MCID: INT145
MIFTS: 25

Intracranial Hemorrhage in Brain Cerebrovascular Malformations malady

Genetic diseases (common), Neuronal diseases categories

Aliases & Classifications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Aliases & Descriptions for Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

Name: Intracranial Hemorrhage in Brain Cerebrovascular Malformations 46
Intracranial Hemorrhage in Brain Cerebrovascular Malformations, Susceptibility to 9
 
Arteriovenous Malformations of the Brain 46


Classifications:



External Ids:

OMIM46 108010

Summaries for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards based summary: Intracranial Hemorrhage in Brain Cerebrovascular Malformations, also known as intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to, is related to inflammatory bowel disease 1 and classic kaposi sarcoma, and has symptoms including autosomal dominant inheritanceand cerebral arteriovenous malformation. An important gene associated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations is HGF (hepatocyte growth factor (hepapoietin A; scatter factor)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds su 11274 and pha 665752 have been mentioned in the context of this disorder. Affiliated tissues include brain.

Description from OMIM:46 108010

Related Diseases for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1inflammatory bowel disease 110.3IL6
2classic kaposi sarcoma10.3IL6
3arteriovenous malformation10.2
4central nervous system vasculitis10.2
5vasculitis10.2
6arteriosclerosis10.2HGF
7diabetes mellitus, insulin-dependent10.1IL6
8endometriosis9.9HGF, IL6
9chronic kidney failure9.9IL6, HGF
10myeloma9.9HGF, IL6
11hepatocellular carcinoma9.9HGF, IL6
12primary hyperoxaluria9.8HGF, IL6

Graphical network of diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:



Diseases related to intracranial hemorrhage in brain cerebrovascular malformations

Symptoms for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Symptoms by clinical synopsis from OMIM:

108010

Clinical features from OMIM:

108010

HPO human phenotypes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 cerebral arteriovenous malformation HP:0002408

Drugs & Therapeutics for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Drug clinical trials:

Search ClinicalTrials for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search NIH Clinical Center for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Genetic Tests for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Anatomical Context for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards organs/tissues related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

31
Brain

Animal Models for Intracranial Hemorrhage in Brain Cerebrovascular Malformations or affiliated genes

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Publications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Variations for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Expression for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Search GEO for disease gene expression data for Intracranial Hemorrhage in Brain Cerebrovascular Malformations.

Pathways for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Pathways related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Compounds related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
1su 11274609.6IL6, HGF
2pha 665752609.6HGF, IL6
3pf 04217903 mesylate609.6IL6, HGF
4rebamipide449.6IL6, HGF
5crizotinib60 5010.5HGF, IL6
6filgrastim44 1110.5IL6, HGF
7pmma449.5HGF, IL6
8dextran sulfate449.5HGF, IL6
9pdtc449.5HGF, IL6
10pge1449.5HGF, IL6
11aprotinin44 1110.5IL6, HGF
12thalidomide44 50 60 1112.5HGF, IL6
13sp 60012544 6010.5HGF, IL6
14prednisolone44 28 1111.5IL6, HGF
15hydrocortisone44 1 60 1112.5IL6, HGF
16tgf beta1449.5HGF, IL6
17herbimycin a44 6010.5IL6, HGF
18hyaluronic acid44 2410.5IL6, HGF
19methotrexate50 44 1111.5HGF, IL6
20n acetylcysteine449.5IL6, HGF
21indomethacin44 28 60 1112.5HGF, IL6
22sb 20358044 6010.5IL6, HGF
23vitamin d449.5HGF, IL6
24norepinephrine44 24 1111.5HGF, IL6
25histamine44 28 2411.4HGF, IL6
26pd 98,059449.4IL6, HGF
27ly294002449.4HGF, IL6
28actinomycin d449.4IL6, HGF
29genistein44 28 60 1 24 1114.4IL6, HGF
30cyclosporin a44 28 6011.4IL6, HGF
31pge2449.4HGF, IL6
32lactate449.4IL6, HGF
33thymidine44 2410.3HGF, IL6
34creatinine449.3HGF, IL6
35cycloheximide449.3IL6, HGF
36testosterone44 60 24 1112.2HGF, IL6
37dexamethasone44 50 28 1112.2HGF, IL6
38vegf449.1IL6, HGF
39retinoic acid44 2410.1IL6, HGF
40alanine449.0IL6, HGF
41estrogen448.8IL6, HGF

GO Terms for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Biological processes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:00456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:00459449.1HGF, IL6
5platelet activationGO:00301689.0IL6, HGF
6negative regulation of apoptotic processGO:00430668.8HGF, IL6

Molecular functions related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.1HGF, IL6

Sources for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet