MCID: INT030
MIFTS: 58

Intracranial Aneurysm

Categories: Rare diseases, Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Intracranial Aneurysm

MalaCards integrated aliases for Intracranial Aneurysm:

Name: Intracranial Aneurysm 12 51 41 14 69
Brain Aneurysm 12 50 51 40 69
Cerebral Arterial Aneurysm 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10941
MeSH 41 D002532
NCIt 46 C34458
SNOMED-CT 64 128609009 42994005

Summaries for Intracranial Aneurysm

NINDS : 50 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  An aneurysm can press on a nerve or surrounding tissue, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are slightly more common in women than in men.  The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. For example, a small, unchanging aneurysm will generally produce no symptoms, whereas a larger aneurysm that is steadily growing may produce symptoms such as headache, numbness, loss of feeling in the face or problems with the eyes. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm and cerebral aneurysms, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Propofol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are cardiovascular system and cellular

MedlinePlus : 40 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. They are sometimes called berry aneurysms because they are often the size of a small berry. Most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. If a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. These can include A droopy eyelid Double vision or other changes in vision Pain above or behind the eye A dilated pupil Numbness or weakness on one side of the face or body Treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. If a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. Any of these symptoms requires immediate medical attention. NIH: National Heart, Lung, and Blood Institute

Wikipedia : 72 Intracranial aneurysm, also known as brain aneurysm, is a cerebrovascular disorder in which weakness in... more...

Related Diseases for Intracranial Aneurysm

Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 aneurysm 31.7 CDKN2B-AS1 ELN LOX
2 cerebral aneurysms 30.3 ELN PKD1
3 arteriovenous malformations of the brain 29.7 CDKN2B-AS1 ENG SOX17
4 connective tissue disease 29.2 COL1A2 COL3A1 ELN FBN2
5 supravalvular aortic stenosis 29.1 ELN LIMK1
6 intracranial aneurysms multiple congenital anomaly 12.0
7 fibromuscular dysplasia 11.5
8 aneurysm, intracranial berry, 4 11.3
9 polycystic kidney disease 1 11.2
10 intracranial berry aneurysm 11.1
11 aneurysm, intracranial berry, 1 11.0
12 aneurysm, intracranial berry, 5 11.0
13 aneurysm, intracranial berry, 3 11.0
14 aneurysm, intracranial berry, 6 11.0
15 aneurysm, intracranial berry, 7 11.0
16 aneurysm, intracranial berry, 8 11.0
17 aneurysm, intracranial berry, 9 11.0
18 aneurysm, intracranial berry, 10 11.0
19 immunodeficiency 31c 11.0
20 aneurysm, intracranial berry, 11 11.0
21 loeys-dietz syndrome 4 11.0
22 familial cerebral saccular aneurysm 10.4 COL3A1 ENG
23 familial abdominal aortic aneurysm 10.4 COL3A1 ELN
24 ehlers-danlos syndrome, vascular type 10.3 COL3A1 ELN
25 cerebritis 10.3
26 larsen-like syndrome 10.3 COL1A2 COL3A1
27 lipoblastoma 10.2 COL1A2 COL3A1
28 kidney disease 10.2
29 polycystic kidney disease 10.2
30 collagen disease 10.2 COL1A2 COL3A1 ELN
31 autosomal dominant polycystic kidney disease 10.2
32 pelvic organ prolapse 10.1 COL3A1 ELN LOX
33 phacogenic glaucoma 10.1 ELN LOX
34 endotheliitis 10.1
35 ehlers-danlos syndrome, classic type, 1 10.1 COL1A2 COL3A1
36 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.1
37 thrombosis 10.1
38 marfan syndrome 10.1 COL1A2 ELN FBN2
39 glaucoma, primary open angle 10.0 CDKN2B CDKN2B-AS1 ELN
40 carotid stenosis 10.0
41 arteriovenous malformation 10.0
42 open-angle glaucoma 9.9 CDKN2B CDKN2B-AS1 ELN
43 moyamoya disease 1 9.9
44 cerebellofaciodental syndrome 9.9
45 tuberous sclerosis 9.9
46 ischemia 9.9
47 aging 9.9
48 anxiety 9.9
49 polyarteritis nodosa, childhood-onset 9.9
50 cervicitis 9.9

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to Intracranial Aneurysm

Symptoms & Phenotypes for Intracranial Aneurysm

UMLS symptoms related to Intracranial Aneurysm:


sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pain, headache, edema, chest pain, back pain, angina pectoris

MGI Mouse Phenotypes related to Intracranial Aneurysm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 PKD1 SOX17 VCAN ACE2 ENG FBN2
2 cellular MP:0005384 10.09 PKD1 SOX17 NOS3 COL3A1 ACE2 CDKN2B
3 homeostasis/metabolism MP:0005376 10.06 PKD1 SOX17 THSD1 VCAN NOS3 ACE2
4 growth/size/body region MP:0005378 10.02 NOS3 PKD1 SOX17 VCAN COL3A1 ACE2
5 mortality/aging MP:0010768 9.9 PKD1 SOX17 VCAN NOS3 ACE2 ENG
6 adipose tissue MP:0005375 9.88 NOS3 PKD1 THSD1 COL3A1 COL1A2
7 digestive/alimentary MP:0005381 9.88 PKD1 SOX17 NOS3 COL3A1 ACE2 ENG
8 integument MP:0010771 9.8 PKD1 COL3A1 ACE2 ENG CDKN2B COL1A2
9 muscle MP:0005369 9.61 PKD1 SOX17 ACE2 ENG FBN2 COL1A2
10 respiratory system MP:0005388 9.17 PKD1 NOS3 ACE2 ENG FBN2 LOX

Drugs & Therapeutics for Intracranial Aneurysm

Drugs for Intracranial Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 158)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
2
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
3
Benzocaine Approved, Investigational Phase 4,Early Phase 1 1994-09-7, 94-09-7 2337
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
5
Desflurane Approved Phase 4 57041-67-5 42113
6
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-78-2 2244
8 Piracetam Approved, Investigational Phase 4 7491-74-9
9
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
10
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
11 tannic acid Approved, Nutraceutical Phase 4,Early Phase 1
12 Etiracetam Investigational Phase 4 33996-58-6
13 Anesthetics Phase 4,Phase 3
14 Anesthetics, General Phase 4,Phase 3
15 Anesthetics, Inhalation Phase 4,Phase 3
16 Central Nervous System Depressants Phase 4,Phase 3
17 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 1
18 Analgesics Phase 4,Phase 3,Phase 1
19 Neurotransmitter Agents Phase 4,Phase 3
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1
21 Anticonvulsants Phase 4
22 Neuroprotective Agents Phase 4,Phase 2,Phase 3
23 Nootropic Agents Phase 4,Phase 2,Phase 3
24 Protective Agents Phase 4,Phase 2,Phase 3
25 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Anesthetics, Intravenous Phase 4,Phase 3
27 Hypnotics and Sedatives Phase 4,Phase 3
28 Adrenergic Agents Phase 4,Phase 3
29 Adrenergic Agonists Phase 4,Phase 3
30 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
31 Adrenergic alpha-Agonists Phase 4,Phase 3
32 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1
33 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1
35 Antipyretics Phase 4,Phase 3,Phase 1
36 Antirheumatic Agents Phase 4,Phase 3,Phase 1
37 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 1
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
39 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
40 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
41
Simvastatin Approved Phase 3 79902-63-9 54454
42
Esmolol Approved Phase 3 81147-92-4, 103598-03-4 59768
43
Ticagrelor Approved Phase 3 274693-27-5 9871419
44
Cholecalciferol Approved, Nutraceutical Phase 2, Phase 3 67-97-0 10883523 5280795 6221
45
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
46
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
47 Cerebrolysin Phase 2, Phase 3
48 Antimetabolites Phase 3
49 Hypolipidemic Agents Phase 3
50 Lipid Regulating Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 208)

# Name Status NCT ID Phase Drugs
1 HYdrogel Coil Versus Bare Platinum Coil in Recanalization Imaging Data Study Unknown status NCT01516658 Phase 4
2 Treatment of Cranial Internal Carotid Artery Aneurysm With Willis Covered Stent and Coil Embolization Unknown status NCT01029938 Phase 4
3 TRAIL: Treatment of Intracranial Aneurysms With LVIS® System Completed NCT02921711 Phase 4
4 The Registry to Study Safety and Performance of the CORDIS Vascular Reconstruction Device and Delivery System Completed NCT00486226 Phase 4
5 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
6 PRET: Patients Prone to Recurrence After Endovascular Treatment Completed NCT00626912 Phase 4
7 A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
8 MAPS Trial: Matrix And Platinum Science Completed NCT00396981 Phase 4
9 Aneurysm Wall Histology Registry Completed NCT01444664 Phase 4
10 Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery Completed NCT02987218 Phase 4 Propofol;Desflurane
11 TARGET Intracranial Aneurysm Coiling Registry Recruiting NCT01748903 Phase 4
12 Flow Diversion in Intracranial Aneurysm Treatment Recruiting NCT01349582 Phase 4
13 Stenting in the Treatment of Aneurysm Trial Recruiting NCT01340612 Phase 4
14 Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil Recruiting NCT02729740 Phase 4
15 Seizure Prophylaxis in Aneurysm Repair Recruiting NCT01801072 Phase 4 Levetiracetam
16 Study of the Penumbra Coil 400 System to Treat Aneurysm Active, not recruiting NCT01465841 Phase 4
17 Study of Antiplatelet Therapy for Intracranial Aneurysm Stent-assisted Coiling Not yet recruiting NCT02224131 Phase 4 Aspirin and clopidogrel;Aspirin and clopidogrel
18 Seizure Prophylaxis in Aneurysm Repair Terminated NCT01974700 Phase 4 Levetiracetam
19 LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy Terminated NCT01762137 Phase 4
20 HydroCoil Cerebral Aneurysm Treatment Trial Terminated NCT01195129 Phase 4
21 Hydrogel Balloon Assisted Intracranial Aneurysm Coiling Registry Withdrawn NCT02037932 Phase 4
22 Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01787123 Phase 2, Phase 3 Intravenous Cerebrolysin
23 Feasibility Study of the LVIS™ (Low-profile Visualized Intraluminal Support)Device Completed NCT01541254 Phase 2, Phase 3
24 Pivotal Study of the LVIS (Low Profile Visualized Intraluminal Support) Completed NCT01793792 Phase 3
25 Complete Occlusion of Coilable Aneurysms Completed NCT00777907 Phase 3
26 Hypothermia During Intracranial Aneurysm Surgery Trial Completed NCT00029133 Phase 3
27 Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial Completed NCT00731627 Phase 3 placebo;simvastatin
28 Esmolol Infusion in Patients Undergoing Craniotomy Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
29 Acetylsalicylic Acid Plus Intensive Blood Pressure Treatment in Patients With Unruptured Intracranial Aneurysms Recruiting NCT03063541 Phase 3 Acetylsalicylic acid
30 Ticagrelor vs Clopidogrel for Platelet Inhibition in Stenting for Cerebral Aneurysm Recruiting NCT02675205 Phase 3 Clopidogrel;Ticagrelor;aspirin
31 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3 Esmolol;Dexmedetomidine
32 Hypovitaminosis D in Neurocritical Patients Recruiting NCT02881957 Phase 2, Phase 3 Cholecalciferol
33 The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms Active, not recruiting NCT01636453 Phase 3
34 Pivotal Study of the FRED Stent System in the Treatment of Intracranial Aneurysms Active, not recruiting NCT01801007 Phase 3
35 A Study Evaluating the Safety and Effectiveness of the PulseRider® Aneurysm Neck Reconstruction Device Used in Conjunction With Endovascular Coil Embolization in the Treatment of Wide-Neck Bifurcation Intracranial Aneurysm Not yet recruiting NCT03383666 Phase 3
36 Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage. Not yet recruiting NCT03187405 Phase 3 EVD + IVF with Alteplase
37 Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
38 Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Unknown status NCT02011321 Phase 2 clevidipine
39 Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage Completed NCT01893190 Phase 1, Phase 2 Nimodipine;Nimodipine Microparticles
40 Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Recruiting NCT01895881 Phase 2 Estradiol;Placebo
41 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
42 Safety and Performance of the Penumbra Liberty Stent in the Treatment of Wide-Neck, Saccular, Intracranial Aneurysms Active, not recruiting NCT01753388 Phase 2
43 Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial Not yet recruiting NCT02875262 Phase 1, Phase 2 Deferoxamine
44 Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of Ruptured Aneurysms Withdrawn NCT02056574 Phase 2 NA-1;Placebo
45 Sildenafil for Prevention of Cerebral Vasospasm Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
46 Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm Withdrawn NCT00871065 Phase 2 Sildenafil citrate
47 Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage Withdrawn NCT01878136 Phase 1, Phase 2 Tissue Plasminogen Activator
48 Canadian eCLIPs™ Safety and Feasibility Study Protocol Unknown status NCT01957683 Phase 1
49 The ENTERPRISE Study - Study of the Enterprise Self-Expanding Stent System Completed NCT00288405 Phase 1
50 Remote Ischemic Preconditioning in Subarachnoid Hemorrhage Completed NCT01158508 Phase 1

Search NIH Clinical Center for Intracranial Aneurysm

Cochrane evidence based reviews: intracranial aneurysm

Genetic Tests for Intracranial Aneurysm

Anatomical Context for Intracranial Aneurysm

MalaCards organs/tissues related to Intracranial Aneurysm:

38
Brain, Eye, Heart, Lung, Kidney, Pituitary, Endothelial

Publications for Intracranial Aneurysm

Articles related to Intracranial Aneurysm:

(show top 50) (show all 821)
# Title Authors Year
1
Aortic Coarctation Complicated with Intracranial Aneurysm: A Case Report and Literature Review. ( 29325938 )
2018
2
Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm. ( 29304371 )
2018
3
Evaluation of Application Value of Transcranial Doppler (TCD) in the Inspection of Cerebral Vasospasm After the Treatment of Intracranial Aneurysm. ( 29399014 )
2018
4
Exome Sequencing Identifies LOXL2 Mutation as a Cause of Familial Intracranial Aneurysm. ( 29107163 )
2018
5
Is fetal-type posterior cerebral artery a risk factor for intracranial aneurysm as analyzed by multislice CT angiography? ( 29434687 )
2018
6
Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI. ( 29300738 )
2018
7
Clip ligation for ruptured intracranial aneurysm in a child with Loeys-Dietz syndrome: case report. ( 29350591 )
2018
8
Circulating neutrophil transcriptome may reveal intracranial aneurysm signature. ( 29342213 )
2018
9
Bioinformatic analysis of gene expression profiling of intracranial aneurysm. ( 29328431 )
2018
10
Intracranial Aneurysm is Associated with High Intracranial Artery Tortuosity. ( 29425982 )
2018
11
Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis. ( 29301971 )
2018
12
The application of the unruptured intracranial aneurysm treatment score: a retrospective, single-center study. ( 29388120 )
2018
13
Combining monoenergetic extrapolations from dual-energy CT with iterative reconstructions: reduction of coil and clip artifacts from intracranial aneurysm therapy. ( 29356855 )
2018
14
Long-term outcomes of Low-profile Visualized Intraluminal Support device usage in stent-assisted coiling of intracranial aneurysm. ( 29422368 )
2018
15
Novel ELN mutation in a family with supravalvular aortic stenosis and intracranial aneurysm. ( 27866049 )
2017
16
Rapid Development of Intracranial Aneurysm Associated with Tuberculous Meningitis. ( 29391085 )
2017
17
DNA Methylation of the PDGFD Gene Promoter Increases the Risk for Intracranial Aneurysms and Brain Arteriovenous Malformations. ( 28346846 )
2017
18
An Integrative Survival Analysis with Identification of Prognostic Factors in the Patients with Coexisting Glioma and Intracranial Aneurysm. ( 29288842 )
2017
19
Aspirin for the Prevention of Intracranial Aneurysm Rupture. ( 28899056 )
2017
20
Anxiety, depression and quality of life in patients with a treated or untreated unruptured intracranial aneurysm. ( 28778800 )
2017
21
Primary Cilia Deficiency Induces Intracranial Aneurysm. ( 28800037 )
2017
22
Unruptured intracranial aneurysm and first episode psychosis: The mystery was finally solved. ( 28953760 )
2017
23
Diagnostic value of 3D time-of-flight magnetic resonance angiography for detecting intracranial aneurysm: a meta-analysis. ( 28887618 )
2017
24
Pipeline embolization device for the treatment of a traumatic intracranial aneurysm in a child. ( 28064352 )
2017
25
Anesthetic management of a patient with Takotsubo cardiomyopathy presenting for surgical clipping of intracranial aneurysm. ( 29416253 )
2017
26
Prevalence of Intracranial Aneurysm in Women With Fibromuscular Dysplasia: A Report From the US Registry for Fibromuscular Dysplasia. ( 28715558 )
2017
27
Differences in Morphologic and Hemodynamic Characteristics for "PHASES-Based" Intracranial Aneurysm Locations. ( 28912279 )
2017
28
Initial Clinical Experience with AView-A Clinical Computational Platform for Intracranial Aneurysm Morphology, Hemodynamics, and Treatment Management. ( 28919570 )
2017
29
Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. ( 28761511 )
2017
30
MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture. ( 28214880 )
2017
31
Clinical outcomes after craniotomy for unruptured intracranial aneurysm in patients with coronary artery disease. ( 28887082 )
2017
32
A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans. ( 28792146 )
2017
33
Treatment of Moyamoya Disease and Unruptured Intracranial Aneurysm in Floating-Harbor Syndrome. ( 28549641 )
2017
34
Relationship between intracranial aneurysms and the severity of autosomal dominant polycystic kidney disease. ( 28884237 )
2017
35
Hyperhomocysteinemia as a Risk Factor for Saccular Intracranial Aneurysm: A Cohort Study in a Chinese Han Population. ( 28943219 )
2017
36
Magnetic Resonance Imaging Susceptibility-Weighted Imaging Lesion and Contrast Enhancement May Represent Infectious Intracranial Aneurysm in Infective Endocarditis. ( 28848178 )
2017
37
Passive smoking is not associated with risk of intracranial aneurysm rupture in nonsmoking women. ( 28765026 )
2017
38
Acute stent thrombosis after stent-assisted coiling in an intracranial aneurysm patient carrying two reduced-function CYP2C19 alleles: A case report. ( 29382029 )
2017
39
A 55-Year-Old Male Presenting with Altered Mental Status - A Complicated Case of Intracranial Aneurysm. ( 28881419 )
2017
40
Clinical and angiographic outcomes following endovascular treatment of very small (3a88mm or smaller) intracranial aneurysm: A single-center experience. ( 28906352 )
2017
41
Anesthetic management in a patient of autosomal dominant polycystic kidney disease with end stage renal disease undergoing endovascular coiling for multiple intracranial aneurysms. ( 28781456 )
2017
42
Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease. ( 28843770 )
2017
43
Gain-of-function STAT1 mutations are associated with intracranial aneurysms. ( 28161409 )
2017
44
Association of intracranial aneurysm rupture with smoking duration, intensity, and cessation. ( 28855408 )
2017
45
Cervical artery tortuosity is associated with intracranial aneurysm. ( 28073311 )
2017
46
Impact of antithrombotic treatment on clinical outcomes after craniotomy for unruptured intracranial aneurysm. ( 28865323 )
2017
47
Regulation of Kruppel-like factor 2 (KLF2) in the pathogenesis of intracranial aneurysm induced by hemodynamics. ( 29312497 )
2017
48
Cavernous angioma presenting with subarachnoid hemorrhage which was diffusely distributed in the basal cisterns and mimicked intracranial aneurysm rupture. ( 28904829 )
2017
49
Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation. ( 28754830 )
2017
50
Circular RNA hsa_circ_0021001 in peripheral blood: a potential novel biomarker in the screening of intracranial aneurysm. ( 29291016 )
2017

Variations for Intracranial Aneurysm

Copy number variations for Intracranial Aneurysm from CNVD:

7 (show top 50) (show all 60)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39938 10 12200000 22600000 Loss Intracranial aneurysm
2 47489 10 94100000 97000000 Amplification HHEX Intracranial aneurysm
3 57447 11 63400000 77100000 Amplification FADD Intracranial aneurysm
4 58058 11 65900000 70400000 Gain Intracranial aneurysm
5 58059 11 65900000 75200000 Gain Intracranial aneurysm
6 61265 11 97200000 110400000 Amplification BIRC2 Intracranial aneurysm
7 61266 11 97200000 110400000 Amplification BIRC3 Intracranial aneurysm
8 65029 12 14800000 26500000 Amplification SLC21A8 Intracranial aneurysm
9 67921 12 46400000 58100000 Amplification PFKM Intracranial aneurysm
10 67922 12 46400000 58100000 Amplification SENP1 Intracranial aneurysm
11 75163 13 17900000 115169878 Copy number Intracranial aneurysm
12 77541 13 45200000 59600000 Copy number Intracranial aneurysm
13 79537 13 73300000 79000000 Amplification Intracranial aneurysm
14 87453 14 73800000 79300000 Gain Intracranial aneurysm
15 119789 18 17200000 19000000 Amplification Intracranial aneurysm
16 122647 18 59000000 73100000 Loss Intracranial aneurysm
17 133739 19 6900000 14000000 Amplification RAD23A Intracranial aneurysm
18 135805 2 121010413 121052286 Amplification RALB Intracranial aneurysm
19 140407 2 197400000 209000000 Amplification ALS2 Intracranial aneurysm
20 140408 2 197400000 209000000 Amplification BMPR2 Intracranial aneurysm
21 140409 2 197400000 209000000 Amplification CYP20A1 Intracranial aneurysm
22 140410 2 197400000 209000000 Amplification NOP5 Intracranial aneurysm
23 140411 2 197400000 209000000 Amplification SUMO1 Intracranial aneurysm
24 140412 2 197400000 209000000 Amplification WDR12 Intracranial aneurysm
25 150455 20 1 5100000 Gain Intracranial aneurysm
26 152629 20 32100000 34400000 Gain Intracranial aneurysm
27 154535 20 46400000 49800000 Gain Intracranial aneurysm
28 155818 20 58400000 63025520 Gain Intracranial aneurysm
29 164525 22 37600000 51304566 Amplification PLXNB2 Intracranial aneurysm
30 168338 3 129200000 138700000 Amplification RAB6B Intracranial aneurysm
31 171398 3 167401694 167452651 Amplification PDCD10 Intracranial aneurysm
32 171571 3 169755735 169803181 Amplification Intracranial aneurysm
33 172483 3 182700000 187900000 Amplification LAMP3 Intracranial aneurysm
34 172484 3 182700000 187900000 Amplification MCCC1 Intracranial aneurysm
35 173254 3 192300000 198022430 Amplification TFRC Intracranial aneurysm
36 189115 4 70500000 76300000 Loss Intracranial aneurysm
37 191657 5 1 4500000 Gain Intracranial aneurysm
38 191840 5 10250281 10266501 Amplification CCT5 Intracranial aneurysm
39 194596 5 14143828 14509458 Amplification TRIO Intracranial aneurysm
40 199711 5 42500000 46100000 Gain Intracranial aneurysm
41 202898 5 892968 918164 Amplification TRIP13 Intracranial aneurysm
42 226168 7 55086724 55275031 Amplification EGFR Intracranial aneurysm
43 232751 8 119200000 127300000 Gain Intracranial aneurysm
44 234358 8 134048972 134115310 Amplification SLA Intracranial aneurysm
45 234391 8 134203281 134243932 Amplification WISP1 Intracranial aneurysm
46 234397 8 134249413 134309547 Amplification NDRG1 Intracranial aneurysm
47 239116 8 37701397 37707431 Amplification BRF2 Intracranial aneurysm
48 239184 8 37963348 37997228 Amplification ASH2L Intracranial aneurysm
49 239226 8 38132560 38239790 Amplification WHSC1L1 Intracranial aneurysm
50 239696 8 41119475 41166990 Amplification SFRP1 Intracranial aneurysm

Expression for Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for Intracranial Aneurysm

Pathways related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 COL1A2 COL3A1 ELN FBN2 VCAN
2
Show member pathways
12.75 COL1A2 COL3A1 ELN FBN2 VCAN
3
Show member pathways
12.49 ACE2 COL1A2 COL3A1 ELN LOX
4
Show member pathways
11.75 COL1A2 COL3A1 ELN FBN2 LOX VCAN
5 11.7 COL1A2 COL3A1 NOS3
6 11.58 COL1A2 COL3A1 NOS3
7
Show member pathways
11.54 COL1A2 COL3A1 ELN FBN2 LIMK1 VCAN
8
Show member pathways
11.36 ELN FBN2 LOX
9 11.22 COL1A2 COL3A1 VCAN
10 11.04 COL1A2 NOS3
11 11.01 COL1A2 COL3A1
12 10.88 ENG FBN2
13 10.54 COL1A2 COL3A1 ELN FBN2 LIMK1 VCAN

GO Terms for Intracranial Aneurysm

Cellular components related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ACE2 COL1A2 COL3A1 ELN FBN2 LOX
2 extracellular matrix GO:0031012 9.35 COL1A2 COL3A1 ELN FBN2 VCAN
3 collagen trimer GO:0005581 9.33 COL1A2 COL3A1 LOX
4 proteinaceous extracellular matrix GO:0005578 9.1 COL1A2 COL3A1 ELN FBN2 LOX VCAN

Biological processes related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.58 COL1A2 COL3A1 VCAN
2 heart development GO:0007507 9.56 COL3A1 ENG LOX PKD1
3 digestive tract development GO:0048565 9.43 COL3A1 PKD1
4 renal system development GO:0072001 9.37 PKD1 SOX17
5 blood vessel development GO:0001568 9.33 COL1A2 COL3A1 PKD1
6 response to fluid shear stress GO:0034405 9.32 NOS3 PKD1
7 collagen fibril organization GO:0030199 9.13 COL1A2 COL3A1 LOX
8 extracellular matrix organization GO:0030198 9.1 COL1A2 COL3A1 ELN FBN2 LOX VCAN

Molecular functions related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan binding GO:0005539 9.16 ENG VCAN
2 extracellular matrix structural constituent GO:0005201 9.02 COL1A2 COL3A1 ELN FBN2 VCAN
3 platelet-derived growth factor binding GO:0048407 8.96 COL1A2 COL3A1
4 protein binding GO:0005515 10.07 ACE2 CDKN2B COL1A2 COL3A1 ELN ENG

Sources for Intracranial Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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