MCID: INT030
MIFTS: 56

Intracranial Aneurysm malady

Cardiovascular diseases, Neuronal diseases, Rare diseases categories
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Summaries for Intracranial Aneurysm

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MedlinePlus:33 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

MalaCards based summary: Intracranial Aneurysm, also known as brain aneurysm, is related to polycystic kidney disease and aneurysm. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Calcium channels. The compounds beta-aminopropionitrile and alpha-aminoadipic semialdehyde have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related mouse phenotypes are integument and respiratory system.

NINDS:43 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

Wikipedia:65 An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which... more...

Aliases & Classifications for Intracranial Aneurysm

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Intracranial Aneurysm, Aliases & Descriptions:

Name: Intracranial Aneurysm 8 10 44 62
 
Brain Aneurysm 8 43 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:10941
MeSH34 D002532
SNOMED-CT57 42994005, 128609009
NCIt39 C34458

Related Diseases for Intracranial Aneurysm

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Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic kidney disease31.0PKD2, PKD1
2aneurysm30.8ELN, ELANE, LOX, FBN2, PKD1, PKD2
3cerebral aneurysms30.6ELANE, ELN, PKD1
4abdominal aortic aneurysm30.5ELANE, ELN
5ehlers-danlos syndrome type iv30.5ELN, COL3A1
6ehlers-danlos syndrome30.4ELANE, ELN
7polycystic liver disease30.3PKD2, PKD1
8osteogenesis imperfecta30.1COL3A1, COL1A2
9polycystic kidney disease, autosomal dominant30.1PKD1, PKD2
10connective tissue disease29.0COL1A2, COL3A1, PKD1, ELN, LOX, FBN2
11cerebritis10.7
12endotheliitis10.5
13kidney disease10.5
14occipital horn syndrome10.5LOX
15hypertension10.5
16carotid stenosis10.4
17fibromuscular dysplasia10.4
18emphysema due to aat deficiency10.4ELANE
19tuberous sclerosis10.4
20ischemia10.4
21supravalvular aortic stenosis10.3ELN, LIMK1
22menkes disease10.3LOX, ELN
23williams syndrome10.3LIMK1, ELN
24telangiectasis10.3ENG, ELN
25endometriosis10.3ENG, ELN
26alpha 1-antitrypsin deficiency10.2
27carotid artery occlusion10.2
28moyamoya disease10.2
29tuberous sclerosis complex10.2
30headache10.2
31thromboembolism10.2
32blindness10.2
33keloids10.2ELN, LOX
34polycystic kidney disease, type 210.2PKD1, PKD2
35adult respiratory distress syndrome10.2ELANE, ELN
36nephronophthisis10.2PKD1, PKD2
37pulmonary emphysema10.2ELANE, ELN
38polycystic kidney disease, autosomal recessive10.2PKD1, PKD2
39williams-beuren syndrome10.2LIMK1, ELN
40arteriovenous fistula10.2
41progressive hemifacial atrophy10.2
42loeys-dietz syndrome10.2
43klippel-trenaunay syndrome10.2
44chronic mucocutaneous candidiasis10.2
45panhypopituitarism10.2
46carotid artery dissection10.2
47polyarteritis nodosa10.2
48cortical blindness10.2
49arachnoiditis10.2
50pulmonary edema10.2

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to intracranial aneurysm

Symptoms for Intracranial Aneurysm

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Drugs & Therapeutics for Intracranial Aneurysm

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Drug clinical trials:

Search ClinicalTrials for Intracranial Aneurysm

Search NIH Clinical Center for Intracranial Aneurysm

Genetic Tests for Intracranial Aneurysm

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Anatomical Context for Intracranial Aneurysm

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MalaCards organs/tissues related to Intracranial Aneurysm:

32
Brain, Eye, Heart, Lung, Endothelial, Kidney, Pituitary, Testes, Bone, Spinal cord, Smooth muscle, Liver, Thyroid, Monocytes, T cells

Animal Models for Intracranial Aneurysm or affiliated genes

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MGI Mouse Phenotypes related to Intracranial Aneurysm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0LOX, PKD1, COL3A1, COL1A2, ENG
2MP:00053887.6ENG, FBN2, LOX, ELN, PKD1, PKD2
3MP:00053767.5LOX, ELANE, ELN, PKD1, PKD2, COL3A1
4MP:00028737.4ELANE, PKD1, PKD2, COL1A2, ENG
5MP:00053787.3ENG, COL1A2, COL3A1, PKD2, PKD1, FBN2
6MP:00053697.2FBN2, LOX, ELN, PKD1, COL3A1, COL1A2
7MP:00053856.8FBN2, LOX, ELN, PKD1, PKD2, COL3A1
8MP:00107686.1FBN2, LOX, ELANE, ELN, PKD1, PKD2

Publications for Intracranial Aneurysm

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Articles related to Intracranial Aneurysm:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
Intracranial aneurysm and diplopia due to oculomotor nerve palsy: pre- and post-operative study. (25203340)
2014
2
Influence of cumulative surgical experience on the outcome of poor-grade patients with ruptured intracranial aneurysm. (25248329)
2014
3
Association between NFKB1 -94 insertion/deletion ATTG polymorphism and risk of intracranial aneurysm. (23675986)
2013
4
Propose a wall shear stress divergence to estimate the risks of intracranial aneurysm rupture. (24191140)
2013
5
Oxidative stress is associated with cell death, wall degradation, and increased risk of rupture of the intracranial aneurysm wall. (23096423)
2013
6
Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture. (23463757)
2013
7
Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment. (23381018)
2013
8
Extracorporeal membrane oxygenation for acute life-threatening neurogenic pulmonary edema following rupture of an intracranial aneurysm. (23772167)
2013
9
Benefits of 3D rotational DSA compared with 2D DSA in the evaluation of intracranial aneurysm. (22578227)
2012
10
De novo intracranial aneurysm formation following endovascular treatment of giant aneurysm in an infant: case report. (22167265)
2012
11
De novo large fusiform posterior circulation intracranial aneurysm presenting with subarachnoid hemorrhage 7 years after therapeutic internal carotid artery occlusion: case report and review of the literature. (22710380)
2012
12
Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm. (23065210)
2012
13
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. (22286173)
2012
14
Images in vascular medicine. A ruptured intracranial aneurysm with underlying cervicocranial fibromuscular dysplasia. (22006367)
2012
15
Persistent neurological deficit from iodinated contrast encephalopathy following intracranial aneurysm coiling. A case report and review of the literature. (22440599)
2012
16
Increased relative risk of lung cancer in 2,904 patients with saccular intracranial aneurysm disease in eastern Finland. (22343186)
2012
17
Osteogenesis imperfecta, multiple intra-abdominal arterial dissections and a ruptured dissecting-type intracranial aneurysm. (22005702)
2011
18
The rationale and design of the Giant Intracranial Aneurysm Registry: a retrospective and prospective study. (21557815)
2011
19
Time-resolved 3D contrast-enhanced MRA on 3.0T: a non-invasive follow-up technique after stent-assisted coil embolization of the intracranial aneurysm. (22043147)
2011
20
Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. (20706138)
2011
21
Identification of an autosomal dominant locus for intracranial aneurysm through a model-based family collection in a geographically limited area. (21451530)
2011
22
Frequency of intracranial aneurysms in patients with spontaneous intracranial hypotension. (21395391)
2011
23
Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. (20418302)
2010
24
Complete heart block complicating intracranial aneurysm surgery in a pregnant patient. (20228491)
2010
25
Peripheral intracranial aneurysm causing subdural hematoma without subarachnoid hemorrhage. (20083805)
2010
26
Automated intracranial aneurysm isolation and quantification. (21095707)
2010
27
Endovascular treatment of intracranial aneurysms associated with moyamoya disease or moyamoya syndrome. (20977854)
2010
28
Multiplicative impact of smoking and genetic predisposition on intracranial aneurysm formation. (20644401)
2010
29
Hemodynamic relationship between intracranial aneurysm and carotid stenosis: review of clinical cases and numerical analyses. (20444325)
2010
30
Association of meningioma and intracranial aneurysm: report of five cases and review of literature. (20139508)
2009
31
The role of collagen type I alpha2 polymorphisms: intracranial aneurysms in Koreans. (19559927)
2009
32
Combined endovascular and microsurgical procedures as complementary approaches in the treatment of a single intracranial aneurysm. (19096540)
2008
33
Rupture of intracranial aneurysm after partial clipping due to aspiration drainage system--a case report. (18637618)
2008
34
The interleukin-6 gene -572G>C promoter polymorphism is related to intracranial aneurysms in Chinese Han nationality. (18487018)
2008
35
The role of intraoperative micro-Doppler ultrasound in verifying proper clip placement in intracranial aneurysm surgery. (17981038)
2008
36
Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. (18323491)
2008
37
Association of kallikrein gene polymorphisms with intracranial aneurysms. (17761919)
2007
38
Increased apoptosis and cysteinyl aspartate specific protease-3 gene expression in human intracranial aneurysm. (17430778)
2007
39
The versican gene and the risk of intracranial aneurysms. (16917090)
2006
40
Intracranial aneurysm and carotid artery stenosis. (16866048)
2006
41
Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm. (16574921)
2006
42
Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13. (15540160)
2005
43
BehAset's disease, associated with subarachnoidal heamorrhage due to intracranial aneurysm. (15806330)
2005
44
Correlation between APOA gene polymorphism and intracranial aneurysm]. (15782489)
2005
45
Spontaneous regression of a primary cerebral tumor following vasospasm caused by subarachnoid hemorrhage due to rupture of an intracranial aneurysm--case report. (15185757)
2004
46
Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families. (15273433)
2004
47
Acute vasogenic edema induced by thrombosis of a giant intracranial aneurysm: a cause of pseudostroke after therapeutic occlusion of the parent vessel. (12812962)
2003
48
Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. (12750963)
2003
49
The influence of hemodynamic stress factors on intracranial aneurysm formation. (11702865)
2001
50
Alkaptonuric ochronosis and multiple intracranial aneurysms. (2315833)
1990

Variations for Intracranial Aneurysm

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Expression for genes affiliated with Intracranial Aneurysm

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Expression patterns in normal tissues for genes affiliated with Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for genes affiliated with Intracranial Aneurysm

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Pathways related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ELN, ELANE
29.5PKD2, PKD1
39.3COL3A1, COL1A2
49.3COL1A2, COL3A1
59.3COL3A1, COL1A2
6
Show member pathways
9.3COL1A2, COL3A1
7
Show member pathways
9.2ELN, LOX, FBN2
8
Show member pathways
9.0COL1A2, COL3A1, LOX
9
Show member pathways
8.9COL1A2, COL3A1, ELN
108.9ELN, COL3A1, COL1A2
11
Show member pathways
8.3COL1A2, COL3A1, ELN, FBN2
12
Show member pathways
8.3FBN2, ELN, COL3A1, COL1A2
13
Show member pathways
8.0FBN2, LIMK1, ELN, COL3A1, COL1A2
14
Show member pathways
7.5COL1A2, FBN2, LOX, ELANE, ELN, COL3A1

Compounds for genes affiliated with Intracranial Aneurysm

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Compounds related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1beta-aminopropionitrile4410.2LOX, ELN
2alpha-aminoadipic semialdehyde4410.2ELN, LOX
3hydroxylysine4410.1ELN, LOX
4pentosidine4410.1ELN, LOX
5d penicillamine4410.1ELN, LOX
6pyridinoline4410.1ELN, LOX
7deoxypyridinoline4410.0ELN, LOX
8ethylenediamine4410.0LOX, ELANE
9isodesmosine4410.0ELN, ELANE
10tannins449.9ELANE, ELN
11(4-aminophenyl)mercuric acetate449.9ELN, ELANE
12trp-p-2449.9PKD2, PKD1
13thermolysin449.9ELANE, ELN
14beta-lactam449.8ELANE, PKD1
15diisopropylfluorophosphate449.8ELN, ELANE
16nppa449.7COL3A1, COL1A2
17desmosine449.7ELN, ELANE, LOX
18alginate449.6ELN, ELANE
19nppb28 44 6111.6COL1A2, COL3A1
20carbon449.6LOX, ELANE, ELN
21dermatan sulfate449.6ELN, ELANE
22doxycycline44 1110.6ELN, ELANE
23ascorbic acid44 2410.6LOX, ELN, ENG
24cyanogen bromide449.6ELN, COL1A2
25valine449.6ELN, ELANE, LOX
26hyaluronic acid44 2410.5ENG, ELN, ELANE
27hydroxyproline44 24 1111.5ELN, LOX
28paraffin449.3LOX, ELN, ENG
29procollagen449.0LOX, ELN, COL3A1, COL1A2
30chloramphenicol44 2 50 1112.0ELANE, ELN, COL1A2
31glutamate448.9COL3A1, PKD1, ELN, ELANE
32vitamin d448.9ELANE, ELN, COL1A2
33estrogen448.4LOX, ELANE, ELN, COL1A2, ENG
34tyrosine448.2LIMK1, LOX, PKD1, COL1A2, ENG
35serine447.9LIMK1, ELANE, ELN, PKD1, COL1A2, ENG
36cysteine447.8FBN2, LOX, ELANE, ELN, COL1A2, ENG

GO Terms for genes affiliated with Intracranial Aneurysm

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Cellular components related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:0021339.5PKD2, PKD1
2motile primary ciliumGO:0315129.2PKD2, PKD1
3extracellular spaceGO:0056158.6ENG, COL1A2, COL3A1, LOX
4extracellular regionGO:0055767.4FBN2, LOX, ELANE, ELN, COL3A1, COL1A2

Biological processes related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1mesonephric tubule developmentGO:0721649.8PKD2, PKD1
2metanephric ascending thin limb developmentGO:0722189.8PKD2, PKD1
3mesonephric duct developmentGO:0721779.8PKD2, PKD1
4positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:0316599.8PKD2, PKD1
5placenta blood vessel developmentGO:0606749.8PKD1, PKD2
6detection of mechanical stimulusGO:0509829.8PKD2, PKD1
7digestive tract developmentGO:0485659.8COL3A1, PKD1
8cytoplasmic sequestering of transcription factorGO:0429949.8PKD2, PKD1
9wound healingGO:0420609.7LOX, COL3A1, ENG
10spinal cord developmentGO:0215109.7PKD2, PKD1
11neural tube developmentGO:0219159.7PKD2, PKD1
12skin developmentGO:0435889.7COL3A1, PKD1
13embryonic placenta developmentGO:0018929.7PKD1, PKD2
14JAK-STAT cascadeGO:0072599.6PKD2, PKD1
15calcium ion transmembrane transportGO:0705889.5PKD2, PKD1
16heart developmentGO:0075079.4PKD1, PKD2, COL3A1
17collagen fibril organizationGO:0301999.3LOX, COL3A1, COL1A2
18blood vessel developmentGO:0015689.3LOX, COL3A1, COL1A2
19heart loopingGO:0019479.3ENG, PKD2
20cellular response to amino acid stimulusGO:0712309.3COL3A1, COL1A2
21Rho protein signal transductionGO:0072669.3COL1A2, LIMK1
22transforming growth factor beta receptor signaling pathwayGO:0071799.2ENG, COL1A2, COL3A1
23collagen catabolic processGO:0305749.1COL1A2, COL3A1, ELANE
24extracellular matrix organizationGO:0301987.8FBN2, LOX, ELANE, ELN, COL3A1, COL1A2
25extracellular matrix disassemblyGO:0226177.7ENG, COL1A2, COL3A1, ELN, ELANE, FBN2

Molecular functions related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD bindingGO:0463329.3COL1A2, COL3A1
2platelet-derived growth factor bindingGO:0484079.0COL1A2, COL3A1
3extracellular matrix structural constituentGO:0052018.3COL1A2, COL3A1, ELN, FBN2
4protein bindingGO:0055156.3LIMK1, LOX, ELANE, ELN, PKD1, PKD2

Products for genes affiliated with Intracranial Aneurysm

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Sources for Intracranial Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet