MCID: INT030
MIFTS: 55

Intracranial Aneurysm malady

Neuronal category

Summaries for Intracranial Aneurysm

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

MalaCards: Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm disease and polycystic kidney disease. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Rho Family GTPases and Cell adhesion ECM remodeling. The compounds desmosine and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are respiratory system and muscle.

NINDS:44 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

Wikipedia:64 An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which... more...

Aliases & Classifications for Intracranial Aneurysm

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

intracranial aneurysm 8 10 45 61
brain aneurysm 8 44 45 34 61
intracranial aneurysm, nos 8


External Ids:

Disease Ontology8 DOID:10941
NCIt40 C34458
SNOMED-CT57 128609009, 42994005
MeSH35 D002532

Related Diseases for Intracranial Aneurysm

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Intracranial Aneurysm family:

intracranial aneurysms multiple congenital anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm disease31.1ELN, ELANE, ENG, SERPINA1, PKD1, PKD2
2polycystic kidney disease30.7PKD1, PKD2
3cerebral aneurysms30.7PKD1, ELANE, ELN
4polycystic kidney disease, autosomal dominant30.6NOS3, PKD1, PKD2
5osteogenesis imperfecta29.9COL1A2, COL3A1
6polycystic liver disease29.9PKD1, PKD2
7intracranial vasospasm10.4
8carotid stenosis10.4
9autosomal dominant disease10.4
10aortic aneurysm10.4
11fibromuscular dysplasia10.4
12tuberous sclerosis10.3
13moyamoya disease10.3
14klippel-trenaunay syndrome10.2
15carotid artery dissection10.2
16abdominal aortic aneurysm10.2
17carotid artery occlusion10.2
18tuberous sclerosis complex10.2
19intracranial aneurysms multiple congenital anomaly10.2
20headache10.2
21blindness10.2
22type i ehlers-danlos syndrome10.1
23pulmonary edema10.1
24arteriovenous malformation10.1
25loeys-dietz syndrome10.1
26intracranial hypotension10.1
27panhypopituitarism10.1
28polyarteritis nodosa10.1
29cortical blindness10.1
30chronic mucocutaneous candidiasis10.1
31n syndrome10.1
32ehlers–danlos syndrome10.1
33aortic coarctation10.1
34progressive hemifacial atrophy10.1
35intracranial arteriovenous malformation10.1
36head injury10.1
37hypoxia10.1
38thromboembolism10.1
39marfan syndrome10.0LOX, COL1A2, COL3A1, FBN2, PKD1, ELN
40connective tissue disease10.0LOX, COL1A2, COL3A1, FBN2, PKD1, ELN
41systemic scleroderma10.0LOX, COL1A2, COL3A1, NOS3, ENG
42hypertension10.0ACE2, NOS3
43atherosclerosis10.0ELN, ELANE, NOS3, LOX
44pneumothorax10.0COL3A1
45pancreatitis10.0ELANE, SERPINA1
46aortic valve stenosis10.0ELN
47mitral valve prolapse10.0FBN2
48primary hyperoxaluria10.0PKD2, PKD1, NOS3, ACE2, SERPINA1, ENG
49pulmonary emphysema10.0ELN, ELANE, SERPINA1
50vascular disease10.0ELN, ELANE

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to intracranial aneurysm

Clinical Features for Intracranial Aneurysm

Drugs & Therapeutics for Intracranial Aneurysm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intracranial Aneurysm

Drug clinical trials:

Search ClinicalTrials for Intracranial Aneurysm

Search NIH Clinical Center for Intracranial Aneurysm

Search CenterWatch for Intracranial Aneurysm

Genetic Tests for Intracranial Aneurysm

Anatomical Context for Intracranial Aneurysm

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Intracranial Aneurysm:

33
Liver, Spinal cord, Brain, Kidney, Lung, Whole blood, Heart, Smooth muscle, Thyroid, Monocytes, T cells, B cells, Endothelial, Temporal lobe, Pituitary

Animal Models for Intracranial Aneurysm or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Intracranial Aneurysm:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.6ELN, LOX, COL3A1, FBN2, PKD2, PKD1
2MP:000536910.5LOX, COL1A2, COL3A1, FBN2, PKD1, NOS3
3MP:000287310.5SOX17, PKD2, PKD1, NOS3, ENG, ELANE
4MP:000538510.4LOX, COL1A2, COL3A1, FBN2, PKD2, PKD1
5MP:001076810.2FBN2, SOX17, COL3A1, COL1A2, LOX, PKD2

Publications for Intracranial Aneurysm

Sources:
51PubMed
See all sources

Articles related to Intracranial Aneurysm:

(show top 50)    (show all 702)
idTitleAuthorsYear
1
The expression of SPARC in human intracranial aneurysms and its relationship with MMP-2/-9. (23516489)
2013
2
Association of single nucleotide polymorphisms of CSPG2 and HSPG2 genes with intracranial aneurysm in ethnic Han Chinese population]. (23568740)
2013
3
Intracranial aneurysm neck size overestimation with 3D rotational angiography: the impact on intra-aneurysmal hemodynamics simulated with computational fluid dynamics. (22899789)
2013
4
Intra-arterial infusion of a glycoprotein IIb/IIIa antagonist for the treatment of thromboembolism during coil embolization of intracranial aneurysm: a comparison of abciximab and tirofiban. (23660289)
2013
5
Awake Motor Examination during Intracranial Aneurysm Surgery. (24056217)
2013
6
Intracranial aneurysm arising from infundibular dilation. (23904431)
2013
7
The angiotensin converting enzyme insertion/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies. (23860151)
2013
8
In vitro and in silico study of intracranial stent treatments for cerebral aneurysms: effects on perforating vessel flows. (22735859)
2013
9
Double-barrel extracranial-intracranial bypass surgery followed by endovascular carotid artery occlusion in a patient with an extracranial giant internal carotid artery aneurysm due to Ehlers-Danlos syndrome. (22993245)
2013
10
Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall. (24252658)
2013
11
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. (22286173)
2012
12
Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure. (22438818)
2012
13
Our capricious vessels: The influence of stent design and vessel geometry on the mechanics of intracranial aneurysm stent deployment. (22483228)
2012
14
Initial experience of intracranial aneurysm embolization using the balloon remodeling technique with Scepter C, a new double-lumen balloon. (22958766)
2012
15
Unruptured intracranial aneurysms in the Familial Intracranial Aneurysm and International Study of Unruptured Intracranial Aneurysms cohorts: differences in multiplicity and location. (22540404)
2012
16
Intracranial aneurysm with concomitant rupture of an undiagnosed visceral artery aneurysm. (21769458)
2012
17
Spontaneous intracranial hemorrhage and multiple intracranial aneurysms in a patient with Roberts/SC phocomelia syndrome. (22044369)
2011
18
Arterial tortuosity syndrome with multiple intracranial aneurysms: a case report. (21403023)
2011
19
The lumbar sedimentation sign: spinal MRI findings in patients with subarachnoid haemorrhage with no demonstrable intracranial aneurysm. (21325365)
2011
20
Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. (20418302)
2010
21
Endovascular treatment of intracranial aneurysms associated with moyamoya disease or moyamoya syndrome. (20977854)
2010
22
Cardiac arrest after intracisternal papaverine instillation during intracranial aneurysm surgery. Case report. (19961315)
2010
23
Reporting standards for endovascular repair of saccular intracranial cerebral aneurysms. (21990640)
2010
24
Thrombosis and subsequent recanalization of a ruptured intracranial aneurysm in 2 children, demonstrating the value of repeating catheter angiography after an initial negative study. (20367338)
2010
25
Infectious intracranial aneurysm: endovascular treatment with onyx case report and review of the literature. (20228483)
2010
26
Hospital mortality and complications of electively clipped or coiled unruptured intracranial aneurysm. (20522817)
2010
27
Tuberous sclerosis with multiple intracranial aneurysms: atypical tuberous sclerosis diagnosed in adult due to third nerve palsy. (20514932)
2010
28
Intracranial aneurysm formation in siblings with pseudoxanthoma elasticum: case report. (21423077)
2010
29
Reporting standards for endovascular repair of saccular intracranial cerebral aneurysms. (19560031)
2009
30
Severe hypotension with intracisternal application of papaverine after clipping of an intracranial aneurysm. (19604547)
2009
31
Anesthetic conduct in cesarean section in a parturient with unruptured intracranial aneurysm. (20011865)
2009
32
Perianeurysmal abscess and meningitis after endovascular coil placement for an intracranial aneurysm. (19485764)
2009
33
Actively bleeding intracranial aneurysm demonstrated by CT angiography. (18980796)
2009
34
Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort. (19506372)
2009
35
Association of kallikrein gene polymorphisms with intracranial aneurysms. (17761919)
2007
36
Intracranial aneurysm and carotid artery stenosis. (16866048)
2006
37
Evidence in favor of the contribution of genes involved in the maintenance of the extracellular matrix of the arterial wall to the development of intracranial aneurysms. (17038484)
2006
38
Role of apoptosis in intracranial aneurysm rupture. (15597763)
2004
39
Pediatric intracranial aneurysm: a diagnostic dilemma solved with contrast-enhanced MR imaging. (12637284)
2003
40
Is there any seasonal influence in spontaneous bleeding of intracranial aneurysm and and/or AVM in Istanbul? (12833198)
2003
41
Preliminary study of tagged MR image velocimetry in a replica of an intracranial aneurysm. (12695188)
2003
42
Association between surgeon seniority and outcome in intracranial aneurysm surgery. (12820753)
2003
43
Intracranial aneurysms in Ehlers-Danlos syndrome type IV in early childhood. (11704406)
2001
44
Genetic evaluation of lipoprotein(a) in intracranial aneurysm disease. (11440434)
2001
45
Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11. (11536080)
2001
46
An unusual association of intracranial aneurysms and oesophageal duplication in a case of Klippel-Trenaunay syndrome. (11198216)
2000
47
Elastin degradation in the superficial temporal arteries of patients with intracranial aneurysms reflects changes in plasma elastase. (9766336)
1998
48
Morphometric analysis of reticular and elastin fibers in the cerebral arteries of patients with intracranial aneurysms. (2362672)
1990
49
Fibromuscular dysplasia accompanied by giant intracranial fusiform aneurysm--report of two cases. (2460787)
1988
50
Intracranial arteriovenous malformation and arterial aneurysm in the same patient. (5935907)
1966

Genetic Variations for Intracranial Aneurysm

Expression for genes affiliated with Intracranial Aneurysm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for genes affiliated with Intracranial Aneurysm

Sources:
52QIAGEN, 12EMD Millipore, 54Reactome, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Intracranial Aneurysm

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1desmosine4510.9ELN, ELANE, SERPINA1, LOX
2ascorbic acid45 2411.9LOX, NOS3, SERPINA1, ENG, ELN
3procollagen4510.9COL1A2
4estrogen4510.9LOX, COL1A2, NOS3, SERPINA1, ENG, ELANE
5trp-p-24510.9PKD2, PKD1
6isodesmosine4510.9ELANE, ELN
7diisopropylfluorophosphate4510.8SERPINA1, ELANE, ELN
8beta-aminopropionitrile4510.8LOX, ELN
9cysteine4510.8LOX, COL1A2, FBN2, SERPINA1, ENG, ELANE
10Collagenase1110.8COL1A2, COL3A1
11alpha-aminoadipic semialdehyde4510.8LOX, ELN
12serine4510.8COL1A2, PKD1, LIMK1, NOS3, SERPINA1, ENG
13nppa4510.8COL1A2, COL3A1
14ethylenediamine4510.8LOX, ELANE
15hydroxylysine4510.8ELN, LOX
16beta-lactam4510.8PKD1, ELANE
17bleomycin45 1111.8LOX, NOS3, ELN
18oxygen45 2411.8LOX, ACE2, SERPINA1, ENG, ELANE
19pentosidine4510.7ELN, LOX
20h2o24510.7LOX, NOS3, SERPINA1, ELANE, ELN
21vitamin d4510.7COL1A2, NOS3, ELANE, ELN
22onoo4510.7SERPINA1, NOS3
23tannins4510.7ELN, ELANE
24(4-aminophenyl)mercuric acetate4510.6ELANE
25sodium dodecylsulfate4510.6ELN, ELANE, NOS3
26nppb45 60 2912.5COL1A2, COL3A1
27d penicillamine4510.5LOX, ELN
28hocl4510.5ELANE, SERPINA1
29sodium nitroprusside4510.4ELN, ELANE, NOS3
30thermolysin4510.2ELN, ELANE

GO Terms for genes affiliated with Intracranial Aneurysm

Sources:
16Gene Ontology
See all sources

Cellular components related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:00213310.5PKD1, PKD2
2motile primary ciliumGO:03151210.5PKD1, PKD2
3extracellular regionGO:00557610.4LOX, COL1A2, COL3A1, FBN2, ACE2, SERPINA1
4extracellular spaceGO:00561510.2LOX, COL1A2, COL3A1, ACE2, SERPINA1, ENG

Biological processes related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.8ELN, LOX, COL1A2, COL3A1, FBN2, ELANE
2extracellular matrix disassemblyGO:02261710.8ELANE, ENG, COL3A1, COL1A2
3collagen fibril organizationGO:03019910.8LOX, COL1A2, COL3A1
4blood vessel developmentGO:00156810.8COL3A1, COL1A2, LOX
5metanephric ascending thin limb developmentGO:07221810.7PKD2, PKD1
6mesonephric tubule developmentGO:07216410.7PKD2, PKD1
7heart loopingGO:00194710.7ENG, PKD2, SOX17
8mesonephric duct developmentGO:07217710.7PKD2, PKD1
9wound healingGO:04206010.7ENG, COL3A1, LOX
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165910.7PKD1, PKD2
11collagen catabolic processGO:03057410.6COL1A2, COL3A1, ELANE
12placenta blood vessel developmentGO:06067410.6PKD1, PKD2
13detection of mechanical stimulusGO:05098210.5PKD2, PKD1
14transforming growth factor beta receptor signaling pathwayGO:00717910.5ENG, COL3A1, COL1A2
15cytoplasmic sequestering of transcription factorGO:04299410.5PKD1, PKD2
16regulation of cell proliferationGO:04212710.4PKD2, ACE2, ENG
17spinal cord developmentGO:02151010.2PKD1, PKD2

Molecular functions related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.5COL3A1, COL1A2
2extracellular matrix structural constituentGO:00520110.2ELN, FBN2, COL3A1, COL1A2

Products for genes affiliated with Intracranial Aneurysm

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Sources for Intracranial Aneurysm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet