Intracranial Aneurysm malady

Wikipedia: A cerebral or brain aneurysm is a cerebrovascular disorder in which weakness in the wall of a cerebral...⁴⁴ more...

MalaCards: Intracranial Aneurysm, also known as intracranial aneurysm (disorder), is related to hypertension and abdominal aortic aneurysm. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Glioma Invasiveness. The compounds glucose and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related mouse phenotypes are endocrine/exocrine gland and embryogenesis.

Aliases & Descriptions:

intracranial aneurysm 6 8 32 43 intracranial aneurysm (disorder) 6

intracranial aneurysm, nos 6

Diseases related to intracranial aneurysm by text searches and GeneDecks gene sharing:

(show top 50)    (show all 619)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	30.0	REN, NOS2, NOS3, ACE
2	abdominal aortic aneurysm	28.6	MMP2, MMP3, MMP9, ELANE, ELN, TIMP1
3	aneurysm disease	28.5	SERPINA1, LPA, MTHFR, MMP9, FBN2, NOS3
4	homocysteine	19.8	RFC1, REN, SERPINE1, SERPINA3, VEGFA, LPA
5	aortic aneurysm	19.6	REN, SERPINE1, VEGFA, LPA, VCAN, MTHFR
6	cervicitis	17.3	RFC1, REN, SERPINA1, SERPINE1, SERPINA3, VEGFA
7	cerebritis	16.7	REN, SERPINA1, SERPINE1, SERPINA3, VEGFA, LPA
8	cerebral aneurysms	13.9	PKD1, ELANE, ELN, TIMP2
9	exfoliation syndrome	13.8	LOXL1, EDNRA, ELN
10	methylmalonic aciduria and homocystinuria	13.7	MTR, CBS, TCN2
11	familial thoracic aortic aneurysm and dissection	13.6	COL3A1, TGFBR1, TGFBR2
12	connective tissue disease	13.6	FBN2, LOX, HSPG2, COL1A2, COL3A1, PKD1
13	hematuria	13.6	COL4A1, COL6A1, COL6A2, ACE
14	pneumothorax	13.5	KDR, COL3A1, ACE, ELANE, ELN
15	thoracic aortic aneurysm	13.5	MMP2, ELN, TGFBR2
16	vitamin b12 deficiency	13.5	MTHFR, MTR, TCN2
17	arteriovenous malformation	13.5	KDR, FLT1, ENG
18	mayer-rokitansky-kuster-hauser syndrome	13.4	SERPINA1, MTR, FBN2, ENG, CBS, CYBA
19	pancytopenia	13.4	CBS, F13A1, ACE, TCN2, DHFR
20	orofacial cleft	13.4	MTHFR, MTR, CBS, NOS3, TCN2
21	neural tube defect	13.4	MTHFR, MTR, CBS, TCN2, SLC19A1
22	porencephaly	13.4	MTHFR, F5, COL4A1
23	thiamine-responsive megaloblastic anemia syndrome	13.4	MTHFR, MTR, TCN2
24	anaplastic oligodendroglioma	13.4	KDR, CDKN2B, CDKN2A, ELN
25	galactosemia	13.4	SERPINA1, SERPINA3, LPA, APOA1, LOX, CBS
26	folic acid deficiency anemia	13.3	MTHFR, MTR, CBS, DHFR, SLC19A1
27	familial hypercholesterolemia	13.3	LPA, APOA1, APOE, CBS
28	telangiectasis	13.3	ENG, ELN, TGFBR1
29	placental abruption	13.3	RFC1, MTHFR, ENG, F5, NOS3, SLC19A1
30	odontogenic myxoma	13.3	SERPINA3, VCAN, MMP2, MMP9
31	homocysteinemia	13.3	MTHFR, MTR, F5, CBS, ELN, SLC19A1
32	tardive dyskinesia	13.3	APOE, HSPG2, NQO1, NOS3, ACE
33	homocystinuria	13.3	MTHFR, MTR, LOX, F5, CBS, TCN2
34	hyperlipidemia type 3	13.3	LPA, APOA1, APOE
35	diastolic heart failure	13.3	MMP2, MMP9, LOXL3, NOS3, ACE
36	polycystic kidney disease, autosomal dominant	13.2	REN, ITGA2, NOS3, PKD1, PKD2, EDNRA
37	carotid artery disease	13.2	LPA, APOA1, APOE, ACE
38	patent foramen ovale	13.2	MTHFR, F5, F13A1, EDNRA
39	birth defects	13.2	MTHFR, MTR, TCN2, DHFR
40	klatskin's tumor	13.2	MMP2, MMP9, FBN2
41	sorsby fundus dystrophy	13.2	MMP3, MMP9, ELN, TIMP1, TIMP3
42	coronary thrombosis	13.2	SERPINE1, ITGB3, GP1BA, F5
43	bleeding diathesis due to gnaq deficiency	13.2	SERPINE1, GP1BA, F5, F13A1
44	migraine with aura	13.2	MTHFR, F5, NOS3, EDNRA, ACE
45	urinary bladder cancer	13.2	KDR, CDKN2B, CDKN2A, FGF1, NQO1
46	hemifacial spasm	13.2	VEGFA, MTHFR, NOS3
47	homocysteine plasma level	13.2	RFC1, MTHFR, MTR, F5, TCN2, DHFR
48	cerebral atherosclerosis	13.1	MTHFR, APOA1, APOE, ACE
49	diffuse astrocytoma	13.1	CDKN2B, CDKN2A, CASP3, EDNRA, TIMP3
50	peripheral vascular disease	13.1	SERPINE1, LPA, APOA1, ACE

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to intracranial aneurysm:

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MGI Mouse Phenotypes related to intracranial aneurysm:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	SLC19A1, SOX17, EDNRA, PKD2, CDKN2B, BOLL
2	embryogenesis phenotype	MP:0005380	10.3	ECE2, SLC19A1, CBS
3	respiratory system phenotype	MP:0005388	10.0	ITGB3, APOE, LOXL1, CBS, F13A1, CYBA
4	hematopoietic system phenotype	MP:0005397	9.8	F13A1, TNFRSF13B, NQO1, COL4A1, LTBP4, TGFBR3
5	integument phenotype	MP:0010771	9.7	NQO1, COL1A2, COL3A1, PKD1, SLC19A1, CBS
6	renal/urinary system phenotype	MP:0005367	9.1	PKD1, PKD2, EDNRA, ACE2, SLC19A1, COL4A1
7	other phenotype	MP:0005395	8.8	PKD1, COL4A1, NOS3, NOS2, HSPG2, APOE
8	liver/biliary system phenotype	MP:0005370	8.6	COL3A1, PKD1, PKD2, SOX17, SLC19A1, NOS3
9	limbs/digits/tail phenotype	MP:0005371	8.2	CBS, HSPG2, COL1A2, PKD1, TGFBR3, APOE
10	immune system phenotype	MP:0005387	7.9	NQO1, PKD1, PKD2, LTBP4, EDNRA, ELANE
11	normal phenotype	MP:0002873	7.6	PKD1, PKD2, EDNRA, ELANE, TIMP2, TGFBR1
12	nervous system phenotype	MP:0003631	7.1	PLCL1, RP1, PKD1, EDNRA, ACVR1, TIMP2
13	growth/size phenotype	MP:0005378	6.7	COL1A2, COL3A1, PKD1, PKD2, ACE, ACVR1
14	skeleton phenotype	MP:0005390	6.6	FBN2, CASP3, COL1A2, PKD1, TGFBR1, TGFBR2
15	tumorigenesis	MP:0002006	6.4	LTBP4, ACE, ELANE, TIMP1, TGFB1, TGFBR1
16	behavior/neurological phenotype	MP:0005386	6.1	PLCL1, NOS2, NOS3, COL4A1, COL1A2, LTBP4
17	reproductive system phenotype	MP:0005389	6.1	SPARCL1, NOS2, PKD1, TIMP1, TIMP3, TGFB1
18	digestive/alimentary phenotype	MP:0005381	6.0	PKD1, PKD2, LTBP4, EDNRA, ACVR1, TGFB1
19	muscle phenotype	MP:0005369	5.2	REN, VEGFA, KDR, CHKB, CDKN2A, ITGB3
20	vision/eye phenotype	MP:0005391	4.9	CASP3, SPARCL1, NOS2, NOS3, RP1, COL4A1
21	mortality/aging	MP:0010768	4.8	ACE, LTBP4, PKD2, PKD1, COL3A1, COL1A2
22	cellular phenotype	MP:0005384	4.1	PKD2, PKD1, COL6A1, COL1A2, COL4A1, NOS3
23	cardiovascular system phenotype	MP:0005385	3.3	PKD1, PKD2, LTBP4, EDNRA, ACE, ACE2
24	homeostasis/metabolism phenotype	MP:0005376	3.2	REN, GP1BA, LOX, F5, CBS, F13A1

Articles related to intracranial aneurysm:

(show top 50)    (show all 72)

id	Title	Authors	Year	Affiliating Genes
1	Association of interleukin-6-572G/C gene polymorphism s in the Cantonese population with intracranial aneurysms. (21497830)	Zhang G.... Qi S.	2011	IL6
2	Expression of vascular endothelial growth factor rece ptor-1/-2 and nitric oxide in unruptured intracranial aneurysms. (20635108)	Maderna E.... Marras C.	2010	FLT1, KDR
3	Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms. (20487632)	Marchese E.... Maira G.	2010	MMP3, TIMP3
4	The Intracranial Aneurysm Susceptibility Genes HSPG2 and CSPG2 Are Not Associated With Abdominal Aortic Aneurysm. (20053631)	Baas A.F.... Ruigrok Y.M.	2010	HSPG2, VCAN
5	Confirmation of an association of single-nucleotide p olymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. (20395613)	Hashikata H.... Koizumi A.	2010	CDKN2A, CDKN2B, CDKN2B-AS1
6	Genome-wide association study to identify genetic var iants present in Japanese patients harboring intracranial aneurysms. (20613766)	Akiyama K.... Inoue I.	2010	ARHGEF11, IQSEC1, AGMO
7	Elastase-induced intracranial aneurysms in hypertensi ve mice. (19884566)	Nuki Y.... Hashimoto T.	2009	ELANE
8	Correlation of COL3A1 gene with type III collagen stability in intracranial aneurysm (18642782)	Hua T.... Zhao J.Z.	2008	COL3A1
9	A polymorphic variant of the endoglin gene is associated with increased risk for intracranial aneurysms in a Korean population. (18440621)	Joo S.P.... Oh C.W.	2008	ENG
10	Meta-analysis of whole-genome linkage scans for intracranial aneurysm. (18069126)	Biros E.... Golledge J.	2008	ECE2, FGF12
11	Polymorphism rs42524 of COL1A2 and sporadic intracranial aneurysms in the Chinese population. (19035720)	Zhu Y.... Pang Q.	2008	COL1A2
12	Genes involved in the transforming growth factor beta signalling pathway and the risk of intracranial aneurysms. (18487557)	Ruigrok Y.M.... Wijmenga C.	2008	TGFB1, HPN, LTBP4
13	Susceptibility loci for intracranial aneurysm in European and Japanese populations. (18997786)	Bilguvar K.... GA1nel M.	2008	CDKN2A, CDKN2B, SOX17
14	Chondroitin sulfate proteoglycan 2 (CSPG2) gene polymorphisms rs173686 and rs251124 are not associated with intracranial aneurysms in Chinese Han nationality. (18484070)	Sun H.... Zhao J.	2007	VCAN
15	The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. (16968986)	Krischek B.... Inoue I.	2007	SERPINA3
16	Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (17287949)	Akagawa H.... Inoue I.	2007	LIMK1, LOXL2, ELN
17	Association of kallikrein gene polymorphisms with intracranial aneurysms. (17761919)	Weinsheimer S.... Tromp G.	2007	KLK1
18	A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms. (16611674)	Akagawa H.... Inoue I.	2006	LIMK1, ELN
19	Evidence in favor of the contribution of genes involved in the maintenance of the extracellular matrix of the arterial wall to the development of intracranial aneurysms. (17038484)	Ruigrok Y.M.... Wijmenga C.	2006	COL4A1, FBN2
20	The role of endothelial nitric oxide synthase (eNOS) genetic variants in European patients with intracranial aneurysms. (16467782)	Krex D.... Schackert G.	2006	NOS3
21	The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. (16961137)	Pannu H.... Milewicz D.M.	2006	MMP2, MMP9
22	Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients. (17121133)	Krischek B.... Inoue I.	2006	NOS3
23	A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3. (16740915)	Verlaan D.J.... Rouleau G.A.	2006	ANIB4
24	Genetics of intracranial aneurysms. (15721828)	Ruigrok Y.M.... Wijmenga C.	2005	ELN
25	Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13. (15540160)	Nahed B.V.... Gunel M.	2005	ANIB3
26	Correlation between APOA gene polymorphism and intracranial aneurysm (15782489)	Zhao Y.L.... Chen B.S.	2005	APOA1
27	A DNA sequence polymorphism in the endoglin gene is not associated with intracranial aneurysm or aneurysmal subarachnoid hemorrhage. (15976502)	Peters D.G.... Chang Y.F.	2005	ENG
28	Lack of an association between the angiotensin-converting enzyme insertion/deletion polymorphism and intracranial aneurysms in a Caucasian population in the United States. (16121979)	Pannu H.... Milewicz D.M.	2005	ACE
29	Examination of ELN as a candidate gene in the Utah intracranial aneurysm pedigrees. (15890991)	Berthelemy-Okazaki N.... Cannon-Albright L.A.	2005	ELN
30	Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm. (14605871)	Farnham J.M.... Cannon-Albright L.A.	2004	ANIB1
31	Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences. (15218274)	Krex D.... Schackert G.	2004	ELN
32	Matrix metalloproteinase-9 coding sequence single-nucleotide polymorphisms in caucasians with intracranial aneurysms. (15214991)	Krex D.... Schackert G.	2004	MMP9
33	Genome-wide scan for Japanese familial intracranial aneurysms: linkage to several chromosomal regions. (15569837)	Yamada S.... Koizumi A.	2004	ACE2, MFAP4
34	Collagen type I alpha2 (COL1A2) is the susceptible gene for intracranial aneurysms. (14739420)	Yoneyama T.... Inoue I.	2004	COL1A2
35	Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. (14605322)	Krex D.... Schackert G.	2003	TIMP2, TIMP1, TIMP3
36	Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms. (13130177)	Krex D.... Schackert G.	2003	NQO1, CYBA
37	Absence of linkage of familial intracranial aneurysms to 7q11 in highly aggregated Japanese families. (12649519)	Yamada S.... Koizumi A.	2003	ELN
38	Endoglin is not a major susceptibility gene for intracranial aneurysm among Japanese. (12775886)	Onda H.... Inoue I.	2003	ENG
39	Endothelial nitric oxide synthase T-786C single nucleotide polymorphism: a putative genetic marker differentiating small versus large ruptured intracranial aneurysms. (14576373)	Khurana V.G.... Meissner I.	2003	NOS3
40	Search for intracranial aneurysm susceptibility gene(s) using Finnish families. (12153705)	Olson J.M.... Tromp G.	2002	ANIB2
41	Genetic evaluation of lipoprotein(a) in intracranial aneurysm disease. (11440434)	Roberts G.A.... Collins P.B.	2001	LPA
42	Molecular anatomy of an intracranial aneurysm: coordinated expression of genes involved in wound healing and tissue remodeling. (11283408)	Peters D.G.... Brufsky A.	2001	COL3A1, COL6A1, COL6A2
43	Lack of association between endoglin intron 7 insertion polymorphism and intracranial aneurysms in a white population: evidence of racial/ethnic differences. (11692035)	Krex D.... Schackert G.	2001	ENG
44	The ACE I allele is associated with increased risk for ruptured intracranial aneurysms. (10882751)	Keramatipour M.... Rubinsztein D.C.	2000	ACE
45	Elastin degradation in the superficial temporal arteries of patients with intracranial aneurysms reflects changes in plasma elastase. (10598723)	Stehbens W.E.	1999	ELN
46	Type III collagen deficiency in saccular intracranial aneurysms. Defect in gene regulation? (10436112)	van den Berg J.S.... Limburg M.	1999	COL3A1
47	Elastin degradation in the superficial temporal arteries of patients with intracranial aneurysms reflects changes in plasma elastase. (9766336)	Marshman L.A.	1998	ELN
48	Does a routine operation for intracranial aneurysm incur brain damage? (8561029)	Rabow L.... Zygmunt S.	1995	CHKB
49	Continuous alprenolol infusion for control of hypertension in the acute stage of ruptured intracranial aneurysms. (1720217)	Touho H.... Shibamoto K.	1991	REN
50	Morphometric analysis of reticular and elastin fibers in the cerebral arteries of patients with intracranial aneurysms. (2362672)	Chyatte D.... Tilson M.D.	1990	ELN

Genes related to intracranial aneurysm according to GeneCards:

(show top 50)    (show all 93)

id	Symbol	Description	Score	GeneCards Section Context
1	CDKN2B-AS1	CDKN2B antisense RNA 1	11.1	Publications, Summaries
2	AGMO	alkylglycerol monooxygenase	11.1	Summaries, Publications
3	ELN	elastin	11.0	Publications
4	COL3A1	collagen, type III, alpha 1	11.0	Publications
5	LIMK1	LIM domain kinase 1	11.0	Publications
6	ENG	endoglin	11.0	Publications
7	LOX	lysyl oxidase	11.0	Publications
8	ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	11.0	Publications
9	COL1A2	collagen, type I, alpha 2	11.0	Publications
10	FBN2	fibrillin 2	11.0	Publications
11	PKD2	polycystic kidney disease 2 (autosomal dominant)	11.0
12	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
13	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.0
14	ELANE	elastase, neutrophil expressed	11.0	Publications
15	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
16	ANIB3	aneurysm, intracranial berry 3	11.0	Publications
17	ANIB4	aneurysm, intracranial berry 4	11.0	Publications
18	ANIB2	aneurysm, intracranial berry 2	11.0	Publications
19	ANIB1	aneurysm, intracranial berry 1	11.0	Publications
20	CHCHD2P10	coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 10	11.0	Publications
21	MFAP4	microfibrillar-associated protein 4	11.0	Publications
22	LOXL3	lysyl oxidase-like 3	11.0	Publications
23	SOX17	SRY (sex determining region Y)-box 17	11.0	Publications
24	RP1	retinitis pigmentosa 1 (autosomal dominant)	11.0	Publications
25	GSTO1	glutathione S-transferase omega 1	11.0	Publications
26	LOXL4	lysyl oxidase-like 4	11.0	Publications
27	KLK1	kallikrein 1	11.0	Publications
28	JDP2	Jun dimerization protein 2	11.0	Publications
29	LOXL1	lysyl oxidase-like 1	11.0	Publications
30	HPN	hepsin	11.0	Publications
31	LTBP4	latent transforming growth factor beta binding protein 4	11.0	Publications
32	BOLL	bol, boule-like (Drosophila)	11.0	Publications
33	PIGZ	phosphatidylinositol glycan anchor biosynthesis, class Z	11.0
34	SLC25A16	solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16	11.0
35	SPARCL1	SPARC-like 1 (hevin)	11.0	Publications
36	COL6A1	collagen, type VI, alpha 1	11.0	Publications
37	VCAN	versican	11.0	Publications
38	TCN2	transcobalamin II	11.0	Publications
39	TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	11.0	Publications
40	COL6A2	collagen, type VI, alpha 2	11.0	Publications
41	ECE2	endothelin converting enzyme 2	11.0	Publications
42	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
43	TSPAN5	tetraspanin 5	11.0	Publications
44	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
45	RFC1	replication factor C (activator 1) 1, 145kDa	11.0	Publications
46	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
47	LOXL2	lysyl oxidase-like 2	11.0	Publications
48	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	11.0	Publications
49	CBS	cystathionine-beta-synthase	11.0	Publications
50	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications

Pathways related to intracranial aneurysm according to GeneDecks:

(show top 50)    (show all 106)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.4	LIMK1, TGFBR1, LTBP4, FGF12
2	Glioma Invasiveness36	10.1	FGF1, TIMP3, TIMP1, FGF12, LTBP4
3	ECM-receptor interaction20	10.0	ITGA2, HSPG2, ITGB3, GP1BA, COL4A1, COL1A2
4	Intrinsic Prothrombin Activation Pathway36	10.0	COL6A1, COL6A2, F5, KLK1, COL3A1, COL1A2
5	Blood Coagulation Cascade36	9.9	KLK1, COL6A2, COL6A1, F5, COL3A1, COL1A2
6	Breast Cancer Regulation by Stathmin136	9.9	TGFBR3, TGFBR1, TIMP3, LTBP4, FGF12, FGF1
7	CREB Pathway36	9.6	TIMP3, TGFBR1, TGFBR3, LTBP4, FGF12, FGF1
8	Activation of Matrix Metalloproteinases38	9.5	MMP2, TIMP2, TIMP1, ELANE, MMP9, MMP3
9	FAK1 Signaling36	9.4	ITGB3, FBN2, HSPG2, COL4A1, ELN, COL1A2
10	Inhibition of Matrix Metalloproteinases36	9.4	HSPG2, MMP2, MMP3, MMP9, TIMP1, TIMP2
11	Cell adhesion Plasmin signaling10	9.3	KDR, VEGFA, TGFBR3, TGFBR2, TGFBR1, COL4A1
12	Transendothelial Migration of Leukocytes36	9.2	ELN, COL6A2, HSPG2, CYBA, COL6A1, COL3A1
13	Telomerase Components in Cell Signaling36	9.2	TGFBR3, TIMP3, TIMP2, KDR, FLT1, FGF1
14	ILK Signaling36	9.1	TIMP3, TIMP2, TIMP1, ELN, LTBP4, COL6A2
15	Cell adhesion_ECM remodeling41	9.1	MMP9, COL4A1, COL1A2, COL3A1, KLK1, TIMP1
16	Cell adhesion ECM remodeling10	9.1	TIMP1, SERPINE1, VCAN, TIMP3, TIMP2, MMP3
17	eIF2 Pathway36	9.1	FGF12, TGFBR3, TIMP3, TIMP2, TIMP1, IL6
18	UPA-UPAR Pathway36	9.0	ITGB3, ITGA2, SERPINE1, COL6A1, MMP2, MMP3
19	Akt Signaling36	9.0	IL6, FGF12, FGF1, ITGA2, TNFRSF13B, LTBP4
20	Inhibition of Angiogenesis by TSP136	9.0	TGFBR3, CASP3, COL4A1, COL1A2, COL3A1, COL6A1
21	PTEN Pathway36	8.9	KDR, ITGA2, FLT1, FGF1, FGF12, FBN2
22	Paxillin Interactions36	8.9	FGF12, TIMP3, FGF1, KDR, ITGA2, ITGB3
23	Ras Pathway36	8.9	FGF12, TIMP1, TIMP2, TIMP3, FGF1, ARHGEF11
24	Cell adhesion_Plasmin signaling41	8.7	VEGFA, KDR, TGFB1, COL4A1, TGFBR1, TGFBR2
25	eNOS Signaling36	8.6	TGFB1, TIMP2, NOS3, TIMP1, FGF1, FGF12
26	PPAR Pathway36	8.4	LTBP4, IL6, FGF1, TIMP2, TGFBR1, FLT1
27	ERK5 Signaling36	8.1	KDR, FLT1, FGF1, FGF12, IL6, LTBP4
28	Angiogenesis3	8.0	NOS3, TIMP1, TIMP2, TIMP3, TGFB1, TGFBR1
29	ERK Signaling36	7.9	LTBP4, COL6A2, TIMP2, COL6A1, COL3A1, TGFB1
30	Apoptotic Pathways in Synovial Fibroblasts36	7.7	TIMP3, TGFB1, KDR, TGFBR3, TGFBR1, FGF12
31	Nuclear Receptor Activation by Vitamin-A36	7.7	KDR, FLT1, FGF1, FGF12, IL6, LTBP4
32	p70S6K Signaling36	7.6	TIMP2, TIMP3, TGFB1, TGFBR1, TGFBR3, TIMP1
33	Activation of PKC through GPCR36	7.6	TGFBR1, TGFBR3, TGFB1, TIMP3, TIMP2, IL6
34	TGF-Beta Pathway36	7.5	TIMP3, TGFB1, TGFBR1, TIMP2, TGFBR2, FGF12
35	Rac1 Pathway36	7.4	IL6, LTBP4, KDR, TIMP1, TGFBR3, TGFBR1
36	MAPK Family Pathway36	7.4	KDR, TGFBR1, TGFBR2, TGFBR3, TIMP2, TIMP1
37	Renin-Angiotensin Pathway36	7.3	FLT1, KDR, REN, ACE, TGFB1, FGF1
38	Rho Family GTPases36	7.2	ARHGEF11, FLT1, ITGB3, ITGA2, KDR, LIMK1
39	p53 Mediated Apoptosis36	7.1	FGF1, KDR, TGFBR3, TGFBR1, TGFB1, TIMP3
40	DHA Signaling36	7.1	TGFBR3, TIMP2, TIMP3, TGFBR1, TGFB1, TIMP1
41	Antioxidant Action of Vitamin-C36	7.1	TGFBR1, FGF12, IL6, TIMP1, TIMP2, TIMP3
42	Pathways in cancer20	7.1	TGFBR2, TGFBR1, TGFB1, COL4A1, NOS2, FGF12
43	PAK Pathway36	7.1	KDR, FLT1, FGF1, FGF12, CASP3, IL6
44	MAPK Signaling36	7.0	TGFBR3, TGFBR1, HSPG2, FBN2, IL6, FGF12
45	Phospholipase-C Pathway36	7.0	KDR, ITGA2, ITGB3, FLT1, ARHGEF11, FGF1
46	Mitochondrial Apoptosis36	6.9	FLT1, FGF1, FGF12, IL6, CASP3, LTBP4
47	Cellular Apoptosis Pathway36	6.9	FLT1, FGF1, TIMP3, FGF12, IL6, CASP3
48	p38 Signaling36	6.7	KDR, TIMP3, FLT1, TIMP2, TGFB1, TGFBR1
49	Pancreatic Adenocarcinoma36	6.6	KDR, TGFB1, TGFBR1, TGFBR2, TIMP3, TIMP2
50	Molecular Mechanisms of Cancer36	6.5	ACVR1, LTBP4, COL6A2, COL6A1, COL3A1, COL4A1

Compounds related to intracranial aneurysm according to GeneDecks:

(show top 50)    (show all 261)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.5	VCAN, ITGA2, GP1BA, LOX
2	hyaluronic acid32 18	11.3	TIMP2, VCAN, MMP3, FGF1, ENG, ELANE
3	bleomycin32 9 9	12.2	TGFBR2, NQO1, NOS3, EDNRA, DHFR
4	glycosaminoglycan32	10.2	LOX, FGF1, VCAN, TGFBR3, TIMP3
5	egcg32	10.1	HSPG2, TIMP1, ELANE, TIMP2, EDNRA
6	ascorbic acid32 18	10.8	HSPG2, NQO1, DHFR, TIMP2, CHKB, MMP2
7	pge232	9.8	EDNRA, HSPG2, LOX, APOA1, MMP3, FGF1
8	h2o232	9.6	ELANE, ELN, DHFR, EDNRA, SERPINA1, LPA
9	(4-aminophenyl)mercuric acetate32	9.5	MMP9, ELANE, ELN, TIMP1, MMP2, TIMP2
10	homocysteine32 18	10.0	SLC19A1, SERPINE1, TCN2, TIMP2, CBS, F5
11	vitamin b1232	9.0	TIMP1, CBS, F5, APOE, APOA1, MTR
12	aspartate32	9.0	APOA1, MMP9, MMP2, CDKN2A, CHKB, APOE
13	n acetylcysteine32	9.0	MMP2, MMP9, ELN, NQO1, CYBA, APOE
14	procollagen32	8.7	MMP2, ELN, MMP3, MMP9, LOX, F13A1
15	arginine32	8.6	CBS, NQO1, KLK1, NOS3, SERPINA3, APOE
16	glutamate32	8.4	COL3A1, PKD1, TIMP1, TIMP3, TGFBR2, DHFR
17	ang ii32	8.4	TGFB1, REN, ELN, NOS3, EDNRA, NOS2
18	heparin32 9 18 9	11.3	TIMP1, TIMP2, TIMP3, TGFBR1, ELN, ELANE
19	candesartan32 9 9	10.2	TGFB1, TIMP1, ACE, NOS3, REN, SERPINE1
20	pravastatin32 34 9 18 9	12.0	APOE, APOA1, NOS3, IL6, CHKB, LPA
21	folate32	8.0	SLC19A1, DHFR, SERPINA3, LPA, KDR, MTHFR
22	fibrinogen32	8.0	SERPINA1, SERPINE1, SERPINA3, LPA, CHKB, ITGA2
23	ribonucleic acid32	7.9	TGFBR2, TGFBR1, TGFB1, TIMP3, TIMP1, TIMP2
24	tgf beta132	7.8	SERPINE1, VCAN, KDR, CDKN2B, MMP2, MMP3
25	matrigel32	7.7	SERPINE1, VEGFA, KDR, ITGA2, MMP2, MMP3
26	paraffin32	7.5	TIMP2, TIMP3, TGFB1, TIMP1, ELN, SERPINA1
27	aspirin32 34 18	9.5	SERPINE1, LPA, CHKB, MTHFR, ITGB3, MMP2
28	vitamin d32	7.5	SERPINE1, TIMP1, ELN, ELANE, EDNRA, COL1A2
29	indomethacin32 9 9	9.3	TGFB1, TIMP1, ELN, EDNRA, NOS3, REN
30	calcium32 9 18 9	10.3	FBN2, MFAP4, PLCL1, GP1BA, FLT1, TNFRSF13B
31	atorvastatin32 34 9 18 9	11.2	TIMP1, VEGFA, NOS3, F5, APOE, APOA1
32	cysteine32	7.1	DHFR, FBN2, MMP9, MMP2, CDKN2A, MTR
33	prostacyclin32	7.0	TIMP1, ELANE, REN, SERPINE1, VEGFA, KDR
34	alanine32	6.9	RFC1, CHKB, CDKN2A, ITGB3, MMP2, MMP3
35	ly29400232	6.7	COL1A2, TIMP2, TIMP1, VEGFA, TGFBR1, NOS2
36	methotrexate32 34 42 9 9	10.6	DHFR, SLC19A1, TGFB1, TIMP2, SERPINE1, SERPINA3
37	simvastatin32 34 42 9 18 9	11.6	ACVR1, COL1A2, SERPINE1, VEGFA, LPA, KDR
38	lactate32	6.4	IL6, GP1BA, MMP9, MMP3, MMP2, CHKB
39	vegf32	6.3	REN, NOS3, EDNRA, ELN, TIMP1, TIMP2
40	cholesterol32 9 18 9	9.0	ACE2, CDKN2A, TGFBR2, IL6, FGF1, FLT1
41	nitric oxide32 9 18 9	8.9	SERPINA1, REN, CYBA, NOS2, CBS, SERPINE1
42	actinomycin d32	5.7	SERPINE1, TIMP2, TGFB1, TIMP1, TGFBR2, NOS3
43	tyrosine32	5.6	FLT1, MMP2, VEGFA, ITGB3, SERPINA1, LIMK1
44	dexamethasone32 42 34 9 9	9.4	REN, SERPINE1, SERPINA3, VEGFA, KDR, CHKB
45	creatinine32	5.4	MTHFR, MTR, CDKN2A, MMP2, MMP3, MMP9
46	genistein32 9 18 9	8.4	SERPINE1, VEGFA, KDR, CDKN2A, MMP2, MMP3
47	cycloheximide32	5.0	NOS2, NQO1, CASP3, ELN, TIMP1, TIMP2
48	retinoic acid32 42 18	6.9	CDKN2B, JDP2, MTHFR, KDR, SERPINA3, SERPINE1
49	serine32	4.7	ITGB3, MMP3, MMP9, FLT1, GSTO1, FGF1
50	estrogen32	3.4	TGFBR2, DHFR, TGFBR1, CHKB, KDR, LPA

Cellular components related to intracranial aneurysm according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta receptor homodimeric complex	GO:070022	10.2	TGFBR2, TGFBR1, ENG
2	basement membrane	GO:005604	9.8	LOXL2, HSPG2, TIMP1, TIMP2, TIMP3
3	extracellular matrix	GO:031012	9.5	COL3A1, COL6A1, COL6A2, LTBP4, TIMP3, COL1A2
4	external side of plasma membrane	GO:009897	9.3	TGFBR3, TGFBR2, ACE, TNFRSF13B, ENG, ITGA2
5	cell surface	GO:009986	8.8	TGFBR3, TGFB1, TIMP2, ELANE, ACE2, HPN
6	platelet alpha granule lumen	GO:031093	8.4	TGFB1, TIMP1, F13A1, F5, VEGFA, SERPINE1
7	proteinaceous extracellular matrix	GO:005578	8.4	SPARCL1, COL6A2, LTBP4, ELN, TGFB1, TGFBR3
8	extracellular region	GO:005576	5.2	F5, F13A1, HSPG2, COL4A1, COL1A2, COL3A1
9	extracellular space	GO:005615	4.8	TCN2, LOXL4, LOXL2, LOXL3, F5, HSPG2

Biological processes related to intracranial aneurysm according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen fibril organization	GO:030199	10.6	TGFBR1, COL3A1, COL1A2, LOXL2, LOX
2	protein heterotrimerization	GO:070208	10.5	COL6A2, COL6A1, COL1A2
3	wound healing	GO:042060	10.5	TGFBR1, COL3A1, LOX, ENG, ITGB3
4	blood vessel development	GO:001568	10.3	LOX, COL1A2, TGFBR2, TGFBR3
5	blood vessel remodeling	GO:001974	10.3	ELN, ACE, NOS3, CBS
6	homocysteine metabolic process	GO:050667	10.2	MTHFR, MTR, CBS
7	axon guidance	GO:007411	10.1	COL6A2, COL6A1, COL3A1, COL1A2, COL4A1, ARHGEF11
8	response to cytokine stimulus	GO:034097	10.1	TIMP1, COL3A1, NOS3, SERPINE1, SERPINA1
9	patterning of blood vessels	GO:001569	10.1	TGFBR2, ACVR1, EDNRA, ENG, FLT1
10	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.0	ENG, ACVR1, TGFB1, TGFBR1
11	epithelial to mesenchymal transition	GO:001837	10.0	LOXL2, LOXL3, TGFB1, TGFBR1, TGFBR3
12	response to cholesterol	GO:070723	9.9	TGFBR2, TGFBR1, TGFB1
13	vasculogenesis	GO:001570	9.8	SOX17, TGFBR2, ENG, KDR, VEGFA
14	pathway-restricted SMAD protein phosphorylation	GO:060389	9.8	TGFBR3, TGFBR2, TGFBR1, TGFB1, ACVR1
15	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	9.8	TGFBR3, TGFBR2, TGFBR1, TGFB1, ENG
16	aging	GO:007568	9.8	TGFB1, TIMP3, TIMP1, EDNRA, NOS3, LOXL2
17	regulation of cell proliferation	GO:042127	9.7	TGFBR2, ACE2, PKD2, NOS2, ENG, SERPINE1
18	extracellular matrix disassembly	GO:022617	9.7	TIMP2, TIMP1, ELANE, ENG, MMP9, MMP3
19	negative regulation of epithelial cell proliferation	GO:050680	9.7	CDKN2B, HPN, TGFB1, TGFBR3
20	lipoprotein metabolic process	GO:042157	9.6	HSPG2, APOE, APOA1, LPA
21	nitric oxide biosynthetic process	GO:006809	9.6	NOS3, NOS2, NQO1
22	cell cycle arrest	GO:007050	9.5	TGFBR1, TGFB1, PKD2, PKD1, CDKN2A, CDKN2B
23	extracellular matrix organization	GO:030198	9.5	MMP2, TIMP2, TIMP1, ELN, ELANE, COL6A2
24	positive regulation of protein phosphorylation	GO:001934	9.4	TGFB1, EDNRA, ENG, FGF1, ITGB3, VEGFA
25	heart development	GO:007507	9.4	EDNRA, TGFBR1, TGFBR2, ECE2, PKD2, PKD1
26	transforming growth factor beta receptor signaling pathway	GO:007179	9.3	TGFB1, TGFBR1, TGFBR2, TGFBR3, ACVR1, LTBP4
27	positive regulation of MAP kinase activity	GO:043406	9.0	TGFB1, ELANE, FLT1, VEGFA
28	angiogenesis	GO:001525	9.0	SOX17, COL4A1, NOS3, HSPG2, FGF1, MMP2
29	positive regulation of angiogenesis	GO:045766	8.9	NOS3, FGF1, FLT1, MMP9, KDR, VEGFA
30	proteolysis	GO:006508	8.7	ECE2, ELANE, ACE2, ACE, KLK1, HPN
31	platelet degranulation	GO:002576	8.4	TGFB1, TIMP1, F13A1, F5, APOA1, ITGB3
32	response to hypoxia	GO:001666	8.3	TGFBR3, TGFB1, EDNRA, NOS3, NOS2, LOXL2
33	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	PKD1, PKD2, ACVR1, TGFB1, SOX17, ENG
34	negative regulation of apoptotic process	GO:043066	7.8	TIMP1, ACVR1, EDNRA, HPN, CASP3, IL6
35	positive regulation of cell proliferation	GO:008284	7.6	TGFBR2, TGFBR1, TGFB1, TIMP1, EDNRA, IL6
36	blood coagulation	GO:007596	7.6	F13A1, NOS2, NOS3, COL1A2, TIMP1, TGFB1
37	platelet activation	GO:030168	7.5	F13A1, COL1A2, COL3A1, TIMP1, TGFB1, F5

Molecular functions related to intracranial aneurysm according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein-lysine 6-oxidase activity	GO:004720	10.6	LOX, LOXL4, LOXL2, LOXL3
2	platelet-derived growth factor binding	GO:048407	10.5	COL6A1, COL3A1, COL1A2, COL4A1
3	extracellular matrix structural constituent	GO:005201	10.4	ELN, COL6A2, COL3A1, COL1A2, COL4A1, FBN2
4	glycosaminoglycan binding	GO:005539	10.3	TGFBR3, TGFBR2, LTBP4, ENG, VCAN
5	transforming growth factor beta-activated receptor activity	GO:005024	10.3	TGFBR3, TGFBR2, TGFBR1, LTBP4, ENG
6	activin binding	GO:048185	10.2	ENG, ACVR1, TGFBR3
7	transforming growth factor beta binding	GO:050431	10.2	TGFBR3, TGFBR2, TGFBR1, ACVR1, LTBP4, ENG
8	copper ion binding	GO:005507	10.2	F5, LOXL3, LOXL2, LOXL4, LOXL1, LOX
9	transmembrane receptor protein serine/threonine kinase activity	GO:004675	10.1	ACVR1, TGFBR1, TGFBR2
10	SMAD binding	GO:046332	10.1	TGFBR3, TGFBR2, TGFBR1, ACVR1, COL1A2
11	type II transforming growth factor beta receptor binding	GO:005114	9.9	ENG, TGFB1, TGFBR1, TGFBR3
12	metalloendopeptidase inhibitor activity	GO:008191	9.7	TIMP1, TIMP2, TIMP3
13	cyclin-dependent protein kinase inhibitor activity	GO:004861	9.4	CASP3, CDKN2A, CDKN2B
14	heparin binding	GO:008201	9.0	TGFBR3, ELANE, APOE, FGF12, FGF1, LPA
15	protein binding	GO:005515	3.2	TGFBR3, COL3A1, COL1A2, COL4A1, RP1, NOS3