MCID: INT145
MIFTS: 30

Intracranial Hemorrhage in Brain Cerebrovascular Malformations malady

Genetic diseases (common), Neuronal diseases categories

Summaries for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards based summary: Intracranial Hemorrhage in Brain Cerebrovascular Malformations, also known as intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to, is related to arteriovenous malformation and central nervous system vasculitis, and has symptoms including autosomal dominant inheritanceand cerebral arteriovenous malformation. An important gene associated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations is HGF (hepatocyte growth factor (hepapoietin A; scatter factor)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds pha 665752 and pf 04217903 mesylate have been mentioned in the context of this disorder. Affiliated tissues include brain.

Description from OMIM:47 108010

Aliases & Classifications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Intracranial Hemorrhage in Brain Cerebrovascular Malformations, Aliases & Descriptions:

Name: Intracranial Hemorrhage in Brain Cerebrovascular Malformations 47
Intracranial Hemorrhage in Brain Cerebrovascular Malformations, Susceptibility to 11
 
Arteriovenous Malformations of the Brain 47
Intracranial Arteriovenous Malformation 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


External Ids:

OMIM47 108010

Related Diseases for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1arteriovenous malformation10.2
2central nervous system vasculitis10.2
3vasculitis10.2
4inflammatory bowel disease 110.0IL6
5classic kaposi sarcoma10.0IL6
6arteriosclerosis10.0HGF
7diabetes mellitus, insulin-dependent10.0IL6
8endometriosis10.0HGF, IL6
9chronic kidney failure10.0HGF, IL6
10myeloma10.0HGF, IL6
11hepatocellular carcinoma10.0IL6, HGF
12primary hyperoxaluria10.0HGF, IL6

Graphical network of diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:



Diseases related to intracranial hemorrhage in brain cerebrovascular malformations

Symptoms for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Symptoms by clinical synopsis from OMIM:

108010

Clinical features from OMIM:

108010

HPO human phenotypes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 cerebral arteriovenous malformation HP:0002408

Drugs & Therapeutics for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Drug clinical trials:

Search ClinicalTrials for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search NIH Clinical Center for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Genetic Tests for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Anatomical Context for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards organs/tissues related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

33
Brain

Animal Models for Intracranial Hemorrhage in Brain Cerebrovascular Malformations or affiliated genes

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Publications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Variations for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Expression for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Search GEO for disease gene expression data for Intracranial Hemorrhage in Brain Cerebrovascular Malformations.

Pathways for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Pathways related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Compounds related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1pha 665752619.6HGF, IL6
2pf 04217903 mesylate619.6IL6, HGF
3su 11274619.6IL6, HGF
4rebamipide459.6HGF, IL6
5filgrastim45 1310.5IL6, HGF
6crizotinib61 5110.5IL6, HGF
7pmma459.5HGF, IL6
8dextran sulfate459.5IL6, HGF
9pdtc459.5HGF, IL6
10pge1459.5HGF, IL6
11aprotinin45 1310.5IL6, HGF
12thalidomide45 51 61 1312.5HGF, IL6
13sp 60012545 6110.5HGF, IL6
14prednisolone45 30 1311.5IL6, HGF
15hydrocortisone45 3 61 1312.5HGF, IL6
16tgf beta1459.5IL6, HGF
17herbimycin a45 6110.5HGF, IL6
18hyaluronic acid45 2610.5HGF, IL6
19methotrexate51 45 1311.5IL6, HGF
20n acetylcysteine459.5HGF, IL6
21indomethacin45 30 61 1312.5IL6, HGF
22sb 20358045 6110.5HGF, IL6
23vitamin d459.5HGF, IL6
24norepinephrine45 26 1311.5IL6, HGF
25histamine45 30 2611.4HGF, IL6
26pd 98,059459.4IL6, HGF
27ly294002459.4HGF, IL6
28actinomycin d459.4HGF, IL6
29genistein45 30 61 3 26 1314.4IL6, HGF
30cyclosporin a45 30 6111.4HGF, IL6
31pge2459.4IL6, HGF
32lactate459.4HGF, IL6
33thymidine45 2610.3HGF, IL6
34creatinine459.3IL6, HGF
35cycloheximide459.3HGF, IL6
36testosterone45 61 26 1312.2IL6, HGF
37dexamethasone45 51 30 1312.2HGF, IL6
38vegf459.1HGF, IL6
39retinoic acid45 2610.1HGF, IL6
40alanine459.0IL6, HGF
41estrogen458.8HGF, IL6

GO Terms for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Biological processes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:00456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:00459449.1HGF, IL6
5platelet activationGO:00301689.0IL6, HGF
6negative regulation of apoptotic processGO:00430668.8HGF, IL6

Molecular functions related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.1HGF, IL6

Products for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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