MCID: INT030
MIFTS: 56

Intracranial Aneurysm malady

Neuronal diseases category

Summaries for Intracranial Aneurysm

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

MalaCards: Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm disease and polycystic kidney disease. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Rho Family GTPases and Cell adhesion ECM remodeling. The compounds desmosine and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related mouse phenotypes are respiratory system and muscle.

NINDS:43 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

Wikipedia:63 An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which... more...

Aliases & Classifications for Intracranial Aneurysm

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 43NINDS, 33MedlinePlus, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

intracranial aneurysm 8 10 44 60
brain aneurysm 8 43 44 33 60
intracranial aneurysm, nos 8


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Disease Ontology8 DOID:10941
NCIt39 C34458
SNOMED-CT56 128609009, 42994005
MeSH34 D002532

Related Diseases for Intracranial Aneurysm

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17GeneCards, 18GeneDecks
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Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm disease31.0LOX, ELANE, ENG, SERPINA1, PKD1, PKD2
2polycystic kidney disease30.7PKD2, PKD1
3hypertension30.6NOS3, ACE2
4polycystic kidney disease, autosomal dominant30.6PKD2, PKD1, NOS3
5ischemia30.4ENG, NOS3
6alpha 1-antitrypsin deficiency30.3SERPINA1, ELANE
7ehlers-danlos syndrome type iv30.2ELN, COL3A1
8ehlers-danlos syndrome30.2ELN, ELANE
9connective tissue disease29.9FBN2, PKD1, ELN, COL3A1, COL1A2, LOX
10myocardial infarction29.9ACE2, ENG, NOS3, COL3A1
11osteogenesis imperfecta29.9COL1A2, COL3A1
12polycystic liver disease29.9PKD2, PKD1
13intracranial embolism10.8
14cerebritis10.7
15kidney disease10.5
16intracranial vasospasm10.4
17carotid stenosis10.4
18autosomal dominant disease10.4
19intracranial hypertension10.4
20aortic aneurysm10.4
21intracranial thrombosis10.4
22tuberous sclerosis10.3
23moyamoya disease10.3
24klippel-trenaunay syndrome10.2
25carotid artery dissection10.2
26abdominal aortic aneurysm10.2
27carotid artery occlusion10.2
28cervicitis10.2
29arteriovenous fistula10.1
30pulmonary edema10.1
31arteriovenous malformation10.1
32loeys-dietz syndrome10.1
33arachnoiditis10.1
34intracranial hypotension10.1
35panhypopituitarism10.1
36polyarteritis nodosa10.1
37cortical blindness10.1
38chronic mucocutaneous candidiasis10.1
39candidiasis10.1
40cranial nerve palsy10.1
41hemorrhagic disease10.1
42meningitis10.1
43migraine10.1
44multiple sclerosis10.1
45fibromuscular dysplasia10.1
46intracranial aneurysms multiple congenital anomaly10.1
47marfan syndrome10.0FBN2, COL3A1, LOX, PKD1, ELN, COL1A2
48systemic scleroderma10.0NOS3, ENG, LOX, COL3A1, COL1A2
49atherosclerosis10.0ELANE, LOX, ELN, NOS3
50cerebral aneurysms10.0ELANE, PKD1, ELN

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to intracranial aneurysm

Clinical Features for Intracranial Aneurysm

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Drugs & Therapeutics for Intracranial Aneurysm

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intracranial Aneurysm

Drug clinical trials:

Search ClinicalTrials for Intracranial Aneurysm

Search NIH Clinical Center for Intracranial Aneurysm

Search CenterWatch for Intracranial Aneurysm

Genetic Tests for Intracranial Aneurysm

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Anatomical Context for Intracranial Aneurysm

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32MalaCards
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MalaCards organs/tissues related to Intracranial Aneurysm:

32
Brain, Heart, Eye, Lung, Endothelial, Kidney, Pituitary, Bone, Testes, Smooth muscle, Spinal cord, Thyroid, Monocytes, Liver

Animal Models for Intracranial Aneurysm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intracranial Aneurysm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.6ELN, LOX, COL3A1, FBN2, PKD2, PKD1
2MP:000536910.5LOX, COL1A2, COL3A1, FBN2, PKD1, NOS3
3MP:000287310.5SOX17, PKD2, PKD1, NOS3, ENG, ELANE
4MP:000538510.4LOX, COL1A2, COL3A1, FBN2, PKD2, PKD1
5MP:001076810.2FBN2, SOX17, COL3A1, COL1A2, LOX, PKD2

Publications for Intracranial Aneurysm

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50PubMed
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Articles related to Intracranial Aneurysm:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Disappearance of a small intracranial aneurysm as a result of vessel straightening and in-stent stenosis following use of an Enterprise vascular reconstruction device. (23378433)
2014
2
Final results of the multicenter, prospective Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm Study (AMERICA). (24394153)
2014
3
Propose a wall shear stress divergence to estimate the risks of intracranial aneurysm rupture. (24191140)
2013
4
Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment. (23381018)
2013
5
Quantification of intracranial aneurysm morphodynamics from ECG-gated CT angiography. (22884403)
2013
6
Controversy: clipping of asymptomatic intracranial aneurysm that is < 7 mm: no. (23709696)
2013
7
Mind the Gap: Impact of Computational Fluid Dynamics Solution Strategy on Prediction of Intracranial Aneurysm Hemodynamics and Rupture Status Indicators. (24231854)
2013
8
Wall shear stress estimated with phase contrast MRI in an in vitro and in vivo intracranial aneurysm. (23417769)
2013
9
Intraoperative aneurysmal subarachnoid hemorrhage after rupture of a previously undiagnosed intracranial aneurysm during Chiari decompression. (24113160)
2013
10
The risk of headache attributed to surgical treatment of intracranial aneurysms: a cohort study. (23808965)
2013
11
Response to letter regarding article, "Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture". (23800555)
2013
12
Correlation between MMP-2 and NF-I_ B expression of intracranial aneurysm. (23768831)
2013
13
Incidental internal jugular vein thrombosis in a patient with intracranial aneurysm: Implications for the anesthesiologists. (23878466)
2013
14
Single-stage extracranial carotid artery stenting and intracranial aneurysm coiling: technical feasibility and clinical outcome. (23693048)
2013
15
Characteristics of intracranial aneurysms associated with extracranial carotid artery disease in South Korea. (23545151)
2013
16
Benefits of 3D rotational DSA compared with 2D DSA in the evaluation of intracranial aneurysm. (22578227)
2012
17
Spontaneous regression of an unruptured and non-giant intracranial aneurysm. (23115669)
2012
18
Recent advances in cerebrovascular simulation and neuronavigation for the optimization of intracranial aneurysm clipping. (22348657)
2012
19
Infectious intracranial aneurysm presenting with a series of strokes as a complication of pneumococcal meningitis. (23006765)
2012
20
Intracranial aneurysm coiling with PGLA-coated coils versus bare platinum coils: long-term anatomic follow-up. (21503636)
2012
21
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
22
Value of noninvasive imaging in follow-up of intracranial aneurysm. (21125476)
2011
23
Parent vessel size and curvature strongly influence risk of incomplete stent apposition in enterprise intracranial aneurysm stent coiling. (21816918)
2011
24
A wake "anesthesia" for intraoperative language testing during temporary clip application in a patient with giant intracranial aneurysm. (20548174)
2010
25
Genomics of human intracranial aneurysm wall. (19228845)
2009
26
Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection. (18518716)
2008
27
Multiple intracranial aneurysms with intraventricular hemorrhage in a child with unilateral fibromuscular dysplasia of the renal artery. (19066440)
2008
28
Polymorphism rs42524 of COL1A2 and sporadic intracranial aneurysms in the Chinese population. (19035720)
2008
29
MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. (17334927)
2007
30
Postpartum rupture of an intracranial aneurysm. (17267899)
2007
31
The transition from hunterian ligation to intracranial aneurysm clips: a historical perspective. (16819811)
2006
32
Prevention and management of intraprocedural rupture of intracranial aneurysm with detachable coils during embolization. (17004083)
2006
33
Additional Rescue Stent Placement for Stabilization of a Prolapsed Coil during Stent-assisted Coil Embolization of a Wide-Neck Intracranial Aneurysm. (20569580)
2006
34
Intracranial arterial aneurysm vasculopathies: targeting the outer vessel wall. (16136262)
2005
35
Lack of an association between the angiotensin-converting enzyme insertion/deletion polymorphism and intracranial aneurysms in a Caucasian population in the United States. (16121979)
2005
36
Effect of selected factors on the functional capacity of patients in the early period following intracranial aneurysm surgery. (17611463)
2005
37
Spontaneous regression of a primary cerebral tumor following vasospasm caused by subarachnoid hemorrhage due to rupture of an intracranial aneurysm--case report. (15185757)
2004
38
A 4-year-old girl with autosomal dominant polycystic kidney disease complicated by a ruptured intracranial aneurysm. (15322866)
2004
39
Spinal subdural hematoma: a sequela of a ruptured intracranial aneurysm? (12765819)
2003
40
Carotid artery stenting to prevent stroke in a patient with bilateral extracranial internal carotid dissection and vasospasm following rupture of an intracranial aneurysm. (20591257)
2003
41
Guglielmi detachable coil extraction: suction generated by pusher-wire withdrawal after coil detachment within an intracranial aneurysm. (12748107)
2003
42
Endovascular surgery for intracranial aneurysm. Histopathological analysis after embolization using balloon or coil. (20591232)
2003
43
Intracranial aneurysm: seen and unseen. (14570840)
2003
44
Influence of intraventricular hemorrhage on outcome after rupture of intracranial aneurysm. (11778824)
2001
45
Elastin degradation in the superficial temporal arteries of patients with intracranial aneurysms reflects changes in plasma elastase. (10598723)
1999
46
Analysis of phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm. (10406008)
1999
47
Multiple fusiform intracranial aneurysms following curative radiation therapy for suprasellar germinoma. Case report. (6502244)
1984
48
Intracranial arteriovenous malformation with aneurysm of the vein of Galen as cause of heart failure in infancy. Echocardiographic diagnosis and results of treatment. (6824537)
1983
49
Aneurysm of the intracranial carotid artery; syndrome of frontal headache with oculomotor nerve paralysis. (15401446)
1950
50
Intracranial Aneurysm. ? Cerebral Angioma. (19990334)
1935

Genetic Variations for Intracranial Aneurysm

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Expression for genes affiliated with Intracranial Aneurysm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for genes affiliated with Intracranial Aneurysm

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51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Intracranial Aneurysm

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1desmosine4410.9ELN, ELANE, SERPINA1, LOX
2ascorbic acid44 2411.9LOX, NOS3, SERPINA1, ENG, ELN
3procollagen4410.9COL1A2
4estrogen4410.9LOX, COL1A2, NOS3, SERPINA1, ENG, ELANE
5trp-p-24410.9PKD2, PKD1
6isodesmosine4410.9ELANE, ELN
7diisopropylfluorophosphate4410.8SERPINA1, ELANE, ELN
8beta-aminopropionitrile4410.8LOX, ELN
9cysteine4410.8LOX, COL1A2, FBN2, SERPINA1, ENG, ELANE
10Collagenase1110.8COL1A2, COL3A1
11alpha-aminoadipic semialdehyde4410.8LOX, ELN
12serine4410.8COL1A2, PKD1, LIMK1, NOS3, SERPINA1, ENG
13nppa4410.8COL1A2, COL3A1
14ethylenediamine4410.8LOX, ELANE
15hydroxylysine4410.8ELN, LOX
16beta-lactam4410.8PKD1, ELANE
17bleomycin44 1111.8LOX, NOS3, ELN
18oxygen44 2411.8LOX, ACE2, SERPINA1, ENG, ELANE
19pentosidine4410.7ELN, LOX
20h2o24410.7LOX, NOS3, SERPINA1, ELANE, ELN
21vitamin d4410.7COL1A2, NOS3, ELANE, ELN
22onoo4410.7SERPINA1, NOS3
23tannins4410.7ELN, ELANE
24(4-aminophenyl)mercuric acetate4410.6ELANE
25sodium dodecylsulfate4410.6ELN, ELANE, NOS3
26nppb44 59 2812.5COL1A2, COL3A1
27d penicillamine4410.5LOX, ELN
28hocl4410.5ELANE, SERPINA1
29sodium nitroprusside4410.4ELN, ELANE, NOS3
30thermolysin4410.2ELN, ELANE

GO Terms for genes affiliated with Intracranial Aneurysm

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16Gene Ontology
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Cellular components related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:00213310.5PKD1, PKD2
2motile primary ciliumGO:03151210.5PKD1, PKD2
3extracellular regionGO:00557610.4LOX, COL1A2, COL3A1, FBN2, ACE2, SERPINA1
4extracellular spaceGO:00561510.2LOX, COL1A2, COL3A1, ACE2, SERPINA1, ENG

Biological processes related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.8ELN, LOX, COL1A2, COL3A1, FBN2, ELANE
2extracellular matrix disassemblyGO:02261710.8ELANE, ENG, COL3A1, COL1A2
3collagen fibril organizationGO:03019910.8LOX, COL1A2, COL3A1
4blood vessel developmentGO:00156810.8COL3A1, COL1A2, LOX
5metanephric ascending thin limb developmentGO:07221810.7PKD2, PKD1
6mesonephric tubule developmentGO:07216410.7PKD2, PKD1
7heart loopingGO:00194710.7ENG, PKD2, SOX17
8mesonephric duct developmentGO:07217710.7PKD2, PKD1
9wound healingGO:04206010.7ENG, COL3A1, LOX
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165910.7PKD1, PKD2
11collagen catabolic processGO:03057410.6COL1A2, COL3A1, ELANE
12placenta blood vessel developmentGO:06067410.6PKD1, PKD2
13detection of mechanical stimulusGO:05098210.5PKD2, PKD1
14transforming growth factor beta receptor signaling pathwayGO:00717910.5ENG, COL3A1, COL1A2
15cytoplasmic sequestering of transcription factorGO:04299410.5PKD1, PKD2
16regulation of cell proliferationGO:04212710.4PKD2, ACE2, ENG
17spinal cord developmentGO:02151010.2PKD1, PKD2

Molecular functions related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.5COL3A1, COL1A2
2extracellular matrix structural constituentGO:00520110.2ELN, FBN2, COL3A1, COL1A2

Products for genes affiliated with Intracranial Aneurysm

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Sources for Intracranial Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet