MCID: INT030
MIFTS: 48

Intracranial Aneurysm malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Intracranial Aneurysm

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Intracranial Aneurysm, Aliases & Descriptions:

Name: Intracranial Aneurysm 9 11 43 60
 
Brain Aneurysm 9 42 43 32 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:10941
NCIt38 C34458
SNOMED-CT55 42994005, 128609009
MeSH33 D002532

Summaries for Intracranial Aneurysm

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MedlinePlus:32 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

MalaCards based summary: Intracranial Aneurysm, also known as brain aneurysm, is related to polycystic kidney disease and aneurysm. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Calcium channels. The compounds beta-aminopropionitrile and alpha-aminoadipic semialdehyde have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related mouse phenotypes are integument and respiratory system.

NINDS:42 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

Wikipedia:63 An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which... more...

Related Diseases for Intracranial Aneurysm

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Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease31.0PKD2, PKD1
2aneurysm30.8ELANE, LOX, FBN2, ELN, PKD1, PKD2
3ehlers-danlos syndrome, type iv30.7COL3A1, ELN
4ehlers-danlos syndrome30.6ELN, ELANE
5cerebral aneurysms30.6ELANE, PKD1, ELN
6abdominal aortic aneurysm30.5ELANE, ELN
7polycystic liver disease30.3PKD2, PKD1
8osteogenesis imperfecta30.1COL1A2, COL3A1
9polycystic kidney disease, autosomal dominant30.1PKD1, PKD2
10connective tissue disease29.0COL1A2, COL3A1, PKD1, ELN, LOX, FBN2
11cerebritis10.7
12kidney disease10.5
13endotheliitis10.5
14occipital horn syndrome10.5LOX
15fibromuscular dysplasia10.4
16carotid stenosis10.4
17tuberous sclerosis10.4
18ischemia10.4
19emphysema due to aat deficiency10.4ELANE
20supravalvar aortic stenosis10.3ELN, LIMK1
21moyamoya disease10.3
22headache10.3
23menkes disease10.3ELN, LOX
24telangiectasis10.3ENG, ELN
25endometriosis10.3ENG, ELN
26carotid artery occlusion10.2
27cervicitis10.2
28intracranial aneurysms multiple congenital anomaly10.2
29blindness10.2
30keloids10.2ELN, LOX
31polycystic kidney disease 210.2PKD2, PKD1
32pulmonary emphysema10.2ELANE, ELN
33nephronophthisis10.2PKD2, PKD1
34acute respiratory distress syndrome10.2ELN, ELANE
35polycystic kidney and hepatic disease10.2PKD1, PKD2
36williams-beuren syndrome10.2LIMK1, ELN
37migraine10.2
38arteriovenous fistula10.2
39progressive hemifacial atrophy10.2
40carotid artery dissection10.2
41polyarteritis nodosa10.2
42cortical blindness10.2
43chronic mucocutaneous candidiasis10.2
44pulmonary edema10.2
45arteriovenous malformation10.2
46loeys-dietz syndrome10.2
47arachnoiditis10.2
48aortic aneurysm10.2
49candidiasis10.2
50cranial nerve palsy10.2

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to intracranial aneurysm

Symptoms for Intracranial Aneurysm

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Drugs & Therapeutics for Intracranial Aneurysm

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Drug clinical trials:

Search ClinicalTrials for Intracranial Aneurysm

Search NIH Clinical Center for Intracranial Aneurysm

Genetic Tests for Intracranial Aneurysm

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Anatomical Context for Intracranial Aneurysm

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MalaCards organs/tissues related to Intracranial Aneurysm:

31
Brain, Eye, Heart, Lung, Kidney, Endothelial, Pituitary, Testes, Bone, Spinal cord, Smooth muscle, Liver, Thyroid, Monocytes, T cells

Animal Models for Intracranial Aneurysm or affiliated genes

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MGI Mouse Phenotypes related to Intracranial Aneurysm:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0LOX, PKD1, COL3A1, COL1A2, ENG
2MP:00053887.6ENG, FBN2, LOX, ELN, PKD1, PKD2
3MP:00053767.5LOX, ELANE, ELN, PKD1, PKD2, COL3A1
4MP:00028737.4ELANE, PKD1, PKD2, COL1A2, ENG
5MP:00053787.3ENG, COL1A2, COL3A1, PKD2, PKD1, FBN2
6MP:00053697.2FBN2, LOX, ELN, PKD1, COL3A1, COL1A2
7MP:00053856.8FBN2, LOX, ELN, PKD1, PKD2, COL3A1
8MP:00107686.1FBN2, LOX, ELANE, ELN, PKD1, PKD2

Publications for Intracranial Aneurysm

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Articles related to Intracranial Aneurysm:

(show top 50)    (show all 670)
idTitleAuthorsYear
1
Radiation Dose from 3D Rotational vs. Conventional 2D Digital Subtraction Angiography in Intracranial Aneurysm Coiling. (25857349)
2015
2
Serial Imaging Surveillance for Patients With a History of Intracranial Aneurysm: Risk of De Novo Aneurysm Formation. (25790068)
2015
3
Ruptured intracranial aneurysm during pregnancy with false-negative computed tomography angiography findings: a case report. (25732356)
2015
4
Identification of the soluble form of tyrosine kinase receptor Axl as a potential biomarker for intracranial aneurysm rupture. (25885003)
2015
5
Intracranial aneurysm and diplopia due to oculomotor nerve palsy: pre- and post-operative study. (25203340)
2014
6
Influence of cumulative surgical experience on the outcome of poor-grade patients with ruptured intracranial aneurysm. (25248329)
2014
7
Association between NFKB1 -94 insertion/deletion ATTG polymorphism and risk of intracranial aneurysm. (23675986)
2013
8
Propose a wall shear stress divergence to estimate the risks of intracranial aneurysm rupture. (24191140)
2013
9
Oxidative stress is associated with cell death, wall degradation, and increased risk of rupture of the intracranial aneurysm wall. (23096423)
2013
10
Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture. (23463757)
2013
11
Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment. (23381018)
2013
12
Benefits of 3D rotational DSA compared with 2D DSA in the evaluation of intracranial aneurysm. (22578227)
2012
13
De novo intracranial aneurysm formation following endovascular treatment of giant aneurysm in an infant: case report. (22167265)
2012
14
De novo large fusiform posterior circulation intracranial aneurysm presenting with subarachnoid hemorrhage 7 years after therapeutic internal carotid artery occlusion: case report and review of the literature. (22710380)
2012
15
Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm. (23065210)
2012
16
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. (22286173)
2012
17
Images in vascular medicine. A ruptured intracranial aneurysm with underlying cervicocranial fibromuscular dysplasia. (22006367)
2012
18
Persistent neurological deficit from iodinated contrast encephalopathy following intracranial aneurysm coiling. A case report and review of the literature. (22440599)
2012
19
Increased relative risk of lung cancer in 2,904 patients with saccular intracranial aneurysm disease in eastern Finland. (22343186)
2012
20
Osteogenesis imperfecta, multiple intra-abdominal arterial dissections and a ruptured dissecting-type intracranial aneurysm. (22005702)
2011
21
The rationale and design of the Giant Intracranial Aneurysm Registry: a retrospective and prospective study. (21557815)
2011
22
Time-resolved 3D contrast-enhanced MRA on 3.0T: a non-invasive follow-up technique after stent-assisted coil embolization of the intracranial aneurysm. (22043147)
2011
23
Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. (20706138)
2011
24
Identification of an autosomal dominant locus for intracranial aneurysm through a model-based family collection in a geographically limited area. (21451530)
2011
25
Frequency of intracranial aneurysms in patients with spontaneous intracranial hypotension. (21395391)
2011
26
Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. (20418302)
2010
27
Complete heart block complicating intracranial aneurysm surgery in a pregnant patient. (20228491)
2010
28
Peripheral intracranial aneurysm causing subdural hematoma without subarachnoid hemorrhage. (20083805)
2010
29
Automated intracranial aneurysm isolation and quantification. (21095707)
2010
30
Endovascular treatment of intracranial aneurysms associated with moyamoya disease or moyamoya syndrome. (20977854)
2010
31
Multiplicative impact of smoking and genetic predisposition on intracranial aneurysm formation. (20644401)
2010
32
Association of meningioma and intracranial aneurysm: report of five cases and review of literature. (20139508)
2009
33
Combined endovascular and microsurgical procedures as complementary approaches in the treatment of a single intracranial aneurysm. (19096540)
2008
34
Rupture of intracranial aneurysm after partial clipping due to aspiration drainage system--a case report. (18637618)
2008
35
The interleukin-6 gene -572G>C promoter polymorphism is related to intracranial aneurysms in Chinese Han nationality. (18487018)
2008
36
The role of intraoperative micro-Doppler ultrasound in verifying proper clip placement in intracranial aneurysm surgery. (17981038)
2008
37
Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. (18323491)
2008
38
Association of kallikrein gene polymorphisms with intracranial aneurysms. (17761919)
2007
39
Increased apoptosis and cysteinyl aspartate specific protease-3 gene expression in human intracranial aneurysm. (17430778)
2007
40
The versican gene and the risk of intracranial aneurysms. (16917090)
2006
41
Intracranial aneurysm and carotid artery stenosis. (16866048)
2006
42
Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm. (16574921)
2006
43
Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13. (15540160)
2005
44
BehAset's disease, associated with subarachnoidal heamorrhage due to intracranial aneurysm. (15806330)
2005
45
Correlation between APOA gene polymorphism and intracranial aneurysm]. (15782489)
2005
46
Spontaneous regression of a primary cerebral tumor following vasospasm caused by subarachnoid hemorrhage due to rupture of an intracranial aneurysm--case report. (15185757)
2004
47
Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families. (15273433)
2004
48
Acute vasogenic edema induced by thrombosis of a giant intracranial aneurysm: a cause of pseudostroke after therapeutic occlusion of the parent vessel. (12812962)
2003
49
The influence of hemodynamic stress factors on intracranial aneurysm formation. (11702865)
2001
50
Intracranial aneurysms in Ehlers-Danlos syndrome type IV in early childhood. (11704406)
2001

Variations for Intracranial Aneurysm

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Expression for genes affiliated with Intracranial Aneurysm

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Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for genes affiliated with Intracranial Aneurysm

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Pathways related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ELN, ELANE
29.3COL3A1, COL1A2
39.3COL1A2, COL3A1
49.3COL3A1, COL1A2
5
Show member pathways
9.3COL1A2, COL3A1
6
Show member pathways
9.2ELN, LOX, FBN2
7
Show member pathways
9.0COL1A2, COL3A1, LOX
8
Show member pathways
Metalloproteases in connective tissue degradation
8.9COL1A2, COL3A1, ELN
98.9ELN, COL3A1, COL1A2
10
Show member pathways
8.3COL1A2, COL3A1, ELN, FBN2
11
Show member pathways
8.3FBN2, ELN, COL3A1, COL1A2
12
Show member pathways
8.0FBN2, LIMK1, ELN, COL3A1, COL1A2
13
Show member pathways
7.5COL1A2, FBN2, LOX, ELANE, ELN, COL3A1

Compounds for genes affiliated with Intracranial Aneurysm

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Compounds related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 36)
idCompoundScoreTop Affiliating Genes
1beta-aminopropionitrile4310.2LOX, ELN
2alpha-aminoadipic semialdehyde4310.2ELN, LOX
3hydroxylysine4310.1ELN, LOX
4pentosidine4310.1ELN, LOX
5d penicillamine4310.1ELN, LOX
6pyridinoline4310.1ELN, LOX
7deoxypyridinoline4310.0ELN, LOX
8ethylenediamine4310.0LOX, ELANE
9isodesmosine4310.0ELN, ELANE
10tannins439.9ELANE, ELN
11(4-aminophenyl)mercuric acetate439.9ELN, ELANE
12trp-p-2439.9PKD2, PKD1
13thermolysin439.9ELANE, ELN
14beta-lactam439.8ELANE, PKD1
15diisopropylfluorophosphate439.8ELN, ELANE
16nppa439.7COL3A1, COL1A2
17desmosine439.7ELN, ELANE, LOX
18alginate439.6ELN, ELANE
19nppb28 43 5911.6COL1A2, COL3A1
20carbon439.6LOX, ELANE, ELN
21dermatan sulfate439.6ELN, ELANE
22doxycycline43 1210.6ELN, ELANE
23ascorbic acid43 2410.6LOX, ELN, ENG
24cyanogen bromide439.6ELN, COL1A2
25valine439.6ELN, ELANE, LOX
26hyaluronic acid43 2410.5ENG, ELN, ELANE
27hydroxyproline43 24 1211.5ELN, LOX
28paraffin439.3LOX, ELN, ENG
29procollagen439.0LOX, ELN, COL3A1, COL1A2
30chloramphenicol43 2 49 1212.0ELANE, ELN, COL1A2
31glutamate438.9COL3A1, PKD1, ELN, ELANE
32vitamin d438.9ELANE, ELN, COL1A2
33estrogen438.4LOX, ELANE, ELN, COL1A2, ENG
34tyrosine438.2LIMK1, LOX, PKD1, COL1A2, ENG
35serine437.9LIMK1, ELANE, ELN, PKD1, COL1A2, ENG
36cysteine437.8FBN2, LOX, ELANE, ELN, COL1A2, ENG

GO Terms for genes affiliated with Intracranial Aneurysm

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Cellular components related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:00021339.5PKD2, PKD1
2motile primary ciliumGO:00315129.2PKD2, PKD1
3extracellular spaceGO:00056158.6ENG, COL1A2, COL3A1, LOX
4extracellular regionGO:00055767.4FBN2, LOX, ELANE, ELN, COL3A1, COL1A2

Biological processes related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1mesonephric tubule developmentGO:00721649.8PKD2, PKD1
2metanephric ascending thin limb developmentGO:00722189.8PKD2, PKD1
3mesonephric duct developmentGO:00721779.8PKD2, PKD1
4positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:00316599.8PKD2, PKD1
5placenta blood vessel developmentGO:00606749.8PKD1, PKD2
6detection of mechanical stimulusGO:00509829.8PKD2, PKD1
7digestive tract developmentGO:00485659.8COL3A1, PKD1
8cytoplasmic sequestering of transcription factorGO:00429949.8PKD2, PKD1
9wound healingGO:00420609.7LOX, COL3A1, ENG
10spinal cord developmentGO:00215109.7PKD2, PKD1
11neural tube developmentGO:00219159.7PKD2, PKD1
12skin developmentGO:00435889.7COL3A1, PKD1
13embryonic placenta developmentGO:00018929.7PKD1, PKD2
14JAK-STAT cascadeGO:00072599.6PKD2, PKD1
15calcium ion transmembrane transportGO:00705889.5PKD2, PKD1
16heart developmentGO:00075079.4PKD1, PKD2, COL3A1
17collagen fibril organizationGO:00301999.3LOX, COL3A1, COL1A2
18blood vessel developmentGO:00015689.3LOX, COL3A1, COL1A2
19heart loopingGO:00019479.3ENG, PKD2
20cellular response to amino acid stimulusGO:00712309.3COL3A1, COL1A2
21Rho protein signal transductionGO:00072669.3COL1A2, LIMK1
22transforming growth factor beta receptor signaling pathwayGO:00071799.2ENG, COL1A2, COL3A1
23collagen catabolic processGO:00305749.1COL1A2, COL3A1, ELANE
24extracellular matrix organizationGO:00301987.8FBN2, LOX, ELANE, ELN, COL3A1, COL1A2
25extracellular matrix disassemblyGO:00226177.7ENG, COL1A2, COL3A1, ELN, ELANE, FBN2

Molecular functions related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SMAD bindingGO:00463329.3COL1A2, COL3A1
2platelet-derived growth factor bindingGO:00484079.0COL1A2, COL3A1
3extracellular matrix structural constituentGO:00052018.3COL1A2, COL3A1, ELN, FBN2
4protein bindingGO:00055156.3LIMK1, LOX, ELANE, ELN, PKD1, PKD2

Products for genes affiliated with Intracranial Aneurysm

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Sources for Intracranial Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet