MCID: INT030
MIFTS: 57

Intracranial Aneurysm malady

Neuronal diseases, Cardiovascular diseases, Rare diseases categories
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Summaries for Intracranial Aneurysm

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Sources:
34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

MalaCards: Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm and polycystic kidney disease. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B antisense RNA 1), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Calcium channels. The compounds beta-aminopropionitrile and alpha-aminoadipic semialdehyde have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related mouse phenotypes are integument and respiratory system.

NINDS:44 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.

Wikipedia:65 An intracranial aneurysm (also called cerebral or brain aneurysm) is a cerebrovascular disorder in which... more...

Aliases & Classifications for Intracranial Aneurysm

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8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Cardiovascular diseases


Aliases & Descriptions:

intracranial aneurysm 8 10 45 62
brain aneurysm 8 44 45 34 62
intracranial aneurysm, nos 8


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Disease Ontology8 DOID:10941
MeSH35 D002532
SNOMED-CT58 128609009, 42994005
NCIt40 C34458

Related Diseases for Intracranial Aneurysm

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17GeneCards, 18GeneDecks
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Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm31.8ELANE, LOX, FBN2, ELN, PKD1, PKD2
2polycystic kidney disease30.8PKD2, PKD1
3cerebral aneurysms30.5ELANE, PKD1, ELN
4ehlers-danlos syndrome type iv30.3COL3A1, ELN
5ehlers-danlos syndrome30.3ELN, ELANE
6abdominal aortic aneurysm30.3ELANE, ELN
7polycystic liver disease30.1PKD2, PKD1
8osteogenesis imperfecta30.0COL1A2, COL3A1
9polycystic kidney disease, autosomal dominant30.0PKD1, PKD2
10connective tissue disease29.8COL1A2, COL3A1, PKD1, ELN, LOX, FBN2
11cerebritis10.7
12kidney disease10.5
13endotheliitis10.5
14hypertension10.4
15fibromuscular dysplasia10.4
16tuberous sclerosis10.3
17carotid stenosis10.3
18ischemia10.3
19moyamoya disease10.3
20carotid artery occlusion10.2
21alpha 1-antitrypsin deficiency10.2
22cervicitis10.2
23tuberous sclerosis complex10.2
24headache10.2
25thromboembolism10.2
26blindness10.2
27arteriovenous fistula10.1
28klippel-trenaunay syndrome10.1
29panhypopituitarism10.1
30carotid artery dissection10.1
31polyarteritis nodosa10.1
32cortical blindness10.1
33chronic mucocutaneous candidiasis10.1
34pulmonary edema10.1
35arteriovenous malformation10.1
36loeys-dietz syndrome10.1
37arachnoiditis10.1
38aortic aneurysm10.1
39candidiasis10.1
40cranial nerve palsy10.1
41meningitis10.1
42migraine10.1
43aortic coarctation10.1
44intracranial aneurysms multiple congenital anomaly10.1
45progressive hemifacial atrophy10.1
46head injury10.1
47hypoxia10.1
48occipital horn syndrome10.1LOX
49emphysema due to aat deficiency10.1ELANE
50supravalvular aortic stenosis10.1ELN, LIMK1

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to intracranial aneurysm

Symptoms for Intracranial Aneurysm

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Drugs & Therapeutics for Intracranial Aneurysm

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Intracranial Aneurysm

Search NIH Clinical Center for Intracranial Aneurysm

Genetic Tests for Intracranial Aneurysm

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Anatomical Context for Intracranial Aneurysm

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33MalaCards
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MalaCards organs/tissues related to Intracranial Aneurysm:

33
Brain, Heart, Lung, Eye, Kidney, Endothelial, Pituitary, Testes, Bone, Smooth muscle, Thyroid, Monocytes, Spinal cord, Liver

Animal Models for Intracranial Aneurysm or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Intracranial Aneurysm:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0PKD1, COL3A1, COL1A2, ENG, LOX
2MP:00053887.6LOX, ENG, COL3A1, PKD2, PKD1, ELN
3MP:00053767.5LOX, ENG, COL3A1, PKD2, PKD1, ELN
4MP:00028737.4ELANE, PKD2, COL1A2, ENG, PKD1
5MP:00053787.3ENG, COL3A1, PKD2, FBN2, PKD1, COL1A2
6MP:00053697.2ENG, COL1A2, COL3A1, ELN, LOX, FBN2
7MP:00053856.8ELN, LOX, FBN2, PKD2, PKD1, COL3A1
8MP:00107686.1PKD2, COL3A1, COL1A2, PKD1, ELN, ELANE

Publications for Intracranial Aneurysm

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52PubMed
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Articles related to Intracranial Aneurysm:

(show top 50)    (show all 632)
idTitleAuthorsYear
1
Association between NFKB1 -94 insertion/deletion ATTG polymorphism and risk of intracranial aneurysm. (23675986)
2013
2
Propose a wall shear stress divergence to estimate the risks of intracranial aneurysm rupture. (24191140)
2013
3
Oxidative stress is associated with cell death, wall degradation, and increased risk of rupture of the intracranial aneurysm wall. (23096423)
2013
4
Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture. (23463757)
2013
5
Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment. (23381018)
2013
6
Extracorporeal membrane oxygenation for acute life-threatening neurogenic pulmonary edema following rupture of an intracranial aneurysm. (23772167)
2013
7
Benefits of 3D rotational DSA compared with 2D DSA in the evaluation of intracranial aneurysm. (22578227)
2012
8
De novo intracranial aneurysm formation following endovascular treatment of giant aneurysm in an infant: case report. (22167265)
2012
9
De novo large fusiform posterior circulation intracranial aneurysm presenting with subarachnoid hemorrhage 7 years after therapeutic internal carotid artery occlusion: case report and review of the literature. (22710380)
2012
10
Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm. (23065210)
2012
11
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. (22286173)
2012
12
Images in vascular medicine. A ruptured intracranial aneurysm with underlying cervicocranial fibromuscular dysplasia. (22006367)
2012
13
Persistent neurological deficit from iodinated contrast encephalopathy following intracranial aneurysm coiling. A case report and review of the literature. (22440599)
2012
14
Increased relative risk of lung cancer in 2,904 patients with saccular intracranial aneurysm disease in eastern Finland. (22343186)
2012
15
Osteogenesis imperfecta, multiple intra-abdominal arterial dissections and a ruptured dissecting-type intracranial aneurysm. (22005702)
2011
16
The rationale and design of the Giant Intracranial Aneurysm Registry: a retrospective and prospective study. (21557815)
2011
17
Time-resolved 3D contrast-enhanced MRA on 3.0T: a non-invasive follow-up technique after stent-assisted coil embolization of the intracranial aneurysm. (22043147)
2011
18
Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. (20706138)
2011
19
Identification of an autosomal dominant locus for intracranial aneurysm through a model-based family collection in a geographically limited area. (21451530)
2011
20
Frequency of intracranial aneurysms in patients with spontaneous intracranial hypotension. (21395391)
2011
21
Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. (20418302)
2010
22
Complete heart block complicating intracranial aneurysm surgery in a pregnant patient. (20228491)
2010
23
Peripheral intracranial aneurysm causing subdural hematoma without subarachnoid hemorrhage. (20083805)
2010
24
Automated intracranial aneurysm isolation and quantification. (21095707)
2010
25
Endovascular treatment of intracranial aneurysms associated with moyamoya disease or moyamoya syndrome. (20977854)
2010
26
Multiplicative impact of smoking and genetic predisposition on intracranial aneurysm formation. (20644401)
2010
27
Hemodynamic relationship between intracranial aneurysm and carotid stenosis: review of clinical cases and numerical analyses. (20444325)
2010
28
Association of meningioma and intracranial aneurysm: report of five cases and review of literature. (20139508)
2009
29
The role of collagen type I alpha2 polymorphisms: intracranial aneurysms in Koreans. (19559927)
2009
30
Combined endovascular and microsurgical procedures as complementary approaches in the treatment of a single intracranial aneurysm. (19096540)
2008
31
Rupture of intracranial aneurysm after partial clipping due to aspiration drainage system--a case report. (18637618)
2008
32
The interleukin-6 gene -572G>C promoter polymorphism is related to intracranial aneurysms in Chinese Han nationality. (18487018)
2008
33
The role of intraoperative micro-Doppler ultrasound in verifying proper clip placement in intracranial aneurysm surgery. (17981038)
2008
34
Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. (18323491)
2008
35
Association of kallikrein gene polymorphisms with intracranial aneurysms. (17761919)
2007
36
Increased apoptosis and cysteinyl aspartate specific protease-3 gene expression in human intracranial aneurysm. (17430778)
2007
37
The versican gene and the risk of intracranial aneurysms. (16917090)
2006
38
Intracranial aneurysm and carotid artery stenosis. (16866048)
2006
39
Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm. (16574921)
2006
40
Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13. (15540160)
2005
41
BehAset's disease, associated with subarachnoidal heamorrhage due to intracranial aneurysm. (15806330)
2005
42
Correlation between APOA gene polymorphism and intracranial aneurysm]. (15782489)
2005
43
Spontaneous regression of a primary cerebral tumor following vasospasm caused by subarachnoid hemorrhage due to rupture of an intracranial aneurysm--case report. (15185757)
2004
44
Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families. (15273433)
2004
45
Acute vasogenic edema induced by thrombosis of a giant intracranial aneurysm: a cause of pseudostroke after therapeutic occlusion of the parent vessel. (12812962)
2003
46
Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. (12750963)
2003
47
The influence of hemodynamic stress factors on intracranial aneurysm formation. (11702865)
2001
48
Intracranial aneurysms in Ehlers-Danlos syndrome type IV in early childhood. (11704406)
2001
49
Alkaptonuric ochronosis and multiple intracranial aneurysms. (2315833)
1990
50
Large intracranial aneurysm producing panhypopituitarism and frontal lobe syndrome. (13378585)
1956

Variations for Intracranial Aneurysm

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Expression for genes affiliated with Intracranial Aneurysm

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for genes affiliated with Intracranial Aneurysm

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Sources:
50PathCards, 60Thomson Reuters, 12EMD Millipore, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 53QIAGEN, 30KEGG
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Pathways related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ELN, ELANE
29.5PKD2, PKD1
39.3COL3A1, COL1A2
49.3COL1A2, COL3A1
59.3COL3A1, COL1A2
6
Show member pathways
9.3COL1A2, COL3A1
7
Show member pathways
9.2ELN, LOX, FBN2
8
Show member pathways
9.0COL1A2, COL3A1, LOX
9
Show member pathways
8.9COL1A2, COL3A1, ELN
108.9ELN, COL3A1, COL1A2
11
Show member pathways
8.3COL1A2, COL3A1, ELN, FBN2
12
Show member pathways
8.3FBN2, ELN, COL3A1, COL1A2
13
Show member pathways
8.0FBN2, LIMK1, ELN, COL3A1, COL1A2
14
Show member pathways
7.5COL1A2, FBN2, LOX, ELANE, ELN, COL3A1

Compounds for genes affiliated with Intracranial Aneurysm

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 24HMDB, 3BitterDB, 51PharmGKB
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Compounds related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1beta-aminopropionitrile4510.2LOX, ELN
2alpha-aminoadipic semialdehyde4510.2ELN, LOX
3hydroxylysine4510.1ELN, LOX
4pentosidine4510.1ELN, LOX
5d penicillamine4510.1ELN, LOX
6pyridinoline4510.1ELN, LOX
7deoxypyridinoline4510.0ELN, LOX
8ethylenediamine4510.0LOX, ELANE
9isodesmosine4510.0ELN, ELANE
10tannins459.9ELANE, ELN
11(4-aminophenyl)mercuric acetate459.9ELN, ELANE
12trp-p-2459.9PKD2, PKD1
13thermolysin459.9ELANE, ELN
14beta-lactam459.8ELANE, PKD1
15diisopropylfluorophosphate459.8ELN, ELANE
16nppa459.7COL3A1, COL1A2
17desmosine459.7ELN, ELANE, LOX
18alginate459.6ELN, ELANE
19nppb29 45 6111.6COL1A2, COL3A1
20carbon459.6LOX, ELANE, ELN
21dermatan sulfate459.6ELN, ELANE
22doxycycline45 1110.6ELN, ELANE
23ascorbic acid45 2410.6LOX, ELN, ENG
24cyanogen bromide459.6ELN, COL1A2
25valine459.6ELN, ELANE, LOX
26hyaluronic acid45 2410.5ENG, ELN, ELANE
27hydroxyproline45 24 1111.5ELN, LOX
28paraffin459.3LOX, ELN, ENG
29procollagen459.0LOX, ELN, COL3A1, COL1A2
30chloramphenicol45 3 51 1112.0ELANE, ELN, COL1A2
31glutamate458.9COL3A1, PKD1, ELN, ELANE
32vitamin d458.9ELANE, ELN, COL1A2
33estrogen458.4LOX, ELANE, ELN, COL1A2, ENG
34tyrosine458.2LIMK1, LOX, PKD1, COL1A2, ENG
35serine457.9LIMK1, ELANE, ELN, PKD1, COL1A2, ENG
36cysteine457.8FBN2, LOX, ELANE, ELN, COL1A2, ENG

GO Terms for genes affiliated with Intracranial Aneurysm

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16Gene Ontology
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Cellular components related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polycystin complexGO:0021339.5PKD2, PKD1
2motile primary ciliumGO:0315129.2PKD2, PKD1
3extracellular spaceGO:0056158.6ENG, COL1A2, COL3A1, LOX
4extracellular regionGO:0055767.4FBN2, LOX, ELANE, ELN, COL3A1, COL1A2

Biological processes related to Intracranial Aneurysm according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1metanephric ascending thin limb developmentGO:0722189.8PKD1, PKD2
2mesonephric tubule developmentGO:0721649.8PKD2, PKD1
3mesonephric duct developmentGO:0721779.8PKD2, PKD1
4positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycGO:0316599.8PKD2, PKD1
5placenta blood vessel developmentGO:0606749.8PKD2, PKD1
6detection of mechanical stimulusGO:0509829.8PKD1, PKD2
7digestive tract developmentGO:0485659.8PKD1, COL3A1
8cytoplasmic sequestering of transcription factorGO:0429949.8PKD2, PKD1
9wound healingGO:0420609.7ENG, LOX, COL3A1
10spinal cord developmentGO:0215109.7PKD2, PKD1
11neural tube developmentGO:0219159.7PKD2, PKD1
12skin developmentGO:0435889.7COL3A1, PKD1
13embryonic placenta developmentGO:0018929.7PKD1, PKD2
14JAK-STAT cascadeGO:0072599.6PKD2, PKD1
15calcium ion transmembrane transportGO:0705889.5PKD2, PKD1
16heart developmentGO:0075079.4PKD1, COL3A1, PKD2
17collagen fibril organizationGO:0301999.3LOX, COL3A1, COL1A2
18blood vessel developmentGO:0015689.3COL1A2, COL3A1, LOX
19heart loopingGO:0019479.3PKD2, ENG
20cellular response to amino acid stimulusGO:0712309.3COL3A1, COL1A2
21Rho protein signal transductionGO:0072669.3COL1A2, LIMK1
22transforming growth factor beta receptor signaling pathwayGO:0071799.2COL1A2, COL3A1, ENG
23collagen catabolic processGO:0305749.1COL1A2, COL3A1, ELANE
24extracellular matrix organizationGO:0301987.8COL1A2, COL3A1, ELN, ELANE, LOX, FBN2
25extracellular matrix disassemblyGO:0226177.7COL1A2, COL3A1, ELN, ELANE, ENG, FBN2

Molecular functions related to Intracranial Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD bindingGO:0463329.3COL1A2, COL3A1
2platelet-derived growth factor bindingGO:0484079.0COL1A2, COL3A1
3extracellular matrix structural constituentGO:0052018.3COL1A2, COL3A1, ELN, FBN2
4protein bindingGO:0055156.3LIMK1, LOX, ELANE, ELN, PKD1, PKD2

Products for genes affiliated with Intracranial Aneurysm

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  • Antibodies
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Sources for Intracranial Aneurysm

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet