MCID: INT145
MIFTS: 19

Intracranial Hemorrhage in Brain Cerebrovascular Malformations malady

Genetic diseases (common), Neuronal diseases categories

Aliases & Classifications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Aliases & Descriptions for Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

Name: Intracranial Hemorrhage in Brain Cerebrovascular Malformations 49
 
Intracranial Hemorrhage in Brain Cerebrovascular Malformations, Susceptibility to 11


Classifications:



External Ids:

OMIM49 108010

Summaries for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards based summary: Intracranial Hemorrhage in Brain Cerebrovascular Malformations, also known as intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to, is related to intracranial hemorrhage in brain cerebrovascular malformations and rheumatoid arthritis, systemic juvenile, and has symptoms including abnormality of the cerebral vasculature, visceral angiomatosis and peripheral arteriovenous fistula. An important gene associated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations is IL6 (Interleukin 6), and among its related pathways are Glioma and PI3K-Akt signaling pathway. Affiliated tissues include brain.

Description from OMIM:49 108010

Related Diseases for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1intracranial hemorrhage in brain cerebrovascular malformations9.9HGF, IL6
2rheumatoid arthritis, systemic juvenile9.9HGF, IL6
3blau syndrome9.9HGF, IL6
4breast epithelioid hemangioma9.9HGF, IL6
5lingual goiter9.9HGF, IL6
6ovarian cystic teratoma9.9HGF, IL6
7cervical adenoid basal carcinoma9.9HGF, IL6
8duodenal benign neoplasm9.9HGF, IL6
9adiposis dolorosa9.8HGF, IL6
10artery disease9.8HGF, IL6
11renal cell carcinoma9.8HGF, IL6
12kaposi sarcoma9.8HGF, IL6
13multiple myeloma9.7HGF, IL6

Graphical network of diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:



Diseases related to intracranial hemorrhage in brain cerebrovascular malformations

Symptoms for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Symptoms by clinical synopsis from OMIM:

108010

Clinical features from OMIM:

108010

HPO human phenotypes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

id Description Frequency HPO Source Accession
1 abnormality of the cerebral vasculature hallmark (90%) HP:0100659
2 visceral angiomatosis hallmark (90%) HP:0100761
3 peripheral arteriovenous fistula hallmark (90%) HP:0100784
4 autosomal dominant inheritance HP:0000006
5 cerebral arteriovenous malformation HP:0002408

Drugs & Therapeutics for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Drugs for Intracranial Hemorrhage in Brain Cerebrovascular Malformations (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Epoetin alfaapprovedPhase 2612113427-24-0
Synonyms:
Epogen
 
Erythropoietin precursor
Procrit
2Arginine Vasopressin163
3Thrombin257
4Ferrosoferric Oxide57

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1A Randomized Trial of Unruptured Brain AVMsCompletedNCT00389181Phase 3
2Erythropoietin Therapy for Subarachnoid HemorrhageCompletedNCT00140010Phase 2
3Safety and Tolerability of Factor Xa Variant in Intracerebral HemorrhageNot yet recruitingNCT02687191Phase 1
4Study of Abnormal Blood Clotting in Children With StrokeCompletedNCT00001927
5Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain InjuryCompletedNCT01313975
6Protocol for Staged Stereotactic Radiosurgery for Large Arteriovenous MalformationsCompletedNCT02576535
7Cerebral Hemorrhage Risk in Hereditary Hemorrhagic TelangiectasiaRecruitingNCT01158807
8Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNSRecruitingNCT02452216
9MRI for the Early Evaluation of Acute Intracerebral HemorrhageRecruitingNCT01689402
10Blood-brain Barrier Quantification in Cerebral Small Vessel DiseaseRecruitingNCT02033291
11Effect of Ischemic Strokes on Recovery From Intracerebral HemorrhagesRecruitingNCT01417117
12Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid HemorrhageRecruitingNCT02659878
13Prediction of Major Bleeding in ELBW-infants (<1000g) by Sequential Coagulation MonitoringRecruitingNCT01976013
14Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and OutcomeRecruitingNCT01934725
15Micro Ribonucleic Acid (miRNA) Markers of Hydrocephalus in Intraventricular Hemorrhage (IVH)RecruitingNCT02386228
16Serial Echocardiography After Subarachnoid HemorrhageActive, not recruitingNCT00123695
17Detection and Quantification of Neonatal Intraventricular HemorrhageEnrolling by invitationNCT01899651
18Cerebral Dysfunction in Chronic ITPwith High Risk of Serious Bleeding Excluding Intracranial Hemorrhage.Not yet recruitingNCT01764971
19Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid HaemorrhageNot yet recruitingNCT02482883
20Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral AneurysmTerminatedNCT01801488
21Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid HemorrhageWithdrawnNCT01232400

Search NIH Clinical Center for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Genetic Tests for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Anatomical Context for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards organs/tissues related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

33
Brain

Animal Models for Intracranial Hemorrhage in Brain Cerebrovascular Malformations or affiliated genes

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Publications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Variations for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Expression for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Search GEO for disease gene expression data for Intracranial Hemorrhage in Brain Cerebrovascular Malformations.

Pathways for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Pathways related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1HGF, IL6
29.1HGF, IL6
39.1HGF, IL6
49.1HGF, IL6
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1HGF, IL6
9
Show member pathways
9.1HGF, IL6
10
Show member pathways
9.1HGF, IL6
119.1HGF, IL6
129.1HGF, IL6
139.1HGF, IL6
149.1HGF, IL6
159.1HGF, IL6
169.1HGF, IL6
179.1HGF, IL6
189.1HGF, IL6

GO Terms for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Biological processes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:00456699.5HGF, IL6
2positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4HGF, IL6
3negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.4HGF, IL6
4negative regulation of apoptotic processGO:00430669.4HGF, IL6
5positive regulation of cell proliferationGO:00082849.3HGF, IL6
6platelet activationGO:00301689.1HGF, IL6

Molecular functions related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.1HGF, IL6

Sources for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet