MCID: INT145
MIFTS: 25

Intracranial Hemorrhage in Brain Cerebrovascular Malformations malady

Genetic diseases (common), Neuronal diseases categories

Aliases & Classifications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Intracranial Hemorrhage in Brain Cerebrovascular Malformations, Aliases & Descriptions:

Name: Intracranial Hemorrhage in Brain Cerebrovascular Malformations 45
Intracranial Hemorrhage in Brain Cerebrovascular Malformations, Susceptibility to 10
 
Arteriovenous Malformations of the Brain 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


External Ids:

OMIM45 108010

Summaries for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards based summary: Intracranial Hemorrhage in Brain Cerebrovascular Malformations, also known as intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to, is related to inflammatory bowel disease 1 and classic kaposi sarcoma, and has symptoms including autosomal dominant inheritanceand cerebral arteriovenous malformation. An important gene associated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations is HGF (hepatocyte growth factor (hepapoietin A; scatter factor)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds pha 665752 and pf 04217903 mesylate have been mentioned in the context of this disorder. Affiliated tissues include brain.

Description from OMIM:45 108010

Related Diseases for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1inflammatory bowel disease 110.3IL6
2classic kaposi sarcoma10.3IL6
3arteriovenous malformation10.2
4central nervous system vasculitis10.2
5vasculitis10.2
6arteriosclerosis10.2HGF
7diabetes mellitus, insulin-dependent10.1IL6
8endometriosis9.9HGF, IL6
9chronic kidney failure9.9IL6, HGF
10myeloma9.9HGF, IL6
11hepatocellular carcinoma9.9HGF, IL6
12primary hyperoxaluria9.8HGF, IL6

Graphical network of diseases related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:



Diseases related to intracranial hemorrhage in brain cerebrovascular malformations

Symptoms for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Symptoms by clinical synopsis from OMIM:

108010

Clinical features from OMIM:

108010

HPO human phenotypes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 cerebral arteriovenous malformation HP:0002408

Drugs & Therapeutics for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Drug clinical trials:

Search ClinicalTrials for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Search NIH Clinical Center for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

Genetic Tests for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Anatomical Context for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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MalaCards organs/tissues related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations:

31
Brain

Animal Models for Intracranial Hemorrhage in Brain Cerebrovascular Malformations or affiliated genes

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Publications for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Variations for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Expression for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Search GEO for disease gene expression data for Intracranial Hemorrhage in Brain Cerebrovascular Malformations.

Pathways for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Pathways related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Compounds related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
1pha 665752599.6HGF, IL6
2pf 04217903 mesylate599.6IL6, HGF
3su 11274599.6IL6, HGF
4rebamipide439.6HGF, IL6
5filgrastim43 1210.5IL6, HGF
6crizotinib59 4910.5IL6, HGF
7pmma439.5HGF, IL6
8dextran sulfate439.5IL6, HGF
9pdtc439.5HGF, IL6
10pge1439.5HGF, IL6
11aprotinin43 1210.5IL6, HGF
12thalidomide43 49 59 1212.5HGF, IL6
13sp 60012543 5910.5HGF, IL6
14prednisolone43 28 1211.5IL6, HGF
15hydrocortisone43 2 59 1212.5HGF, IL6
16tgf beta1439.5IL6, HGF
17herbimycin a43 5910.5HGF, IL6
18hyaluronic acid43 2410.5HGF, IL6
19methotrexate49 43 1211.5IL6, HGF
20n acetylcysteine439.5HGF, IL6
21indomethacin43 28 59 1212.5IL6, HGF
22sb 20358043 5910.5HGF, IL6
23vitamin d439.5HGF, IL6
24norepinephrine43 24 1211.5IL6, HGF
25histamine43 28 2411.4HGF, IL6
26pd 98,059439.4IL6, HGF
27ly294002439.4HGF, IL6
28actinomycin d439.4HGF, IL6
29genistein43 28 59 2 24 1214.4IL6, HGF
30cyclosporin a43 28 5911.4HGF, IL6
31pge2439.4IL6, HGF
32lactate439.4HGF, IL6
33thymidine43 2410.3HGF, IL6
34creatinine439.3IL6, HGF
35cycloheximide439.3HGF, IL6
36testosterone43 59 24 1212.2IL6, HGF
37dexamethasone43 49 28 1212.2HGF, IL6
38vegf439.1HGF, IL6
39retinoic acid43 2410.1HGF, IL6
40alanine439.0IL6, HGF
41estrogen438.8HGF, IL6

GO Terms for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Biological processes related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:00456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:00459449.1HGF, IL6
5platelet activationGO:00301689.0IL6, HGF
6negative regulation of apoptotic processGO:00430668.8HGF, IL6

Molecular functions related to Intracranial Hemorrhage in Brain Cerebrovascular Malformations according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.1HGF, IL6

Products for genes affiliated with Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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Sources for Intracranial Hemorrhage in Brain Cerebrovascular Malformations

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet