1948
47
Cicatrizing intestinal tuberculosis and regional enteritis. (18906536)
1947
48
Intestinal tuberculosis; some observations. (20247443)
1947
49
Intestinal Tuberculosis. (20322135)
1941
50
THE CURABILITY OF INTESTINAL TUBERCULOSIS. (20316434)
1927

Variations for Intestinal Tuberculosis

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Expression for genes affiliated with Intestinal Tuberculosis

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Search GEO for disease gene expression data for Intestinal Tuberculosis.

Pathways for genes affiliated with Intestinal Tuberculosis

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Pathways related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
UTP and CTP dephosphorylation II36
ATP ITP metabolism58
purine deoxyribonucleosides salvage36
9.2NT5E, ADA
2
Show member pathways
purine deoxyribonucleosides degradation36
purine nucleotides degradation36
adenine and adenosine salvage II36
adenine and adenosine salvage III36
oxidized GTP and dGTP detoxification36
urate biosynthesis/inosine 5-phosphate degradation36
adenine and adenosine salvage I36
purine ribonucleosides degradation to ribose-1-phosphate36
inosine-5-phosphate biosynthesis36
guanosine nucleotides degradation36
guanine and guanosine salvage36
adenosine nucleotides degradation36
5-aminoimidazole ribonucleotide biosynthesis36
9.2NT5E, ADA
3
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.2NT5E, ADA

Compounds for genes affiliated with Intestinal Tuberculosis

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Sources:
43Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 12DrugBank
See all sources

Compounds related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1aspirin43 49 28 2412.4ACE, ADA
2alpha,beta-methyleneadenosine-5-diphosphate439.4NT5E, ADA
3purine nucleoside439.3NT5E, ADA
4xanthine43 2410.3NT5E, ADA
5pyrimidine43 2410.3NT5E, ADA
6purine43 2410.2ADA, NT5E
7nucleoside439.1NT5E, ADA
8cytarabine43 49 1210.9NT5E, ADA

GO Terms for genes affiliated with Intestinal Tuberculosis

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Cellular components related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1ADA, ACE
2plasma membraneGO:00058868.1ADA, NT5E, ACE, CD53
3extracellular vesicular exosomeGO:00700627.9PSMB9, NT5E, ACE, CD53

Biological processes related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1purine nucleobase metabolic processGO:00061449.2NT5E, ADA
2negative regulation of inflammatory responseGO:00507289.1NT5E, ADA
3nucleobase-containing small molecule metabolic processGO:00550868.9NT5E, ADA
4small molecule metabolic processGO:00442818.7NT5E, PSMB9, ADA

Products for genes affiliated with Intestinal Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Intestinal Tuberculosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet