MCID: INT030
MIFTS: 53

Intracranial Aneurysm

Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intracranial Aneurysm

MalaCards integrated aliases for Intracranial Aneurysm:

Name: Intracranial Aneurysm 12 52 42 14 69
Brain Aneurysm 12 51 52 41 69
Cerebral Arterial Aneurysm 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10941
MeSH 42 D002532
NCIt 47 C34458
SNOMED-CT 64 128609009 42994005
UMLS 69 C0007766

Summaries for Intracranial Aneurysm

NINDS : 51 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  An aneurysm can press on a nerve or surrounding tissue, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are slightly more common in women than in men.  The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. For example, a small, unchanging aneurysm will generally produce no symptoms, whereas a larger aneurysm that is steadily growing may produce symptoms such as headache, numbness, loss of feeling in the face or problems with the eyes. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Intracranial Aneurysm, also known as brain aneurysm, is related to intracranial aneurysms multiple congenital anomaly and fibromuscular dysplasia, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Acetazolamide and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

MedlinePlus : 41 a brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. they are sometimes called berry aneurysms because they are often the size of a small berry. most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. if a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. these can include a droopy eyelid double vision or other changes in vision pain above or behind the eye a dilated pupil numbness or weakness on one side of the face or body treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. if a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. any of these symptoms requires immediate medical attention. nih: national heart, lung, and blood institute

Wikipedia : 72 Intracranial aneurysm, also known as brain aneurysm, is a cerebrovascular disorder in which weakness in... more...

Related Diseases for Intracranial Aneurysm

Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
id Related Disease Score Top Affiliating Genes
1 intracranial aneurysms multiple congenital anomaly 11.9
2 fibromuscular dysplasia 11.3
3 autosomal dominant polycystic kidney disease 11.2
4 polycystic kidney disease 1 11.0
5 aneurysm 10.9
6 aneurysm, intracranial berry, 4 10.9
7 aneurysm, intracranial berry, 1 10.9
8 aneurysm, intracranial berry, 11 10.9
9 aneurysm, intracranial berry, 5 10.9
10 aneurysm, intracranial berry, 10 10.9
11 aneurysm, intracranial berry, 3 10.9
12 aneurysm, intracranial berry, 6 10.9
13 intracranial berry aneurysm 10.9
14 aneurysm, intracranial berry, 7 10.9
15 loeys-dietz syndrome 4 10.9
16 immunodeficiency 31c, autosomal dominant 10.9
17 aneurysm, intracranial berry, 9 10.9
18 aneurysm, intracranial berry, 8 10.9
19 beckwith-wiedemann syndrome due to 11p15 microdeletion 10.7 COL3A1 ENG
20 familial or sporadic hemiplegic migraine 10.6 COL3A1 ELN
21 chronic orthostatic intolerance 10.6 ELN PKD1
22 ehlers-danlos syndrome, classic type 10.6 COL3A1 ELN
23 deafness, autosomal recessive 91 10.6 COL1A2 COL3A1
24 lipoic acid biosynthesis defects 10.5 COL1A2 COL3A1
25 thrombocytopenia with or without dyserythropoietic anemia 10.4 COL3A1 FBN2
26 chronic fatigue syndrome 10.4 COL1A2 COL3A1 ELN
27 cutis laxa, autosomal dominant 10.3 ELN LIMK1
28 muscle hypertrophy 10.3 COL1A2 COL3A1
29 atrial fibrillation and stroke 10.2 CDKN2B-AS1 ELN LOX
30 cerebritis 10.2
31 olecranon bursitis 10.2 ELN LOX
32 tinea profunda 10.2 ELN MMP2
33 amyotrophic lateral sclerosis 12 10.2 CDKN2B CDKN2B-AS1 ELN
34 kidney disease 10.1
35 polycystic kidney disease 10.1
36 separation anxiety disorder 10.1 CDKN2B CDKN2B-AS1 ELN
37 bleeding disorder, platelet-type, 21 10.0 COL3A1 ELN MMP2
38 endotheliitis 10.0
39 vaginal spindle cell epithelioma 10.0 COL1A2 COL3A1 ELN FBN2
40 charcot-marie-tooth disease, axonal, type 2cc 10.0 ELN MMP2
41 thrombosis 10.0
42 carotid stenosis 9.9
43 arteriovenous malformation 9.8
44 moyamoya disease 9.8
45 cerebral aneurysms 9.8
46 ischemia 9.8
47 tuberous sclerosis 9.8
48 spinal cord intramedullary teratoma 9.8 ELN LOX MMP2
49 unverricht-lundborg syndrome 9.8 CDKN2B-AS1 THSD1
50 cervicitis 9.8

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to Intracranial Aneurysm

Symptoms & Phenotypes for Intracranial Aneurysm

UMLS symptoms related to Intracranial Aneurysm:


angina pectoris, back pain, chest pain, edema, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Intracranial Aneurysm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 FBN2 LOX MMP2 PKD1 SOX17 VCAN
2 homeostasis/metabolism MP:0005376 10.06 ACE2 CDKN2B COL1A2 COL3A1 ENG LOX
3 growth/size/body region MP:0005378 10.02 COL1A2 COL3A1 ENG FBN2 MMP2 PKD1
4 mortality/aging MP:0010768 9.9 ENG FBN2 LOX MMP2 PKD1 SOX17
5 integument MP:0010771 9.8 ACE2 CDKN2B COL1A2 COL3A1 ENG LOX
6 muscle MP:0005369 9.61 ACE2 COL1A2 COL3A1 ENG FBN2 LOX
7 respiratory system MP:0005388 9.17 ACE2 COL3A1 ENG FBN2 LOX MMP2

Drugs & Therapeutics for Intracranial Aneurysm

Drugs for Intracranial Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 173)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 2078-54-8 4943
3
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
4
Benzocaine Approved Phase 4,Phase 1,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
5
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
6
Desflurane Approved Phase 4 57041-67-5 42113
7
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-78-2 2244
9 Piracetam Approved Phase 4 7491-74-9
10
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
11 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Early Phase 1
12
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
13 Etiracetam Investigational Phase 4 33996-58-6
14 Anticonvulsants Phase 4
15 Carbonic Anhydrase Inhibitors Phase 4
16 diuretics Phase 4
17 Natriuretic Agents Phase 4
18 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
19 Anesthetics, General Phase 4,Phase 3,Phase 2
20 Anesthetics, Inhalation Phase 4,Phase 3,Phase 2
21 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
22 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
23 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
24 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
25 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
26 Neuroprotective Agents Phase 4,Phase 2,Phase 3
27 Nootropic Agents Phase 4,Phase 2,Phase 3
28 Protective Agents Phase 4,Phase 2,Phase 3
29 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2
31 Hypnotics and Sedatives Phase 4,Phase 3,Phase 1,Phase 2
32 Adrenergic Agents Phase 4,Phase 3,Phase 1,Phase 2
33 Adrenergic Agonists Phase 4,Phase 3,Phase 1,Phase 2
34 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 1,Phase 2
35 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 1,Phase 2
36 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
37 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
38 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1
39 Antipyretics Phase 4,Phase 3,Phase 1
40 Antirheumatic Agents Phase 4,Phase 3,Phase 1
41 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 1
42 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
43 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
44 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
45 Hematinics Phase 4,Phase 1
46 Epoetin alfa Phase 4 113427-24-0
47
Simvastatin Approved Phase 3 79902-63-9 54454
48
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
49
Ticagrelor Approved Phase 3 274693-27-5 9871419
50
Cholecalciferol Approved, Nutraceutical Phase 2, Phase 3 67-97-0 6221 10883523 5280795

Interventional clinical trials:

(show top 50) (show all 227)

id Name Status NCT ID Phase Drugs
1 Treatment of Cranial Internal Carotid Artery Aneurysm With Willis Covered Stent and Coil Embolization Unknown status NCT01029938 Phase 4
2 HYdrogel Coil Versus Bare Platinum Coil in Recanalization Imaging Data Study Unknown status NCT01516658 Phase 4
3 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
4 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
5 TRAIL: Treatment of Intracranial Aneurysms With LVIS® System Completed NCT02921711 Phase 4
6 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
7 The Registry to Study Safety and Performance of the CORDIS Vascular Reconstruction Device and Delivery System Completed NCT00486226 Phase 4
8 MAPS Trial: Matrix And Platinum Science Completed NCT00396981 Phase 4
9 PRET: Patients Prone to Recurrence After Endovascular Treatment Completed NCT00626912 Phase 4
10 A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
11 Aneurysm Wall Histology Registry Completed NCT01444664 Phase 4
12 Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery Completed NCT02987218 Phase 4 Propofol;Desflurane
13 TARGET Intracranial Aneurysm Coiling Registry Recruiting NCT01748903 Phase 4
14 Stenting in the Treatment of Aneurysm Trial Recruiting NCT01340612 Phase 4
15 Flow Diversion in Intracranial Aneurysm Treatment Recruiting NCT01349582 Phase 4
16 Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil Recruiting NCT02729740 Phase 4
17 Seizure Prophylaxis in Aneurysm Repair Recruiting NCT01801072 Phase 4 Levetiracetam
18 LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy Recruiting NCT01762137 Phase 4
19 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Recruiting NCT02478346 Phase 4 Fluorescein Sodium
20 Study of the Penumbra Coil 400 System to Treat Aneurysm Active, not recruiting NCT01465841 Phase 4
21 Study of Antiplatelet Therapy for Intracranial Aneurysm Stent-assisted Coiling Not yet recruiting NCT02224131 Phase 4 Aspirin and clopidogrel;Aspirin and clopidogrel
22 HydroCoil Cerebral Aneurysm Treatment Trial Terminated NCT01195129 Phase 4
23 Seizure Prophylaxis in Aneurysm Repair Terminated NCT01974700 Phase 4 Levetiracetam
24 Treating Patients With Aneurysmal SubArachnoid Hemorrhage (SAH) With Epoetin Alfa Terminated NCT00626574 Phase 4 Epoetin alfa;Saline
25 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Terminated NCT02028325 Phase 4 Fluorescein Sodium
26 Hydrogel Balloon Assisted Intracranial Aneurysm Coiling Registry Withdrawn NCT02037932 Phase 4
27 Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01787123 Phase 2, Phase 3 Intravenous Cerebrolysin
28 Feasibility Study of the LVIS™ (Low-profile Visualized Intraluminal Support)Device Completed NCT01541254 Phase 2, Phase 3
29 Complete Occlusion of Coilable Aneurysms Completed NCT00777907 Phase 3
30 Pivotal Study of the LVIS (Low Profile Visualized Intraluminal Support) Completed NCT01793792 Phase 3
31 Hypothermia During Intracranial Aneurysm Surgery Trial Completed NCT00029133 Phase 3
32 Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial Completed NCT00731627 Phase 3 placebo;simvastatin
33 Esmolol Infusion in Patients Undergoing Craniotomy Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
34 Framing Eighteen Coils in Cerebral Aneurysms Trial Recruiting NCT01655784 Phase 3
35 Ticagrelor vs Clopidogrel for Platelet Inhibition in Stenting for Cerebral Aneurysm Recruiting NCT02675205 Phase 3 Clopidogrel;Ticagrelor;aspirin
36 Acetylsalicylic Acid Plus Intensive Blood Pressure Treatment in Patients With Unruptured Intracranial Aneurysms Recruiting NCT03063541 Phase 3 Acetylsalicylic acid
37 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3 Esmolol;Dexmedetomidine
38 Hypovitaminosis D in Neurocritical Patients Recruiting NCT02881957 Phase 2, Phase 3 Cholecalciferol
39 The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms Active, not recruiting NCT01636453 Phase 3
40 Pivotal Study of the FRED Stent System in the Treatment of Intracranial Aneurysms Active, not recruiting NCT01801007 Phase 3
41 Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage. Not yet recruiting NCT03187405 Phase 3 EVD + IVF with Alteplase
42 Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Unknown status NCT02011321 Phase 2 clevidipine
43 Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
44 Safety and Pharmacokinetic Evaluation of Nitrite for Prevention of Cerebral Vasospasm Completed NCT00873015 Phase 2 Sodium nitrite;Saline
45 Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage Completed NCT01893190 Phase 1, Phase 2 Nimodipine;Nimodipine Microparticles
46 Dexmedetomidine and Subarachnoid Haemorrhage Completed NCT01664520 Phase 1, Phase 2 Dexmedetomidine infusion
47 Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Recruiting NCT01895881 Phase 2 Estradiol;Placebo
48 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose Intravenous Unfractionated Heparin Infusion (14 days)
49 Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage: Recruiting NCT02432157 Phase 1, Phase 2 HTS 3%;Standard fluid management
50 Sevoflurane in Subarachnoidal Haemorrhage Recruiting NCT02946437 Phase 2 Sevoflurane;Propofol;Midazolam

Search NIH Clinical Center for Intracranial Aneurysm

Cochrane evidence based reviews: intracranial aneurysm

Genetic Tests for Intracranial Aneurysm

Anatomical Context for Intracranial Aneurysm

MalaCards organs/tissues related to Intracranial Aneurysm:

39
Brain, Eye, Heart, Lung, Kidney, Pituitary, Endothelial

Publications for Intracranial Aneurysm

Articles related to Intracranial Aneurysm:

(show top 50) (show all 797)
id Title Authors Year
1
Diagnostic value of 3D time-of-flight magnetic resonance angiography for detecting intracranial aneurysm: a meta-analysis. ( 28887618 )
2017
2
Small versus Large Ruptured Intracranial Aneurysm: Concerns with the Site of Aneurysm. ( 28088803 )
2017
3
Prevalence of Intracranial Aneurysm in Women With Fibromuscular Dysplasia: A Report From the US Registry for Fibromuscular Dysplasia. ( 28715558 )
2017
4
MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture. ( 28214880 )
2017
5
Initial Clinical Experience with AView-A Clinical Computational Platform for Intracranial Aneurysm Morphology, Hemodynamics, and Treatment Management. ( 28919570 )
2017
6
Magnetic Resonance Imaging Susceptibility-Weighted Imaging Lesion and Contrast Enhancement May Represent Infectious Intracranial Aneurysm in Infective Endocarditis. ( 28848178 )
2017
7
Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation. ( 28754830 )
2017
8
Aspirin for the Prevention of Intracranial Aneurysm Rupture. ( 28899056 )
2017
9
Cavernous angioma presenting with subarachnoid hemorrhage which was diffusely distributed in the basal cisterns and mimicked intracranial aneurysm rupture. ( 28904829 )
2017
10
Novel ELN mutation in a family with supravalvular aortic stenosis and intracranial aneurysm. ( 27866049 )
2017
11
Relationship between intracranial aneurysms and the severity of autosomal dominant polycystic kidney disease. ( 28884237 )
2017
12
Cervical artery tortuosity is associated with intracranial aneurysm. ( 28073311 )
2017
13
Anxiety, depression and quality of life in patients with a treated or untreated unruptured intracranial aneurysm. ( 28778800 )
2017
14
Pipeline embolization device for the treatment of a traumatic intracranial aneurysm in a child. ( 28064352 )
2017
15
Treatment of Moyamoya Disease and Unruptured Intracranial Aneurysm in Floating-Harbor Syndrome. ( 28549641 )
2017
16
Differences in Morphologic and Hemodynamic Characteristics for "PHASES-Based" Intracranial Aneurysm Locations. ( 28912279 )
2017
17
Anesthetic management in a patient of autosomal dominant polycystic kidney disease with end stage renal disease undergoing endovascular coiling for multiple intracranial aneurysms. ( 28781456 )
2017
18
Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease. ( 28843770 )
2017
19
Passive smoking is not associated with risk of intracranial aneurysm rupture in nonsmoking women. ( 28765026 )
2017
20
A 55-Year-Old Male Presenting with Altered Mental Status - A Complicated Case of Intracranial Aneurysm. ( 28881419 )
2017
21
Methodology for Computational Fluid Dynamic Validation for Medical Use: Application to Intracranial Aneurysm. ( 28857116 )
2017
22
Unruptured intracranial aneurysm and first episode psychosis: The mystery was finally solved. ( 28953760 )
2017
23
Association of intracranial aneurysm rupture with smoking duration, intensity, and cessation. ( 28855408 )
2017
24
A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans. ( 28792146 )
2017
25
Clinical and angiographic outcomes following endovascular treatment of very small (3a88mm or smaller) intracranial aneurysm: A single-center experience. ( 28906352 )
2017
26
Hyperhomocysteinemia as a Risk Factor for Saccular Intracranial Aneurysm: A Cohort Study in a Chinese Han Population. ( 28943219 )
2017
27
Primary Cilia Deficiency Induces Intracranial Aneurysm. ( 28800037 )
2017
28
Clinical outcomes after craniotomy for unruptured intracranial aneurysm in patients with coronary artery disease. ( 28887082 )
2017
29
Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. ( 28761511 )
2017
30
Impact of antithrombotic treatment on clinical outcomes after craniotomy for unruptured intracranial aneurysm. ( 28865323 )
2017
31
Characteristics and Outcomes of Patients with Anterior Circulation Intracranial Aneurysm Managed with Clipping in Hospital Sungai Buloh. ( 28090185 )
2016
32
Future prospects for the development of a novel medical therapy for intracranial aneurysm. ( 27478047 )
2016
33
Is Carotid Revascularization Safe for Patients with Concomitant Carotid Stenosis and Intracranial Aneurysms? ( 27250773 )
2016
34
Diabetes may affect intracranial aneurysm stabilization in older patients: Analysis based on intraoperative findings. ( 27313965 )
2016
35
Predicting Factors of Chronic Subdural Hematoma Following Surgical Clipping in Unruptured and Ruptured Intracranial Aneurysm. ( 27651863 )
2016
36
Aberrant Expression of microRNA-9 Contributes to Development of Intracranial Aneurysm by Suppressing Proliferation and Reducing Contractility of Smooth Muscle Cells. ( 27824808 )
2016
37
Growth and subsequent disappearance of a ruptured small saccular intracranial aneurysm: A morphometric and flow-dynamic analysis. ( 27470928 )
2016
38
Intracranial aneurysm and sildenafil. ( 27034561 )
2016
39
"Postoperative Delayed Paradoxical Depression (PDPD) after Uncomplicated Intracranial Aneurysm Surgery". ( 27913259 )
2016
40
Sex-dichotomous effects of NOS1AP promoter DNA methylation on intracranial aneurysm and brain arteriovenous malformation. ( 27080431 )
2016
41
Flow Diversion for Intracranial Aneurysm Management: A New Standard of Care. ( 27160270 )
2016
42
IMAGES IN CLINICAL MEDICINE. Giant Thrombosed Intracranial Aneurysm. ( 27557304 )
2016
43
Late recurrence of a completely occluded large intracranial aneurysm treated with a Tubridge flow diverter. ( 27342762 )
2016
44
Daughter sac formation related to blood inflow jet in an intracranial aneurysm: A case study. ( 27647032 )
2016
45
Forty-two-year-old female patient with resistant hypertension, bilateral renal fibromuscular dysplasia and intracranial aneurysm. ( 27980558 )
2016
46
THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. ( 27895300 )
2016
47
Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells. ( 27416931 )
2016
48
Spontaneous thrombosis of giant intracranial aneurysm and posterior cerebral artery followed by also spontaneous recanalization. ( 26958421 )
2016
49
Sudden-onset monocular blindness following orbito-zygomatic craniotomy for a ruptured intracranial aneurysm. ( 27797793 )
2016
50
Acute normovolemic hemodilution to avoid blood transfusion during intracranial aneurysm surgery in a patient with atypical antibodies. ( 26957709 )
2016

Variations for Intracranial Aneurysm

Copy number variations for Intracranial Aneurysm from CNVD:

7 (show top 50) (show all 60)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39938 10 12200000 22600000 Loss Intracranial aneurysm
2 47489 10 94100000 97000000 Amplification HHEX Intracranial aneurysm
3 57447 11 63400000 77100000 Amplification FADD Intracranial aneurysm
4 58058 11 65900000 70400000 Gain Intracranial aneurysm
5 58059 11 65900000 75200000 Gain Intracranial aneurysm
6 61265 11 97200000 110400000 Amplification BIRC2 Intracranial aneurysm
7 61266 11 97200000 110400000 Amplification BIRC3 Intracranial aneurysm
8 65029 12 14800000 26500000 Amplification SLC21A8 Intracranial aneurysm
9 67921 12 46400000 58100000 Amplification PFKM Intracranial aneurysm
10 67922 12 46400000 58100000 Amplification SENP1 Intracranial aneurysm
11 75163 13 17900000 115169878 Copy number Intracranial aneurysm
12 77541 13 45200000 59600000 Copy number Intracranial aneurysm
13 79537 13 73300000 79000000 Amplification Intracranial aneurysm
14 87453 14 73800000 79300000 Gain Intracranial aneurysm
15 119789 18 17200000 19000000 Amplification Intracranial aneurysm
16 122647 18 59000000 73100000 Loss Intracranial aneurysm
17 133739 19 6900000 14000000 Amplification RAD23A Intracranial aneurysm
18 135805 2 121010413 121052286 Amplification RALB Intracranial aneurysm
19 140407 2 197400000 209000000 Amplification ALS2 Intracranial aneurysm
20 140408 2 197400000 209000000 Amplification BMPR2 Intracranial aneurysm
21 140409 2 197400000 209000000 Amplification CYP20A1 Intracranial aneurysm
22 140410 2 197400000 209000000 Amplification NOP5 Intracranial aneurysm
23 140411 2 197400000 209000000 Amplification SUMO1 Intracranial aneurysm
24 140412 2 197400000 209000000 Amplification WDR12 Intracranial aneurysm
25 150455 20 1 5100000 Gain Intracranial aneurysm
26 152629 20 32100000 34400000 Gain Intracranial aneurysm
27 154535 20 46400000 49800000 Gain Intracranial aneurysm
28 155818 20 58400000 63025520 Gain Intracranial aneurysm
29 164525 22 37600000 51304566 Amplification PLXNB2 Intracranial aneurysm
30 168338 3 129200000 138700000 Amplification RAB6B Intracranial aneurysm
31 171398 3 167401694 167452651 Amplification PDCD10 Intracranial aneurysm
32 171571 3 169755735 169803181 Amplification Intracranial aneurysm
33 172483 3 182700000 187900000 Amplification LAMP3 Intracranial aneurysm
34 172484 3 182700000 187900000 Amplification MCCC1 Intracranial aneurysm
35 173254 3 192300000 198022430 Amplification TFRC Intracranial aneurysm
36 189115 4 70500000 76300000 Loss Intracranial aneurysm
37 191657 5 1 4500000 Gain Intracranial aneurysm
38 191840 5 10250281 10266501 Amplification CCT5 Intracranial aneurysm
39 194596 5 14143828 14509458 Amplification TRIO Intracranial aneurysm
40 199711 5 42500000 46100000 Gain Intracranial aneurysm
41 202898 5 892968 918164 Amplification TRIP13 Intracranial aneurysm
42 226168 7 55086724 55275031 Amplification EGFR Intracranial aneurysm
43 232751 8 119200000 127300000 Gain Intracranial aneurysm
44 234358 8 134048972 134115310 Amplification SLA Intracranial aneurysm
45 234391 8 134203281 134243932 Amplification WISP1 Intracranial aneurysm
46 234397 8 134249413 134309547 Amplification NDRG1 Intracranial aneurysm
47 239116 8 37701397 37707431 Amplification BRF2 Intracranial aneurysm
48 239184 8 37963348 37997228 Amplification ASH2L Intracranial aneurysm
49 239226 8 38132560 38239790 Amplification WHSC1L1 Intracranial aneurysm
50 239696 8 41119475 41166990 Amplification SFRP1 Intracranial aneurysm

Expression for Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for Intracranial Aneurysm

Pathways related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 CDKN2B COL1A2 COL3A1 ELN FBN2 LIMK1
2
Show member pathways
12.94 COL1A2 COL3A1 ELN FBN2 LIMK1 MMP2
3
Show member pathways
12.69 COL1A2 COL3A1 ELN FBN2 VCAN
4
Show member pathways
12.44 ACE2 COL1A2 COL3A1 ELN LOX
5
Show member pathways
11.82 COL1A2 COL3A1 ELN FBN2 LOX MMP2
6 11.54 COL1A2 COL3A1 MMP2
7
Show member pathways
11.2 ELN FBN2 LOX
8 11.06 COL1A2 MMP2
9 11.04 ACE2 MMP2
10 11.04 COL1A2 COL3A1 MMP2 VCAN
11 11.03 COL1A2 COL3A1
12 10.85 ENG FBN2
13 10.85 ACE2 MMP2

GO Terms for Intracranial Aneurysm

Cellular components related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 ACE2 COL1A2 COL3A1 ENG LOX MMP2
2 extracellular region GO:0005576 9.81 ACE2 COL1A2 COL3A1 ELN FBN2 LOX
3 collagen trimer GO:0005581 9.43 COL1A2 COL3A1 LOX
4 extracellular matrix GO:0031012 9.35 COL1A2 COL3A1 FBN2 MMP2 VCAN
5 proteinaceous extracellular matrix GO:0005578 9.17 COL1A2 COL3A1 ELN FBN2 LOX MMP2

Biological processes related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.67 COL3A1 ENG LOX PKD1
2 skeletal system development GO:0001501 9.65 COL1A2 COL3A1 VCAN
3 extracellular matrix disassembly GO:0022617 9.61 ELN FBN2 MMP2
4 collagen catabolic process GO:0030574 9.5 COL1A2 COL3A1 MMP2
5 digestive tract development GO:0048565 9.49 COL3A1 PKD1
6 renal system development GO:0072001 9.46 PKD1 SOX17
7 blood vessel development GO:0001568 9.43 COL1A2 COL3A1 PKD1
8 bone trabecula formation GO:0060346 9.4 FBN2 MMP2
9 cellular response to amino acid stimulus GO:0071230 9.33 COL1A2 COL3A1 MMP2
10 collagen fibril organization GO:0030199 9.13 COL1A2 COL3A1 LOX
11 extracellular matrix organization GO:0030198 9.1 COL1A2 COL3A1 ELN FBN2 LOX VCAN

Molecular functions related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan binding GO:0005539 9.16 ENG VCAN
2 extracellular matrix structural constituent GO:0005201 9.02 COL1A2 COL3A1 ELN FBN2 VCAN
3 platelet-derived growth factor binding GO:0048407 8.96 COL1A2 COL3A1
4 protein binding GO:0005515 10.07 ACE2 CDKN2B COL1A2 COL3A1 ELN ENG

Sources for Intracranial Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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