MCID: INT145
MIFTS: 37

Intracranial Hemorrhage in Brain Cerebrovascular Malformations malady

Neuronal diseases, Cardiovascular diseases, Fetal diseases, Rare diseases categories
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Summaries for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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47OMIM, 33MalaCards
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MalaCards: Intracranial Hemorrhage in Brain Cerebrovascular Malformations, also known as intracranial arteriovenous malformation, is related to intracranial arteriovenous malformation and arteriovenous malformation, and has symptoms including visceral angiomatosis (excluding skin), cerebral vascular anomalies and peripheral arteriovenous fistula. An important gene associated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations is HGF (hepatocyte growth factor (hepapoietin A; scatter factor)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds pha 665752 and pf 04217903 mesylate have been mentioned in the context of this disorder. Affiliated tissues include brain and skin.

Description from OMIM:47 108010

Aliases & Classifications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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49Orphanet, 62UMLS, 47OMIM, 59SNOMED-CT via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
intracranial arteriovenous malformation:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

intracranial hemorrhage in brain cerebrovascular malformations 47
intracranial arteriovenous malformation 49 62
cerebral arteriovenous malformation 49
cerebral arteriovenous fistula 49
cerebral arteriovenous shunt 49


External Ids:

SNOMED-CT via Orphanet59 234142008
OMIM47 108010
MESH via Orphanet36 D002538
ICD10 via Orphanet26 Q28.2
UMLS via Orphanet63 C0007772

Related Diseases for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:



Diseases related to intracranial hemorrhage in brain cerebrovascular malformations

Symptoms for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

108010

Clinical features from OMIM:

108010

Symptoms:

49
  • visceral angiomatosis (excluding skin)
  • cerebral vascular anomalies
  • peripheral arteriovenous fistula

Drugs & Therapeutics for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search NIH Clinical Center for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Genetic Tests for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Anatomical Context for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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33MalaCards
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MalaCards organs/tissues related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

33
Brain, Skin

Animal Models for Intracranial Hemorrhage in Brain Cerebrovascular Malformations or affiliated genes

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Publications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Variations for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Expression for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search GEO for disease gene expression data for Intracranial Hemorrhage in Brain Cerebrovascular Malformations.

Pathways for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 55Reactome
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Pathways related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources:
61Tocris Bioscience, 45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1pha 665752619.6HGF, IL6
2pf 04217903 mesylate619.6IL6, HGF
3su 11274619.6IL6, HGF
4rebamipide459.6HGF, IL6
5filgrastim45 1110.5IL6, HGF
6crizotinib61 5110.5IL6, HGF
7pmma459.5HGF, IL6
8dextran sulfate459.5IL6, HGF
9pdtc459.5HGF, IL6
10pge1459.5HGF, IL6
11aprotinin45 1110.5IL6, HGF
12thalidomide45 51 61 1112.5HGF, IL6
13sp 60012545 6110.5HGF, IL6
14prednisolone45 29 1111.5IL6, HGF
15hydrocortisone45 3 61 1112.5HGF, IL6
16tgf beta1459.5IL6, HGF
17herbimycin a45 6110.5HGF, IL6
18hyaluronic acid45 2410.5HGF, IL6
19methotrexate51 45 1111.5IL6, HGF
20n acetylcysteine459.5HGF, IL6
21indomethacin45 29 61 1112.5IL6, HGF
22sb 20358045 6110.5HGF, IL6
23vitamin d459.5HGF, IL6
24norepinephrine45 24 1111.5IL6, HGF
25histamine45 29 2411.4HGF, IL6
26pd 98,059459.4IL6, HGF
27ly294002459.4HGF, IL6
28actinomycin d459.4HGF, IL6
29genistein45 29 61 3 24 1114.4IL6, HGF
30cyclosporin a45 29 6111.4HGF, IL6
31pge2459.4IL6, HGF
32lactate459.4HGF, IL6
33thymidine45 2410.3HGF, IL6
34creatinine459.3IL6, HGF
35cycloheximide459.3HGF, IL6
36testosterone45 61 24 1112.2IL6, HGF
37dexamethasone45 51 29 1112.2HGF, IL6
38vegf459.1HGF, IL6
39retinoic acid45 2410.1HGF, IL6
40alanine459.0IL6, HGF
41estrogen458.8HGF, IL6

GO Terms for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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16Gene Ontology
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Biological processes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:0456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:0459449.1HGF, IL6
5platelet activationGO:0301689.0IL6, HGF
6negative regulation of apoptotic processGO:0430668.8HGF, IL6

Molecular functions related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1HGF, IL6

Products for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet