MCID: INT030
MIFTS: 56

Intracranial Aneurysm malady

Neuronal diseases category

Summaries for Intracranial Aneurysm

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

MalaCards: Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm disease and polycystic kidney disease. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Rho Family GTPases and Cell adhesion ECM remodeling. The compounds desmosine and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related mouse phenotypes are respiratory system and muscle.

NINDS:43 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

Wikipedia:63 An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which... more...

Aliases & Classifications for Intracranial Aneurysm

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 43NINDS, 33MedlinePlus, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

intracranial aneurysm 8 10 44 60
brain aneurysm 8 43 44 33 60
intracranial aneurysm, nos 8


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Disease Ontology8 DOID:10941
NCIt39 C34458
SNOMED-CT56 128609009, 42994005
MeSH34 D002532

Related Diseases for Intracranial Aneurysm

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17GeneCards, 18GeneDecks
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Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm disease31.0LOX, ELANE, ENG, SERPINA1, PKD1, PKD2
2polycystic kidney disease30.7PKD2, PKD1
3hypertension30.6NOS3, ACE2
4polycystic kidney disease, autosomal dominant30.6PKD2, PKD1, NOS3
5ischemia30.4ENG, NOS3
6alpha 1-antitrypsin deficiency30.3SERPINA1, ELANE
7ehlers-danlos syndrome type iv30.2ELN, COL3A1
8ehlers-danlos syndrome30.2ELN, ELANE
9connective tissue disease29.9FBN2, PKD1, ELN, COL3A1, COL1A2, LOX
10myocardial infarction29.9ACE2, ENG, NOS3, COL3A1
11osteogenesis imperfecta29.9COL1A2, COL3A1
12polycystic liver disease29.9PKD2, PKD1
13intracranial embolism10.8
14cerebritis10.7
15kidney disease10.5
16intracranial vasospasm10.4
17carotid stenosis10.4
18autosomal dominant disease10.4
19intracranial hypertension10.4
20aortic aneurysm10.4
21intracranial thrombosis10.4
22tuberous sclerosis10.3
23moyamoya disease10.3
24klippel-trenaunay syndrome10.2
25carotid artery dissection10.2
26abdominal aortic aneurysm10.2
27carotid artery occlusion10.2
28cervicitis10.2
29arteriovenous fistula10.1
30pulmonary edema10.1
31arteriovenous malformation10.1
32loeys-dietz syndrome10.1
33arachnoiditis10.1
34intracranial hypotension10.1
35panhypopituitarism10.1
36polyarteritis nodosa10.1
37cortical blindness10.1
38chronic mucocutaneous candidiasis10.1
39candidiasis10.1
40cranial nerve palsy10.1
41hemorrhagic disease10.1
42meningitis10.1
43migraine10.1
44multiple sclerosis10.1
45fibromuscular dysplasia10.1
46intracranial aneurysms multiple congenital anomaly10.1
47marfan syndrome10.0FBN2, COL3A1, LOX, PKD1, ELN, COL1A2
48systemic scleroderma10.0NOS3, ENG, LOX, COL3A1, COL1A2
49atherosclerosis10.0ELANE, LOX, ELN, NOS3
50cerebral aneurysms10.0ELANE, PKD1, ELN

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to intracranial aneurysm

Clinical Features for Intracranial Aneurysm

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Drugs & Therapeutics for Intracranial Aneurysm

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intracranial Aneurysm

Drug clinical trials:

Search ClinicalTrials for Intracranial Aneurysm

Search NIH Clinical Center for Intracranial Aneurysm

Search CenterWatch for Intracranial Aneurysm

Genetic Tests for Intracranial Aneurysm

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Anatomical Context for Intracranial Aneurysm

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32MalaCards
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MalaCards organs/tissues related to Intracranial Aneurysm:

32
Brain, Heart, Eye, Lung, Endothelial, Kidney, Pituitary, Bone, Testes, Smooth muscle, Spinal cord, Thyroid, Monocytes, Liver

Animal Models for Intracranial Aneurysm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intracranial Aneurysm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.6ELN, LOX, COL3A1, FBN2, PKD2, PKD1
2MP:000536910.5LOX, COL1A2, COL3A1, FBN2, PKD1, NOS3
3MP:000287310.5SOX17, PKD2, PKD1, NOS3, ENG, ELANE
4MP:000538510.4LOX, COL1A2, COL3A1, FBN2, PKD2, PKD1
5MP:001076810.2FBN2, SOX17, COL3A1, COL1A2, LOX, PKD2

Publications for Intracranial Aneurysm

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50PubMed
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Articles related to Intracranial Aneurysm:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Extracorporeal membrane oxygenation for acute life-threatening neurogenic pulmonary edema following rupture of an intracranial aneurysm. (23772167)
2013
2
Ischemia changes and tolerance ratio of evoked potential monitoring in intracranial aneurysm surgery. (22795547)
2013
3
Usefulness of monochromatic imaging with metal artifact reduction software for computed tomography angiography after intracranial aneurysm coil embolization. (24215905)
2013
4
An in vitro study of pulsatile fluid dynamics in intracranial aneurysm models treated with embolic coils and flow diverters. (23192467)
2013
5
Intracranial aneurysms in autosomal dominant polycystic kidney disease. (23449651)
2013
6
Sensitivity of Quantified Intracranial Aneurysm Geometry to Imaging Modality. (24151529)
2013
7
De novo large fusiform posterior circulation intracranial aneurysm presenting with subarachnoid hemorrhage 7 years after therapeutic internal carotid artery occlusion: case report and review of the literature. (22710380)
2012
8
Images in vascular medicine. A ruptured intracranial aneurysm with underlying cervicocranial fibromuscular dysplasia. (22006367)
2012
9
Spontaneous regression of an intracranial aneurysm after carotid endarterectomy. (22754731)
2012
10
Osteogenesis imperfecta, multiple intra-abdominal arterial dissections and a ruptured dissecting-type intracranial aneurysm. (22005702)
2011
11
Time-resolved 3D contrast-enhanced MRA on 3.0T: a non-invasive follow-up technique after stent-assisted coil embolization of the intracranial aneurysm. (22043147)
2011
12
Measurement of cortical microcirculation during intracranial aneurysm surgery by combined laser-Doppler flowmetry and photospectrometry. (21430590)
2011
13
Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-I_B, hypoxia-inducible factor-1A, and ETS transcription factors. (21336216)
2011
14
Uneventful delivery with caesarean section in a woman with a history of endovascular management of an intracranial aneurysm. (21973148)
2011
15
Association of intracranial aneurysm and Loeys-Dietz syndrome: case illustration, management, and literature review. (21792144)
2011
16
Emergency surgical salvage for severe intracranial aneurysm rupture during endovascular coiling procedures not amenable to additional coiling. (21748039)
2011
17
Intracranial stents being modeled as a porous medium: flow simulation in stented cerebral aneurysms. (21042856)
2011
18
Hemodynamic relationship between intracranial aneurysm and carotid stenosis: review of clinical cases and numerical analyses. (20444325)
2010
19
The genetics of sporadic ruptured and unruptured intracranial aneurysms: a genetic meta-analysis of 8 genes and 13 polymorphisms in approximately 20,000 individuals. (19780647)
2010
20
An intracranial aneurysm and dural arteriovenous fistula in a newborn. (21540622)
2010
21
Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. (20395613)
2010
22
The effects of aortic coarctation on cerebral hemodynamics and its importance in the etiopathogenesis of intracranial aneurysms. (22518256)
2010
23
Acute cerebral ischemia owing to unruptured dissecting intracranial aneurysm: an uncommon contraindication for intravenous thrombolysis. (20558402)
2010
24
Genome screen in familial intracranial aneurysm. (19144135)
2009
25
Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm. (19299629)
2009
26
Ruptured intracranial aneurysm in pregnancy: a case report. (21686812)
2009
27
Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental study. (19349824)
2009
28
Large-cohort comparison between three-dimensional time-of-flight magnetic resonance and rotational digital subtraction angiographies in intracranial aneurysm detection. (19556531)
2009
29
Guidelines for the surgical treatment of unruptured intracranial aneurysms: the first annual J. Lawrence pool memorial research symposium--controversies in the management of cerebral aneurysms. (18300906)
2008
30
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. (18176561)
2008
31
Intracranial aneurysm perforation during endosaccular coiling: impact on clinical outcome, initial occlusion, and recanalization rates. (18981878)
2008
32
Spinal subdural hematoma following intracranial aneurysm surgery: four case reports. (17245010)
2007
33
Assessment of flow in perforating arteries during intracranial aneurysm surgery using intraoperative near-infrared indocyanine green videoangiography. (17876226)
2007
34
Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (17287949)
2007
35
The versican gene and the risk of intracranial aneurysms. (16917090)
2006
36
Heparin-induced transient prolongation of the QT interval during endovascular embolisation of intracranial aneurysm. (16678734)
2006
37
A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality. (16904993)
2006
38
Mild intraoperative hypothermia during surgery for intracranial aneurysm. (15647576)
2005
39
Rupture of a giant intracranial aneurysm while starting cardiopulmonary bypass for hypothermic circulatory arrest. (15226650)
2004
40
Intracranial aneurysm surgery and its future. (14996982)
2004
41
Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences. (15218274)
2004
42
Endoglin is not a major susceptibility gene for intracranial aneurysm among Japanese. (12775886)
2003
43
Hemostatic closure device after carotid puncture for stent and coil placement in an intracranial aneurysm: technical note. (12063228)
2002
44
Spontaneous intracranial hypotension mimicking aneurysmal subarachnoid hemorrhage. (11270540)
2001
45
Giant serpentine intracranial aneurysm: a case report. (11752991)
2001
46
Ruptured intracranial aneurysm associated with isolated aortic arch interruption. (11151693)
2000
47
Polymorphism of the endoglin gene in patients with intracranial saccular aneurysms. (10223461)
1999
48
Angiotensin I-converting enzyme gene polymorphism in intracranial saccular aneurysm individuals. (9785588)
1998
49
Giant intracranial aneurysm and fibromuscular dysplasia in an adolescent with alpha 1-antitrypsin deficiency. (8751640)
1996
50
Severe alpha 1-antitrypsin deficiency and intracranial aneurysms. (7909064)
1994

Genetic Variations for Intracranial Aneurysm

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Expression for genes affiliated with Intracranial Aneurysm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for genes affiliated with Intracranial Aneurysm

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51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Intracranial Aneurysm

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1desmosine4410.9ELN, ELANE, SERPINA1, LOX
2ascorbic acid44 2411.9LOX, NOS3, SERPINA1, ENG, ELN
3procollagen4410.9COL1A2
4estrogen4410.9LOX, COL1A2, NOS3, SERPINA1, ENG, ELANE
5trp-p-24410.9PKD2, PKD1
6isodesmosine4410.9ELANE, ELN
7diisopropylfluorophosphate4410.8SERPINA1, ELANE, ELN
8beta-aminopropionitrile4410.8LOX, ELN
9cysteine4410.8LOX, COL1A2, FBN2, SERPINA1, ENG, ELANE
10Collagenase1110.8COL1A2, COL3A1
11alpha-aminoadipic semialdehyde4410.8LOX, ELN
12serine4410.8COL1A2, PKD1, LIMK1, NOS3, SERPINA1, ENG
13nppa4410.8COL1A2, COL3A1
14ethylenediamine4410.8LOX, ELANE
15hydroxylysine4410.8ELN, LOX
16beta-lactam4410.8PKD1, ELANE
17bleomycin44 1111.8LOX, NOS3, ELN
18oxygen44 2411.8LOX, ACE2, SERPINA1, ENG, ELANE
19pentosidine4410.7ELN, LOX
20h2o24410.7LOX, NOS3, SERPINA1, ELANE, ELN
21vitamin d4410.7COL1A2, NOS3, ELANE, ELN
22onoo4410.7SERPINA1, NOS3
23tannins4410.7ELN, ELANE
24(4-aminophenyl)mercuric acetate4410.6ELANE
25sodium dodecylsulfate4410.6ELN, ELANE, NOS3
26nppb44 59 2812.5COL1A2, COL3A1
27d penicillamine4410.5LOX, ELN
28hocl4410.5ELANE, SERPINA1
29sodium nitroprusside4410.4ELN, ELANE, NOS3
30thermolysin4410.2ELN, ELANE

GO Terms for genes affiliated with Intracranial Aneurysm

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16Gene Ontology
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Cellular components related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:00213310.5PKD1, PKD2
2motile primary ciliumGO:03151210.5PKD1, PKD2
3extracellular regionGO:00557610.4LOX, COL1A2, COL3A1, FBN2, ACE2, SERPINA1
4extracellular spaceGO:00561510.2LOX, COL1A2, COL3A1, ACE2, SERPINA1, ENG

Biological processes related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.8ELN, LOX, COL1A2, COL3A1, FBN2, ELANE
2extracellular matrix disassemblyGO:02261710.8ELANE, ENG, COL3A1, COL1A2
3collagen fibril organizationGO:03019910.8LOX, COL1A2, COL3A1
4blood vessel developmentGO:00156810.8COL3A1, COL1A2, LOX
5metanephric ascending thin limb developmentGO:07221810.7PKD2, PKD1
6mesonephric tubule developmentGO:07216410.7PKD2, PKD1
7heart loopingGO:00194710.7ENG, PKD2, SOX17
8mesonephric duct developmentGO:07217710.7PKD2, PKD1
9wound healingGO:04206010.7ENG, COL3A1, LOX
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:03165910.7PKD1, PKD2
11collagen catabolic processGO:03057410.6COL1A2, COL3A1, ELANE
12placenta blood vessel developmentGO:06067410.6PKD1, PKD2
13detection of mechanical stimulusGO:05098210.5PKD2, PKD1
14transforming growth factor beta receptor signaling pathwayGO:00717910.5ENG, COL3A1, COL1A2
15cytoplasmic sequestering of transcription factorGO:04299410.5PKD1, PKD2
16regulation of cell proliferationGO:04212710.4PKD2, ACE2, ENG
17spinal cord developmentGO:02151010.2PKD1, PKD2

Molecular functions related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.5COL3A1, COL1A2
2extracellular matrix structural constituentGO:00520110.2ELN, FBN2, COL3A1, COL1A2

Products for genes affiliated with Intracranial Aneurysm

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Sources for Intracranial Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet