MCID: INT145
MIFTS: 36

Intracranial Hemorrhage in Brain Cerebrovascular Malformations malady

Neuronal diseases, Cardiovascular diseases, Fetal diseases categories

Summaries for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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46OMIM, 32MalaCards
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MalaCards: Intracranial Hemorrhage in Brain Cerebrovascular Malformations, also known as intracranial arteriovenous malformation, is related to arteriovenous malformation and cerebritis, and has symptoms including peripheral arteriovenous fistula, visceral angiomatosis (excluding skin) and cerebral vascular anomalies. An important gene associated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are PI3K-Akt signaling pathway and p70S6K Signaling. The compounds pha 665752 and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include brain and skin.

Description from OMIM:46 108010

Aliases & Classifications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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46OMIM, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Neuronal diseases, Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
intracranial arteriovenous malformation:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

intracranial hemorrhage in brain cerebrovascular malformations 46
intracranial arteriovenous malformation 48 60
cerebral arteriovenous malformation 48
cerebral arteriovenous fistula 48
cerebral arteriovenous shunt 48


External Ids:

SNOMED-CT via Orphanet57 234142008
OMIM46 108010
MESH via Orphanet35 D002538
ICD10 via Orphanet26 Q28.2
UMLS via Orphanet61 C0007772

Related Diseases for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:



Diseases related to intracranial hemorrhage in brain cerebrovascular malformations

Clinical Features for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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46OMIM, 48Orphanet
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Clinical features from OMIM:

108010

Clinical synopsis from OMIM:

108010

Symptoms:

48
  • peripheral arteriovenous fistula
  • visceral angiomatosis (excluding skin)
  • cerebral vascular anomalies

Drugs & Therapeutics for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Drug clinical trials:

Search ClinicalTrials for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search NIH Clinical Center for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search CenterWatch for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Genetic Tests for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Anatomical Context for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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32MalaCards
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MalaCards organs/tissues related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

32
Brain, Skin

Animal Models for Intracranial Hemorrhage in Brain Cerebrovascular Malformations or affiliated genes

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Publications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Genetic Variations for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Expression for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search GEO for disease gene expression data for Intracranial Hemorrhage in Brain Cerebrovascular Malformations.

Pathways for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources:
29KEGG, 51QIAGEN, 53Reactome
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Pathways related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1IL6, HGF
2
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9.1IL6, HGF
39.1HGF, IL6
4
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9.1IL6, HGF
5
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9.1IL6, HGF
6
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9.1IL6, HGF

Compounds for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources:
59Tocris Bioscience, 44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1pha 665752599.5IL6, HGF
2su 11274599.5IL6, HGF
3pf 04217903 mesylate599.5IL6, HGF
4rebamipide449.5HGF, IL6
5crizotinib49 5910.5HGF, IL6
6filgrastim44 1110.5IL6, HGF
7pmma449.5IL6, HGF
8dextran sulfate449.5HGF, IL6
9pdtc449.5IL6, HGF
10pge1449.5IL6, HGF
11thalidomide44 49 59 1112.5IL6, HGF
12sp 60012544 5910.4HGF, IL6
13prednisolone44 28 1111.4IL6, HGF
14tgf beta1449.4IL6, HGF
15herbimycin a44 5910.4HGF, IL6
16hyaluronic acid44 2410.4IL6, HGF
17methotrexate44 49 1111.4IL6, HGF
18n acetylcysteine449.4IL6, HGF
19indomethacin44 59 28 1112.4HGF, IL6
20sb 20358044 5910.3IL6, HGF
21vitamin d449.3IL6, HGF
22histamine44 28 2411.3HGF, IL6
23pd 98,059449.2IL6, HGF
24ly294002449.2IL6, HGF
25actinomycin d449.1HGF, IL6
26lactate449.1IL6, HGF
27genistein44 28 59 2 11 2414.0IL6, HGF
28pge2448.8IL6, HGF

GO Terms for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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16Gene Ontology
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Biological processes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:0456699.1IL6, HGF
2platelet activationGO:0301689.1IL6, HGF
3negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.0IL6, HGF
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8IL6, HGF

Molecular functions related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1IL6, HGF

Products for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet