MCID: INT030
MIFTS: 56

Intracranial Aneurysm malady

Neuronal diseases category

Summaries for Intracranial Aneurysm

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

MalaCards: Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm disease and polycystic kidney disease. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Rho Family GTPases and Cell adhesion ECM remodeling. The compounds desmosine and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related mouse phenotypes are respiratory system and muscle.

NINDS:43 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

Wikipedia:63 An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which... more...

Aliases & Classifications for Intracranial Aneurysm

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 43NINDS, 33MedlinePlus, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

intracranial aneurysm 8 10 44 60
brain aneurysm 8 43 44 33 60
intracranial aneurysm, nos 8


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Disease Ontology8 DOID:10941
NCIt39 C34458
SNOMED-CT56 128609009, 42994005
MeSH34 D002532

Related Diseases for Intracranial Aneurysm

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17GeneCards, 18GeneDecks
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Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm disease31.0LOX, ELANE, ENG, SERPINA1, PKD1, PKD2
2polycystic kidney disease30.7PKD2, PKD1
3hypertension30.6NOS3, ACE2
4polycystic kidney disease, autosomal dominant30.6PKD2, PKD1, NOS3
5ischemia30.4ENG, NOS3
6alpha 1-antitrypsin deficiency30.3SERPINA1, ELANE
7ehlers-danlos syndrome type iv30.2ELN, COL3A1
8ehlers-danlos syndrome30.2ELN, ELANE
9connective tissue disease29.9FBN2, PKD1, ELN, COL3A1, COL1A2, LOX
10myocardial infarction29.9ACE2, ENG, NOS3, COL3A1
11osteogenesis imperfecta29.9COL1A2, COL3A1
12polycystic liver disease29.9PKD2, PKD1
13intracranial embolism10.8
14cerebritis10.7
15kidney disease10.5
16intracranial vasospasm10.4
17carotid stenosis10.4
18autosomal dominant disease10.4
19intracranial hypertension10.4
20aortic aneurysm10.4
21intracranial thrombosis10.4
22tuberous sclerosis10.3
23moyamoya disease10.3
24klippel-trenaunay syndrome10.2
25carotid artery dissection10.2
26abdominal aortic aneurysm10.2
27carotid artery occlusion10.2
28cervicitis10.2
29arteriovenous fistula10.1
30pulmonary edema10.1
31arteriovenous malformation10.1
32loeys-dietz syndrome10.1
33arachnoiditis10.1
34intracranial hypotension10.1
35panhypopituitarism10.1
36polyarteritis nodosa10.1
37cortical blindness10.1
38chronic mucocutaneous candidiasis10.1
39candidiasis10.1
40cranial nerve palsy10.1
41hemorrhagic disease10.1
42meningitis10.1
43migraine10.1
44multiple sclerosis10.1
45fibromuscular dysplasia10.1
46intracranial aneurysms multiple congenital anomaly10.1
47marfan syndrome10.0FBN2, COL3A1, LOX, PKD1, ELN, COL1A2
48systemic scleroderma10.0NOS3, ENG, LOX, COL3A1, COL1A2
49atherosclerosis10.0ELANE, LOX, ELN, NOS3
50cerebral aneurysms10.0ELANE, PKD1, ELN

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to intracranial aneurysm

Clinical Features for Intracranial Aneurysm

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Drugs & Therapeutics for Intracranial Aneurysm

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intracranial Aneurysm

Drug clinical trials:

Search ClinicalTrials for Intracranial Aneurysm

Search NIH Clinical Center for Intracranial Aneurysm

Search CenterWatch for Intracranial Aneurysm

Genetic Tests for Intracranial Aneurysm

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Anatomical Context for Intracranial Aneurysm

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32MalaCards
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MalaCards organs/tissues related to Intracranial Aneurysm:

32
Brain, Heart, Eye, Lung, Endothelial, Kidney, Pituitary, Bone, Testes, Smooth muscle, Spinal cord, Thyroid, Monocytes, Liver

Animal Models for Intracranial Aneurysm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intracranial Aneurysm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.6ELN, LOX, COL3A1, FBN2, PKD2, PKD1
2MP:000536910.5LOX, COL1A2, COL3A1, FBN2, PKD1, NOS3
3MP:000287310.5SOX17, PKD2, PKD1, NOS3, ENG, ELANE
4MP:000538510.4LOX, COL1A2, COL3A1, FBN2, PKD2, PKD1
5MP:001076810.2FBN2, SOX17, COL3A1, COL1A2, LOX, PKD2

Publications for Intracranial Aneurysm

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50PubMed
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Articles related to Intracranial Aneurysm:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Use of indocyanine green videoangiography during intracranial aneurysm surgery reduces the incidence of postoperative ischaemic complications. (24090515)
2014
2
Oxidative stress is associated with cell death, wall degradation, and increased risk of rupture of the intracranial aneurysm wall. (23096423)
2013
3
Endovascular methods for the treatment of intracranial cerebral aneurysms. (24156851)
2013
4
Health-related quality of life 10 years after intracranial aneurysm rupture: a retrospective cohort study using EQ-5D. (23208056)
2013
5
Giant intracranial aneurysm embolization with a yield stress fluid material: insights from CFD analysis. (23863277)
2013
6
Aneurysmal bone cyst within fibrous dysplasia of the anterior skull base: continued intracranial extension after endoscopic resections requiring craniofacial approach with free tissue transfer reconstruction. (23435492)
2013
7
Intracranial aneurysm and recessive polycystic kidney disease: the third reported case. (23318517)
2013
8
Investigation of intracranial aneurysm hemodynamics following flow diverter stent treatment. (22884174)
2013
9
Prediction of shape diameter undergoing coil embolization of saccular intracranial aneurysm treatment using a hybrid decision support system. (23605241)
2013
10
On the role of screening for intracranial aneurysms in autosomal dominant polycystic kidney disease. (23436055)
2013
11
Microsurgical Management of Giant Intracranial Aneurysm: A Single Surgeon Experience from Louisiana State University, Shreveport. (23246634)
2012
12
Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. (22961961)
2012
13
The transforming growth factor-I^ receptor genes and the risk of intracranial aneurysms. (21978186)
2012
14
Intraoperative mild hypothermia for postoperative neurological deficits in intracranial aneurysm patients. (22336843)
2012
15
Treatment of pediatric patient with ruptured intracranial aneurysm--case report. (22924255)
2012
16
Endoscopic view of sphenoid sinusitis adjacent to an intracranial aneurysm. (22829045)
2012
17
Identification of an autosomal dominant locus for intracranial aneurysm through a model-based family collection in a geographically limited area. (21451530)
2011
18
Frequency of intracranial aneurysms in patients with spontaneous intracranial hypotension. (21395391)
2011
19
Increased rate of intracranial saccular aneurysms in acromegaly: an MR angiography study and review of the literature. (21307138)
2011
20
Association of acute onset hypertension and tachycardia following intracisternal papaverine administration during intracranial aneurysm surgery: a case report and review of the literature. (21497075)
2011
21
Intracranial aneurysm segmentation in 3D CT angiography: method and quantitative validation with and without prior noise filtering. (20346606)
2011
22
Unruptured intracranial aneurysm as a cause of cerebral ischemia. (20926179)
2011
23
Combined treatment with stenting and coiling for complex cerebral aneurysms: preliminary experience of twenty aneurysms treated by new generation intracranial stents. (24148541)
2010
24
Small unruptured intracranial aneurysm verification study: SUAVe study, Japan. (20671254)
2010
25
A 10-year follow-up of extracranial-intracranial bypass for the treatment of bilateral giant internal carotid artery aneurysms in a patient with fibromuscular dysplasia: case report. (20734090)
2010
26
Clinical presentation and outcomes of coil embolization of remnant or recurred intracranial aneurysm after clipping. (20495427)
2010
27
A role for inflammation in intracranial aneurysm pathophysiology? (20495410)
2010
28
Mechanical design of an intracranial stent for treating cerebral aneurysms. (20675176)
2010
29
A modified technique improved histology similarity to human intracranial aneurysm in rabbit aneurysm model. (24148684)
2010
30
Relevance of intracranial hypertension for cerebral metabolism in aneurysmal subarachnoid hemorrhage. Clinical article. (19284237)
2009
31
Association of meningioma and intracranial aneurysm: report of five cases and review of literature. (20139508)
2009
32
Therapeutic hypothermia in patients with aneurysmal subarachnoid hemorrhage, refractory intracranial hypertension, or cerebral vasospasm. (19050656)
2009
33
Recurrent subarachnoid hemorrhage after complete obliteration of intracranial aneurysm. (20041062)
2009
34
Anticoagulation in a Neurosurgical Patient with Heparin-Induced Thrombocytopenia Type II with Argatroban and Fondaparinux after Clipping of an Intracranial Aneurysm. (20823996)
2009
35
Intracranial aneurysm enlargement on serial magnetic resonance angiography: frequency and risk factors. (19023101)
2009
36
TEE for managing a patient with mitral valve disease undergoing clipping of intracranial aneurysm. (19098635)
2009
37
Emergency extra-intracranial bypass surgery in the treatment of cerebral aneurysms. (18496952)
2008
38
Immediate intracranial aneurysm occlusion after embolization with detachable coils: a comparison between MR angiography and intra-arterial digital subtraction angiography. (17582496)
2007
39
Endothelial injury and inflammatory response induced by hemodynamic changes preceding intracranial aneurysm formation: experimental study in rats. (17695397)
2007
40
Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients. (17121133)
2006
41
The Familial Intracranial Aneurysm (FIA) study protocol. (15854227)
2005
42
Prospective risk of hemorrhage in patients with vertebrobasilar nonsaccular intracranial aneurysm. (15255255)
2004
43
Biomathematical modeling and analysis of blood flow in an intracranial aneurysm. (12866198)
2003
44
Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. (14605322)
2003
45
Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms. (13130177)
2003
46
Combined endovascular treatment for both intracranial aneurysm and symptomatic vasospasm. (12533342)
2003
47
Search for intracranial aneurysm susceptibility gene(s) using Finnish families. (12153705)
2002
48
Intracranial aneurysm and vasculopathy after surgery and radiation therapy for craniopharyngioma: case report. (11904045)
2002
49
Partially clipped intracranial aneurysm obliterated with combined stent and coil implantation. (12010094)
2002
50
Cranial aneurysmal bone cysts presenting with raised intracranial pressure: report of two cases. (9258925)
1997

Genetic Variations for Intracranial Aneurysm

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Expression for genes affiliated with Intracranial Aneurysm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for genes affiliated with Intracranial Aneurysm

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51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Intracranial Aneurysm

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1desmosine4410.9ELN, ELANE, SERPINA1, LOX
2ascorbic acid44 2411.9LOX, NOS3, SERPINA1, ENG, ELN
3procollagen4410.9COL1A2
4estrogen4410.9LOX, COL1A2, NOS3, SERPINA1, ENG, ELANE
5trp-p-24410.9PKD2, PKD1
6isodesmosine4410.9ELANE, ELN
7diisopropylfluorophosphate4410.8SERPINA1, ELANE, ELN
8beta-aminopropionitrile4410.8LOX, ELN
9cysteine4410.8LOX, COL1A2, FBN2, SERPINA1, ENG, ELANE
10Collagenase1110.8COL1A2, COL3A1
11alpha-aminoadipic semialdehyde4410.8LOX, ELN
12serine4410.8COL1A2, PKD1, LIMK1, NOS3, SERPINA1, ENG
13nppa4410.8COL1A2, COL3A1
14ethylenediamine4410.8LOX, ELANE
15hydroxylysine4410.8ELN, LOX
16beta-lactam4410.8PKD1, ELANE
17bleomycin44 1111.8LOX, NOS3, ELN
18oxygen44 2411.8LOX, ACE2, SERPINA1, ENG, ELANE
19pentosidine4410.7ELN, LOX
20h2o24410.7LOX, NOS3, SERPINA1, ELANE, ELN
21vitamin d4410.7COL1A2, NOS3, ELANE, ELN
22onoo4410.7SERPINA1, NOS3
23tannins4410.7ELN, ELANE
24(4-aminophenyl)mercuric acetate4410.6ELANE
25sodium dodecylsulfate4410.6ELN, ELANE, NOS3
26nppb44 59 2812.5COL1A2, COL3A1
27d penicillamine4410.5LOX, ELN
28hocl4410.5ELANE, SERPINA1
29sodium nitroprusside4410.4ELN, ELANE, NOS3
30thermolysin4410.2ELN, ELANE

GO Terms for genes affiliated with Intracranial Aneurysm

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16Gene Ontology
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Cellular components related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:00213310.5PKD1, PKD2
2motile primary ciliumGO:03151210.5PKD1, PKD2
3extracellular regionGO:00557610.4LOX, COL1A2, COL3A1, FBN2, ACE2, SERPINA1
4extracellular spaceGO:00561510.2LOX, COL1A2, COL3A1, ACE2, SERPINA1, ENG

Biological processes related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.8ELN, LOX, COL1A2, COL3A1, FBN2, ELANE
2extracellular matrix disassemblyGO:02261710.8ELANE, ENG, COL3A1, COL1A2
3collagen fibril organizationGO:03019910.8LOX, COL1A2, COL3A1
4blood vessel developmentGO:00156810.8COL3A1, COL1A2, LOX
5metanephric ascending thin limb developmentGO:07221810.7PKD2, PKD1
6mesonephric tubule developmentGO:07216410.7PKD2, PKD1
7heart loopingGO:00194710.7ENG, PKD2, SOX17
8mesonephric duct developmentGO:07217710.7PKD2, PKD1
9wound healingGO:04206010.7ENG, COL3A1, LOX
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165910.7PKD1, PKD2
11collagen catabolic processGO:03057410.6COL1A2, COL3A1, ELANE
12placenta blood vessel developmentGO:06067410.6PKD1, PKD2
13detection of mechanical stimulusGO:05098210.5PKD2, PKD1
14transforming growth factor beta receptor signaling pathwayGO:00717910.5ENG, COL3A1, COL1A2
15cytoplasmic sequestering of transcription factorGO:04299410.5PKD1, PKD2
16regulation of cell proliferationGO:04212710.4PKD2, ACE2, ENG
17spinal cord developmentGO:02151010.2PKD1, PKD2

Molecular functions related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.5COL3A1, COL1A2
2extracellular matrix structural constituentGO:00520110.2ELN, FBN2, COL3A1, COL1A2

Products for genes affiliated with Intracranial Aneurysm

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Sources for Intracranial Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet